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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASCC1 Gene

protein-coding   GIFtS: 53
GCID: GC10M073856

Activating Signal Cointegrator 1 Complex Subunit 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Activating Signal Cointegrator 1 Complex Subunit 11 2
ASC-1 Complex Subunit P502 3
Trip4 Complex Subunit P502 3
ASC1p502
p502

External Ids:    HGNC: 242681   Entrez Gene: 510082   Ensembl: ENSG000001383037   OMIM: 6142155   UniProtKB: Q8N9N23   

Export aliases for ASCC1 gene to outside databases

Previous GC identifers: GC10M073201 GC10M073526 GC10M067850


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASCC1 Gene:
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a
transcriptional coactivator that plays an important role in gene transactivation by multiple transcription
factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF).
The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation
by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma.
Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. (provided by
RefSeq, Dec 2011)

GeneCards Summary for ASCC1 Gene: 
ASCC1 (activating signal cointegrator 1 complex subunit 1) is a protein-coding gene. Diseases associated with ASCC1 include barrett's esophagus, and esophageal adenocarcinoma. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2
Function: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine
signals, it is involved in the induction of SERPINB2 expression by gastrin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASCC1 gene promoter:
         TBP   AhR   NRSF form 1   NRSF form 2   Arnt   AREB6   SRY   TFIID   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASCC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASCC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASCC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10pter-q25.3   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

ASCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASCC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M073856:  view genomic region     (about GC identifiers)

Start:
73,856,274 bp from pter      End:
73,976,892 bp from pter
Size:
120,619 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2 (See protein sequence)
Recommended Name: Activating signal cointegrator 1 complex subunit 1  
Size: 400 amino acids; 45509 Da
Subunit: Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKHB3
Subcellular location: Cytoplasm
Sequence caution: Sequence=CAI15908.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5SW06 Q5SW07 Q96EI8 Q9Y307
Alternative splicing: 2 isoforms:  Q8N9N2-1   Q8N9N2-2   

Explore the universe of human proteins at neXtProt for ASCC1: NX_Q8N9N2

Explore proteomics data for ASCC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N9N2

  • ASCC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ASCC1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001185727.1  NP_001185728.1  NP_001185729.1  

    ENSEMBL proteins: 
     ENSP00000339404   ENSP00000320810   ENSP00000431299   ENSP00000436409   ENSP00000320461  
     ENSP00000435147   ENSP00000436098   ENSP00000435191   ENSP00000431255   ENSP00000432418  
     ENSP00000431573   ENSP00000434468   ENSP00000431419   ENSP00000431746   ENSP00000442121  
     ENSP00000378377   ENSP00000378373  

    Human Recombinant Protein Products for ASCC1: 
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    Novus Biologicals ASCC1 Lysates
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ASCC1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex IDA12077347
    GO:0005737cytoplasm IEA--

    ASCC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR019510 Kinase-A_anchor_nucl_local_sig
     IPR004087 KH_dom
     IPR004088 KH_dom_type_1
     IPR009210 Euk_LigT
     IPR009097 RNA_ligase/cNuc_Pdiesterase

    Graphical View of Domain Structure for InterPro Entry Q8N9N2

    ProtoNet protein and cluster: Q8N9N2

    2 Blocks protein domains:
    IPB004087 KH domain
    IPB004088 KH


    UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2
    Similarity: Contains 1 KH domain


    ASCC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASCC1_HUMAN, Q8N9N2
    Function: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine
    signals, it is involved in the induction of SERPINB2 expression by gastrin

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003824catalytic activity IEA--
         
    ASCC1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ASCC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ASCC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASCC1 
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ASCC1:
    hsa-miR-520f hsa-miR-3065-3p hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidASCC1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASCC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for ASCC1 (Q8N9N23 ENSP000003204614) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASCC3Q8N3C03, ENSP000003202524I2D: score=1 STRING: ENSP00000320252
    JUNP054123, ENSP000003602664I2D: score=1 STRING: ENSP00000360266
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    SRFP118313, ENSP000002653544I2D: score=1 STRING: ENSP00000265354
    NCOA6Q146863, ENSP000003518944I2D: score=1 STRING: ENSP00000351894
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA12077347
    GO:0016070RNA metabolic process ----

