V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ASCL1 Gene

protein-coding GIFtS: 63

GC12P101856

achaete-scute complex homolog 1 (Drosophila)
(Previous names: achaete-scute complex (Drosophila) homolog-like 1, achaete-scute complex-like 1 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ASH1 ^¹, ², ³, ⁵
HASH1 ^¹, ², ³
MASH1 ^²
bHLHa46 ^¹, ²

Descriptions
achaete scute protein ^²
achaete-scute complex (Drosophila) homolog-like 1 ^¹
achaete-scute complex homolog 1 ^²
achaete-scute complex homolog 1 (Drosophila) ^²
achaete-scute complex-like 1 ^²
achaete-scute complex-like 1 (Drosophila) ^¹

External Ids
HGNC: 738¹
Entrez Gene: 429²
UniProtKB: P50553³
Ensembl: ENSG00000139352⁷

Search outside databases for aliases for ASCL1 gene

Previous GC identifers: GC12P102450 GC12P103310 GC12P101854 GC12P101855

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ASCL1:

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors.

The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization

with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the

neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons.

Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS)

phenotype in rare cases. [provided by RefSeq]

UniProtKB/Swiss-Prot: ASCL1_HUMAN, P50553

Function: May play a role at early stages of development of specific neural lineages in most

regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory

and autonomic neurons. Activates transcription by binding to the E box (5'-CANNTG-3')

Gene Wiki entry for ASCL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ASCL1 gene

Entrez Gene cytogenetic band: 12q23.2 Ensembl cytogenetic band: 12q23.2 HGNC cytogenetic band: 12q22-q23

ASCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P101856: (about GC identifiers)

Start:	101,875,594 bp from pter
End:	101,878,421 bp from pter
Size:	2,828 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_019546.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ASCL1_HUMAN, P50553 (See protein sequence)

Recommended Name: Achaete-scute homolog 1

Size: 236 amino acids; 25454 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer

with TCF3

Subcellular location: Nucleus (Probable)

Secondary accessions: Q9BQ30

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004307.2

ENSEMBL proteins:

ENSP00000266744

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MASH1/Achaete-scute homolog 1)
	Human Recombinant Proteins from Abnova (ASCL1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0043025	cell soma	IEA	--

About this table

Antibodies for ASCL1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ASCL1
	Sigma-Aldrich Antibodies for ASCL1
	R&D Systems Antibodies for ASCL1 (Mash1)
	Antibodies from Abcam (MASH1/Achaete-scute homolog 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ASCL1)
	Novus Biologicals Antibodies for ASCL1

Assays for ASCL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P50553

ProtoNet protein and cluster: P50553

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: ASCL1_HUMAN, P50553

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ASCL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ASCL1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004316

Applied Biosystems Silencer® siRNAs for ASCL1

Sigma-Aldrich siRNA for ASCL1

Sigma-Aldrich shRNA for ASCL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ASCL1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004316
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004316
untagged cDNA clones in CMV expression vector (see all 2): NM_004316

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004316

UniProtKB/Swiss-Prot: ASCL1_HUMAN, P50553

Function: May play a role at early stages of development of specific neural lineages in most

regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory

and autonomic neurons. Activates transcription by binding to the E box (5'-CANNTG-3')

Genatlas biochemistry entry for ASCL1:

Drosophila achaete-scute homolog 1,downregulated in differentiating neuroblastoma cells

10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ascl1):

behavior/neurological	growth/size	lethality-prenatal/perinatal	nervous system	no phenotypic analysis
pigmentation	respiratory system	skin/coat/nails	taste/olfaction	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	8390674
GO:0005515	protein binding	IPI	10903890
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ASCL1

5/53 Interacting proteins for ASCL1 (ENSP00000266744³ P50553¹) via UniProtKB, MINT, and/or STRING (see all 53 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TCF3	P15923¹	STRING (score=.761) EBI-957042, EBI-769630
TCF4	P15884¹	STRING (score=.972) EBI-957042, EBI-533224
DLX1	ENSP00000354478³	STRING (score=.986)
PHOX2A	ENSP00000298231³	STRING (score=.979)
TLX3	ENSP00000296921³	STRING (score=.968)

About this table

5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007389	pattern specification process	IEA	--
GO:0007399	nervous system development	IEA	--
GO:0007400	neuroblast fate determination	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ASCL1
4 Novoseek chemical compound relationships for ASCL1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lithium chloride	37.40	3	17263970 (1), 17363508 (1)
phenylalanine	1.30	1	8595908 (1)
lysine	0.00	4	10430036 (1), 15031712 (1)
tyrosine	0.00	1	17034791 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ASCL1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ASCL1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004316

Sigma-Aldrich siRNA for ASCL1

Sigma-Aldrich shRNA for ASCL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004316

REFSEQ mRNAs for ASCL1 gene:

NM_004316.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004316

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004316
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004316
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004316

