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Aliases for ASB6 Gene

Aliases for ASB6 Gene

  • Ankyrin Repeat And SOCS Box Containing 6 2 3
  • Ankyrin Repeat And SOCS Box-Containing 6 2
  • ASB-6 4

External Ids for ASB6 Gene

Previous GeneCards Identifiers for ASB6 Gene

  • GC09U990201
  • GC09M124043
  • GC09M125852
  • GC09M127772
  • GC09M129476
  • GC09M131436
  • GC09M132396
  • GC09M101995

Summaries for ASB6 Gene

Entrez Gene Summary for ASB6 Gene

  • The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASB6 Gene

ASB6 (Ankyrin Repeat And SOCS Box Containing 6) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for ASB6 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for ASB6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB6 Gene

Genomics for ASB6 Gene

Regulatory Elements for ASB6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ASB6 Gene

Start:
129,634,604 bp from pter
End:
129,642,217 bp from pter
Size:
7,614 bases
Orientation:
Minus strand

Genomic View for ASB6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB6 Gene

Proteins for ASB6 Gene

  • Protein details for ASB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWX5-ASB6_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 6
    Protein Accession:
    Q9NWX5
    Secondary Accessions:
    • Q5SZB7
    • Q9BV15

    Protein attributes for ASB6 Gene

    Size:
    421 amino acids
    Molecular mass:
    47136 Da
    Quaternary structure:
    • Binds APS. Identified in a complex with TCEB1 and TCEB2 (By similarity). Interacts with CUL5 and RNF7.

    Alternative splice isoforms for ASB6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB6 Gene

Proteomics data for ASB6 Gene at MOPED

Post-translational modifications for ASB6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB6 Gene

Domains for ASB6 Gene

Gene Families for ASB6 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB6 Gene

Suggested Antigen Peptide Sequences for ASB6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWX5

UniProtKB/Swiss-Prot:

ASB6_HUMAN :
  • Q9NWX5
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ASB6: view

Function for ASB6 Gene

Molecular function for ASB6 Gene

UniProtKB/Swiss-Prot Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ASB6: view

Animal Model Products

CRISPR Products

miRNA for ASB6 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASB6 Gene

Localization for ASB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASB6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB6 Gene COMPARTMENTS Subcellular localization image for ASB6 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ASB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ASB6: view

Pathways for ASB6 Gene

genes like me logo Genes that share pathways with ASB6: view

UniProtKB/Swiss-Prot Q9NWX5-ASB6_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB6: view

Transcripts for ASB6 Gene

Unigene Clusters for ASB6 Gene

Ankyrin repeat and SOCS box containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASB6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5:

Relevant External Links for ASB6 Gene

GeneLoc Exon Structure for
ASB6
ECgene alternative splicing isoforms for
ASB6

Expression for ASB6 Gene

mRNA expression in normal human tissues for ASB6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASB6 Gene

SOURCE GeneReport for Unigene cluster for ASB6 Gene Hs.125037

genes like me logo Genes that share expressions with ASB6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ASB6 Gene

Orthologs for ASB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB6 35
  • 99.29 (n)
  • 100 (a)
ASB6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB6 35
  • 89.31 (n)
  • 94.54 (a)
ASB6 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB6 35
  • 90.82 (n)
  • 95.96 (a)
ASB6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb6 35
  • 83.74 (n)
  • 90.58 (a)
Asb6 16
Asb6 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASB6 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB6 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb6 35
  • 83.97 (n)
  • 91.55 (a)
chicken
(Gallus gallus)
Aves ASB6 35
  • 70.55 (n)
  • 66.75 (a)
ASB6 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB6 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68811 35
tropical clawed frog
(Silurana tropicalis)
Amphibia asb6 35
  • 71.1 (n)
  • 73.63 (a)
zebrafish
(Danio rerio)
Actinopterygii asb6 35
  • 59.72 (n)
  • 55.83 (a)
asb6 36
  • 49 (a)
OneToOne
Dr.13589 35
Species with no ortholog for ASB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB6 Gene

ENSEMBL:
Gene Tree for ASB6 (if available)
TreeFam:
Gene Tree for ASB6 (if available)

Paralogs for ASB6 Gene

Selected SIMAP similar genes for ASB6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASB6: view

No data available for Paralogs for ASB6 Gene

Variants for ASB6 Gene

Sequence variations from dbSNP and Humsavar for ASB6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs888296 -- 129,638,810(-) AAGCC(C/T)GTCAC intron-variant
rs888297 -- 129,643,876(+) TCCCA(C/T)CTGGA upstream-variant-2KB
rs1045647 -- 129,636,921(-) ATATT(A/G)TAAGA utr-variant-3-prime
rs1133536 -- 129,639,488(+) CAAGG(A/C)CGTGT reference, missense
rs1558871 -- 129,637,574(-) TCCAG(C/T)GGCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ASB6 Gene

Variant ID Type Subtype PubMed ID
nsv893909 CNV Loss 21882294
nsv831731 CNV Gain+Loss 17160897
nsv893919 CNV Loss 21882294
nsv893923 CNV Loss 21882294
nsv469901 CNV Loss 18288195
nsv893924 CNV Loss 21882294

Relevant External Links for ASB6 Gene

HapMap Linkage Disequilibrium report
ASB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB6 Gene

Disorders for ASB6 Gene

Relevant External Links for ASB6

Genetic Association Database (GAD)
ASB6
genes like me logo Genes that share disorders with ASB6: view

No data available for UniProtKB/Swiss-Prot for ASB6 Gene

Publications for ASB6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex. (PMID: 15231829) Wilcox A. … Pillay T.S. (J. Biol. Chem. 2004) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for ASB6 Gene

Sources for ASB6 Gene

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