Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ASCC1 Gene

protein-coding   GIFtS: 54
GCID: GC10M073856

Activating Signal Cointegrator 1 Complex Subunit 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Activating Signal Cointegrator 1 Complex Subunit 11 2
ASC-1 Complex Subunit P502 3
Trip4 Complex Subunit P502 3
p502 5
ASC1p502

External Ids:    HGNC: 242681   Entrez Gene: 510082   Ensembl: ENSG000001383037   OMIM: 6142155   UniProtKB: Q8N9N23   

Export aliases for ASCC1 gene to outside databases

Previous GC identifers: GC10M073201 GC10M073526 GC10M067850


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ASCC1 Gene:
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a
transcriptional coactivator that plays an important role in gene transactivation by multiple transcription
factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF).
The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation
by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma.
Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. (provided by
RefSeq, Dec 2011)

GeneCards Summary for ASCC1 Gene:
ASCC1 (activating signal cointegrator 1 complex subunit 1) is a protein-coding gene. Diseases associated with ASCC1 include barrett's esophagus, and barrett esophagus/esophageal adenocarcinoma. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2
Function: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine
signals, it is involved in the induction of SERPINB2 expression by gastrin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASCC1 gene promoter:
         TBP   AhR   NRSF form 1   NRSF form 2   Arnt   AREB6   SRY   TFIID   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASCC1 promoter sequence
   Search Chromatin IP Primers for ASCC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASCC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10pter-q25.3   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

ASCC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASCC1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M073856:  view genomic region     (about GC identifiers)

Start:
73,856,274 bp from pter      End:
73,976,892 bp from pter
Size:
120,619 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2 (See protein sequence)
Recommended Name: Activating signal cointegrator 1 complex subunit 1  
Size: 400 amino acids; 45509 Da
Subunit: Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKHB3
Sequence caution: Sequence=CAI15908.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5SW06 Q5SW07 Q96EI8 Q9Y307
Alternative splicing: 2 isoforms:  Q8N9N2-1   Q8N9N2-2   

Explore the universe of human proteins at neXtProt for ASCC1: NX_Q8N9N2

Explore proteomics data for ASCC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys331
  • Modification sites at PhosphoSitePlus

  • See ASCC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001185727.1  NP_001185728.1  NP_001185729.1  

    ENSEMBL proteins: 
     ENSP00000339404   ENSP00000320810   ENSP00000431299   ENSP00000436409   ENSP00000320461  
     ENSP00000435147   ENSP00000436098   ENSP00000435191   ENSP00000431255   ENSP00000432418  
     ENSP00000431573   ENSP00000434468   ENSP00000431419   ENSP00000431746   ENSP00000442121  
     ENSP00000378377   ENSP00000378373  

    ASCC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ASCC1
    OriGene Protein Over-expression Lysate for ASCC1
    OriGene MassSpec for ASCC1
    OriGene Custom Protein Services for ASCC1
    GenScript Custom Purified and Recombinant Proteins Services for ASCC1
    Novus Biologicals ASCC1 Proteins
    Novus Biologicals ASCC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ASCC1
    Cloud-Clone Corp. Proteins for ASCC1

    ASCC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ASCC1
    OriGene Custom Antibody Services for ASCC1
    Novus Biologicals ASCC1 Antibodies
    Abcam antibodies for ASCC1
    Cloud-Clone Corp. Antibodies for ASCC1
    ThermoFisher Antibodies for ASCC1
    LSBio Antibodies in human, mouse, rat for ASCC1

    ASCC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ASCC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ASCC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ASCC1
    Cloud-Clone Corp. CLIAs for ASCC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR019510 Kinase-A_anchor_nucl_local_sig
     IPR004087 KH_dom
     IPR004088 KH_dom_type_1
     IPR009210 Euk_LigT
     IPR009097 RNA_ligase/cNuc_Pdiesterase

    Graphical View of Domain Structure for InterPro Entry Q8N9N2

    ProtoNet protein and cluster: Q8N9N2

    2 Blocks protein domains:
    IPB004087 KH domain
    IPB004088 KH


    UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2
    Similarity: Contains 1 KH domain


