Aliases for ASB15 Gene
Aliases for ASB15 Gene
External Ids for ASB15 Gene
- HGNC: 19767
- Entrez Gene: 142685
- Ensembl: ENSG00000146809
- UniProtKB: Q8WXK1
Previous GeneCards Identifiers for ASB15 Gene
- GC07P121742
- GC07P122805
- GC07P122809
- GC07P122803
- GC07P122835
- GC07P123036
- GC07P123207
- GC07P117612
Summaries for ASB15 Gene
-
This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
GeneCards Summary for ASB15 Gene
ASB15 (Ankyrin Repeat And SOCS Box Containing 15) is a Protein Coding gene. Diseases associated with ASB15 include Retinitis Pigmentosa 11. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB14.
UniProtKB/Swiss-Prot for ASB15 Gene
-
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB15 Gene
Genomics for ASB15 Gene
Regulatory Elements for ASB15 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G123643 | 1.5 | Ensembl ENCODE dbSUPER | 10.2 | +77.1 | 77089 | 2.0 | PKNOX1 ATF1 FEZF1 ZNF2 YY1 ZNF766 GATA2 FOS DEK YY2 | ASB15 RNU6-11P ENSG00000272686 LMOD2 LOC102724555 |
| GH07G123608 | 1.2 | ENCODE dbSUPER | 10.8 | +42.5 | 42518 | 1.1 | HDAC1 PKNOX1 ATF1 NFRKB ZNF766 ELK1 CEBPB ZEB2 ZNF592 POLR2H | LMOD2 ASB15 IQUB NDUFA5 LOC102724555 |
| GH07G123537 | 1.2 | Ensembl ENCODE | 10.6 | -27.8 | -27800 | 3.4 | PKNOX1 ATF1 ARNT TCF12 GATA2 FOS JUNB NCOA1 SMARCB1 ZNF592 | ASB15 NDUFA5 IQUB |
| GH07G123645 | 0.9 | ENCODE dbSUPER | 10.2 | +78.6 | 78582 | 0.8 | CTCF RBBP5 CHD7 RAD21 NR2F2 YY1 JUND ZNF701 POU5F1 HNF4A | LOC102724555 WASL ASB15 RNU6-11P LMOD2 |
| GH07G123602 | 0.8 | dbSUPER | 11.1 | +35.9 | 35892 | 0.4 | PKNOX1 ESRRA BACH1 ZMYM3 GATA3 CTBP1 ZNF316 FOS NFE2 RCOR1 | LOC102724555 LMOD2 ASB15 IQUB NDUFA5 |
- Transcription factor binding sites by QIAGEN in the ASB15 gene promoter:
Regulatory Element Products
Genomic Location for ASB15 Gene
- Chromosome:
- 7
- Start:
- 123,566,999 bp from pter
- End:
- 123,639,481 bp from pter
- Size:
- 72,483 bases
- Orientation:
- Plus strand
Genomic View for ASB15 Gene
- Cytogenetic band:
-
- 7q31.32 by Ensembl
- 7q31.32 by Entrez Gene
- 7q31.32 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASB15 Gene
Proteins for ASB15 Gene
-
Protein details for ASB15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WXK1-ASB15_HUMAN
- Recommended name:
- Ankyrin repeat and SOCS box protein 15
- Protein Accession:
- Q8WXK1
- Q3ZCP3
- Q3ZCP5
- Q68D37
Protein attributes for ASB15 Gene
- Size:
- 588 amino acids
- Molecular mass:
- 65799 Da
- Quaternary structure:
- No Data Available
Protein Expression for ASB15 Gene
Post-translational modifications for ASB15 Gene
Other Protein References for ASB15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for ASB15
Protein Products
-
OriGene Purified Proteins for ASB15
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Assay Products
- antibodies-online Kits for ASB15: See all 33
No data available for DME Specific Peptides for ASB15 Gene
Domains & Families for ASB15 Gene
Gene Families for ASB15 Gene
Protein Domains for ASB15 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASB15 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WXK1UniProtKB/Swiss-Prot:
ASB15_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Belongs to the ankyrin SOCS box (ASB) family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Family:
-
- Belongs to the ankyrin SOCS box (ASB) family.
