Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASB6 Gene

protein-coding   GIFtS: 52
GCID: GC09M132396

Ankyrin Repeat And SOCS Box Containing 6

(Previous name: ankyrin repeat and SOCS box-containing 6)
  Search for ASB6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ankyrin Repeat And SOCS Box Containing 61 2
Ankyrin Repeat And SOCS Box-Containing 61 2
Ankyrin Repeat And SOCS Box Protein 62
ASB-63

External Ids:    HGNC: 171811   Entrez Gene: 1404592   Ensembl: ENSG000001483317   OMIM: 6150515   UniProtKB: Q9NWX53   

Export aliases for ASB6 gene to outside databases

Previous GC identifers: GC09U990201 GC09M124043 GC09M125852 GC09M127772 GC09M129476 GC09M131436 GC09M101995


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASB6 Gene:
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other
protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to
the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that
comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been
identified for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for ASB6 Gene: 
ASB6 (ankyrin repeat and SOCS box containing 6) is a protein-coding gene. Among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System.

UniProtKB/Swiss-Prot: ASB6_HUMAN, Q9NWX5
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins

Gene Wiki entry for ASB6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASB6 gene promoter:
         Egr-3   Elk-1   Pax-5   SREBP-1c   C/EBPalpha   SREBP-1b   E47   CHOP-10   SREBP-1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASB6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASB6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.13   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

ASB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB6 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M132396:  view genomic region     (about GC identifiers)

Start:
132,396,883 bp from pter      End:
132,404,448 bp from pter
Size:
7,566 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASB6_HUMAN, Q9NWX5 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 6  
Size: 421 amino acids; 47136 Da
Subunit: Binds APS. Identified in a complex with TCEB1 and TCEB2 (By similarity). Interacts with CUL5 and RNF7
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q5SZB7 Q9BV15
Alternative splicing: 2 isoforms:  Q9NWX5-1   Q9NWX5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASB6: NX_Q9NWX5

Explore proteomics data for ASB6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NWX5

  • ASB6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ASB6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001189332.1  NP_060343.1  NP_821066.1  

    ENSEMBL proteins: 
     ENSP00000277459   ENSP00000277458   ENSP00000416172  
    Reactome Protein details: Q9NWX5
    Human Recombinant Protein Products for ASB6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ASB6
    OriGene Protein Over-expression Lysate for ASB6
    OriGene MassSpec for ASB6 
    OriGene Custom Protein Services for ASB6
    GenScript Custom Purified and Recombinant Proteins Services for ASB6
    Novus Biologicals ASB6 Protein
    Novus Biologicals ASB6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ASB6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    ASB6 for ontologies           About GeneDecksing



    ASB6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ASB6
    GenScript Custom Superior Antibodies Services for ASB6
    Novus Biologicals ASB6 Antibodies
    Abcam antibodies for ASB6
    Cloud-Clone Corp. Antibodies for ASB6 
    Search ThermoFisher Antibodies for ASB6
    LSBio Antibodies in human, mouse, rat for ASB6 

    Assay Products for ASB6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ASB6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ASB6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ASB6 
    Cloud-Clone Corp. CLIAs for ASB6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR001496 SOCS_C
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9NWX5

    ProtoNet protein and cluster: Q9NWX5

    2 Blocks protein domains:
    IPB001496 SOCS protein
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ASB6_HUMAN, Q9NWX5
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin-protein ligase complexes (By similarity)
    Similarity: Contains 6 ANK repeats
    Similarity: Contains 1 SOCS box domain


    ASB6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASB6_HUMAN, Q9NWX5
    Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ASB6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ASB6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ASB6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASB6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASB6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB6
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB6:
    hsa-miR-647 hsa-miR-22 hsa-miR-1184 hsa-miR-4288 hsa-miR-632 hsa-miR-346 hsa-miR-604
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ASB6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ASB6
    Sirion Biotech Customized adenovirus for overexpression of ASB6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ASB6 (see all 14)
    OriGene ORF clones in mouse, rat for ASB6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ASB6 (NM_017873)
    Sino Biological Human cDNA Clone for ASB6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB6
    Sirion Biotech Customized lentivirus for stable overexpression of ASB6 
                         Customized lentivirus expression plasmids for stable overexpression of ASB6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ASB6
    Search LifeMap BioReagents cell lines for ASB6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ASB6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for ASB6
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: ASB6_HUMAN, Q9NWX5
    Pathway: Protein modification; protein ubiquitination


