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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASB4 Gene

protein-coding   GIFtS: 50
GCID: GC07P095107

Ankyrin Repeat And SOCS Box Containing 4

(Previous name: ankyrin repeat and SOCS box-containing 4)
  Search for ASB4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ankyrin Repeat And SOCS Box Containing 41 2
Ankyrin Repeat And SOCS Box-Containing 41 2
ASB-42 3
Ankyrin Repeat And SOCS Box Protein 42

External Ids:    HGNC: 160091   Entrez Gene: 516662   Ensembl: ENSG000000059817   OMIM: 6057615   UniProtKB: Q9Y5743   

Export aliases for ASB4 gene to outside databases

Previous GC identifers: GC07P093650 GC07P094713 GC07P094727 GC07P094759 GC07P094953 GC07P089722


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASB4 Gene:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of
proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of
cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly
targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this
gene but some of the full length sequences are not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for ASB4 Gene: 
ASB4 (ankyrin repeat and SOCS box containing 4) is a protein-coding gene. Among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is ASB16.

UniProtKB/Swiss-Prot: ASB4_HUMAN, Q9Y574
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASB4 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   Elk-1   oct-B2   oct-B3   POU2F2   POU2F1   POU2F1a   POU2F2B   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ASB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21-q22

ASB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P095107:  view genomic region     (about GC identifiers)

Start:
95,107,756 bp from pter      End:
95,169,544 bp from pter
Size:
61,789 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 94,444,224-94,498,555     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASB4_HUMAN, Q9Y574 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 4  
Size: 426 amino acids; 48195 Da
Subunit: Interacts with HIF1AN. Component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein
ligase complex formed of CUL2 or CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and ASB4
Secondary accessions: A4D1H6 O14586 Q14D68 Q8TBT2
Alternative splicing: 2 isoforms:  Q9Y574-1   Q9Y574-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASB4: NX_Q9Y574

Explore proteomics data for ASB4 at MOPED 

Post-translational modifications:

  • UniProtKB: Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4
    in promoting vascular differentiation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y574

  • ASB4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ASB4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_057200.1  NP_665879.1  

    ENSEMBL proteins: 
     ENSP00000397070   ENSP00000321388  
    Reactome Protein details: Q9Y574
    Human Recombinant Protein Products for ASB4: 
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    Novus Biologicals ASB4 Protein
    Novus Biologicals ASB4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ASB4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031462Cul2-RING ubiquitin ligase complex IDA17636018
    GO:0031466Cul5-RING ubiquitin ligase complex IDA17636018

    ASB4 for ontologies           About GeneDecksing



    ASB4 Antibody Products: 
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    Assay Products for ASB4: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR001496 SOCS_C
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9Y574

    ProtoNet protein and cluster: Q9Y574

    2 Blocks protein domains:
    IPB001496 SOCS protein
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ASB4_HUMAN, Q9Y574
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin-protein ligase complexes (By similarity)
    Similarity: Contains 6 ANK repeats
    Similarity: Contains 1 SOCS box domain


    ASB4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASB4_HUMAN, Q9Y574
    Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism
    (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0019899enzyme binding ----
    GO:0031625ubiquitin protein ligase binding IEA--
         
    ASB4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ASB4:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ASB4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ASB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASB4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASB4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB4
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB4 (see all 37):
    hsa-miR-2052 hsa-miR-3130-5p hsa-miR-19b-2* hsa-miR-605 hsa-miR-624* hsa-miR-30d hsa-miR-374a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidASB4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): ASB4 (NM_016116)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB4
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                         Customized lentivirus expression plasmids for stable overexpression of ASB4 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ASB4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for ASB4
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: ASB4_HUMAN, Q9Y574
    Pathway: Protein modification; protein ubiquitination


    ASB4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for ASB4 (Q9Y5743 ENSP000003213884) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1ANQ9NWT63, ENSP000002991634I2D: score=2 STRING: ENSP00000299163
    CUL2Q136173, ENSP000003638804I2D: score=1 STRING: ENSP00000363880
    TCEB2Q153703, ENSP000002623064I2D: score=1 STRING: ENSP00000262306
    RIT1Q929633, ENSP000003573064I2D: score=1 STRING: ENSP00000357306
    CUL5Q930343I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035556intracellular signal transduction IEA--
    GO:0051865protein autoubiquitination IEA--
    GO:2001214positive regulation of vasculogenesis ISS--

    ASB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASB4

    Search CenterWatch for drugs/clinical trials and news about ASB4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ASB4 gene (2 alternative transcripts): 
    NM_016116.2  NM_145872.2  

    Unigene Clusters for ASB4:

