Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASCL3 Gene

protein-coding   GIFtS: 46
GCID: GC11M008959

Achaete-Scute Complex Homolog 3 (Drosophila)

(Previous name: achaete-scute complex (Drosophila) homolog-like 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Achaete-Scute Complex Homolog 3 (Drosophila)1 2     BHLH Transcriptional Regulator Sgn-12 3
Class A Basic Helix-Loop-Helix Protein 422 3     Achaete-Scute Complex (Drosophila) Homolog-Like 31
ASH-32 3     Achaete-Scute Homolog 32
HASH32 3     BHLH Transcription Factor Sgn-1 (Salivary Glands 1)2
SGN12 3     BHLHA423
bHLHa422 3     hASH33

External Ids:    HGNC: 7401   Entrez Gene: 566762   Ensembl: ENSG000001760097   OMIM: 6091545   UniProtKB: Q9NQ333   

Export aliases for ASCL3 gene to outside databases

Previous GC identifers: GC11P009957 GC11M009650 GC11M008998 GC11M008923 GC11M008915 GC11M008629


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASCL3 Gene:
Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and
the development and differentiation of numerous tissues (Jonsson et al., 2004 (PubMed 15475265)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for ASCL3 Gene: 
ASCL3 (achaete-scute complex homolog 3 (Drosophila)) is a protein-coding gene. Diseases associated with ASCL3 include placental choriocarcinoma, and choriocarcinoma. GO annotations related to this gene include protein dimerization activity and DNA binding. An important paralog of this gene is ASCL1.

UniProtKB/Swiss-Prot: ASCL3_HUMAN, Q9NQ33
Function: Transcriptional repressor. Inhibits myogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASCL3 gene promoter:
         RORalpha1   Nkx3-1   Nkx3-1 v2   Nkx3-1 v4   AML1a   COMP1   Nkx3-1 v3   Nkx3-1 v1   HNF-3beta   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASCL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASCL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.3

ASCL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASCL3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M008959:  view genomic region     (about GC identifiers)

Start:
8,959,119 bp from pter      End:
8,964,580 bp from pter
Size:
5,462 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASCL3_HUMAN, Q9NQ33 (See protein sequence)
Recommended Name: Achaete-scute homolog 3  
Size: 180 amino acids; 20797 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=CAB92288.1; Type=Erroneous initiation;
Secondary accessions: Q8WYQ6

Explore the universe of human proteins at neXtProt for ASCL3: NX_Q9NQ33

Explore proteomics data for ASCL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQ33

  • ASCL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ASCL3 Protein Expression
    REFSEQ proteins: NP_065697.1  
    ENSEMBL proteins: 
     ENSP00000435770   ENSP00000318846  

    Human Recombinant Protein Products for ASCL3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ASCL3
    OriGene Protein Over-expression Lysate for ASCL3
    OriGene MassSpec for ASCL3 
    OriGene Custom Protein Services for ASCL3
    GenScript Custom Purified and Recombinant Proteins Services for ASCL3
    Novus Biologicals ASCL3 Proteins
    Novus Biologicals ASCL3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ASCL3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    ASCL3 for ontologies           About GeneDecksing



    ASCL3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ASCL3
    GenScript Custom Superior Antibodies Services for ASCL3
    Novus Biologicals ASCL3 Antibodies
    Abcam antibodies for ASCL3
    Cloud-Clone Corp. Antibodies for ASCL3 
    Search ThermoFisher Antibodies for ASCL3
    LSBio Antibodies in human, mouse, rat for ASCL3 

    Assay Products for ASCL3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ASCL3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ASCL3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ASCL3 
    Cloud-Clone Corp. CLIAs for ASCL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR015660 ASH
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q9NQ33

    ProtoNet protein and cluster: Q9NQ33

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: ASCL3_HUMAN, Q9NQ33
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    ASCL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASCL3_HUMAN, Q9NQ33
    Function: Transcriptional repressor. Inhibits myogenesis (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    ASCL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASCL3:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ascl3):
     normal 

