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Aliases for ASCC2 Gene

Aliases for ASCC2 Gene

  • Activating Signal Cointegrator 1 Complex Subunit 2 2 3 5
  • ASC-1 Complex Subunit P100 3 4
  • Trip4 Complex Subunit P100 3 4
  • ASC1p100 3 4
  • ASC 1 Complex Subunit P100 2
  • P100 3

External Ids for ASCC2 Gene

Previous GeneCards Identifiers for ASCC2 Gene

  • GC22M028512
  • GC22M030184
  • GC22M013146

Summaries for ASCC2 Gene

GeneCards Summary for ASCC2 Gene

ASCC2 (Activating Signal Cointegrator 1 Complex Subunit 2) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and DNA Damage Reversal.

UniProtKB/Swiss-Prot for ASCC2 Gene

  • Enhances NF-kappa-B, SRF and AP1 transactivation.

Gene Wiki entry for ASCC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASCC2 Gene

Genomics for ASCC2 Gene

Regulatory Elements for ASCC2 Gene

Promoters for ASCC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ASCC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASCC2 Gene

Chromosome:
22
Start:
29,788,608 bp from pter
End:
29,838,304 bp from pter
Size:
49,697 bases
Orientation:
Minus strand

Genomic View for ASCC2 Gene

Genes around ASCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASCC2 Gene

Proteins for ASCC2 Gene

  • Protein details for ASCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1I8-ASCC2_HUMAN
    Recommended name:
    Activating signal cointegrator 1 complex subunit 2
    Protein Accession:
    Q9H1I8
    Secondary Accessions:
    • B7Z8E0
    • F5H6J9
    • Q4TT54
    • Q8TAZ0
    • Q9H711
    • Q9H9D6

    Protein attributes for ASCC2 Gene

    Size:
    757 amino acids
    Molecular mass:
    86360 Da
    Quaternary structure:
    • Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKHB3.
    SequenceCaution:
    • Sequence=BAB15089.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ASCC2 Gene

    Alternative splice isoforms for ASCC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASCC2 Gene

Proteomics data for ASCC2 Gene at MOPED

Post-translational modifications for ASCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ASCC2 Gene

Domains & Families for ASCC2 Gene

Protein Domains for ASCC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ASCC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1I8

UniProtKB/Swiss-Prot:

ASCC2_HUMAN :
  • Contains 1 CUE domain.
  • Belongs to the ASCC2 family.
Domain:
  • Contains 1 CUE domain.
Family:
  • Belongs to the ASCC2 family.
genes like me logo Genes that share domains with ASCC2: view

No data available for Gene Families for ASCC2 Gene

Function for ASCC2 Gene

Molecular function for ASCC2 Gene

UniProtKB/Swiss-Prot Function:
Enhances NF-kappa-B, SRF and AP1 transactivation.
genes like me logo Genes that share phenotypes with ASCC2: view

Animal Models for ASCC2 Gene

MGI Knock Outs for ASCC2:

Animal Model Products

miRNA for ASCC2 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASCC2 Gene

Localization for ASCC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASCC2 Gene COMPARTMENTS Subcellular localization image for ASCC2 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASCC2 Gene

Pathways & Interactions for ASCC2 Gene

genes like me logo Genes that share pathways with ASCC2: view

Interacting Proteins for ASCC2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305502%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000265354%0d%0a9606.ENSP00000360266%0d%0a9606.ENSP00000384273%0d%0a9606.ENSP00000261884%0d%0a
Selected Interacting proteins: Q9H1I8-ASCC2_HUMAN ENSP00000305502 for ASCC2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for ASCC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006307 DNA dealkylation involved in DNA repair TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ASCC2: view

No data available for SIGNOR curated interactions for ASCC2 Gene

Drugs & Compounds for ASCC2 Gene

No Compound Related Data Available

Transcripts for ASCC2 Gene

Unigene Clusters for ASCC2 Gene

Activating signal cointegrator 1 complex subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASCC2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^
SP1: - - - -
SP2: -
SP3:
SP4: - - -
SP5: - -
SP6: - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10: - - - -
SP11: - -
SP12: - - - - - - - -
SP13: - - -
SP14: - - - -
SP15: - - - - - -
SP16: - - - - -
SP17: -
SP18: - - - -
SP19:
SP20: - - -
SP21:
SP22: - - -

