Aliases for ASB14 Gene
External Ids for ASB14 Gene
Previous GeneCards Identifiers for ASB14 Gene
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2008]
GeneCards Summary for ASB14 Gene
ASB14 (Ankyrin Repeat And SOCS Box Containing 14) is a Protein Coding gene. Diseases associated with ASB14 include Bartonellosis. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. An important paralog of this gene is ASB3.
UniProtKB/Swiss-Prot for ASB14 Gene
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.