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Aliases for ASB7 Gene

Aliases for ASB7 Gene

  • Ankyrin Repeat And SOCS Box Containing 7 2 3 5
  • ASB-7 3 4
  • Ankyrin Repeat And SOCS Box-Containing 7 2
  • Ankyrin Repeat And SOCS Box Protein 7 3

External Ids for ASB7 Gene

Previous GeneCards Identifiers for ASB7 Gene

  • GC15U990142
  • GC15P094982
  • GC15P098735
  • GC15P098878
  • GC15P098960
  • GC15P101142
  • GC15P077264

Summaries for ASB7 Gene

Entrez Gene Summary for ASB7 Gene

  • The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASB7 Gene

ASB7 (Ankyrin Repeat And SOCS Box Containing 7) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.

UniProtKB/Swiss-Prot for ASB7 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB7 Gene

Genomics for ASB7 Gene

Regulatory Elements for ASB7 Gene

Enhancers for ASB7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G101182 2 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +586.4 586380 13.8 PKNOX1 CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CHSY1 PRKXP1 LOC100419174 ASB7 TM2D3 CERS3-AS1 ENSG00000270127 PIR58100 GC15M101194
GH15G100711 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +111.3 111339 4.9 FOXA2 PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 LOC100419174 ASB7 PRKXP1 CERS3-AS1 ALDH1A3 LOC105371024 GC15M100659
GH15G101445 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +843.8 843840 2.3 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B DMAP1 YY1 SLC30A9 PRKXP1 TM2D3 LOC100419174 ASB7 ENSG00000270127 PCSK6 CHSY1 PIR54076 LOC105371028
GH15G100900 1.2 Ensembl ENCODE dbSUPER 10.4 +299.6 299564 3.3 ELF3 ATF1 JUN ETV1 MAX YY1 ZNF366 FOS FOXA1 GABPA ALDH1A3 LINS1 ASB7 GC15P100892 LRRK1
GH15G100627 1 ENCODE 11.8 +25.4 25447 0.2 HDGF ATF1 PKNOX1 SIN3A TCF12 GATA2 ELK1 FOS JUNB NCOA1 LINS1 ASB7 ALDH1A3 GC15P100639
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB7 on UCSC Golden Path with GeneCards custom track

Promoters for ASB7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000081915 -234 2601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF207 KLF13

Genomic Location for ASB7 Gene

Chromosome:
15
Start:
100,602,534 bp from pter
End:
100,651,705 bp from pter
Size:
49,172 bases
Orientation:
Plus strand

Genomic View for ASB7 Gene

Genes around ASB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB7 Gene

Proteins for ASB7 Gene

  • Protein details for ASB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H672-ASB7_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 7
    Protein Accession:
    Q9H672
    Secondary Accessions:
    • A8K1E5
    • Q6GSJ6
    • Q7Z4S3

    Protein attributes for ASB7 Gene

    Size:
    318 amino acids
    Molecular mass:
    36011 Da
    Quaternary structure:
    • Interacts with CUL5 and RNF7.

    Alternative splice isoforms for ASB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB7 Gene

Post-translational modifications for ASB7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB7 Gene

No data available for DME Specific Peptides for ASB7 Gene

Domains & Families for ASB7 Gene

Gene Families for ASB7 Gene

Suggested Antigen Peptide Sequences for ASB7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H672

UniProtKB/Swiss-Prot:

ASB7_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB7: view

Function for ASB7 Gene

Molecular function for ASB7 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ASB7: view
genes like me logo Genes that share phenotypes with ASB7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB7 Gene

Localization for ASB7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB7 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
extracellular 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ASB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASB7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB7 Gene

Pathways & Interactions for ASB7 Gene

genes like me logo Genes that share pathways with ASB7: view

UniProtKB/Swiss-Prot Q9H672-ASB7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB7: view

No data available for SIGNOR curated interactions for ASB7 Gene

Transcripts for ASB7 Gene

Unigene Clusters for ASB7 Gene

Ankyrin repeat and SOCS box containing 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB7 Gene

No ASD Table

Relevant External Links for ASB7 Gene

GeneLoc Exon Structure for
ASB7
ECgene alternative splicing isoforms for
ASB7

Expression for ASB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ASB7 Gene

This gene is overexpressed in Liver (58.4) and Urinary Bladder (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB7 Gene



Protein tissue co-expression partners for ASB7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB7 Gene:

ASB7

SOURCE GeneReport for Unigene cluster for ASB7 Gene:

Hs.31845

Evidence on tissue expression from TISSUES for ASB7 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
  • Bone(4)
genes like me logo Genes that share expression patterns with ASB7: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB7 Gene

Orthologs for ASB7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ASB7 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia ASB7 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB7 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASB7 34 35
  • 99.88 (n)
cow
(Bos Taurus)
Mammalia ASB7 34 35
  • 93.92 (n)
dog
(Canis familiaris)
Mammalia ASB7 34 35
  • 93.5 (n)
rat
(Rattus norvegicus)
Mammalia Asb7 34
  • 90.15 (n)
mouse
(Mus musculus)
Mammalia Asb7 34 16 35
  • 89.94 (n)
chicken
(Gallus gallus)
Aves ASB7 34 35
  • 88.99 (n)
lizard
(Anolis carolinensis)
Reptilia ASB7 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb7 34
  • 76.83 (n)
Str.16292 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5356 34
zebrafish
(Danio rerio)
Actinopterygii asb7 34 35
  • 76.73 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4164 34
fruit fly
(Drosophila melanogaster)
Insecta CG9121 35
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 35
  • 17 (a)
OneToMany
Species where no ortholog for ASB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB7 Gene

ENSEMBL:
Gene Tree for ASB7 (if available)
TreeFam:
Gene Tree for ASB7 (if available)

Paralogs for ASB7 Gene

Paralogs for ASB7 Gene

(3) SIMAP similar genes for ASB7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASB7: view

Variants for ASB7 Gene

Sequence variations from dbSNP and Humsavar for ASB7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000013974 -- 100,640,133(+) TGGTA(A/G)GATTT intron-variant
rs1000021242 -- 100,608,507(+) GGCTA(C/T)TGAGG intron-variant
rs1000063000 -- 100,640,348(+) CCATG(A/T)TGGTC intron-variant
rs1000087912 -- 100,609,621(+) GTTTA(C/T)ATTCA intron-variant
rs1000282202 -- 100,620,082(+) TCCTT(G/T)GGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB7 Gene

Variant ID Type Subtype PubMed ID
esv2750138 CNV deletion 23290073
esv2750139 CNV deletion 23290073
esv3306872 CNV mobile element insertion 20981092
esv3327507 CNV insertion 20981092
esv3637480 CNV gain 21293372
esv996526 CNV deletion 20482838
nsv1041172 CNV gain 25217958
nsv478319 CNV novel sequence insertion 20440878
nsv833107 CNV gain 17160897
nsv94263 CNV deletion 16902084
nsv94959 CNV deletion 16902084

Variation tolerance for ASB7 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB7 Gene

Disorders for ASB7 Gene

Relevant External Links for ASB7

Genetic Association Database (GAD)
ASB7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB7

No disorders were found for ASB7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB7 Gene

Publications for ASB7 Gene

  1. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation. (PMID: 27697924) Uematsu K. … Kamura T. (J. Cell Biol. 2016) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3 64

Products for ASB7 Gene

Sources for ASB7 Gene

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