    ASCL3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ASCL3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ASCL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASCL3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASCL3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASCL3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ASCL3:
    hsa-miR-4261
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ASCL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASCL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ASCL3
    Sirion Biotech Customized adenovirus for overexpression of ASCL3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ASCL3 (see all 6)
    OriGene ORF clones in mouse, rat for ASCL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ASCL3 (NM_020646)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCL3
    Sirion Biotech Customized lentivirus for stable overexpression of ASCL3 
                         Customized lentivirus expression plasmids for stable overexpression of ASCL3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ASCL3
    Search LifeMap BioReagents cell lines for ASCL3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASCL3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ASCL3 (Q9NQ333 ENSP000003188464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    MYOD1P151723, ENSP000002500034I2D: score=1 STRING: ENSP00000250003
    TCF3P159233, ENSP000002629654I2D: score=3 STRING: ENSP00000262965
    TCF4P158843, ENSP000003464404I2D: score=1 STRING: ENSP00000346440
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent ISS--
    GO:0006357regulation of transcription from RNA polymerase II promoter ISS--

    ASCL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASCL3

    Search CenterWatch for drugs/clinical trials and news about ASCL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASCL3 gene: 
    NM_020646.1  

    Unigene Cluster for ASCL3:

    Achaete-scute complex homolog 3 (Drosophila)
    Hs.501852  [show with all ESTs]
    Unigene Representative Sequence: BG192183
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531618(uc021qdj.1) ENST00000325884(uc001mhd.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASCL3
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ASCL3:
    hsa-miR-4261
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ASCL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASCL3
    Clone
    Products:
         
    OriGene clones in human, mouse for ASCL3 (see all 6)
    OriGene ORF clones in mouse, rat for ASCL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ASCL3 (NM_020646)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASCL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCL3
    Sirion Biotech Customized lentivirus for stable overexpression of ASCL3 
                         Customized lentivirus expression plasmids for stable overexpression of ASCL3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ASCL3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASCL3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASCL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASCL3

    1 DOTS entry:

    DT.92060098 

    3 AceView cDNA sequences:

    NM_020646 BG199363 BG192183 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASCL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ASCL3 Expression
    About this image


    See ASCL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASCL3

    SOURCE GeneReport for Unigene cluster: Hs.501852

    UniProtKB/Swiss-Prot: ASCL3_HUMAN, Q9NQ33
    Tissue specificity: Widely expressed in fetal and adult tissues

        SABiosciences Custom PCR Arrays for ASCL3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ASCL3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASCL3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASCL3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASCL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ASCL3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ascl31 , 5 achaete-scute complex homolog 3 (Drosophila)1, 5 74.52(n)1
    68.39(a)1
      7 (57.46 cM)5
    567871  NM_020051.11  NP_064435.11 
     1097274655 
    chicken
    (Gallus gallus)
    Aves ASCL31 achaete-scute complex homolog 3 (Drosophila) 66.89(n)
    62.25(a)
      423052  XM_001232098.1  XP_001232099.2 
    lizard
    (Anolis carolinensis)
    Reptilia ASCL36
    ASCL46
    Uncharacterized protein
    52(a)
    36(a)
    1 ↔ 1
    possible ortholog
    1(64515564-64517977)
    5(19864809-19865482)
    zebrafish
    (Danio rerio)
    Actinopterygii ASCL36
    achaete-scute complex homolog 3 (Drosophila)
    29(a)
    1 ↔ 1
    4(60362516-60363604)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-66
    Helix-loop-helix protein 6
    18(a)
    1 ↔ 1
    II(9613463-9614812)


    ENSEMBL Gene Tree for ASCL3 (if available)
    TreeFam Gene Tree for ASCL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASCL3 gene
    ASCL12  ASCL22  ASCL52  ASCL42  
    3 SIMAP similar genes for ASCL3 using alignment to 1 protein entry:     ASCL3_HUMAN:
    TAL2    ASCL4    ASCL5

    ASCL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ASCL3
    PGOHUM00000244388