Function for ASB15 Gene
Molecular function for ASB15 Gene
- UniProtKB/Swiss-Prot Function:
- May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IBA | -- |
| GO:0031625 | ubiquitin protein ligase binding | IBA | -- |
Phenotypes for ASB15 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB15 gene
-
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CRISPR Products
-
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-
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miRNA Products
- Search ViGene Biosciences for ASB15
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ASB15
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-
ViGene Biosciences ready-to-package AAV shRNAs for ASB15 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASB15
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ASB15
-
ViGene Biosciences adenoviral particle packaged cDNA for ASB15 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB15 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB15 Gene
Localization for ASB15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IBA | -- |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB15 Gene
Pathways & Interactions for ASB15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for ASB15 Gene
4 Reactome pathways for ASB15 Gene
UniProtKB/Swiss-Prot Q8WXK1-ASB15_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ASB15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for ASB15 Gene
Transcripts for ASB15 Gene
mRNA/cDNA for ASB15 Gene
- (5) Selected AceView cDNA sequences:
- (8) Additional mRNA sequences :
- (12) REFSEQ mRNAs :
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASB15 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ASB15
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASB15
- GenScript: Design CRISPR guide RNA sequences for ASB15
miRNA Products
- Search ViGene Biosciences for ASB15
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ASB15
- Browse OriGene Inhibitory RNA Products For ASB15
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB15 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASB15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB15
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for ASB15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Kidney (Urinary System)
- Podocytes Podocyte Layer
-
Epithelial Cells
- Podocytes Podocyte Layer
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for ASB15 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB15 Gene
NURSA nuclear receptor signaling pathways regulating expression of ASB15 Gene:
ASB15SOURCE GeneReport for Unigene cluster for ASB15 Gene:
Hs.83916Evidence on tissue expression from TISSUES for ASB15 Gene
- Liver(4.2)
- Muscle(2.5)
Primer Products
-
OriGene qPCR primer pairs for ASB15
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB15 Gene
Orthologs for ASB15 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASB15 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ASB15 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASB15 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | ASB15 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Asb15 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asb15 34 |
|
||
| chicken (Gallus gallus) |
Aves | ASB15 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ASB15 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | asb15 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | asb15b 34 35 |
|
||
| asb15a 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | M60.7 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ASB15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ASB15 Gene
(3) SIMAP similar genes for ASB15 Gene using alignment to 2 proteins:
Variants for ASB15 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000037413 | -- | 123,583,351(+) | GAAGT(A/G)GGAAC | intron-variant | |
| rs1000061682 | -- | 123,599,846(+) | AACTA(G/T)TCCTT | intron-variant, upstream-variant-2KB | |
| rs1000093336 | -- | 123,617,173(+) | GATGA(G/T)GTTAA | intron-variant, upstream-variant-2KB | |
| rs1000115003 | -- | 123,599,508(+) | TTTTT(-/C)AGGAA | intron-variant | |
| rs1000176521 | -- | 123,625,655(+) | GTGAC(A/G)CTGCC | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3614858 | CNV | loss | 21293372 |
| esv3891198 | CNV | gain | 25118596 |
| nsv508479 | CNV | deletion | 20534489 |
| nsv831116 | CNV | gain+loss | 17160897 |
Relevant External Links for ASB15 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASB15
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB15 Gene
Disorders for ASB15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| retinitis pigmentosa 11 |
|
|
Relevant External Links for ASB15
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ASB15
No data available for UniProtKB/Swiss-Prot and Genatlas for ASB15 Gene
Publications for ASB15 Gene
- Identification and characterization of ankyrin repeat and SOCS box-containing gene ASB15 in silico. (PMID: 16012773) Yoshida K. (Int. J. Mol. Med. 2005) 3 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
- Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3 64
- The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
Products for ASB15 Gene
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- Novus Biologicals lysates for ASB15
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for ASB15 gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for ASB15
- VectorBuilder custom plasmid, inducible vectors for ASB15
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB15
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASB15 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
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- (125) UMLS
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
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- (140) FANTOM5
- (141) ENCODE
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- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




