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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASB4 Gene

protein-coding   GIFtS: 50
GCID: GC07P095107

ankyrin repeat and SOCS box containing 4

(Previous name: ankyrin repeat and SOCS box-containing 4 )
  Search for ASB4
in
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Biological research products
for ASB4    

Aliases
for ASB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ankyrin Repeat And SOCS Box Containing 41 2
ASB-41 2 3
Ankyrin Repeat And SOCS Box-Containing 41 2
Ankyrin Repeat And SOCS Box Protein 42

External Ids:    HGNC: 160091   Entrez Gene: 516662   Ensembl: ENSG000000059817   OMIM: 6057615   UniProtKB: Q9Y5743   

Export aliases for ASB4 gene to outside databases

Previous GC identifers: GC07P093650 GC07P094713 GC07P094727 GC07P094759 GC07P094953 GC07P089722


Summaries
for ASB4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ASB4:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins.
They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine
signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for
degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full
length sequences are not known. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ASB4_HUMAN, Q9Y574
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By
similarity)




Genomic Views
for ASB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASB4 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   Elk-1   oct-B2   oct-B3   POU2F2   POU2F1   POU2F1a   POU2F2B   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ASB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21-q22   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21-q22

ASB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P095107:  view genomic region     (about GC identifiers)

Start:
 95,107,756 bp from pter      End:
 95,169,544 bp from pter
Size:
 61,789 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 94,444,295-94,496,085     

Proteins
for ASB4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ASB4_HUMAN, Q9Y574 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 4  
Size: 426 amino acids; 48195 Da
Subunit: Interacts with HIF1AN. Component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase
complex formed of CUL2 or CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and ASB4
Secondary accessions: A4D1H6 O14586 Q14D68 Q8TBT2
Alternative splicing: 2 isoforms:  Q9Y574-1   Q9Y574-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASB4: NX_Q9Y574

Post-translational modifications:

  • Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in
    • promoting vascular differentiation (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y574

    • ASB4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_057200.1  NP_665879.1  

    ENSEMBL proteins: 
     ENSP00000321388   ENSP00000397070  
    Reactome Protein details: Q9Y574
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): ASB4
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    Novus Biologicals ASB4 Protein
    Novus Biologicals ASB4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ASB4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031462Cul2-RING ubiquitin ligase complex IDA17636018
    GO:0031466Cul5-RING ubiquitin ligase complex IDA17636018


    ASB4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ASB4

    Protein Domains /
    Families
    for ASB4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ASB4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001496 SOCS_C
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q9Y574

    ProtoNet protein and cluster: Q9Y574

    2 Blocks protein families:
    IPB001496 SOCS protein
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ASB4_HUMAN, Q9Y574
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3
    ubiquitin-protein ligase complexes (By similarity)
    Similarity: Contains 6 ANK repeats
    Similarity: Contains 1 SOCS box domain


    Function
    for ASB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ASB4_HUMAN, Q9Y574
    Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
    proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By
    similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB4
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB4 (see all 37):
    hsa-miR-2052 hsa-miR-3130-5p hsa-miR-19b-2* hsa-miR-605 hsa-miR-624* hsa-miR-30d hsa-miR-374a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: ASB4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB4 (see all 7)
    OriGene shRNA RFP: ASB4
    OriGene siRNA: ASB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ASB4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB4 (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 2): ASB4 (NM_016116)
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0019899enzyme binding ----
    GO:0031625ubiquitin protein ligase binding IEA--


    ASB4 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ASB4:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for ASB4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for ASB4
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: ASB4_HUMAN, Q9Y574
    Pathway: Protein modification; protein ubiquitination


    ASB4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for ASB4 (Q9Y5743 ENSP000003213884) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1ANQ9NWT63, ENSP000002991634I2D: score=2 STRING: ENSP00000299163
    CUL2Q136173, ENSP000003638804I2D: score=1 STRING: ENSP00000363880
    TCEB2Q153703, ENSP000002623064I2D: score=1 STRING: ENSP00000262306
    RIT1Q929633, ENSP000003573064I2D: score=1 STRING: ENSP00000357306
    CUL5Q930343I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination ----
    GO:0035556intracellular signal transduction IEA--
    GO:0051865protein autoubiquitination IEA--
    GO:2001214positive regulation of vasculogenesis ISS--


    ASB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ASB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASB4
    Search CenterWatch for drugs/clinical trials and news about ASB4 

    Transcripts
    for ASB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ASB4 gene (2 alternative transcripts): 
    NM_016116.2  NM_145872.2  

    Unigene Clusters for ASB4:

    Ankyrin repeat and SOCS box containing 4
    Hs.602765  [show with all ESTs], Hs.737518
    Unigene Representative Sequences: NM_016116, AK096449
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257621 ENST00000325885(uc011kij.2) ENST00000428113(uc003unx.3)


    miRNA
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    hsa-miR-2052 hsa-miR-3130-5p hsa-miR-19b-2* hsa-miR-605 hsa-miR-624* hsa-miR-30d hsa-miR-374a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: ASB4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB4 (see all 7)
    OriGene shRNA RFP: ASB4
    OriGene siRNA: ASB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB4
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB4

    Additional cDNA sequence: AK096449.1 

    3 DOTS entries:

    DT.40128784  DT.40126847  DT.70102555 

    24/44 AceView cDNA sequences (see all 44):

    AA939011 NM_016116 BX509319 BE220587 BC025024 AI681644 BQ632379 AI457276 
    NM_145872 BQ271627 AI791680 BX097790 AI871650 AF156779 AA927436 AK096449 
    BF793517 BQ271941 BX507301 AI268368 AW341334 N44184 AI733344 BG675432 

    GeneLoc Exon Structure


    Expression
    for ASB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ASB4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    KidneyRenal VesicleKidney
    SomiteLumbar Vertebral BodySomite
    Spinal CordSpinal Floor PlateSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite

    See ASB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASB4

    SOURCE GeneReport for Unigene clusters: Hs.602765 Hs.737518
        SABiosciences Custom PCR Arrays for ASB4
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    In Situ
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    Orthologs
    for ASB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ASB4 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ASB41 ankyrin repeat and SOCS box containing 4 73.83(n)
    75.18(a)    		   420569  XM_418670.2  XP_418670.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ASB46
    		 --
    		 68(a)
    		 1 ↔ 1
    		 6(22537426-22547013)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.124722 Transcribed sequence with weak similarity to protein more 73.28(n)    BX712709.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii asb41 ankyrin repeat and SOCS box-containing 4 62.31(n)
    60.05(a)    		   550321  NM_001017628.1  NP_001017628.1 


    ENSEMBL Gene Tree for ASB4 (if available)
    TreeFam Gene Tree for ASB4 (if available) 

    Paralogs
    for ASB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASB4 gene
    ASB182  ASB162  ASB102  
    3 SIMAP similar genes for ASB4 using alignment to 1 protein entry:     ASB4_HUMAN:
    ASB18    ASB16    ASB10

    ASB4 for paralogs           About GeneDecksing



    Genomic Variants
    for ASB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/974 NCBI SNPs in ASB4 are shown (see all 974)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs64654681,2
    		C,F,A,H,--94498526(+) TTAGAG/TAACTT 1 -- us2k117Minor allele frequency- T:0.14NS EA NA WA 2208
    rs1852236171,2
    		--95113251(+) TTTCCA/GTATAT 2 -- us2k10--------
    rs119788381,2
    		C,F,H,--95113312(+) caaaaA/Gttgta 2 -- us2k15Minor allele frequency- G:0.04NS EA WA 534
    rs737113141,2
    		C,--95113364(+) GTCAGG/ACATAG 2 -- us2k13Minor allele frequency- A:0.07WA NA 240
    rs624676741,2
    		C,--95113386(+) TGTAAA/TCCCAG 2 -- us2k10--------
    rs37577041,2
    		C,F,--95113420(-) TTAAGC/AGAACC 2 -- us2k12Minor allele frequency- A:0.05NA EA 240
    rs1900715701,2
    		--95113433(+) TTAGGA/TGTCGG 2 -- us2k10--------
    rs1411439351,2
    		--95113437(+) AGTCG-/CAGAT 
                GAGAT     		2 -- us2k10--------
    rs2020064821,2
    		--95113438(+) GTCGG-/ATCAGATC 2 -- us2k10--------
    rs1498091421,2
    		--95113585(+) GTTGCA/GGTGAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ASB4 (95107756 - 95169544 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ASB4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB4
    DNA2.0 Custom Variant and Variant Library Synthesis for ASB4

    Disorders / Diseases
    for ASB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ASB4 for disorders           About MalaCards

    ASB4 for disorders           About GeneDecksing

    OMIM gene information: 605761    OMIM disorders: --


    Export disorders for ASB4 gene to outside databases

    Publications
    for ASB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASB4 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ASB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PubMed id 11111040)1, 2, 9 Kile B.T....Alexander W.S. (2000)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. (PubMed id 17276034)1, 9 Li J.Y....Mulholland M.W. (2007)
    5. ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. (PubMed id 17636018)1, 9 Ferguson J.E....Patterson C. (2007)
    6. Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits. (PubMed id 15929745)1 Li J.Y....Gantz I. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1 Kile B.T....Hilton D.J. (2002)

    External Searches for ASB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ASB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51666 HGNC: 16009 AceView: ASB4 Ensembl:ENSG00000005981 euGenes: HUgn51666
    ECgene: ASB4 H-InvDB: ASB4

    Other Databases showing ASB4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ASB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASB4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ASB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ASB4 gene:
    Search GeneIP for patents involving ASB4

    GeneCards and IP:
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