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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASB5 Gene

protein-coding   GIFtS: 47
GCID: GC04M177134

ankyrin repeat and SOCS box containing 5

(Previous name: ankyrin repeat and SOCS box-containing 5 )
  Search for ASB5
in
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our new
 Human Malady Compendium 
Biological research products
for ASB5    

Aliases
for ASB5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ankyrin Repeat And SOCS Box Containing 51 2
Ankyrin Repeat And SOCS Box-Containing 51 2
ASB-52 3
Ankyrin Repeat And SOCS Box Protein 52
SOCS Box Protein ASB-52

External Ids:    HGNC: 171801   Entrez Gene: 1404582   Ensembl: ENSG000001641227   OMIM: 6150505   UniProtKB: Q8WWX03   

Export aliases for ASB5 gene to outside databases

Previous GC identifers: GC04M178023 GC04M177685 GC04M177830 GC04M177509 GC04M177371 GC04M172885


Summaries
for ASB5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ASB5:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins.
They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine
signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for
degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full
length sequences are not known. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ASB5_HUMAN, Q8WWX0
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
proteins. May play a role in the initiation of arteriogenesis (By similarity)




Genomic Views
for ASB5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASB5 gene promoter:
         SRF   ISGF-3   SRF (504 AA)   FOXD3   Meis-1b   MEF-2A   POU2F1   POU2F1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ASB5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.2   Ensembl cytogenetic band:  4q34.2   HGNC cytogenetic band: 4q34.1

ASB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M177134:  view genomic region     (about GC identifiers)

Start:
 177,134,824 bp from pter      End:
 177,198,722 bp from pter
Size:
 63,899 bases      Orientation:
 minus strand

Proteins
for ASB5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ASB5_HUMAN, Q8WWX0 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 5  
Size: 329 amino acids; 36341 Da

Explore the universe of human proteins at neXtProt for ASB5: NX_Q8WWX0

ASB5 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_543150.1  
ENSEMBL proteins: 
 ENSP00000296525   ENSP00000422877   ENSP00000423232  
Reactome Protein details: Q8WWX0
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Uscn Proteins for ASB5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----


ASB5 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for ASB5

Protein Domains /
Families
for ASB5 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
ASB5 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR001496 SOCS_C
 IPR020683 Ankyrin_rpt-contain_dom
 IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q8WWX0

ProtoNet protein and cluster: Q8WWX0

2 Blocks protein families:
IPB001496 SOCS protein
IPB002110 Ankyrin repeat signature


UniProtKB/Swiss-Prot: ASB5_HUMAN, Q8WWX0
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3
ubiquitin-protein ligase complexes (By similarity)
Similarity: Contains 6 ANK repeats
Similarity: Contains 1 SOCS box domain


Function
for ASB5 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: ASB5_HUMAN, Q8WWX0
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
proteins. May play a role in the initiation of arteriogenesis (By similarity)

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB5
3 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB5:
hsa-miR-3173-3p hsa-miR-495 hsa-miR-3121-3p
SwitchGear 3'UTR luciferase reporter plasmid: ASB5 3' UTR sequence
Inhib. RNA
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OriGene shRNA RFP: ASB5
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB5

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for ASB5

Clone
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Cell Line
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In Situ Assay
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2 GenomeRNAi human phenotypes for ASB5:
 Increased cell death HMECs cel  Increased circadian period len 


Pathways & Interactions
for ASB5 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Antigen processing: Ubiquitination & Proteasome degradation
Antigen processing: Ubiquitination & Proteasome degradation1.00
Polyubiquitination of substrate0.75
Class I MHC mediated antigen processing & presentation0.83
2Immune System
Immune System1.00
Adaptive Immune System0.59

Pathway sources
See GeneCards unified pathways
Show all pathways


5        Reactome Pathways for ASB5
    Antigen processing: Ubiquitination & Proteasome degradation
Polyubiquitination of substrate
Adaptive Immune System
Class I MHC mediated antigen processing & presentation
Immune System


UniProtKB/Swiss-Prot: ASB5_HUMAN, Q8WWX0
Pathway: Protein modification; protein ubiquitination