Additional cDNA sequence:

AK290539.1 AK314114.1 BC001638.2 BC002341.2 BC003134.1 BC004425.1 BC031299.1 CR615179.1

L08424.1

4 DOTS entries:

DT.450436 DT.95096800 DT.95360797 DT.95078444

24/140 AceView cDNA sequences (see all 140 ):

AI934490 AW248896 BM696219 AW166088 BM715329 AI369271 CR615179 BE221091

BC002341 AW149352 AI885738 BM677526 AW139639 AI279866 BM021413 BU742375

AI300010 BF433583 BC031299 AW249707 AW246655 AI869311 AW131522 AW131798

highest scoring ESTs for ASCL1:

AI359957 L08424 AA350158 AA350159 AA442045 AA488142 AA826434 AA908710 AA911550 AI279194

Unigene Cluster for ASCL1:

Achaete-scute complex homolog 1 (Drosophila)

Hs.704281 [show with all ESTs]

Unigene Representative Sequence: NM_004316

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000266744

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ASCL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ASCL1

¹ / ² / ³

11 probe-sets matching ASCL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40544_g_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.74	L08424	1.00	1.00	1.00	1
57815_at²^{, 3}	U95-C	1	1.00	1.00	0.94	1.51	AI359957	1.00	1.00	1.00	1
40543_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.87	L08424	1.00	1.00	1.00	1
209988_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001638	0.80	1.00	0.91	1
209985_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE797438	0.60	1.00	0.82	1
213768_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW950513	0.60	1.00	0.82	1
209987_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC002341	0.80	1.00	0.91	1
209988_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209985_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213768_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209987_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ASCL1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.704281
Expression variation in blood from EXPOLDB for ASCL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ASCL1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ASCL1¹	--	achaete-scute complex homolog 1 (Drosophila)	94.32(n) 96.51(a)	482628 XM_539745.2 XP_539745.2
cow (Bos taurus)	ASCL1¹	--	achaete-scute complex homolog 1 (Drosophila)	92.39(n) 94.52(a)	540473 XM_594382.3 XP_594382.3
rat (Rattus norvegicus)	Ascl1¹	--	achaete-scute complex homolog 1 (Drosophila)	90.56(n) 97(a)	64186 NM_022384.1 NP_071779.1
mouse (Mus musculus)	Ascl1^{1, 5}	10⁵	achaete-scute complex homolog 1 (Drosophila)^{1, 5}	90.62(n)¹ 95.67(a)¹	17172¹ NM_008553.4¹ NP_032579.2¹ AI225900⁵ AI415258⁵ (see all 11)
zebrafish (Danio rerio)	asha²	--	achaete scute homolog A	80.99(n)	30466 NM_131219.1

About this table Species with no ortholog for ASCL1

ENSEMBL Gene Tree for ASCL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ASCL1 gene

ASCL3² ASCL2² ASCL4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/43 NCBI SNPs in ASCL1 are shown (see all 43 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 21)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9782^1,2	A,C,F,H	101875956(-)	`AAAAAA/GGTGAA`	1	--	ut5¹		9		MN EU EA WA NA	966
--	rs1874875^1,2	A,C,F	101878678(-)	`GGCATG/CTACAT`	1	--	ng3¹		7		NA EU EA WA	562
--	rs1391682^1,2	C,F	101877655(-)	`GGGCGG/AGGAGG`	1	--	ut3¹ ese³		1		MN	184
	rs11111420^1,2	C,H	101876860(+)	`TGGTTC/GTGAGG`	1	F/L	mis¹ ese³		8		EU EA WA	836
--	rs2291854^1,2	C,F	101877668(-)	`GCACTC/TTAAGA`	1	--	ut3¹		3		NA	142
	rs1803157^1,2	C,H	101876625(+)	`GGTGGA/GGACAC`	1	E/G	mis¹ ese³		4		EU EA WA	418
	rs9506^1,2	A,H	101876044(+)	`CTTTTC/TTTTCC`	1	--	ut5¹ trp³		5		MN EU EA WA	598
--	rs4578454^1,2	C,F	101878903(+)	`CCTCTT/CCACAT`	1	--	ng3¹		7		NA EU EA WA	562
--	rs17450122^1,2	C,F	101878524(+)	`AAAACA/GTGCTA`	1	--	ng3¹		7		NA EU EA WA	562
--	rs1042851^1,2	C	101875826(-)	`TCTAAA/GAAAAA`	1	--	ut5¹ trp³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ASCL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 100790 disorders: 209880 209880

