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ASB17 Gene(Protein Coding)

Ankyrin Repeat And SOCS Box Containing 17

GCID:
GC01M075918
GIFtS:
44
Genes Participants
UDN Logo

Aliases for ASB17 Gene

Aliases for ASB17 Gene

  • Ankyrin Repeat And SOCS Box Containing 17 2 3 5
  • Asb-17 3 4
  • Ankyrin Repeat And SOCS Box-Containing 17 2
  • Ankyrin Repeat And SOCS Box Protein 17 3

External Ids for ASB17 Gene

Previous GeneCards Identifiers for ASB17 Gene

  • GC01M076504
  • GC01M075319
  • GC01M075800
  • GC01M075807
  • GC01M076096
  • GC01M076157
  • GC01M076384
  • GC01M074514

Summaries for ASB17 Gene

GeneCards Summary for ASB17 Gene

ASB17 (Ankyrin Repeat And SOCS Box Containing 17) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

UniProtKB/Swiss-Prot for ASB17 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB17 Gene

Genomics for ASB17 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ASB17 Gene

Enhancers for ASB17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G076002 0.3 FANTOM5 8.1 -70.5 -70510 0.2 ST6GALNAC3 SLC44A5 ASB17 MSH4 LOC105378806 ENSG00000230027
GH01G075909 0.6 ENCODE 0.3 +23.6 23583 0.2 CTCF ZNF654 TRIM22 SMC3 PRDM10 RAD21 TRIM28 GC01P075906 ASB17
GH01G075908 0.5 ENCODE 0.3 +23.4 23403 0.2 CTCF SMC3 TRIM22 PRDM10 TRIM28 GC01P075906 ASB17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB17 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ASB17 gene promoter:

Genomic Location for ASB17 Gene

Chromosome:
1
Start:
75,918,873 bp from pter
End:
75,932,433 bp from pter
Size:
13,561 bases
Orientation:
Minus strand

Genomic View for ASB17 Gene

Genes around ASB17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB17 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ASB17 Gene

Proteins for ASB17 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ASB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXJ9-ASB17_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 17
    Protein Accession:
    Q8WXJ9
    Secondary Accessions:
    • B1APB8
    • Q8N0X5

    Protein attributes for ASB17 Gene

    Size:
    295 amino acids
    Molecular mass:
    34282 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASB17 Gene

Protein Expression for ASB17 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ASB17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB17 Gene

Domains & Families for ASB17 Gene

Gene Families for ASB17 Gene

HGNC:

Protein Domains for ASB17 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ASB17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXJ9

UniProtKB/Swiss-Prot:

ASB17_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB17: view

Function for ASB17 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ASB17 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with ASB17: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB17 Gene

Localization for ASB17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB17 gene
Compartment Confidence
mitochondrion 2
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ASB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASB17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB17 Gene

Pathways & Interactions for ASB17 Gene

genes like me logo Genes that share pathways with ASB17: view

UniProtKB/Swiss-Prot Q8WXJ9-ASB17_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB17: view

No data available for SIGNOR curated interactions for ASB17 Gene

Drugs & Compounds for ASB17 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ASB17 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ASB17 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB17 Gene

Ankyrin repeat and SOCS box containing 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB17 Gene

No ASD Table

Relevant External Links for ASB17 Gene

GeneLoc Exon Structure for
ASB17
ECgene alternative splicing isoforms for
ASB17

Expression for ASB17 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB17 Gene

mRNA expression in normal human tissues for ASB17 Gene
mRNA expression by BioGPS for ASB17 GenemRNA expression by GTEx for ASB17 Gene

mRNA differential expression in normal tissues according to GTEx for ASB17 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for ASB17 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB17 Gene



Protein tissue co-expression partners for ASB17 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB17 Gene:

ASB17

SOURCE GeneReport for Unigene cluster for ASB17 Gene:

Hs.125423
genes like me logo Genes that share expression patterns with ASB17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB17 Gene

Orthologs for ASB17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ASB17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ASB17 34 35
  • 99.77 (n)
dog
(Canis familiaris)
 Mammalia ASB17 34 35
  • 91.16 (n)
cow
(Bos Taurus)
 Mammalia ASB17 34 35
  • 90.14 (n)
rat
(Rattus norvegicus)
 Mammalia Asb17 34
  • 85.37 (n)
mouse
(Mus musculus)
 Mammalia Asb17 34 16 35
  • 84.69 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia ASB17 35
  • 79 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia ASB17 35
  • 70 (a)
 OneToOne
Species where no ortholog for ASB17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ASB17 Gene

ENSEMBL:
Gene Tree for ASB17 (if available)
TreeFam:
Gene Tree for ASB17 (if available)

Paralogs for ASB17 Gene

No data available for Paralogs for ASB17 Gene

Variants for ASB17 Gene

Sequence variations from dbSNP and Humsavar for ASB17 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000179627 -- 75,933,301(+) GATCT(C/T)GGCTT intron-variant, upstream-variant-2KB
rs1000198562 -- 75,924,100(+) CCAGA(A/G)ACTAC intron-variant
rs1000432580 -- 75,931,616(+) GTGTC(-/TTTG)TTTAG intron-variant
rs1000675943 -- 75,923,735(+) GCATG(A/G)TATAA intron-variant
rs1000943569 -- 75,936,495(+) ATAAA(A/T)TTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB17 Gene

Variant ID Type Subtype PubMed ID
esv2605515 CNV insertion 19546169
esv3304877 CNV mobile element insertion 20981092
esv3401353 CNV insertion 20981092
nsv1004669 CNV loss 25217958

Variation tolerance for ASB17 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.23; 90.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB17 Gene

Disorders for ASB17 Gene

Relevant External Links for ASB17

Genetic Association Database (GAD)
ASB17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB17

No disorders were found for ASB17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB17 Gene

Publications for ASB17 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene. (PMID: 15204681) Guo J.H. … Dai L. (Arch. Androl. 2004) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3 64

Products for ASB17 Gene

Sources for ASB17 Gene

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