Aliases for ASB12 Gene
Aliases for ASB12 Gene
External Ids for ASB12 Gene
- HGNC: 19763
- Entrez Gene: 142689
- Ensembl: ENSG00000198881
- OMIM: 300891
- UniProtKB: Q8WXK4
Previous GeneCards Identifiers for ASB12 Gene
- GC0XM059664
- GC0XM060909
- GC0XM061677
- GC0XM062310
- GC0XM063227
- GC0XM063360
- GC0XM063444
- GC0XM057267
Summaries for ASB12 Gene
-
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jan 2011]
GeneCards Summary for ASB12 Gene
ASB12 (Ankyrin Repeat And SOCS Box Containing 12) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB1.
UniProtKB/Swiss-Prot for ASB12 Gene
-
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB12 Gene
Genomics for ASB12 Gene
Regulatory Elements for ASB12 Gene
- Transcription factor binding sites by QIAGEN in the ASB12 gene promoter:
Regulatory Element Products
Genomic Location for ASB12 Gene
- Chromosome:
- X
- Start:
- 64,224,192 bp from pter
- End:
- 64,230,631 bp from pter
- Size:
- 6,440 bases
- Orientation:
- Minus strand
Genomic View for ASB12 Gene
Genes around ASB12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq11.2 by Ensembl
- Xq11.2 by Entrez Gene
- Xq11.2 by HGNC
ASB12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASB12 Gene
Proteins for ASB12 Gene
-
Protein details for ASB12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WXK4-ASB12_HUMAN
- Recommended name:
- Ankyrin repeat and SOCS box protein 12
- Protein Accession:
- Q8WXK4
- J3KP57
- Q2M3D5
- Q52LK4
- Q6ISF9
- Q8N8F5
Protein attributes for ASB12 Gene
- Size:
- 309 amino acids
- Molecular mass:
- 33943 Da
- Quaternary structure:
-
- Interacts with CUL5 and RNF7.
Protein Expression for ASB12 Gene
Post-translational modifications for ASB12 Gene
Other Protein References for ASB12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ASB12
- Novus Biologicals Antibodies for ASB12
-
Abcam antibodies for ASB12
- Invitrogen Antibodies for ASB12
- antibodies-online Antibodies for ASB12: See all 8
- GeneTex ASB12 antibody for ASB12
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ASB12
- Origene Custom Protein Services for ASB12
- Search GeneTex for Proteins for ASB12
Assay Products
- antibodies-online Kits for ASB12: See all 9
No data available for DME Specific Peptides for ASB12 Gene
Domains & Families for ASB12 Gene
Gene Families for ASB12 Gene
Protein Domains for ASB12 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASB12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WXK4UniProtKB/Swiss-Prot:
ASB12_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Belongs to the ankyrin SOCS box (ASB) family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Family:
-
- Belongs to the ankyrin SOCS box (ASB) family.
Function for ASB12 Gene
Molecular function for ASB12 Gene
- UniProtKB/Swiss-Prot Function:
- Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Phenotypes for ASB12 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASB12
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB12 gene
- Search ViGene Biosciences for ASB12
miRNA Products
- Search ViGene Biosciences for ASB12
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASB12
- Browse OriGene Inhibitory RNA Products For ASB12
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB12 gene
Clone Products
-
OriGene ORF clones in human for ASB12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASB12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ASB12
-
ViGene Biosciences adenoviral particle packaged cDNA for ASB12 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB12 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ASB12 Gene
Localization for ASB12 Gene
| Compartment | Confidence |
|---|---|
| cytoskeleton | 2 |
| extracellular | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB12 Gene
Pathways & Interactions for ASB12 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for ASB12 Gene
4 Reactome pathways for ASB12 Gene
UniProtKB/Swiss-Prot Q8WXK4-ASB12_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ASB12 Gene
Selected Interacting proteins:
Q8WXK4-ASB12_HUMAN
ENSP00000355195
for ASB12 Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for ASB12 Gene
Transcripts for ASB12 Gene
mRNA/cDNA for ASB12 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (16) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASB12 Gene
miRNA Products
- Search ViGene Biosciences for ASB12
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ASB12
- Browse OriGene Inhibitory RNA Products For ASB12
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB12 gene
Clone Products
-
OriGene ORF clones in human for ASB12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ASB12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB12
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ASB12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
mRNA differential expression in normal tissues according to GTEx for ASB12 Gene
This gene is overexpressed in Muscle - Skeletal (x49.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB12 Gene
NURSA nuclear receptor signaling pathways regulating expression of ASB12 Gene:
ASB12SOURCE GeneReport for Unigene cluster for ASB12 Gene:
Hs.56281Evidence on tissue expression from TISSUES for ASB12 Gene
- Muscle(4.5)
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for ASB12
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB12 Gene
Orthologs for ASB12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASB12 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ASB12 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASB12 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Asb12 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asb12 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ASB12 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ASB12 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ASB12 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | asb12.2 34 |
|
||
| MGC75891 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24697 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | asb12b 34 35 |
|
||
| asb12a 35 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1268 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ASB12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ASB12 Gene
Variants for ASB12 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000341377 | -- | 64,230,631(+) | GTCAG(A/T)CCCTA | utr-variant-5-prime | |
| rs1000691889 | -- | 64,230,305(+) | TCCTC(C/T)TGGTG | intron-variant | |
| rs1001027259 | -- | 64,228,446(+) | TGCTT(C/T)TACCC | intron-variant | |
| rs1001396249 | -- | 64,228,097(+) | TTTAA(A/G)TACCT | intron-variant | |
| rs1001499945 | -- | 64,225,828(+) | GGCCC(C/T)AAAGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1584074 | OTHER | inversion | 17803354 |
| nsv521560 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.26;
40.53% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ASB12 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASB12
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB12 Gene
Disorders for ASB12 Gene
Relevant External Links for ASB12
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ASB12
No disorders were found for ASB12 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB12 Gene
Publications for ASB12 Gene
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
- ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
Products for ASB12 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ASB12
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ASB12
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- OriGene qPCR primer pairs for ASB12
- OriGene CRISPR knockouts for ASB12
- OriGene ORF clones in human for ASB12
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- GenScript: Next-day shipping cDNA ORF clone for ASB12 in any vector
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- GenScript Custom overexpressing Cell Line Services for ASB12
- Browse GenScript CRISPR for ASB12
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- Browse Sino Biological cDNA Clones
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- Novus Biologicals Antibodies for ASB12
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for ASB12: See all 8
- antibodies-online Kits for ASB12: See all 9
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex ASB12 antibody for ASB12
- Search GeneTex for Proteins for ASB12
- ViGene Biosciences adenoviral particle packaged cDNA for ASB12 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ASB12 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ASB12 gene
- Search ViGene Biosciences for ASB12
- Horizon Cell Lines for ASB12
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASB12
- VectorBuilder custom plasmid, inducible vectors for ASB12
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB12
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASB12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer