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ASB5 Gene

protein-coding   GIFtS: 48
GCID: GC04M177134

Ankyrin Repeat And SOCS Box Containing 5

(Previous name: ankyrin repeat and SOCS box-containing 5)
  Search for ASB5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And SOCS Box Containing 51 2
Ankyrin Repeat And SOCS Box-Containing 51 2
ASB-52 3
Ankyrin Repeat And SOCS Box Protein 52
SOCS Box Protein ASB-52

External Ids:    HGNC: 171801   Entrez Gene: 1404582   Ensembl: ENSG000001641227   OMIM: 6150505   UniProtKB: Q8WWX03   

Export aliases for ASB5 gene to outside databases

Previous GC identifers: GC04M178023 GC04M177685 GC04M177830 GC04M177509 GC04M177371 GC04M172885


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASB5 Gene:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of
proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of
cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly
targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this
gene but their full length sequences are not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for ASB5 Gene:
ASB5 (ankyrin repeat and SOCS box containing 5) is a protein-coding gene. An important paralog of this gene is ASB13.

UniProtKB/Swiss-Prot: ASB5_HUMAN, Q8WWX0
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins. May play a role in the initiation of arteriogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASB5 gene promoter:
         SRF   ISGF-3   SRF (504 AA)   FOXD3   Meis-1b   MEF-2A   POU2F1   POU2F1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASB5 promoter sequence
   Search Chromatin IP Primers for ASB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q34.2   Ensembl cytogenetic band:  4q34.2   HGNC cytogenetic band: 4q34.1

ASB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB5 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M177134:  view genomic region     (about GC identifiers)

Start:
177,134,824 bp from pter      End:
177,198,722 bp from pter
Size:
63,899 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ASB5_HUMAN, Q8WWX0 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 5  
Size: 329 amino acids; 36341 Da

Explore the universe of human proteins at neXtProt for ASB5: NX_Q8WWX0

Explore proteomics data for ASB5 at MOPED


See ASB5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_543150.1  
ENSEMBL proteins: 
 ENSP00000296525   ENSP00000422877   ENSP00000423232  
Reactome Protein details: Q8WWX0

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing

3 InterPro protein domains:
 IPR002110 Ankyrin_rpt
 IPR001496 SOCS_C
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q8WWX0

ProtoNet protein and cluster: Q8WWX0

2 Blocks protein domains:
IPB001496 SOCS protein
IPB002110 Ankyrin repeat signature


UniProtKB/Swiss-Prot: ASB5_HUMAN, Q8WWX0
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
E3 ubiquitin-protein ligase complexes (By similarity)
Similarity: Contains 6 ANK repeats
Similarity: Contains 1 SOCS box domain


ASB5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ASB5_HUMAN, Q8WWX0
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins. May play a role in the initiation of arteriogenesis (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
ASB5 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for ASB5:
 Increased cell death HMECs cel  Increased circadian period len 

Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidASB5 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
cytoskeleton1
endoplasmic reticulum1
extracellular1
mitochondrion1
peroxisome1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ASB5 About                                                                                                See pathways by source

SuperPathContained pathways About
1Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ASB5
    Antigen processing: Ubiquitination & Proteasome degradation


UniProtKB/Swiss-Prot: ASB5_HUMAN, Q8WWX0
Pathway: Protein modification; protein ubiquitination


ASB5 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASB5
Interactions:

    Search GeneGlobe Interaction Network for ASB5

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IEA--
GO:0035556intracellular signal transduction IEA--

ASB5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ASB5



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ASB5 gene: 
NM_080874.3  

Unigene Cluster for ASB5:

Ankyrin repeat and SOCS box containing 5
Hs.591712  [show with all ESTs]
Unigene Representative Sequence: BX647857
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000296525(uc003iup.2 uc003iuq.2) ENST00000512254 ENST00000511879
ENST00000510578 ENST00000505299
miRNA
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3 qRT-PCR Assays for microRNAs that regulate ASB5:
hsa-miR-3173-3p hsa-miR-495 hsa-miR-3121-3p
SwitchGear 3'UTR luciferase reporter plasmidASB5 3' UTR sequence
Inhib. RNA
Products:
     
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat ASB5

Additional mRNA sequence: 

AK096441.1 AK098693.1 AY057053.1 BC065710.1 BX647857.1 

4 DOTS entries:

DT.40119791  DT.40119790  DT.100022042  DT.91688153 

2 AceView cDNA sequences:

BF694413 BF575270 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ASB5 expression in normal human tissues (normalized intensities)      ASB5 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGCTACCCC
ASB5 Expression
About this image


ASB5 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Heart (Cardiovascular System)
         Mature Cardiac Fibroblasts Myocardium
 
 Fibroblasts
         Mature Cardiac Fibroblasts Myocardium
 
 NULL (Uncategorized)
         Definitive endoderm-like cells
ASB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ASB5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591712
    Custom PCR Arrays for ASB5
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ASB5 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Asb51 , 5 ankyrin repeat and SOCs box-containing 51, 5 87.44(n)1
93.62(a)1
  8 (29.27 cM)5
762941  NM_029569.31  NP_083845.11 
 545503315 
chicken
(Gallus gallus)
Aves ASB51 ankyrin repeat and SOCS box containing 5 79.53(n)
84.8(a)
  422572  XM_004941082.1  XP_004941139.1 
lizard
(Anolis carolinensis)
Reptilia ASB56
ankyrin repeat and SOCS box containing 5
64(a)
1 ↔ 1
5(117399402-117429891)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.136702 Transcribed sequence with weak similarity to protein more 80.16(n)    BX736956.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.152162 Transcribed sequence with moderate similarity to protein more 71.89(n)    BM157194.1 


ENSEMBL Gene Tree for ASB5 (if available)
TreeFam Gene Tree for ASB5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ASB5 gene
ASB132  ASB122  ASB12  ASB112  ASB92  
8 SIMAP similar genes for ASB5 using alignment to 3 protein entries:     ASB5_HUMAN (see all proteins):
DKFZp313J0816    DKFZp779E2460    ASB11    ASB9    ASB13    DKFZp761E1322
MTPN    ANK1

ASB5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ASB5 (see all 1341)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs170626231,2
C,F,H--177134340(+) CTACTC/GTGAAG 1 -- ds500118Minor allele frequency- G:0.10NA NS EA WA CSA 1228
rs1908525291,2
--177134379(+) TTACTA/TTCTCA 1 -- ds50010--------
rs1456891211,2
--177134450(+) AAAAAA/CATTGT 1 -- ds50010--------
rs131062911,2
C,F--177134588(+) ATGTAT/CATATG 1 -- ds50014Minor allele frequency- C:0.24NA 126
rs125133041,2
C,F,H--177134591(+) TATATA/GTGTAT 1 -- ds50013Minor allele frequency- G:0.10NA EA 242
rs1831720171,2
--177134664(+) TCTTGG/TATTAG 1 -- ds50010--------
rs1878846071,2
--177134759(+) AAAATC/TAGTGC 1 -- ds50010--------
rs1929763191,2
--177134890(+) TTAGAA/GCACTA 1 -- ut310--------
rs1842945551,2
--177135273(+) TCTCAA/GCAAAC 1 -- ut310--------
rs1875256721,2
--177135439(+) ATATTC/TACTTT 1 -- ut310--------

HapMap Linkage Disequilibrium report for ASB5 (177134824 - 177198722 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for ASB5:    About this table    
Variant IDTypeSubtypePubMed ID
esv2728772CNV Deletion23290073
esv1348309CNV Insertion17803354
esv34137CNV Loss18971310
nsv4612CNV Loss18451855
nsv293663CNV Loss16902084

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for ASB5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 615050    OMIM disorders: --


ASB5 for disorders           About GeneDecksing

Genetic Association Database (GAD): ASB5
Human Genome Epidemiology (HuGE) Navigator: ASB5 (1 document)

Export disorders for ASB5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ASB5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ASB5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
  7. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 140458 HGNC: 17180 AceView: ASB5.1 Ensembl:ENSG00000164122 euGenes: HUgn140458
ECgene: ASB5 H-InvDB: ASB5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ASB5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ASB5 gene:
Search GeneIP for patents involving ASB5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASB5
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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