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ASB12 Gene

protein-coding   GIFtS: 50
GCID: GC0XM063444

Ankyrin Repeat And SOCS Box Containing 12

(Previous name: ankyrin repeat and SOCS box-containing 12)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And SOCS Box Containing 121 2
Ankyrin Repeat And SOCS Box-Containing 121 2
Ankyrin Repeat And SOCS Box Protein 122
Ankyrin Repeat Domain-Containing SOCS Box Protein Asb-122
ASB-123

External Ids:    HGNC: 197631   Entrez Gene: 1426892   Ensembl: ENSG000001988817   OMIM: 3008915   UniProtKB: Q8WXK43   

Export aliases for ASB12 gene to outside databases

Previous GC identifers: GC0XM059664 GC0XM060909 GC0XM061677 GC0XM062310 GC0XM063227 GC0XM063360 GC0XM057267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASB12 Gene:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of
proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of
cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly
targeting them for degradation. (provided by RefSeq, Jan 2011)

GeneCards Summary for ASB12 Gene:
ASB12 (ankyrin repeat and SOCS box containing 12) is a protein-coding gene. An important paralog of this gene is ASB13.

UniProtKB/Swiss-Prot: ASB12_HUMAN, Q8WXK4
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASB12 gene promoter:
         Bach1   LHX3b/Lhx3b   FOXF2   HSF1 (long)   CUTL1   STAT5A   Ik-3   PPAR-alpha   LHX3a/Lhx3a   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASB12 promoter sequence
   Search Chromatin IP Primers for ASB12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq11.2   Ensembl cytogenetic band:  Xq11.2   HGNC cytogenetic band: Xq11.1

ASB12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB12 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM063444:  view genomic region     (about GC identifiers)

Start:
63,444,072 bp from pter      End:
63,450,511 bp from pter
Size:
6,440 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASB12_HUMAN, Q8WXK4 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 12  
Size: 309 amino acids; 33943 Da
Subunit: Interacts with CUL5 and RNF7
Secondary accessions: J3KP57 Q2M3D5 Q52LK4 Q6ISF9 Q8N8F5
Alternative splicing: 2 isoforms:  Q8WXK4-1   Q8WXK4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASB12: NX_Q8WXK4

Explore proteomics data for ASB12 at MOPED


See ASB12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_569059.3  
ENSEMBL proteins: 
 ENSP00000355195   ENSP00000379435  
Reactome Protein details: Q8WXK4

ASB12 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing

3 InterPro protein domains:
 IPR002110 Ankyrin_rpt
 IPR001496 SOCS_C
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q8WXK4

ProtoNet protein and cluster: Q8WXK4

2 Blocks protein domains:
IPB001496 SOCS protein
IPB002110 Ankyrin repeat signature


UniProtKB/Swiss-Prot: ASB12_HUMAN, Q8WXK4
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
E3 ubiquitin-protein ligase complexes (By similarity)
Similarity: Contains 5 ANK repeats
Similarity: Contains 1 SOCS box domain


Find genes that share domains with ASB12           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ASB12_HUMAN, Q8WXK4
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with ASB12           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASB12
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miRNA
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5 qRT-PCR Assays for microRNAs that regulate ASB12:
hsa-miR-3679-5p hsa-miR-766 hsa-miR-1185 hsa-miR-646 hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidASB12 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ASB12

Gene Editing
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GenScript: all cDNA clones in your preferred vector: ASB12 (NM_130388)
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Cell Line
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton2
cytosol1
extracellular1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ASB12 About    
See pathways by source

SuperPathContained pathways About
1Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84


Find genes that share SuperPaths with ASB12           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ASB12
    Antigen processing: Ubiquitination & Proteasome degradation


UniProtKB/Swiss-Prot: ASB12_HUMAN, Q8WXK4
Pathway: Protein modification; protein ubiquitination

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASB12
Interactions:

