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ASB9 Gene

protein-coding   GIFtS: 55
GCID: GC0XM015252

Ankyrin Repeat And SOCS Box Containing 9

(Previous name: ankyrin repeat and SOCS box-containing 9)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And SOCS Box Containing 91 2
Ankyrin Repeat And SOCS Box-Containing 91 2
ASB-92 3
Ankyrin Repeat And SOCS Box Protein 92
Ankyrin Repeat And Suppressor Of Cytokine Signaling Box Protein 92

External Ids:    HGNC: 171841   Entrez Gene: 1404622   Ensembl: ENSG000001020487   OMIM: 3008905   UniProtKB: Q96DX53   

Export aliases for ASB9 gene to outside databases

Previous GC identifers: GC00U991143 GC0XM014087 GC0XM014464 GC0XM014623 GC0XM015021 GC0XM015172 GC0XM013019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASB9 Gene:
This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family.
Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further
complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate
the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified
on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Dec 2009)

GeneCards Summary for ASB9 Gene:
ASB9 (ankyrin repeat and SOCS box containing 9) is a protein-coding gene. Diseases associated with ASB9 include colorectal cancer. An important paralog of this gene is ASB13.

UniProtKB/Swiss-Prot: ASB9_HUMAN, Q96DX5
Function: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein
ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Recognizes at least two forms of creatine kinase, CKB and CKMT1A




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASB9 gene promoter:
         TBP   POU2F1   POU2F1a   aMEF-2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASB9 promoter sequence
   Search Chromatin IP Primers for ASB9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.2

ASB9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB9 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM015252:  view genomic region     (about GC identifiers)

Start:
15,253,410 bp from pter      End:
15,288,589 bp from pter
Size:
35,180 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ASB9_HUMAN, Q96DX5 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 9  
Size: 294 amino acids; 31858 Da
Sequence caution: Sequence=CAB45706.2; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for ASB9:
3D9H (3D)        3ZKJ (3D)        3ZNG (3D)    
Secondary accessions: A8K8A5 Q9BVF5 Q9NWS5 Q9Y4T3
Alternative splicing: 3 isoforms:  Q96DX5-1   Q96DX5-2   Q96DX5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASB9: NX_Q96DX5

Explore proteomics data for ASB9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ASB9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001026909.1  NP_001162002.1  NP_001162003.1  NP_076992.1  

    ENSEMBL proteins: 
     ENSP00000473542   ENSP00000369850   ENSP00000369852   ENSP00000369855   ENSP00000438943  
    Reactome Protein details: Q96DX5

    ASB9 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR001496 SOCS_C
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q96DX5

    ProtoNet protein and cluster: Q96DX5

    2 Blocks protein domains:
    IPB001496 SOCS protein
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ASB9_HUMAN, Q96DX5
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin-protein ligase complexes (By similarity)
    Similarity: Contains 6 ANK repeats
    Similarity: Contains 1 SOCS box domain


    ASB9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASB9_HUMAN, Q96DX5
    Function: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein
    ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    Recognizes at least two forms of creatine kinase, CKB and CKMT1A

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    ASB9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASB9:
     Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASB9
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    Inhib. RNA
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    Sino Biological Human cDNA Clone for ASB9
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASB9_HUMAN, Q96DX5: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    nucleus4
    extracellular1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--

    ASB9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASB9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ASB9
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: ASB9_HUMAN, Q96DX5
    Pathway: Protein modification; protein ubiquitination


    ASB9 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ASB9: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ASB9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ASB9 (Q96DX51, 2, 3 ENSP000003698554) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CKBP122771, 2, 3, ENSP000002991984EBI-745641,EBI-357706 MINT-66916 I2D: score=4 STRING: ENSP00000299198
    HIF1ANQ9NWT61, 2, 3, ENSP000002991634EBI-745641,EBI-745632 MINT-66697 I2D: score=4 STRING: ENSP00000299163
    CKMT1BP125323, ENSP000003002834I2D: score=2 STRING: ENSP00000300283
    CKMT1AP125323I2D: score=2 
    TCEB2Q153703, ENSP000002623064I2D: score=1 STRING: ENSP00000262306
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--
    GO:0045732positive regulation of protein catabolic process IDA17148442

    ASB9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASB9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ASB9 gene (4 alternative transcripts): 
    NM_001031739.2  NM_001168530.1  NM_001168531.1  NM_024087.2  

    Unigene Cluster for ASB9:

    Ankyrin repeat and SOCS box containing 9
    Hs.19404  [show with all ESTs]
    Unigene Representative Sequence: NM_001168531
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477346 ENST00000380483 ENST00000380485(uc004cwn.2) ENST00000380488(uc004cwm.3 uc004cwk.3 uc004cwl.3)
    ENST00000473862 ENST00000481384 ENST00000484017 ENST00000470015 ENST00000546332(uc010ner.3)

    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): ASB9 (NM_001031739)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB9
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB9
      QuantiTect SYBR Green Assays in human, mouse, rat ASB9
      QuantiFast Probe-based Assays in human, mouse, rat ASB9

    Additional mRNA sequence: 

    AK000643.1 AK292270.1 AL080091.2 AY337578.1 BC001244.1 BC013172.1 

    7 DOTS entries:

    DT.309411  DT.95171274  DT.100747335  DT.100747334  DT.121285541  DT.100747336  DT.95296405 

    Selected AceView cDNA sequences (see all 102):

