Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASB13 Gene

Aliases for ASB13 Gene

  • Ankyrin Repeat And SOCS Box Containing 13 2 3 5
  • Ankyrin Repeat And SOCS Box-Containing 13 2
  • ASB-13 4

External Ids for ASB13 Gene

Previous GeneCards Identifiers for ASB13 Gene

  • GC10M005625
  • GC10M005831
  • GC10M005684
  • GC10M005720
  • GC10M005611

Summaries for ASB13 Gene

Entrez Gene Summary for ASB13 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for ASB13 Gene

ASB13 (Ankyrin Repeat And SOCS Box Containing 13) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB9.

UniProtKB/Swiss-Prot for ASB13 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for ASB13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB13 Gene

Genomics for ASB13 Gene

Regulatory Elements for ASB13 Gene

Enhancers for ASB13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G005642 1.6 Ensembl ENCODE dbSUPER 22.3 +21.5 21546 4.7 HDGF PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ASB13 LOC102723629 ENSG00000226647 CALML5 GDI2 CALML3-AS1 ENSG00000256462 CALML3 LOC105376384 LOC105376382
GH10G005631 1.4 Ensembl ENCODE dbSUPER 23.5 +34.0 34003 2.6 ELF3 PKNOX1 ARID4B SIN3A RAD21 RARA YY1 FOS MIXL1 EGR2 ASB13 FAM208B GDI2 LOC102723629
GH10G005628 1.3 Ensembl ENCODE dbSUPER 24 +37.2 37212 2.4 FOXA2 RB1 ARID4B ZNF2 THRB ZNF48 ZBTB40 RAD21 YY1 ZNF143 ASB13 FAM208B NET1 ENSG00000228685 RN7SL445P
GH10G005622 1.5 Ensembl ENCODE dbSUPER 18.7 +43.4 43371 1.3 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 ZNF48 ZNF121 ZNF207 ZNF143 ASB13 LOC105376384 CALML3 CALML3-AS1 ENSG00000256462 CALML5 ENSG00000226647 LOC102723629 LOC105376382 ENSG00000228685
GH10G005617 1.3 ENCODE dbSUPER 16.9 +47.5 47546 3.0 PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 YY1 TCF12 FOS ASB13 LOC102723629 CALML5 CALML3-AS1 ENSG00000256462 CALML3 NET1 ENSG00000228685 LOC105376383
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASB13 on UCSC Golden Path with GeneCards custom track

Promoters for ASB13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023880 395 1201 ATF1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZBTB7B ZNF121

Genomic Location for ASB13 Gene

Chromosome:
10
Start:
5,638,857 bp from pter
End:
5,666,595 bp from pter
Size:
27,739 bases
Orientation:
Minus strand

Genomic View for ASB13 Gene

Genes around ASB13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB13 Gene

Proteins for ASB13 Gene

  • Protein details for ASB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXK3-ASB13_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 13
    Protein Accession:
    Q8WXK3
    Secondary Accessions:
    • A8K7Q6
    • D3DRR2
    • Q96EP7
    • Q9H8Z1

    Protein attributes for ASB13 Gene

    Size:
    278 amino acids
    Molecular mass:
    30007 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL57350.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for ASB13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB13 Gene

Post-translational modifications for ASB13 Gene

No Post-translational modifications

Other Protein References for ASB13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB13 Gene

Domains & Families for ASB13 Gene

Gene Families for ASB13 Gene

Suggested Antigen Peptide Sequences for ASB13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXK3

UniProtKB/Swiss-Prot:

ASB13_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
genes like me logo Genes that share domains with ASB13: view

Function for ASB13 Gene

Molecular function for ASB13 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with ASB13: view
genes like me logo Genes that share phenotypes with ASB13: view

Animal Model Products

CRISPR Products

miRNA for ASB13 Gene

miRTarBase miRNAs that target ASB13

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB13 Gene

Localization for ASB13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASB13 gene
Compartment Confidence
cytosol 3
extracellular 2
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ASB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASB13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB13 Gene

Pathways & Interactions for ASB13 Gene

genes like me logo Genes that share pathways with ASB13: view

UniProtKB/Swiss-Prot Q8WXK3-ASB13_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ASB13: view

