ASB7 Gene
protein-coding GIFtS: 49
GCID: GC15P101142
|
|
ankyrin repeat and SOCS box containing 7(Previous name: ankyrin repeat and SOCS box-containing 7 )
| |
Aliases
for ASB7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat And SOCS Box Containing 71 2 | | Ankyrin Repeat And SOCS Box-Containing 71 2 | | ASB-72 3 | | Ankyrin Repeat And SOCS Box Protein 72 |
Export aliases for ASB7 gene to outside databasesPrevious GC identifers: GC15U990142 GC15P094982 GC15P098735 GC15P098878 GC15P098960 GC15P077264 |
Summaries
for ASB7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ASB7:
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other proteinfamilies, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge betweenspecific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin proteinligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins forpolyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding differentisoforms have been described. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ASB7_HUMAN, Q9H672Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity)
|
Genomic Views
for ASB7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010274.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASB7 gene promoter:
PPAR-alpha Max1 STAT1 POU2F1 AML1a POU2F1a STAT5A STAT1alpha c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASB7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q26.3 Ensembl cytogenetic band: 15q26.3 HGNC cytogenetic band: 15q26.3ASB7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P101142: view genomic region
(about GC identifiers)
Start:
|
101,142,739 bp from pter |
End:
|
101,191,910 bp from pter |
Size:
|
49,172 bases |
Orientation:
|
plus strand |
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Proteins
for ASB7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASB7_HUMAN, Q9H672 (See
protein sequence)Recommended Name: Ankyrin repeat and SOCS box protein 7 Size: 318 amino acids; 36011 Da
Subunit: Interacts with CUL5 and RNF7
Secondary accessions: A8K1E5 Q6GSJ6 Q7Z4S3Alternative splicing: 2 isoforms: Q9H672-1 Q9H672-2 Explore the universe of human proteins at neXtProt for ASB7: NX_Q9H672
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H672
ASB7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_078984.2 NP_937886.1
ENSEMBL proteins: ENSP00000328327 ENSP00000453626 ENSP00000339819 Reactome Protein details: Q9H672
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
ASB7 for ontologies About GeneDecksing
ASB7 Antibody Products:
Assay Products for ASB7: |
Protein
Domains /
Families
for ASB7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASB7 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H672ProtoNet protein and cluster: Q9H672 2 Blocks protein families: IPB001496 SOCS protein IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ASB7_HUMAN, Q9H672Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3ubiquitin-protein ligase complexes (By similarity)Similarity: Contains 7 ANK repeatsSimilarity: Contains 1 SOCS box domain |
Function
for ASB7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ASB7_HUMAN, Q9H672Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB7 (see all 4)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB7 |
2 GenomeRNAi human phenotypes for ASB7:
|
Pathways & Interactions
for ASB7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for ASB7
UniProtKB/Swiss-Prot: ASB7_HUMAN, Q9H672Pathway: Protein modification; protein ubiquitination
ASB7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASB7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/8 Interacting proteins for ASB7 (Q9H6722, 3 ENSP000003283274) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- | | GO:0035556 | intracellular signal transduction |
IEA | -- |
ASB7 for ontologies About GeneDecksing
|
Drugs & Compounds
for ASB7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ASB7
Search CenterWatch for drugs/clinical trials and news about ASB7
|
Transcripts
for ASB7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASB7 gene (2 alternative transcripts): NM_024708.3 NM_198243.2 Unigene Cluster for ASB7: Ankyrin repeat and SOCS box containing 7 Hs.31845 [show with all ESTs]Unigene Representative Sequence: NM_1982434 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000332783(uc002bwk.3) ENST00000558747 ENST00000343276(uc002bwj.3)
ENST00000561192
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB7 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB7 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ASB7 (NM_198243) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASB7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB7 |
Additional cDNA sequence: AK026204.1 AK057921.1 AK094123.1 AK222958.1 AK222974.1 AK289860.1 BC025252.1 BC063581.1 4 DOTS entries: DT.101955028 DT.406450 DT.121043964 DT.121043966 5 AceView cDNA sequences: CD672703 AK000966 AU117932 AU144623 CB051407
GeneLoc Exon Structure
|
Expression
for ASB7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASB7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACTCCTAG
About this image
See ASB7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASB7
SOURCE GeneReport for Unigene cluster: Hs.31845
SABiosciences Custom PCR Arrays for ASB7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASB7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB7 |
Orthologs
for ASB7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ASB7 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ASB71 |
ankyrin repeat and SOCS box containing 7 |
88.99(n)
99.69(a) |
|
415518 NM_001012770.1 NP_001012788.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ASB76 |
-- |
98(a) |
1 ↔ 1 |
GL343383.1(805429-823842) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.53562 |
Xenopus laevis transcribed sequence with moderate similarity more |
74.74(n) |
|
CA973867.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
asb71 |
ankyrin repeat and SOCS box-containing 7 |
76.73(n)
92.45(a) |
|
405798 NM_214730.1 NP_999895.1 |
ENSEMBL Gene Tree for ASB7 (if available)
TreeFam Gene Tree for ASB7 (if available) |
Paralogs
for ASB7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ASB7 gene
- ASB132 ASB122 ASB12 ASB112 ASB52 ASB92
3 SIMAP similar genes for ASB7 using alignment to 2 protein entries: ASB7_HUMAN (see all proteins):PPP1R12A PPP1R12C PSMD10
ASB7 for paralogs About GeneDecksing
|
Genomic Variants
for ASB7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASB7 (101142739 - 101191910 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ASB7
1 Indel: 11817 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB7 |
|
Disorders
/ Diseases
for ASB7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ASB7 for disorders About MalaCards
ASB7 for disorders About GeneDecksing
OMIM gene information: 615052
OMIM disorders: --
Export disorders for ASB7 gene to outside databases
|
Publications
for ASB7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASB7 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with ASB7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1, 2 Kohroki J.... Masuho Y. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. (PubMed id 16159877)1 McCracken S....Blencowe B.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (2004)
|
External Searches for ASB7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ASB7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASB7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASB7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASB7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ASB7 gene:
Search GeneIP for patents involving ASB7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASB7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ASB7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB7 | | | OriGene Protein Over-expression Lysate for ASB7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ASB7 | | OriGene 3'-UTR Clone for ASB7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ASB7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASB7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB7 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ASB7 |
| |  |  |  |  | | | | |
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 |
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 | | | ASB7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB7 |
|  |  |  | | | | Search ThermoFisher Antibodies for ASB7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB7 |
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