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Aliases for ASB9 Gene

Aliases for ASB9 Gene

  • Ankyrin Repeat And SOCS Box Containing 9 2 3
  • Ankyrin Repeat And SOCS Box-Containing 9 2 3
  • ASB-9 3 4
  • Ankyrin Repeat And Suppressor Of Cytokine Signaling Box Protein 9 3
  • Ankyrin Repeat And SOCS Box Protein 9 3

External Ids for ASB9 Gene

Summaries for ASB9 Gene

Entrez Gene Summary for ASB9 Gene

  • This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for ASB9 Gene

ASB9 (Ankyrin Repeat And SOCS Box Containing 9) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.

UniProtKB/Swiss-Prot for ASB9 Gene

  • Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB9 Gene

Genomics for ASB9 Gene

Genomic Location for ASB9 Gene

Start:
15,235,288 bp from pter
End:
15,270,467 bp from pter
Size:
35,180 bases
Orientation:
Minus strand

Genomic View for ASB9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB9 Gene

Regulatory Elements for ASB9 Gene

Proteins for ASB9 Gene

  • Protein details for ASB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DX5-ASB9_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 9
    Protein Accession:
    Q96DX5
    Secondary Accessions:
    • A8K8A5
    • Q9BVF5
    • Q9NWS5
    • Q9Y4T3

    Protein attributes for ASB9 Gene

    Size:
    294 amino acids
    Molecular mass:
    31858 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB45706.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ASB9 Gene

    Alternative splice isoforms for ASB9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB9 Gene

Proteomics data for ASB9 Gene at MOPED

Post-translational modifications for ASB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB9 Gene

No data available for DME Specific Peptides for ASB9 Gene

Domains for ASB9 Gene

Gene Families for ASB9 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB9 Gene

UniProtKB/Swiss-Prot:

ASB9_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.:
    • Q96DX5
  • Contains 1 SOCS box domain.:
    • Q96DX5
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.:
    • Q96DX5
Similarity:
  • Contains 6 ANK repeats.:
    • Q96DX5
genes like me logo Genes that share domains with ASB9: view

Function for ASB9 Gene

Molecular function for ASB9 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.

Gene Ontology (GO) - Molecular Function for ASB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ASB9: view

Phenotypes for ASB9 Gene

GenomeRNAi human phenotypes for ASB9:
genes like me logo Genes that share phenotypes with ASB9: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASB9 Gene

Localization for ASB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASB9 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB9 Gene COMPARTMENTS Subcellular localization image for ASB9 gene
Compartment Confidence
mitochondrion 5
cytosol 4
nucleus 4
extracellular 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ASB9: view

Pathways for ASB9 Gene

genes like me logo Genes that share pathways with ASB9: view

UniProtKB/Swiss-Prot Q96DX5-ASB9_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0045732 positive regulation of protein catabolic process IDA 17148442
genes like me logo Genes that share ontologies with ASB9: view

Transcripts for ASB9 Gene

Unigene Clusters for ASB9 Gene

Ankyrin repeat and SOCS box containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - -
SP8: -
SP9:

Relevant External Links for ASB9 Gene

GeneLoc Exon Structure for
ASB9
ECgene alternative splicing isoforms for
ASB9

Expression for ASB9 Gene

mRNA expression in normal human tissues for ASB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB9 Gene

This gene is overexpressed in Testis (14.7) and Spleen (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASB9 Gene

SOURCE GeneReport for Unigene cluster for ASB9 Gene Hs.19404

mRNA Expression by UniProt/SwissProt for ASB9 Gene

Q96DX5-ASB9_HUMAN
Tissue specificity: Predominantly expressed in testis, kidney, and liver.
genes like me logo Genes that share expressions with ASB9: view

Orthologs for ASB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
OneToMany
-- 37
  • 100 (a)
OneToMany
LOC100609711 36
  • 99.66 (n)
  • 99.66 (a)
cow
(Bos Taurus)
Mammalia ASB9 36
  • 81.88 (n)
  • 77.35 (a)
ASB9 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB9 36
  • 79.27 (n)
  • 79.73 (a)
ASB9 37
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb9 36
  • 77.13 (n)
  • 75.17 (a)
Asb9 16
Asb9 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASB9 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB9 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb9 36
  • 77.24 (n)
  • 76.55 (a)
chicken
(Gallus gallus)
Aves ASB9 36
  • 69.8 (n)
  • 65.85 (a)
ASB9 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
OneToMany
-- 37
  • 62 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.8986 36
tropical clawed frog
(Silurana tropicalis)
Amphibia asb9 36
  • 61.31 (n)
  • 57.69 (a)
Str.10451 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4234 37
  • 31 (a)
OneToMany
Species with no ortholog for ASB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ASB9 Gene

ENSEMBL:
Gene Tree for ASB9 (if available)
TreeFam:
Gene Tree for ASB9 (if available)

Paralogs for ASB9 Gene

Paralogs for ASB9 Gene

Selected SIMAP similar genes for ASB9 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ASB9 Gene

genes like me logo Genes that share paralogs with ASB9: view

Variants for ASB9 Gene

Sequence variations from dbSNP and Humsavar for ASB9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs9560 -- 15,244,250(-) CCTGC(A/T)TGGAG utr-variant-3-prime, downstream-variant-500B
rs14252 -- 15,244,310(-) AGGGT(G/T)GAAAG utr-variant-3-prime
rs731197 -- 15,249,126(-) TACAT(A/C/T)CAATA intron-variant
rs899646 -- 15,270,071(+) AGGCA(C/T)GCGCT utr-variant-5-prime, intron-variant
rs899647 -- 15,270,297(+) TGAAG(A/G)AAACA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ASB9 Gene

Variant ID Type Subtype PubMed ID
nsv528005 CNV Gain 19592680
esv1774504 CNV Insertion 17803354

Relevant External Links for ASB9 Gene

HapMap Linkage Disequilibrium report
ASB9
Locus Specific Mutation Databases (LSDB)
ASB9

Disorders for ASB9 Gene

No disorders were found for ASB9 Gene.

No data available for UniProtKB/Swiss-Prot for ASB9 Gene

Publications for ASB9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Crystal structure of human ASB9-2 and substrate-recognition of CKB. (PMID: 22418839) Fei X. … Ji C. (Protein J. 2012) 3 4
  4. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  5. ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function. (PMID: 20302626) Kwon S. … Kwon H.J. (BMC Biol. 2010) 3 4

Products for ASB9 Gene

Sources for ASB9 Gene

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