10/17 Novoseek disease relationships for ASCL1 gene (see all 17 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neuroendocrine tumors	72.70	15	14657947 (3), 8751579 (2), 18563491 (1), 17874277 (1) (see all 7)
central hypoventilation syndrome, congenital	66.35	1	14532329 (1)
thyroid carcinoma medullary	64.88	3	8751579 (1), 14668716 (1), 17090547 (1)
small cell lung cancer	63.15	12	18587322 (4), 11948117 (2), 9144241 (1), 11193209 (1) (see all 5)
carcinoid	53.88	21	15701827 (4), 14657947 (2), 15870121 (2), 11193209 (1) (see all 5)
carcinoma neuroendocrine	51.14	9	14657947 (3), 18751955 (1)
lung carcinoma	38.64	6	17507989 (1), 14657947 (1), 15318167 (1)
teratocarcinoma	36.36	2	8662987 (1)
cancer lung	32.79	31	16322211 (5), 9144241 (3), 14657947 (3), 18339843 (3) (see all 11)
pheochromocytoma	27.13	1	9186001 (1)

About this table

Human Gene Mutation Database: ASCL1
Genetic Association Database: ASCL1
Human Genome Epidemiology Navigator: ASCL1 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/137 PubMed articles for ASCL1 gene (see all 137 ):

Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. (PubMed id 8390674)^{1, 2, 3, 4} Ball D.W.... Nelkin B.D. (1993)
Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. (PubMed id 15240857)^{1, 3, 6} Weese-Mayer D.E....Marazita M.L. (2004)
Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease. (PubMed id 16021468)^{3, 6} Ide M....Yoshikawa T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma. (PubMed id 16103883)^{1, 3} Somasundaram K....Rao M.R. (2005)
Notch signaling induces rapid degradation of achaete-scute homolog 1. (PubMed id 11940670)^{1, 3} Sriuranpong V....Ball D.W. (2002)
Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine features. (PubMed id 11948117)^{1, 3} Westerman B.A....Oudejans C.B. (2002)
Translational regulation of the human achaete-scute homologue-1 by fragile X mental retardation protein. (PubMed id 19097999)^{1, 3} FAohling M....Scholz H. (2009)
MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma. (PubMed id 18587322)^{1, 3} Ralston J....Nonaka D. (2008)
Aberrant expression of human achaete-scute homologue gene 1 in the gastrointestinal neuroendocrine carcinomas. (PubMed id 15701827)^{1, 3} Shida T....Ishikura H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 429	HGNC: 738	AceView: ASCL1	Ensembl:ENSG00000139352	euGenes: HUgn429
ECgene: ASCL1	H-InvDB: ASCL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ASCL1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ASCL1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ASCL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ASCL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ASCL1		Antibodies for ASCL1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ASCL1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ASCL1)
	Antibodies (ASCL1)
	Chimera RNAi (ASCL1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (MASH1/Achaete-scute homolog 1)
	Antibodies (MASH1/Achaete-scute homolog 1)

Search OriGene for ASCL1

Search Tocris compounds for ASCL1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ASCL1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ASCL1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

ASCL1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ASCL1

Summaries
for ASCL1

Genomic Location
for ASCL1

Proteins
for ASCL1

Protein Domains/
Families
for ASCL1

Gene Function
for ASCL1

Pathways & Interactions
for ASCL1

Drugs & Compounds
for ASCL1

Transcripts
for ASCL1

Expression
for ASCL1

Orthologs
for ASCL1

Paralogs
for ASCL1

SNPs/Variants
for ASCL1

Disorders & Mutations
for ASCL1

Medical News
for ASCL1

Publications
for ASCL1

Search for ASCL1

Genome Databases showing ASCL1

Other Databases showing ASCL1

Specialized Databases showing ASCL1

Licensable Technologies
for ASCL1

Services
for ASCL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ASCL1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ASCL1

Summariesfor ASCL1

Genomic Locationfor ASCL1

Proteinsfor ASCL1

Protein Domains/Familiesfor ASCL1

Gene Functionfor ASCL1

Pathways & Interactionsfor ASCL1

Drugs & Compoundsfor ASCL1

Transcriptsfor ASCL1

Expression for ASCL1

Orthologsfor ASCL1

Paralogsfor ASCL1

SNPs/Variantsfor ASCL1

Disorders & Mutationsfor ASCL1

Medical Newsfor ASCL1

Publicationsfor ASCL1

Search for ASCL1

Genome Databases showing ASCL1

Other Databases showing ASCL1

Specialized Databases showing ASCL1

Licensable Technologiesfor ASCL1

Servicesfor ASCL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ASCL1

Summaries
for ASCL1

Genomic Location
for ASCL1

Proteins
for ASCL1

Protein Domains/
Families
for ASCL1

Gene Function
for ASCL1

Pathways & Interactions
for ASCL1

Drugs & Compounds
for ASCL1

Transcripts
for ASCL1

Expression
for ASCL1

Orthologs
for ASCL1

Paralogs
for ASCL1

SNPs/Variants
for ASCL1

Disorders & Mutations
for ASCL1

Medical News
for ASCL1

Publications
for ASCL1

Licensable Technologies
for ASCL1

Services
for ASCL1