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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASCL2 Gene

protein-coding   GIFtS: 56
GCID: GC11M002289

Achaete-Scute Complex Homolog 2 (Drosophila)

(Previous names: achaete-scute complex (Drosophila) homolog-like 2, achaete-scute...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Achaete-Scute Complex Homolog 2 (Drosophila)1 2     MASH22
Class A Basic Helix-Loop-Helix Protein 452 3     Achaete-Scute Complex-Like 22
ASH-22 3     Achaete-Scute Homolog 22
HASH22 3     Mammalian Achaete/Scute Homologue 22
bHLHa452 3     BHLHA453
Achaete-Scute Complex (Drosophila) Homolog-Like 21     Mash23
Achaete-Scute Complex-Like 2 (Drosophila)1     hASH23
ASH22     

External Ids:    HGNC: 7391   Entrez Gene: 4302   Ensembl: ENSG000001837347   OMIM: 6018865   UniProtKB: Q999293   

Export aliases for ASCL2 gene to outside databases

Previous GC identifers: GC11P002271 GC11M002491 GC11M002249 GC11M002254 GC11M002246 GC11M002079


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASCL2 Gene:
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates
transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for
efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system
and the central nervous system. (provided by RefSeq, Jul 2008)

GeneCards Summary for ASCL2 Gene: 
ASCL2 (achaete-scute complex homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with ASCL2 include choriocarcinoma, and beckwith-wiedemann syndrome. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ASCL3.

UniProtKB/Swiss-Prot: ASCL2_HUMAN, Q99929
Function: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous
system and the central nervous system

Gene Wiki entry for ASCL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASCL2 gene promoter:
         AhR   USF1   RREB-1   p300   Bach2   USF2   USF-1:USF-2   Arnt   CREB   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASCL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASCL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

ASCL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASCL2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M002289:  view genomic region     (about GC identifiers)

Start:
2,289,725 bp from pter      End:
2,292,182 bp from pter
Size:
2,458 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASCL2_HUMAN, Q99929 (See protein sequence)
Recommended Name: Achaete-scute homolog 2  
Size: 193 amino acids; 20185 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Interacts with SETD1A.Part of a
complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, KIAA1967, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and
ZNF335; this complex may have a histone H3-specific methyltransferase activity
Subcellular location: Nucleus
Secondary accessions: Q6PEY9 Q9UM68

Explore the universe of human proteins at neXtProt for ASCL2: NX_Q99929

Explore proteomics data for ASCL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99929

  • ASCL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ASCL2 Protein Expression
    REFSEQ proteins: NP_005161.1  
    ENSEMBL proteins: 
     ENSP00000332293  

    Human Recombinant Protein Products for ASCL2: 
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    Cloud-Clone Corp. Proteins for ASCL2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8751384
    GO:0005737cytoplasm IDA12917334

    ASCL2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ASCL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR015660 ASH
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q99929

    ProtoNet protein and cluster: Q99929

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: ASCL2_HUMAN, Q99929
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    ASCL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASCL2_HUMAN, Q99929
    Function: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous
    system and the central nervous system

         Genatlas biochemistry entry for ASCL2:
    Drosophila achaete-scute homolog 2,expressed in extravillus trophoblast,paternally imprinted,telomeric imprinting
    domain at 11p15,containing ASCL2,IGF2,H19

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS8751384
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046983protein dimerization activity IEA--
    GO:0070888E-box binding IDA14561729
         
    ASCL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASCL2:
     Decreased viability of wild-ty 

         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ascl2):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     homeostasis/metabolism  mortality/aging  no phenotypic analysis  normal 

    ASCL2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ASCL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ASCL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASCL2 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ASCL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Human Early Embryo Development
    Human Early Embryo Development

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ASCL2
        Human Early Embryo Development


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ASCL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/16 Interacting proteins for ASCL2 (Q999293 ENSP000003322934) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074373, ENSP000004100714I2D: score=1 STRING: ENSP00000410071
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    ENSG00000229684P074373I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA14561729
    GO:0001666response to hypoxia IEP14561729
    GO:0001701in utero embryonic development ----
    GO:0001890placenta development NAS14561729
    GO:0006351transcription, DNA-dependent IDA14561729

    ASCL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASCL2

    Search CenterWatch for drugs/clinical trials and news about ASCL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASCL2 gene: 
    NM_005170.2  

    Unigene Cluster for ASCL2:

    Achaete-scute complex homolog 2 (Drosophila)
    Hs.152475  [show with all ESTs]
    Unigene Representative Sequence: NM_005170
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331289(uc001lvu.3)
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCL2
    Sirion Biotech Customized lentivirus for stable overexpression of ASCL2 
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    OriGene qPCR primer pairs and template standards for ASCL2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASCL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASCL2

    Additional mRNA sequence: 

    BC028140.1 BC057801.1 BC136561.1 BC136567.1 

    3 DOTS entries:

    DT.433595  DT.100692217  DT.97777710 

    24/41 AceView cDNA sequences (see all 41):

    AI393930 BX114633 BC028140 BC057801 AI337239 CA432756 AI337448 CR603858 
    NM_005170 AW083899 BX434280 AA565767 AA468668 BX339751 C00634 BX366756 
    BX387740 BX339752 BX458875 AA565752 AI861937 BM856944 BI908780 BM311314 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASCL2 expression in normal human tissues (normalized intensities)      ASCL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCAAGA
    ASCL2 Expression
    About this image


    ASCL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 3 entries
             Extraembryonic Ectoderm Cells Extraembryonic Ectoderm
             Trophoblast
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/midbrain   
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
             Primitive Cytotrophoblast Cells Chorion Frondosum
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See ASCL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASCL2