    Search GeneGlobe Interaction Network for ASB12

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

Selected Interacting proteins for ASB12 (Q8WXK42, 3 ENSP000003551954) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

InteractantInteraction Details
GeneCardExternal ID(s)
RNF7Q9UBF62, 3, ENSP000002734804MINT-77975 I2D: score=2 STRING: ENSP00000273480
CUL5Q930342, 3MINT-77976 I2D: score=2 
LZTR1Q8N6533, ENSP000002157394I2D: score=1 STRING: ENSP00000215739
HOXA2O433643I2D: score=1 
MYOCDQ8IZQ83I2D: score=1 
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IEA--
GO:0035556intracellular signal transduction IEA--

Find genes that share ontologies with ASB12           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ASB12



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ASB12 gene: 
NM_130388.3  

Unigene Cluster for ASB12:

Ankyrin repeat and SOCS box containing 12
Hs.56281  [show with all ESTs]
Unigene Representative Sequence: NM_130388
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000362002(uc004dvq.2 uc004dvr.2) ENST00000396130
miRNA
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Block miRNA regulation of human, mouse, rat ASB12 using miScript Target Protectors
5 qRT-PCR Assays for microRNAs that regulate ASB12:
hsa-miR-3679-5p hsa-miR-766 hsa-miR-1185 hsa-miR-646 hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidASB12 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ASB12
Predesigned siRNA for gene silencing in human, mouse, rat ASB12
Clone
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OriGene ORF clones in mouse, rat for ASB12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ASB12 (NM_130388)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB12
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB12
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB12
  QuantiTect SYBR Green Assays in human, mouse, rat ASB12
  QuantiFast Probe-based Assays in human, mouse, rat ASB12

Additional mRNA sequence: 

AF403030.1 AK096896.1 AK300684.1 BC069436.1 BC069555.1 BC093883.1 BC104946.1 

1 DOTS entry:

DT.410807 

16 AceView cDNA sequences:

AK096896 BC069555 BX107270 NM_130388 BC069436 AA633985 AA349954 F34438 
AF403030 W76256 AA778891 W72063 W58499 F25532 F18362 W58534 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ASB12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ASB12 Expression
About this image


ASB12 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Heart (Cardiovascular System)
         Atrioventricular Canal Cells Atrioventricular Canal
ASB12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ASB12 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.56281
    Custom PCR Arrays for ASB12
Primer
Products:
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB12
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB12

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ASB12 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Asb121 , 5 ankyrin repeat and SOCS box-containing 121, 5 85.17(n)1
88.64(a)1
  X (41.99 cM)5
703921  NM_080858.31  NP_543134.11 
 954702015 
chicken
(Gallus gallus)
Aves ASB121 ankyrin repeat and SOCS box containing 12 65.17(n)
66.99(a)
  422313  NM_001277670.1  NP_001264599.1 
lizard
(Anolis carolinensis)
Reptilia ASB126
ankyrin repeat and SOCS box containing 12
64(a)
1 ↔ 1
GL343875.1(55620-57797)
African clawed frog
(Xenopus laevis)
Amphibia Xl.246972 Xenopus laevis transcribed sequence with weak similarity more 75.47(n)    CB198136.2 
zebrafish
(Danio rerio)
Actinopterygii asb12b1 ankyrin repeat and SOCS box-containing protein 12b 58.93(n)
59.8(a)
  445507  NM_001004009.2  NP_001004009.1 


ENSEMBL Gene Tree for ASB12 (if available)
TreeFam Gene Tree for ASB12 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ASB12 gene
ASB132  ASB12  ASB112  ASB52  ASB92  
2 SIMAP similar genes for ASB12 using alignment to 1 protein entry:     ASB12_HUMAN:
MTMR8    ASB1