No data available for SIGNOR curated interactions for ASB13 Gene

Drugs & Compounds for ASB13 Gene

No Compound Related Data Available

Transcripts for ASB13 Gene

Unigene Clusters for ASB13 Gene

Ankyrin repeat and SOCS box containing 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB13 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: - -
SP7:

Relevant External Links for ASB13 Gene

GeneLoc Exon Structure for
ASB13
ECgene alternative splicing isoforms for
ASB13

Expression for ASB13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ASB13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB13 Gene



NURSA nuclear receptor signaling pathways regulating expression of ASB13 Gene:

ASB13

SOURCE GeneReport for Unigene cluster for ASB13 Gene:

Hs.445899

Evidence on tissue expression from TISSUES for ASB13 Gene

  • Stomach(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ASB13: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB13 Gene

Orthologs for ASB13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB13 34 35
  • 99.04 (n)
oppossum
(Monodelphis domestica)
Mammalia ASB13 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB13 34 35
  • 88.93 (n)
cow
(Bos Taurus)
Mammalia ASB13 34 35
  • 87.89 (n)
mouse
(Mus musculus)
Mammalia Asb13 34 16 35
  • 87.29 (n)
rat
(Rattus norvegicus)
Mammalia Asb13 34
  • 86.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ASB13 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB13 34 35
  • 78.03 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia asb13 34
  • 66.67 (n)
zebrafish
(Danio rerio)
Actinopterygii asb13b 34 35
  • 67.41 (n)
asb13a.2 35
  • 60 (a)
OneToMany
asb13a.1 35
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4234 35
  • 31 (a)
OneToMany
Species where no ortholog for ASB13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB13 Gene

ENSEMBL:
Gene Tree for ASB13 (if available)
TreeFam:
Gene Tree for ASB13 (if available)

Paralogs for ASB13 Gene

Paralogs for ASB13 Gene

(6) SIMAP similar genes for ASB13 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ASB13 Gene

genes like me logo Genes that share paralogs with ASB13: view

Variants for ASB13 Gene

Sequence variations from dbSNP and Humsavar for ASB13 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000020756 -- 5,659,322(+) GCCCC(C/T)TCCCT intron-variant
rs1000062967 -- 5,643,635(+) TTCAC(A/C)TAAGG intron-variant
rs1000107257 -- 5,638,791(+) AGCCA(C/T)CCCTC downstream-variant-500B
rs1000125349 -- 5,665,399(+) AAAAG(C/T)TGCGG intron-variant
rs1000192664 -- 5,666,544(+) CCCGG(G/T)GCTCC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ASB13 Gene

Variant ID Type Subtype PubMed ID
dgv19e55 CNV gain 17911159
dgv665n100 CNV gain 25217958
esv1243199 CNV insertion 17803354
esv2731784 CNV deletion 23290073
esv2731795 CNV deletion 23290073
esv2731807 CNV deletion 23290073
esv2731818 CNV deletion 23290073
esv2731829 CNV deletion 23290073
esv2759729 CNV gain 17122850
esv2760149 CNV gain 21179565
esv3310522 CNV novel sequence insertion 20981092
esv3390720 CNV insertion 20981092
esv3622232 CNV gain 21293372
esv998388 CNV insertion 20482838
nsv1054888 CNV gain 25217958
nsv442170 CNV gain 18776908
nsv466720 CNV gain 19166990
nsv470917 CNV gain 18288195
nsv519582 CNV gain 19592680
nsv523491 CNV gain 19592680
nsv549892 CNV gain 21841781
nsv549893 CNV loss 21841781
nsv818742 CNV gain 17921354
nsv8599 CNV gain 18304495
nsv975791 CNV duplication 23825009

Variation tolerance for ASB13 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB13 Gene

Disorders for ASB13 Gene

Relevant External Links for ASB13

Genetic Association Database (GAD)
ASB13
Human Genome Epidemiology (HuGE) Navigator
ASB13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB13

No disorders were found for ASB13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB13 Gene

Publications for ASB13 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64

Products for ASB13 Gene

Sources for ASB13 Gene

Content
Loading form....