    ASCC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASCC1_HUMAN, Q8N9N2
    Function: Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine
    signals, it is involved in the induction of SERPINB2 expression by gastrin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003824catalytic activity IEA--
         
    ASCC1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASCC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASCC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASCC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASCC1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ASCC1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ASCC1:
    hsa-miR-520f hsa-miR-3065-3p hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidASCC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ASCC1
    Predesigned siRNA for gene silencing in human, mouse, rat ASCC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ASCC1

    Clone
    Products:
         
    OriGene clones in human, mouse for ASCC1 (see all 11)
    OriGene ORF clones in mouse, rat for ASCC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ASCC1 (NM_015947)
    Sino Biological Human cDNA Clone for ASCC1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASCC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCC1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ASCC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ASCC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ASCC1_HUMAN, Q8N9N2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex IDA12077347
    GO:0005737cytoplasm IEA--

    ASCC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASCC1
    Interactions:

        Search GeneGlobe Interaction Network for ASCC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ASCC1 (Q8N9N23 ENSP000003204614) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASCC3Q8N3C03, ENSP000003202524I2D: score=1 STRING: ENSP00000320252
    JUNP054123, ENSP000003602664I2D: score=1 STRING: ENSP00000360266
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    SRFP118313, ENSP000002653544I2D: score=1 STRING: ENSP00000265354
    NCOA6Q146863, ENSP000003518944I2D: score=1 STRING: ENSP00000351894
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA12077347

    ASCC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASCC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ASCC1 gene (4 alternative transcripts): 
    NM_001198798.2  NM_001198799.2  NM_001198800.2  NM_015947.3  

    Unigene Cluster for ASCC1:

    Activating signal cointegrator 1 complex subunit 1
    Hs.500007  [show with all ESTs]
    Unigene Representative Sequence: NM_001198799
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000342444(uc001jsr.2 uc001jst.2) ENST00000317168(uc001jsu.2)
    ENST00000534259 ENST00000486689 ENST00000530394 ENST00000317126 ENST00000525286
    ENST00000526801 ENST00000531048 ENST00000461369 ENST00000530461 ENST00000527593
    ENST00000524829 ENST00000532011 ENST00000526751 ENST00000492502 ENST00000533958
    ENST00000545550
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ASCC1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ASCC1:
    hsa-miR-520f hsa-miR-3065-3p hsa-miR-3657
    SwitchGear 3'UTR luciferase reporter plasmidASCC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ASCC1
    Predesigned siRNA for gene silencing in human, mouse, rat ASCC1
    Clone
    Products:
         
    OriGene clones in human, mouse for ASCC1 (see all 11)
    OriGene ORF clones in mouse, rat for ASCC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): ASCC1 (NM_015947)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASCC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCC1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ASCC1
    OriGene qSTAR qPCR primer pairs in human, mouse for ASCC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASCC1
      QuantiTect SYBR Green Assays in human, mouse, rat ASCC1
      QuantiFast Probe-based Assays in human, mouse, rat ASCC1

    Additional mRNA sequence: 

    AF132952.1 AK023436.1 AK093971.1 AK094170.1 AK096409.1 AK124364.1 AK298302.1 AL359339.1 
    AY013290.1 BC012291.1 NR_045564.1 

    Selected DOTS entries (see all 25):

    DT.95137233  DT.100798146  DT.121298981  DT.100675854  DT.100798141  DT.449768  DT.91882785  DT.100798143 
    DT.92449647  DT.100649903  DT.100798147  DT.92327556  DT.100024808  DT.86839587  DT.100038625  DT.100798140 
    DT.121299053  DT.100038624  DT.121298986  DT.121299003  DT.95137235  DT.100822174  DT.75170944  DT.92449652 

    Selected AceView cDNA sequences (see all 190):

    CD172350 BU181425 F10524 BG575282 CR619307 AA282796 F02489 BI918953 
    AA394161 AI638179 AL524871 BU623884 AA177055 BX393616 BM795575 BF513299 
    AA143228 CR604423 CR602037 AL529901 AI432984 BX437780 AW953786 BP376384 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ASCC1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                        -                                       
    SP2:                          -                             -                 -     -               
    SP3:                                                        -                 -                     
    SP4:                                                                          -     -               


