ASB16 Gene
protein-coding GIFtS: 50
GCID: GC17P042258
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|
ankyrin repeat and SOCS box containing 16(Previous name: ankyrin repeat and SOCS box-containing 16 )
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Aliases
for ASB16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ankyrin Repeat And SOCS Box Containing 161 2 | | Ankyrin Repeat And SOCS Box-Containing 161 2 | | FLJ301651 | | Ankyrin Repeat And SOCS Box Protein 162 | | Ankyrin Repeat And SOCS Box-Containing Protein 162 | | ASB-163 |
Export aliases for ASB16 gene to outside databasesPrevious GC identifers: GC17M041995 GC17P044425 GC17P042723 GC17P039603 GC17P038012 |
Summaries
for ASB16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ASB16:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins.They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokinesignalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them fordegradation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ASB16_HUMAN, Q96NS5Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity)
|
Genomic Views
for ASB16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASB16 gene promoter:
AML1a Pax-5 RelA AP-4 Max PPAR-gamma1 HSF2 PPAR-gamma2 ZID c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASB16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31ASB16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P042258: view genomic region
(about GC identifiers)
Start:
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42,247,815 bp from pter |
End:
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42,256,451 bp from pter |
Size:
|
8,637 bases |
Orientation:
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plus strand |
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Proteins
for ASB16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASB16_HUMAN, Q96NS5 (See
protein sequence)Recommended Name: Ankyrin repeat and SOCS box protein 16 Size: 453 amino acids; 49637 Da
Secondary accessions: B2RBC0 Q8WXK0Explore the universe of human proteins at neXtProt for ASB16: NX_Q96NS5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96NS5
ASB16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_543139.4
ENSEMBL proteins: ENSP00000466349 ENSP00000293414 ENSP00000466033 Reactome Protein details: Q96NS5
Human Recombinant Protein Products for ASB16:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
ASB16 for ontologies About GeneDecksing
ASB16 Antibody Products:
Assay Products for ASB16: |
Protein
Domains /
Families
for ASB16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASB16 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96NS5ProtoNet protein and cluster: Q96NS5 1 Blocks protein family: IPB001496 SOCS protein
UniProtKB/Swiss-Prot: ASB16_HUMAN, Q96NS5Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3ubiquitin-protein ligase complexes (By similarity)Similarity: Contains 7 ANK repeatsSimilarity: Contains 1 SOCS box domain |
Function
for ASB16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ASB16_HUMAN, Q96NS5Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
ASB16 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for ASB16:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ASB16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB16 |
|
Pathways & Interactions
for ASB16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for ASB16
UniProtKB/Swiss-Prot: ASB16_HUMAN, Q96NS5Pathway: Protein modification; protein ubiquitination
ASB16 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASB16
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for ASB16 (Q96NS51, 3 ENSP000002934144) via UniProtKB, MINT, STRING, and/or I2D
About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- | | GO:0035556 | intracellular signal transduction |
IEA | -- |
ASB16 for ontologies About GeneDecksing
|
Drugs & Compounds
for ASB16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ASB16
Search CenterWatch for drugs/clinical trials and news about ASB16
|
Transcripts
for ASB16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASB16 gene: NM_080863.4 Unigene Cluster for ASB16: Ankyrin repeat and SOCS box containing 16 Hs.534517 [show with all ESTs]Unigene Representative Sequence: AK0547273 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000591700 ENST00000293414(uc002ifl.1 uc002ifm.1) ENST00000589618
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ASB16 (NM_080863) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASB16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB16 |
Additional cDNA sequence: AF403034.1 AK054727.1 AK314595.1 AY557346.1 BC075088.2 BC118584.1 BC118585.1 3 DOTS entries: DT.92031363 DT.40199974 DT.97822463 11 AceView cDNA sequences: NM_080863 AK054727 AY557346 AF403034 BC075088 BF964503 BF736274 BF926260 BX404766 F01109 BQ361147
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ASB16 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ASB16
|
Expression
for ASB16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASB16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAGAACCA
About this image
See ASB16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASB16
SOURCE GeneReport for Unigene cluster: Hs.534517
SABiosciences Custom PCR Arrays for ASB16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASB16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB16 |
Orthologs
for ASB16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ASB16 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for ASB16 (if available)
TreeFam Gene Tree for ASB16 (if available) |
Paralogs
for ASB16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ASB16 gene
- ASB182 ASB42 ASB102
7 SIMAP similar genes for ASB16 using alignment to 5 protein entries: ASB16_HUMAN (see all proteins):ASB18 ASB8 ANKRD46 ASB4 IkBa ASB10
HACE1
ASB16 for paralogs About GeneDecksing
|
Genomic Variants
for ASB16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASB16 (42247815 - 42256451 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ASB16
1 CNV: 5008 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB16 |
|
Disorders
/ Diseases
for ASB16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 ASB16 for disorders About MalaCards
ASB16 for disorders About GeneDecksing
OMIM gene information: 615056
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: ASB16 (1 document)
Export disorders for ASB16 gene to outside databases
|
Publications
for ASB16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASB16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASB16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (2002)
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1 Kohroki J.... Masuho Y. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ASB16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ASB16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASB16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASB16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASB16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ASB16 gene:
Search GeneIP for patents involving ASB16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASB16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB16 | | | OriGene Protein Over-expression Lysate for ASB16 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ASB16 | | OriGene Custom Protein Services for ASB16 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASB16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB16 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ASB16 |
| |  |  |  |  | | | | |
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 |
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 | | | ASB16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB16 |
|  |  |  |  | | | | ThermoFisher Antibodies for ASB16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB16 |
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