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Aliases for ASB14 Gene

Aliases for ASB14 Gene

  • Ankyrin Repeat And SOCS Box Containing 14 2 3
  • Ankyrin Repeat And SOCS Box-Containing 14 2
  • ASB-14 4

External Ids for ASB14 Gene

Previous GeneCards Identifiers for ASB14 Gene

  • GC03P056205
  • GC03M056656
  • GC03M057157
  • GC03M057259

Summaries for ASB14 Gene

Entrez Gene Summary for ASB14 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2008]

GeneCards Summary for ASB14 Gene

ASB14 (Ankyrin Repeat And SOCS Box Containing 14) is a Protein Coding gene. Diseases associated with ASB14 include cat-scratch disease and junctional epidermolysis bullosa. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB15.

UniProtKB/Swiss-Prot for ASB14 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB14 Gene

Genomics for ASB14 Gene

Regulatory Elements for ASB14 Gene

Genomic Location for ASB14 Gene

Start:
57,268,347 bp from pter
End:
57,292,725 bp from pter
Size:
24,379 bases
Orientation:
Minus strand

Genomic View for ASB14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB14 Gene

Proteins for ASB14 Gene

  • Protein details for ASB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK59-ASB14_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 14
    Protein Accession:
    A6NK59
    Secondary Accessions:
    • C9JX97
    • Q8WXK2
    • Q92816

    Protein attributes for ASB14 Gene

    Size:
    587 amino acids
    Molecular mass:
    65331 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ASB14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB14 Gene

Proteomics data for ASB14 Gene at MOPED

Post-translational modifications for ASB14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB14 Gene

Domains for ASB14 Gene

Gene Families for ASB14 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB14 Gene

Suggested Antigen Peptide Sequences for ASB14 Gene

Graphical View of Domain Structure for InterPro Entry

A6NK59

UniProtKB/Swiss-Prot:

ASB14_HUMAN :
  • A6NK59
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 11 ANK repeats.
genes like me logo Genes that share domains with ASB14: view

Function for ASB14 Gene

Molecular function for ASB14 Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASB14: view

Phenotypes for ASB14 Gene

GenomeRNAi human phenotypes for ASB14:
genes like me logo Genes that share phenotypes with ASB14: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASB14 Gene

Localization for ASB14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB14 Gene COMPARTMENTS Subcellular localization image for ASB14 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 2
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB14 Gene

Pathways for ASB14 Gene

genes like me logo Genes that share pathways with ASB14: view

UniProtKB/Swiss-Prot A6NK59-ASB14_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB14: view

Transcripts for ASB14 Gene

mRNA/cDNA for ASB14 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB14 Gene

Ankyrin repeat and SOCS box containing 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASB14

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ASB14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB14 Gene

No ASD Table

Relevant External Links for ASB14 Gene

GeneLoc Exon Structure for
ASB14
ECgene alternative splicing isoforms for
ASB14

Expression for ASB14 Gene

mRNA expression in normal human tissues for ASB14 Gene

mRNA differential expression in normal tissues according to GTEx for ASB14 Gene

This gene is overexpressed in Muscle - Skeletal (15.2) and Heart - Left Ventricle (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB14 Gene

SOURCE GeneReport for Unigene cluster for ASB14 Gene Hs.665154

genes like me logo Genes that share expressions with ASB14: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ASB14 Gene

Orthologs for ASB14 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASB14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB14 35
  • 99.77 (n)
  • 99.49 (a)
ASB14 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB14 35
  • 89.16 (n)
  • 88.53 (a)
DNAH12 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB14 35
  • 88.87 (n)
  • 89.95 (a)
ASB14 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb14 35
  • 83.25 (n)
  • 83.3 (a)
Asb14 16
Asb14 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASB14 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB14 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb14 35
  • 82.08 (n)
  • 82.94 (a)
chicken
(Gallus gallus)
Aves ASB14 35
  • 70.78 (n)
  • 68.95 (a)
ASB14 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB14 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb14 35
  • 63.02 (n)
  • 66.67 (a)
zebrafish
(Danio rerio)
Actinopterygii asb14 36
  • 57 (a)
OneToMany
FP017304.1 36
  • 56 (a)
OneToMany
LOC568371 35
  • 57.7 (n)
  • 56.72 (a)
worm
(Caenorhabditis elegans)
Secernentea M60.7 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for ASB14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASB14 Gene

ENSEMBL:
Gene Tree for ASB14 (if available)
TreeFam:
Gene Tree for ASB14 (if available)

Paralogs for ASB14 Gene

Paralogs for ASB14 Gene

Selected SIMAP similar genes for ASB14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASB14: view

Variants for ASB14 Gene

Sequence variations from dbSNP and Humsavar for ASB14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs528035 -- 57,289,142(+) AATAC(A/G)TATGT intron-variant
rs534240 -- 57,292,659(+) CAGCA(C/G)TGAAG utr-variant-5-prime
rs536036 -- 57,292,855(+) CTTCA(A/G)TGCTA upstream-variant-2KB
rs883244 -- 57,287,888(+) AACAA(G/T)GTATT intron-variant
rs907778 -- 57,287,617(-) atgga(A/G)caggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB14 Gene

Variant ID Type Subtype PubMed ID
nsv3836 CNV Insertion 18451855

Relevant External Links for ASB14 Gene

HapMap Linkage Disequilibrium report
ASB14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB14 Gene

Disorders for ASB14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ASB14 Gene including...

Search for ASB14 Gene in MalaCards »

(2) University of Copenhagen DISEASES for ASB14 Gene

genes like me logo Genes that share disorders with ASB14: view

No data available for UniProtKB/Swiss-Prot for ASB14 Gene

Publications for ASB14 Gene

  1. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3
  4. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4

Products for ASB14 Gene

Sources for ASB14 Gene

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