    ECgene alternative splicing isoforms for ASCC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ASCC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGTACCAC
    ASCC1 Expression
    About this image

    ASCC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASCC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500007

    UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for ASCC1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ASCC1
    OriGene qSTAR qPCR primer pairs in human, mouse for ASCC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASCC1
    QuantiTect SYBR Green Assays in human, mouse, rat ASCC1
    QuantiFast Probe-based Assays in human, mouse, rat ASCC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASCC1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ascc11 , 5 activating signal cointegrator 1 complex subunit 11, 5 83.61(n)1
    86.8(a)1
      10 (29.67 cM)5
    690901  NM_026937.31  NP_081213.11 
     600028055 
    chicken
    (Gallus gallus)
    Aves ASCC11 activating signal cointegrator 1 complex subunit 1 69.82(n)
    69.09(a)
      423709  XM_004942039.1  XP_004942096.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASCC16
    activating signal cointegrator 1 complex subunit 1...
    59(a)
    1 ↔ 1
    3(51523594-51627015)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.203632 Transcribed sequence with weak similarity to protein more 75.36(n)    AL962070.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.166732 Transcribed sequence with weak similarity to protein more 75.67(n)    BI980252.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121296
    --
    29(a)
    1 ↔ 1
    2R(5920799-5922203)
    worm
    (Caenorhabditis elegans)
    Secernentea C23H3.36
    Protein C23H3.3, isoform a (C23H3.3) mRNA, complet...
    22(a)
    1 ↔ 1
    II(57670-60080) WBGene00016019
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G162301 AT3G16230 46.11(n)
    34.44(a)
      820869  NM_001202981.1  NP_001189910.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02319001 Os01g0231900 43.65(n)
    31.29(a)
      4325894  NM_001049034.1  NP_001042499.1 


    ENSEMBL Gene Tree for ASCC1 (if available)
    TreeFam Gene Tree for ASCC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ASCC1 gene
    Selected SIMAP similar genes for ASCC1 using alignment to 13 protein entries:     ASCC1_HUMAN (see all proteins) (see all similar genes):
    KIAA1651    SNRPF    RHBG    LINC00999    ARL6IP5    NLN
    RPS6KA5    COQ5    TM2D1    TUBA1C    C12orf76    RRM2B
    DOCK8    DPP9    SEPSECS    TNNT1    VPS33A    ZNF799

    ASCC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ASCC1 (see all 2569)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343339181,2
    C--73855628(+) GTCTC-/A/AA  
            
    AAAAA
    4 -- ds50011NA 2
    rs588973971,2
    C--73855628(+) AAAAA-/A/AA  
            
    TCAAC
    4 -- ds50011NA 2
    rs1434517371,2
    C--73867061(+) AGTTA-/CCCCCC 4 -- int10--------
    rs9213601,2
    C,F,H--73867539(-) ATGTTA/CAGATT 4 -- int17Minor allele frequency- C:0.01NS EA NA 540
    rs590900781,2
    C--73874400(+) AAAAA-/A/GGAAAC 4 -- int11NA 2
    rs1112855071,2
    F--73878056(+) GGAGGT/CAGAGC 4 -- int11Minor allele frequency- C:0.00CSA 1
    rs789499611,2
    C--73878538(+) GTCTC-/AAAAAA 4 -- int10--------
    rs1135609861,2
    C,F--73880045(+) GAATGC/TCTTTG 4 -- int11Minor allele frequency- T:0.50CSA 2
    rs3680185271,2
    C--73887422(+) GGTTT-/T/    
       TTTTT
    TTTTT
    4 -- int10--------
    rs30636651,2
    C--73887437(+) TTTTT-/TTT/  
      TTTTTT
    CCTAA
    7 -- cds1 int1 trp31NA 2

