Aliases for ASB11 Gene
Aliases for ASB11 Gene
External Ids for ASB11 Gene
- HGNC: 17186
- Entrez Gene: 140456
- Ensembl: ENSG00000165192
- OMIM: 300626
- UniProtKB: Q8WXH4
Previous GeneCards Identifiers for ASB11 Gene
- GC0XM014746
- GC0XM014127
- GC0XM014503
- GC0XM014663
- GC0XM014661
- GC0XM015061
- GC0XM015211
- GC0XM013060
Summaries for ASB11 Gene
-
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for ASB11 Gene
ASB11 (Ankyrin Repeat And SOCS Box Containing 11) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.
UniProtKB/Swiss-Prot for ASB11 Gene
-
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB11 Gene
Genomics for ASB11 Gene
Regulatory Elements for ASB11 Gene
Enhancers for ASB11 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG015333 | 1.4 | FANTOM5 ENCODE | 14.6 | -19.7 | -19656 | 2.9 | HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 ZNF2 YY1 GLIS2 | PIGA ASB11 ZRSR2 CA5B PIR MOSPD2 GC0XM015327 |
| GH0XG015356 | 0.6 | ENCODE | 12.4 | -41.0 | -40977 | 0.1 | HLF CEBPB RAD21 YY1 FOXA1 JUND FOXP2 HNF4A | PIGA ASB11 BMX PIR ACE2 GS1-594A7.3 VEGFD |
| GH0XG015298 | 0.7 | Ensembl ENCODE | 9.3 | +16.7 | 16724 | 1.3 | SCRT1 SCRT2 GABPA | ASB9 PIGA ASB11 |
| GH0XG015300 | 0.6 | ENCODE | 9 | +15.3 | 15334 | 0.2 | HNRNPUL1 CTCF ZNF654 TAF1 ATF2 RAD21 YY1 HNF1A SMC3 | PIGA ASB11 ASB9 |
| GH0XG015309 | 0.6 | ENCODE | 8.7 | +4.9 | 4866 | 2.3 | MEF2D GATA3 PRDM6 NFIB RNF2 ZBTB20 | ASB11 ASB9 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ASB11 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ASB11 gene promoter:
Regulatory Element Products
Genomic Location for ASB11 Gene
- Chromosome:
- X
- Start:
- 15,275,644 bp from pter
- End:
- 15,315,667 bp from pter
- Size:
- 40,024 bases
- Orientation:
- Minus strand
Genomic View for ASB11 Gene
Genes around ASB11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp22.2 by Ensembl
- Xp22.2 by Entrez Gene
- Xp22.2 by HGNC
ASB11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ASB11 Gene
Proteins for ASB11 Gene
-
Protein details for ASB11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WXH4-ASB11_HUMAN
- Recommended name:
- Ankyrin repeat and SOCS box protein 11
- Protein Accession:
- Q8WXH4
- E9PEN1
- Q3SYC4
- Q7Z667
Protein attributes for ASB11 Gene
- Size:
- 323 amino acids
- Molecular mass:
- 35367 Da
- Quaternary structure:
- No Data Available
Protein Expression for ASB11 Gene
Post-translational modifications for ASB11 Gene
Other Protein References for ASB11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ASB11
- Novus Biologicals Antibodies for ASB11
- Invitrogen Antibodies for ASB11
- antibodies-online Antibodies for ASB11: See all 20
- GeneTex ASB11 antibody for ASB11
Protein Products
-
OriGene Purified Proteins for ASB11
- Search Origene for MassSpec and Protein Over-expression Lysates for ASB11
- Origene Custom Protein Services for ASB11
- antibodies-online Proteins for ASB11: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ASB11
Assay Products
- antibodies-online Kits for ASB11: See all 22
No data available for DME Specific Peptides for ASB11 Gene
Domains & Families for ASB11 Gene
Gene Families for ASB11 Gene
Protein Domains for ASB11 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ASB11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WXH4UniProtKB/Swiss-Prot:
ASB11_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Belongs to the ankyrin SOCS box (ASB) family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
- Family:
-
- Belongs to the ankyrin SOCS box (ASB) family.