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 SNPs in ASCL3 are shown (see all 226)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs750389171,2
    F--8958678(+) AAGGTT/ATTGTA 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs93000961,2
    C,F,A,H--8958694(+) CTTTCG/ACTTTA 1 -- ds500131Minor allele frequency- A:0.44NS EA NA WA CSA 2782
    rs1407803751,2
    C--8958719(+) TCCCAG/TGGTGG 1 -- ds50010--------
    rs594896081,2
    C,F--8958827(+) ACGACC/TGGCAT 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs37510641,2
    C,F,H--8958903(-) CTCACA/GTGCTC 1 -- ds500112Minor allele frequency- G:0.28NS EA NA WA CSA 785
    rs1459106461,2
    --8958986(+) CTCCTA/CAACCT 1 -- ds50010--------
    rs37510631,2
    C,F,A,H--8959020(-) TTGGGT/CTTCAA 1 -- ds500129Minor allele frequency- C:0.44NS EA NA WA CSA 2776
    rs1384904901,2
    C,F--8959152(+) ATTTGG/AAAACA 1 -- ut311Minor allele frequency- A:0.00EU 1321
    rs2021069341,2
    C--8959255(+) TTTATC/GAGGGT 2 H D mis10--------
    rs2010146471,2
    --8959295(+) TTGATC/GGCAGC 2 A syn10--------

    HapMap Linkage Disequilibrium report for ASCL3 (8959119 - 8964580 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ASCL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv435923CNV Deletion17901297
    dgv191e199CNV Deletion23128226
    nsv832062CNV Loss17160897
    nsv520248CNV Loss19592680
    essv24306CNV CNV17122850
    nsv499766OTHER Inversion21111241
    nsv7215OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ASCL3
    DNA2.0 Custom Variant and Variant Library Synthesis for ASCL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609154    OMIM disorders: --

    2 diseases for ASCL3:    About MalaCards
    placental choriocarcinoma    choriocarcinoma


    ASCL3 for disorders           About GeneDecksing


    Export disorders for ASCL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASCL3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ASCL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PubMed id 11528127)1, 2, 3 Amid C.... Schmidt E.R. (2001)
    2. Hash4, a novel human achaete-scute homologue found in fetal skin. (PubMed id 15475265)1, 2, 9 Jonsson M.... Asp J. (2004)
    3. Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice. (PubMed id 11784080)1, 2 Yoshida S....Nabeshima Y. (2001)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56676 HGNC: 740 AceView: ASCL3 Ensembl:ENSG00000176009 euGenes: HUgn56676
    ECgene: ASCL3 H-InvDB: ASCL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASCL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ASCL3 gene:
    Search GeneIP for patents involving ASCL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ASCL3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ASCL3  
     OriGene MassSpec something-or-other for ASCL3   OriGene clones in human, mouse for ASCL3  
     OriGene qSTAR qPCR primer pairs in human, mouse for ASCL3   OriGene Purified Protein for ASCL3  
     OriGene ORF clones in mouse, rat for ASCL3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ASCL3   OriGene Custom Protein Services for ASCL3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASCL3
     QIAGEN SeqTarget long-range PCR primers for resequencing ASCL3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCL3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASCL3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASCL3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASCL3
     GenScript Custom Purified and Recombinant Proteins Services for ASCL3 GenScript cDNA clones with any tag delivered in your preferred vector for ASCL3
     GenScript Custom Assay Services for ASCL3 GenScript Custom Superior Antibodies Services for ASCL3
     GenScript Custom overexpressing Cell Line Services for ASCL3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ASCL3 promoter
     Search Chromatin IP Primers for ASCL3
     RT2 qPCR Primer Assay in human, mouse, rat ASCL3
     Search GNC Networks for ASCL3
     SABiosciences Custom PCR Arrays for ASCL3
     Search Tocris compounds for ASCL3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ASCL3 antibodies
     ASCL3 proteins
     ASCL3 lysates
     Antibodies for ASCL3
     See all of Abcam's Antibodies, Kits and Proteins for ASCL3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ASCL3
     Antibodies for ASCL3
     ELISAs for ASCL3
     CLIAs for ASCL3
     Search LifeMap BioReagents cell lines for ASCL3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ASCL3
     SwitchGear Promoter luciferase reporter plasmids for ASCL3
     Search ThermoFisher Antibodies for ASCL3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCL3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ASCL3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ASCL3
    Customized:
     lentivirus for stable overexpression of ASCL3
     lentivirus expression plasmids for stable overexpression of ASCL3
     adenovirus for overexpression of ASCL3
     LSBio Antibodies in human, mouse, rat for ASCL3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ASCL3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4