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Aliases for ASB18 Gene

Aliases for ASB18 Gene

  • Ankyrin Repeat And SOCS Box Containing 18 2 3 5
  • ASB-18 3 4
  • Ankyrin Repeat And SOCS Box-Containing 18 2
  • Ankyrin Repeat And SOCS Box Protein 18 3

External Ids for ASB18 Gene

Previous GeneCards Identifiers for ASB18 Gene

  • GC02U900024
  • GC02M237388
  • GC02M236884
  • GC02M236766
  • GC02M237102
  • GC02M228898

Summaries for ASB18 Gene

GeneCards Summary for ASB18 Gene

ASB18 (Ankyrin Repeat And SOCS Box Containing 18) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB10.

UniProtKB/Swiss-Prot for ASB18 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB18 Gene

Genomics for ASB18 Gene

Regulatory Elements for ASB18 Gene

Enhancers for ASB18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F236239 0.6 ENCODE 20.7 +23.9 23918 2.6 ZFHX2 GLIS1 TEAD4 MNT ZIC2 EGR2 TRIM28 ASB18 RNU1-31P GC02P236250 GC02M236211
GH02F236236 0.6 Ensembl 20.7 +27.1 27066 1.9 CTCF SUZ12 NFE2 NFE2L2 EZH2 ASB18 RNU1-31P GC02P236250 GC02M236211
GH02F236449 0.6 ENCODE 9.8 -185.0 -185024 0.2 ZNF687 MNT ZBTB40 MBD2 GATA3 ZFHX2 FOS EGR2 IQCA1 ASB18 PIR46430 PIR37038
GH02F236240 0.5 ENCODE 11.7 +25.3 25312 0.0 CBX3 ATF3 TRIM28 ASB18 RNU1-31P GC02P236250 GC02M236211
GH02F236173 0.9 Ensembl ENCODE 4.8 +89.3 89273 2.3 RNF2 CBX2 MAX ZIC2 ZBTB7A ZFHX2 GLIS1 ZNF652 EZH2 EGR2 LOC105373942 ASB18 GBX2 GC02M236211 RNU1-31P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB18 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB18 Gene

Chromosome:
2
Start:
236,194,872 bp from pter
End:
236,264,409 bp from pter
Size:
69,538 bases
Orientation:
Minus strand

Genomic View for ASB18 Gene

Genes around ASB18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB18 Gene

Proteins for ASB18 Gene

  • Protein details for ASB18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVZ8-ASB18_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 18
    Protein Accession:
    Q6ZVZ8
    Secondary Accessions:
    • B6ZDL7

    Protein attributes for ASB18 Gene

    Size:
    466 amino acids
    Molecular mass:
    50803 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85710.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASB18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB18 Gene

Post-translational modifications for ASB18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB18 Gene

Domains & Families for ASB18 Gene

Gene Families for ASB18 Gene

Protein Domains for ASB18 Gene

Suggested Antigen Peptide Sequences for ASB18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVZ8

UniProtKB/Swiss-Prot:

ASB18_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 6 ANK repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ASB18: view

Function for ASB18 Gene

Molecular function for ASB18 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with ASB18: view
genes like me logo Genes that share phenotypes with ASB18: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB18 Gene

Localization for ASB18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB18 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ASB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASB18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB18 Gene

Pathways & Interactions for ASB18 Gene

genes like me logo Genes that share pathways with ASB18: view

UniProtKB/Swiss-Prot Q6ZVZ8-ASB18_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB18: view

No data available for SIGNOR curated interactions for ASB18 Gene

Transcripts for ASB18 Gene

mRNA/cDNA for ASB18 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB18 Gene

Ankyrin repeat and SOCS box containing 18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB18 Gene

No ASD Table

Relevant External Links for ASB18 Gene

GeneLoc Exon Structure for
ASB18
ECgene alternative splicing isoforms for
ASB18

Expression for ASB18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASB18 Gene

mRNA differential expression in normal tissues according to GTEx for ASB18 Gene

This gene is overexpressed in Heart - Left Ventricle (x23.7), Muscle - Skeletal (x9.0), and Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for ASB18 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB18 Gene



Protein tissue co-expression partners for ASB18 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB18 Gene:

ASB18

SOURCE GeneReport for Unigene cluster for ASB18 Gene:

Hs.639909
genes like me logo Genes that share expression patterns with ASB18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ASB18 Gene

Orthologs for ASB18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB18 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia ASB18 34 35
  • 88.27 (n)
cow
(Bos Taurus)
Mammalia ASB18 34 35
  • 87.12 (n)
mouse
(Mus musculus)
Mammalia Asb18 34 16 35
  • 80.86 (n)
rat
(Rattus norvegicus)
Mammalia Asb18 34
  • 80 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ASB18 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB18 34 35
  • 65.02 (n)
lizard
(Anolis carolinensis)
Reptilia ASB18 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488546 34
  • 53.69 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC792746 34
  • 52.9 (n)
asb18 35
  • 46 (a)
OneToOne
Species where no ortholog for ASB18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB18 Gene

ENSEMBL:
Gene Tree for ASB18 (if available)
TreeFam:
Gene Tree for ASB18 (if available)

Paralogs for ASB18 Gene

Paralogs for ASB18 Gene

(4) SIMAP similar genes for ASB18 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ASB18: view

Variants for ASB18 Gene

Sequence variations from dbSNP and Humsavar for ASB18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1002319 -- 236,241,735(+) CTCTT(G/T)GTGAT intron-variant
rs10166966 -- 236,194,980(+) CGAAG(A/G)GCACA reference, synonymous-codon
rs10167618 -- 236,195,555(+) CTGTC(A/G)CCCAG intron-variant
rs10170326 -- 236,195,675(+) CATGC(C/T)TGGGT intron-variant
rs10172356 -- 236,260,832(+) GTCAT(C/T)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB18 Gene

Variant ID Type Subtype PubMed ID
nsv997438 CNV gain 25217958
nsv821923 CNV gain 20364138
nsv821922 CNV gain 20364138
nsv460143 CNV loss 19166990
nsv214473 CNV deletion 16902084
nsv1112780 CNV deletion 24896259
nsv1000252 CNV loss 25217958
esv3584380 CNV loss 25503493
esv3575342 CNV gain 25503493
esv33938 CNV loss 17666407
esv2721701 CNV deletion 23290073
dgv7342n54 CNV loss 21841781

Variation tolerance for ASB18 Gene

Gene Damage Index Score: 15.27; 97.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB18 Gene

Disorders for ASB18 Gene

Relevant External Links for ASB18

Genetic Association Database (GAD)
ASB18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB18

No disorders were found for ASB18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB18 Gene

Publications for ASB18 Gene

  1. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 46 64
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
  3. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3 64
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. (PMID: 23722424) Rietveld C.A. … Koellinger P.D. (Science 2013) 3 64

Products for ASB18 Gene

Sources for ASB18 Gene

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