Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ASB15 Gene

protein-coding   GIFtS: 49
GCID: GC07P123207

Ankyrin Repeat And SOCS Box Containing 15

(Previous name: ankyrin repeat and SOCS box-containing 15)
  Search for ASB15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ankyrin Repeat And SOCS Box Containing 151 2
Ankyrin Repeat And SOCS Box-Containing 151
Ankyrin Repeat And SOCS Box Protein 152
ASB-153

External Ids:    HGNC: 197671   Entrez Gene: 1426852   Ensembl: ENSG000001468097   UniProtKB: Q8WXK13   

Export aliases for ASB15 gene to outside databases

Previous GC identifers: GC07P121742 GC07P122805 GC07P122809 GC07P122803 GC07P122835 GC07P123036 GC07P117612


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ASB15 Gene:
This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this
superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and
signal transduction pathways. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Mar 2014)

GeneCards Summary for ASB15 Gene:
ASB15 (ankyrin repeat and SOCS box containing 15) is a protein-coding gene. An important paralog of this gene is ASB3.

UniProtKB/Swiss-Prot: ASB15_HUMAN, Q8WXK1
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASB15 gene promoter:
         Max1   TBP   HNF-3beta   C/EBPalpha   MEF-2A   S8   COMP1   aMEF-2   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ASB15 promoter sequence
   Search Chromatin IP Primers for ASB15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.31   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.31

ASB15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB15 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P123207:  view genomic region     (about GC identifiers)

Start:
123,207,064 bp from pter      End:
123,277,951 bp from pter
Size:
70,888 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 122,637,747-122,666,569     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ASB15_HUMAN, Q8WXK1 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 15  
Size: 588 amino acids; 65799 Da
Secondary accessions: Q3ZCP3 Q3ZCP5 Q68D37

Explore the universe of human proteins at neXtProt for ASB15: NX_Q8WXK1

Explore proteomics data for ASB15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ASB15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001277187.1  NP_563616.3  

    ENSEMBL proteins: 
     ENSP00000397655   ENSP00000390963   ENSP00000406163   ENSP00000416433   ENSP00000401166  
     ENSP00000438643   ENSP00000275699  
    Reactome Protein details: Q8WXK1

    ASB15 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ASB15
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ASB15
    GenScript Custom Purified and Recombinant Proteins Services for ASB15
    Novus Biologicals ASB15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ASB15

    ASB15 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ASB15
    Novus Biologicals ASB15 Antibody
    Abcam antibodies for ASB15
    Cloud-Clone Corp. Antibodies for ASB15
    ThermoFisher Antibodies for ASB15
    Search LSBio for Antibodies for ASB15

    ASB15 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ASB15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ASB15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ASB15
    Cloud-Clone Corp. CLIAs for ASB15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR001496 SOCS_C
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q8WXK1

    ProtoNet protein and cluster: Q8WXK1

    2 Blocks protein domains:
    IPB001496 SOCS protein
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ASB15_HUMAN, Q8WXK1
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin-protein ligase complexes (By similarity)
    Similarity: Contains 9 ANK repeats
    Similarity: Contains 1 SOCS box domain


    ASB15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASB15_HUMAN, Q8WXK1
    Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    ASB15 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ASB15:
     Decreased viability with pacli 

         1 MGI phenotypic allele for Asb15 (no phenotypes)

    ASB15 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASB15
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASB15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASB15
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASB15

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ASB15 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ASB15:
    hsa-miR-1321 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-3162-5p
    SwitchGear 3'UTR luciferase reporter plasmidASB15 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ASB15
    Predesigned siRNA for gene silencing in human, mouse, rat ASB15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ASB15

    Clone
    Products:
         
    OriGene clones in human, mouse for ASB15 (see all 5)
    OriGene ORF clones in mouse, rat for ASB15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ASB15 (NM_080928)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB15

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ASB15
    Browse ESI BIO Cell Lines and PureStem Progenitors for ASB15 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ASB15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ASB15
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: ASB15_HUMAN, Q8WXK1
    Pathway: Protein modification; protein ubiquitination


    ASB15 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASB15
    Interactions:

        Search GeneGlobe Interaction Network for ASB15

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ASB15 (ENSP000002756994) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB39ENSP000003001014STRING: ENSP00000300101
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    ASB15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASB15



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ASB15 gene (2 alternative transcripts): 
    NM_001290258.1  NM_080928.4  

    Unigene Cluster for ASB15:

    Ankyrin repeat and SOCS box containing 15
    Hs.83916  [show with all ESTs]
    Unigene Representative Sequence: AK125360
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451558(uc003vkv.1) ENST00000434204 ENST00000437535 ENST00000451215(uc003vku.1)
    ENST00000447789 ENST00000540573 ENST00000275699(uc003vkw.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ASB15 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate ASB15:
    hsa-miR-1321 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-3162-5p
    SwitchGear 3'UTR luciferase reporter plasmidASB15 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ASB15
    Predesigned siRNA for gene silencing in human, mouse, rat ASB15
    Clone
    Products:
         
    OriGene clones in human, mouse for ASB15 (see all 5)
    OriGene ORF clones in mouse, rat for ASB15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ASB15 (NM_080928)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB15
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ASB15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB15
      QuantiTect SYBR Green Assays in human, mouse, rat ASB15
      QuantiFast Probe-based Assays in human, mouse, rat ASB15

    Additional mRNA sequence: 

    AF403033.1 AF428257.1 AK125360.1 BC100874.2 BC100875.2 BC100876.1 BC100877.2 CR749595.1 

    3 DOTS entries:

    DT.97817003  DT.121079771  DT.121079733 

    5 AceView cDNA sequences:

    AF403033 NM_080928 AF428257 AK125360 CR749595 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ASB15 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
    SP1:              -                 -     -     -                                                                                 
    SP2:                                            -                                                                                 
    SP3:                                                                                                                              
    SP4:                                -     -     -                                                                                 
    SP5:              -           -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for ASB15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ASB15 expression in normal human tissues (normalized intensities)      ASB15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACATCTT
    ASB15 Expression
    About this image


