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Aliases for ASB13 Gene

Aliases for ASB13 Gene

  • Ankyrin Repeat And SOCS Box Containing 13 2 3
  • Ankyrin Repeat And SOCS Box-Containing 13 2
  • ASB-13 4

External Ids for ASB13 Gene

Previous GeneCards Identifiers for ASB13 Gene

  • GC10M005625
  • GC10M005831
  • GC10M005684
  • GC10M005720
  • GC10M005611

Summaries for ASB13 Gene

Entrez Gene Summary for ASB13 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for ASB13 Gene

ASB13 (Ankyrin Repeat And SOCS Box Containing 13) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.

UniProtKB/Swiss-Prot for ASB13 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for ASB13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB13 Gene

Genomics for ASB13 Gene

Regulatory Elements for ASB13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ASB13 Gene

5,638,857 bp from pter
5,666,595 bp from pter
27,739 bases
Minus strand

Genomic View for ASB13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB13 Gene

Proteins for ASB13 Gene

  • Protein details for ASB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat and SOCS box protein 13
    Protein Accession:
    Secondary Accessions:
    • A8K7Q6
    • D3DRR2
    • Q96EP7
    • Q9H8Z1

    Protein attributes for ASB13 Gene

    278 amino acids
    Molecular mass:
    30007 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAL57350.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for ASB13 Gene


neXtProt entry for ASB13 Gene

Proteomics data for ASB13 Gene at MOPED

Post-translational modifications for ASB13 Gene

No Post-translational modifications

Other Protein References for ASB13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ASB13 Gene

Domains for ASB13 Gene

Gene Families for ASB13 Gene

  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB13 Gene

Suggested Antigen Peptide Sequences for ASB13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WXK3
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ASB13: view

Function for ASB13 Gene

Molecular function for ASB13 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with ASB13: view

Phenotypes for ASB13 Gene

GenomeRNAi human phenotypes for ASB13:
genes like me logo Genes that share phenotypes with ASB13: view

Animal Model Products

miRNA for ASB13 Gene

miRTarBase miRNAs that target ASB13

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASB13 Gene

Localization for ASB13 Gene

Subcellular locations from

Jensen Localization Image for ASB13 Gene COMPARTMENTS Subcellular localization image for ASB13 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB13 Gene

Pathways for ASB13 Gene

genes like me logo Genes that share pathways with ASB13: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q8WXK3-ASB13_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB13: view

Transcripts for ASB13 Gene

Unigene Clusters for ASB13 Gene

Ankyrin repeat and SOCS box containing 13:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASB13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB13 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: - -

Relevant External Links for ASB13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASB13 Gene

mRNA expression in normal human tissues for ASB13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB13 Gene

SOURCE GeneReport for Unigene cluster for ASB13 Gene Hs.445899

genes like me logo Genes that share expressions with ASB13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for ASB13 Gene

Orthologs for ASB13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ASB13 35
  • 87.89 (n)
  • 92.45 (a)
ASB13 36
  • 92 (a)
(Canis familiaris)
Mammalia ASB13 35
  • 88.93 (n)
  • 96.23 (a)
ASB13 36
  • 90 (a)
(Mus musculus)
Mammalia Asb13 35
  • 87.29 (n)
  • 97.84 (a)
Asb13 16
Asb13 36
  • 98 (a)
(Pan troglodytes)
Mammalia ASB13 35
  • 99.04 (n)
  • 99.64 (a)
ASB13 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Asb13 35
  • 86.93 (n)
  • 96.04 (a)
(Monodelphis domestica)
Mammalia ASB13 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia ASB13 36
  • 75 (a)
(Gallus gallus)
Aves ASB13 35
  • 78.03 (n)
  • 87.64 (a)
ASB13 36
  • 84 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
-- 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia asb13 35
  • 66.67 (n)
  • 76.28 (a)
(Danio rerio)
Actinopterygii asb13b 35
  • 67.41 (n)
  • 71.64 (a)
asb13a.1 36
  • 50 (a)
asb13a.2 36
  • 60 (a)
asb13b 36
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4234 36
  • 31 (a)
Species with no ortholog for ASB13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB13 Gene

Gene Tree for ASB13 (if available)
Gene Tree for ASB13 (if available)

Paralogs for ASB13 Gene

Paralogs for ASB13 Gene

Selected SIMAP similar genes for ASB13 Gene using alignment to 1 proteins: Pseudogenes for ASB13 Gene

genes like me logo Genes that share paralogs with ASB13: view

Variants for ASB13 Gene

Sequence variations from dbSNP and Humsavar for ASB13 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1573 -- 5,638,933(+) GCTCT(A/G)CTGTG utr-variant-3-prime, nc-transcript-variant
rs1575 -- 5,639,003(+) ACCCA(A/G)TGCTT utr-variant-3-prime, nc-transcript-variant
rs871747 -- 5,659,798(+) TGCTC(A/G)TGCAG intron-variant
rs871748 -- 5,659,832(+) CCAGA(C/T)GCATC intron-variant
rs871749 -- 5,659,870(+) CTGCC(A/G)CTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB13 Gene

Variant ID Type Subtype PubMed ID
nsv523491 CNV Gain 19592680
dgv215e1 CNV Complex 17122850
dgv216e1 CNV Complex 17122850
dgv217e1 CNV Complex 17122850
nsv519582 CNV Gain 19592680
nsv894807 CNV Loss 21882294
nsv8599 CNV Gain 18304495
nsv466720 CNV Gain 19166990
nsv470917 CNV Gain 18288195
nsv818742 CNV Gain 17921354
nsv442170 CNV CNV 18776908
dgv19e55 CNV Gain 17911159
dgv218e1 CNV Complex 17122850
esv998388 CNV Insertion 20482838
esv1243199 CNV Insertion 17803354
nsv894808 CNV Loss 21882294
esv2731784 CNV Deletion 23290073
esv2731795 CNV Deletion 23290073
esv2731807 CNV Deletion 23290073
esv2731818 CNV Deletion 23290073
esv2731829 CNV Deletion 23290073
nsv894809 CNV Loss 21882294

Relevant External Links for ASB13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB13 Gene

Disorders for ASB13 Gene

Relevant External Links for ASB13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ASB13 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ASB13 Gene

Publications for ASB13 Gene

  1. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48

Products for ASB13 Gene

Sources for ASB13 Gene

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