    ASCC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASCC1

    Search CenterWatch for drugs/clinical trials and news about ASCC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASCC1 gene (4 alternative transcripts): 
    NM_001198798.2  NM_001198799.2  NM_001198800.2  NM_015947.3  

    Unigene Cluster for ASCC1:

    Activating signal cointegrator 1 complex subunit 1
    Hs.500007  [show with all ESTs]
    Unigene Representative Sequence: NM_001198799
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000342444(uc001jsr.2 uc001jst.2) ENST00000317168(uc001jsu.2)
    ENST00000534259 ENST00000486689 ENST00000530394 ENST00000317126 ENST00000525286
    ENST00000526801 ENST00000531048 ENST00000461369 ENST00000530461 ENST00000527593
    ENST00000524829 ENST00000532011 ENST00000526751 ENST00000492502 ENST00000533958
    ENST00000545550

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ASCC1:
    hsa-miR-520f hsa-miR-3065-3p hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidASCC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of ASCC1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASCC1

    Additional mRNA sequence: 

    AF132952.1 AK023436.1 AK093971.1 AK094170.1 AK096409.1 AK124364.1 AK298302.1 AL359339.1 
    AY013290.1 BC012291.1 NR_045564.1 

    24/25 DOTS entries (see all 25):

    DT.95137233  DT.100798146  DT.121298981  DT.100675854  DT.100798141  DT.449768  DT.91882785  DT.100798143 
    DT.92449647  DT.100649903  DT.100798147  DT.92327556  DT.100024808  DT.86839587  DT.100038625  DT.100798140 
    DT.121299053  DT.100038624  DT.121298986  DT.121299003  DT.95137235  DT.100822174  DT.75170944  DT.92449652 

    24/190 AceView cDNA sequences (see all 190):

    CB153828 BF034437 BF589908 AI356915 BI771496 BP873463 AI638750 AI824867 
    AK124364 BX455134 AA383429 CD172350 BU181425 F10524 BG575282 CR619307 
    AA282796 F02489 BI918953 AA394161 AI638179 AL524871 BU623884 AA177055 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ASCC1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                        -                                       
    SP2:                          -                             -                 -     -               
    SP3:                                                        -                 -                     
    SP4:                                                                          -     -               


    ECgene alternative splicing isoforms for ASCC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASCC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGTACCAC
    ASCC1 Expression
    About this image


    See ASCC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASCC1

    SOURCE GeneReport for Unigene cluster: Hs.500007

    UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for ASCC1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASCC1 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ascc11 , 5 activating signal cointegrator 1 complex subunit 11, 5 83.61(n)1
    86.8(a)1
      10 (29.67 cM)5
    690901  NM_001199187.21  NP_001186116.11 
     600028055 
    chicken
    (Gallus gallus)
    Aves ASCC11 activating signal cointegrator 1 complex subunit 1 68.47(n)
    66.67(a)
      423709  XM_421588.3  XP_421588.3 
    lizard
    (Anolis carolinensis)
    Reptilia ASCC16
    activating signal cointegrator 1 complex subunit 1...
    58(a)
    1 ↔ 1
    3(51523594-51627015)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.203632 Transcribed sequence with weak similarity to protein more 75.36(n)    AL962070.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.166732 Transcribed sequence with weak similarity to protein more 75.67(n)    BI980252.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121296
    --
    28(a)
    1 ↔ 1
    2R(5920799-5922203)
    worm
    (Caenorhabditis elegans)
    Secernentea C23H3.36
    Protein C23H3.3, isoform b
    21(a)
    1 ↔ 1
    II(57670-60080)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G162201 putative eukaryotic LigT protein 44.71(n)
    32.7(a)
      820868  NM_112493.3  NP_188243.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g02318001 hypothetical protein 46.6(n)
    32.34(a)
      4325893  NM_001049033.1  NP_001042498.1 


