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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASB2 Gene

protein-coding   GIFtS: 55
GCID: GC14M094400

ankyrin repeat and SOCS box containing 2

(Previous name: ankyrin repeat and SOCS box-containing 2 )
 Explore 4 diseases affiliated with
ASB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ASB2    

Aliases
for ASB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ankyrin Repeat And SOCS Box Containing 21 2
ASB-21 2 3
Ankyrin Repeat And SOCS Box-Containing 21
Ankyrin Repeat And SOCS Box Protein 22
Ankyrin Repeat And SOCS Box-Containing Protein 2a2

External Ids:    HGNC: 160121   Entrez Gene: 516762   Ensembl: ENSG000001006287   OMIM: 6057595   UniProtKB: Q96Q273   

Export aliases for ASB2 gene to outside databases

Previous GC identifers: GC14M091907 GC14M088217 GC14M092390 GC14M093470 GC14M074580


Summaries
for ASB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ASB2:
This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a
role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex.
The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of
actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of
myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for
this gene. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: ASB2_HUMAN, Q96Q27
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
proteins

Gene Wiki entry for ASB2


Genomic Views
for ASB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASB2 gene promoter:
         E2F-4   E2F-3a   E2F-5   GATA-3   E2F-2   GATA-2   YY1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ASB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ASB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31-q32   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q31-q32

ASB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M094400:  view genomic region     (about GC identifiers)

Start:
 94,400,499 bp from pter      End:
 94,443,137 bp from pter
Size:
 42,639 bases      Orientation:
 minus strand

Proteins
for ASB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ASB2_HUMAN, Q96Q27 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 2  
Size: 587 amino acids; 65084 Da
Subunit: Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2,
Elongin BC complex (TCEB1 and TCEB2) and ASB2
Secondary accessions: B2RDP9 B4E166 Q9NSU5 Q9Y567
Alternative splicing: 2 isoforms:  Q96Q27-1   Q96Q27-2   

Explore the universe of human proteins at neXtProt for ASB2: NX_Q96Q27

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96Q27

    • ASB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001189358.1  NP_057234.2  

    ENSEMBL proteins: 
     ENSP00000451575   ENSP00000320675   ENSP00000450940   ENSP00000451694   ENSP00000451654  
     ENSP00000451355  
    Reactome Protein details: Q96Q27
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ASB2
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ASB2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----


    ASB2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ASB2

    Protein Domains /
    Families
    for ASB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ASB2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001496 SOCS_C
     IPR020683 Ankyrin_rpt-contain_dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q96Q27

    ProtoNet protein and cluster: Q96Q27

    2 Blocks protein families:
    IPB001496 SOCS protein
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ASB2_HUMAN, Q96Q27
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3
    ubiquitin-protein ligase complexes (By similarity)
    Similarity: Contains 12 ANK repeats
    Similarity: Contains 1 SOCS box domain


    Function
    for ASB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ASB2_HUMAN, Q96Q27
    Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
    proteins
    Induction: By all-trans retinoic acid (ATRA)

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB2:
    hsa-miR-2117 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmid: ASB2 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: ASB2
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB2 

    Cell Line
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    Search LifeMap BioReagents cell lines for ASB2

    In Situ Assay
    Products:       
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    Pathways & Interactions
    for ASB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for ASB2
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: ASB2_HUMAN, Q96Q27
    Pathway: Protein modification; protein ubiquitination


    ASB2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/18 Interacting proteins for ASB2 (Q96Q272, 3 ENSP000003206754) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL5Q930342, 3MINT-75029 MINT-77968 MINT-1786035 MINT-7986036 I2D: score=2 
    RNF7Q9UBF62, 3, ENSP000002734804MINT-75030 MINT-77969 I2D: score=2 STRING: ENSP00000273480
    SMAD9O151982, 3MINT-62147 I2D: score=3 
    TCEB2Q153703, ENSP000002623064I2D: score=3 STRING: ENSP00000262306
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9419338
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--


    ASB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ASB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ASB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ASB2
    1 Novoseek chemical compound relationship for ASB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 56.6 5 11682484 (2), 18799729 (1), 19118439 (1)

