Aliases for ASB13 Gene
Aliases for ASB13 Gene
External Ids for ASB13 Gene
- HGNC: 19765
- Entrez Gene: 79754
- Ensembl: ENSG00000196372
- OMIM: 615055
- UniProtKB: Q8WXK3
Previous GeneCards Identifiers for ASB13 Gene
- GC10M005625
- GC10M005831
- GC10M005684
- GC10M005720
- GC10M005611
Summaries for ASB13 Gene
-
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for ASB13 Gene
ASB13 (Ankyrin Repeat And SOCS Box Containing 13) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB9.
UniProtKB/Swiss-Prot for ASB13 Gene
-
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB13 Gene
Genomics for ASB13 Gene
Regulatory Elements for ASB13 Gene
- Transcription factor binding sites by QIAGEN in the ASB13 gene promoter:
Regulatory Element Products
Genomic Location for ASB13 Gene
- Chromosome:
- 10
- Start:
- 5,638,857 bp from pter
- End:
- 5,666,595 bp from pter
- Size:
- 27,739 bases
- Orientation:
- Minus strand
Genomic View for ASB13 Gene
- Cytogenetic band:
-
- 10p15.1 by Ensembl
- 10p15.1 by Entrez Gene
- 10p15.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASB13 Gene
Proteins for ASB13 Gene
-
Protein details for ASB13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WXK3-ASB13_HUMAN
- Recommended name:
- Ankyrin repeat and SOCS box protein 13
- Protein Accession:
- Q8WXK3
- A8K7Q6
- D3DRR2
- Q96EP7
- Q9H8Z1
Protein attributes for ASB13 Gene
- Size:
- 278 amino acids
- Molecular mass:
- 30007 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAL57350.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};
Protein Expression for ASB13 Gene
Post-translational modifications for ASB13 Gene
Other Protein References for ASB13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ASB13
-
Abcam antibodies for ASB13
- Invitrogen Antibodies for ASB13
- antibodies-online Antibodies for ASB13: See all 20
- Search GeneTex for Antibodies for ASB13
Protein Products
-
OriGene Purified Proteins for ASB13
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- ProSpec Recombinant Proteins for ASB13
- antibodies-online Proteins for ASB13: See all 10
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-
ProSci Proteins for ASB13
-
Abcam proteins for ASB13
Assay Products
- antibodies-online Kits for ASB13: See all 9
No data available for DME Specific Peptides for ASB13 Gene
Domains & Families for ASB13 Gene
Gene Families for ASB13 Gene
Protein Domains for ASB13 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASB13 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WXK3UniProtKB/Swiss-Prot:
ASB13_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Belongs to the ankyrin SOCS box (ASB) family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Family:
-
- Belongs to the ankyrin SOCS box (ASB) family.
Function for ASB13 Gene
Molecular function for ASB13 Gene
- UniProtKB/Swiss-Prot Function:
- May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16169070 |
Phenotypes for ASB13 Gene
- GenomeRNAi human phenotypes for ASB13:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB13 gene
-
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CRISPR Products
-
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-
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miRNA for ASB13 Gene
- miRTarBase miRNAs that target ASB13
miRNA Products
- Search ViGene Biosciences for ASB13
Inhibitory RNA Products
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-
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Clone Products
-
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- VectorBuilder custom plasmid, inducible vectors for ASB13
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ASB13
-
ViGene Biosciences adenoviral particle packaged cDNA for ASB13 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB13 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB13 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB13 Gene
Localization for ASB13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB13 Gene
Pathways & Interactions for ASB13 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for ASB13 Gene
4 Reactome pathways for ASB13 Gene
UniProtKB/Swiss-Prot Q8WXK3-ASB13_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ASB13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for ASB13 Gene
Transcripts for ASB13 Gene
mRNA/cDNA for ASB13 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASB13 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ASB13
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASB13
- GenScript: Design CRISPR guide RNA sequences for ASB13
miRNA Products
- Search ViGene Biosciences for ASB13
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASB13
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-
ViGene Biosciences ready-to-package AAV shRNAs for ASB13 gene
Clone Products
-
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASB13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB13
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||
| SP7: |
Expression for ASB13 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB13 Gene
NURSA nuclear receptor signaling pathways regulating expression of ASB13 Gene:
ASB13SOURCE GeneReport for Unigene cluster for ASB13 Gene:
Hs.445899Evidence on tissue expression from TISSUES for ASB13 Gene
- Stomach(4.2)
- Nervous system(2.5)
Primer Products
-
OriGene qPCR primer pairs for ASB13
-
OriGene qPCR primer pairs and template standards for ASB13
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB13 Gene
Orthologs for ASB13 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASB13 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ASB13 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ASB13 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASB13 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Asb13 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asb13 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ASB13 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ASB13 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | asb13 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | asb13b 34 35 |
|
||
| asb13a.2 35 |
|
OneToMany | |||
| asb13a.1 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4234 35 |
|
OneToMany |
- Species where no ortholog for ASB13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ASB13 Gene
(6) SIMAP similar genes for ASB13 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for ASB13 Gene
Variants for ASB13 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000020756 | -- | 5,659,322(+) | GCCCC(C/T)TCCCT | intron-variant | |
| rs1000062967 | -- | 5,643,635(+) | TTCAC(A/C)TAAGG | intron-variant | |
| rs1000107257 | -- | 5,638,791(+) | AGCCA(C/T)CCCTC | downstream-variant-500B | |
| rs1000125349 | -- | 5,665,399(+) | AAAAG(C/T)TGCGG | intron-variant | |
| rs1000192664 | -- | 5,666,544(+) | CCCGG(G/T)GCTCC | nc-transcript-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv19e55 | CNV | gain | 17911159 |
| dgv665n100 | CNV | gain | 25217958 |
| esv1243199 | CNV | insertion | 17803354 |
| esv2731784 | CNV | deletion | 23290073 |
| esv2731795 | CNV | deletion | 23290073 |
| esv2731807 | CNV | deletion | 23290073 |
| esv2731818 | CNV | deletion | 23290073 |
| esv2731829 | CNV | deletion | 23290073 |
| esv2759729 | CNV | gain | 17122850 |
| esv2760149 | CNV | gain | 21179565 |
| esv3310522 | CNV | novel sequence insertion | 20981092 |
| esv3390720 | CNV | insertion | 20981092 |
| esv3622232 | CNV | gain | 21293372 |
| esv998388 | CNV | insertion | 20482838 |
| nsv1054888 | CNV | gain | 25217958 |
| nsv442170 | CNV | gain | 18776908 |
| nsv466720 | CNV | gain | 19166990 |
| nsv470917 | CNV | gain | 18288195 |
| nsv519582 | CNV | gain | 19592680 |
| nsv523491 | CNV | gain | 19592680 |
| nsv549892 | CNV | gain | 21841781 |
| nsv549893 | CNV | loss | 21841781 |
| nsv818742 | CNV | gain | 17921354 |
| nsv8599 | CNV | gain | 18304495 |
| nsv975791 | CNV | duplication | 23825009 |
Relevant External Links for ASB13 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASB13
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB13 Gene
Disorders for ASB13 Gene
Relevant External Links for ASB13
No disorders were found for ASB13 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB13 Gene
Publications for ASB13 Gene
- An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
Products for ASB13 Gene
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- Novus Biologicals Antibodies for ASB13
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- Custom Antibody Services
- ProSci Proteins for ASB13
- Horizon Cell Lines for ASB13
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASB13
- VectorBuilder custom plasmid, inducible vectors for ASB13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB13
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASB13 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




