Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASB3 Gene

Aliases for ASB3 Gene

  • Ankyrin Repeat And SOCS Box Containing 3 2 3 5
  • ASB-3 3 4
  • Ankyrin Repeat And SOCS Box-Containing 3 2
  • Ankyrin Repeat And SOCS Box Protein 3 3

External Ids for ASB3 Gene

Previous GeneCards Identifiers for ASB3 Gene

  • GC02M053935
  • GC02M054083
  • GC02M053871
  • GC02M053808
  • GC02M053613
  • GC02M053750
  • GC02M053898

Summaries for ASB3 Gene

Entrez Gene Summary for ASB3 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASB3 Gene

ASB3 (Ankyrin Repeat And SOCS Box Containing 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is GPR75-ASB3.

UniProtKB/Swiss-Prot for ASB3 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.

Gene Wiki entry for ASB3 Gene

Additional gene information for ASB3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB3 Gene

Genomics for ASB3 Gene

Regulatory Elements for ASB3 Gene

Enhancers for ASB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H053811 0.7 ENCODE 11.9 -25.3 -25348 2 HLF CEBPB CEBPG EP300 ATF2 ZNF316 MAFF ATF3 ATF7 EMSY ERLEC1 ASB3 ACYP2 PIR55664
GH02H053785 1.1 ENCODE 4.8 +0.6 616 2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 ACYP2 ASB3 GPR75 ERLEC1
GH02H053993 1.2 FANTOM5 Ensembl ENCODE 4 -207.0 -207001 2 ZNF362 ZC3H11A JUNB ZNF781 ZNF518A ZNF697 ZNF555 ZBTB33 RUNX3 ACYP2 HMGB1P31 ASB3 PSME4 GC02P053991 GC02P054007
GH02H053766 1 ENCODE 4.3 +19.6 19615 2 PKNOX1 ARNT ARID4B SIN3A DMAP1 BRCA1 YY1 ETS1 ZNF766 ZNF143 ACYP2 ASB3 CHAC2 ERLEC1
GH02H053967 1.7 FANTOM5 ENCODE dbSUPER 1.5 -182.4 -182421 4 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 ACYP2 HMGB1P31 PSME4 ASB3 GPR75-ASB3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB3 on UCSC Golden Path with GeneCards custom track

Promoters for ASB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000117113 510 2601 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5

Genomic Location for ASB3 Gene

Chromosome:
2
Start:
53,532,672 bp from pter
End:
53,787,610 bp from pter
Size:
254,939 bases
Orientation:
Minus strand

Genomic View for ASB3 Gene

Genes around ASB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB3 Gene

Proteins for ASB3 Gene

  • Protein details for ASB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y575-ASB3_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 3
    Protein Accession:
    Q9Y575
    Secondary Accessions:
    • B3KPA3
    • D6W5B4
    • D6W5B5
    • G8JLA9
    • Q2TAI4
    • Q53TN0
    • Q53TN8
    • Q9NVZ2

    Protein attributes for ASB3 Gene

    Size:
    518 amino acids
    Molecular mass:
    57745 Da
    Quaternary structure:
    • Interacts with ELOB and TNFRSF1B.
    SequenceCaution:
    • Sequence=AAI10916.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB3 Gene

Post-translational modifications for ASB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB3 Gene

No data available for DME Specific Peptides for ASB3 Gene

Domains & Families for ASB3 Gene

Gene Families for ASB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9Y575

UniProtKB/Swiss-Prot:

ASB3_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB3: view

Function for ASB3 Gene

Molecular function for ASB3 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.

