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ASB13 Gene

protein-coding   GIFtS: 53
GCID: GC10M005680

Ankyrin Repeat And SOCS Box Containing 13

(Previous name: ankyrin repeat and SOCS box-containing 13)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And SOCS Box Containing 131 2
Ankyrin Repeat And SOCS Box-Containing 131 2
Ankyrin Repeat And SOCS Box Protein 132
Ankyrin Repeat Domain-Containing SOCS Box Protein Asb-132
ASB-133

External Ids:    HGNC: 197651   Entrez Gene: 797542   Ensembl: ENSG000001963727   OMIM: 6150555   UniProtKB: Q8WXK33   

Export aliases for ASB13 gene to outside databases

Previous GC identifers: GC10M005625 GC10M005831 GC10M005684 GC10M005720 GC10M005611


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASB13 Gene:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of
proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of
cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly
targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not
protein-coding, have been described for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for ASB13 Gene:
ASB13 (ankyrin repeat and SOCS box containing 13) is a protein-coding gene. Diseases associated with ASB13 include narcolepsy. An important paralog of this gene is ASB12.

UniProtKB/Swiss-Prot: ASB13_HUMAN, Q8WXK3
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity)

Gene Wiki entry for ASB13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASB13 gene promoter:
         NF-1   NF-1/L   STAT5A   NF-AT   C/EBPalpha   NF-AT4   NF-AT2   IRF-7A   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASB13 promoter sequence
   Search Chromatin IP Primers for ASB13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

ASB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB13 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M005680:  view genomic region     (about GC identifiers)

Start:
5,680,820 bp from pter      End:
5,708,558 bp from pter
Size:
27,739 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ASB13

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASB13_HUMAN, Q8WXK3 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 13  
Size: 278 amino acids; 30007 Da
Sequence caution: Sequence=AAL57350.1; Type=Frameshift; Positions=14;
Secondary accessions: A8K7Q6 D3DRR2 Q96EP7 Q9H8Z1
Alternative splicing: 2 isoforms:  Q8WXK3-1   Q8WXK3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASB13: NX_Q8WXK3

Explore proteomics data for ASB13 at MOPED


See ASB13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_078977.2  
ENSEMBL proteins: 
 ENSP00000350331   ENSP00000433358  
Reactome Protein details: Q8WXK3

ASB13 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for ASB13

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ASB13 Assay Products:

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Cloud-Clone Corp. ELISAs for ASB13
Cloud-Clone Corp. CLIAs for ASB13


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing

3 InterPro protein domains:
 IPR002110 Ankyrin_rpt
 IPR001496 SOCS_C
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q8WXK3

ProtoNet protein and cluster: Q8WXK3

2 Blocks protein domains:
IPB001496 SOCS protein
IPB002110 Ankyrin repeat signature


UniProtKB/Swiss-Prot: ASB13_HUMAN, Q8WXK3
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
E3 ubiquitin-protein ligase complexes (By similarity)
Similarity: Contains 6 ANK repeats
Similarity: Contains 1 SOCS box domain


ASB13 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ASB13_HUMAN, Q8WXK3
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI16169070
     
ASB13 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for ASB13:
 Decreased viability with pacli  Increased S DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASB13
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASB13

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASB13
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASB13

miRNA
Products:
    
miRTarBase miRNAs that target ASB13:
hsa-mir-181b-5p (MIRT047299), hsa-mir-148b-3p (MIRT019461)

Block miRNA regulation of human, mouse, rat ASB13 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ASB13 (see all 11):
hsa-miR-579 hsa-miR-4324 hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-449c* hsa-miR-2110 hsa-miR-125b hsa-miR-491-5p
SwitchGear 3'UTR luciferase reporter plasmidASB13 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for ASB13
Predesigned siRNA for gene silencing in human, mouse, rat ASB13

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for ASB13

Clone
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OriGene clones in human, mouse for ASB13 (see all 6)
OriGene ORF clones in mouse, rat for ASB13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ASB13 (NM_024701)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB13
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB13

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for ASB13 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB13


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
extracellular2
nucleus1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ASB13 About    
See pathways by source

