ASCL4 Gene
protein-coding GIFtS: 43
GCID: GC12P108168
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achaete-scute complex homolog 4 (Drosophila)(Previous name: achaete-scute complex-like 4 (Drosophila) )
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Aliases
for ASCL4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Achaete-Scute Complex Homolog 4 (Drosophila)1 2 | | Achaete-Scute Complex-Like 4 (Drosophila)1 | | HASH41 2 3 | | Achaete-Scute Complex-Like 42 | | BHLHa441 | | Achaete-Scute Homolog 42 | | Achaete-Scute-Like Protein 42 3 | | Class II BHLH Protein ASCL42 | | Class A Basic Helix-Loop-Helix Protein 442 3 | | BHLHA443 | | ASH-42 3 | | HASH41 2 3 |
Export aliases for ASCL4 gene to outside databasesPrevious GC identifers: GC12P108101 GC12P106670 GC12P105228 |
Summaries
for ASCL4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ASCL4:
Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and thedevelopment and differentiation of numerous tissues (Jonsson et al., 2004 (PubMed 15475265)).(supplied by OMIM, Mar2008)
UniProtKB/Swiss-Prot: ASCL4_HUMAN, Q6XD76Function: Could be a transcriptional regulator involved in skin development
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Genomic Views
for ASCL4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASCL4 gene promoter:
MEF-2A STAT1 FAC1 FOXC1 AML1a STAT1beta STAT1alpha C/EBPalpha Roaz
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASCL4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCL4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q24.11ASCL4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P108168: view genomic region
(about GC identifiers)
Start:
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108,168,162 bp from pter |
End:
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108,170,421 bp from pter |
Size:
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2,260 bases |
Orientation:
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plus strand |
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Proteins
for ASCL4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASCL4_HUMAN, Q6XD76 (See
protein sequence)Recommended Name: Achaete-scute homolog 4 Size: 172 amino acids; 19253 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=DAA01055.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q7RTS2Explore the universe of human proteins at neXtProt for ASCL4: NX_Q6XD76
ASCL4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_982260.2
ENSEMBL proteins: ENSP00000345420
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ASCL4 for ontologies About GeneDecksing
ASCL4 Antibody Products:
Assay Products for ASCL4: |
Protein
Domains /
Families
for ASCL4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASCL4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6XD76ProtoNet protein and cluster: Q6XD76 1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH
UniProtKB/Swiss-Prot: ASCL4_HUMAN, Q6XD76Similarity: Contains 1 bHLH (basic helix-loop-helix) domain |
Function
for ASCL4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ASCL4_HUMAN, Q6XD76Function: Could be a transcriptional regulator involved in skin development
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ASCL4 (NM_203436) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASCL4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCL4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046983 | protein dimerization activity |
IEA | -- |
ASCL4 for ontologies About GeneDecksing
|
Pathways & Interactions
for ASCL4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASCL4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ASCL4 (Q6XD763 ENSP000003454204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
ASCL4 for ontologies About GeneDecksing
|
Drugs & Compounds
for ASCL4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ASCL4
Search CenterWatch for drugs/clinical trials and news about ASCL4
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Transcripts
for ASCL4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASCL4 gene: NM_203436.2 Unigene Cluster for ASCL4: Achaete-scute complex homolog 4 (Drosophila) Hs.149910 [show with all ESTs]Unigene Representative Sequence: NM_2034361 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000342331(uc001tmr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ASCL4 (NM_203436) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASCL4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCL4 |
Additional cDNA sequence: AY238895.1 BC128211.1 BC128212.1 1 DOTS entry: DT.70101691 6 AceView cDNA sequences: AI290227 NM_203436 BK000275 AY238895 BX092631 AI190511
GeneLoc Exon Structure
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Expression
for ASCL4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASCL4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGTTGTT
About this image
See ASCL4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.149910
UniProtKB/Swiss-Prot: ASCL4_HUMAN, Q6XD76Tissue specificity: Expressed in skin. 7-fold higher expression in fetal skin than in adult skin. Weak expression alsodetected in fetal lung, aorta and brain, and in adult stomach, kidney, ovary and breast
SABiosciences Custom PCR Arrays for ASCL4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASCL4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASCL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASCL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASCL4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL4 |
Orthologs
for ASCL4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for ASCL4 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for ASCL4 (if available)
TreeFam Gene Tree for ASCL4 (if available) |
Paralogs
for ASCL4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ASCL4 gene
- ASCL32 ASCL22 ASCL12
3 SIMAP similar genes for ASCL4 using alignment to 1 protein entry: ASCL4_HUMAN:TAL2 ASCL2 ASCL3
ASCL4 for paralogs About GeneDecksing
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Genomic Variants
for ASCL4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASCL4 (108168162 - 108170421 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ASCL4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASCL4 |
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Disorders
/ Diseases
for ASCL4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASCL4 for disorders About GeneDecksing
OMIM gene information: 609155
OMIM disorders: --
1  disease for ASCL4: About MalaCardskeratosis
Export disorders for ASCL4 gene to outside databases
|
Publications
for ASCL4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASCL4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASCL4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Hash4, a novel human achaete-scute homologue found in fetal skin. (PubMed id 15475265)1, 2, 9 Jonsson M.... Asp J. (2004)
- Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 14516699)1, 2 McLellan A.S.... Kealey T. (2002)
- Role of intramitochondrial arachidonic acid and acyl-C oA synthetase 4 in angiotensin II-regulated aldosterone synthesis in NCI-H295R a drenocortical cell line. (PubMed id 22549224)1 Mele P.G....Podesta E.J. (2012)
- The XLMR gene ACSL4 plays a role in dendritic spine a rchitecture. (PubMed id 19166906)1 Meloni I....Renieri A. (2009)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. (PubMed id 12617822)1 McLellan A.S.... Kealey T. (2002)
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External Searches for ASCL4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ASCL4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ASCL4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASCL4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASCL4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ASCL4 gene:
Search GeneIP for patents involving ASCL4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASCL4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ASCL4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASCL4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASCL4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ASCL4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ASCL4 | | OriGene Custom Protein Services for ASCL4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASCL4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASCL4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCL4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASCL4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASCL4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASCL4 |
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| | | | Search Tocris compounds for ASCL4 |
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 | | | ASCL4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL4 |
|  |  |  | | | | Search ThermoFisher Antibodies for ASCL4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCL4 |
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