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Aliases for ASB2 Gene

Aliases for ASB2 Gene

  • Ankyrin Repeat And SOCS Box Containing 2 2 3
  • ASB-2 3 4
  • Ankyrin Repeat And SOCS Box-Containing Protein 2a 3
  • Ankyrin Repeat And SOCS Box-Containing 2 2
  • Ankyrin Repeat And SOCS Box Protein 2 3

External Ids for ASB2 Gene

Previous GeneCards Identifiers for ASB2 Gene

  • GC14M091907
  • GC14M088217
  • GC14M092390
  • GC14M093470
  • GC14M094400
  • GC14M074580

Summaries for ASB2 Gene

Entrez Gene Summary for ASB2 Gene

  • This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASB2 Gene

ASB2 (Ankyrin Repeat And SOCS Box Containing 2) is a Protein Coding gene. Diseases associated with ASB2 include myeloid leukemia. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ASB15.

UniProtKB/Swiss-Prot for ASB2 Gene

  • Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

  • Isoform 1: Enhances adhesion of hematopoietic cells to fibronectin through targeting of filamins FLNA and FLNB for proteasomal degradation, it is transiantly expressed during hematopoietic cell differentiation.

  • Isoform 2: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA.

Gene Wiki entry for ASB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB2 Gene

Genomics for ASB2 Gene

Regulatory Elements for ASB2 Gene

Genomic Location for ASB2 Gene

Start:
93,934,153 bp from pter
End:
93,976,791 bp from pter
Size:
42,639 bases
Orientation:
Minus strand

Genomic View for ASB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB2 Gene

Proteins for ASB2 Gene

  • Protein details for ASB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96Q27-ASB2_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 2
    Protein Accession:
    Q96Q27
    Secondary Accessions:
    • B2RDP9
    • B4E166
    • Q9NSU5
    • Q9Y567

    Protein attributes for ASB2 Gene

    Size:
    587 amino acids
    Molecular mass:
    65084 Da
    Quaternary structure:
    • Component of a probable ECS E3 ubiquitin-protein ligase complex which contains CUL5, either RBX1 or RNF7/RBX2, Elongin BC complex (TCEB1 and TCEB2) and ASB2.

    Alternative splice isoforms for ASB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB2 Gene

Proteomics data for ASB2 Gene at MOPED

Post-translational modifications for ASB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB2 Gene

No data available for DME Specific Peptides for ASB2 Gene

Domains for ASB2 Gene

Gene Families for ASB2 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96Q27

UniProtKB/Swiss-Prot:

ASB2_HUMAN :
  • Q96Q27
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Both the N-terminus and ANK repeats 1 to 10 are necessary for interaction with filamins.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 12 ANK repeats.
genes like me logo Genes that share domains with ASB2: view

Function for ASB2 Gene

Molecular function for ASB2 Gene

UniProtKB/Swiss-Prot Function: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
UniProtKB/Swiss-Prot Function: Isoform 1: Enhances adhesion of hematopoietic cells to fibronectin through targeting of filamins FLNA and FLNB for proteasomal degradation, it is transiantly expressed during hematopoietic cell differentiation.
UniProtKB/Swiss-Prot Function: Isoform 2: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA.
UniProtKB/Swiss-Prot Induction: By all-trans retinoic acid (ATRA).

Gene Ontology (GO) - Molecular Function for ASB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 16325183
genes like me logo Genes that share ontologies with ASB2: view

Phenotypes for ASB2 Gene

MGI mutant phenotypes for ASB2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ASB2: view

Animal Model Products

CRISPR Products

miRNA for ASB2 Gene

miRTarBase miRNAs that target ASB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASB2 Gene

Localization for ASB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB2 Gene COMPARTMENTS Subcellular localization image for ASB2 gene
Compartment Confidence
cytosol 3
mitochondrion 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ASB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031466 Cul5-RING ubiquitin ligase complex IEA --
genes like me logo Genes that share ontologies with ASB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB2 Gene

Pathways for ASB2 Gene

genes like me logo Genes that share pathways with ASB2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q96Q27-ASB2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007165 signal transduction TAS 9419338
GO:0035556 intracellular signal transduction IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with ASB2: view

Compounds for ASB2 Gene

(1) Novoseek inferred chemical compound relationships for ASB2 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 56.6 4
genes like me logo Genes that share compounds with ASB2: view

