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Aliases for ASCC2 Gene

Aliases for ASCC2 Gene

  • Activating Signal Cointegrator 1 Complex Subunit 2 2 3
  • ASC-1 Complex Subunit P100 3 4
  • Trip4 Complex Subunit P100 3 4
  • ASC1p100 3 4
  • P100 3 6
  • ASC 1 Complex Subunit P100 2

External Ids for ASCC2 Gene

Previous GeneCards Identifiers for ASCC2 Gene

  • GC22M028512
  • GC22M030184
  • GC22M013146

Summaries for ASCC2 Gene

GeneCards Summary for ASCC2 Gene

ASCC2 (Activating Signal Cointegrator 1 Complex Subunit 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ASCC2 Gene

  • Enhances NF-kappa-B, SRF and AP1 transactivation

Gene Wiki entry for ASCC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASCC2 Gene

Genomics for ASCC2 Gene

Regulatory Elements for ASCC2 Gene

Genomic Location for ASCC2 Gene

Start:
29,788,608 bp from pter
End:
29,838,304 bp from pter
Size:
49,697 bases
Orientation:
Minus strand

Genomic View for ASCC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASCC2 Gene

Proteins for ASCC2 Gene

  • Protein details for ASCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1I8-ASCC2_HUMAN
    Recommended name:
    Activating signal cointegrator 1 complex subunit 2
    Protein Accession:
    Q9H1I8
    Secondary Accessions:
    • B7Z8E0
    • F5H6J9
    • Q4TT54
    • Q8TAZ0
    • Q9H711
    • Q9H9D6

    Protein attributes for ASCC2 Gene

    Size:
    757 amino acids
    Molecular mass:
    86360 Da
    Quaternary structure:
    • Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKHB3.
    SequenceCaution:
    • Sequence=BAB15089.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ASCC2 Gene

    Alternative splice isoforms for ASCC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASCC2 Gene

Proteomics data for ASCC2 Gene at MOPED

Post-translational modifications for ASCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASCC2 Gene

Domains for ASCC2 Gene

Protein Domains for ASCC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ASCC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1I8

UniProtKB/Swiss-Prot:

ASCC2_HUMAN :
  • Q9H1I8
Domain:
  • Contains 1 CUE domain.
Family:
  • Belongs to the ASCC2 family.
genes like me logo Genes that share domains with ASCC2: view

No data available for Gene Families for ASCC2 Gene

Function for ASCC2 Gene

Molecular function for ASCC2 Gene

UniProtKB/Swiss-Prot Function: Enhances NF-kappa-B, SRF and AP1 transactivation

Gene Ontology (GO) - Molecular Function for ASCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASCC2: view

Phenotypes for ASCC2 Gene

genes like me logo Genes that share phenotypes with ASCC2: view

miRNA for ASCC2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASCC2 Gene

Localization for ASCC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASCC2 Gene COMPARTMENTS Subcellular localization image for ASCC2 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ASCC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASCC2 Gene

Pathways for ASCC2 Gene

SuperPathways for ASCC2 Gene

No Data Available

Interacting Proteins for ASCC2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305502%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000384273%0d%0a9606.ENSP00000360266%0d%0a9606.ENSP00000261884%0d%0a9606.ENSP00000265354%0d%0a
Selected Interacting proteins: Q9H1I8-ASCC2_HUMAN ENSP00000305502 for ASCC2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for ASCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006307 DNA dealkylation involved in DNA repair TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ASCC2: view

No data available for Pathways by source for ASCC2 Gene

Transcripts for ASCC2 Gene

Unigene Clusters for ASCC2 Gene

Activating signal cointegrator 1 complex subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASCC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - -
SP2: -
SP3:
SP4: - - -
SP5: - -
SP6: - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10: - - - -
SP11: - -
SP12: - - - - - - - -
SP13: - - -
SP14: - - - -
SP15: - - - - - -
SP16: - - - - -
SP17: -
SP18: - - - -
SP19:
SP20: - - -
SP21:
SP22: - - -

ExUns: 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:
SP22:

Relevant External Links for ASCC2 Gene

GeneLoc Exon Structure for
ASCC2
ECgene alternative splicing isoforms for
ASCC2

Expression for ASCC2 Gene

mRNA expression in normal human tissues for ASCC2 Gene

mRNA differential expression in normal tissues according to GTEx for ASCC2 Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASCC2 Gene

SOURCE GeneReport for Unigene cluster for ASCC2 Gene Hs.731754

mRNA Expression by UniProt/SwissProt for ASCC2 Gene

Q9H1I8-ASCC2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with ASCC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ASCC2 Gene

Orthologs for ASCC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASCC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASCC2 35
  • 99.56 (n)
  • 99.47 (a)
ASCC2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASCC2 35
  • 87.1 (n)
  • 88.35 (a)
ASCC2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASCC2 35
  • 90.44 (n)
  • 92.16 (a)
ASCC2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ascc2 35
  • 86.99 (n)
  • 87.83 (a)
Ascc2 16
Ascc2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASCC2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASCC2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ascc2 35
  • 87.17 (n)
  • 87.97 (a)
chicken
(Gallus gallus)
Aves ASCC2 35
  • 73.22 (n)
  • 75.3 (a)
ASCC2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASCC2 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia asc1p100-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ascc2 35
  • 63.26 (n)
  • 62.94 (a)
Str.10308 35
zebrafish
(Danio rerio)
Actinopterygii ascc2 35
  • 59.82 (n)
  • 57.85 (a)
ascc2 36
  • 55 (a)
OneToOne
zgc63666 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000428 35
  • 45.03 (n)
  • 28.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2701 35
  • 46.68 (n)
  • 32.02 (a)
CG2701 36
  • 26 (a)
OneToOne
Species with no ortholog for ASCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASCC2 Gene

ENSEMBL:
Gene Tree for ASCC2 (if available)
TreeFam:
Gene Tree for ASCC2 (if available)

Paralogs for ASCC2 Gene

Selected SIMAP similar genes for ASCC2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ASCC2: view

No data available for Paralogs for ASCC2 Gene

Variants for ASCC2 Gene

Sequence variations from dbSNP and Humsavar for ASCC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs7954 -- 29,788,961(+) GGAGC(A/G)CGGCC utr-variant-3-prime
rs12647 -- 29,825,099(-) ACTCA(C/T)AAGGA reference, synonymous-codon
rs28265 - 29,804,772(-) GGGTG(C/G)ACAGA missense, reference
rs36571 - 29,804,724(+) ATTAG(A/G)CTCCT reference, missense
rs36572 -- 29,804,947(+) CTATA(C/T)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASCC2 Gene

Variant ID Type Subtype PubMed ID
nsv3590 CNV Insertion 18451855
esv2724130 CNV Deletion 23290073
esv2740727 CNV Deletion 23290073
esv2067033 CNV Deletion 18987734
esv2724131 CNV Deletion 23290073
esv2724132 CNV Deletion 23290073

Relevant External Links for ASCC2 Gene

HapMap Linkage Disequilibrium report
ASCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASCC2 Gene

Disorders for ASCC2 Gene

No disorders were found for ASCC2 Gene.

No data available for UniProtKB/Swiss-Prot for ASCC2 Gene

Publications for ASCC2 Gene

  1. Novel transcription coactivator complex containing activating signal cointegrator 1. (PMID: 12077347) Jung D.-J. … Lee Y.C. (Mol. Cell. Biol. 2002) 2 3 4
  2. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 2 3
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ASCC2 Gene

Sources for ASCC2 Gene

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