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Aliases for ASCC3 Gene

Aliases for ASCC3 Gene

  • Activating Signal Cointegrator 1 Complex Subunit 3 2 3
  • Helicase, ATP Binding 1 2 3 4
  • ASC-1 Complex Subunit P200 3 4
  • Trip4 Complex Subunit P200 3 4
  • RNA Helicase Family 2 3
  • ASC1p200 3 4
  • HELIC1 3 4
  • EC 3.6.4.12 4
  • P200 6
  • RNAH 3

External Ids for ASCC3 Gene

Previous HGNC Symbols for ASCC3 Gene

  • HELIC1

Previous GeneCards Identifiers for ASCC3 Gene

  • GC06M101063
  • GC06M100956
  • GC06M098395

Summaries for ASCC3 Gene

Entrez Gene Summary for ASCC3 Gene

  • This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for ASCC3 Gene

ASCC3 (Activating Signal Cointegrator 1 Complex Subunit 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent 3-5 DNA helicase activity. An important paralog of this gene is SNRNP200.

UniProtKB/Swiss-Prot for ASCC3 Gene

  • 3-5 DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.

Gene Wiki entry for ASCC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASCC3 Gene

Genomics for ASCC3 Gene

Regulatory Elements for ASCC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ASCC3 Gene

Start:
100,508,194 bp from pter
End:
100,881,372 bp from pter
Size:
373,179 bases
Orientation:
Minus strand

Genomic View for ASCC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASCC3 Gene

Proteins for ASCC3 Gene

  • Protein details for ASCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3C0-ASCC3_HUMAN
    Recommended name:
    Activating signal cointegrator 1 complex subunit 3
    Protein Accession:
    Q8N3C0
    Secondary Accessions:
    • E7EW23
    • O43738
    • Q4G1A0
    • Q5VTN2
    • Q9H1I9
    • Q9H5A2
    • Q9NTR0

    Protein attributes for ASCC3 Gene

    Size:
    2202 amino acids
    Molecular mass:
    251460 Da
    Quaternary structure:
    • Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKBH3.
    SequenceCaution:
    • Sequence=AAG45474.1; Type=Frameshift; Positions=2175; Evidence={ECO:0000305}; Sequence=CAA11679.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA11679.1; Type=Frameshift; Positions=2175; Evidence={ECO:0000305};

    Alternative splice isoforms for ASCC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASCC3 Gene

Proteomics data for ASCC3 Gene at MOPED

Post-translational modifications for ASCC3 Gene

  • Ubiquitination at Lys236, Lys319, Lys423, Lys860, Lys938, Lys1382, and Lys1543
  • Modification sites at PhosphoSitePlus

Other Protein References for ASCC3 Gene

No data available for DME Specific Peptides for ASCC3 Gene

Domains for ASCC3 Gene

Suggested Antigen Peptide Sequences for ASCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N3C0

UniProtKB/Swiss-Prot:

ASCC3_HUMAN :
  • Q8N3C0
Domain:
  • Contains 2 helicase ATP-binding domains.
  • Contains 2 helicase C-terminal domains.
  • Contains 2 SEC63 domains.
Family:
  • Belongs to the helicase family.
genes like me logo Genes that share domains with ASCC3: view

No data available for Gene Families for ASCC3 Gene

Function for ASCC3 Gene

Molecular function for ASCC3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function: 3-5 DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.

Enzyme Numbers (IUBMB) for ASCC3 Gene

Gene Ontology (GO) - Molecular Function for ASCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 22055184
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with ASCC3: view
genes like me logo Genes that share phenotypes with ASCC3: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ASCC3 Gene

Localization for ASCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASCC3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASCC3 Gene COMPARTMENTS Subcellular localization image for ASCC3 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 3
plasma membrane 3
mitochondrion 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for ASCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus TAS 22055184
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with ASCC3: view

Pathways for ASCC3 Gene

SuperPathways for ASCC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ASCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006307 DNA dealkylation involved in DNA repair TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008283 cell proliferation IMP 22055184
genes like me logo Genes that share ontologies with ASCC3: view

No data available for Pathways by source for ASCC3 Gene

Transcripts for ASCC3 Gene

Unigene Clusters for ASCC3 Gene

Activating signal cointegrator 1 complex subunit 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASCC3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASCC3 Gene

No ASD Table

Relevant External Links for ASCC3 Gene

GeneLoc Exon Structure for
ASCC3
ECgene alternative splicing isoforms for
ASCC3

Expression for ASCC3 Gene

mRNA expression in normal human tissues for ASCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASCC3 Gene

