Aliases for ASCL2 Gene
External Ids for ASCL2 Gene
Previous GeneCards Identifiers for ASCL2 Gene
This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]
GeneCards Summary for ASCL2 Gene
ASCL2 (Achaete-Scute Family BHLH Transcription Factor 2) is a Protein Coding gene. Diseases associated with ASCL2 include beckwith-wiedemann syndrome. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Human Early Embryo Development. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ASCL4.
UniProtKB/Swiss-Prot for ASCL2 Gene
AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.