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Aliases for ASB7 Gene

Aliases for ASB7 Gene

  • Ankyrin Repeat And SOCS Box Containing 7 2 3
  • Ankyrin Repeat And SOCS Box-Containing 7 2 3
  • ASB-7 3 4
  • Ankyrin Repeat And SOCS Box Protein 7 3

External Ids for ASB7 Gene

Summaries for ASB7 Gene

Entrez Gene Summary for ASB7 Gene

  • The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASB7 Gene

ASB7 (Ankyrin Repeat And SOCS Box Containing 7) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ANKRD42.

UniProtKB/Swiss-Prot for ASB7 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB7 Gene

Genomics for ASB7 Gene

Genomic Location for ASB7 Gene

Start:
100,602,534 bp from pter
End:
100,651,705 bp from pter
Size:
49,172 bases
Orientation:
Plus strand

Genomic View for ASB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB7 Gene

Regulatory Elements for ASB7 Gene

Proteins for ASB7 Gene

  • Protein details for ASB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H672-ASB7_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 7
    Protein Accession:
    Q9H672
    Secondary Accessions:
    • A8K1E5
    • Q6GSJ6
    • Q7Z4S3

    Protein attributes for ASB7 Gene

    Size:
    318 amino acids
    Molecular mass:
    36011 Da
    Quaternary structure:
    • Interacts with CUL5 and RNF7.

    Alternative splice isoforms for ASB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB7 Gene

Proteomics data for ASB7 Gene at MOPED

Post-translational modifications for ASB7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB7 Gene

Domains for ASB7 Gene

Gene Families for ASB7 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB7 Gene

UniProtKB/Swiss-Prot:

ASB7_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.:
    • Q9H672
  • Contains 1 SOCS box domain.:
    • Q9H672
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.:
    • Q9H672
Similarity:
  • Contains 7 ANK repeats.:
    • Q9H672
genes like me logo Genes that share domains with ASB7: view

Function for ASB7 Gene

Molecular function for ASB7 Gene

UniProtKB/Swiss-Prot Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ASB7: view

Phenotypes for ASB7 Gene

GenomeRNAi human phenotypes for ASB7:
genes like me logo Genes that share phenotypes with ASB7: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASB7 Gene

Localization for ASB7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB7 Gene COMPARTMENTS Subcellular localization image for ASB7 gene
Compartment Confidence
cytosol 3
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ASB7 Gene

Pathways for ASB7 Gene

genes like me logo Genes that share pathways with ASB7: view

UniProtKB/Swiss-Prot Q9H672-ASB7_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB7: view

Transcripts for ASB7 Gene

mRNA/cDNA for ASB7 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB7 Gene

Ankyrin repeat and SOCS box containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB7 Gene

No ASD Table

Relevant External Links for ASB7 Gene

GeneLoc Exon Structure for
ASB7
ECgene alternative splicing isoforms for
ASB7

Expression for ASB7 Gene

mRNA expression in normal human tissues for ASB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB7 Gene

SOURCE GeneReport for Unigene cluster for ASB7 Gene Hs.31845

genes like me logo Genes that share expressions with ASB7: view

Orthologs for ASB7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ASB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB7 36
  • 99.88 (n)
  • 100 (a)
ASB7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB7 36
  • 93.92 (n)
  • 100 (a)
ASB7 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB7 36
  • 93.5 (n)
  • 100 (a)
ASB7 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb7 36
  • 89.94 (n)
  • 99.37 (a)
Asb7 16
Asb7 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASB7 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB7 37
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb7 36
  • 90.15 (n)
  • 98.74 (a)
chicken
(Gallus gallus)
Aves ASB7 36
  • 88.99 (n)
  • 99.69 (a)
ASB7 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB7 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5356 36
tropical clawed frog
(Silurana tropicalis)
Amphibia asb7 36
  • 76.83 (n)
  • 96.23 (a)
Str.16292 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4164 36
zebrafish
(Danio rerio)
Actinopterygii asb7 36
  • 76.73 (n)
  • 92.45 (a)
asb7 37
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9121 37
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 37
  • 17 (a)
OneToMany
Species with no ortholog for ASB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB7 Gene

ENSEMBL:
Gene Tree for ASB7 (if available)
TreeFam:
Gene Tree for ASB7 (if available)

Paralogs for ASB7 Gene

Paralogs for ASB7 Gene

Selected SIMAP similar genes for ASB7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASB7: view

Variants for ASB7 Gene

Sequence variations from dbSNP and Humsavar for ASB7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1565748 -- 100,638,289(+) CTTGC(C/T)GTTTA intron-variant
rs1565750 -- 100,636,482(-) ACAGT(G/T)GGGGG intron-variant
rs1873956 -- 100,607,843(-) CTCCC(A/C)ACAAG intron-variant
rs1873957 -- 100,607,539(-) TACCA(C/G)AAAAA intron-variant
rs1873958 -- 100,607,521(-) ACACA(C/T)GTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB7 Gene

Variant ID Type Subtype PubMed ID
nsv833107 CNV Gain 17160897
nsv94263 CNV Loss 16902084
esv2750138 CNV Deletion 23290073
esv996526 CNV Deletion 20482838
esv2750139 CNV Deletion 23290073
nsv94959 CNV Loss 16902084
esv271148 CNV Insertion 20981092

Relevant External Links for ASB7 Gene

HapMap Linkage Disequilibrium report
ASB7

Disorders for ASB7 Gene

Relevant External Links for ASB7

Genetic Association Database (GAD)
ASB7
genes like me logo Genes that share disorders with ASB7: view

No data available for UniProtKB/Swiss-Prot for ASB7 Gene

Publications for ASB7 Gene

  1. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PMID: 15203218) Fu G.K. … Stuve L.L. (Genomics 2004) 3
  4. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. (PMID: 16159877) McCracken S. … Blencowe B.J. (J. Biol. Chem. 2005) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for ASB7 Gene

Sources for ASB7 Gene

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