ExUns: 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20:
SP21:
SP22:

Relevant External Links for ASCC2 Gene

GeneLoc Exon Structure for
ASCC2
ECgene alternative splicing isoforms for
ASCC2

Expression for ASCC2 Gene

mRNA expression in normal human tissues for ASCC2 Gene

mRNA differential expression in normal tissues according to GTEx for ASCC2 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for ASCC2 Gene

This gene is overexpressed in Lung (15.8), Pancreas (10.3), and Heart (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ASCC2 Gene



SOURCE GeneReport for Unigene cluster for ASCC2 Gene Hs.731754

mRNA Expression by UniProt/SwissProt for ASCC2 Gene

Q9H1I8-ASCC2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with ASCC2: view

Protein tissue co-expression partners for ASCC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ASCC2 Gene

Orthologs for ASCC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASCC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASCC2 36
  • 99 (a)
OneToOne
ASCC2 35
  • 99.56 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia ASCC2 35
  • 87.1 (n)
  • 88.35 (a)
ASCC2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASCC2 36
  • 92 (a)
OneToOne
ASCC2 35
  • 90.44 (n)
  • 92.16 (a)
mouse
(Mus musculus)
Mammalia Ascc2 36
  • 87 (a)
OneToOne
Ascc2 16
Ascc2 35
  • 86.99 (n)
  • 87.83 (a)
oppossum
(Monodelphis domestica)
Mammalia ASCC2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASCC2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ascc2 35
  • 87.17 (n)
  • 87.97 (a)
chicken
(Gallus gallus)
Aves ASCC2 35
  • 73.22 (n)
  • 75.3 (a)
ASCC2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASCC2 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia asc1p100-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ascc2 35
  • 63.26 (n)
  • 62.94 (a)
Str.10308 35
zebrafish
(Danio rerio)
Actinopterygii ascc2 35
  • 59.82 (n)
  • 57.85 (a)
zgc63666 35
ascc2 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000428 35
  • 45.03 (n)
  • 28.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2701 35
  • 46.68 (n)
  • 32.02 (a)
CG2701 36
  • 26 (a)
OneToOne
Species with no ortholog for ASCC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASCC2 Gene

ENSEMBL:
Gene Tree for ASCC2 (if available)
TreeFam:
Gene Tree for ASCC2 (if available)

Paralogs for ASCC2 Gene

(1) SIMAP similar genes for ASCC2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ASCC2: view

No data available for Paralogs for ASCC2 Gene

Variants for ASCC2 Gene

Sequence variations from dbSNP and Humsavar for ASCC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs4823054 - 29,802,036(+) CCAGC(C/T)GCTCC reference, missense
rs28265 - 29,804,772(-) GGGTG(C/G)ACAGA reference, missense
rs36571 - 29,804,724(+) ATTAG(A/C/G)CTCCT reference, missense
rs6006259 - 29,793,363(+) ACCTG(A/C/T)GGCTG reference, missense
rs1894473 - 29,825,212(+) ATAGC(A/G)CAGGT reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ASCC2 Gene

Variant ID Type Subtype PubMed ID
nsv3590 CNV Insertion 18451855
esv2724130 CNV Deletion 23290073
esv2740727 CNV Deletion 23290073
esv2067033 CNV Deletion 18987734
esv2724131 CNV Deletion 23290073
esv2724132 CNV Deletion 23290073

Variation tolerance for ASCC2 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.14; 92.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASCC2 Gene

HapMap Linkage Disequilibrium report
ASCC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASCC2 Gene

Disorders for ASCC2 Gene

Relevant External Links for ASCC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASCC2

No disorders were found for ASCC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASCC2 Gene

Publications for ASCC2 Gene

  1. Novel transcription coactivator complex containing activating signal cointegrator 1. (PMID: 12077347) Jung D.-J. … Lee Y.C. (Mol. Cell. Biol. 2002) 2 3 4 67
  2. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ASCC2 Gene

Sources for ASCC2 Gene

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