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Aliases for ASB8 Gene

Aliases for ASB8 Gene

  • Ankyrin Repeat And SOCS Box Containing 8 2 3
  • Ankyrin Repeat And SOCS Box-Containing 8 2 3
  • ASB-8 3 4
  • Ankyrin Repeat And SOCS Box Protein 8 3
  • PP14212 3

External Ids for ASB8 Gene

Summaries for ASB8 Gene

GeneCards Summary for ASB8 Gene

ASB8 (Ankyrin Repeat And SOCS Box Containing 8) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB7.

UniProtKB/Swiss-Prot for ASB8 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB8 Gene

Genomics for ASB8 Gene

Genomic Location for ASB8 Gene

Start:
48,147,788 bp from pter
End:
48,181,213 bp from pter
Size:
33,426 bases
Orientation:
Minus strand

Genomic View for ASB8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB8 Gene

Regulatory Elements for ASB8 Gene

Proteins for ASB8 Gene

  • Protein details for ASB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H765-ASB8_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 8
    Protein Accession:
    Q9H765
    Secondary Accessions:
    • A8K1P2
    • Q547Q2

    Protein attributes for ASB8 Gene

    Size:
    288 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASB8 Gene

Proteomics data for ASB8 Gene at MOPED

Post-translational modifications for ASB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASB8 Gene

Domains for ASB8 Gene

Gene Families for ASB8 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB8 Gene

UniProtKB/Swiss-Prot:

ASB8_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.:
    • Q9H765
  • Contains 1 SOCS box domain.:
    • Q9H765
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.:
    • Q9H765
Similarity:
  • Contains 4 ANK repeats.:
    • Q9H765
genes like me logo Genes that share domains with ASB8: view

Function for ASB8 Gene

Molecular function for ASB8 Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASB8: view

miRNA for ASB8 Gene

miRTarBase miRNAs that target ASB8

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASB8 Gene

Localization for ASB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASB8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB8 Gene COMPARTMENTS Subcellular localization image for ASB8 gene
Compartment Confidence
nucleus 4
cytosol 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ASB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ASB8: view

Pathways for ASB8 Gene

genes like me logo Genes that share pathways with ASB8: view

UniProtKB/Swiss-Prot Q9H765-ASB8_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB8: view

Transcripts for ASB8 Gene

mRNA/cDNA for ASB8 Gene

Unigene Clusters for ASB8 Gene

Ankyrin repeat and SOCS box containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - - - - -
SP12: - - -
SP13: - - -

Relevant External Links for ASB8 Gene

GeneLoc Exon Structure for
ASB8
ECgene alternative splicing isoforms for
ASB8

Expression for ASB8 Gene

mRNA expression in normal human tissues for ASB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB8 Gene

This gene is overexpressed in Muscle - Skeletal (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB8 Gene

SOURCE GeneReport for Unigene cluster for ASB8 Gene Hs.432699

mRNA Expression by UniProt/SwissProt for ASB8 Gene

Q9H765-ASB8_HUMAN
Tissue specificity: Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas.
genes like me logo Genes that share expressions with ASB8: view

Orthologs for ASB8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ASB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB8 36
  • 99.65 (n)
  • 99.65 (a)
ASB8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB8 36
  • 93.17 (n)
  • 98.26 (a)
ASB8 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB8 36
  • 93.06 (n)
  • 98.61 (a)
ASB8 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb8 36
  • 90.16 (n)
  • 97.22 (a)
Asb8 16
Asb8 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB8 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb8 36
  • 90.62 (n)
  • 97.92 (a)
chicken
(Gallus gallus)
Aves ASB8 36
  • 69.14 (n)
  • 76.95 (a)
ASB8 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB8 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16250 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486931 36
  • 62.98 (n)
  • 64.64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2183 36
zebrafish
(Danio rerio)
Actinopterygii asb8 36
  • 71.21 (n)
  • 79.72 (a)
asb8 37
  • 79 (a)
OneToOne
wufd16d08 36
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 37
  • 22 (a)
OneToMany
Species with no ortholog for ASB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB8 Gene

ENSEMBL:
Gene Tree for ASB8 (if available)
TreeFam:
Gene Tree for ASB8 (if available)

Paralogs for ASB8 Gene

Paralogs for ASB8 Gene

genes like me logo Genes that share paralogs with ASB8: view

Variants for ASB8 Gene

Sequence variations from dbSNP and Humsavar for ASB8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8804 -- 48,147,974(+) AATCA(A/G)TAACA utr-variant-3-prime
rs3936179 -- 48,149,801(+) GCATT(C/G)ACAGA reference, synonymous-codon
rs4760686 -- 48,153,837(+) GGTCA(A/C)AAAAC intron-variant
rs7301003 -- 48,156,444(+) ATGGC(A/G)GCAGA intron-variant
rs7485355 -- 48,154,559(+) ACCCT(A/G)GAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB8 Gene

Variant ID Type Subtype PubMed ID
dgv509e1 CNV Complex 17122850
nsv508673 CNV Loss 20534489
nsv8971 CNV Gain+Loss 18304495
esv34439 CNV Gain 17911159
dgv510e1 CNV Complex 17122850

Relevant External Links for ASB8 Gene

HapMap Linkage Disequilibrium report
ASB8

Disorders for ASB8 Gene

No disorders were found for ASB8 Gene.

No data available for UniProtKB/Swiss-Prot for ASB8 Gene

Publications for ASB8 Gene

  1. Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family. (PMID: 12559969) Liu Y. … Gu J. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for ASB8 Gene

Sources for ASB8 Gene

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