Transcripts for ASB2 Gene

Unigene Clusters for ASB2 Gene

Ankyrin repeat and SOCS box containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - -
SP3: - - - - - -
SP4:
SP5: - - -
SP6: - -

Relevant External Links for ASB2 Gene

GeneLoc Exon Structure for
ASB2
ECgene alternative splicing isoforms for
ASB2

Expression for ASB2 Gene

mRNA expression in normal human tissues for ASB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB2 Gene

This gene is overexpressed in Muscle - Skeletal (21.0) and Heart - Left Ventricle (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB2 Gene

SOURCE GeneReport for Unigene cluster for ASB2 Gene Hs.510327

genes like me logo Genes that share expressions with ASB2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ASB2 Gene

Orthologs for ASB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB2 35
  • 99.47 (n)
  • 99.3 (a)
ASB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB2 35
  • 88.94 (n)
  • 88.78 (a)
ASB2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB2 35
  • 88.04 (n)
  • 88.1 (a)
ASB2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb2 35
  • 86.65 (n)
  • 90.22 (a)
Asb2 16
Asb2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASB2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb2 35
  • 87.28 (n)
  • 90.54 (a)
chicken
(Gallus gallus)
Aves ASB2 35
  • 68.3 (n)
  • 71.32 (a)
ASB2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia asb2 35
  • 62.5 (n)
  • 64.08 (a)
zebrafish
(Danio rerio)
Actinopterygii asb2a.1 35
  • 56.49 (n)
  • 54.85 (a)
asb2a.1 36
  • 48 (a)
OneToMany
asb2a.1 36
  • 44 (a)
OneToMany
asb2b 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M60.7 36
  • 21 (a)
OneToMany
Species with no ortholog for ASB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASB2 Gene

ENSEMBL:
Gene Tree for ASB2 (if available)
TreeFam:
Gene Tree for ASB2 (if available)

Paralogs for ASB2 Gene

Paralogs for ASB2 Gene

genes like me logo Genes that share paralogs with ASB2: view

Variants for ASB2 Gene

Sequence variations from dbSNP and Humsavar for ASB2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs12370 -- 93,934,560(-) ACAGA(C/T)GAGGC utr-variant-3-prime
rs730958 -- 93,955,933(+) CCAGC(A/T)CTGGG intron-variant
rs730959 -- 93,956,000(+) GGGCG(A/G)CAGGA intron-variant
rs736849 -- 93,969,919(-) ACCAG(A/G)TACTG intron-variant, splice-donor-variant
rs941483 -- 93,956,277(+) CAAAT(A/T)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB2 Gene

Variant ID Type Subtype PubMed ID
nsv832861 CNV Loss 17160897
nsv1405 CNV Insertion 18451855

Relevant External Links for ASB2 Gene

HapMap Linkage Disequilibrium report
ASB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB2 Gene

Disorders for ASB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ASB2 Gene including...

Search for ASB2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ASB2 Gene

(3) Novoseek inferred disease relationships for ASB2 Gene

Disease -log(P) Hits PubMed IDs
leukemia promyelocytic acute 81.1 3
myeloid leukemia 69.3 4
leukemia 35.6 4

Relevant External Links for ASB2

Genetic Association Database (GAD)
ASB2
genes like me logo Genes that share disorders with ASB2: view

No data available for UniProtKB/Swiss-Prot for ASB2 Gene

Publications for ASB2 Gene

  1. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PMID: 11111040) Kile B.T. … Alexander W.S. (Gene 2000) 3 4 23
  2. ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells. (PMID: 11566180) Kohroki J. … Tanaka K. (FEBS Lett. 2001) 3 4 23
  3. ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells. (PMID: 11682484) Guibal F.C. … Cayre Y.E. (J. Biol. Chem. 2002) 3 4 23
  4. ASB2 is an elongin BC-interacting protein that can assemble with cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex. (PMID: 15590664) Heuze M.L. … Lutz P.G. (J. Biol. Chem. 2005) 3 4 23
  5. ASB2 targets filamins A and B to proteasomal degradation. (PMID: 18799729) HeuzAc M.L. … Lutz P.G. (Blood 2008) 3 23

Products for ASB2 Gene

Sources for ASB2 Gene

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