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ASB4 Gene(Protein Coding)

Ankyrin Repeat And SOCS Box Containing 4

GCID:
GC07P095461
GIFtS:
44
Genes Participants
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Aliases for ASB4 Gene

Aliases for ASB4 Gene

  • Ankyrin Repeat And SOCS Box Containing 4 2 3 5
  • ASB-4 3 4
  • Ankyrin Repeat And SOCS Box-Containing 4 2
  • Ankyrin Repeat And SOCS Box Protein 4 3

External Ids for ASB4 Gene

Previous GeneCards Identifiers for ASB4 Gene

  • GC07P093650
  • GC07P094713
  • GC07P094727
  • GC07P094759
  • GC07P094953
  • GC07P095107
  • GC07P089722
  • GC07P095478

Summaries for ASB4 Gene

Entrez Gene Summary for ASB4 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASB4 Gene

ASB4 (Ankyrin Repeat And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include enzyme binding and ubiquitin protein ligase binding. An important paralog of this gene is ASB18.

UniProtKB/Swiss-Prot for ASB4 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB4 Gene

Genomics for ASB4 Gene

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  1. Regulatory Element

Regulatory Elements for ASB4 Gene

Enhancers for ASB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G095395 0.9 ENCODE 25.5 -64.7 -64653 2.3 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 KLF13 MXD4 ASB4 PON3 ENSG00000273138
GH07G095420 0.7 ENCODE 28.9 -40.2 -40180 1.5 SOX5 SOX13 TRIM22 CEBPB CEBPG DPF2 TBX21 EP300 PRDM6 TARDBP ASB4 PON2 PON3 PON1 ENSG00000273138
GH07G095499 1.2 FANTOM5 ENCODE 13.2 +39.4 39403 3.4 HDGF PKNOX1 FOXA2 TBL1XR1 SIN3A BMI1 ZBTB40 RARA GATA2 RCOR1 ASB4 ENSG00000233942 ENSG00000231170 GC07M095530
GH07G095429 1.4 Ensembl ENCODE 11.3 -28.7 -28747 6.8 HDGF FOXA2 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 PON3 PON2 ASB4 PON1 ENSG00000233942 ENSG00000273138
GH07G095509 0.9 FANTOM5 ENCODE 12.2 +48.0 47953 0.4 ZNF664 RFX1 RFX3 IKZF1 MAX BMI1 EP300 ZNF7 ASB4 ENSG00000233942 GC07M095530
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ASB4 gene promoter:

Genomic Location for ASB4 Gene

Chromosome:
7
Start:
95,461,542 bp from pter
End:
95,540,232 bp from pter
Size:
78,691 bases
Orientation:
Plus strand

Genomic View for ASB4 Gene

Genes around ASB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ASB4 Gene

Proteins for ASB4 Gene

Products:

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  • Protein details for ASB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y574-ASB4_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 4
    Protein Accession:
    Q9Y574
    Secondary Accessions:
    • A4D1H6
    • O14586
    • Q14D68
    • Q8TBT2

    Protein attributes for ASB4 Gene

    Size:
    426 amino acids
    Molecular mass:
    48195 Da
    Quaternary structure:
    • Interacts with HIF1AN. Component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex formed of CUL2 or CUL5, Elongin BC (ELOB and ELOC), RBX1 and ASB4.

    Alternative splice isoforms for ASB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB4 Gene

Protein Expression for ASB4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ASB4 Gene

  • Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB4 Gene

Domains & Families for ASB4 Gene

Gene Families for ASB4 Gene

HGNC:

Protein Domains for ASB4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ASB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y574

UniProtKB/Swiss-Prot:

ASB4_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB4: view

Function for ASB4 Gene

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  7. Flow Cytometry

Molecular function for ASB4 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).

