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Aliases for ASB12 Gene

Aliases for ASB12 Gene

  • Ankyrin Repeat And SOCS Box Containing 12 2 3
  • Ankyrin Repeat And SOCS Box-Containing 12 2
  • ASB-12 4

External Ids for ASB12 Gene

Previous GeneCards Identifiers for ASB12 Gene

  • GC0XM059664
  • GC0XM060909
  • GC0XM061677
  • GC0XM062310
  • GC0XM063227
  • GC0XM063360
  • GC0XM063444
  • GC0XM057267

Summaries for ASB12 Gene

Entrez Gene Summary for ASB12 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASB12 Gene

ASB12 (Ankyrin Repeat And SOCS Box Containing 12) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.

UniProtKB/Swiss-Prot for ASB12 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB12 Gene

Genomics for ASB12 Gene

Regulatory Elements for ASB12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ASB12 Gene

Start:
64,224,192 bp from pter
End:
64,230,631 bp from pter
Size:
6,440 bases
Orientation:
Minus strand

Genomic View for ASB12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB12 Gene

Proteins for ASB12 Gene

  • Protein details for ASB12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXK4-ASB12_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 12
    Protein Accession:
    Q8WXK4
    Secondary Accessions:
    • J3KP57
    • Q2M3D5
    • Q52LK4
    • Q6ISF9
    • Q8N8F5

    Protein attributes for ASB12 Gene

    Size:
    309 amino acids
    Molecular mass:
    33943 Da
    Quaternary structure:
    • Interacts with CUL5 and RNF7.

    Alternative splice isoforms for ASB12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB12 Gene

Proteomics data for ASB12 Gene at MOPED

Post-translational modifications for ASB12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB12 Gene

Domains for ASB12 Gene

Gene Families for ASB12 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB12 Gene

Suggested Antigen Peptide Sequences for ASB12 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXK4

UniProtKB/Swiss-Prot:

ASB12_HUMAN :
  • Q8WXK4
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with ASB12: view

Function for ASB12 Gene

Molecular function for ASB12 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASB12: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASB12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASB12 Gene

Localization for ASB12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB12 Gene COMPARTMENTS Subcellular localization image for ASB12 gene
Compartment Confidence
cytoskeleton 2
cytosol 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB12 Gene

Pathways for ASB12 Gene

genes like me logo Genes that share pathways with ASB12: view

UniProtKB/Swiss-Prot Q8WXK4-ASB12_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB12: view

Transcripts for ASB12 Gene

mRNA/cDNA for ASB12 Gene

(16) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB12 Gene

Ankyrin repeat and SOCS box containing 12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASB12

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB12 Gene

No ASD Table

Relevant External Links for ASB12 Gene

GeneLoc Exon Structure for
ASB12
ECgene alternative splicing isoforms for
ASB12

Expression for ASB12 Gene

mRNA expression in normal human tissues for ASB12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ASB12 Gene

This gene is overexpressed in Muscle - Skeletal (49.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASB12 Gene

SOURCE GeneReport for Unigene cluster for ASB12 Gene Hs.56281

genes like me logo Genes that share expressions with ASB12: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for ASB12 Gene

Orthologs for ASB12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASB12 35
  • 90.27 (n)
  • 91.8 (a)
ASB12 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB12 35
  • 90.88 (n)
  • 92.45 (a)
ASB12 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb12 35
  • 85.17 (n)
  • 88.64 (a)
Asb12 16
Asb12 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASB12 35
  • 99.16 (n)
  • 98.74 (a)
ASB12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb12 35
  • 83.66 (n)
  • 88.96 (a)
oppossum
(Monodelphis domestica)
Mammalia ASB12 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB12 35
  • 65.17 (n)
  • 66.99 (a)
ASB12 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB12 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb12.2 35
  • 57.87 (n)
  • 58.31 (a)
MGC75891 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24697 35
zebrafish
(Danio rerio)
Actinopterygii asb12b 35
  • 58.93 (n)
  • 59.8 (a)
asb12a 36
  • 56 (a)
OneToMany
asb12b 36
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1268 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for ASB12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB12 Gene

ENSEMBL:
Gene Tree for ASB12 (if available)
TreeFam:
Gene Tree for ASB12 (if available)

Paralogs for ASB12 Gene

Paralogs for ASB12 Gene

Selected SIMAP similar genes for ASB12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ASB12: view

Variants for ASB12 Gene

Sequence variations from dbSNP and Humsavar for ASB12 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1414368 -- 64,225,579(+) TTGTC(A/G)GGCTG reference, synonymous-codon
rs1414369 -- 64,229,564(+) ctagc(A/G)aagtc intron-variant
rs1414370 -- 64,229,875(+) TAGTA(A/C)ATTTT intron-variant
rs1537764 -- 64,226,562(+) CACTG(C/G)CTCCC intron-variant
rs5964744 -- 64,229,266(+) GGGAA(A/G)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB12 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv521560 CNV Gain 19592680

Relevant External Links for ASB12 Gene

HapMap Linkage Disequilibrium report
ASB12
Locus Specific Mutation Databases (LSDB)
ASB12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB12 Gene

Disorders for ASB12 Gene

(2) University of Copenhagen DISEASES for ASB12 Gene

genes like me logo Genes that share disorders with ASB12: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ASB12 Gene

Publications for ASB12 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3 4
  5. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3

Products for ASB12 Gene

Sources for ASB12 Gene

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