ASB18 Gene
protein-coding GIFtS: 40
GCID: GC02M237102
|
|
ankyrin repeat and SOCS box containing 18(Previous name: ankyrin repeat and SOCS box-containing 18 )
| |
Aliases
for ASB18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat And SOCS Box Containing 181 2 | | Ankyrin Repeat And SOCS Box-Containing 181 2 | | ASB-182 3 | | Ankyrin Repeat And SOCS Box Protein 182 |
Export aliases for ASB18 gene to outside databasesPrevious GC identifers: GC02U900024 GC02M237388 GC02M236884 GC02M236766 GC02M228898 |
Summaries
for ASB18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ASB18_HUMAN, Q6ZVZ8Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity)
|
Genomic Views
for ASB18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005120.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASB18 gene promoter:
MEF-2 POU3F2 YY1 Gfi-1 MEF-2A AREB6 POU2F1 Cart-1 aMEF-2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASB18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.2 Ensembl cytogenetic band: 2q37.2 HGNC cytogenetic band: 2q37.2ASB18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M237102: view genomic region
(about GC identifiers)
Start:
|
237,102,095 bp from pter |
End:
|
237,173,052 bp from pter |
Size:
|
70,958 bases |
Orientation:
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minus strand |
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Proteins
for ASB18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASB18_HUMAN, Q6ZVZ8 (See
protein sequence)Recommended Name: Ankyrin repeat and SOCS box protein 18 Size: 466 amino acids; 50803 Da
Sequence caution: Sequence=BAC85710.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites;
Secondary accessions: B6ZDL7Alternative splicing: 2 isoforms: Q6ZVZ8-1 Q6ZVZ8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ASB18: NX_Q6ZVZ8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZVZ8
ASB18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997721.2
ENSEMBL proteins: ENSP00000386532 ENSP00000411434 ENSP00000410021 ENSP00000329970 Reactome Protein details: Q6ZVZ8
Human Recombinant Protein Products for ASB18:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
ASB18 for ontologies About GeneDecksing
ASB18 Antibody Products:
Assay Products for ASB18: |
Protein
Domains /
Families
for ASB18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASB18 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZVZ8ProtoNet protein and cluster: Q6ZVZ8 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ASB18_HUMAN, Q6ZVZ8Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3ubiquitin-protein ligase complexes (By similarity)Similarity: Contains 6 ANK repeatsSimilarity: Contains 1 SOCS box domain |
Function
for ASB18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ASB18_HUMAN, Q6ZVZ8Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity)Phenotypes:
1 GenomeRNAi human phenotype for ASB18:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ASB18 (NM_212556) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASB18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB18 |
|
Pathways & Interactions
for ASB18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for ASB18
UniProtKB/Swiss-Prot: ASB18_HUMAN, Q6ZVZ8Pathway: Protein modification; protein ubiquitination
ASB18 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASB18
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- | | GO:0035556 | intracellular signal transduction |
IEA | -- |
ASB18 for ontologies About GeneDecksing
|
Drugs & Compounds
for ASB18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ASB18
Search CenterWatch for drugs/clinical trials and news about ASB18
|
Transcripts
for ASB18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASB18 gene: NM_212556.2 Unigene Cluster for ASB18: Ankyrin repeat and SOCS box containing 18 Hs.639909 [show with all ESTs]Unigene Representative Sequence: BX6475896 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409749(uc010znh.2) ENST00000447030 ENST00000430053 ENST00000487961
ENST00000469508 ENST00000330842(uc010fyp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB18
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ASB18 (NM_212556) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASB18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB18 |
Additional cDNA sequence: BX647589.1 2 DOTS entries: DT.101974863 DT.40229074 2 AceView cDNA sequences: AK123854 NM_212556
GeneLoc Exon Structure
|
Expression
for ASB18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASB18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ASB18 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.639909
SABiosciences Expression via Pathway-Focused PCR Array including ASB18:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASB18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB18 |
Orthologs
for ASB18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ASB18 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ASB181 |
ankyrin repeat and SOCS box containing 18 |
64.51(n)
58.03(a) |
|
424022 XM_421879.2 XP_421879.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ASB186 |
-- |
58(a) |
1 ↔ 1 |
1(119879301-119923607) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7927461 |
ankyrin repeat and SOCS box protein 18-like |
52.32(n)
48.94(a) |
|
792746 XM_001332292.2 XP_001332328.2 |
ENSEMBL Gene Tree for ASB18 (if available)
TreeFam Gene Tree for ASB18 (if available) |
Paralogs
for ASB18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ASB18 gene
- ASB162 ASB42 ASB102
4 SIMAP similar genes for ASB18 using alignment to 3 protein entries: ASB18_HUMAN (see all proteins):ASB16 ASB10 ASB4 ANKRD54
ASB18 for paralogs About GeneDecksing
|
Genomic Variants
for ASB18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASB18 (237102095 - 237173052 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ASB18
1 CNV: 7254 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB18 |
|
Disorders
/ Diseases
for ASB18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ASB18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASB18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASB18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (2002)
- Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1 Kohroki J.... Masuho Y. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for ASB18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ASB18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASB18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASB18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASB18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ASB18 gene:
Search GeneIP for patents involving ASB18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASB18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ASB18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB18 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ASB18 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
 |
 |
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 | | | ASB18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB18 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB18 |
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