    ASB6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASB6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for ASB6 (Q9NWX52, 3 ENSP000002774584) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF7Q9UBF62, 3, ENSP000002734804MINT-77971 I2D: score=2 STRING: ENSP00000273480
    CUL5Q930342, 3MINT-77972 I2D: score=2 
    SERTAD1Q9UHV23, ENSP000003506334I2D: score=1 STRING: ENSP00000350633
    SH2B2O144923, ENSP000003047014I2D: score=2 STRING: ENSP00000304701
    EWSR1Q018443I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    ASB6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASB6

    Search CenterWatch for drugs/clinical trials and news about ASB6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASB6 gene (3 alternative transcripts): 
    NM_001202403.1  NM_017873.3  NM_177999.2  

    Unigene Cluster for ASB6:

    Ankyrin repeat and SOCS box containing 6
    Hs.125037  [show with all ESTs]
    Unigene Representative Sequence: BX648923
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000277459 ENST00000277458(uc004bye.1 uc004byf.2 uc010myx.2 uc004byg.2 uc011mbt.2)
    ENST00000450050
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB6
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB6:
    hsa-miR-647 hsa-miR-22 hsa-miR-1184 hsa-miR-4288 hsa-miR-632 hsa-miR-346 hsa-miR-604
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ASB6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB6
    Clone
    Products:
         
    OriGene clones in human, mouse for ASB6 (see all 14)
    OriGene ORF clones in mouse, rat for ASB6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ASB6 (NM_017873)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB6
    Sirion Biotech Customized lentivirus for stable overexpression of ASB6 
                         Customized lentivirus expression plasmids for stable overexpression of ASB6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ASB6
    OriGene qSTAR qPCR primer pairs in human, mouse for ASB6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASB6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB6

    Additional mRNA sequence: 

    AK000555.1 AK023004.1 AK093539.1 AK225618.1 AK292807.1 AK299193.1 AL390135.1 BC001719.1 
    BC065913.1 BX648923.1 CR627462.1 

    7 DOTS entries:

    DT.92453551  DT.100751546  DT.91889663  DT.97822889  DT.75132563  DT.97841645  DT.95159180 

    24/161 AceView cDNA sequences (see all 161):

    CA424820 NM_017873 AW009753 BU153523 BM424237 BU183755 BQ057989 AA740995 
    BQ058223 AA482263 NM_177999 AK000555 BG109473 BU602539 BU618082 AA305172 
    AK093539 CB988137 BM996074 AW130456 BI518728 AI952075 BI199939 AA932568 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ASB6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:                          -                 -                     
    SP2:                          -                                       
    SP3:                          -           -     -                     
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for ASB6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASB6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCCCCACC
    ASB6 Expression
    About this image


    See ASB6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASB6

    SOURCE GeneReport for Unigene cluster: Hs.125037
        SABiosciences Custom PCR Arrays for ASB6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ASB6
    OriGene qSTAR qPCR primer pairs in human, mouse for ASB6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASB6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ASB6 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asb61 , 5 ankyrin repeat and SOCS box-containing 61, 5 83.9(n)1
    91.02(a)1
      2 (21.74 cM)5
    723231  NM_133346.21  NP_579924.11 
     308230975 
    chicken
    (Gallus gallus)
    Aves ASB61 ankyrin repeat and SOCS box containing 6 70.55(n)
    66.75(a)
      417194  NM_001030688.1  NP_001025859.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASB66
    Uncharacterized protein
    60(a)
    1 ↔ 1
    AAWZ02040296(11-6804)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688112 hypothetical protein MGC68811 79.94(n)    BC061679.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.135892 Transcribed sequence with weak similarity to protein more 73.6(n)    BI673877.1 


    ENSEMBL Gene Tree for ASB6 (if available)
    TreeFam Gene Tree for ASB6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASB6 gene
    1 SIMAP similar gene for ASB6 using alignment to 2 protein entries:     ASB6_HUMAN (see all proteins):
    DKFZp686H0429