    BP368833 CA776490 BQ676272 BI791549 BM565113 BI826191 CA866687 BF197467 
    BI826838 BX117678 AA884915 BQ127908 AI014432 BQ683510 BU579623 AI474528 
    BU070590 BQ682929 BC001244 CA866945 BM508152 BG779885 AI538164 BI222794 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ASB9 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b
    SP1:                                            -                                   -                                               -               
    SP2:                                            -                                   -                                                               
    SP3:                                            -                                   -     -                                                         
    SP4:        -     -     -     -                 -                                   -                                                               
    SP5:                                            -                       -           -                                                               


    ECgene alternative splicing isoforms for ASB9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASB9 expression in normal human tissues (normalized intensities)      ASB9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGCACTT
    ASB9 Expression
    About this image


    ASB9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
     
     Blood (Hematopoietic System)
             Megakaryocyte-Erythroid Precursor Cells Hematopoietic Bone Marrow
     
     Kidney (Urinary System)
    ASB9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASB9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.19404

    UniProtKB/Swiss-Prot: ASB9_HUMAN, Q96DX5
    Tissue specificity: Predominantly expressed in testis, kidney, and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including ASB9: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ASB9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ASB9 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asb91 , 5 ankyrin repeat and SOCS box-containing 91, 5 77.13(n)1
    75.17(a)1
      X (76.73 cM)5
    692991  NM_027027.21  NP_081303.11 
     1645063275 
    chicken
    (Gallus gallus)
    Aves ASB91 ankyrin repeat and SOCS box containing 9 69.8(n)
    65.85(a)
      418625  NM_001006262.1  NP_001006262.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    62(a)
    62(a)
    1 ↔ many
    1 ↔ many
    1(206228907-206233053)
    3(121348378-121366619)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89862 Xenopus laevis transcribed sequence with weak similarity more 75.01(n)    CF548667.1 


    ENSEMBL Gene Tree for ASB9 (if available)
    TreeFam Gene Tree for ASB9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASB9 gene
    ASB132  ASB122  ASB12  ASB112  ASB52  
    12 SIMAP similar genes for ASB9 using alignment to 3 protein entries:     ASB9_HUMAN (see all proteins):
    ATL2    CCPG1    TJP1    ASB11    ASB5    DKFZp313J0816
    DKFZp779E2460    NSD1    ZNF23    RAI14    ASB13    ANKRD12

    ASB9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ASB9
    PGOHUM00000259002


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASB9 (see all 525)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834973891,2
    --15177068(+) CAAATC/TAGACA 4 -- ut310--------
    rs172163021,2
    C,F--15177136(+) AGTGAT/AGCTGG 4 -- ut31 ese33Minor allele frequency- A:0.01NA 142
    rs172163161,2
    C,F,H--15177260(+) AGGGCT/CAAATT 4 -- ut317Minor allele frequency- C:0.00NA NS EA 554
    rs95601,2
    C,F,O,A,H--15177330(-) CCTGCA/TTGGAG 4 -- ut31 ese325--MN NS EA NA WA CSA 1452
    rs142521,2
    C,F,A,H--15177390(-) AGGGTT/GGAAAG 4 -- ut3122Minor allele frequency- G:0.80MN NS EA NA WA CSA 2171
    rs1122327731,2
    F--15177489(+) AACTAG/TTCAAA 4 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1846873351,2
    --15177503(+) TATAAA/GTCCAA 4 -- ut310--------
    rs1492411041,2
    C--15177628(+) AGGACG/AAGTTT 5 /L syn1 ut311Minor allele frequency- A:0.00NA 4548
    rs1444575291,2
    F--15177630(+) GACGAG/ATTTGG 5 /L /F mis1 ut311Minor allele frequency- A:0.00NA 4548
    rs1123822421,2
    C--15177771(+) TTTTTG/-TAAAA 4 -- int11Minor allele frequency- -:0.00CSA 2

    HapMap Linkage Disequilibrium report for ASB9 (15253410 - 15288589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ASB9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1774504CNV Insertion17803354
    nsv528005CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): ASB9

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300890    OMIM disorders: --

    1 disease for ASB9:    About MalaCards
    colorectal cancer


    ASB9 for disorders           About GeneDecksing


    Export disorders for ASB9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASB9 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ASB9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of human ASB9-2 and substrate-recognition of CKB. (PubMed id 22418839)1, 2 Fei X....Ji C. (Protein J. 2012)
    2. ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function. (PubMed id 20302626)1, 2 Kwon S....Kwon H.J. (BMC Biol. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
    6. Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases. (PubMed id 23837592)1 Thomas J.C....Ciulli A. (Biochemistry 2013)
    7. Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases. (PubMed id 23806657)1 Muniz J.R....Bullock A.N. (J. Mol. Biol. 2013)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Clinical significance of ASB9 in human colorectal cancer. (PubMed id 20878058)1 Tokuoka M....Mori M. (Int. J. Oncol. 2010)
    10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140462 HGNC: 17184 AceView: ASB9 Ensembl:ENSG00000102048 euGenes: HUgn140462
    ECgene: ASB9 H-InvDB: ASB9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ASB9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ASB9 gene:
    Search GeneIP for patents involving ASB9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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