    Ankyrin repeat and SOCS box containing 4
    Hs.602765  [show with all ESTs], Hs.737518
    Unigene Representative Sequences: NM_016116, AK096449
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257621 ENST00000428113(uc003unx.3) ENST00000325885(uc011kij.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB4
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB4 (see all 37):
    hsa-miR-2052 hsa-miR-3130-5p hsa-miR-19b-2* hsa-miR-605 hsa-miR-624* hsa-miR-30d hsa-miR-374a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidASB4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ASB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB4
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    OriGene clones in human, mouse for ASB4 (see all 11)
    OriGene ORF clones in mouse, rat for ASB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ASB4 (NM_016116)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB4
    Sirion Biotech Customized lentivirus for stable overexpression of ASB4 
                         Customized lentivirus expression plasmids for stable overexpression of ASB4 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ASB4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB4

    Additional mRNA sequence: AK096449.1 

    3 DOTS entries:

    DT.40128784  DT.40126847  DT.70102555 

    24/44 AceView cDNA sequences (see all 44):

    AA939011 BQ271627 AI871650 NM_016116 BQ632379 AF156779 BX097790 BX509319 
    BE220587 AI457276 BC025024 AI681644 NM_145872 AA927436 AI791680 AV710738 
    BF793517 BX103122 BX499925 AW341334 BG104496 BF792453 BX507301 N44184 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASB4 expression in normal human tissues (normalized intensities)      ASB4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ASB4 Expression
    About this image


    ASB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Thalamus
             Substantia Nigra   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Floor Plate Cells Spinal Floor Plate
             Telencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             limb/hindlimb   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Mandibular Process
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube

    See ASB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASB4

    SOURCE GeneReport for Unigene clusters: Hs.602765 Hs.737518
        SABiosciences Custom PCR Arrays for ASB4
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ASB4 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asb41 , 5 ankyrin repeat and SOCS box-containing 41, 5 85.68(n)1
    92.49(a)1
      6 (1.99 cM)5
    652551  NM_023048.51  NP_075535.11 
     53833865 
    chicken
    (Gallus gallus)
    Aves ASB41 ankyrin repeat and SOCS box containing 4 73.83(n)
    75.18(a)
      420569  XM_418670.2  XP_418670.2 
    lizard
    (Anolis carolinensis)
    Reptilia ASB46
    ankyrin repeat and SOCS box containing 4
    69(a)
    1 ↔ 1
    6(22537229-22550629)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.124722 Transcribed sequence with weak similarity to protein more 73.28(n)    BX712709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii asb41 ankyrin repeat and SOCS box-containing 4 62.31(n)
    60.05(a)
      550321  NM_001017628.1  NP_001017628.1 


    ENSEMBL Gene Tree for ASB4 (if available)
    TreeFam Gene Tree for ASB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASB4 gene
    ASB162  ASB182  ASB102  
    3 SIMAP similar genes for ASB4 using alignment to 1 protein entry:     ASB4_HUMAN:
    ASB18    ASB16    ASB10

    ASB4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1118 SNPs in ASB4 are shown (see all 1118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852236171,2
    --95113251(+) TTTCCA/GTATAT 2 -- us2k10--------
    rs119788381,2
    C,F,H--95113312(+) caaaaA/Gttgta 2 -- us2k15Minor allele frequency- G:0.04NS EA WA 534
    rs114313881,2
    C--95113339(+) AAAAA-/A/AAA 
            
    TTGTC
    4 -- us2k1 cds10--------
    rs737113141,2
    C,F--95113364(+) GTCAGG/ACATAG 2 -- us2k13Minor allele frequency- A:0.07WA NA 240
    rs624676741,2
    C--95113386(+) TGTAAA/TCCCAG 2 -- us2k10--------
    rs37577041,2
    C,F--95113420(-) TTAAGC/AGAACC 2 -- us2k12Minor allele frequency- A:0.05NA EA 240
    rs1900715701,2
    --95113433(+) TTAGGA/TGTCGG 2 -- us2k10--------
    rs1411439351,2
    --95113437(+) AGTCG-/CAGAT 
            
    GAGAT
    2 -- us2k10--------
    rs2020064821,2
    --95113438(+) GTCGG-/ATCAGATC 2 -- cds10--------
    rs1498091421,2
    --95113585(+) GTTGCA/GGTGAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ASB4 (95107756 - 95169544 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ASB4: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ASB4 for disorders           About MalaCards
    OMIM gene information: 605761    OMIM disorders: --


    ASB4 for disorders           About GeneDecksing


    Export disorders for ASB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASB4 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ASB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PubMed id 11111040)1, 2, 9 Kile B.T....Alexander W.S. (2000)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. (PubMed id 17276034)1, 9 Li J.Y....Mulholland M.W. (2007)
    5. ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. (PubMed id 17636018)1, 9 Ferguson J.E....Patterson C. (2007)
    6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    7. Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits. (PubMed id 15929745)1 Li J.Y....Gantz I. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51666 HGNC: 16009 AceView: ASB4 Ensembl:ENSG00000005981 euGenes: HUgn51666
    ECgene: ASB4 H-InvDB: ASB4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ASB4 gene:
    Search GeneIP for patents involving ASB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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