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Aliases for ASB18 Gene

Aliases for ASB18 Gene

  • Ankyrin Repeat And SOCS Box Containing 18 2 3 5
  • ASB-18 3 4
  • Ankyrin Repeat And SOCS Box-Containing 18 2
  • Ankyrin Repeat And SOCS Box Protein 18 3

External Ids for ASB18 Gene

Previous GeneCards Identifiers for ASB18 Gene

  • GC02U900024
  • GC02M237388
  • GC02M236884
  • GC02M236766
  • GC02M237102
  • GC02M228898

Summaries for ASB18 Gene

Entrez Gene Summary for ASB18 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Feb 2017]

GeneCards Summary for ASB18 Gene

ASB18 (Ankyrin Repeat And SOCS Box Containing 18) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB10.

UniProtKB/Swiss-Prot for ASB18 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB18 Gene

Genomics for ASB18 Gene

Regulatory Elements for ASB18 Gene

Enhancers for ASB18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G236239 0.9 ENCODE dbSUPER 20.7 +23.9 23918 2.6 FOXA2 TEAD4 MNT ZIC2 ZFHX2 GLIS1 EGR2 TRIM28 ASB18 RNU1-31P GC02P236250 GC02M236211
GH02G236236 0.5 dbSUPER 20.7 +27.6 27630 1.2 CTCF SUZ12 EZH2 ASB18 RNU1-31P GC02P236250 GC02M236211
GH02G236240 0.7 ENCODE dbSUPER 11.7 +25.3 25312 0.0 CBX3 ATF3 TRIM28 ASB18 RNU1-31P GC02P236250 GC02M236211
GH02G236449 0.6 ENCODE 9.8 -185.0 -185024 0.2 ZNF687 MNT ZBTB40 MBD2 GATA3 ZFHX2 MTA1 TARDBP FOS EGR2 IQCA1 ASB18 PIR46430 PIR37038
GH02G236176 0.9 ENCODE dbSUPER 5.2 +87.8 87777 0.2 GATAD2A CTCF NFIA ZNF384 RAD21 ZNF664 TFDP1 IKZF1 ZNF341 ZKSCAN8 ASB18 GBX2 GC02M236211 RNU1-31P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB18 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB18 Gene

Chromosome:
2
Start:
236,194,872 bp from pter
End:
236,264,409 bp from pter
Size:
69,538 bases
Orientation:
Minus strand

Genomic View for ASB18 Gene

Genes around ASB18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB18 Gene

Proteins for ASB18 Gene

  • Protein details for ASB18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVZ8-ASB18_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 18
    Protein Accession:
    Q6ZVZ8
    Secondary Accessions:
    • B6ZDL7

    Protein attributes for ASB18 Gene

    Size:
    466 amino acids
    Molecular mass:
    50803 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85710.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};

    Alternative splice isoforms for ASB18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB18 Gene

Post-translational modifications for ASB18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB18 Gene

Domains & Families for ASB18 Gene

Gene Families for ASB18 Gene

Protein Domains for ASB18 Gene

Suggested Antigen Peptide Sequences for ASB18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVZ8

UniProtKB/Swiss-Prot:

ASB18_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB18: view

Function for ASB18 Gene

Molecular function for ASB18 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with ASB18: view
genes like me logo Genes that share phenotypes with ASB18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB18 Gene

Localization for ASB18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB18 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ASB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ASB18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB18 Gene

Pathways & Interactions for ASB18 Gene

genes like me logo Genes that share pathways with ASB18: view

UniProtKB/Swiss-Prot Q6ZVZ8-ASB18_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB18: view

No data available for SIGNOR curated interactions for ASB18 Gene

Drugs & Compounds for ASB18 Gene

No Compound Related Data Available

Transcripts for ASB18 Gene

mRNA/cDNA for ASB18 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB18 Gene

Ankyrin repeat and SOCS box containing 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB18 Gene

No ASD Table

Relevant External Links for ASB18 Gene

GeneLoc Exon Structure for
ASB18
ECgene alternative splicing isoforms for
ASB18

Expression for ASB18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB18 Gene

mRNA differential expression in normal tissues according to GTEx for ASB18 Gene

This gene is overexpressed in Heart - Left Ventricle (x23.7), Muscle - Skeletal (x9.0), and Brain - Putamen (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for ASB18 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB18 Gene



Protein tissue co-expression partners for ASB18 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB18 Gene:

ASB18

SOURCE GeneReport for Unigene cluster for ASB18 Gene:

Hs.639909
genes like me logo Genes that share expression patterns with ASB18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB18 Gene

Orthologs for ASB18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB18 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia ASB18 34 35
  • 88.27 (n)
cow
(Bos Taurus)
Mammalia ASB18 34 35
  • 87.12 (n)
mouse
(Mus musculus)
Mammalia Asb18 34 16 35
  • 80.86 (n)
rat
(Rattus norvegicus)
Mammalia Asb18 34
  • 80 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ASB18 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB18 34 35
  • 65.02 (n)
lizard
(Anolis carolinensis)
Reptilia ASB18 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488546 34
  • 53.69 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC792746 34
  • 52.9 (n)
asb18 35
  • 46 (a)
OneToOne
Species where no ortholog for ASB18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB18 Gene

ENSEMBL:
Gene Tree for ASB18 (if available)
TreeFam:
Gene Tree for ASB18 (if available)

Paralogs for ASB18 Gene

Paralogs for ASB18 Gene

(4) SIMAP similar genes for ASB18 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ASB18: view

Variants for ASB18 Gene

Sequence variations from dbSNP and Humsavar for ASB18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1057518421 Uncertain significance 236,214,769(-) GCCTG(C/G)ACGAG reference, missense
rs376567222 Uncertain significance 236,194,987(+) CACAG(C/T)GGCAA reference, missense
rs1000084152 -- 236,248,976(+) GGCAC(A/T)AGAAG intron-variant
rs1000102909 -- 236,246,652(+) ATGAC(C/G)AATAG intron-variant
rs1000119461 -- 236,237,294(+) CGTGG(-/CGCCTC)CCGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB18 Gene

Variant ID Type Subtype PubMed ID
dgv7342n54 CNV loss 21841781
esv2721701 CNV deletion 23290073
esv33938 CNV loss 17666407
esv3575342 CNV gain 25503493
esv3584380 CNV loss 25503493
nsv1000252 CNV loss 25217958
nsv1112780 CNV deletion 24896259
nsv214473 CNV deletion 16902084
nsv460143 CNV loss 19166990
nsv821922 CNV gain 20364138
nsv821923 CNV gain 20364138
nsv997438 CNV gain 25217958

Variation tolerance for ASB18 Gene

Gene Damage Index Score: 15.27; 97.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB18 Gene

Disorders for ASB18 Gene

Relevant External Links for ASB18

Genetic Association Database (GAD)
ASB18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB18

No disorders were found for ASB18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB18 Gene

Publications for ASB18 Gene

  1. Genome-wide association of lipid-lowering response to statins in combined study populations. (PMID: 20339536) Barber M.J. … Krauss R.M. (PLoS ONE 2010) 3 46 64
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
  3. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3 64
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. (PMID: 23722424) Rietveld C.A. … Koellinger P.D. (Science 2013) 3 64

Products for ASB18 Gene

Sources for ASB18 Gene

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