    Search CenterWatch for drugs/clinical trials and news about ASB2 

    Transcripts
    for ASB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ASB2 gene (2 alternative transcripts): 
    NM_001202429.1  NM_016150.4  

    Unigene Cluster for ASB2:

    Ankyrin repeat and SOCS box containing 2
    Hs.510327  [show with all ESTs]
    Unigene Representative Sequence: AB488462
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555019(uc001ycd.3) ENST00000315988(uc001ycc.2) ENST00000553883(uc001ycb.2)
    ENST00000555507(uc001yce.1) ENST00000556337 ENST00000556062 ENST00000555287
    ENST00000556793 ENST00000557613 ENST00000555374

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ASB2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB2:
    hsa-miR-2117 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmid: ASB2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB2 (see all 7)
    OriGene shRNA RFP: ASB2
    OriGene siRNA: ASB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ASB2 (NM_016150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB2

    Additional cDNA sequence: 

    AB056723.1 AB488462.1 AF159164.1 AJ251238.1 AK093271.1 AK303686.1 AK315628.1 AL137735.1 
    BC032354.1 

    10 DOTS entries:

    DT.411634  DT.100781417  DT.91787841  DT.95222152  DT.100020873  DT.430991  DT.91742313  DT.95268911 
    DT.120788112  DT.40251954 

    24/79 AceView cDNA sequences (see all 79):

    AI681453 AA180234 AA761908 CD627574 BE219722 AI872284 AA247746 AW770858 
    BE856129 AA192619 AA768364 BX956363 BM545130 AK093271 NM_016150 AI970956 
    AJ251238 AI989416 AA195225 AW510603 AK002049 BE744504 AA196388 AB056723 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ASB2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9
    SP1:              -     -           -                                         -                                 
    SP2:                                -                                         -                                 
    SP3:                                -           -     -     -     -           -                                 
    SP4:                                                                                                            
    SP5:                                -     -     -                                                               


    ECgene alternative splicing isoforms for ASB2

    Expression
    for ASB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTCTACGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ASB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    Head MesenchymeHead MesenchymeHead Mesenchyme
    HeartOutflow TractHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See ASB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASB2

    SOURCE GeneReport for Unigene cluster: Hs.510327
        SABiosciences Expression via Pathway-Focused PCR Arrays including ASB2: 
              T Helper Cell Differentiation in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB2

    Orthologs
    for ASB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASB2 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Asb21 , 5 ankyrin repeat and SOCS box-containing 21, 5 86.65(n)1
    90.22(a)1    		   12 (52.90 cM)5
    652561  NM_023049.11  NP_075536.11 
     1033211425 
    chicken
    (Gallus gallus)    		 Aves ASB21 ankyrin repeat and SOCS box containing 2 68.3(n)
    71.32(a)    		   423428  XM_421337.3  XP_421337.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 71(a)
    67(a)
    		 many → 1
    many → 1
    		 AAWZ02040758(2238-5789)
    1(10369311-10397508)
    zebrafish
    (Danio rerio)    		 Actinopterygii asb2a1 ankyrin repeat and SOCS box-containing 2a 56.66(n)
    55.27(a)    		   567986  XM_691298.5  XP_696390.3 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    		 --
    		 28(a)
    22(a)
    		 possible ortholog
    possible ortholog
    		 GroupUn.2402(3656-4465)
    GroupUn.141(13787-29536)
    worm
    (Caenorhabditis elegans)    		 Secernentea M60.76
    		 Protein M60.7
    		 17(a)
    		 possible ortholog
    		 X(8258435-8261124)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons TPR106
    		 ankyrin repeat family protein
    		 10(a)
    		 1 → many
    		 3(1276668-1281118)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 30)    		 conserved hypothetical protein
    ankyrin repeat domain containing protein, putative...
    (see all 30)    		 9(a)
    22(a)
    (see all 30)    		 many ↔ many
    many ↔ many
    (see all 30)    		 3(26971657-26979129)
    2(17190218-17198761)


    ENSEMBL Gene Tree for ASB2 (if available)
    TreeFam Gene Tree for ASB2 (if available) 

