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Aliases for ASB3 Gene

Aliases for ASB3 Gene

  • Ankyrin Repeat And SOCS Box Containing 3 2 3 5
  • ASB-3 3 4
  • Ankyrin Repeat And SOCS Box-Containing 3 2

External Ids for ASB3 Gene

Previous GeneCards Identifiers for ASB3 Gene

  • GC02M053935
  • GC02M054083
  • GC02M053871
  • GC02M053808
  • GC02M053613
  • GC02M053750
  • GC02M053898

Summaries for ASB3 Gene

Entrez Gene Summary for ASB3 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASB3 Gene

ASB3 (Ankyrin Repeat And SOCS Box Containing 3) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is ASB15.

UniProtKB/Swiss-Prot for ASB3 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.

Gene Wiki entry for ASB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB3 Gene

Genomics for ASB3 Gene

Regulatory Elements for ASB3 Gene

Promoters for ASB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ASB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB3 Gene

Chromosome:
2
Start:
53,532,672 bp from pter
End:
53,787,610 bp from pter
Size:
254,939 bases
Orientation:
Minus strand

Genomic View for ASB3 Gene

Genes around ASB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB3 Gene

Proteins for ASB3 Gene

  • Protein details for ASB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y575-ASB3_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 3
    Protein Accession:
    Q9Y575
    Secondary Accessions:
    • B3KPA3
    • D6W5B4
    • D6W5B5
    • G8JLA9
    • Q2TAI4
    • Q53TN0
    • Q53TN8
    • Q9NVZ2

    Protein attributes for ASB3 Gene

    Size:
    518 amino acids
    Molecular mass:
    57745 Da
    Quaternary structure:
    • Interacts with TCEB2 and TNFRSF1B.
    SequenceCaution:
    • Sequence=AAI10916.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB3 Gene

Proteomics data for ASB3 Gene at MOPED

Post-translational modifications for ASB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB3 Gene

Antibody Products

No data available for DME Specific Peptides for ASB3 Gene

Domains & Families for ASB3 Gene

Gene Families for ASB3 Gene

Protein Domains for ASB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y575

UniProtKB/Swiss-Prot:

ASB3_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 11 ANK repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 11 ANK repeats.
genes like me logo Genes that share domains with ASB3: view

Function for ASB3 Gene

Molecular function for ASB3 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.

Phenotypes for ASB3 Gene

GenomeRNAi human phenotypes for ASB3:
genes like me logo Genes that share phenotypes with ASB3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB3 Gene

Localization for ASB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB3 Gene COMPARTMENTS Subcellular localization image for ASB3 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB3 Gene

Pathways & Interactions for ASB3 Gene

genes like me logo Genes that share pathways with ASB3: view

UniProtKB/Swiss-Prot Q9Y575-ASB3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for ASB3 Gene

Gene Ontology (GO) - Biological Process for ASB3 Gene

None

No data available for SIGNOR curated interactions for ASB3 Gene

Drugs & Compounds for ASB3 Gene

No Compound Related Data Available

Transcripts for ASB3 Gene

Unigene Clusters for ASB3 Gene

Ankyrin repeat and SOCS box containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - -
SP11: - - - - - - - - -
SP12: - - - -

Relevant External Links for ASB3 Gene

GeneLoc Exon Structure for
ASB3
ECgene alternative splicing isoforms for
ASB3

Expression for ASB3 Gene

mRNA expression in normal human tissues for ASB3 Gene

mRNA expression in normal human tissues for ASB3 Gene

Protein differential expression in normal tissues from HIPED for ASB3 Gene

This gene is overexpressed in Lung (62.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ASB3 Gene



SOURCE GeneReport for Unigene cluster for ASB3 Gene Hs.40763

genes like me logo Genes that share expression patterns with ASB3: view

Protein tissue co-expression partners for ASB3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ASB3 Gene

Orthologs for ASB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASB3 35
  • 90.41 (n)
  • 87.84 (a)
-- 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ASB3 35
  • 89.51 (n)
  • 89 (a)
ASB3 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Asb3 35
  • 86.23 (n)
  • 83.78 (a)
Asb3 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ASB3 35
  • 99.55 (n)
  • 99.61 (a)
ASB3 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Asb3 35
  • 86.23 (n)
  • 83.98 (a)
oppossum
(Monodelphis domestica)
Mammalia ASB3 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves ASB3 35
  • 65.62 (n)
  • 63.19 (a)
ASB3 36
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia asb3 35
  • 62.39 (n)
  • 58.78 (a)
zebrafish
(Danio rerio)
Actinopterygii asb3 35
  • 52.83 (n)
  • 46.91 (a)
wufi36b12 35
asb3 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M60.7 36
  • 20 (a)
OneToMany
Species with no ortholog for ASB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASB3 Gene

ENSEMBL:
Gene Tree for ASB3 (if available)
TreeFam:
Gene Tree for ASB3 (if available)

Paralogs for ASB3 Gene

Paralogs for ASB3 Gene

(1) SIMAP similar genes for ASB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASB3: view

Variants for ASB3 Gene

Sequence variations from dbSNP and Humsavar for ASB3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs994484 -- 53,669,630(+) AAACT(C/G)AAACC downstream-variant-500B
rs60725156 -- 53,669,786(+) ATTTT(C/T)TATGT downstream-variant-500B
rs114770761 -- 53,669,588(+) CTGAT(G/T)AAAAT downstream-variant-500B
rs116356891 -- 53,669,551(+) TTAAA(C/G)ATGGT downstream-variant-500B
rs142496900 -- 53,669,626(+) CTCAA(A/C)ACTGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ASB3 Gene

Variant ID Type Subtype PubMed ID
esv2720076 CNV Deletion 23290073
esv2661223 CNV Deletion 23128226
nsv834058 CNV Gain+Loss 17160897
nsv2730 CNV Insertion 18451855

Variation tolerance for ASB3 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB3 Gene

HapMap Linkage Disequilibrium report
ASB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB3 Gene

Disorders for ASB3 Gene

Relevant External Links for ASB3

Human Genome Epidemiology (HuGE) Navigator
ASB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB3

No disorders were found for ASB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB3 Gene

Publications for ASB3 Gene

  1. Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II. (PMID: 15899873) Chung A.S. … Chin Y.E. (Mol. Cell. Biol. 2005) 2 3 4 67
  2. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PMID: 11111040) Kile B.T. … Alexander W.S. (Gene 2000) 3 23
  3. Genome-wide association study of short-acting I^2-agonists. A novel genome-wide significant locus on chromosome 2 near ASB3. (PMID: 25562107) Israel E. … Tantisira K.G. (Am. J. Respir. Crit. Care Med. 2015) 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for ASB3 Gene

Sources for ASB3 Gene

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