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Aliases for ASB15 Gene

Aliases for ASB15 Gene

  • Ankyrin Repeat And SOCS Box Containing 15 2 3 5
  • Ankyrin Repeat And SOCS Box-Containing 15 2
  • ASB-15 4

External Ids for ASB15 Gene

Previous GeneCards Identifiers for ASB15 Gene

  • GC07P121742
  • GC07P122805
  • GC07P122809
  • GC07P122803
  • GC07P122835
  • GC07P123036
  • GC07P123207
  • GC07P117612

Summaries for ASB15 Gene

Entrez Gene Summary for ASB15 Gene

  • This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for ASB15 Gene

ASB15 (Ankyrin Repeat And SOCS Box Containing 15) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. An important paralog of this gene is ASB3.

UniProtKB/Swiss-Prot for ASB15 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB15 Gene

Genomics for ASB15 Gene

Regulatory Elements for ASB15 Gene

Enhancers for ASB15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ASB15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB15 Gene

Chromosome:
7
Start:
123,566,999 bp from pter
End:
123,639,481 bp from pter
Size:
72,483 bases
Orientation:
Plus strand

Genomic View for ASB15 Gene

Genes around ASB15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB15 Gene

Proteins for ASB15 Gene

  • Protein details for ASB15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXK1-ASB15_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 15
    Protein Accession:
    Q8WXK1
    Secondary Accessions:
    • Q3ZCP3
    • Q3ZCP5
    • Q68D37

    Protein attributes for ASB15 Gene

    Size:
    588 amino acids
    Molecular mass:
    65799 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASB15 Gene

Proteomics data for ASB15 Gene at MOPED

Post-translational modifications for ASB15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASB15 Gene

Domains & Families for ASB15 Gene

Gene Families for ASB15 Gene

Protein Domains for ASB15 Gene

Suggested Antigen Peptide Sequences for ASB15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXK1

UniProtKB/Swiss-Prot:

ASB15_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 9 ANK repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 9 ANK repeats.
genes like me logo Genes that share domains with ASB15: view

Function for ASB15 Gene

Molecular function for ASB15 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with ASB15: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB15 Gene

Localization for ASB15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB15 Gene COMPARTMENTS Subcellular localization image for ASB15 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB15 Gene

Pathways & Interactions for ASB15 Gene

genes like me logo Genes that share pathways with ASB15: view

UniProtKB/Swiss-Prot Q8WXK1-ASB15_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with ASB15: view

No data available for SIGNOR curated interactions for ASB15 Gene

Drugs & Compounds for ASB15 Gene

No Compound Related Data Available

Transcripts for ASB15 Gene

mRNA/cDNA for ASB15 Gene

(10) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB15 Gene

Ankyrin repeat and SOCS box containing 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - -
SP2: -
SP3:
SP4: - - -
SP5: - - - - -
SP6:

Relevant External Links for ASB15 Gene

GeneLoc Exon Structure for
ASB15
ECgene alternative splicing isoforms for
ASB15

Expression for ASB15 Gene

mRNA expression in normal human tissues for ASB15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB15 Gene

This gene is overexpressed in Muscle - Skeletal (x20.1), Heart - Left Ventricle (x19.8), and Heart - Atrial Appendage (x9.3).

Protein differential expression in normal tissues from HIPED for ASB15 Gene

This gene is overexpressed in Breast (45.3), Plasma (12.9), and Heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB15 Gene



SOURCE GeneReport for Unigene cluster for ASB15 Gene Hs.83916

genes like me logo Genes that share expression patterns with ASB15: view

Protein tissue co-expression partners for ASB15 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ASB15 Gene

Orthologs for ASB15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASB15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASB15 35
  • 90.01 (n)
  • 91.82 (a)
ASB15 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB15 35
  • 91.91 (n)
  • 93.07 (a)
ASB15 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb15 35
  • 85.71 (n)
  • 88.51 (a)
Asb15 16
Asb15 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASB15 35
  • 99.38 (n)
  • 99.32 (a)
ASB15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb15 35
  • 85.08 (n)
  • 89.37 (a)
oppossum
(Monodelphis domestica)
Mammalia ASB15 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves ASB15 35
  • 74.91 (n)
  • 76.11 (a)
ASB15 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB15 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb15 35
  • 68.9 (n)
  • 68.61 (a)
zebrafish
(Danio rerio)
Actinopterygii asb15b 35
  • 57.41 (n)
  • 55.21 (a)
asb15a 36
  • 50 (a)
OneToMany
asb15b 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M60.7 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for ASB15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASB15 Gene

ENSEMBL:
Gene Tree for ASB15 (if available)
TreeFam:
Gene Tree for ASB15 (if available)

Paralogs for ASB15 Gene

Paralogs for ASB15 Gene

(3) SIMAP similar genes for ASB15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASB15: view

Variants for ASB15 Gene

Sequence variations from dbSNP and Humsavar for ASB15 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_060466 -
rs4731112 - 123,629,064(+) TTTTG(C/G)CGTTT reference, missense
rs6948517 -- 123,608,486(+) TTTTG(C/G)ACTAA intron-variant, upstream-variant-2KB
rs12669165 -- 123,631,138(+) AGGAT(C/T)TTTTT intron-variant
rs12674003 -- 123,634,240(+) tgttc(C/T)cctcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB15 Gene

Variant ID Type Subtype PubMed ID
nsv889125 CNV Gain 21882294
nsv831116 CNV Gain+Loss 17160897
nsv508479 CNV Loss 20534489

Variation tolerance for ASB15 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ASB15 Gene

Disorders for ASB15 Gene

Relevant External Links for ASB15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB15

No disorders were found for ASB15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB15 Gene

Publications for ASB15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Identification and characterization of ankyrin repeat and SOCS box-containing gene ASB15 in silico. (PMID: 16012773) Yoshida K. (Int. J. Mol. Med. 2005) 3 23
  3. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  4. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3
  5. Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PMID: 17672918) Szafranski K. … Platzer M. (Genome Biol. 2007) 3

Products for ASB15 Gene

Sources for ASB15 Gene

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