Find genes that share paralogs with ASB12           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ASB12 (see all 147)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1505271361,2
--63450592(+) TCACCA/TATGTA 1 -- ds50010--------
rs1125153101,2
C--63450993(+) CCCCAC/TCCCAC 1 -- us2k10--------
rs1995302321,2
C--63451199(+) CGGAGA/GCATCA 1 -- ut310--------
rs1399283651,2
C,F--63451259(+) ATCAAC/TATGGG 2 I M mis11Minor allele frequency- T:0.00NA 4550
rs96979431,2
C,F--63451272(+) ctattA/Gtgaac 1 -- us2k12Minor allele frequency- G:0.33WA CSA 3
rs2017628661,2
--63451276(+) ATCCAG/TCTGGT 2 M L mis10--------
rs2006519201,2
C--63451278(+) CCAGCC/TGGTTG 2 Q R mis10--------
rs1494249321,2
C,F--63451285(+) GTTGAT/CGGCTT 2 /I /V mis11Minor allele frequency- C:0.00NA 4550
rs2006547941,2
C--63451323(+) TGCGGA/GCGACT 2 A V mis10--------
rs1485895251,2
C,F--63451354(+) TGACCG/ATGGAG 2 /R /W mis11Minor allele frequency- A:0.00NA 4532

HapMap Linkage Disequilibrium report for ASB12 (63444072 - 63450511 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for ASB12:    About this table    
Variant IDTypeSubtypePubMed ID
nsv521560CNV Gain19592680
esv1584074OTHER Inversion17803354

Locus Specific Mutation Databases (LSDB): ASB12

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ASB12
DNA2.0 Custom Variant and Variant Library Synthesis for ASB12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300891    OMIM disorders: --

2 diseases from the University of Copenhagen DISEASES database for ASB12:
Pyloric stenosis     Cleft palate

Find genes that share disorders with ASB12           About GenesLikeMe


Export disorders for ASB12 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ASB12 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with ASB12)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  2. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1, 2 Kohroki J.... Masuho Y. (FEBS Lett. 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
  6. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
  7. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D.... White O. (Nature 1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 142689 HGNC: 19763 AceView: ASB12 Ensembl:ENSG00000198881 euGenes: HUgn142689
ECgene: ASB12 H-InvDB: ASB12

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ASB12 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ASB12 gene:
Search GeneIP for patents involving ASB12

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
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 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ASB12  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for ASB12  
 OriGene qSTAR qPCR primer pairs in human, mouse for ASB12   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for ASB12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for ASB12   OriGene Custom Protein Services for ASB12  

 
 
 Block miRNA regulation of human, mouse, rat ASB12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ASB12
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB12 Predesigned siRNA for gene silencing in human, mouse, rat ASB12
 QuantiFast Probe-based Assays in human, mouse, rat ASB12 QuantiTect SYBR Green Assays in human, mouse, rat ASB12
 Custom PCR Arrays for ASB12 Search Chromatin IP Primers for ASB12
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASB12  Search GeneGlobe Interaction Network for ASB12
 Regulatory tfbs in ASB12 promoter
 GenScript Custom Purified and Recombinant Proteins Services for ASB12 GenScript cDNA clones with any tag delivered in your preferred vector for ASB12
 GenScript Custom Assay Services for ASB12 GenScript Custom overexpressing Cell Line Services for ASB12
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
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 Search Tocris compounds for ASB12
 Browse Sino Biological Proteins
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 Protein Production Services
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 ASB12 antibodies
 Antibodies for ASB12
 See all of Abcam's Antibodies, Kits and Proteins for ASB12
 Custom Antibody / Protein Production Service
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 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for ASB12
 Antibodies for ASB12
 ELISAs for ASB12
 CLIAs for ASB12



 Browse ESI BIO Cell Lines and PureStem Progenitors for ASB12
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB12
 SwitchGear 3'UTR luciferase reporter plasmids for ASB12
 SwitchGear Promoter luciferase reporter plasmids for ASB12
 ThermoFisher Antibodies for ASB12
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB12
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASB12
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASB12
 LSBio Antibodies in human, mouse, rat for ASB12
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for ASB12
  Search eBioscience for proteins for ASB12
  Search eBioscience for elisas for ASB12
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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