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ASB8 Gene

protein-coding   GIFtS: 51
GCID: GC12M048541

Ankyrin Repeat And SOCS Box Containing 8

(Previous name: ankyrin repeat and SOCS box-containing 8)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And SOCS Box Containing 81 2
Ankyrin Repeat And SOCS Box-Containing 81 2
ASB-82 3
Ankyrin Repeat And SOCS Box Protein 82

External Ids:    HGNC: 171831   Entrez Gene: 1404612   Ensembl: ENSG000001779817   OMIM: 6150535   UniProtKB: Q9H7653   

Export aliases for ASB8 gene to outside databases

Previous GC identifers: GC00U991142 GC12M048441 GC12M048259 GC12M046828 GC12M046827 GC12M045573


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ASB8 Gene:
ASB8 (ankyrin repeat and SOCS box containing 8) is a protein-coding gene. An important paralog of this gene is ANKRD54.

UniProtKB/Swiss-Prot: ASB8_HUMAN, Q9H765
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASB8 gene promoter:
         Max1   SRF   SRF (504 AA)   MEF-2   MyoD   HNF-3beta   MEF-2A   PPAR-gamma1   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASB8 promoter sequence
   Search Chromatin IP Primers for ASB8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13.12

ASB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048541:  view genomic region     (about GC identifiers)

Start:
48,541,571 bp from pter      End:
48,574,996 bp from pter
Size:
33,426 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASB8_HUMAN, Q9H765 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 8  
Size: 288 amino acids; 31642 Da
Secondary accessions: A8K1P2 Q547Q2

Explore the universe of human proteins at neXtProt for ASB8: NX_Q9H765

Explore proteomics data for ASB8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ASB8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077000.1  
    ENSEMBL proteins: 
     ENSP00000320893   ENSP00000445622   ENSP00000438498   ENSP00000445540   ENSP00000440773  
     ENSP00000438434   ENSP00000442737   ENSP00000444093   ENSP00000443835   ENSP00000437769  
     ENSP00000442639   ENSP00000439557   ENSP00000437530   ENSP00000443148   ENSP00000447819  
    Reactome Protein details: Q9H765

    ASB8 Human Recombinant Protein Products:

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    Novus Biologicals ASB8 Proteins
    Novus Biologicals ASB8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ASB8
    Cloud-Clone Corp. Proteins for ASB8

     
    Search eBioscience for Proteins for ASB8 

    ASB8 Antibody Products:

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    ASB8 Assay Products:

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    Cloud-Clone Corp. ELISAs for ASB8
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    Search eBioscience for ELISAs for ASB8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR001496 SOCS_C
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9H765

    ProtoNet protein and cluster: Q9H765

    1 Blocks protein domain: IPB001496 SOCS protein

    UniProtKB/Swiss-Prot: ASB8_HUMAN, Q9H765
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin-protein ligase complexes (By similarity)
    Similarity: Contains 4 ANK repeats
    Similarity: Contains 1 SOCS box domain


    Find genes that share domains with ASB8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASB8_HUMAN, Q9H765
    Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ASB8           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASB8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASB8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASB8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASB8

    miRNA
    Products:
        
    miRTarBase miRNAs that target ASB8:
    hsa-mir-615-3p (MIRT040179)

    Block miRNA regulation of human, mouse, rat ASB8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ASB8 (see all 23):
    hsa-miR-448 hsa-miR-3942-5p hsa-miR-509-5p hsa-miR-507 hsa-miR-1205 hsa-miR-583 hsa-miR-570 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmidASB8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ASB8
    Predesigned siRNA for gene silencing in human, mouse, rat ASB8

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for ASB8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ASB8 (NM_024095)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB8

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ASB8 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASB8_HUMAN, Q9H765: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with ASB8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASB8 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with ASB8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ASB8
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: ASB8_HUMAN, Q9H765
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASB8
    Interactions:

        Search GeneGlobe Interaction Network for ASB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ASB8 (Q9H7653 ENSP000003208934) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEB2Q153703, ENSP000002623064I2D: score=2 STRING: ENSP00000262306
    HOXD4P090163, ENSP000003025484I2D: score=1 STRING: ENSP00000302548
    TCEB1Q153693, ENSP000002848114I2D: score=1 STRING: ENSP00000284811
    MCM7ENSP000003072884STRING: ENSP00000307288
    RCN1ENSP000000549504STRING: ENSP00000054950
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    Find genes that share ontologies with ASB8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASB8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ASB8 gene: 
    NM_024095.3  

    Unigene Cluster for ASB8:

    Ankyrin repeat and SOCS box containing 8
    Hs.432699  [show with all ESTs]
    Unigene Representative Sequence: NM_024095
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317697(uc001rrh.3) ENST00000536549(uc010slr.2) ENST00000537754
    ENST00000536938 ENST00000536953 ENST00000539528 ENST00000535055 ENST00000539865
    ENST00000536071 ENST00000539503 ENST00000540143 ENST00000545791 ENST00000540212
    ENST00000539464 ENST00000540782 ENST00000535988 ENST00000548228
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ASB8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ASB8 (see all 23):
    hsa-miR-448 hsa-miR-3942-5p hsa-miR-509-5p hsa-miR-507 hsa-miR-1205 hsa-miR-583 hsa-miR-570 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmidASB8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ASB8
    Predesigned siRNA for gene silencing in human, mouse, rat ASB8
    Clone
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    OriGene clones in human, mouse for ASB8 (see all 7)
    OriGene ORF clones in mouse, rat for ASB8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ASB8 (NM_024095)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB8
    Primer
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    OriGene qPCR primer pairs and template standards for ASB8
    OriGene qSTAR qPCR primer pairs in human, mouse for ASB8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB8
      QuantiTect SYBR Green Assays in human, mouse, rat ASB8
      QuantiFast Probe-based Assays in human, mouse, rat ASB8

