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Aliases for ASB4 Gene

Aliases for ASB4 Gene

  • Ankyrin Repeat And SOCS Box Containing 4 2 3
  • Ankyrin Repeat And SOCS Box-Containing 4 2 3
  • ASB-4 3 4
  • Ankyrin Repeat And SOCS Box Protein 4 3

External Ids for ASB4 Gene

Summaries for ASB4 Gene

Entrez Gene Summary for ASB4 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASB4 Gene

ASB4 (Ankyrin Repeat And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin protein ligase binding. An important paralog of this gene is ASB10.

UniProtKB/Swiss-Prot for ASB4 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB4 Gene

Genomics for ASB4 Gene

Genomic Location for ASB4 Gene

Start:
95,478,444 bp from pter
End:
95,540,232 bp from pter
Size:
61,789 bases
Orientation:
Plus strand

Genomic View for ASB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB4 Gene

Regulatory Elements for ASB4 Gene

Proteins for ASB4 Gene

  • Protein details for ASB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y574-ASB4_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 4
    Protein Accession:
    Q9Y574
    Secondary Accessions:
    • A4D1H6
    • O14586
    • Q14D68
    • Q8TBT2

    Protein attributes for ASB4 Gene

    Size:
    426 amino acids
    Molecular mass:
    48195 Da
    Quaternary structure:
    • Interacts with HIF1AN. Component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex formed of CUL2 or CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and ASB4

    Alternative splice isoforms for ASB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB4 Gene

Proteomics data for ASB4 Gene at MOPED

Post-translational modifications for ASB4 Gene

  • Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB4 Gene

Domains for ASB4 Gene

Gene Families for ASB4 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB4 Gene

Suggested Antigen Peptide Sequences for ASB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y574

UniProtKB/Swiss-Prot:

ASB4_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.:
    • Q9Y574
  • Contains 1 SOCS box domain.:
    • Q9Y574
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.:
    • Q9Y574
Similarity:
  • Contains 6 ANK repeats.:
    • Q9Y574
genes like me logo Genes that share domains with ASB4: view

Function for ASB4 Gene

Molecular function for ASB4 Gene

UniProtKB/Swiss-Prot Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).

Gene Ontology (GO) - Molecular Function for ASB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding --
GO:0019899 enzyme binding --
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with ASB4: view
genes like me logo Genes that share phenotypes with ASB4: view

miRNA for ASB4 Gene

miRTarBase miRNAs that target ASB4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASB4 Gene

Localization for ASB4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB4 Gene COMPARTMENTS Subcellular localization image for ASB4 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ASB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031462 Cul2-RING ubiquitin ligase complex IDA 17636018
GO:0031466 Cul5-RING ubiquitin ligase complex IDA 17636018
genes like me logo Genes that share ontologies with ASB4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB4 Gene

Pathways for ASB4 Gene

genes like me logo Genes that share pathways with ASB4: view

UniProtKB/Swiss-Prot Q9Y574-ASB4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
GO:0051865 protein autoubiquitination IEA --
GO:2001214 positive regulation of vasculogenesis ISS --
genes like me logo Genes that share ontologies with ASB4: view

Transcripts for ASB4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ASB4 Gene

No ASD Table

Relevant External Links for ASB4 Gene

GeneLoc Exon Structure for
ASB4
ECgene alternative splicing isoforms for
ASB4

Expression for ASB4 Gene

mRNA expression in normal human tissues for ASB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB4 Gene

This gene is overexpressed in Adrenal Gland (25.3), Muscle - Skeletal (7.7), and Pituitary (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB4 Gene

SOURCE GeneReport for Unigene cluster for ASB4 Gene Hs.602765

genes like me logo Genes that share expressions with ASB4: view

No data available for mRNA Expression by UniProt/SwissProt for ASB4 Gene

Orthologs for ASB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB4 35
  • 99.53 (n)
  • 99.77 (a)
ASB4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB4 35
  • 91.39 (n)
  • 95.07 (a)
ASB4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB4 35
  • 91.84 (n)
  • 95.53 (a)
ASB4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb4 35
  • 85.68 (n)
  • 92.49 (a)
Asb4 16
Asb4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASB4 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb4 35
  • 85.37 (n)
  • 92.02 (a)
chicken
(Gallus gallus)
Aves ASB4 35
  • 73.33 (n)
  • 74.12 (a)
ASB4 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB4 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb4 35
  • 68.26 (n)
  • 70.33 (a)
Str.12472 35
zebrafish
(Danio rerio)
Actinopterygii asb4 35
  • 61.95 (n)
  • 59.47 (a)
asb4 36
  • 57 (a)
OneToOne
Species with no ortholog for ASB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB4 Gene

ENSEMBL:
Gene Tree for ASB4 (if available)
TreeFam:
Gene Tree for ASB4 (if available)

Paralogs for ASB4 Gene

Paralogs for ASB4 Gene

Selected SIMAP similar genes for ASB4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASB4: view

Variants for ASB4 Gene

Sequence variations from dbSNP and Humsavar for ASB4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs342 -- 95,489,283(-) ATCCA(A/G)TAGCT intron-variant
rs43066 -- 95,484,880(+) ACCAA(A/T)ATATC upstream-variant-2KB
rs43067 -- 95,485,392(+) CTCCC(C/T)TCCCA upstream-variant-2KB
rs43068 -- 95,485,618(+) TATTG(A/T)GGGGA upstream-variant-2KB
rs43069 -- 95,486,650(+) TAAAG(C/T)GGTGC intron-variant

Relevant External Links for ASB4 Gene

HapMap Linkage Disequilibrium report
ASB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASB4 Gene

Disorders for ASB4 Gene

No disorders were found for ASB4 Gene.

No data available for UniProtKB/Swiss-Prot for ASB4 Gene

Publications for ASB4 Gene

  1. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PMID: 11111040) Kile B.T. … Alexander W.S. (Gene 2000) 3 4 23
  2. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. (PMID: 17276034) Li J.Y. … Mulholland M.W. (Cell. Signal. 2007) 3 23
  3. ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. (PMID: 17636018) Ferguson J.E. … Patterson C. (Mol. Cell. Biol. 2007) 3 23
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for ASB4 Gene

Sources for ASB4 Gene

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