    ASB15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
    ASB15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASB15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83916
        Custom PCR Arrays for ASB15
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ASB15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB15
    QuantiTect SYBR Green Assays in human, mouse, rat ASB15
    QuantiFast Probe-based Assays in human, mouse, rat ASB15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ASB15 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asb151 , 5 ankyrin repeat and SOCS box-containing 151, 5 85.71(n)1
    88.51(a)1
      6 (11.28 cM)5
    789101  NM_080847.31  NP_543123.21 
     245281445 
    chicken
    (Gallus gallus)
    Aves ASB151 ankyrin repeat and SOCS box containing 15 74.91(n)
    76.11(a)
      417752  XM_004937524.1  XP_004937581.1 
    lizard
    (Anolis carolinensis)
    Reptilia ASB156
    ankyrin repeat and SOCS box containing 15
    70(a)
    1 ↔ 1
    5(67475739-67490053)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia asb151 ankyrin repeat and SOCS box containing 15 68.9(n)
    68.61(a)
      100486500  XM_002941830.2  XP_002941876.1 
    zebrafish
    (Danio rerio)
    Actinopterygii asb15b1 ankyrin repeat and SOCS box containing 15b 57.41(n)
    55.21(a)
      568579  NM_001039890.1  NP_001034979.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M60.76
    Protein M60.7 (M60.7) mRNA, complete cds
    23(a)
    1 → many
    X(8258486-8261175) WBGene00019782


    ENSEMBL Gene Tree for ASB15 (if available)
    TreeFam Gene Tree for ASB15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ASB15 gene
    ASB32  ASB22  ASB142  
    3 SIMAP similar genes for ASB15 using alignment to 2 protein entries:     ASB15_HUMAN (see all proteins):
    ASB14    ASB2    ANKDD1A

    ASB15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ASB15 (see all 683)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446131711,2
    --117609841(+) ATTTTA/TAAATT 1 -- us2k10--------
    rs1908470951,2
    --123247190(+) ATGTCA/GAATTA 1 -- us2k10--------
    rs1385436491,2
    --123247392(+) TATTCC/TATTTT 1 -- us2k10--------
    rs1418311211,2
    --123247438(+) TTTGGA/GACATT 1 -- us2k10--------
    rs771196631,2
    C,F--123247450(+) ATGTTG/TTTTCT 1 -- us2k11Minor allele frequency- T:0.11WA 118
    rs1498627401,2
    C--123247599(+) GAAGT-/GGCATG 1 -- us2k10--------
    rs1164577931,2
    C,F--123247692(+) CCTACC/TACCAC 1 -- us2k11Minor allele frequency- T:0.11WA 118
    rs801503661,2
    C,F--123247855(+) GACATA/GGAATT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs802681921,2
    C,F--123248090(+) TGTTAT/CAATTA 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs734393431,2
    C,F--123248187(+) CTCATA/GCTAAT 1 -- us2k12Minor allele frequency- G:0.06WA 120

    HapMap Linkage Disequilibrium report for ASB15 (123207064 - 123277951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ASB15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508479CNV Loss20534489
    nsv889125CNV Gain21882294
    nsv831116CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASB15
    DNA2.0 Custom Variant and Variant Library Synthesis for ASB15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ASB15 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ASB15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
    3. Identification and characterization of ankyrin repeat and SOCS box-containing gene ASB15 in silico. (PubMed id 16012773)1, 9 Yoshida K. (Int. J. Mol. Med. 2005)
    4. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)1 Szafranski K....Platzer M. (Genome Biol. 2007)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1 Kohroki J.... Masuho Y. (FEBS Lett. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 142685 HGNC: 19767 AceView: ASB15 Ensembl:ENSG00000146809 euGenes: HUgn142685
    ECgene: ASB15 H-InvDB: ASB15

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ASB15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ASB15 gene:
    Search GeneIP for patents involving ASB15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ASB15  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ASB15  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ASB15  
     OriGene qSTAR qPCR primer pairs in human, mouse for ASB15   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ASB15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ASB15   OriGene Custom Protein Services for ASB15  

     
     
     Block miRNA regulation of human, mouse, rat ASB15 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ASB15
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB15 Predesigned siRNA for gene silencing in human, mouse, rat ASB15
     QuantiFast Probe-based Assays in human, mouse, rat ASB15 QuantiTect SYBR Green Assays in human, mouse, rat ASB15
     Custom PCR Arrays for ASB15 Search Chromatin IP Primers for ASB15
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB15  Search GeneGlobe Interaction Network for ASB15
     Regulatory tfbs in ASB15 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ASB15 GenScript cDNA clones with any tag delivered in your preferred vector for ASB15
     GenScript Custom Assay Services for ASB15 GenScript Custom overexpressing Cell Line Services for ASB15
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ASB15
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ASB15 antibodies
     ASB15 lysates
     Antibodies for ASB15
     See all of Abcam's Antibodies, Kits and Proteins for ASB15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ASB15
     Antibodies for ASB15
     ELISAs for ASB15
     CLIAs for ASB15



     Browse ESI BIO Cell Lines and PureStem Progenitors for ASB15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB15
     SwitchGear 3'UTR luciferase reporter plasmids for ASB15
     SwitchGear Promoter luciferase reporter plasmids for ASB15
     ThermoFisher Antibodies for ASB15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB15
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASB15
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASB15
     Search LSBio for Antibodies for ASB15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ASB15 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4