    SOURCE GeneReport for Unigene cluster: Hs.152475

    UniProtKB/Swiss-Prot: ASCL2_HUMAN, Q99929
    Tissue specificity: Expressed specifically in the extravillous trophoblasts of the developing placenta

        SABiosciences Expression via Pathway-Focused PCR Array including ASCL2: 
              Stem Cells in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ASCL2 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ascl21 , 5 achaete-scute complex homolog 2 (Drosophila)1, 5 77.72(n)1
    74.09(a)1
      7 (88.08 cM)5
    171731  NM_008554.31  NP_032580.21 
     1429668295 
    chicken
    (Gallus gallus)
    Aves ASCL21 achaete-scute complex homolog 2 (Drosophila) 67.27(n)
    68.07(a)
      395791  XM_003641355.1  XP_003641403.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ascl1b6
    achaete-scute complex-like 1b (Drosophila)
    45(a)
    1 ↔ 1
    7(51172738-51174183)
    fruit fly
    (Drosophila melanogaster)
    Insecta ac6
    l(1)sc6
    (see all 4)
    lethal of scute
    (see all 4)
    22(a)
    19(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    X(264064-264980)
    X(303756-304850)
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-36
    hlh-146
    Protein HLH-14
    24(a)
    13(a)
    many ↔ many
    many ↔ many
    II(9086608-9087917)
    II(5737790-5739792)


    ENSEMBL Gene Tree for ASCL2 (if available)
    TreeFam Gene Tree for ASCL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASCL2 gene
    ASCL32  ASCL12  ASCL52  ASCL42  
    3 SIMAP similar genes for ASCL2 using alignment to 1 protein entry:     ASCL2_HUMAN:
    ASCL1    ASCL4    TAL2

    ASCL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/66 SNPs in ASCL2 are shown (see all 66)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813307601,2
    C--2289354(+) GCCACA/GTTAGT 1 -- int10--------
    rs1383014311,2
    --2289371(+) CTGAGC/TGTGGT 1 -- int10--------
    rs1127204601,2
    C,F--2289398(+) CATGCC/ACTCAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs2003926271,2
    C--2289408(+) GCCCCA/CCNNNN 1 -- int10--------
    rs122837891,2
    C,F--2289424(+) TCTCTG/AGTCAG 1 -- int16Minor allele frequency- A:0.28NA CSA WA EA 363
    rs342454241,2
    C,F--2289483(+) GGTCC-/CA    
       C
    /CCA
    AGCAG
    2 -- cds15EU EA NA MN 430
    rs1140370201,2
    F--2289503(+) TGCAGC/TTTCCA 1 -- int11Minor allele frequency- T:0.01WA 118
    rs790303621,2
    F--2289521(+) GAGTAG/TCCCTG 1 -- int12Minor allele frequency- T:0.19CSA WA 120
    rs1867124441,2
    --2289645(+) CCCTAC/TGGAGG 1 -- int10--------
    rs1460577421,2
    C--2289646(+) CCTACA/GGAGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ASCL2 (2289725 - 2292182 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ASCL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv896776CNV Loss21882294
    nsv896801CNV Loss21882294
    nsv467645CNV Gain19166990
    nsv825708CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601886    OMIM disorders: --

    6 diseases for ASCL2:    About MalaCards
    choriocarcinoma    beckwith-wiedemann syndrome    hypoxia    colorectal cancer
    neuronitis    colon cancer

    1 disease from the University of Copenhagen DISEASES database for ASCL2:
    Beckwith-Wiedemann syndrome

    ASCL2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ASCL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 50.7 1 11043580 (1)
    cancer 0 2 17165436 (1)

    Genetic Association Database (GAD): ASCL2

    Export disorders for ASCL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASCL2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with ASCL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts. (PubMed id 9175731)1, 2, 3, 9 Alders M.... Mannens M. (1997)
    2. The human Achaete Scute homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization. (PubMed id 11440538)1, 2, 9 Westerman B.A....Oudejans C.B. (2001)
    3. Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2). (PubMed id 8751384)1, 2, 9 Miyamoto T....Ishikawa M. (1996)
    4. Detection of HASH2 (ASCL2) gene expression in gestational trophoblastic disease. (PubMed id 17165436)1, 9 Shahib M.N....Kato H. (2006)
    5. USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia. (PubMed id 12917334)1, 9 Jiang B. and Mendelson C.R. (2003)
    6. A SacII polymorphism in the human ASCL2 (HASH2) gene region. (PubMed id 9610003)1, 9 Miyamoto T....Ishikawa M. (1998)
    7. Aberrant upregulation of ASCL2 by promoter demethylati on promotes the growth and resistance to 5-fluorouracil of gastric cancer cells. (PubMed id 23181270)1 Kwon O.H....Kim Y.S. (2013)
    8. Microcephaly gene links trithorax and REST/NRSF to con trol neural stem cell proliferation and differentiation. (PubMed id 23178126)2 Yang Y.J....Walsh C.A. (2012)
    9. Ascl2 knockdown results in tumor growth arrest by miRN A-302b-related inhibition of colon cancer progenitor cells. (PubMed id 22384170)1 Zhu R....Wang R. (2012)
    10. Human AP endonuclease (APE1/Ref-1) and its acetylatio n regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-indu ced activation of multidrug resistance gene MDR1. (PubMed id 20856196)1 Sengupta S....Bhakat K.K. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 430 HGNC: 739 AceView: ASCL2 Ensembl:ENSG00000183734 euGenes: HUgn430
    ECgene: ASCL2 H-InvDB: ASCL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASCL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ASCL2 gene:
    Search GeneIP for patents involving ASCL2

    GeneCards and IP:
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