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Aliases for ASB4 Gene

Aliases for ASB4 Gene

  • Ankyrin Repeat And SOCS Box Containing 4 2 3 5
  • Ankyrin Repeat And SOCS Box-Containing 4 2 3
  • ASB-4 3 4

External Ids for ASB4 Gene

Previous GeneCards Identifiers for ASB4 Gene

  • GC07P093650
  • GC07P094713
  • GC07P094727
  • GC07P094759
  • GC07P094953
  • GC07P095107
  • GC07P089722
  • GC07P095478

Summaries for ASB4 Gene

Entrez Gene Summary for ASB4 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASB4 Gene

ASB4 (Ankyrin Repeat And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include enzyme binding and ubiquitin protein ligase binding. An important paralog of this gene is ASB10.

UniProtKB/Swiss-Prot for ASB4 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB4 Gene

Genomics for ASB4 Gene

Regulatory Elements for ASB4 Gene

Enhancers for ASB4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ASB4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB4 Gene

Chromosome:
7
Start:
95,461,542 bp from pter
End:
95,540,232 bp from pter
Size:
78,691 bases
Orientation:
Plus strand

Genomic View for ASB4 Gene

Genes around ASB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB4 Gene

Proteins for ASB4 Gene

  • Protein details for ASB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y574-ASB4_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 4
    Protein Accession:
    Q9Y574
    Secondary Accessions:
    • A4D1H6
    • O14586
    • Q14D68
    • Q8TBT2

    Protein attributes for ASB4 Gene

    Size:
    426 amino acids
    Molecular mass:
    48195 Da
    Quaternary structure:
    • Interacts with HIF1AN. Component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex formed of CUL2 or CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and ASB4.

    Alternative splice isoforms for ASB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB4 Gene

Proteomics data for ASB4 Gene at MOPED

Post-translational modifications for ASB4 Gene

  • Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ASB4

No data available for DME Specific Peptides for ASB4 Gene

Domains & Families for ASB4 Gene

Gene Families for ASB4 Gene

Protein Domains for ASB4 Gene

Suggested Antigen Peptide Sequences for ASB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y574

UniProtKB/Swiss-Prot:

ASB4_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 6 ANK repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ASB4: view

Function for ASB4 Gene

Molecular function for ASB4 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).
genes like me logo Genes that share phenotypes with ASB4: view

Animal Models for ASB4 Gene

MGI Knock Outs for ASB4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASB4 Gene

Localization for ASB4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB4 Gene COMPARTMENTS Subcellular localization image for ASB4 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ASB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031462 Cul2-RING ubiquitin ligase complex IEA,IDA 17636018
genes like me logo Genes that share ontologies with ASB4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB4 Gene

Pathways & Interactions for ASB4 Gene

genes like me logo Genes that share pathways with ASB4: view

UniProtKB/Swiss-Prot Q9Y574-ASB4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB4 Gene

None

No data available for SIGNOR curated interactions for ASB4 Gene

Drugs & Compounds for ASB4 Gene

No Compound Related Data Available

Transcripts for ASB4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ASB4 Gene

No ASD Table

Relevant External Links for ASB4 Gene

GeneLoc Exon Structure for
ASB4
ECgene alternative splicing isoforms for
ASB4

Expression for ASB4 Gene

mRNA expression in normal human tissues for ASB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB4 Gene

This gene is overexpressed in Adrenal Gland (x25.3), Muscle - Skeletal (x7.7), and Pituitary (x4.5).

Protein differential expression in normal tissues from HIPED for ASB4 Gene

This gene is overexpressed in Liver, secretome (41.1) and Heart (27.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB4 Gene



SOURCE GeneReport for Unigene cluster for ASB4 Gene Hs.602765

genes like me logo Genes that share expression patterns with ASB4: view

Protein tissue co-expression partners for ASB4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ASB4 Gene

Orthologs for ASB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASB4 35
  • 91.39 (n)
  • 95.07 (a)
ASB4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB4 35
  • 91.84 (n)
  • 95.53 (a)
ASB4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb4 35
  • 85.68 (n)
  • 92.49 (a)
Asb4 16
Asb4 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASB4 35
  • 99.53 (n)
  • 99.77 (a)
ASB4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb4 35
  • 85.37 (n)
  • 92.02 (a)
oppossum
(Monodelphis domestica)
Mammalia ASB4 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB4 35
  • 73.33 (n)
  • 74.12 (a)
ASB4 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB4 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb4 35
  • 68.26 (n)
  • 70.33 (a)
Str.12472 35
zebrafish
(Danio rerio)
Actinopterygii asb4 35
  • 61.95 (n)
  • 59.47 (a)
asb4 36
  • 57 (a)
OneToOne
Species with no ortholog for ASB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB4 Gene

ENSEMBL:
Gene Tree for ASB4 (if available)
TreeFam:
Gene Tree for ASB4 (if available)

Paralogs for ASB4 Gene

Paralogs for ASB4 Gene

(3) SIMAP similar genes for ASB4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASB4: view

Variants for ASB4 Gene

Sequence variations from dbSNP and Humsavar for ASB4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35047380 - 95,486,020(-) CTTAA(C/G)TAACT intron-variant, reference, missense
rs1015882 -- 95,467,303(+) cacag(C/T)ttgtg intron-variant
rs1015883 -- 95,467,335(+) atttc(C/T)GAACC intron-variant
rs1015884 -- 95,467,356(+) TTCAC(A/G)AAAAT intron-variant
rs1034467 -- 95,468,016(+) GAGAT(A/G)GGTGT intron-variant

Variation tolerance for ASB4 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB4 Gene

HapMap Linkage Disequilibrium report
ASB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ASB4 Gene

Disorders for ASB4 Gene

Relevant External Links for ASB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB4

No disorders were found for ASB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB4 Gene

Publications for ASB4 Gene

  1. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PMID: 11111040) Kile B.T. … Alexander W.S. (Gene 2000) 3 4 23 67
  2. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. (PMID: 17276034) Li J.Y. … Mulholland M.W. (Cell. Signal. 2007) 3 23
  3. ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. (PMID: 17636018) Ferguson J.E. … Patterson C. (Mol. Cell. Biol. 2007) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for ASB4 Gene

Sources for ASB4 Gene

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