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ASB16-AS1 Gene

RNA gene   GIFtS: 28
GCID: GC17M042254

ASB16 Antisense RNA 1

(Previous name: chromosome 17 open reading frame 65)
(Previous symbol: C17orf65)
  See ASB16-AS1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): antisense

Quality score for this RNA gene is 3

Aliases
ASB16 Antisense RNA 11 2 3
C17orf651 2 3
Chromosome 17 Open Reading Frame 651
ASB16 Antisense Gene Protein 13

External Ids:    HGNC: 254421   Entrez Gene: 3392012   Ensembl: ENSG000002670807   UniProtKB: Q495Z43   
ORGUL members:         

Export aliases for ASB16-AS1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ASB16-AS1 Gene:
ASB16-AS1 (ASB16 antisense RNA 1) is an RNA gene, and is affiliated with the antisense RNA class. Diseases associated with ASB16-AS1 include intrahepatic cholangiocarcinoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ASB16-AS1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB16-AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

ASB16-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB16-AS1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M042254:  view genomic region     (about GC identifiers)

Start:
42,253,341 bp from pter      End:
42,264,085 bp from pter
Size:
10,745 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ASAS1_HUMAN, Q495Z4 (See protein sequence)
Recommended Name: Putative uncharacterized protein ASB16-AS1  
Size: 193 amino acids; 20099 Da
Caution: Product of a dubious gene prediction
Secondary accessions: Q495Z5 Q495Z6

Explore the universe of human proteins at neXtProt for ASB16-AS1: NX_Q495Z4

Explore proteomics data for ASB16-AS1 at MOPED


See ASB16-AS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q495Z4


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ASB16-AS1

miRNA
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miRTarBase miRNAs that target ASB16-AS1:
hsa-mir-378a-3p (MIRT043916)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASB16-AS1
Interactions:

    Search GeneGlobe Interaction Network for ASB16-AS1

1 Interacting protein for ASB16-AS1 (Q495Z43) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SHBGP042783I2D: score=2 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ASB16-AS1 (ASAS1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ASB16-AS1 gene: 
NM_178542.3  

Unigene Cluster for ASB16-AS1:

ASB16 antisense RNA 1
Hs.656564  [show with all ESTs]
Unigene Representative Sequence: NR_049729
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000585457(antisense) ENST00000591166(antisense) ENST00000588785(antisense) ENST00000592897(antisense)
miRNA
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Additional mRNA sequence: 

AK055685.1 AL833953.1 BC009448.1 BC100964.2 BC100965.1 BC100966.1 BC100967.1 NR_049729.1 
NR_049730.1 

6 DOTS entries:

DT.40116535  DT.100698061  DT.100698060  DT.97779280  DT.120902737  DT.95153908 

Selected AceView cDNA sequences (see all 60):

CB151608 BE543127 BQ883658 AA291700 F18412 BX447380 BX459186 BE222270 
BE222081 H94230 AA365276 BU176211 BX283685 R40998 AL833953 R11040 
NM_178542 BF569692 BE336766 BX105287 AA291630 BM450860 H93001 BQ647438 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for ASB16-AS1:none

ASB16-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ASB16-AS1 Expression
About this image

ASB16-AS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ASB16-AS1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.656564
    Custom PCR Arrays for ASB16-AS1
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB16-AS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for ASB16-AS1 (if available)
TreeFam Gene Tree for ASB16-AS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ASB16-AS1 gene
1 SIMAP similar gene for ASB16-AS1 using alignment to 1 protein entry:     ASAS1_HUMAN:
C17orf65

Find genes that share paralogs with ASB16-AS1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ASB16-AS1 (see all 83)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs350679051,2
C--42257018(+) AAAAA-/AGTCTT 2 -- int12Minor allele frequency- A:0.25NA 4
rs7574311,2
C--42257134(-) TGGCCG/AGACGG 2 -- int12Minor allele frequency- A:0.00NA 4
rs354079581,2
C--42257196(+) GGAGCC/TGGGAC 2 -- int11Minor allele frequency- T:0.00NA 2
rs1861669111,2
--42258931(+) GTGTCA/CACTCA 2 -- int10--------
rs116561041,2
C,H--42258965(+) AAAAAT/AGCCAA 2 -- int13Minor allele frequency- A:0.20WA NA CSA 5
rs1895864341,2
--42259072(+) GACCAC/TGCTAT 2 -- nc-transcript-variant0--------
rs733161561,2
C,F--42259160(+) GAACAG/CAGCCT 2 -- int12Minor allele frequency- C:0.06WA 120
rs1435366871,2
--42259163(+) CAGAGC/TCTCTA 2 -- int10--------
rs1808162551,2
--42259318(+) GAATAC/TTCTTC 2 -- int10--------
rs1867401921,2
--42259412(+) CTTATG/TTAAGT 2 -- int10--------

HapMap Linkage Disequilibrium report for ASB16-AS1 (42253341 - 42264085 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ASB16-AS1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ASB16-AS1
DNA2.0 Custom Variant and Variant Library Synthesis for ASB16-AS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for ASB16-AS1:    
About MalaCards
intrahepatic cholangiocarcinoma


Find genes that share disorders with ASB16-AS1           About GenesLikeMe


Export disorders for ASB16-AS1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ASB16-AS1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ASB16-AS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
  4. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PubMed id 15862967)1 Pope S.N. and Lee I.R. (J. Steroid Biochem. Mol. Biol. 2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 339201 HGNC: 25442 AceView: DKFZp762C2414 Ensembl:ENSG00000267080 euGenes: HUgn339201
ECgene: ASB16-AS1 H-InvDB: ASB16-AS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ASB16-AS1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ASB16-AS1 gene:
Search GeneIP for patents involving ASB16-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 antibodies-online peptides for ASB16-AS1
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