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Aliases for ASB10 Gene

Aliases for ASB10 Gene

  • Ankyrin Repeat And SOCS Box Containing 10 2 3
  • GLC1F 3 6
  • Ankyrin Repeat And SOCS Box-Containing 10 2
  • Glaucoma 1, Open Angle, F (Adult-Onset) 2
  • Ankyrin Repeat And SOCS Box Protein 10 3
  • ASB-10 4

External Ids for ASB10 Gene

Previous HGNC Symbols for ASB10 Gene

  • GLC1F

Previous GeneCards Identifiers for ASB10 Gene

  • GC07M149119
  • GC07M150187
  • GC07M150264
  • GC07M150310
  • GC07M150503
  • GC07M150872
  • GC07M144683

Summaries for ASB10 Gene

Entrez Gene Summary for ASB10 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for ASB10 Gene

ASB10 (Ankyrin Repeat And SOCS Box Containing 10) is a Protein Coding gene. Diseases associated with ASB10 include glaucoma 1, open angle, f and open-angle glaucoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB18.

UniProtKB/Swiss-Prot for ASB10 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB10 Gene

Genomics for ASB10 Gene

Regulatory Elements for ASB10 Gene

Genomic Location for ASB10 Gene

151,175,698 bp from pter
151,187,832 bp from pter
12,135 bases
Minus strand

Genomic View for ASB10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB10 Gene

Proteins for ASB10 Gene

  • Protein details for ASB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat and SOCS box protein 10
    Protein Accession:
    Secondary Accessions:
    • A0AVH0
    • Q6ZUL6

    Protein attributes for ASB10 Gene

    467 amino acids
    Molecular mass:
    50894 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ASB10 Gene


neXtProt entry for ASB10 Gene

Proteomics data for ASB10 Gene at MOPED

Post-translational modifications for ASB10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASB10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB10 Gene

Domains for ASB10 Gene

Gene Families for ASB10 Gene

  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB10 Gene

Suggested Antigen Peptide Sequences for ASB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WXI3
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 7 ANK repeats.
genes like me logo Genes that share domains with ASB10: view

Function for ASB10 Gene

Molecular function for ASB10 Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASB10: view

Phenotypes for ASB10 Gene

GenomeRNAi human phenotypes for ASB10:
genes like me logo Genes that share phenotypes with ASB10: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASB10 Gene

Localization for ASB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASB10 Gene

Cytoplasm. Nucleus. Note=In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells.

Subcellular locations from

Jensen Localization Image for ASB10 Gene COMPARTMENTS Subcellular localization image for ASB10 gene
Compartment Confidence
extracellular 3
cytosol 2
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ASB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22156576
GO:0005737 cytoplasm IDA 22156576
genes like me logo Genes that share ontologies with ASB10: view

Pathways for ASB10 Gene

genes like me logo Genes that share pathways with ASB10: view

UniProtKB/Swiss-Prot Q8WXI3-ASB10_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ASB10: view

Transcripts for ASB10 Gene

mRNA/cDNA for ASB10 Gene

Unigene Clusters for ASB10 Gene

Ankyrin repeat and SOCS box containing 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASB10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ASB10
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASB10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP3: -
SP4: - -

Relevant External Links for ASB10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASB10 Gene

mRNA expression in normal human tissues for ASB10 Gene

mRNA differential expression in normal tissues according to GTEx for ASB10 Gene

This gene is overexpressed in Muscle - Skeletal (27.3), Heart - Left Ventricle (17.2), and Heart - Atrial Appendage (6.1).

SOURCE GeneReport for Unigene cluster for ASB10 Gene Hs.647081

mRNA Expression by UniProt/SwissProt for ASB10 Gene

Tissue specificity: Expressed in the eye. The highest expression is observed in the iris, with moderate levels in the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina, and choroid; and very low levels in the lens.
genes like me logo Genes that share expressions with ASB10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for ASB10 Gene

Orthologs for ASB10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ASB10 35
  • 99.57 (n)
  • 99.36 (a)
ASB10 36
  • 91 (a)
(Bos Taurus)
Mammalia ASB10 36
  • 89 (a)
(Canis familiaris)
Mammalia ASB10 36
  • 90 (a)
(Mus musculus)
Mammalia Asb10 35
  • 84.3 (n)
  • 83.94 (a)
Asb10 16
Asb10 36
  • 84 (a)
(Monodelphis domestica)
Mammalia ASB10 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia ASB10 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Asb10 35
  • 83.44 (n)
  • 83.23 (a)
(Gallus gallus)
Aves ASB10 36
  • 45 (a)
(Danio rerio)
Actinopterygii asb10 36
  • 45 (a)
Species with no ortholog for ASB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB10 Gene

Gene Tree for ASB10 (if available)
Gene Tree for ASB10 (if available)

Paralogs for ASB10 Gene

Paralogs for ASB10 Gene

Selected SIMAP similar genes for ASB10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ASB10: view

Variants for ASB10 Gene

Sequence variations from dbSNP and Humsavar for ASB10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs45917 -- 151,179,757(-) CTGGG(A/T)CCCCA intron-variant
rs310597 -- 151,175,959(+) AGGCC(A/G)TGGAC utr-variant-3-prime, downstream-variant-500B
rs310598 -- 151,176,521(+) TTGGG(A/G)CCAGG intron-variant
rs310599 -- 151,177,100(+) cacat(A/C)tgcat intron-variant
rs310600 -- 151,178,623(+) CTAGC(A/G)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB10 Gene

Variant ID Type Subtype PubMed ID
nsv889476 CNV Loss 21882294
dgv7545n71 CNV Loss 21882294
nsv831188 CNV Loss 17160897

Relevant External Links for ASB10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB10 Gene

Disorders for ASB10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ASB10 Gene including...

Search for ASB10 Gene in MalaCards »

(1) OMIM Diseases for ASB10 Gene (615054)


  • Glaucoma 1, open angle, F (GLC1F) [MIM:603383]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269 PubMed:22156576}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ASB10 Gene

genes like me logo Genes that share disorders with ASB10: view

Publications for ASB10 Gene

  1. Variants in ASB10 are associated with open-angle glaucoma. (PMID: 22156576) Pasutto F. … Wirtz M.K. (Hum. Mol. Genet. 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ASB10 Gene

Sources for ASB10 Gene

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