SuperPathContained pathways About
1Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ASB13
    Antigen processing: Ubiquitination & Proteasome degradation


UniProtKB/Swiss-Prot: ASB13_HUMAN, Q8WXK3
Pathway: Protein modification; protein ubiquitination


ASB13 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including ASB13: 

          Lymphoma in human mouse rat
          Ubiquitin Ligases in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for ASB13

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for ASB13 (Q8WXK31, 2, 3 ENSP000003503314) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
MARK3P274481, 2, 3, ENSP000004113974EBI-707573,EBI-707595 MINT-63623 I2D: score=4 STRING: ENSP00000411397
HIF1ANQ9NWT62, 3, ENSP000002991634MINT-67057 I2D: score=5 STRING: ENSP00000299163
NUDT3O959892, 3MINT-8264651 MINT-63332 I2D: score=5 
DNM1Q051932, 3MINT-64668 I2D: score=4 
TRIP13Q156452, 3, ENSP000001663454MINT-66460 I2D: score=5 STRING: ENSP00000166345
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IEA--
GO:0035556intracellular signal transduction IEA--

ASB13 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ASB13



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ASB13 gene: 
NM_024701.3  

Unigene Cluster for ASB13:

Ankyrin repeat and SOCS box containing 13
Hs.445899  [show with all ESTs]
Unigene Representative Sequence: BC012056
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000493897 ENST00000357700(uc001iig.2 uc009xic.2) ENST00000459912(uc001iih.2)
ENST00000479033(uc001iii.2) ENST00000482921
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat ASB13 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ASB13 (see all 11):
hsa-miR-579 hsa-miR-4324 hsa-miR-125a-5p hsa-miR-520d-5p hsa-miR-449c* hsa-miR-2110 hsa-miR-125b hsa-miR-491-5p
SwitchGear 3'UTR luciferase reporter plasmidASB13 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ASB13
Predesigned siRNA for gene silencing in human, mouse, rat ASB13
Clone
Products:
     
OriGene clones in human, mouse for ASB13 (see all 6)
OriGene ORF clones in mouse, rat for ASB13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ASB13 (NM_024701)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB13
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB13
Primer
Products:
    
OriGene qPCR primer pairs and template standards for ASB13
OriGene qSTAR qPCR primer pairs in human, mouse for ASB13
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB13
  QuantiTect SYBR Green Assays in human, mouse, rat ASB13
  QuantiFast Probe-based Assays in human, mouse, rat ASB13

Additional mRNA sequence: 

AF403031.1 AK023196.1 AK091935.1 AK292071.1 BC012056.1 CR457302.1 NR_024581.1 NR_037164.1 

9 DOTS entries:

DT.454542  DT.99946977  DT.99957796  DT.100792696  DT.100699987  DT.121265359  DT.40216036  DT.423416 
DT.91762231 

Selected AceView cDNA sequences (see all 137):

CR612381 BM806082 CD677601 BM551539 CR621326 AF403031 BQ013301 CA396754 
BM547359 BQ898229 CB139386 AL557468 BG436652 AU131694 CD300744 BF739898 
AW574658 AI377400 BI084918 CA431580 AI473785 CB217062 AW149040 AL530186 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ASB13 (see all 7)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1:                    -                 -                                             
SP2:                    -                 -     -                                       
SP3:                    -                 -     -                                       
SP4:                    -     -           -     -                                       
SP5:                                            -                                       


ECgene alternative splicing isoforms for ASB13

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ASB13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAATAACAAC
ASB13 Expression
About this image


ASB13 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Blood (Hematopoietic System)
         Monocytes Peripheral Blood
ASB13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ASB13 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.445899
    Pathway & Disease-focused RT2 Profiler PCR Arrays including ASB13: 
          Lymphoma in human mouse rat
          Ubiquitin Ligases in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for ASB13
OriGene qSTAR qPCR primer pairs in human, mouse for ASB13
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB13
QuantiTect SYBR Green Assays in human, mouse, rat ASB13
QuantiFast Probe-based Assays in human, mouse, rat ASB13
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB13

