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Aliases for ASB9 Gene

Aliases for ASB9 Gene

  • Ankyrin Repeat And SOCS Box Containing 9 2 3 5
  • ASB-9 3 4
  • Ankyrin Repeat And Suppressor Of Cytokine Signaling Box Protein 9 3
  • Testis Tissue Sperm-Binding Protein Li 57p 3
  • Ankyrin Repeat And SOCS Box-Containing 9 2
  • Ankyrin Repeat And SOCS Box Protein 9 3

External Ids for ASB9 Gene

Previous GeneCards Identifiers for ASB9 Gene

  • GC00U991143
  • GC0XM014087
  • GC0XM014464
  • GC0XM014623
  • GC0XM015021
  • GC0XM015172
  • GC0XM013019

Summaries for ASB9 Gene

Entrez Gene Summary for ASB9 Gene

  • This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for ASB9 Gene

ASB9 (Ankyrin Repeat And SOCS Box Containing 9) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is ASB11.

UniProtKB/Swiss-Prot for ASB9 Gene

  • Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB9 Gene

Genomics for ASB9 Gene

Regulatory Elements for ASB9 Gene

Enhancers for ASB9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ASB9 on UCSC Golden Path with GeneCards custom track

Promoters for ASB9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ASB9 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB9 Gene

Chromosome:
X
Start:
15,235,288 bp from pter
End:
15,270,467 bp from pter
Size:
35,180 bases
Orientation:
Minus strand

Genomic View for ASB9 Gene

Genes around ASB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB9 Gene

Proteins for ASB9 Gene

  • Protein details for ASB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DX5-ASB9_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 9
    Protein Accession:
    Q96DX5
    Secondary Accessions:
    • A8K8A5
    • Q9BVF5
    • Q9NWS5
    • Q9Y4T3

    Protein attributes for ASB9 Gene

    Size:
    294 amino acids
    Molecular mass:
    31858 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB45706.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ASB9 Gene

    Alternative splice isoforms for ASB9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB9 Gene

Post-translational modifications for ASB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASB9 Gene

Domains & Families for ASB9 Gene

Gene Families for ASB9 Gene

Protein Domains for ASB9 Gene

Suggested Antigen Peptide Sequences for ASB9 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DX5

UniProtKB/Swiss-Prot:

ASB9_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 6 ANK repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ASB9: view

Function for ASB9 Gene

Molecular function for ASB9 Gene

UniProtKB/Swiss-Prot Function:
Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.

Gene Ontology (GO) - Molecular Function for ASB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with ASB9: view

Phenotypes for ASB9 Gene

genes like me logo Genes that share phenotypes with ASB9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB9 Gene

Localization for ASB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASB9 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB9 Gene COMPARTMENTS Subcellular localization image for ASB9 gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 3
extracellular 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ASB9: view

Pathways & Interactions for ASB9 Gene

genes like me logo Genes that share pathways with ASB9: view

UniProtKB/Swiss-Prot Q96DX5-ASB9_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0045732 positive regulation of protein catabolic process IDA 17148442
genes like me logo Genes that share ontologies with ASB9: view

No data available for SIGNOR curated interactions for ASB9 Gene

Drugs & Compounds for ASB9 Gene

No Compound Related Data Available

Transcripts for ASB9 Gene

Unigene Clusters for ASB9 Gene

Ankyrin repeat and SOCS box containing 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - -
SP8: -
SP9:

Relevant External Links for ASB9 Gene

GeneLoc Exon Structure for
ASB9
ECgene alternative splicing isoforms for
ASB9

Expression for ASB9 Gene

mRNA expression in normal human tissues for ASB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB9 Gene

This gene is overexpressed in Testis (x14.7) and Spleen (x5.3).

Protein differential expression in normal tissues from HIPED for ASB9 Gene

This gene is overexpressed in Testis (40.3) and Ovary (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ASB9 Gene



Protein tissue co-expression partners for ASB9 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB9 Gene:

ASB9

SOURCE GeneReport for Unigene cluster for ASB9 Gene:

Hs.19404

mRNA Expression by UniProt/SwissProt for ASB9 Gene:

Q96DX5-ASB9_HUMAN
Tissue specificity: Predominantly expressed in testis, kidney, and liver.
genes like me logo Genes that share expression patterns with ASB9: view

Primer Products

Orthologs for ASB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASB9 34
  • 81.88 (n)
  • 77.35 (a)
ASB9 35
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB9 34
  • 79.27 (n)
  • 79.73 (a)
ASB9 35
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb9 34
  • 77.13 (n)
  • 75.17 (a)
Asb9 16
Asb9 35
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100609711 34
  • 99.66 (n)
  • 99.66 (a)
-- 35
  • 100 (a)
OneToMany
-- 35
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Asb9 34
  • 77.24 (n)
  • 76.55 (a)
oppossum
(Monodelphis domestica)
Mammalia ASB9 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB9 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB9 34
  • 69.8 (n)
  • 65.85 (a)
ASB9 35
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia asb9 34
  • 61.31 (n)
  • 57.69 (a)
Str.10451 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8986 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4234 35
  • 31 (a)
OneToMany
Species where no ortholog for ASB9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ASB9 Gene

ENSEMBL:
Gene Tree for ASB9 (if available)
TreeFam:
Gene Tree for ASB9 (if available)

Paralogs for ASB9 Gene

Paralogs for ASB9 Gene

(12) SIMAP similar genes for ASB9 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ASB9 Gene

genes like me logo Genes that share paralogs with ASB9: view

Variants for ASB9 Gene

Sequence variations from dbSNP and Humsavar for ASB9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747728808 -- 15,263,695(+) TCACC(A/C)CTCCT intron-variant
rs747780209 -- 15,254,602(+) GATGA(A/G)CATAA intron-variant
rs747826732 -- 15,252,380(+) AGTGT(A/G)CCAGT intron-variant, reference, missense
rs747877005 -- 15,247,091(+) GAAAC(A/G)GGTGG intron-variant
rs747883573 -- 15,261,374(+) TTTTT(C/T)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB9 Gene

Variant ID Type Subtype PubMed ID
dgv2226e212 CNV loss 25503493
dgv2227e212 CNV loss 25503493
esv1774504 CNV insertion 17803354
esv3573602 CNV loss 25503493
nsv528005 CNV gain 19592680

Variation tolerance for ASB9 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB9 Gene

Disorders for ASB9 Gene

Relevant External Links for ASB9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB9

No disorders were found for ASB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB9 Gene

Publications for ASB9 Gene

  1. Crystal structure of human ASB9-2 and substrate-recognition of CKB. (PMID: 22418839) Fei X. … Ji C. (Protein J. 2012) 3 4 65
  2. ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function. (PMID: 20302626) Kwon S. … Kwon H.J. (BMC Biol. 2010) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 65

Products for ASB9 Gene

Sources for ASB9 Gene

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