Aliases for ASB3 Gene
Aliases for ASB3 Gene
External Ids for ASB3 Gene
- HGNC: 16013
- Entrez Gene: 51130
- Ensembl: ENSG00000115239
- OMIM: 605760
- UniProtKB: Q9Y575
Previous GeneCards Identifiers for ASB3 Gene
- GC02M053935
- GC02M054083
- GC02M053871
- GC02M053808
- GC02M053613
- GC02M053750
- GC02M053898
Summaries for ASB3 Gene
-
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for ASB3 Gene
ASB3 (Ankyrin Repeat And SOCS Box Containing 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is GPR75-ASB3.
UniProtKB/Swiss-Prot for ASB3 Gene
-
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB3 Gene
Genomics for ASB3 Gene
Regulatory Elements for ASB3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G053811 | 0.7 | ENCODE | 11.9 | -25.3 | -25348 | 2.5 | ZSCAN4 HLF CEBPB NR3C1 CEBPG EP300 ATF2 JUND MAFF ZNF316 | ASB3 ERLEC1 ACYP2 PIR55664 |
| GH02G053785 | 1.1 | ENCODE | 4.7 | +0.6 | 616 | 3.0 | HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A | ACYP2 ASB3 GPR75 ERLEC1 |
| GH02G053993 | 1.2 | FANTOM5 Ensembl ENCODE | 4 | -207.0 | -207001 | 2.8 | ZNF362 JUNB ZNF426 ZNF394 ZNF781 ZNF518A ZNF697 ZNF555 ZNF34 ZBTB33 | ACYP2 HMGB1P31 ASB3 PSME4 GC02P053991 GC02P054007 |
| GH02G053766 | 1.1 | ENCODE | 4.3 | +19.6 | 19615 | 2.5 | PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 | ACYP2 ASB3 CHAC2 ERLEC1 |
| GH02G053967 | 1.7 | FANTOM5 ENCODE dbSUPER | 1.5 | -182.4 | -182421 | 4.7 | PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 | ACYP2 HMGB1P31 PSME4 ASB3 GPR75-ASB3 |
- Transcription factor binding sites by QIAGEN in the ASB3 gene promoter:
Regulatory Element Products
Genomic Location for ASB3 Gene
- Chromosome:
- 2
- Start:
- 53,532,672 bp from pter
- End:
- 53,787,610 bp from pter
- Size:
- 254,939 bases
- Orientation:
- Minus strand
Genomic View for ASB3 Gene
- Cytogenetic band:
-
- 2p16.2 by Ensembl
- 2p16.2 by Entrez Gene
- 2p16.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASB3 Gene
Proteins for ASB3 Gene
-
Protein details for ASB3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y575-ASB3_HUMAN
- Recommended name:
- Ankyrin repeat and SOCS box protein 3
- Protein Accession:
- Q9Y575
- B3KPA3
- D6W5B4
- D6W5B5
- G8JLA9
- Q2TAI4
- Q53TN0
- Q53TN8
- Q9NVZ2
Protein attributes for ASB3 Gene
- Size:
- 518 amino acids
- Molecular mass:
- 57745 Da
- Quaternary structure:
-
- Interacts with ELOB and TNFRSF1B.
- SequenceCaution:
-
- Sequence=AAI10916.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for ASB3 Gene
Post-translational modifications for ASB3 Gene
Other Protein References for ASB3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ASB3
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Protein Products
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Assay Products
- antibodies-online Kits for ASB3: See all 9
No data available for DME Specific Peptides for ASB3 Gene
Domains & Families for ASB3 Gene
Gene Families for ASB3 Gene
Protein Domains for ASB3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASB3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y575UniProtKB/Swiss-Prot:
ASB3_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Belongs to the ankyrin SOCS box (ASB) family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Family:
-
- Belongs to the ankyrin SOCS box (ASB) family.