SOURCE GeneReport for Unigene cluster for ASCC3 Gene Hs.486031

mRNA Expression by UniProt/SwissProt for ASCC3 Gene

Q8N3C0-ASCC3_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ASCC3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ASCC3 Gene

Orthologs for ASCC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASCC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASCC3 35
  • 99.73 (n)
  • 99.68 (a)
ASCC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASCC3 35
  • 91.7 (n)
  • 91.82 (a)
ASCC3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASCC3 35
  • 92.29 (n)
  • 92.37 (a)
ASCC3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ascc3 35
  • 88.54 (n)
  • 92.35 (a)
Ascc3 16
Ascc3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASCC3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASCC3 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ascc3 35
  • 88.02 (n)
  • 92.68 (a)
chicken
(Gallus gallus)
Aves ASCC3 35
  • 79.96 (n)
  • 83.46 (a)
ASCC3 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASCC3 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ascc3 35
  • 70.56 (n)
  • 80.76 (a)
ASCC3 36
  • 84 (a)
OneToMany
ASCC3 (2 of 3) 36
  • 43 (a)
OneToMany
ASCC3 (3 of 3) 36
  • 83 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001234 35
  • 53.68 (n)
  • 54.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5205 35
  • 55.54 (n)
  • 55.35 (a)
CG5205 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54E2A.4 35
  • 52.53 (n)
  • 48.56 (a)
Y54E2A.4 36
  • 46 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR142W 35
  • 54.02 (n)
  • 50.99 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BRR2 36
  • 32 (a)
OneToMany
SLH1 35
  • 55.11 (n)
  • 49.34 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09889g 35
  • 54.35 (n)
  • 48.91 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G61140 35
  • 55.83 (n)
  • 54.25 (a)
rice
(Oryza sativa)
Liliopsida Os.26874 35
Os03g0213400 35
  • 55.84 (n)
  • 53.27 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08267 35
  • 52.33 (n)
  • 50.98 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug81 35
  • 55.13 (n)
  • 49.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2602 36
  • 61 (a)
OneToOne
Species with no ortholog for ASCC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ASCC3 Gene

ENSEMBL:
Gene Tree for ASCC3 (if available)
TreeFam:
Gene Tree for ASCC3 (if available)

Paralogs for ASCC3 Gene

Paralogs for ASCC3 Gene

Selected SIMAP similar genes for ASCC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ASCC3: view

Variants for ASCC3 Gene

Sequence variations from dbSNP and Humsavar for ASCC3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs14159 -- 100,540,365(-) AGATT(C/T)GCCAG missense, reference
rs108422 -- 100,591,403(-) TCTTG(C/G)AAAAC intron-variant
rs151572 -- 100,663,108(-) aatga(A/G)gaata intron-variant
rs151573 -- 100,638,457(-) TAcag(A/G)tatac intron-variant
rs151637 -- 100,656,315(-) TTCGT(A/G)TCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASCC3 Gene

Variant ID Type Subtype PubMed ID
nsv886444 CNV Loss 21882294
dgv6953n71 CNV Loss 21882294
dgv6954n71 CNV Loss 21882294
dgv6955n71 CNV Loss 21882294
dgv6956n71 CNV Loss 21882294
nsv470848 CNV Loss 18288195
nsv463989 CNV Loss 19166990
nsv886454 CNV Loss 21882294
esv1269345 CNV Insertion 17803354
nsv463990 CNV Loss 19166990
nsv521897 CNV Loss 19592680
nsv886457 CNV Loss 21882294
esv1007226 CNV Insertion 20482838
esv28841 CNV Gain 19812545
esv259569 OTHER Complex 20981092
esv273447 CNV Insertion 20981092
esv2732486 CNV Deletion 23290073
nsv510044 CNV Loss 20534489

Relevant External Links for ASCC3 Gene

HapMap Linkage Disequilibrium report
ASCC3
Human Gene Mutation Database (HGMD)
ASCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASCC3 Gene

Disorders for ASCC3 Gene

Relevant External Links for ASCC3

Genetic Association Database (GAD)
ASCC3
Human Genome Epidemiology (HuGE) Navigator
ASCC3
genes like me logo Genes that share disorders with ASCC3: view

No data available for UniProtKB/Swiss-Prot for ASCC3 Gene

Publications for ASCC3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. (PMID: 22055184) Dango S. … Shi Y. (Mol. Cell 2011) 3 4

Products for ASCC3 Gene

Sources for ASCC3 Gene

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