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Aliases for ASB18 Gene

Aliases for ASB18 Gene

  • Ankyrin Repeat And SOCS Box Containing 18 2 3 5
  • Ankyrin Repeat And SOCS Box-Containing 18 2 3
  • ASB-18 3 4

External Ids for ASB18 Gene

Previous GeneCards Identifiers for ASB18 Gene

  • GC02U900024
  • GC02M237388
  • GC02M236884
  • GC02M236766
  • GC02M237102
  • GC02M228898

Summaries for ASB18 Gene

GeneCards Summary for ASB18 Gene

ASB18 (Ankyrin Repeat And SOCS Box Containing 18) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is ASB10.

UniProtKB/Swiss-Prot for ASB18 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB18 Gene

Genomics for ASB18 Gene

Regulatory Elements for ASB18 Gene

Genomic Location for ASB18 Gene

236,194,872 bp from pter
236,264,409 bp from pter
69,538 bases
Minus strand

Genomic View for ASB18 Gene

Genes around ASB18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB18 Gene

Proteins for ASB18 Gene

  • Protein details for ASB18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat and SOCS box protein 18
    Protein Accession:
    Secondary Accessions:
    • B6ZDL7

    Protein attributes for ASB18 Gene

    466 amino acids
    Molecular mass:
    50803 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85710.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASB18 Gene


neXtProt entry for ASB18 Gene

Proteomics data for ASB18 Gene at MOPED

Post-translational modifications for ASB18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB18 Gene

Domains & Families for ASB18 Gene

Gene Families for ASB18 Gene

Protein Domains for ASB18 Gene

Suggested Antigen Peptide Sequences for ASB18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 6 ANK repeats.
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ASB18: view

Function for ASB18 Gene

Molecular function for ASB18 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with ASB18: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB18 Gene

Localization for ASB18 Gene

Subcellular locations from

Jensen Localization Image for ASB18 Gene COMPARTMENTS Subcellular localization image for ASB18 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB18 Gene

Pathways & Interactions for ASB18 Gene

genes like me logo Genes that share pathways with ASB18: view

UniProtKB/Swiss-Prot Q6ZVZ8-ASB18_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB18 Gene


No data available for SIGNOR curated interactions for ASB18 Gene

Drugs & Compounds for ASB18 Gene

No Compound Related Data Available

Transcripts for ASB18 Gene

mRNA/cDNA for ASB18 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB18 Gene

Ankyrin repeat and SOCS box containing 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB18 Gene

No ASD Table

Relevant External Links for ASB18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASB18 Gene

mRNA expression in normal human tissues for ASB18 Gene

mRNA differential expression in normal tissues according to GTEx for ASB18 Gene

This gene is overexpressed in Heart - Left Ventricle (x23.7), Muscle - Skeletal (x9.0), and Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for ASB18 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB18 Gene

SOURCE GeneReport for Unigene cluster for ASB18 Gene Hs.639909

genes like me logo Genes that share expression patterns with ASB18: view

Protein tissue co-expression partners for ASB18 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ASB18 Gene

Orthologs for ASB18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ASB18 35
  • 87.12 (n)
  • 84.33 (a)
ASB18 36
  • 84 (a)
(Canis familiaris)
Mammalia ASB18 35
  • 88.27 (n)
  • 84.3 (a)
ASB18 36
  • 84 (a)
(Mus musculus)
Mammalia Asb18 35
  • 80.86 (n)
  • 80 (a)
Asb18 16
Asb18 36
  • 80 (a)
(Pan troglodytes)
Mammalia ASB18 35
  • 99.07 (n)
  • 99.14 (a)
ASB18 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Asb18 35
  • 80 (n)
  • 79.78 (a)
(Ornithorhynchus anatinus)
Mammalia ASB18 36
  • 46 (a)
(Gallus gallus)
Aves ASB18 35
  • 65.02 (n)
  • 59.36 (a)
ASB18 36
  • 56 (a)
(Anolis carolinensis)
Reptilia ASB18 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488546 35
  • 53.69 (n)
  • 46.39 (a)
(Danio rerio)
Actinopterygii LOC792746 35
  • 52.9 (n)
  • 51.21 (a)
asb18 36
  • 46 (a)
Species with no ortholog for ASB18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB18 Gene

Gene Tree for ASB18 (if available)
Gene Tree for ASB18 (if available)

Paralogs for ASB18 Gene

Paralogs for ASB18 Gene

(4) SIMAP similar genes for ASB18 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ASB18: view

Variants for ASB18 Gene

Sequence variations from dbSNP and Humsavar for ASB18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs7588748 - 236,214,461(+) GTCTG(C/G)AGCAC reference, synonymous-codon
rs6756597 - 236,241,298(+) CGTGG(C/T)TGGAG reference, missense
rs10177957 - 236,195,054(+) CTTGT(A/G/T)CATCT reference, missense
rs6431437 - 236,214,682(+) CGCAC(C/T)GCAGG reference, missense
rs719544 -- 236,209,639(-) CAGGC(G/T)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB18 Gene

Variant ID Type Subtype PubMed ID
esv33938 CNV Loss 17666407
nsv821922 CNV Gain 20364138
nsv821923 CNV Gain 20364138
nsv460143 CNV Loss 19166990
dgv4457n71 CNV Gain 21882294
nsv214473 CNV Loss 16902084
esv2721701 CNV Deletion 23290073

Variation tolerance for ASB18 Gene

Gene Damage Index Score: 15.27; 97.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB18 Gene

Disorders for ASB18 Gene

Relevant External Links for ASB18

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ASB18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB18 Gene

Publications for ASB18 Gene

  1. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 48 67
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. (PMID: 23722424) Rietveld C.A. … Koellinger P.D. (Science 2013) 3

Products for ASB18 Gene

Sources for ASB18 Gene

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