    ENSEMBL Gene Tree for ASCC1 (if available)
    TreeFam Gene Tree for ASCC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASCC1 gene
    18/33 SIMAP similar genes for ASCC1 using alignment to 13 protein entries:     ASCC1_HUMAN (see all proteins) (see all similar genes):
    KIAA1651    SNRPF    RHBG    ARL6IP5    NLN    RPS6KA5
    COQ5    KIAA0101    TUBA1C    C12orf76    RRM2B    DOCK8
    DPP9    SEPSECS    TNNT1    VPS33A    ZNF799    C1orf143

    ASCC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2569 SNPs in ASCC1 are shown (see all 2569)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343339181,2
    C--73855628(+) GTCTC-/A/AA  
            
    AAAAA
    4 -- ds50011NA 2
    rs588973971,2
    C--73855628(+) AAAAA-/A/AA  
            
    TCAAC
    4 -- ds50011NA 2
    rs1434517371,2
    C--73867061(+) AGTTA-/CCCCCC 4 -- int10--------
    rs9213601,2
    C,F,H--73867539(-) ATGTTA/CAGATT 4 -- int17Minor allele frequency- C:0.01NS EA NA 540
    rs590900781,2
    C--73874400(+) AAAAA-/A/GGAAAC 4 -- int11NA 2
    rs1112855071,2
    F--73878056(+) GGAGGT/CAGAGC 4 -- int11Minor allele frequency- C:0.00CSA 1
    rs789499611,2
    C--73878538(+) GTCTC-/AAAAAA 4 -- int10--------
    rs1135609861,2
    C,F--73880045(+) GAATGC/TCTTTG 4 -- int11Minor allele frequency- T:0.50CSA 2
    rs3680185271,2
    C--73887422(+) GGTTT-/T/    
       TTTTT
    TTTTT
    4 -- int10--------
    rs30636651,2
    C--73887437(+) TTTTT-/TTT/  
      TTTTTT
    CCTAA
    7 -- cds1 int1 trp31NA 2

    HapMap Linkage Disequilibrium report for ASCC1 (73856274 - 73976892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ASCC1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671699CNV Deletion23128226
    esv2738385CNV Deletion23290073
    esv2667465CNV Deletion23128226
    dgv154e199CNV Deletion23128226
    esv2670261CNV Deletion23128226
    nsv508592CNV Loss20534489
    esv24033CNV Loss19812545
    nsv895720CNV Loss21882294
    nsv895718CNV Loss21882294
    nsv895721CNV Gain21882294


    Human Gene Mutation Database (HGMD): ASCC1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ASCC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ASCC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614215    OMIM disorders: --

    UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2
  • Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal
    esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett
    esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is
    gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus
    causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed
    to trigger the pathologic changes. Note=The gene represented in this entry may be involved in disease
    pathogenesis

  • 5 diseases for ASCC1:    About MalaCards
    barrett's esophagus    esophageal adenocarcinoma    adenocarcinoma    esophagitis
    alzheimer's disease


    ASCC1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ASCC1
    Human Genome Epidemiology (HuGE) Navigator: ASCC1 (2 documents)

    Export disorders for ASCC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASCC1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ASCC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel transcription coactivator complex containing activating signal cointegrator 1. (PubMed id 12077347)1, 2, 3 Jung D.-J.... Lee Y.C. (2002)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. (PubMed id 21791690)1, 2 Orloff M.... Eng C. (2011)
    4. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4 Halaschek-Wiener J....Brooks-Wilson A.R. (2009)
    5. Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1. (PubMed id 19074642)1, 2 Almeida-Vega S....Varro A. (2009)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. DNA unwinding by ASCC3 helicase is coupled to ALKBH3- dependent DNA alkylation repair and cancer cell proliferation. (PubMed id 22055184)2 Dango S....Shi Y. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51008 HGNC: 24268 AceView: ASCC1 Ensembl:ENSG00000138303 euGenes: HUgn51008
    ECgene: ASCC1 H-InvDB: ASCC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASCC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ASCC1 gene:
    Search GeneIP for patents involving ASCC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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