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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ASB15 Gene

protein-coding GIFtS: 48
GCID: GC07P123207

ankyrin repeat and SOCS box containing 15

(Previous name: ankyrin repeat and SOCS box-containing 15 )

Search for ASB15
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ankyrin Repeat And SOCS Box Containing 15¹ ²
Ankyrin Repeat And SOCS Box-Containing 15¹ ²
ASB-15² ³
FLJ43370¹
Ankyrin Repeat And SOCS Box Protein 15²

External Ids:	HGNC: 19767¹	Entrez Gene: 142685²	Ensembl: ENSG00000146809⁷	UniProtKB: Q8WXK1³

Export aliases for ASB15 gene to outside databases

Previous GC identifers: GC07P121742 GC07P122805 GC07P122809 GC07P122803 GC07P122835 GC07P123036 GC07P117612

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ASB15_HUMAN, Q8WXK1

Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3

ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target

proteins (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ASB15 gene promoter:
Max1 TBP HNF-3beta C/EBPalpha MEF-2A S8 COMP1 aMEF-2 RSRFC4 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ASB15 promoter sequence

Search SABiosciences Chromatin IP Primers for ASB15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.31 Ensembl cytogenetic band: 7q31.32 HGNC cytogenetic band: 7q31.31

ASB15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB15 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P123207: view genomic region (about GC identifiers)

Start:	123,207,064 bp from pter	End:	123,277,951 bp from pter
Size:	70,888 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 122,637,747-122,666,569

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ASB15_HUMAN, Q8WXK1 (See protein sequence)

Recommended Name: Ankyrin repeat and SOCS box protein 15

Size: 588 amino acids; 65799 Da

Secondary accessions: Q3ZCP3 Q3ZCP5 Q68D37

Explore the universe of human proteins at neXtProt for ASB15: NX_Q8WXK1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WXK1

ASB15 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_563616.3

ENSEMBL proteins:

ENSP00000397655 ENSP00000390963 ENSP00000406163 ENSP00000416433 ENSP00000401166

ENSP00000438643 ENSP00000275699

Reactome Protein details: Q8WXK1
Human Recombinant Protein Products:

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	Novus Biologicals ASB15 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ASB15

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--

ASB15 for ontologies About GeneDecksing

ASB15 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals ASB15 Antibody
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	Uscn Antibodies for ASB15
	ThermoFisher Antibodies for ASB15

Assay Products for ASB15:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for ASB15
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ASB15

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ASB15 for domains About GeneDecksing

3 InterPro domains/families:

IPR001496 SOCS_C

IPR020683 Ankyrin_rpt-contain_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q8WXK1

ProtoNet protein and cluster: Q8WXK1

2 Blocks protein families:

IPB001496 SOCS protein

IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: ASB15_HUMAN, Q8WXK1

Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3

ubiquitin-protein ligase complexes (By similarity)

Similarity: Contains 9 ANK repeats

Similarity: Contains 1 SOCS box domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ASB15_HUMAN, Q8WXK1

Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3

ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target

proteins (By similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB15
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB15:
		hsa-miR-1321 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-3162-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ASB15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB15 (see all 4) OriGene shRNA RFP: ASB15 OriGene siRNA: ASB15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB15

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ASB15

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB15 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB15 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ASB15 (NM_080928)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB15

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ASB15
		Search LifeMap BioReagents cell lines for ASB15

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB15

1 GenomeRNAi human phenotype for ASB15:

Decreased viability with pacli

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for ASB15

	Antigen processing: Ubiquitination & Proteasome degradation
	Polyubiquitination of substrate
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

UniProtKB/Swiss-Prot: ASB15_HUMAN, Q8WXK1

Pathway: Protein modification; protein ubiquitination

ASB15 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ASB15

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016567	protein ubiquitination	IEA	--
GO:0035556	intracellular signal transduction	IEA	--

ASB15 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ASB15
Search CenterWatch for drugs/clinical trials and news about ASB15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ASB15 gene:

NM_080928.3

Unigene Cluster for ASB15:

Ankyrin repeat and SOCS box containing 15

Hs.83916 [show with all ESTs]

Unigene Representative Sequence: AK125360

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000451558(uc003vkv.1) ENST00000434204 ENST00000437535 ENST00000451215(uc003vku.1)

ENST00000447789 ENST00000540573 ENST00000275699(uc003vkw.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASB15
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate ASB15:
		hsa-miR-1321 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-3162-5p
		SwitchGear 3'UTR luciferase reporter plasmid: ASB15 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB15 (see all 4) OriGene shRNA RFP: ASB15 OriGene siRNA: ASB15
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB15

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB15 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB15 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ASB15 (NM_080928)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB15
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB15

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB15 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ASB15
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB15

Additional cDNA sequence:

AF403033.1 AF428257.1 AK125360.1 BC100874.2 BC100875.2 BC100876.1 BC100877.2 CR749595.1

3 DOTS entries:

DT.97817003 DT.121079771 DT.121079733

5 AceView cDNA sequences:

AF428257 AF403033 NM_080928 CR749595 AK125360

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ASB15 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16
SP1:					-						-		-		-
SP2:															-
SP3:
SP4:											-		-		-
SP5:					-				-		-		-		-

ECgene alternative splicing isoforms for ASB15

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ASB15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGACATCTT

About this image

ASB15 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Podocyte Layer

Podocytes

Kidney

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ASB15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASB15

SOURCE GeneReport for Unigene cluster: Hs.83916

SABiosciences Custom PCR Arrays for ASB15

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB15 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ASB15
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB15
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB15

