ASCL3 Gene
protein-coding GIFtS: 46
GCID: GC11M008959
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|
achaete-scute complex homolog 3 (Drosophila)(Previous name: achaete-scute complex (Drosophila) homolog-like 3 )
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Aliases
for ASCL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Achaete-Scute Complex Homolog 3 (Drosophila)1 2 | | Sgn11 | | HASH31 2 3 | | Achaete-Scute Complex (Drosophila) Homolog-Like 31 | | BHLHa421 | | Achaete-Scute Homolog 32 | | Class A Basic Helix-Loop-Helix Protein 422 3 | | BHLH Transcription Factor Sgn-1 (Salivary Glands 1)2 | | ASH-32 3 | | BHLHA423 | | SGN12 3 | | HASH31 2 3 | | BHLH Transcriptional Regulator Sgn-12 3 | | |
Export aliases for ASCL3 gene to outside databasesPrevious GC identifers: GC11P009957 GC11M009650 GC11M008998 GC11M008923 GC11M008915 GC11M008629 |
Summaries
for ASCL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ASCL3:
Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and thedevelopment and differentiation of numerous tissues (Jonsson et al., 2004 (PubMed 15475265)).(supplied by OMIM, Mar2008)
UniProtKB/Swiss-Prot: ASCL3_HUMAN, Q9NQ33Function: Transcriptional repressor. Inhibits myogenesis (By similarity)
|
Genomic Views
for ASCL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASCL3 gene promoter:
RORalpha1 Nkx3-1 Nkx3-1 v2 Nkx3-1 v4 AML1a COMP1 Nkx3-1 v3 Nkx3-1 v1 HNF-3beta C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASCL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.3 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.3ASCL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M008959: view genomic region
(about GC identifiers)
Start:
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8,959,119 bp from pter |
End:
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8,964,580 bp from pter |
Size:
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5,462 bases |
Orientation:
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minus strand |
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Proteins
for ASCL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASCL3_HUMAN, Q9NQ33 (See
protein sequence)Recommended Name: Achaete-scute homolog 3 Size: 180 amino acids; 20797 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=CAB92288.1; Type=Erroneous initiation;
Secondary accessions: Q8WYQ6Explore the universe of human proteins at neXtProt for ASCL3: NX_Q9NQ33
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NQ33
ASCL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065697.1
ENSEMBL proteins: ENSP00000435770 ENSP00000318846
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ASCL3 for ontologies About GeneDecksing
ASCL3 Antibody Products:
Assay Products for ASCL3: |
Protein
Domains /
Families
for ASCL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASCL3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NQ33ProtoNet protein and cluster: Q9NQ33 1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH
UniProtKB/Swiss-Prot: ASCL3_HUMAN, Q9NQ33Similarity: Contains 1 bHLH (basic helix-loop-helix) domain |
Function
for ASCL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ASCL3_HUMAN, Q9NQ33Function: Transcriptional repressor. Inhibits myogenesis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ASCL3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ASCL3:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ascl3):
ASCL3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ASCL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASCL3
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for ASCL3 (Q9NQ333 ENSP000003188464) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
ISS | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
ISS | -- |
ASCL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ASCL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ASCL3
Search CenterWatch for drugs/clinical trials and news about ASCL3
|
Transcripts
for ASCL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASCL3 gene: NM_020646.1 Unigene Cluster for ASCL3: Achaete-scute complex homolog 3 (Drosophila) Hs.501852 [show with all ESTs]Unigene Representative Sequence: BG1921832 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531618(uc021qdj.1) ENST00000325884(uc001mhd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ASCL3 (NM_020646) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASCL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCL3 |
1 DOTS entry: DT.92060098 3 AceView cDNA sequences: NM_020646 BG199363 BG192183
GeneLoc Exon Structure
|
Expression
for ASCL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASCL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ASCL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASCL3
SOURCE GeneReport for Unigene cluster: Hs.501852
UniProtKB/Swiss-Prot: ASCL3_HUMAN, Q9NQ33Tissue specificity: Widely expressed in fetal and adult tissues
SABiosciences Custom PCR Arrays for ASCL3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASCL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASCL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASCL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASCL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL3 |
Orthologs
for ASCL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ASCL3 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ASCL31 |
achaete-scute complex homolog 3 (Drosophila) |
66.89(n)
62.25(a) |
|
423052 XM_001232098.1 XP_001232099.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ASCL36 |
-- |
51(a) |
1 ↔ 1 |
1(64515564-64517977) |
zebrafish
(Danio rerio) |
Actinopterygii |
CABZ01023701.16 |
-- |
33(a) |
1 → many |
4(60362516-60363604) |
worm
(Caenorhabditis elegans) |
Secernentea |
hlh-66 |
Helix-loop-helix protein 6 |
19(a) |
1 → many |
II(9613404-9614753) |
ENSEMBL Gene Tree for ASCL3 (if available)
TreeFam Gene Tree for ASCL3 (if available) |
Paralogs
for ASCL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ASCL3 gene
- ASCL22 ASCL12 ASCL42
3 SIMAP similar genes for ASCL3 using alignment to 1 protein entry: ASCL3_HUMAN:TAL2 ASCL4 ASCL5
ASCL3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ASCL3
PGOHUM00000244388
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Genomic Variants
for ASCL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASCL3 (8959119 - 8964580 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ASCL3
1 CNV: 3837
1 Indel: 48914 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ASCL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASCL3 for disorders About GeneDecksing
OMIM gene information: 609154
OMIM disorders: --
2  diseases for ASCL3: About MalaCardsplacental choriocarcinoma choriocarcinoma
Export disorders for ASCL3 gene to outside databases
|
Publications
for ASCL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASCL3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASCL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PubMed id 11528127)1, 2, 3 Amid C.... Schmidt E.R. (2001)
- Hash4, a novel human achaete-scute homologue found in fetal skin. (PubMed id 15475265)1, 2, 9 Jonsson M.... Asp J. (2004)
- Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice. (PubMed id 11784080)1, 2 Yoshida S....Nabeshima Y. (2001)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for ASCL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ASCL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASCL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASCL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASCL3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ASCL3 gene:
Search GeneIP for patents involving ASCL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASCL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ASCL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASCL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASCL3 | | | OriGene Protein Over-expression Lysate for ASCL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ASCL3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASCL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ASCL3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASCL3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASCL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASCL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASCL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASCL3 |
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 | | | ASCL3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL3 |
|  |  |  | | | | Search ThermoFisher Antibodies for ASCL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCL3 |
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