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Aliases for ASB11 Gene

Aliases for ASB11 Gene

  • Ankyrin Repeat And SOCS Box Containing 11 2 3 5
  • Ankyrin Repeat And SOCS Box Containing 11, E3 Ubiquitin Protein Ligase 2 3
  • ASB-11 3 4
  • Ankyrin Repeat Domain-Containing SOCS Box Protein ASB11 3
  • Ankyrin Repeat And SOCS Box-Containing 11 2

External Ids for ASB11 Gene

Previous GeneCards Identifiers for ASB11 Gene

  • GC0XM014746
  • GC0XM014127
  • GC0XM014503
  • GC0XM014663
  • GC0XM014661
  • GC0XM015061
  • GC0XM015211
  • GC0XM013060

Summaries for ASB11 Gene

Entrez Gene Summary for ASB11 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASB11 Gene

ASB11 (Ankyrin Repeat And SOCS Box Containing 11) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is ASB7.

UniProtKB/Swiss-Prot for ASB11 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB11 Gene

Genomics for ASB11 Gene

Regulatory Elements for ASB11 Gene

Genomic Location for ASB11 Gene

Chromosome:
X
Start:
15,275,644 bp from pter
End:
15,315,667 bp from pter
Size:
40,024 bases
Orientation:
Minus strand

Genomic View for ASB11 Gene

Genes around ASB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB11 Gene

Proteins for ASB11 Gene

  • Protein details for ASB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXH4-ASB11_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 11
    Protein Accession:
    Q8WXH4
    Secondary Accessions:
    • E9PEN1
    • Q3SYC4
    • Q7Z667

    Protein attributes for ASB11 Gene

    Size:
    323 amino acids
    Molecular mass:
    35367 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ASB11 Gene

    Alternative splice isoforms for ASB11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB11 Gene

Proteomics data for ASB11 Gene at MOPED

Post-translational modifications for ASB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB11 Gene

Antibody Products

No data available for DME Specific Peptides for ASB11 Gene

Domains & Families for ASB11 Gene

Gene Families for ASB11 Gene

Protein Domains for ASB11 Gene

Suggested Antigen Peptide Sequences for ASB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXH4

UniProtKB/Swiss-Prot:

ASB11_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 6 ANK repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ASB11: view

Function for ASB11 Gene

Molecular function for ASB11 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with ASB11: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB11 Gene

Localization for ASB11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB11 Gene COMPARTMENTS Subcellular localization image for ASB11 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB11 Gene

Pathways & Interactions for ASB11 Gene

genes like me logo Genes that share pathways with ASB11: view

UniProtKB/Swiss-Prot Q8WXH4-ASB11_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB11 Gene

None

No data available for SIGNOR curated interactions for ASB11 Gene

Drugs & Compounds for ASB11 Gene

No Compound Related Data Available

Transcripts for ASB11 Gene

mRNA/cDNA for ASB11 Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB11 Gene

Ankyrin repeat and SOCS box containing 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: -

Relevant External Links for ASB11 Gene

GeneLoc Exon Structure for
ASB11
ECgene alternative splicing isoforms for
ASB11

Expression for ASB11 Gene

mRNA expression in normal human tissues for ASB11 Gene

mRNA differential expression in normal tissues according to GTEx for ASB11 Gene

This gene is overexpressed in Heart - Left Ventricle (x20.3), Muscle - Skeletal (x19.7), and Heart - Atrial Appendage (x9.6).

Protein differential expression in normal tissues from HIPED for ASB11 Gene

This gene is overexpressed in Tonsil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB11 Gene



SOURCE GeneReport for Unigene cluster for ASB11 Gene Hs.352183

genes like me logo Genes that share expression patterns with ASB11: view

Protein tissue co-expression partners for ASB11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ASB11 Gene

Orthologs for ASB11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB11 36
  • 92 (a)
OneToOne
ASB11 35
  • 88.34 (n)
  • 92.26 (a)
dog
(Canis familiaris)
Mammalia ASB11 35
  • 90.2 (n)
  • 94.74 (a)
ASB11 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb11 16
Asb11 35
  • 84.54 (n)
  • 90.11 (a)
Asb11 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASB11 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB11 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb11 35
  • 86.31 (n)
  • 92.78 (a)
chicken
(Gallus gallus)
Aves ASB11 35
  • 72.46 (n)
  • 74.53 (a)
ASB11 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB11 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb11 35
  • 65.94 (n)
  • 66.77 (a)
zebrafish
(Danio rerio)
Actinopterygii asb11 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4234 36
  • 30 (a)
OneToMany
Species with no ortholog for ASB11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB11 Gene

ENSEMBL:
Gene Tree for ASB11 (if available)
TreeFam:
Gene Tree for ASB11 (if available)

Paralogs for ASB11 Gene

Paralogs for ASB11 Gene

genes like me logo Genes that share paralogs with ASB11: view

Variants for ASB11 Gene

Sequence variations from dbSNP and Humsavar for ASB11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs34025595 - 15,287,983(+) ATAGT(C/T)GGTTA reference, missense
rs35859007 - 15,287,941(+) CGCAC(C/T)TTTGC reference, missense
VAR_069428 -
rs5008833 -- 15,294,611(+) AATGA(C/T)CCTCC intron-variant
rs4370686 -- 15,306,032(+) TGGTT(C/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB11 Gene

Variant ID Type Subtype PubMed ID
nsv528343 CNV Gain 19592680
nsv522729 CNV Gain 19592680
nsv517938 CNV Gain 19592680

Variation tolerance for ASB11 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB11 Gene

HapMap Linkage Disequilibrium report
ASB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB11 Gene

Disorders for ASB11 Gene

Relevant External Links for ASB11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB11

No disorders were found for ASB11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB11 Gene

Publications for ASB11 Gene

  1. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 2 3 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  3. The novel gene asb11: a regulator of the size of the neural progenitor compartment. (PMID: 16893969) Diks S.H. … Zivkovic D. (J. Cell Biol. 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 3

Products for ASB11 Gene

Sources for ASB11 Gene

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