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Aliases for ASB15 Gene

Aliases for ASB15 Gene

  • Ankyrin Repeat And SOCS Box Containing 15 2 3
  • Ankyrin Repeat And SOCS Box-Containing 15 2
  • ASB-15 4

External Ids for ASB15 Gene

Previous GeneCards Identifiers for ASB15 Gene

  • GC07P121742
  • GC07P122805
  • GC07P122809
  • GC07P122803
  • GC07P122835
  • GC07P123036
  • GC07P123207
  • GC07P117612

Summaries for ASB15 Gene

Entrez Gene Summary for ASB15 Gene

  • This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for ASB15 Gene

ASB15 (Ankyrin Repeat And SOCS Box Containing 15) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is GPR75-ASB3.

UniProtKB/Swiss-Prot for ASB15 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB15 Gene

Genomics for ASB15 Gene

Regulatory Elements for ASB15 Gene

Genomic Location for ASB15 Gene

Start:
123,567,010 bp from pter
End:
123,639,481 bp from pter
Size:
72,472 bases
Orientation:
Plus strand

Genomic View for ASB15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB15 Gene

Proteins for ASB15 Gene

  • Protein details for ASB15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXK1-ASB15_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 15
    Protein Accession:
    Q8WXK1
    Secondary Accessions:
    • Q3ZCP3
    • Q3ZCP5
    • Q68D37

    Protein attributes for ASB15 Gene

    Size:
    588 amino acids
    Molecular mass:
    65799 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASB15 Gene

Proteomics data for ASB15 Gene at MOPED

Post-translational modifications for ASB15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB15 Gene

No data available for DME Specific Peptides for ASB15 Gene

Domains for ASB15 Gene

Gene Families for ASB15 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB15 Gene

Suggested Antigen Peptide Sequences for ASB15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXK1

UniProtKB/Swiss-Prot:

ASB15_HUMAN :
  • Q8WXK1
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 9 ANK repeats.
genes like me logo Genes that share domains with ASB15: view

Function for ASB15 Gene

Molecular function for ASB15 Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASB15: view

Phenotypes for ASB15 Gene

GenomeRNAi human phenotypes for ASB15:
genes like me logo Genes that share phenotypes with ASB15: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASB15 Gene

Localization for ASB15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB15 Gene COMPARTMENTS Subcellular localization image for ASB15 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB15 Gene

Pathways for ASB15 Gene

genes like me logo Genes that share pathways with ASB15: view

UniProtKB/Swiss-Prot Q8WXK1-ASB15_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB15: view

Transcripts for ASB15 Gene

mRNA/cDNA for ASB15 Gene

(8) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(10) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB15 Gene

Ankyrin repeat and SOCS box containing 15:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASB15

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ASB15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - -
SP2: -
SP3:
SP4: - - -
SP5: - - - - -
SP6:

Relevant External Links for ASB15 Gene

GeneLoc Exon Structure for
ASB15
ECgene alternative splicing isoforms for
ASB15

Expression for ASB15 Gene

mRNA expression in normal human tissues for ASB15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB15 Gene

This gene is overexpressed in Muscle - Skeletal (20.1), Heart - Left Ventricle (19.8), and Heart - Atrial Appendage (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB15 Gene

SOURCE GeneReport for Unigene cluster for ASB15 Gene Hs.83916

genes like me logo Genes that share expressions with ASB15: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ASB15 Gene

Orthologs for ASB15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASB15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB15 35
  • 99.38 (n)
  • 99.32 (a)
ASB15 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB15 35
  • 90.01 (n)
  • 91.82 (a)
ASB15 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB15 35
  • 91.91 (n)
  • 93.07 (a)
ASB15 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb15 35
  • 85.71 (n)
  • 88.51 (a)
Asb15 16
Asb15 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASB15 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Asb15 35
  • 85.08 (n)
  • 89.37 (a)
chicken
(Gallus gallus)
Aves ASB15 35
  • 74.91 (n)
  • 76.11 (a)
ASB15 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB15 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb15 35
  • 68.9 (n)
  • 68.61 (a)
zebrafish
(Danio rerio)
Actinopterygii asb15a 36
  • 50 (a)
OneToMany
asb15b 35
  • 57.41 (n)
  • 55.21 (a)
asb15b 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M60.7 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for ASB15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASB15 Gene

ENSEMBL:
Gene Tree for ASB15 (if available)
TreeFam:
Gene Tree for ASB15 (if available)

Paralogs for ASB15 Gene

Paralogs for ASB15 Gene

Selected SIMAP similar genes for ASB15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASB15: view

Variants for ASB15 Gene

Sequence variations from dbSNP and Humsavar for ASB15 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3034907 -- 123,628,195(+) AAGAC(-/TC)TTCTT intron-variant
rs3993666 -- 123,629,922(+) ATATG(-/GC)ATATT intron-variant
rs4140837 -- 123,609,203(+) ATAAA(A/T)ttgta intron-variant
rs4140838 -- 123,609,154(+) ACCTG(A/C)ATCTC intron-variant
rs4621745 -- 123,635,126(+) CTATA(G/T)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB15 Gene

Variant ID Type Subtype PubMed ID
nsv889125 CNV Gain 21882294
nsv831116 CNV Gain+Loss 17160897
nsv508479 CNV Loss 20534489

Relevant External Links for ASB15 Gene

HapMap Linkage Disequilibrium report
ASB15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB15 Gene

Disorders for ASB15 Gene

No disorders were found for ASB15 Gene.

No data available for UniProtKB/Swiss-Prot for ASB15 Gene

Publications for ASB15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification and characterization of ankyrin repeat and SOCS box-containing gene ASB15 in silico. (PMID: 16012773) Yoshida K. (Int. J. Mol. Med. 2005) 3 23
  3. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3

Products for ASB15 Gene

Sources for ASB15 Gene

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