Aliases for ASB14 Gene
Aliases for ASB14 Gene
External Ids for ASB14 Gene
- HGNC: 19766
- Entrez Gene: 142686
- Ensembl: ENSG00000239388
- UniProtKB: A6NK59
Previous GeneCards Identifiers for ASB14 Gene
- GC03P056205
- GC03M056656
- GC03M057157
- GC03M057259
Summaries for ASB14 Gene
-
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2008]
GeneCards Summary for ASB14 Gene
ASB14 (Ankyrin Repeat And SOCS Box Containing 14) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB15.
UniProtKB/Swiss-Prot for ASB14 Gene
-
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB14 Gene
Genomics for ASB14 Gene
Regulatory Elements for ASB14 Gene
Enhancers for ASB14 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ASB14 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ASB14 gene promoter:
Regulatory Element Products
Genomic Location for ASB14 Gene
- Chromosome:
- 3
- Start:
- 57,268,347 bp from pter
- End:
- 57,292,720 bp from pter
- Size:
- 24,374 bases
- Orientation:
- Minus strand
Genomic View for ASB14 Gene
Genes around ASB14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p14.3 by Ensembl
- 3p14.3 by Entrez Gene
- 3p14.3 by HGNC
ASB14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASB14 Gene
Proteins for ASB14 Gene
-
Protein details for ASB14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NK59-ASB14_HUMAN
- Recommended name:
- Ankyrin repeat and SOCS box protein 14
- Protein Accession:
- A6NK59
- C9JX97
- Q8WXK2
- Q92816
Protein attributes for ASB14 Gene
- Size:
- 587 amino acids
- Molecular mass:
- 65331 Da
- Quaternary structure:
- No Data Available
Protein Expression for ASB14 Gene
Post-translational modifications for ASB14 Gene
Other Protein References for ASB14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ASB14
- antibodies-online Antibodies for ASB14: See all 5
- Search GeneTex for Antibodies for ASB14
Protein Products
-
OriGene Purified Proteins for ASB14
- Search Origene for MassSpec and Protein Over-expression Lysates for ASB14
- Origene Custom Protein Services for ASB14
- antibodies-online Proteins for ASB14: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ASB14
Assay Products
- antibodies-online Kits for ASB14: See all 9
No data available for DME Specific Peptides for ASB14 Gene
Domains & Families for ASB14 Gene
Gene Families for ASB14 Gene
Protein Domains for ASB14 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASB14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A6NK59UniProtKB/Swiss-Prot:
ASB14_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Belongs to the ankyrin SOCS box (ASB) family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Family:
-
- Belongs to the ankyrin SOCS box (ASB) family.
Function for ASB14 Gene
Molecular function for ASB14 Gene
- UniProtKB/Swiss-Prot Function:
- May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IBA | -- |
| GO:0031625 | ubiquitin protein ligase binding | IBA | -- |
Phenotypes for ASB14 Gene
- GenomeRNAi human phenotypes for ASB14:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASB14
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB14 gene
- Search ViGene Biosciences for ASB14
CRISPR Products
-
OriGene CRISPR knockouts for ASB14
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASB14
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miRNA Products
- Search ViGene Biosciences for ASB14
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for ASB14 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for ASB14
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ASB14
-
ViGene Biosciences adenoviral particle packaged cDNA for ASB14 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB14 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB14 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB14 Gene
Localization for ASB14 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IBA | -- |
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB14 Gene
Pathways & Interactions for ASB14 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for ASB14 Gene
4 Reactome pathways for ASB14 Gene
UniProtKB/Swiss-Prot A6NK59-ASB14_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ASB14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for ASB14 Gene
Transcripts for ASB14 Gene
mRNA/cDNA for ASB14 Gene
- (4) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASB14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ASB14
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASB14
- GenScript: Design CRISPR guide RNA sequences for ASB14
miRNA Products
- Search ViGene Biosciences for ASB14
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASB14
- Browse OriGene Inhibitory RNA Products For ASB14
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB14 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASB14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB14
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ASB14 Gene
mRNA differential expression in normal tissues according to GTEx for ASB14 Gene
This gene is overexpressed in Muscle - Skeletal (x15.2) and Heart - Left Ventricle (x8.8).
This gene is overexpressed in Adipocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB14 Gene
NURSA nuclear receptor signaling pathways regulating expression of ASB14 Gene:
ASB14SOURCE GeneReport for Unigene cluster for ASB14 Gene:
Hs.665154Primer Products
-
OriGene qPCR primer pairs for ASB14
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB14 Gene
Orthologs for ASB14 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASB14 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASB14 34 |
|
||
| DNAH12 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ASB14 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Asb14 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asb14 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ASB14 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ASB14 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ASB14 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ASB14 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | asb14 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC568371 34 |
|
||
| asb14 35 |
|
OneToMany | |||
| FP017304.1 35 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | M60.7 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ASB14 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ASB14 Gene
Variants for ASB14 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000311115 | -- | 57,291,772(+) | GCATA(A/C)TATCT | intron-variant | |
| rs1000464361 | -- | 57,285,006(+) | GCAAT(C/G)TTGGC | intron-variant | |
| rs1000608787 | -- | 57,285,319(+) | CACTC(-/TT)TCCCT | intron-variant | |
| rs1000609895 | -- | 57,272,686(+) | ACTCC(A/G)CCTCC | intron-variant, utr-variant-3-prime | |
| rs1000642084 | -- | 57,279,278(+) | TTTTT(A/C/T)TTTTT | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3561925 | CNV | deletion | 23714750 |
| esv3575575 | CNV | gain | 25503493 |
| nsv3836 | CNV | insertion | 18451855 |
Gene Damage Index Score:
2.50;
43.72% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ASB14 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASB14
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB14 Gene
Disorders for ASB14 Gene
Relevant External Links for ASB14
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ASB14
No disorders were found for ASB14 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB14 Gene
Publications for ASB14 Gene
- The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
- Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3 64
- The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
- The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
- ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3 64
Products for ASB14 Gene
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- Custom Antibody ServicesOriGene Antibodies for ASB14
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- antibodies-online Antibodies for ASB14: See all 5
- antibodies-online Kits for ASB14: See all 9
- antibodies-online Proteins for ASB14: See all 3
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- Horizon Cell Lines for ASB14
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASB14
- VectorBuilder custom plasmid, inducible vectors for ASB14
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB14
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASB14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (141) ENCODE
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
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- (151) CIViC
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- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer