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Aliases for ASB8 Gene

Aliases for ASB8 Gene

  • Ankyrin Repeat And SOCS Box Containing 8 2 3 5
  • Ankyrin Repeat And SOCS Box-Containing 8 2
  • Ankyrin Repeat And SOCS Box Protein 8 3
  • PP14212 3
  • ASB-8 4

External Ids for ASB8 Gene

Previous GeneCards Identifiers for ASB8 Gene

  • GC00U991142
  • GC12M048441
  • GC12M048259
  • GC12M046828
  • GC12M046827
  • GC12M048541
  • GC12M045573

Summaries for ASB8 Gene

GeneCards Summary for ASB8 Gene

ASB8 (Ankyrin Repeat And SOCS Box Containing 8) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ANKRD27.

UniProtKB/Swiss-Prot for ASB8 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB8 Gene

Genomics for ASB8 Gene

Regulatory Elements for ASB8 Gene

Enhancers for ASB8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G047804 2 FANTOM5 Ensembl ENCODE dbSUPER 13.7 +363.5 363465 25.6 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 ZNF143 ZNF263 SP3 TBX21 MEF2D KANSL2 CCNT1 RAPGEF3 LOC390314 ASB8 VDR SENP1 SLC48A1 ENSG00000205537 ENSG00000268069
GH12G048156 1.3 ENCODE dbSUPER 15.5 +23.8 23759 2.5 PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DEK SENP1 DDX23 CCDC184 PFKM RPL37P19 CCNT1 ZNF641 H1FNT ASB8 KANSL2
GH12G047704 1.4 FANTOM5 ENCODE 10.3 +474.9 474874 2.8 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 FOS ENSG00000257433 VDR SLC48A1 RAPGEF3 HDAC7 ASB8 ENSG00000205537 CCDC184 ENDOU
GH12G047867 1.4 Ensembl ENCODE dbSUPER 9.5 +313.2 313155 1.3 ATF1 TBL1XR1 NFIB ARNT FOS RELB IKZF2 CREM EGR2 ZNF263 HDAC7 VDR TMEM106C RAPGEF3 SLC48A1 ASB8 CCDC184 C12orf54 ENSG00000205537
GH12G048118 1.3 ENCODE dbSUPER 9.7 +61.6 61649 2.2 HDGF PKNOX1 WRNIP1 SIN3A ZNF2 ZNF121 ZNF263 SP3 JUNB TBX21 RPL37P19 ZNF641 LOC390314 DDX23 CCNT1 H1FNT ASB8 CCDC184 GC12P048122 GC12P048123
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB8 Gene

Chromosome:
12
Start:
48,147,788 bp from pter
End:
48,181,213 bp from pter
Size:
33,426 bases
Orientation:
Minus strand

Genomic View for ASB8 Gene

Genes around ASB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB8 Gene

Proteins for ASB8 Gene

  • Protein details for ASB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H765-ASB8_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 8
    Protein Accession:
    Q9H765
    Secondary Accessions:
    • A8K1P2
    • Q547Q2

    Protein attributes for ASB8 Gene

    Size:
    288 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASB8 Gene

Post-translational modifications for ASB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASB8 Gene

Domains & Families for ASB8 Gene

Gene Families for ASB8 Gene

Protein Domains for ASB8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H765

UniProtKB/Swiss-Prot:

ASB8_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB8: view

Function for ASB8 Gene

Molecular function for ASB8 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes for ASB8 Gene

genes like me logo Genes that share phenotypes with ASB8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB8 Gene

Localization for ASB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASB8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB8 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ASB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASB8: view

Pathways & Interactions for ASB8 Gene

genes like me logo Genes that share pathways with ASB8: view

UniProtKB/Swiss-Prot Q9H765-ASB8_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB8: view

No data available for SIGNOR curated interactions for ASB8 Gene

Drugs & Compounds for ASB8 Gene

No Compound Related Data Available

Transcripts for ASB8 Gene

Unigene Clusters for ASB8 Gene

Ankyrin repeat and SOCS box containing 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - -
SP13: - - -

Relevant External Links for ASB8 Gene

GeneLoc Exon Structure for
ASB8
ECgene alternative splicing isoforms for
ASB8

Expression for ASB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB8 Gene

This gene is overexpressed in Muscle - Skeletal (x8.8).

Protein differential expression in normal tissues from HIPED for ASB8 Gene

This gene is overexpressed in Spinal cord (54.0) and Retina (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB8 Gene



Protein tissue co-expression partners for ASB8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB8 Gene:

ASB8

SOURCE GeneReport for Unigene cluster for ASB8 Gene:

Hs.432699

mRNA Expression by UniProt/SwissProt for ASB8 Gene:

Q9H765-ASB8_HUMAN
Tissue specificity: Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas.

Evidence on tissue expression from TISSUES for ASB8 Gene

  • Nervous system(4.8)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ASB8: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB8 Gene

Orthologs for ASB8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ASB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB8 34 35
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia ASB8 34 35
  • 93.17 (n)
dog
(Canis familiaris)
Mammalia ASB8 34 35
  • 93.06 (n)
rat
(Rattus norvegicus)
Mammalia Asb8 34
  • 90.62 (n)
mouse
(Mus musculus)
Mammalia Asb8 34 16 35
  • 90.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ASB8 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB8 34 35
  • 69.14 (n)
lizard
(Anolis carolinensis)
Reptilia ASB8 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486931 34
  • 62.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16250 34
zebrafish
(Danio rerio)
Actinopterygii asb8 34 35
  • 71.21 (n)
wufd16d08 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2183 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 35
  • 22 (a)
OneToMany
Species where no ortholog for ASB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB8 Gene

ENSEMBL:
Gene Tree for ASB8 (if available)
TreeFam:
Gene Tree for ASB8 (if available)

Paralogs for ASB8 Gene

Paralogs for ASB8 Gene

genes like me logo Genes that share paralogs with ASB8: view

Variants for ASB8 Gene

Sequence variations from dbSNP and Humsavar for ASB8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000098926 -- 48,152,277(+) ACTTT(C/T)GCTGA intron-variant
rs1000163306 -- 48,150,419(+) CTTTC(C/T)GTACC intron-variant
rs1000552689 -- 48,152,561(+) AAACT(A/C)TAATT intron-variant
rs1000763870 -- 48,152,116(+) CATTG(C/G)ACTCC intron-variant
rs1000867697 -- 48,158,797(+) CCAGG(C/G)TGGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ASB8 Gene

Variant ID Type Subtype PubMed ID
esv2759898 CNV gain+loss 17122850
esv34439 CNV gain 17911159
esv3629429 CNV gain 21293372
nsv508673 CNV deletion 20534489
nsv8971 CNV gain+loss 18304495

Variation tolerance for ASB8 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB8 Gene

Disorders for ASB8 Gene

Relevant External Links for ASB8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB8

No disorders were found for ASB8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB8 Gene

Publications for ASB8 Gene

  1. Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family. (PMID: 12559969) Liu Y. … Gu J. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64

Products for ASB8 Gene

Sources for ASB8 Gene

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