ASB5 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASB5

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IEA--
GO:0035556intracellular signal transduction IEA--


ASB5 for ontologies           About GeneDecksing



Drugs & Compounds
for ASB5 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ASB5
Search CenterWatch for drugs/clinical trials and news about ASB5 

Transcripts
for ASB5 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for ASB5 gene: 
NM_080874.3  

Unigene Cluster for ASB5:

Ankyrin repeat and SOCS box containing 5
Hs.591712  [show with all ESTs]
Unigene Representative Sequence: BX647857
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000296525(uc003iup.2 uc003iuq.2) ENST00000512254 ENST00000511879
ENST00000510578 ENST00000505299

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB5
3 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB5:
hsa-miR-3173-3p hsa-miR-495 hsa-miR-3121-3p
SwitchGear 3'UTR luciferase reporter plasmid: ASB5 3' UTR sequence
Inhib. RNA
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Clone
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GenScript: all cDNA clones in your preferred vector: ASB5 (NM_080874)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB5 
Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB5

Additional cDNA sequence: 

AK096441.1 AK098693.1 AY057053.1 BC065710.1 BX647857.1 

4 DOTS entries:

DT.40119791  DT.40119790  DT.100022042  DT.91688153 

2 AceView cDNA sequences:

BF575270 BF694413 

GeneLoc Exon Structure


Expression
for ASB5 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ASB5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCTACCCC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

ASB5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
AdiposeInterscapular Brown Adipose DepotAdipose
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells 
NameCategory
Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
Definitive endoderm-like cells (Generation and expan...)
Definitive endoderm-like cells (A scalable, suspensi...)

See ASB5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASB5

SOURCE GeneReport for Unigene cluster: Hs.591712
    SABiosciences Custom PCR Arrays for ASB5
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB5
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB5

Orthologs
for ASB5 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for ASB5 gene from 4/16 species (see all 16)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves ASB51 ankyrin repeat and SOCS box containing 5 79.53(n)
84.8(a)		   422572  XM_001232357.1  XP_001232358.1 
lizard
(Anolis carolinensis)		 Reptilia ASB56
 --
 64(a)
 1 ↔ 1
 5(117399500-117429891)
tropical clawed frog
(Xenopus tropicalis)		 Amphibia Str.136702 Transcribed sequence with weak similarity to protein more 80.16(n)    BX736956.1 
zebrafish
(Danio rerio)		 Actinopterygii Dr.152162 Transcribed sequence with moderate similarity to protein more 71.89(n)    BM157194.1 


ENSEMBL Gene Tree for ASB5 (if available)
TreeFam Gene Tree for ASB5 (if available) 

Paralogs
for ASB5 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ASB5 gene
ASB132  ASB122  ASB12  ASB112  ASB92  ASB72  
8 SIMAP similar genes for ASB5 using alignment to 3 protein entries:     ASB5_HUMAN (see all proteins):
DKFZp313J0816    DKFZp779E2460    ASB11    ASB9    ASB13    DKFZp761E1322
MTPN    ANK1

ASB5 for paralogs           About GeneDecksing



Genomic Variants
for ASB5 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ASB5
     1 CNV: 47949
     1 Indel: 12590
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB5
DNA2.0 Custom Variant and Variant Library Synthesis for ASB5

Disorders / Diseases
for ASB5 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
ASB5 for disorders           About MalaCards

ASB5 for disorders           About GeneDecksing

OMIM gene information: 615050    OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: ASB5 (1 document)

Export disorders for ASB5 gene to outside databases

Publications
for ASB5 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ASB5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASB5)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1 Kile B.T....Hilton D.J. (2002)
  7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

External Searches for ASB5 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing ASB5 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 140458 HGNC: 17180 AceView: ASB5.1 Ensembl:ENSG00000164122 euGenes: HUgn140458
ECgene: ASB5 H-InvDB: ASB5

Other Databases showing ASB5 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing ASB5 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ASB5 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for ASB5 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ASB5 gene:
Search GeneIP for patents involving ASB5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for ASB5 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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