Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASB18 Gene

Aliases for ASB18 Gene

  • Ankyrin Repeat And SOCS Box Containing 18 2 3
  • Ankyrin Repeat And SOCS Box-Containing 18 2 3
  • ASB-18 3 4
  • Ankyrin Repeat And SOCS Box Protein 18 3

External Ids for ASB18 Gene

Summaries for ASB18 Gene

GeneCards Summary for ASB18 Gene

ASB18 (Ankyrin Repeat And SOCS Box Containing 18) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB10.

UniProtKB/Swiss-Prot for ASB18 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB18 Gene

Genomics for ASB18 Gene

Genomic Location for ASB18 Gene

Start:
236,194,872 bp from pter
End:
236,264,409 bp from pter
Size:
69,538 bases
Orientation:
Minus strand

Genomic View for ASB18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB18 Gene

Regulatory Elements for ASB18 Gene

Proteins for ASB18 Gene

  • Protein details for ASB18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVZ8-ASB18_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 18
    Protein Accession:
    Q6ZVZ8
    Secondary Accessions:
    • B6ZDL7

    Protein attributes for ASB18 Gene

    Size:
    466 amino acids
    Molecular mass:
    50803 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85710.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASB18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB18 Gene

Proteomics data for ASB18 Gene at MOPED

Post-translational modifications for ASB18 Gene

No Post-translational modifications

Other Protein References for ASB18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB18 Gene

Domains for ASB18 Gene

Gene Families for ASB18 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB18 Gene

UniProtKB/Swiss-Prot:

ASB18_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.:
    • Q6ZVZ8
  • Contains 1 SOCS box domain.:
    • Q6ZVZ8
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.:
    • Q6ZVZ8
Similarity:
  • Contains 6 ANK repeats.:
    • Q6ZVZ8
genes like me logo Genes that share domains with ASB18: view

Function for ASB18 Gene

Molecular function for ASB18 Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASB18: view

Phenotypes for ASB18 Gene

GenomeRNAi human phenotypes for ASB18:
genes like me logo Genes that share phenotypes with ASB18: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASB18 Gene

Localization for ASB18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB18 Gene COMPARTMENTS Subcellular localization image for ASB18 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for ASB18 Gene

Pathways for ASB18 Gene

genes like me logo Genes that share pathways with ASB18: view

UniProtKB/Swiss-Prot Q6ZVZ8-ASB18_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB18: view

Transcripts for ASB18 Gene

mRNA/cDNA for ASB18 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB18 Gene

Ankyrin repeat and SOCS box containing 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB18 Gene

No ASD Table

Relevant External Links for ASB18 Gene

GeneLoc Exon Structure for
ASB18
ECgene alternative splicing isoforms for
ASB18

Expression for ASB18 Gene

mRNA expression in normal human tissues for ASB18 Gene

mRNA differential expression in normal tissues according to GTEx for ASB18 Gene

This gene is overexpressed in Heart - Left Ventricle (23.7), Muscle - Skeletal (9.0), and Brain - Putamen (basal ganglia) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB18 Gene

SOURCE GeneReport for Unigene cluster for ASB18 Gene Hs.639909

genes like me logo Genes that share expressions with ASB18: view

Orthologs for ASB18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB18 36
  • 99.07 (n)
  • 99.14 (a)
ASB18 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB18 36
  • 87.12 (n)
  • 84.33 (a)
ASB18 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB18 36
  • 88.27 (n)
  • 84.3 (a)
ASB18 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb18 36
  • 80.86 (n)
  • 80 (a)
Asb18 16
Asb18 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB18 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb18 36
  • 80 (n)
  • 79.78 (a)
chicken
(Gallus gallus)
Aves ASB18 36
  • 65.02 (n)
  • 59.36 (a)
ASB18 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB18 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488546 36
  • 53.69 (n)
  • 46.39 (a)
zebrafish
(Danio rerio)
Actinopterygii asb18 37
  • 46 (a)
OneToOne
LOC792746 36
  • 52.9 (n)
  • 51.21 (a)
Species with no ortholog for ASB18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB18 Gene

ENSEMBL:
Gene Tree for ASB18 (if available)
TreeFam:
Gene Tree for ASB18 (if available)

Paralogs for ASB18 Gene

Paralogs for ASB18 Gene

Selected SIMAP similar genes for ASB18 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ASB18: view

Variants for ASB18 Gene

Sequence variations from dbSNP and Humsavar for ASB18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs719544 -- 236,209,639(-) CAGGC(G/T)GTGGT intron-variant
rs1002319 -- 236,241,735(+) CTCTT(G/T)GTGAT intron-variant
rs1073463 -- 236,209,453(-) ATCTC(C/T)ACAAA intron-variant
rs1254681 -- 236,196,412(+) CGCAG(C/T)GTAGG intron-variant
rs1349754 -- 236,211,071(+) CCTGA(C/G)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB18 Gene

Variant ID Type Subtype PubMed ID
esv33938 CNV Loss 17666407
nsv821922 CNV Gain 20364138
nsv821923 CNV Gain 20364138
nsv460143 CNV Loss 19166990
dgv4457n71 CNV Gain 21882294
nsv214473 CNV Loss 16902084
esv2721701 CNV Deletion 23290073

Relevant External Links for ASB18 Gene

HapMap Linkage Disequilibrium report
ASB18

Disorders for ASB18 Gene

Relevant External Links for ASB18

Genetic Association Database (GAD)
ASB18
genes like me logo Genes that share disorders with ASB18: view

No data available for UniProtKB/Swiss-Prot for ASB18 Gene

Publications for ASB18 Gene

  1. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 49
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3
  4. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. (PMID: 23722424) Rietveld C.A. … Koellinger P.D. (Science 2013) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for ASB18 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ASB18
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ASB18
    • Block miRNA regulation of ASB18 using miScript Target Protectors

    Sources for ASB18 Gene

    Back to Top

    Content