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Aliases for ASB11 Gene

Aliases for ASB11 Gene

  • Ankyrin Repeat And SOCS Box Containing 11 2 3 5
  • Ankyrin Repeat And SOCS Box Containing 11, E3 Ubiquitin Protein Ligase 2 3
  • ASB-11 3 4
  • Ankyrin Repeat Domain-Containing SOCS Box Protein ASB11 3
  • Ankyrin Repeat And SOCS Box-Containing 11 2
  • Ankyrin Repeat And SOCS Box Protein 11 3

External Ids for ASB11 Gene

Previous GeneCards Identifiers for ASB11 Gene

  • GC0XM014746
  • GC0XM014127
  • GC0XM014503
  • GC0XM014663
  • GC0XM014661
  • GC0XM015061
  • GC0XM015211
  • GC0XM013060

Summaries for ASB11 Gene

Entrez Gene Summary for ASB11 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for ASB11 Gene

ASB11 (Ankyrin Repeat And SOCS Box Containing 11) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.

UniProtKB/Swiss-Prot for ASB11 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB11 Gene

Genomics for ASB11 Gene

Regulatory Elements for ASB11 Gene

Enhancers for ASB11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF015333 1.1 FANTOM5 ENCODE 14.6 -19.7 -19656 2.9 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BRCA1 ZNF2 YY1 GLIS2 PIGA ASB11 ZRSR2 CA5B PIR MOSPD2 GC0XM015327
GH0XF015356 0.2 ENCODE 12.4 -41.0 -40977 0.1 HLF CEBPB FOXP2 PIGA ASB11 BMX PIR ACE2 GS1-594A7.3 VEGFD
GH0XF015298 1 Ensembl ENCODE 9.3 +16.5 16466 2.0 SCRT1 CTCF ZNF654 RAD21 ATF2 GABPA YY1 HNF1A SCRT2 SMC3 ASB9 PIGA ASB11
GH0XF015300 0.2 ENCODE 8.9 +15.3 15334 0.2 CTCF HNF1A ZNF654 SMC3 RAD21 ATF2 YY1 PIGA ASB11 ASB9
GH0XF015309 0.8 ENCODE 8.8 +4.9 4866 2.3 MEF2D GATA3 RNF2 ZBTB20 ASB11 ASB9
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ASB11 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB11 Gene

Chromosome:
X
Start:
15,275,644 bp from pter
End:
15,315,667 bp from pter
Size:
40,024 bases
Orientation:
Minus strand

Genomic View for ASB11 Gene

Genes around ASB11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB11 Gene

Proteins for ASB11 Gene

  • Protein details for ASB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXH4-ASB11_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 11
    Protein Accession:
    Q8WXH4
    Secondary Accessions:
    • E9PEN1
    • Q3SYC4
    • Q7Z667

    Protein attributes for ASB11 Gene

    Size:
    323 amino acids
    Molecular mass:
    35367 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ASB11 Gene

    Alternative splice isoforms for ASB11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASB11 Gene

Post-translational modifications for ASB11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB11 Gene

No data available for DME Specific Peptides for ASB11 Gene

Domains & Families for ASB11 Gene

Gene Families for ASB11 Gene

Suggested Antigen Peptide Sequences for ASB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXH4

UniProtKB/Swiss-Prot:

ASB11_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 6 ANK repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ASB11: view

Function for ASB11 Gene

Molecular function for ASB11 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with ASB11: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASB11 Gene

Localization for ASB11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB11 Gene COMPARTMENTS Subcellular localization image for ASB11 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ASB11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB11 Gene

Pathways & Interactions for ASB11 Gene

genes like me logo Genes that share pathways with ASB11: view

UniProtKB/Swiss-Prot Q8WXH4-ASB11_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB11: view

No data available for SIGNOR curated interactions for ASB11 Gene

Transcripts for ASB11 Gene

mRNA/cDNA for ASB11 Gene

(7) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB11 Gene

Ankyrin repeat and SOCS box containing 11:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: -

Relevant External Links for ASB11 Gene

GeneLoc Exon Structure for
ASB11
ECgene alternative splicing isoforms for
ASB11

Expression for ASB11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASB11 Gene

mRNA differential expression in normal tissues according to GTEx for ASB11 Gene

This gene is overexpressed in Heart - Left Ventricle (x20.3), Muscle - Skeletal (x19.7), and Heart - Atrial Appendage (x9.6).

Protein differential expression in normal tissues from HIPED for ASB11 Gene

This gene is overexpressed in Tonsil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ASB11 Gene



Protein tissue co-expression partners for ASB11 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASB11 Gene:

ASB11

SOURCE GeneReport for Unigene cluster for ASB11 Gene:

Hs.352183
genes like me logo Genes that share expression patterns with ASB11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ASB11 Gene

Orthologs for ASB11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB11 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB11 34 35
  • 90.2 (n)
cow
(Bos Taurus)
Mammalia ASB11 34 35
  • 88.34 (n)
rat
(Rattus norvegicus)
Mammalia Asb11 34
  • 86.31 (n)
mouse
(Mus musculus)
Mammalia Asb11 34 16 35
  • 84.54 (n)
oppossum
(Monodelphis domestica)
Mammalia ASB11 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB11 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB11 34 35
  • 72.46 (n)
lizard
(Anolis carolinensis)
Reptilia ASB11 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb11 34
  • 65.94 (n)
zebrafish
(Danio rerio)
Actinopterygii asb11 35
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4234 35
  • 30 (a)
OneToMany
Species where no ortholog for ASB11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB11 Gene

ENSEMBL:
Gene Tree for ASB11 (if available)
TreeFam:
Gene Tree for ASB11 (if available)

Paralogs for ASB11 Gene

Variants for ASB11 Gene

Sequence variations from dbSNP and Humsavar for ASB11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs11094674 -- 15,307,311(+) GGTTT(A/C)TATAA intron-variant
rs111394800 -- 15,290,283(+) CAAGA(A/C)CCAGA intron-variant
rs111452972 -- 15,283,584(+) CGAGA(C/T)ACTTC reference, missense
rs112078885 -- 15,311,662(+) GCCCT(C/T)TTTTT intron-variant
rs112173368 -- 15,294,612(+) ATGAC(A/C)CTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB11 Gene

Variant ID Type Subtype PubMed ID
nsv517938 CNV gain 19592680
nsv522729 CNV gain 19592680
nsv528343 CNV gain 19592680

Variation tolerance for ASB11 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB11 Gene

Disorders for ASB11 Gene

Relevant External Links for ASB11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB11

No disorders were found for ASB11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB11 Gene

Publications for ASB11 Gene

  1. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 4 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for ASB11 Gene

Sources for ASB11 Gene

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