    Paralogs
    for ASB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASB2 gene
    ASB152  ASB32  ASB142  
    16 SIMAP similar genes for ASB2 using alignment to 5 protein entries:     ASB2_HUMAN (see all proteins):
    ANK2    ASB3    ASB14    ANK3    ANKRD54    IkBa
    RAI14    ANKRD44    ASB15    ANKRD10    GABPB1    ANKRD29
    ANKRD42    PSMD10    DKFZp761E1322    MTPN

    ASB2 for paralogs           About GeneDecksing



    Genomic Variants
    for ASB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/967 NCBI SNPs in ASB2 are shown (see all 967)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1481735291,2
    		C,other94423193(+) CCGGCA/GAACTC 4 S L mis10--------
    rs1931160551,2
    		--94400002(+) AATTCC/GTGCTC 2 -- ds50010--------
    rs1847599781,2
    		--94400141(+) GCCAGC/TATTTA 2 -- ds50010--------
    rs1492814061,2
    		--94400244(+) GGTGTC/TGGGAG 2 -- ds50010--------
    rs1434421861,2
    		--94400245(+) GTGTCA/GGGAGA 2 -- ds50010--------
    rs767528961,2
    		F,--94400333(+) CATCCG/AGTCTT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1479882671,2
    		--94400344(+) GCCTGA/GGGAGT 2 -- ds50010--------
    rs80040281,2
    		C,H,--94400368(+) TCTTGG/AGTCTT 2 -- ds50014Minor allele frequency- A:0.00NS EA 402
    rs1134029581,2
    		C,--94400394(+) TGACAC/TGTTCA 2 -- ds50012Minor allele frequency- T:0.07NA 122
    rs116255481,2
    		C,F,A,H,--94400431(+) CTGCCT/CCGCTC 2 -- ds500112Minor allele frequency- C:0.49NA WA CSA EA 375

    HapMap Linkage Disequilibrium report for ASB2 (94400499 - 94443137 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ASB2: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ASB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ASB2 for disorders           About GeneDecksing

    OMIM gene information: 605759    OMIM disorders: --

    4 diseases for ASB2:    About MalaCards
    myeloid leukemia    mucopolysaccharidosis vi    leukemia    mucopolysaccharidosis

    1 disease from the University of Copenhagen DISEASES database for ASB2:
    Mucopolysaccharidosis VI

    3 Novoseek disease relationships for ASB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia promyelocytic acute 81.1 4 18799729 (1), 15590664 (1), 19376791 (1)
    myeloid leukemia 69.3 5 11682484 (2), 15590664 (1), 19376791 (1)
    leukemia 35.6 4 18799729 (2), 11566180 (1), 15590664 (1)


    Export disorders for ASB2 gene to outside databases

    Publications
    for ASB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASB2 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with ASB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ASB2 is an elongin BC-interacting protein that can assemble with cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex. (PubMed id 15590664)1, 2, 9 Heuze M.L.... Lutz P.G. (2005)
    2. ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells. (PubMed id 11682484)1, 2, 9 Guibal F.C.... Cayre Y.E. (2002)
    3. ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells. (PubMed id 11566180)1, 2, 9 Kohroki J.... Tanaka K. (2001)
    4. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PubMed id 11111040)1, 2, 9 Kile B.T....Alexander W.S. (2000)
    5. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1, 2 Kohroki J.... Masuho Y. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. ASB2 targets filamins A and B to proteasomal degradation. (PubMed id 18799729)1, 9 Heuze M.L....Lutz P.G. (2008)
    9. A label-free quantitative proteomics strategy to iden tify E3 ubiquitin ligase substrates targeted to proteasome degradation. (PubMed id 19376791)1, 9 Burande C.F....Lutz P.G. (2009)
    10. ECSASB2 mediates MLL degradation during hematopoietic differentiation. (PubMed id 22174154)1 Wang J....Hess J.L. (2012)

    External Searches for ASB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing ASB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51676 HGNC: 16012 AceView: ASB2 Ensembl:ENSG00000100628 euGenes: HUgn51676
    ECgene: ASB2 H-InvDB: ASB2

    Other Databases showing ASB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ASB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ASB2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ASB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ASB2 gene:
    Search GeneIP for patents involving ASB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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