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Aliases for ASB17 Gene

Aliases for ASB17 Gene

  • Ankyrin Repeat And SOCS Box Containing 17 2 3
  • Ankyrin Repeat And SOCS Box-Containing 17 2 3
  • Asb-17 3 4
  • Ankyrin Repeat And SOCS Box Protein 17 3

External Ids for ASB17 Gene

Summaries for ASB17 Gene

GeneCards Summary for ASB17 Gene

ASB17 (Ankyrin Repeat And SOCS Box Containing 17) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for ASB17 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB17 Gene

Genomics for ASB17 Gene

Genomic Location for ASB17 Gene

75,918,873 bp from pter
75,932,431 bp from pter
13,559 bases
Minus strand

Genomic View for ASB17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB17 Gene

Regulatory Elements for ASB17 Gene

Proteins for ASB17 Gene

  • Protein details for ASB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat and SOCS box protein 17
    Protein Accession:
    Secondary Accessions:
    • B1APB8
    • Q8N0X5

    Protein attributes for ASB17 Gene

    295 amino acids
    Molecular mass:
    34282 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASB17 Gene

Proteomics data for ASB17 Gene at MOPED

Post-translational modifications for ASB17 Gene

No Post-translational modifications

Other Protein References for ASB17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB17 Gene

Domains for ASB17 Gene

Gene Families for ASB17 Gene

  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB17 Gene

Suggested Antigen Peptide Sequences for ASB17 Gene

Graphical View of Domain Structure for InterPro Entry



  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.:
    • Q8WXJ9
  • Contains 1 SOCS box domain.:
    • Q8WXJ9
  • Belongs to the ankyrin SOCS box (ASB) family.:
    • Q8WXJ9
  • Contains 1 ANK repeat.:
    • Q8WXJ9
genes like me logo Genes that share domains with ASB17: view

Function for ASB17 Gene

Molecular function for ASB17 Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes for ASB17 Gene

GenomeRNAi human phenotypes for ASB17:
genes like me logo Genes that share phenotypes with ASB17: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASB17 Gene

Localization for ASB17 Gene

Subcellular locations from

Jensen Localization Image for ASB17 Gene COMPARTMENTS Subcellular localization image for ASB17 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB17 Gene

Pathways for ASB17 Gene

genes like me logo Genes that share pathways with ASB17: view

UniProtKB/Swiss-Prot Q8WXJ9-ASB17_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for ASB17 Gene

Gene Ontology (GO) - Biological Process for ASB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB17: view

Transcripts for ASB17 Gene

mRNA/cDNA for ASB17 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB17 Gene

Ankyrin repeat and SOCS box containing 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB17 Gene

No ASD Table

Relevant External Links for ASB17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASB17 Gene

mRNA expression in normal human tissues for ASB17 Gene

mRNA differential expression in normal tissues according to GTEx for ASB17 Gene

This gene is overexpressed in Testis (52.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB17 Gene

SOURCE GeneReport for Unigene cluster for ASB17 Gene Hs.125423

genes like me logo Genes that share expressions with ASB17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ASB17 Gene

Orthologs for ASB17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ASB17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ASB17 35
  • 99.77 (n)
  • 99.66 (a)
ASB17 36
  • 100 (a)
(Bos Taurus)
Mammalia ASB17 35
  • 90.14 (n)
  • 86.73 (a)
ASB17 36
  • 86 (a)
(Canis familiaris)
Mammalia ASB17 35
  • 91.16 (n)
  • 90.1 (a)
ASB17 36
  • 89 (a)
(Mus musculus)
Mammalia Asb17 35
  • 84.69 (n)
  • 88.1 (a)
Asb17 16
Asb17 36
  • 88 (a)
(Monodelphis domestica)
Mammalia ASB17 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia ASB17 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Asb17 35
  • 85.37 (n)
  • 87.76 (a)
Species with no ortholog for ASB17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ASB17 Gene

Gene Tree for ASB17 (if available)
Gene Tree for ASB17 (if available)

Paralogs for ASB17 Gene

No data available for Paralogs for ASB17 Gene

Variants for ASB17 Gene

Sequence variations from dbSNP and Humsavar for ASB17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs968018 -- 75,929,977(+) AGGGG(A/G)GGTGA intron-variant
rs1417406 -- 75,927,735(-) AACCA(A/G)TTAGT intron-variant
rs1469988 -- 75,933,749(+) CTTGG(A/G)TGTAT upstream-variant-2KB
rs1628063 -- 75,925,961(+) CCTCA(A/G)CTGTC intron-variant
rs1630587 -- 75,934,102(-) TCTAT(A/G)GTGTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ASB17 Gene

Variant ID Type Subtype PubMed ID
nsv871671 CNV Loss 21882294
esv2605515 CNV Insertion 19546169
esv269155 CNV Insertion 20981092

Relevant External Links for ASB17 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB17 Gene

Disorders for ASB17 Gene

Relevant External Links for ASB17

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ASB17: view

No data available for UniProtKB/Swiss-Prot for ASB17 Gene

Publications for ASB17 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene. (PMID: 15204681) Guo J.H. … Dai L. (Arch. Androl. 2004) 3 23
  4. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ASB17 Gene

Sources for ASB17 Gene

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