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Aliases for ASB8 Gene

Aliases for ASB8 Gene

  • Ankyrin Repeat And SOCS Box Containing 8 2 3 5
  • Ankyrin Repeat And SOCS Box-Containing 8 2
  • PP14212 3
  • ASB-8 4

External Ids for ASB8 Gene

Previous GeneCards Identifiers for ASB8 Gene

  • GC00U991142
  • GC12M048441
  • GC12M048259
  • GC12M046828
  • GC12M046827
  • GC12M048541
  • GC12M045573

Summaries for ASB8 Gene

GeneCards Summary for ASB8 Gene

ASB8 (Ankyrin Repeat And SOCS Box Containing 8) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is ANKRD1.

UniProtKB/Swiss-Prot for ASB8 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB8 Gene

Genomics for ASB8 Gene

Regulatory Elements for ASB8 Gene

Genomic Location for ASB8 Gene

Chromosome:
12
Start:
48,147,788 bp from pter
End:
48,181,213 bp from pter
Size:
33,426 bases
Orientation:
Minus strand

Genomic View for ASB8 Gene

Genes around ASB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB8 Gene

Proteins for ASB8 Gene

  • Protein details for ASB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H765-ASB8_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 8
    Protein Accession:
    Q9H765
    Secondary Accessions:
    • A8K1P2
    • Q547Q2

    Protein attributes for ASB8 Gene

    Size:
    288 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASB8 Gene

Proteomics data for ASB8 Gene at MOPED

Post-translational modifications for ASB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ASB8

No data available for DME Specific Peptides for ASB8 Gene

Domains & Families for ASB8 Gene

Gene Families for ASB8 Gene

Protein Domains for ASB8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H765

UniProtKB/Swiss-Prot:

ASB8_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 4 ANK repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with ASB8: view

Function for ASB8 Gene

Molecular function for ASB8 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes for ASB8 Gene

genes like me logo Genes that share phenotypes with ASB8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB8 Gene

Localization for ASB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASB8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB8 Gene COMPARTMENTS Subcellular localization image for ASB8 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ASB8 Gene

Pathways & Interactions for ASB8 Gene

genes like me logo Genes that share pathways with ASB8: view

UniProtKB/Swiss-Prot Q9H765-ASB8_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with ASB8: view

No data available for SIGNOR curated interactions for ASB8 Gene

Drugs & Compounds for ASB8 Gene

No Compound Related Data Available

Transcripts for ASB8 Gene

Unigene Clusters for ASB8 Gene

Ankyrin repeat and SOCS box containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - -
SP13: - - -

Relevant External Links for ASB8 Gene

GeneLoc Exon Structure for
ASB8
ECgene alternative splicing isoforms for
ASB8

Expression for ASB8 Gene

mRNA expression in normal human tissues for ASB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB8 Gene

This gene is overexpressed in Muscle - Skeletal (x8.8).

Protein differential expression in normal tissues from HIPED for ASB8 Gene

This gene is overexpressed in Spinal cord (54.0) and Retina (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB8 Gene



SOURCE GeneReport for Unigene cluster for ASB8 Gene Hs.432699

mRNA Expression by UniProt/SwissProt for ASB8 Gene

Q9H765-ASB8_HUMAN
Tissue specificity: Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas.
genes like me logo Genes that share expression patterns with ASB8: view

Protein tissue co-expression partners for ASB8 Gene

Primer Products

In Situ Assay Products

Orthologs for ASB8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ASB8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASB8 35
  • 93.17 (n)
  • 98.26 (a)
ASB8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB8 35
  • 93.06 (n)
  • 98.61 (a)
ASB8 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb8 35
  • 90.16 (n)
  • 97.22 (a)
Asb8 16
Asb8 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASB8 35
  • 99.65 (n)
  • 99.65 (a)
ASB8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb8 35
  • 90.62 (n)
  • 97.92 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ASB8 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB8 35
  • 69.14 (n)
  • 76.95 (a)
ASB8 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB8 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486931 35
  • 62.98 (n)
  • 64.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16250 35
zebrafish
(Danio rerio)
Actinopterygii asb8 35
  • 71.21 (n)
  • 79.72 (a)
wufd16d08 35
asb8 36
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2183 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 36
  • 22 (a)
OneToMany
Species with no ortholog for ASB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB8 Gene

ENSEMBL:
Gene Tree for ASB8 (if available)
TreeFam:
Gene Tree for ASB8 (if available)

Paralogs for ASB8 Gene

Paralogs for ASB8 Gene

genes like me logo Genes that share paralogs with ASB8: view

Variants for ASB8 Gene

Sequence variations from dbSNP and Humsavar for ASB8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs8804 -- 48,147,974(+) AATCA(A/G)TAACA utr-variant-3-prime
rs4760686 -- 48,153,837(+) GGTCA(A/C)AAAAC intron-variant
rs3936179 -- 48,149,801(+) GCATT(C/G)ACAGA reference, synonymous-codon
rs7301003 -- 48,156,444(+) ATGGC(A/G)GCAGA intron-variant
rs7969749 -- 48,156,972(+) GGGCA(C/T)TTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB8 Gene

Variant ID Type Subtype PubMed ID
dgv509e1 CNV Complex 17122850
nsv508673 CNV Loss 20534489
nsv8971 CNV Gain+Loss 18304495
esv34439 CNV Gain 17911159
dgv510e1 CNV Complex 17122850

Variation tolerance for ASB8 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB8 Gene

HapMap Linkage Disequilibrium report
ASB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB8 Gene

Disorders for ASB8 Gene

Relevant External Links for ASB8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB8

No disorders were found for ASB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB8 Gene

Publications for ASB8 Gene

  1. Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family. (PMID: 12559969) Liu Y. … Gu J. (Biochem. Biophys. Res. Commun. 2003) 3 4 23 67
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for ASB8 Gene

Sources for ASB8 Gene

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