    ASB6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/245 SNPs in ASB6 are shown (see all 245)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1114326071,2
    C,F--132398485(+) GTGAAG/ACCCCG 3 -- ut312Minor allele frequency- A:0.50NA CSA 4
    rs1911800241,2
    --132398531(+) CAGGCA/GTGATG 3 -- ut310--------
    rs1821512121,2
    --132398537(+) TGATGA/GCGGGC 3 -- ut310--------
    rs44199111,2
    C,H--132398617(+) gtgagC/Gtgaga 3 -- ut31 ese37Minor allele frequency- G:0.00NA WA CSA 17
    rs1868895421,2
    C--132398627(+) ATTGCA/GCCACT 3 -- ut310--------
    rs1133177561,2
    C,F--132398698(+) GGGCCG/AGGCAC 3 -- ut311Minor allele frequency- A:0.50NA 2
    rs1433082241,2
    C--132398700(+) GCCGGA/GCACAG 3 -- ut310--------
    rs2014782541,2
    --132398786(+) GCCTG-/ACCA  
            
    ACATG
    3 -- ut310--------
    rs1928267601,2
    C--132398796(+) CATGGC/G/TGAAAC 6 -- ut310--------
    rs1848105321,2
    --132398960(+) GACAGA/TGTGTC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ASB6 (132396883 - 132404448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ASB6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893924CNV Loss21882294
    nsv893919CNV Loss21882294
    nsv469901CNV Loss18288195
    nsv893923CNV Loss21882294
    nsv893909CNV Loss21882294
    nsv831731CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ASB6
    DNA2.0 Custom Variant and Variant Library Synthesis for ASB6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ASB6 for disorders           About MalaCards
    OMIM gene information: 615051    OMIM disorders: --


    ASB6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ASB6

    Export disorders for ASB6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASB6 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ASB6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1, 2 Kohroki J.... Masuho Y. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    5. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140459 HGNC: 17181 AceView: ASB6 Ensembl:ENSG00000148331 euGenes: HUgn140459
    ECgene: ASB6 H-InvDB: ASB6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASB6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ASB6 gene:
    Search GeneIP for patents involving ASB6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ASB6  
     OriGene qPCR primer pairs and template standards for ASB6   OriGene Protein Over-expression Lysate for ASB6  
     OriGene MassSpec something-or-other for ASB6   OriGene clones in human, mouse for ASB6  
     OriGene qSTAR qPCR primer pairs in human, mouse for ASB6   OriGene Purified Protein for ASB6  
     OriGene ORF clones in mouse, rat for ASB6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ASB6   OriGene Custom Protein Services for ASB6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASB6
     QIAGEN SeqTarget long-range PCR primers for resequencing ASB6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB6
     GenScript Custom Purified and Recombinant Proteins Services for ASB6 GenScript cDNA clones with any tag delivered in your preferred vector for ASB6
     GenScript Custom Assay Services for ASB6 GenScript Custom Superior Antibodies Services for ASB6
     GenScript Custom overexpressing Cell Line Services for ASB6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ASB6 promoter
     Search Chromatin IP Primers for ASB6
     RT2 qPCR Primer Assay in human, mouse, rat ASB6
     Search GNC Networks for ASB6
     SABiosciences Custom PCR Arrays for ASB6
     Search Tocris compounds for ASB6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ASB6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ASB6 antibodies
     ASB6 proteins
     ASB6 lysates
     Antibodies for ASB6
     See all of Abcam's Antibodies, Kits and Proteins for ASB6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ASB6
     Antibodies for ASB6
     ELISAs for ASB6
     CLIAs for ASB6
     Search LifeMap BioReagents cell lines for ASB6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ASB6
     SwitchGear Promoter luciferase reporter plasmids for ASB6
     Search ThermoFisher Antibodies for ASB6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ASB6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ASB6
    Customized:
     lentivirus for stable overexpression of ASB6
     lentivirus expression plasmids for stable overexpression of ASB6
     adenovirus for overexpression of ASB6
     LSBio Antibodies in human, mouse, rat for ASB6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ASB6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4