Function for ASB3 Gene
Molecular function for ASB3 Gene
- UniProtKB/Swiss-Prot Function:
- Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IBA | -- |
| GO:0005515 | protein binding | IPI | 25814554 |
| GO:0031625 | ubiquitin protein ligase binding | IBA | -- |
Phenotypes for ASB3 Gene
- GenomeRNAi human phenotypes for ASB3:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB3 gene
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CRISPR Products
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miRNA for ASB3 Gene
- miRTarBase miRNAs that target ASB3
-
- hsa-mir-335-5p (MIRT018047)
- hsa-mir-935 (MIRT036646)
- hsa-mir-615-3p (MIRT040170)
- hsa-mir-30a-5p (MIRT088933)
- hsa-mir-30c-5p (MIRT088934)
- hsa-mir-30d-5p (MIRT088935)
- hsa-mir-30b-5p (MIRT088936)
- hsa-mir-30e-5p (MIRT088938)
- hsa-mir-342-3p (MIRT527248)
- hsa-mir-1285-5p (MIRT527249)
- hsa-mir-193b-3p (MIRT728291)
- hsa-mir-193a-3p (MIRT728292)
miRNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
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-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB3 Gene
Localization for ASB3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IBA | -- |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB3 Gene
Pathways & Interactions for ASB3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for ASB3 Gene
UniProtKB/Swiss-Prot Q9Y575-ASB3_HUMAN
- Pathway: Protein modification; protein ubiquitination.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for ASB3 Gene
Transcripts for ASB3 Gene
mRNA/cDNA for ASB3 Gene
- (3) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (198) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASB3 Gene
- Ankyrin repeat and SOCS box containing 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ASB3
-
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miRNA Products
- Search ViGene Biosciences for ASB3
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for ASB3
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-
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Clone Products
- Sino Biological Human cDNA Clone for ASB3
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- VectorBuilder custom plasmid, inducible vectors for ASB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - |
Expression for ASB3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ASB3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ASB3 Gene:
ASB3SOURCE GeneReport for Unigene cluster for ASB3 Gene:
Hs.40763Evidence on tissue expression from TISSUES for ASB3 Gene
- Nervous system(4.8)
- Kidney(4.2)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs for ASB3
-
OriGene qPCR primer pairs and template standards for ASB3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB3 Gene
Orthologs for ASB3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASB3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASB3 34 |
|
||
| -- 35 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | ASB3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Asb3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asb3 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ASB3 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | ASB3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | asb3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | asb3 34 35 |
|
||
| wufi36b12 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | M60.7 35 |
|
OneToMany |
- Species where no ortholog for ASB3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ASB3 Gene
Paralogs for ASB3 Gene
- GPR75-ASB3 5
- ASB14 5
- ASB2 5
- ASB15 5
- GPR75-ASB3 34
(1) SIMAP similar genes for ASB3 Gene using alignment to 1 proteins:
Variants for ASB3 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000000715 | -- | 53,747,139(+) | GACTC(-/TAA)TAATA | intron-variant | |
| rs1000007414 | -- | 53,678,579(+) | GCACA(C/T)CACAA | intron-variant | |
| rs1000007816 | -- | 53,706,106(+) | TTAGG(-/T)GTTAT | intron-variant | |
| rs1000039238 | -- | 53,712,963(+) | AAAAT(A/C)CTATG | intron-variant | |
| rs1000041208 | -- | 53,780,494(+) | CAAGC(A/C)GAGGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1913n106 | CNV | deletion | 24896259 |
| dgv3844n100 | CNV | loss | 25217958 |
| esv2661223 | CNV | deletion | 23128226 |
| esv2720076 | CNV | deletion | 23290073 |
| esv3556877 | CNV | deletion | 23714750 |
| esv3583829 | CNV | loss | 25503493 |
| nsv1009829 | CNV | loss | 25217958 |
| nsv2730 | CNV | insertion | 18451855 |
| nsv834058 | CNV | gain+loss | 17160897 |
| nsv979005 | CNV | duplication | 23825009 |
Relevant External Links for ASB3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASB3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB3 Gene
Disorders for ASB3 Gene
Relevant External Links for ASB3
No disorders were found for ASB3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB3 Gene
Publications for ASB3 Gene
- Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and degradation of tumor necrosis factor receptor II. (PMID: 15899873) Chung A.S. … Chin Y.E. (Mol. Cell. Biol. 2005) 2 3 4 64
- Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PMID: 11111040) Kile B.T. … Alexander W.S. (Gene 2000) 3 4 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
Products for ASB3 Gene
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- Search ViGene Biosciences for ASB3
- Horizon Cell Lines for ASB3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASB3
- VectorBuilder custom plasmid, inducible vectors for ASB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASB3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
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