Function for ASB11 Gene
Molecular function for ASB11 Gene
- UniProtKB/Swiss-Prot Function:
- May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Phenotypes for ASB11 Gene
- GenomeRNAi human phenotypes for ASB11:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB11 gene
-
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- Search ViGene Biosciences for ASB11
CRISPR Products
-
OriGene CRISPR knockouts for ASB11
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASB11
- GenScript: Design CRISPR guide RNA sequences for ASB11
miRNA for ASB11 Gene
- miRTarBase miRNAs that target ASB11
-
- hsa-mir-335-5p (MIRT017058)
- hsa-mir-1277-5p (MIRT503384)
- hsa-mir-297 (MIRT503385)
- hsa-mir-3924 (MIRT503386)
- hsa-mir-190a-3p (MIRT503387)
- hsa-mir-98-3p (MIRT503388)
- hsa-let-7f-1-3p (MIRT503389)
- hsa-let-7b-3p (MIRT503390)
- hsa-let-7a-3p (MIRT503391)
- hsa-mir-567 (MIRT503392)
- hsa-mir-5011-5p (MIRT503393)
- hsa-mir-4666a-3p (MIRT503394)
- hsa-mir-381-3p (MIRT503395)
- hsa-mir-300 (MIRT503396)
- hsa-mir-574-5p (MIRT508361)
- hsa-mir-6867-5p (MIRT508362)
- hsa-mir-223-5p (MIRT508363)
- hsa-mir-4666b (MIRT514701)
- hsa-mir-1909-5p (MIRT514702)
- hsa-mir-3613-3p (MIRT541610)
- hsa-mir-548c-3p (MIRT541611)
- hsa-mir-302c-5p (MIRT716004)
- hsa-mir-210-3p (MIRT716005)
- hsa-mir-3143 (MIRT716006)
- hsa-mir-6820-3p (MIRT716007)
- hsa-mir-3164 (MIRT716008)
- hsa-mir-7157-3p (MIRT716009)
- hsa-mir-6737-3p (MIRT716010)
- hsa-mir-5008-3p (MIRT716011)
- hsa-mir-6889-3p (MIRT716012)
- hsa-mir-4803 (MIRT716013)
miRNA Products
- Search ViGene Biosciences for ASB11
Inhibitory RNA Products
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-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ASB11
-
ViGene Biosciences adenoviral particle packaged cDNA for ASB11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ASB11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB11 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB11 Gene
Localization for ASB11 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| plasma membrane | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB11 Gene
Pathways & Interactions for ASB11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
Pathways by source for ASB11 Gene
4 Reactome pathways for ASB11 Gene
UniProtKB/Swiss-Prot Q8WXH4-ASB11_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for ASB11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
| GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for ASB11 Gene
Transcripts for ASB11 Gene
mRNA/cDNA for ASB11 Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ASB11 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ASB11
-
Santa Cruz Biotechnology (SCBT) CRISPR for ASB11
- GenScript: Design CRISPR guide RNA sequences for ASB11
miRNA Products
- Search ViGene Biosciences for ASB11
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ASB11
- Browse OriGene Inhibitory RNA Products For ASB11
-
ViGene Biosciences ready-to-package AAV shRNAs for ASB11 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ASB11
- VectorBuilder custom plasmid, inducible vectors for ASB11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||
| SP3: | - |
Expression for ASB11 Gene
mRNA differential expression in normal tissues according to GTEx for ASB11 Gene
This gene is overexpressed in Heart - Left Ventricle (x20.3), Muscle - Skeletal (x19.7), and Heart - Atrial Appendage (x9.6).
This gene is overexpressed in Tonsil (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB11 Gene
NURSA nuclear receptor signaling pathways regulating expression of ASB11 Gene:
ASB11SOURCE GeneReport for Unigene cluster for ASB11 Gene:
Hs.352183Evidence on tissue expression from TISSUES for ASB11 Gene
- Liver(4.2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ASB11
-
OriGene qPCR primer pairs for ASB11
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ASB11 Gene
Orthologs for ASB11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ASB11 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ASB11 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ASB11 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Asb11 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Asb11 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ASB11 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ASB11 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ASB11 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ASB11 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | asb11 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | asb11 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4234 35 |
|
OneToMany |
- Species where no ortholog for ASB11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ASB11 Gene
(59) SIMAP similar genes for ASB11 Gene using alignment to 2 proteins:
- DKFZp779E2460
- LYRM4
- AURA2
- CTSS
- ZNF547
- DCTN5
- SHANK2
- TMEM44
- RNF217
- ZNF738
- ZNF737
- UTY
- NF2
- FAM175A
- WARS
- FAM210A
- NSRP1
- FKBP3
- DNMT1
- ASB5
- LEPROTL1
- HKR1
- DKFZp313J0816
- ZNF816
- ZNF585B
- USP10
- LINC00596
- TMSB15B
- ZNF28
- ZNF83
- ZNF763
- ZNF283
- SNX31
- EIF3L
- C4orf21
- ZNF564
- SPAG11B
- SPAG11A
- ASB9
- SEPT2
- MED15
- ZNF212
- SPATS2L
- CHID1
- TMEM14B
- DAPL1
- TSEN2
- ZNF461
- QRICH2
- CRCP
- ZNF20
- TCF4
- BECN1
- ASB13
- ZNF468
- APOD
- PLA2G6
- GLT8D2
- TNFRSF17
Variants for ASB11 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000060589 | -- | 15,282,199(+) | GGGAA(A/C/G)AAAAA | utr-variant-3-prime | |
| rs1000129205 | -- | 15,289,171(+) | CTTGG(C/T)CCCCA | intron-variant | |
| rs1000244218 | -- | 15,289,589(+) | TCATG(A/G)TCAAT | reference, synonymous-codon | |
| rs1000599872 | -- | 15,286,871(+) | AATTT(A/T)GCCCA | intron-variant | |
| rs1000718222 | -- | 15,305,715(+) | AAAAA(A/T)TTTTC | intron-variant |
Residual Variation Intolerance Score:
81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.91;
48.83% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ASB11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ASB11
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB11 Gene
Disorders for ASB11 Gene
Relevant External Links for ASB11
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ASB11
No disorders were found for ASB11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB11 Gene
Publications for ASB11 Gene
- Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 2 3 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 4 64
- Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
- The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
Products for ASB11 Gene
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- Novus Biologicals
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- antibodies-online Antibodies for ASB11: See all 20
- antibodies-online Kits for ASB11: See all 22
- antibodies-online Proteins for ASB11: See all 7
- Search antibodies-online for peptides
- GeneTex ASB11 antibody for ASB11
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- ViGene Biosciences adenoviral particle packaged cDNA for ASB11 gene
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- Search ViGene Biosciences for ASB11
- Horizon Cell Lines for ASB11
- Cyagen custom Knockout/knockin (KOKI) mouse models for ASB11
- VectorBuilder custom plasmid, inducible vectors for ASB11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ASB11
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ASB11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
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