Phenotypes From GWAS Catalog for ASB3 Gene

Gene Ontology (GO) - Molecular Function for ASB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 25814554
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with ASB3: view

Phenotypes for ASB3 Gene

GenomeRNAi human phenotypes for ASB3:
genes like me logo Genes that share phenotypes with ASB3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ASB3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB3 Gene

Localization for ASB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB3 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ASB3 Gene

Pathways & Interactions for ASB3 Gene

genes like me logo Genes that share pathways with ASB3: view

UniProtKB/Swiss-Prot Q9Y575-ASB3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for ASB3 Gene

Gene Ontology (GO) - Biological Process for ASB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB3: view

No data available for SIGNOR curated interactions for ASB3 Gene

Drugs & Compounds for ASB3 Gene

No Compound Related Data Available

Transcripts for ASB3 Gene

Unigene Clusters for ASB3 Gene

Ankyrin repeat and SOCS box containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ASB3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ASB3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - -
SP11: - - - - - - - - -
SP12: - - - -

Relevant External Links for ASB3 Gene

GeneLoc Exon Structure for
ASB3
ECgene alternative splicing isoforms for
ASB3

Expression for ASB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB3 Gene

mRNA expression in normal human tissues for ASB3 Gene

Protein differential expression in normal tissues from HIPED for ASB3 Gene

This gene is overexpressed in Lung (62.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ASB3 Gene



Protein tissue co-expression partners for ASB3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB3 Gene:

ASB3

SOURCE GeneReport for Unigene cluster for ASB3 Gene:

Hs.40763

Evidence on tissue expression from TISSUES for ASB3 Gene

  • Nervous system(4.8)
  • Kidney(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ASB3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB3 Gene

Orthologs for ASB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB3 34 33
  • 99.55 (n)
OneToMany
cow
(Bos Taurus)
Mammalia ASB3 33
  • 90.41 (n)
-- 34
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ASB3 34 33
  • 89.51 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Asb3 34 33
  • 86.23 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Asb3 33
  • 86.23 (n)
oppossum
(Monodelphis domestica)
Mammalia ASB3 34
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves ASB3 34 33
  • 65.62 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia asb3 33
  • 62.39 (n)
zebrafish
(Danio rerio)
Actinopterygii asb3 34 33
  • 52.83 (n)
OneToMany
wufi36b12 33
worm
(Caenorhabditis elegans)
Secernentea M60.7 34
  • 20 (a)
OneToMany
Species where no ortholog for ASB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASB3 Gene

ENSEMBL:
Gene Tree for ASB3 (if available)
TreeFam:
Gene Tree for ASB3 (if available)

Paralogs for ASB3 Gene

Paralogs for ASB3 Gene

(1) SIMAP similar genes for ASB3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASB3: view

Variants for ASB3 Gene

Sequence variations from dbSNP and Humsavar for ASB3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000000715 -- 53,747,139(+) GACTC(-/TAA)TAATA intron-variant
rs1000007414 -- 53,678,579(+) GCACA(C/T)CACAA intron-variant
rs1000007816 -- 53,706,106(+) TTAGG(-/T)GTTAT intron-variant
rs1000039238 -- 53,712,963(+) AAAAT(A/C)CTATG intron-variant
rs1000041208 -- 53,780,494(+) CAAGC(A/C)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB3 Gene

Variant ID Type Subtype PubMed ID
dgv1913n106 CNV deletion 24896259
dgv3844n100 CNV loss 25217958
esv2661223 CNV deletion 23128226
esv2720076 CNV deletion 23290073
esv3556877 CNV deletion 23714750
esv3583829 CNV loss 25503493
nsv1009829 CNV loss 25217958
nsv2730 CNV insertion 18451855
nsv834058 CNV gain+loss 17160897
nsv979005 CNV duplication 23825009

Variation tolerance for ASB3 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB3 Gene

Disorders for ASB3 Gene

Relevant External Links for ASB3

Human Genome Epidemiology (HuGE) Navigator
ASB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB3

No disorders were found for ASB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB3 Gene

Publications for ASB3 Gene

  1. Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II. (PMID: 15899873) Chung AS … Chin YE (Molecular and cellular biology 2005) 2 3 4 60
  2. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PMID: 11111040) Kile BT … Alexander WS (Gene 2000) 3 4 22 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ASB3 Gene

Sources for ASB3 Gene

Content
Loading form....