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Aliases for ASB15 Gene

Aliases for ASB15 Gene

  • Ankyrin Repeat And SOCS Box Containing 15 2 3 5
  • Ankyrin Repeat And SOCS Box-Containing 15 2
  • ASB-15 4

External Ids for ASB15 Gene

Previous GeneCards Identifiers for ASB15 Gene

  • GC07P121742
  • GC07P122805
  • GC07P122809
  • GC07P122803
  • GC07P122835
  • GC07P123036
  • GC07P123207
  • GC07P117612

Summaries for ASB15 Gene

Entrez Gene Summary for ASB15 Gene

  • This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for ASB15 Gene

ASB15 (Ankyrin Repeat And SOCS Box Containing 15) is a Protein Coding gene. Diseases associated with ASB15 include Retinitis Pigmentosa 11. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB14.

UniProtKB/Swiss-Prot for ASB15 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB15 Gene

Genomics for ASB15 Gene

Regulatory Elements for ASB15 Gene

Enhancers for ASB15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G123643 1.5 Ensembl ENCODE dbSUPER 10.2 +77.1 77089 2.0 PKNOX1 ATF1 FEZF1 ZNF2 YY1 ZNF766 GATA2 FOS DEK YY2 ASB15 RNU6-11P ENSG00000272686 LMOD2 LOC102724555
GH07G123608 1.2 ENCODE dbSUPER 10.8 +42.5 42518 1.1 HDAC1 PKNOX1 ATF1 NFRKB ZNF766 ELK1 CEBPB ZEB2 ZNF592 POLR2H LMOD2 ASB15 IQUB NDUFA5 LOC102724555
GH07G123537 1.2 Ensembl ENCODE 10.6 -27.8 -27800 3.4 PKNOX1 ATF1 ARNT TCF12 GATA2 FOS JUNB NCOA1 SMARCB1 ZNF592 ASB15 NDUFA5 IQUB
GH07G123645 0.9 ENCODE dbSUPER 10.2 +78.6 78582 0.8 CTCF RBBP5 CHD7 RAD21 NR2F2 YY1 JUND ZNF701 POU5F1 HNF4A LOC102724555 WASL ASB15 RNU6-11P LMOD2
GH07G123602 0.8 dbSUPER 11.1 +35.9 35892 0.4 PKNOX1 ESRRA BACH1 ZMYM3 GATA3 CTBP1 ZNF316 FOS NFE2 RCOR1 LOC102724555 LMOD2 ASB15 IQUB NDUFA5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB15 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB15 Gene

Chromosome:
7
Start:
123,566,999 bp from pter
End:
123,639,481 bp from pter
Size:
72,483 bases
Orientation:
Plus strand

Genomic View for ASB15 Gene

Genes around ASB15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB15 Gene

Proteins for ASB15 Gene

  • Protein details for ASB15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXK1-ASB15_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 15
    Protein Accession:
    Q8WXK1
    Secondary Accessions:
    • Q3ZCP3
    • Q3ZCP5
    • Q68D37

    Protein attributes for ASB15 Gene

    Size:
    588 amino acids
    Molecular mass:
    65799 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ASB15 Gene

Post-translational modifications for ASB15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASB15 Gene

Domains & Families for ASB15 Gene

Gene Families for ASB15 Gene

Suggested Antigen Peptide Sequences for ASB15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXK1

UniProtKB/Swiss-Prot:

ASB15_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB15: view

Function for ASB15 Gene

Molecular function for ASB15 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with ASB15: view
genes like me logo Genes that share phenotypes with ASB15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB15 Gene

Localization for ASB15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB15 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ASB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASB15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB15 Gene

Pathways & Interactions for ASB15 Gene

genes like me logo Genes that share pathways with ASB15: view

UniProtKB/Swiss-Prot Q8WXK1-ASB15_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB15: view

No data available for SIGNOR curated interactions for ASB15 Gene

Transcripts for ASB15 Gene

mRNA/cDNA for ASB15 Gene

(5) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(12) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB15 Gene

Ankyrin repeat and SOCS box containing 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - -
SP2: -
SP3:
SP4: - - -
SP5: - - - - -
SP6:

Relevant External Links for ASB15 Gene

GeneLoc Exon Structure for
ASB15
ECgene alternative splicing isoforms for
ASB15

Expression for ASB15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB15 Gene

This gene is overexpressed in Muscle - Skeletal (x20.1), Heart - Left Ventricle (x19.8), and Heart - Atrial Appendage (x9.3).

Protein differential expression in normal tissues from HIPED for ASB15 Gene

This gene is overexpressed in Breast (45.3), Plasma (12.9), and Heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB15 Gene



Protein tissue co-expression partners for ASB15 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB15 Gene:

ASB15

SOURCE GeneReport for Unigene cluster for ASB15 Gene:

Hs.83916

Evidence on tissue expression from TISSUES for ASB15 Gene

  • Liver(4.2)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with ASB15: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB15 Gene

Orthologs for ASB15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASB15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB15 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia ASB15 34 35
  • 91.91 (n)
cow
(Bos Taurus)
Mammalia ASB15 34 35
  • 90.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ASB15 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb15 34 16 35
  • 85.71 (n)
rat
(Rattus norvegicus)
Mammalia Asb15 34
  • 85.08 (n)
chicken
(Gallus gallus)
Aves ASB15 34 35
  • 74.91 (n)
lizard
(Anolis carolinensis)
Reptilia ASB15 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb15 34
  • 68.9 (n)
zebrafish
(Danio rerio)
Actinopterygii asb15b 34 35
  • 57.41 (n)
asb15a 35
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M60.7 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for ASB15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASB15 Gene

ENSEMBL:
Gene Tree for ASB15 (if available)
TreeFam:
Gene Tree for ASB15 (if available)

Paralogs for ASB15 Gene

Paralogs for ASB15 Gene

(3) SIMAP similar genes for ASB15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASB15: view

Variants for ASB15 Gene

Sequence variations from dbSNP and Humsavar for ASB15 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000037413 -- 123,583,351(+) GAAGT(A/G)GGAAC intron-variant
rs1000061682 -- 123,599,846(+) AACTA(G/T)TCCTT intron-variant, upstream-variant-2KB
rs1000093336 -- 123,617,173(+) GATGA(G/T)GTTAA intron-variant, upstream-variant-2KB
rs1000115003 -- 123,599,508(+) TTTTT(-/C)AGGAA intron-variant
rs1000176521 -- 123,625,655(+) GTGAC(A/G)CTGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ASB15 Gene

Variant ID Type Subtype PubMed ID
esv3614858 CNV loss 21293372
esv3891198 CNV gain 25118596
nsv508479 CNV deletion 20534489
nsv831116 CNV gain+loss 17160897

Variation tolerance for ASB15 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB15 Gene

Disorders for ASB15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ASB15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 11
  • rp11
- elite association - COSMIC cancer census association via MalaCards
Search ASB15 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ASB15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB15
genes like me logo Genes that share disorders with ASB15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ASB15 Gene

Publications for ASB15 Gene

  1. Identification and characterization of ankyrin repeat and SOCS box-containing gene ASB15 in silico. (PMID: 16012773) Yoshida K. (Int. J. Mol. Med. 2005) 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
  4. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for ASB15 Gene

Sources for ASB15 Gene

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