ASB11 Gene
protein-coding GIFtS: 48
GCID: GC0XM015298
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ankyrin repeat and SOCS box containing 11(Previous name: ankyrin repeat and SOCS box-containing 11 )
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Aliases for ASB11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ankyrin Repeat And SOCS Box Containing 111 2 | | ASB-112 3 | | DKFZp779E24601 | | Ankyrin Repeat And SOCS Box-Containing 111 | | Ankyrin Repeat And SOCS Box Protein 112 | | Ankyrin Repeat Domain-Containing SOCS Box Protein ASB112 |
Export aliases for ASB11 gene to outside databasesPrevious GC identifers: GC0XM014746 GC0XM014127 GC0XM014503 GC0XM014663 GC0XM014661 GC0XM015061 GC0XM015211 GC0XM013060 |
Summaries for ASB11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ASB11: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins.They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokinesignalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them fordegradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Jan 2011) UniProtKB/Swiss-Prot: ASB11_HUMAN, Q8WXH4Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity)
|
Genomic Views for ASB11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ASB11 gene promoter: HOXA9 CRE-BP1 ATF-2 Meis-1a C/EBPalpha Other transcription factors
Search SABiosciences Chromatin IP Primers for ASB11
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASB11 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.31 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.31ASB11 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM015298: view genomic region
(about GC identifiers)
Start:
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15,298,053 bp from pter |
End:
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15,333,778 bp from pter |
Size:
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35,726 bases |
Orientation:
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minus strand |
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Proteins for ASB11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ASB11_HUMAN, Q8WXH4 (See
protein sequence)Recommended Name: Ankyrin repeat and SOCS box protein 11 Size: 323 amino acids; 35367 Da
Secondary accessions: Q3SYC4 Q7Z667Alternative splicing: 2 isoforms: Q8WXH4-1 Q8WXH4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ASB11: NX_Q8WXH4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXH4 ASB11 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (3 alternative transcripts):
NP_001012428.1 NP_001188512.1 NP_543149.1 ENSEMBL proteins: ENSP00000369837 ENSP00000343408 ENSP00000417914 ENSP00000419385 ENSP00000445465 Reactome Protein details: Q8WXH4 Human Recombinant Protein Products for ASB11:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
ASB11 for ontologies About GeneDecksing
ASB11 Antibody Products: Assay Products for ASB11: |
Protein
Domains / Families for ASB11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASB11 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXH4ProtoNet protein and cluster: Q8WXH4 2 Blocks protein families: IPB001496 SOCS protein IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: ASB11_HUMAN, Q8WXH4Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3ubiquitin-protein ligase complexes (By similarity)Similarity: Contains 6 ANK repeatsSimilarity: Contains 1 SOCS box domain |
Function for ASB11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: ASB11_HUMAN, Q8WXH4Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity)Phenotypes: 1 GenomeRNAi human phenotype for ASB11: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB11 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB11 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ASB11 (NM_001201583) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASB11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB11  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB11 |
|
Pathways & Interactions for ASB11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources See GeneCards unified pathways Show all pathways
5
Reactome Pathways for ASB11
UniProtKB/Swiss-Prot: ASB11_HUMAN, Q8WXH4Pathway: Protein modification; protein ubiquitination
ASB11 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASB11
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- | | GO:0035556 | intracellular signal transduction |
IEA | -- |
ASB11 for ontologies About GeneDecksing
|
Drugs & Compounds for ASB11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ASB11 Search CenterWatch for drugs/clinical trials and news about ASB11 
|
Transcripts for ASB11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ASB11 gene (3 alternative transcripts): NM_001012428.2 NM_001201583.1 NM_080873.2 Unigene Cluster for ASB11: Ankyrin repeat and SOCS box containing 11 Hs.352183 [show with all ESTs]Unigene Representative Sequence: BX5378535 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380470(uc004cwo.2 uc010net.2 uc004cwp.2 uc010nes.2) ENST00000344384 ENST00000480796 ENST00000485437 ENST00000537676
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB11 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB11 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ASB11 (NM_001201583) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASB11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB11  |
Additional cDNA sequence: AF425642.1 BC069340.1 BC103873.1 BC103874.1 BC103875.1 BX537853.1 BX537857.1 3 DOTS entries: DT.97781558 DT.101976646 DT.101977097 7 AceView cDNA sequences: BC069340 AF425642 AL706521 NM_080873 CF551997 BX537857 BX537853 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ASB11 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | |
| SP1: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ASB11
|
Expression for ASB11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASB11 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGGAAGCTAA
 About this image See ASB11 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ASB11
SOURCE GeneReport for Unigene cluster: Hs.352183 SABiosciences Custom PCR Arrays for ASB11
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB11 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ASB11 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASB11 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASB11 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB11 |
Orthologs for ASB11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ASB11 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
ASB116 |
Uncharacterized protein |
75(a) |
1 ↔ 1 |
1(125527662-125539456) |
lizard (Anolis carolinensis) |
Reptilia |
ASB116 |
-- |
76(a) |
1 ↔ 1 |
1(206175441-206178712) |
zebrafish (Danio rerio) |
Actinopterygii |
asb116 |
ankyrin repeat and SOCS box-containing 11 |
45(a) |
1 ↔ 1 |
9(31397975-31405316) |
ENSEMBL Gene Tree for ASB11 (if available) TreeFam Gene Tree for ASB11 (if available)  |
Paralogs for ASB11 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ASB11 gene
- ASB132 ASB122 ASB12 ASB52 ASB92 ASB72
5 SIMAP similar genes for ASB11 using alignment to 3 protein entries: ASB11_HUMAN (see all proteins):DKFZp779E2460 ASB5 DKFZp313J0816 ASB9 ASB13
ASB11 for paralogs About GeneDecksing
|
Genomic Variants for ASB11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr X pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ASB11 (15298053 - 15333778 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ASB11: -- Locus Specific Mutation Databases (LSDB): ASB11
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASB11 |
|
Disorders
/ Diseases for ASB11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASB11 for disorders About MalaCards
ASB11 for disorders About GeneDecksing
OMIM gene information: 300626
OMIM disorders: --
Export disorders for ASB11 gene to outside databases
|
Publications for ASB11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASB11 gene integrated from 9 sources: (articles sorted by number of sources associating them with ASB11) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The novel gene asb11: a regulator of the size of the neural progenitor compartment. (PubMed id 16893969)1 Diks S.H....Zivkovic D. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1 Kile B.T....Hilton D.J. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for ASB11 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ASB11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASB11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASB11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ASB11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ASB11 gene: Search GeneIP for patents involving ASB11
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ASB11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for ASB11 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASB11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASB11 | | OriGene Protein Over-expression Lysate for ASB11 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ASB11 | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASB11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASB11 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | Search Tocris compounds for ASB11 |
| |  |  |  |  | | | | |
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 | | ASB11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB11 |
|  |  |  |  | | | ThermoFisher Antibodies for ASB11 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB11 |
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