Gene Ontology (GO) - Molecular Function for ASB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0019899 enzyme binding IEA --
GO:0031625 ubiquitin protein ligase binding IBA,IEA --
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with ASB4: view
genes like me logo Genes that share phenotypes with ASB4: view

Animal Models for ASB4 Gene

MGI Knock Outs for ASB4:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASB4 Gene

Localization for ASB4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB4 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ASB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0031462 Cul2-RING ubiquitin ligase complex IDA 17636018
GO:0031466 Cul5-RING ubiquitin ligase complex IDA 17636018
genes like me logo Genes that share ontologies with ASB4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB4 Gene

Pathways & Interactions for ASB4 Gene

genes like me logo Genes that share pathways with ASB4: view

UniProtKB/Swiss-Prot Q9Y574-ASB4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
GO:0051865 protein autoubiquitination IEA --
GO:2001214 positive regulation of vasculogenesis IEA,ISS --
genes like me logo Genes that share ontologies with ASB4: view

No data available for SIGNOR curated interactions for ASB4 Gene

Drugs & Compounds for ASB4 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for ASB4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ASB4 Gene

(3) REFSEQ mRNAs :
(44) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB4 Gene

No ASD Table

Relevant External Links for ASB4 Gene

GeneLoc Exon Structure for
ASB4
ECgene alternative splicing isoforms for
ASB4

Expression for ASB4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB4 Gene

mRNA expression in normal human tissues for ASB4 Gene
mRNA expression by BioGPS for ASB4 GenemRNA expression by GTEx for ASB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB4 Gene

This gene is overexpressed in Adrenal Gland (x25.3), Muscle - Skeletal (x7.7), and Pituitary (x4.5).

Protein differential expression in normal tissues from HIPED for ASB4 Gene

This gene is overexpressed in Liver, secretome (41.1) and Heart (27.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB4 Gene



Protein tissue co-expression partners for ASB4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB4 Gene:

ASB4

SOURCE GeneReport for Unigene cluster for ASB4 Gene:

Hs.602765

Evidence on tissue expression from TISSUES for ASB4 Gene

  • Adrenal gland(4.3)
genes like me logo Genes that share expression patterns with ASB4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB4 Gene

Orthologs for ASB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ASB4 34 35
  • 99.53 (n)
dog
(Canis familiaris)
 Mammalia ASB4 34 35
  • 91.84 (n)
cow
(Bos Taurus)
 Mammalia ASB4 34 35
  • 91.39 (n)
mouse
(Mus musculus)
 Mammalia Asb4 34 16 35
  • 85.68 (n)
rat
(Rattus norvegicus)
 Mammalia Asb4 34
  • 85.37 (n)
oppossum
(Monodelphis domestica)
 Mammalia ASB4 35
  • 55 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ASB4 34 35
  • 73.33 (n)
lizard
(Anolis carolinensis)
 Reptilia ASB4 35
  • 69 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia asb4 34
  • 68.26 (n)
Str.12472 34
zebrafish
(Danio rerio)
 Actinopterygii asb4 34 35
  • 61.95 (n)
Species where no ortholog for ASB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB4 Gene

ENSEMBL:
Gene Tree for ASB4 (if available)
TreeFam:
Gene Tree for ASB4 (if available)

Paralogs for ASB4 Gene

Paralogs for ASB4 Gene

(3) SIMAP similar genes for ASB4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASB4: view

Variants for ASB4 Gene

Sequence variations from dbSNP and Humsavar for ASB4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000049174 -- 95,496,745(+) CAGGA(G/T)ACTGA intron-variant
rs1000056134 -- 95,502,267(+) AAATG(A/G)CAATT intron-variant
rs1000110419 -- 95,510,454(+) GATCA(A/G)TTTCT intron-variant
rs1000115896 -- 95,498,131(+) TCAGC(A/G)ATGTA intron-variant
rs1000118602 -- 95,543,622(+) GGCCC(C/T)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB4 Gene

Variant ID Type Subtype PubMed ID
nsv1023193 CNV gain 25217958

Variation tolerance for ASB4 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB4 Gene

Disorders for ASB4 Gene

Relevant External Links for ASB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB4

No disorders were found for ASB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB4 Gene

Publications for ASB4 Gene

  1. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PMID: 11111040) Kile B.T. … Alexander W.S. (Gene 2000) 3 4 22 64
  2. ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. (PMID: 17636018) Ferguson J.E. … Patterson C. (Mol. Cell. Biol. 2007) 3 22 64
  3. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. (PMID: 17276034) Li J.Y. … Mulholland M.W. (Cell. Signal. 2007) 3 22 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for ASB4 Gene

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