    HapMap Linkage Disequilibrium report for ASCC1 (73856274 - 73976892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ASCC1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671699CNV Deletion23128226
    esv2738385CNV Deletion23290073
    esv2667465CNV Deletion23128226
    dgv154e199CNV Deletion23128226
    esv2670261CNV Deletion23128226
    nsv508592CNV Loss20534489
    esv24033CNV Loss19812545
    nsv895720CNV Loss21882294
    nsv895718CNV Loss21882294
    nsv895721CNV Gain21882294

    Human Gene Mutation Database (HGMD): ASCC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASCC1
    DNA2.0 Custom Variant and Variant Library Synthesis for ASCC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614215   
    OMIM disorders: 614266  
    UniProtKB/Swiss-Prot: ASCC1_HUMAN, Q8N9N2
  • Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal
    esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett
    esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is
    gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus
    causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed
    to trigger the pathologic changes. Note=The gene represented in this entry may be involved in disease
    pathogenesis

  • 8 diseases for ASCC1:    
    About MalaCards
    barrett's esophagus    barrett esophagus/esophageal adenocarcinoma    esophagitis    adenocarcinoma
    alzheimer's disease    multiple myeloma    myeloma    malaria


    ASCC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ASCC1
    Human Genome Epidemiology (HuGE) Navigator: ASCC1 (2 documents)

    Export disorders for ASCC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ASCC1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with ASCC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel transcription coactivator complex containing activating signal cointegrator 1. (PubMed id 12077347)1, 2, 3 Jung D.-J.... Lee Y.C. (Mol. Cell. Biol. 2002)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. (PubMed id 21791690)1, 2 Orloff M.... Eng C. (JAMA 2011)
    4. Genetic variation in healthy oldest-old. (PubMed id 19680556)1, 4 Halaschek-Wiener J....Brooks-Wilson A.R. (PLoS ONE 2009)
    5. Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1. (PubMed id 19074642)1, 2 Almeida-Vega S.... Varro A. (Am. J. Physiol. 2009)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51008 HGNC: 24268 AceView: ASCC1 Ensembl:ENSG00000138303 euGenes: HUgn51008
    ECgene: ASCC1 H-InvDB: ASCC1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ASCC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ASCC1 gene:
    Search GeneIP for patents involving ASCC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ASCC1   OriGene RNAi products in human, mouse, rat for ASCC1  
     OriGene qPCR primer pairs and template standards for ASCC1   OriGene Protein Over-expression Lysate for ASCC1  
     OriGene MassSpec something-or-other for ASCC1   OriGene clones in human, mouse for ASCC1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ASCC1   OriGene Purified Protein for ASCC1  
     OriGene ORF clones in mouse, rat for ASCC1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ASCC1   OriGene Custom Protein Services for ASCC1  

     
     
     Block miRNA regulation of human, mouse, rat ASCC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ASCC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASCC1 Predesigned siRNA for gene silencing in human, mouse, rat ASCC1
     QuantiFast Probe-based Assays in human, mouse, rat ASCC1 QuantiTect SYBR Green Assays in human, mouse, rat ASCC1
     Custom PCR Arrays for ASCC1 Search Chromatin IP Primers for ASCC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASCC1  Search GeneGlobe Interaction Network for ASCC1
     Regulatory tfbs in ASCC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ASCC1 GenScript cDNA clones with any tag delivered in your preferred vector for ASCC1
     GenScript Custom Assay Services for ASCC1 GenScript Custom overexpressing Cell Line Services for ASCC1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ASCC1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ASCC1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ASCC1 antibodies
     ASCC1 proteins
     ASCC1 lysates
     Antibodies for ASCC1
     See all of Abcam's Antibodies, Kits and Proteins for ASCC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ASCC1
     Proteins for ASCC1
     Antibodies for ASCC1
     ELISAs for ASCC1
     CLIAs for ASCC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for ASCC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASCC1
     SwitchGear 3'UTR luciferase reporter plasmids for ASCC1
     SwitchGear Promoter luciferase reporter plasmids for ASCC1
     ThermoFisher Antibodies for ASCC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASCC1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASCC1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASCC1
     LSBio Antibodies in human, mouse, rat for ASCC1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ASCC1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4