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ASB5 Gene(Protein Coding)

Ankyrin Repeat And SOCS Box Containing 5

GCID:
GC04M176213
GIFtS:
49
Genes Participants
UDN Logo

Aliases for ASB5 Gene

Aliases for ASB5 Gene

  • Ankyrin Repeat And SOCS Box Containing 5 2 3 5
  • ASB-5 3 4
  • Ankyrin Repeat And SOCS Box-Containing 5 2
  • Ankyrin Repeat And SOCS Box Protein 5 3
  • SOCS Box Protein ASB-5 3

External Ids for ASB5 Gene

Previous GeneCards Identifiers for ASB5 Gene

  • GC04M178023
  • GC04M177685
  • GC04M177830
  • GC04M177509
  • GC04M177371
  • GC04M177134
  • GC04M172885

Summaries for ASB5 Gene

Entrez Gene Summary for ASB5 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASB5 Gene

ASB5 (Ankyrin Repeat And SOCS Box Containing 5) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB11.

UniProtKB/Swiss-Prot for ASB5 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB5 Gene

Genomics for ASB5 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ASB5 Gene

Enhancers for ASB5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G176267 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +6.4 6360 8.1 PKNOX1 INSM2 SIN3A RAD21 ZBTB40 ZEB1 ZNF366 ZSCAN5C RCOR1 FOS ASB5 SPCS3 GC04M176057
GH04G176237 1.2 Ensembl ENCODE dbSUPER 17.1 +39.4 39399 2.3 KLF1 FOXA2 RFX1 GFI1B OVOL3 FEZF1 ZNF384 ZNF843 PRDM6 ZNF512 ASB5 GPM6A GC04M176057
GH04G176258 1 Ensembl ENCODE dbSUPER 15 +17.2 17176 3.0 JUND NRF1 SIN3A CEBPB FOS ASB5 GC04M176057
GH04G176250 0.5 dbSUPER 25.7 +26.9 26940 1.3 NFIC ZNF316 KDM1A MAFK ASB5 GC04M176057
GH04G176251 0.5 dbSUPER 25.7 +26.9 26947 1.3 NFIC ZNF316 KDM1A MAFK ASB5 GC04M176057
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ASB5 gene promoter:

Genomic Location for ASB5 Gene

Chromosome:
4
Start:
176,213,673 bp from pter
End:
176,277,571 bp from pter
Size:
63,899 bases
Orientation:
Minus strand

Genomic View for ASB5 Gene

Genes around ASB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ASB5 Gene

Proteins for ASB5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ASB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWX0-ASB5_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 5
    Protein Accession:
    Q8WWX0
    Secondary Accessions:
    • Q8N7B5

    Protein attributes for ASB5 Gene

    Size:
    329 amino acids
    Molecular mass:
    36341 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ASB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB5 Gene

Post-translational modifications for ASB5 Gene

No Post-translational modifications

Other Protein References for ASB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB5 Gene

Domains & Families for ASB5 Gene

Gene Families for ASB5 Gene

HGNC:

Protein Domains for ASB5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ASB5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWX0

UniProtKB/Swiss-Prot:

ASB5_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB5: view

Function for ASB5 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ASB5 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the initiation of arteriogenesis (By similarity).
genes like me logo Genes that share phenotypes with ASB5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB5 Gene

Localization for ASB5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB5 gene
Compartment Confidence
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ASB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASB5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB5 Gene

Pathways & Interactions for ASB5 Gene

genes like me logo Genes that share pathways with ASB5: view

UniProtKB/Swiss-Prot Q8WWX0-ASB5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB5: view

No data available for SIGNOR curated interactions for ASB5 Gene

Drugs & Compounds for ASB5 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for ASB5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ASB5 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB5 Gene

Ankyrin repeat and SOCS box containing 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB5 Gene

No ASD Table

Relevant External Links for ASB5 Gene

GeneLoc Exon Structure for
ASB5
ECgene alternative splicing isoforms for
ASB5

Expression for ASB5 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB5 Gene

mRNA expression in normal human tissues for ASB5 Gene
mRNA expression by BioGPS for ASB5 GenemRNA expression by GTEx for ASB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB5 Gene

This gene is overexpressed in Muscle - Skeletal (x35.4).

NURSA nuclear receptor signaling pathways regulating expression of ASB5 Gene:

ASB5

SOURCE GeneReport for Unigene cluster for ASB5 Gene:

Hs.591712

Evidence on tissue expression from TISSUES for ASB5 Gene

  • Muscle(4.6)
genes like me logo Genes that share expression patterns with ASB5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB5 Gene

Orthologs for ASB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ASB5 34 35
  • 99.8 (n)
oppossum
(Monodelphis domestica)
 Mammalia ASB5 35
  • 88 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Asb5 34 16 35
  • 87.44 (n)
cow
(Bos Taurus)
 Mammalia ASB5 34 35
  • 87.23 (n)
dog
(Canis familiaris)
 Mammalia ASB5 34 35
  • 87.23 (n)
rat
(Rattus norvegicus)
 Mammalia Asb5 34
  • 86.31 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia ASB5 35
  • 72 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ASB5 34 35
  • 79.53 (n)
lizard
(Anolis carolinensis)
 Reptilia ASB5 35
  • 64 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.13670 34
zebrafish
(Danio rerio)
 Actinopterygii asb5b 34 35
  • 66.26 (n)
ASB5 (3 of 3) 35
  • 64 (a)
 OneToMany
spata4 35
  • 64 (a)
 OneToMany
Dr.15216 34
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.4234 35
  • 35 (a)
 OneToMany
Species where no ortholog for ASB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB5 Gene

ENSEMBL:
Gene Tree for ASB5 (if available)
TreeFam:
Gene Tree for ASB5 (if available)

Paralogs for ASB5 Gene

Paralogs for ASB5 Gene

(8) SIMAP similar genes for ASB5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ASB5: view

Variants for ASB5 Gene

Sequence variations from dbSNP and Humsavar for ASB5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000008694 -- 176,217,175(+) ACATA(C/T)ACATA intron-variant
rs1000041021 -- 176,245,902(+) GTGGG(G/T)TGGGG intron-variant
rs1000062312 -- 176,220,018(+) GATAG(C/T)TGATG intron-variant
rs1000088838 -- 176,252,317(+) CATTA(A/G)CACTT intron-variant
rs1000119398 -- 176,240,482(+) AAGAA(A/G)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB5 Gene

Variant ID Type Subtype PubMed ID
esv1348309 CNV insertion 17803354
esv2728772 CNV deletion 23290073
esv34137 CNV loss 18971310
esv3603274 CNV gain 21293372
nsv1017524 CNV gain 25217958
nsv1020155 CNV gain+loss 25217958
nsv1020249 CNV loss 25217958
nsv1074773 CNV deletion 25765185
nsv1119522 CNV insertion 24896259
nsv293663 CNV deletion 16902084
nsv4612 CNV deletion 18451855
nsv596262 CNV gain 21841781
nsv596263 CNV loss 21841781

Variation tolerance for ASB5 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB5 Gene

Disorders for ASB5 Gene

Relevant External Links for ASB5

Genetic Association Database (GAD)
ASB5
Human Genome Epidemiology (HuGE) Navigator
ASB5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB5

No disorders were found for ASB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB5 Gene

Publications for ASB5 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for ASB5 Gene

Sources for ASB5 Gene

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