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB15

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASB15 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ASB15¹	ankyrin repeat and SOCS box containing 15	74.91(n) 76.11(a)		417752 XM_415996.2 XP_415996.2
lizard (Anolis carolinensis)	Reptilia	ASB15⁶	--	75(a)	1 ↔ 1	5(67476484-67490020)
zebrafish (Danio rerio)	Actinopterygii	asb15b¹	ankyrin repeat and SOCS box containing 15b	57.52(n) 55.38(a)		568579 NM_001039890.1 NP_001034979.1
honey bee (Apis mellifera)	Insecta	-- --	--	22(a) 19(a)	possible ortholog possible ortholog	GroupUn.2402(3656-4465) GroupUn.141(13787-29536)
worm (Caenorhabditis elegans)	Secernentea	M60.7⁶	Protein M60.7	16(a)	possible ortholog	X(8258435-8261124)
thale cress (Arabidopsis thaliana)	eudicotyledons	TPR10⁶	ankyrin repeat family protein	11(a)	1 → many	3(1276668-1281118)
rice (Oryza sativa)	Liliopsida	-- -- (see all 30)	ankyrin, putative, expressed (see all 30)	19(a) 19(a) (see all 30)	many ↔ many many ↔ many (see all 30)	2(17223153-17227085) 2(17271383-17284330)

ENSEMBL Gene Tree for ASB15 (if available)
TreeFam Gene Tree for ASB15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ASB15 gene

ASB3² ASB2² ASB14²

3 SIMAP similar genes for ASB15 using alignment to 2 protein entries: ASB15_HUMAN (see all proteins):

ASB14 ASB2 ANKDD1A

ASB15 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190847095^1,2		--	123247190(+)	`ATGTCA/GAATTA`	1	--	us2k¹		0	--	--	--	--
rs138543649^1,2		--	123247392(+)	`TATTCC/TATTTT`	1	--	us2k¹		0	--	--	--	--
rs141831121^1,2		--	123247438(+)	`TTTGGA/GACATT`	1	--	us2k¹		0	--	--	--	--
rs77119663^1,2	C,F,	--	123247450(+)	`ATGTTG/TTTTCT`	1	--	us2k¹		1		WA	118
rs149862740^1,2	C,	--	123247599(+)	`GAAGT-/GGCATG`	1	--	us2k¹		0	--	--	--	--
rs116457793^1,2	C,F,	--	123247692(+)	`CCTACC/TACCAC`	1	--	us2k¹		1		WA	118
rs80150366^1,2	F,	--	123247855(+)	`GACATA/GGAATT`	1	--	us2k¹		1		NA	120
rs80268192^1,2	C,F,	--	123248090(+)	`TGTTAT/CAATTA`	1	--	us2k¹		1		WA	118
rs73439343^1,2	C,	--	123248187(+)	`CTCATA/GCTAAT`	1	--	us2k¹		2		WA	120
rs143749332^1,2	C,	--	123248231(+)	`CTGGA-/GATAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ASB15 (123207064 - 123277951 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ASB15: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB15

DNA2.0 Custom Variant and Variant Library Synthesis for ASB15

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ASB15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASB15)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)^{1, 3} Kile B.T....Hilton D.J. (2002)
Identification and characterization of ankyrin repeat and SOCS box-containing gene ASB15 in silico. (PubMed id 16012773)^{1, 9} Yoshida K. (2005)
Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)¹ Szafranski K....Platzer M. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)¹ Kohroki J.... Masuho Y. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)² Hillier L.W.... Wilson R.K. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 142685	HGNC: 19767	AceView: ASB15	Ensembl:ENSG00000146809	euGenes: HUgn142685
ECgene: ASB15	H-InvDB: ASB15

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ASB15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ASB15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ASB15 gene:
Search GeneIP for patents involving ASB15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for ASB15
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB15		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB15
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASB15
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB15
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB15
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASB15
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	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB15

	GenScript Custom Purified and Recombinant Proteins Services for ASB15		GenScript cDNA clones with any tag delivered in your preferred vector for ASB15
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	Regulatory tfbs in ASB15 promoter
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ASB15 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB15

	SwitchGear 3'UTR luciferase reporter plasmids for ASB15
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ThermoFisher Antibodies for ASB15

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB15

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ASB15 gene at Home site.

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ASB15 Gene

ankyrin repeat and SOCS box containing 15

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ASB15 Gene

ankyrin repeat and SOCS box containing 15

Aliasesfor ASB15 gene

Summariesfor ASB15 gene

Genomic Viewsfor ASB15 gene

Proteinsfor ASB15 gene

Protein Domains /Familiesfor ASB15 gene

Functionfor ASB15 gene

Pathways & Interactionsfor ASB15 gene

Drugs & Compoundsfor ASB15 gene

Transcriptsfor ASB15 gene

Expression for ASB15 gene

Orthologsfor ASB15 gene

Paralogsfor ASB15 gene

Genomic Variantsfor ASB15 gene

Disorders / Diseasesfor ASB15 gene

Publicationsfor ASB15 gene

External Searches for ASB15 gene

Genome Databases showing ASB15 gene

Other Databases showing ASB15 gene

Specialized Databases showing ASB15 gene

Intellectual Propertyfor ASB15 gene

Productsfor ASB15 gene

View Random Gene

Aliases
for ASB15 gene

Summaries
for ASB15 gene

Genomic Views
for ASB15 gene

Proteins
for ASB15 gene

Protein Domains /
Families
for ASB15 gene

Function
for ASB15 gene

Pathways & Interactions
for ASB15 gene

Drugs & Compounds
for ASB15 gene

Transcripts
for ASB15 gene

Expression
for ASB15 gene

Orthologs
for ASB15 gene

Paralogs
for ASB15 gene

Genomic Variants
for ASB15 gene

Disorders / Diseases
for ASB15 gene

Publications
for ASB15 gene

Intellectual Property
for ASB15 gene

Products
for ASB15 gene