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ASB13 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Asb131 , 5 ankyrin repeat and SOCS box-containing 131, 5 87.29(n)1
97.84(a)1
  13 (2.03 cM)5
1426881  NM_178283.41  NP_840068.11 
 36340325 
chicken
(Gallus gallus)
Aves ASB131 ankyrin repeat and SOCS box containing 13 78.03(n)
87.64(a)
  416691  NM_001199294.1  NP_001186223.1 
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
69(a)
66(a)
many → 1
many → 1
AAWZ02040812(1122-5775)
GL344071.1(94246-104159)
tropical clawed frog
(Xenopus tropicalis)
Amphibia asb131 ankyrin repeat and SOCS box containing 13 66.67(n)
76.28(a)
  100135113  XM_002931850.2  XP_002931896.1 
zebrafish
(Danio rerio)
Actinopterygii asb13b1 ankyrin repeat and SOCS box containing 13b 67.41(n)
71.64(a)
  556808  XM_679710.5  XP_684802.4 


ENSEMBL Gene Tree for ASB13 (if available)
TreeFam Gene Tree for ASB13 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ASB13 gene
ASB122  ASB12  ASB112  ASB52  ASB92  
6 SIMAP similar genes for ASB13 using alignment to 1 protein entry:     ASB13_HUMAN:
DKFZp313J0816    ASB5    ASB11    DKFZp779E2460    ASB9    ANKRD28

ASB13 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for ASB13
PGOHUM00000240931


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ASB13 (see all 799)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs580270651,2
--5680322(+) AGATCA/GTGCCA 3 -- ds50010--------
rs78970161,2
C--5680323(+) gatcgC/Tgccac 3 -- ds50017Minor allele frequency- T:0.08NA WA CSA 13
rs1873879421,2
--5680397(+) CCTGAC/TGCTGG 3 -- ds50010--------
rs1478890921,2
--5680510(+) TTTCCA/GGAACA 3 -- ds50010--------
rs1438225621,2
C--5680630(+) CCAAGA/GAAAGT 3 -- ds50010--------
rs47499221,2
C,F,A,H--5680689(+) ATGGGA/GAAGTG 3 -- ds500112Minor allele frequency- G:0.16NS EA NA WA 752
rs1142403781,2
C,F--5680715(+) CACAGC/TGCTGC 3 -- ds50011Minor allele frequency- T:0.02WA 118
rs1910543371,2
--5680725(+) CCAAAC/TGACCT 3 -- ds50010--------
rs46016551,2
C,F,A,H--5680738(+) GACACA/GGCAAG 3 -- ds500120Minor allele frequency- G:0.29NS EA NA WA CSA 2346
rs23866491,2
C,F,O,A,H--5680842(-) GTGGCG/AGAATA 3 -- ut31 nc-transcript-variant32Minor allele frequency- A:0.36EA NA NS WA CSA 4736

HapMap Linkage Disequilibrium report for ASB13 (5680820 - 5708558 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ASB13 (see all 22):    About this table    
Variant IDTypeSubtypePubMed ID
esv2731818CNV Deletion23290073
esv2731807CNV Deletion23290073
esv2731784CNV Deletion23290073
esv2731829CNV Deletion23290073
esv2731795CNV Deletion23290073
esv1243199CNV Insertion17803354
esv998388CNV Insertion20482838
nsv894808CNV Loss21882294
nsv894809CNV Loss21882294
nsv894807CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ASB13
DNA2.0 Custom Variant and Variant Library Synthesis for ASB13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 615055    OMIM disorders: --

1 disease for ASB13:    
About MalaCards
narcolepsy


ASB13 for disorders           About GeneDecksing

Genetic Association Database (GAD): ASB13
Human Genome Epidemiology (HuGE) Navigator: ASB13 (1 document)

Export disorders for ASB13 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ASB13 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with ASB13)
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  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
  5. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
  6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
  7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
  8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
  9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  10. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1 Kohroki J.... Masuho Y. (FEBS Lett. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79754 HGNC: 19765 AceView: ASB13 Ensembl:ENSG00000196372 euGenes: HUgn79754
ECgene: ASB13 H-InvDB: ASB13

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ASB13 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ASB13 gene:
Search GeneIP for patents involving ASB13

GeneCards and IP:
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