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Aliases for ASCL4 Gene

Aliases for ASCL4 Gene

  • Achaete-Scute Family BHLH Transcription Factor 4 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 44 3 4
  • Achaete-Scute-Like Protein 4 3 4
  • BHLHa44 3 4
  • ASH-4 3 4
  • HASH4 3 4
  • Achaete-Scute Complex Homolog 4 (Drosophila) 2
  • Achaete-Scute Complex-Like 4 (Drosophila) 2
  • Achaete-Scute Complex Homolog 4 3
  • Achaete-Scute Complex-Like 4 3
  • Class II BHLH Protein ASCL4 3

External Ids for ASCL4 Gene

Previous GeneCards Identifiers for ASCL4 Gene

  • GC12P108101
  • GC12P106670
  • GC12P108168
  • GC12P105228

Summaries for ASCL4 Gene

Entrez Gene Summary for ASCL4 Gene

  • Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ASCL4 Gene

ASCL4 (Achaete-Scute Family BHLH Transcription Factor 4) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is ASCL3.

UniProtKB/Swiss-Prot for ASCL4 Gene

  • Could be a transcriptional regulator involved in skin development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASCL4 Gene

Genomics for ASCL4 Gene

Regulatory Elements for ASCL4 Gene

Genomic Location for ASCL4 Gene

Chromosome:
12
Start:
107,774,385 bp from pter
End:
107,776,644 bp from pter
Size:
2,260 bases
Orientation:
Plus strand

Genomic View for ASCL4 Gene

Genes around ASCL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASCL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASCL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASCL4 Gene

Proteins for ASCL4 Gene

  • Protein details for ASCL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XD76-ASCL4_HUMAN
    Recommended name:
    Achaete-scute homolog 4
    Protein Accession:
    Q6XD76
    Secondary Accessions:
    • Q7RTS2

    Protein attributes for ASCL4 Gene

    Size:
    172 amino acids
    Molecular mass:
    19253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA01055.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ASCL4 Gene

Proteomics data for ASCL4 Gene at MOPED

Post-translational modifications for ASCL4 Gene

No Post-translational modifications

Other Protein References for ASCL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASCL4 Gene

Domains & Families for ASCL4 Gene

Gene Families for ASCL4 Gene

Protein Domains for ASCL4 Gene

Suggested Antigen Peptide Sequences for ASCL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6XD76

UniProtKB/Swiss-Prot:

ASCL4_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ASCL4: view

Function for ASCL4 Gene

Molecular function for ASCL4 Gene

UniProtKB/Swiss-Prot Function:
Could be a transcriptional regulator involved in skin development.

Gene Ontology (GO) - Molecular Function for ASCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ASCL4: view
genes like me logo Genes that share phenotypes with ASCL4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASCL4 Gene

Localization for ASCL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASCL4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASCL4 Gene COMPARTMENTS Subcellular localization image for ASCL4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ASCL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090575 RNA polymerase II transcription factor complex IBA --
genes like me logo Genes that share ontologies with ASCL4: view

Pathways & Interactions for ASCL4 Gene

SuperPathways for ASCL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ASCL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ASCL4 Gene

Drugs & Compounds for ASCL4 Gene

No Compound Related Data Available

Transcripts for ASCL4 Gene

mRNA/cDNA for ASCL4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASCL4 Gene

Achaete-scute complex homolog 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASCL4 Gene

No ASD Table

Relevant External Links for ASCL4 Gene

GeneLoc Exon Structure for
ASCL4
ECgene alternative splicing isoforms for
ASCL4

Expression for ASCL4 Gene

mRNA expression in normal human tissues for ASCL4 Gene

mRNA differential expression in normal tissues according to GTEx for ASCL4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x8.1).

Protein differential expression in normal tissues from HIPED for ASCL4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ASCL4 Gene



SOURCE GeneReport for Unigene cluster for ASCL4 Gene Hs.149910

mRNA Expression by UniProt/SwissProt for ASCL4 Gene

Q6XD76-ASCL4_HUMAN
Tissue specificity: Expressed in skin. 7-fold higher expression in fetal skin than in adult skin. Weak expression also detected in fetal lung, aorta and brain, and in adult stomach, kidney, ovary and breast.
genes like me logo Genes that share expression patterns with ASCL4: view

Protein tissue co-expression partners for ASCL4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ASCL4 Gene

Orthologs for ASCL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASCL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASCL4 35
  • 81.64 (n)
  • 71.86 (a)
ASCL4 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASCL4 35
  • 79.65 (n)
  • 69.77 (a)
ASCL4 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ascl4 35
  • 80.1 (n)
  • 73.64 (a)
Ascl4 16
Ascl4 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASCL4 35
  • 98.51 (n)
  • 96.82 (a)
ASCL4 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ascl4 35
  • 78.04 (n)
  • 68.22 (a)
oppossum
(Monodelphis domestica)
Mammalia ASCL4 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASCL4 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASCL4 35
  • 69.31 (n)
  • 65.87 (a)
ASCL4 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASCL4 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ASCL4 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hlh-6 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for ASCL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASCL4 Gene

ENSEMBL:
Gene Tree for ASCL4 (if available)
TreeFam:
Gene Tree for ASCL4 (if available)

Paralogs for ASCL4 Gene

Paralogs for ASCL4 Gene

(3) SIMAP similar genes for ASCL4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASCL4: view

Variants for ASCL4 Gene

Sequence variations from dbSNP and Humsavar for ASCL4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1974710 -- 107,772,554(+) TGATT(A/C)TCCTG upstream-variant-2KB
rs3070885 -- 107,772,464(+) ttttt(-/T/TTTTTT)gagac upstream-variant-2KB
rs11113472 -- 107,774,808(+) CCTAG(A/G)GTGGT utr-variant-5-prime
rs11614917 -- 107,776,225(+) CATTC(C/T)TTCCT utr-variant-3-prime
rs34132780 -- 107,776,395(+) TTCAT(-/C)CCAGT utr-variant-3-prime

Variation tolerance for ASCL4 Gene

Gene Damage Index Score: 2.99; 49.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASCL4 Gene

HapMap Linkage Disequilibrium report
ASCL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASCL4 Gene

Disorders for ASCL4 Gene

Relevant External Links for ASCL4

Genetic Association Database (GAD)
ASCL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASCL4

No disorders were found for ASCL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASCL4 Gene

Publications for ASCL4 Gene

  1. Hash4, a novel human achaete-scute homologue found in fetal skin. (PMID: 15475265) Jonsson M. … Asp J. (Genomics 2004) 3 4 23 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Role of intramitochondrial arachidonic acid and acyl-CoA synthetase 4 in angiotensin II-regulated aldosterone synthesis in NCI-H295R adrenocortical cell line. (PMID: 22549224) Mele P.G. … PodestA! E.J. (Endocrinology 2012) 3

Products for ASCL4 Gene

Sources for ASCL4 Gene

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