    Additional mRNA sequence: 

    AF464877.1 AK024908.1 AK289957.1 AK297013.1 BC001321.1 CR457336.1 

    10 DOTS entries:

    DT.121146199  DT.319624  DT.101965800  DT.100788942  DT.100788940  DT.100807995  DT.91735740  DT.91762663 
    DT.121146184  DT.121146210 

    15 AceView cDNA sequences:

    AK024908 AA579110 NM_024095 BC001321 AA525314 AF464877 AK125596 CR457336 
    AA525337 BX463762 AX810692 BF515355 BF987220 AW972745 BG983839 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ASB8 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h
    SP1:                                -                             -     -     -     -                                                   
    SP2:                                -           -     -           -     -     -                                                         
    SP3:                                -           -     -           -     -     -                                                         
    SP4:                                -           -     -           -     -                                                               
    SP5:                                -                             -     -     -     -                                                   


    ECgene alternative splicing isoforms for ASB8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASB8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ASB8 Expression
    About this image


    ASB8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ASB8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASB8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432699

    UniProtKB/Swiss-Prot: ASB8_HUMAN, Q9H765
    Tissue specificity: Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta,
    liver, kidney and pancreas

        Custom PCR Arrays for ASB8
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    QuantiTect SYBR Green Assays in human, mouse, rat ASB8
    QuantiFast Probe-based Assays in human, mouse, rat ASB8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ASB8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asb81 , 5 ankyrin repeat and SOCS box-containing 81, 5 90.16(n)1
    97.22(a)1
      15 (54.13 cM)5
    785411  NM_001170710.11  NP_001164181.11 
     981346375 
    chicken
    (Gallus gallus)
    Aves ASB81 ankyrin repeat and SOCS box containing 8 69.14(n)
    76.95(a)
      426183  NM_001012936.1  NP_001012954.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASB86
    ankyrin repeat and SOCS box containing 8
    78(a)
    1 ↔ 1
    GL343536.1(88805-120017)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162502 Xenopus laevis transcribed sequence with weak similarity more 73.03(n)    BX850322.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd16d082 wufd16d08 72.73(n)   327200  BC053213.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAS66
    Proteasome-interacting protein involved in the ass...
    22(a)
    1 → many
    VII(953960-954646) YGR232W


    ENSEMBL Gene Tree for ASB8 (if available)
    TreeFam Gene Tree for ASB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASB8 gene
    ANKRD542  PSMD102  ANKRD422  ASB72  
    7 SIMAP similar genes for ASB8 using alignment to 11 protein entries:     ASB8_HUMAN (see all proteins):
    ANKRD44    ANKRD65    DKFZp761E1322    MTPN    ASB16    ANKRD46
    ANKRD6

    Find genes that share paralogs with ASB8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASB8 (see all 280)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1432569721,2
    --48541089(+) CTTTGA/GACCAA 1 -- int10--------
    rs102195201,2
    C,F,H--48541320(+) agtgaT/Ctttat 1 -- int17Minor allele frequency- C:0.02NS EA NA WA 744
    rs1922411271,2
    --48541328(+) TATGTA/GCAGCT 1 -- int10--------
    rs1115083111,2
    C,F--48541382(+) AGAAGG/TTATAA 1 -- int14Minor allele frequency- T:0.04NA CSA WA 124
    rs1482935301,2
    C--48541411(+) AGATAC/TTCTGC 1 -- int10--------
    rs1511142481,2
    C--48541530(+) TCTAA-/GGGGGG 1 -- int10--------
    rs1416013091,2
    --48541733(+) CAAATG/TTGCAT 1 -- ut310--------
    rs88041,2
    C,F,A,H--48541757(+) AATCAA/GTAACA 1 -- ut3128Minor allele frequency- G:0.17MN EA NA NS WA 3162
    rs1833700531,2
    --48541769(+) CTTGAC/TCTAAT 1 -- ut310--------
    rs1475342431,2
    --48541795(+) AGTATC/TGTTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ASB8 (48541571 - 48574996 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ASB8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508673CNV Loss20534489
    esv34439CNV Gain17911159
    nsv8971CNV Gain+Loss18304495
    dgv509e1CNV Complex17122850
    dgv510e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615053    OMIM disorders: --


    Find genes that share disorders with ASB8           About GenesLikeMe


    Export disorders for ASB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASB8 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ASB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family. (PubMed id 12559969)1, 2, 9 Liu Y....Gu J. (Biochem. Biophys. Res. Commun. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    9. Array MAPPIT: high-throughput interactome analysis in mammalian cells. (PubMed id 19159283)1 Lievens S....Tavernier J. (J. Proteome Res. 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140461 HGNC: 17183 AceView: ASB8 Ensembl:ENSG00000177981 euGenes: HUgn140461
    ECgene: ASB8 H-InvDB: ASB8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ASB8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ASB8 gene:
    Search GeneIP for patents involving ASB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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