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ASB10 Gene

protein-coding   GIFtS: 49
GCID: GC07M150872

Ankyrin Repeat And SOCS Box Containing 10

(Previous names: ankyrin repeat and SOCS box-containing 10, glaucoma 1, open...)
(Previous symbol: GLC1F)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ankyrin Repeat And SOCS Box Containing 101 2
GLC1F1 2 5
Glaucoma 1, Open Angle, F (Adult-Onset)1 2
Ankyrin Repeat And SOCS Box-Containing 101
Ankyrin Repeat And SOCS Box Protein 102
ASB-103

External Ids:    HGNC: 171851   Entrez Gene: 1363712   Ensembl: ENSG000001469267   OMIM: 6150545   UniProtKB: Q8WXI33   

Export aliases for ASB10 gene to outside databases

Previous GC identifers: GC07M149119 GC07M150187 GC07M150264 GC07M150310 GC07M150503 GC07M144683


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASB10 Gene:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of
proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding
partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively
spliced transcript variants have been described for this gene. (provided by RefSeq, Dec 2008)

GeneCards Summary for ASB10 Gene:
ASB10 (ankyrin repeat and SOCS box containing 10) is a protein-coding gene. Diseases associated with ASB10 include glaucoma 1, open angle, f, and open-angle glaucoma. An important paralog of this gene is ASB16.

UniProtKB/Swiss-Prot: ASB10_HUMAN, Q8WXI3
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ASB10 gene promoter:
         POU2F1   POU2F1a   c-Myb   USF2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ASB10 promoter sequence
   Search Chromatin IP Primers for ASB10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q35

ASB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASB10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150872:  view genomic region     (about GC identifiers)

Start:
150,872,785 bp from pter      End:
150,884,919 bp from pter
Size:
12,135 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,202,306-150,214,439     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASB10_HUMAN, Q8WXI3 (See protein sequence)
Recommended Name: Ankyrin repeat and SOCS box protein 10  
Size: 467 amino acids; 50894 Da
Secondary accessions: A0AVH0 Q6ZUL6
Alternative splicing: 3 isoforms:  Q8WXI3-1   Q8WXI3-2   Q8WXI3-3   (Variant in position: 19:P->S (in GLC1F, uncertain pathological significance). Variant in position: 32:R->S (in GLC1F, uncertain pathological significance). Variant in position: 39:R->Q (in GLC1F, uncertain pathological significance))

Explore the universe of human proteins at neXtProt for ASB10: NX_Q8WXI3

Explore proteomics data for ASB10 at MOPED


See ASB10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001135931.2  NP_001135932.2  NP_543147.2  

ENSEMBL proteins: 
 ENSP00000275838   ENSP00000367098   ENSP00000391137   ENSP00000410871   ENSP00000401369  
 ENSP00000398247  
Reactome Protein details: Q8WXI3

ASB10 Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for ASB10


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ANKRD: Ankyrin repeat domain containing

3 InterPro protein domains:
 IPR002110 Ankyrin_rpt
 IPR001496 SOCS_C
 IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q8WXI3

ProtoNet protein and cluster: Q8WXI3

2 Blocks protein domains:
IPB001496 SOCS protein
IPB002110 Ankyrin repeat signature


UniProtKB/Swiss-Prot: ASB10_HUMAN, Q8WXI3
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
E3 ubiquitin-protein ligase complexes (By similarity)
Similarity: Contains 7 ANK repeats
Similarity: Contains 1 SOCS box domain


ASB10 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ASB10_HUMAN, Q8WXI3
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
ASB10 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for ASB10:
 Increased cell death HMECs cel  Synthetic lethal with Ras 

     1 MGI phenotypic allele for Asb10 (no phenotypes)

ASB10 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASB10
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miRNA
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hsa-miR-370
SwitchGear 3'UTR luciferase reporter plasmidASB10 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ASB10

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GenScript: all cDNA clones in your preferred vector (see all 3): ASB10 (NM_080871)
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ASB10_HUMAN, Q8WXI3: Cytoplasm. Nucleus. Note=In the ciliary body, it is detected in the cytoplasm and
perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of
retinal ganglion cells
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytosol2
lysosome1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005737cytoplasm IDA--

ASB10 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ASB10 About    
See pathways by source

SuperPathContained pathways About
1Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ASB10
    Antigen processing: Ubiquitination & Proteasome degradation


UniProtKB/Swiss-Prot: ASB10_HUMAN, Q8WXI3
Pathway: Protein modification; protein ubiquitination


ASB10 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASB10
Interactions:

    Search GeneGlobe Interaction Network for ASB10

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for ASB10 (ENSP000004013694) via UniProtKB, MINT, STRING, and/or I2D

InteractantInteraction Details
GeneCardExternal ID(s)
AGR3ENSP000003086064STRING: ENSP00000308606
ARFGAP1ENSP000003146154STRING: ENSP00000314615
MRPL23ENSP000003709304STRING: ENSP00000370930
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IEA--
GO:0035556intracellular signal transduction IEA--

ASB10 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ASB10



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ASB10 gene (3 alternative transcripts): 
NM_001142459.1  NM_001142460.1  NM_080871.3  

Unigene Cluster for ASB10:

Ankyrin repeat and SOCS box containing 10
Hs.647081  [show with all ESTs]
Unigene Representative Sequence: NM_001142459
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000275838 ENST00000377867(uc003wjn.1) ENST00000420175 ENST00000415615
ENST00000422024(uc003wjm.1) ENST00000434669(uc003wjl.1)
miRNA
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Block miRNA regulation of human, mouse, rat ASB10 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate ASB10:
hsa-miR-370
SwitchGear 3'UTR luciferase reporter plasmidASB10 3' UTR sequence
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat ASB10
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GenScript: all cDNA clones in your preferred vector (see all 3): ASB10 (NM_080871)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASB10
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASB10
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for ASB10
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ASB10
  QuantiTect SYBR Green Assays in human, mouse, rat ASB10
  QuantiFast Probe-based Assays in human, mouse, rat ASB10

Additional mRNA sequence: 

AF417920.1 AK055536.1 AK125565.1 AK315114.1 BC126351.1 

4 DOTS entries:

DT.97807259  DT.65286974  DT.101963834  DT.121116557 

19 AceView cDNA sequences:

CD636003 AK055536 CD635987 NM_080871 CD635999 AK125565 CD636001 CD636008 
CD636006 CD636009 CD635993 CD635991 F29396 AF417920 CD635995 CD635989 
CD635997 CD635985 F34490 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ASB10    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:              -     -     -     -     -                                 
SP2:                                                                        
SP3:                                                        -               
SP4:                    -     -                                             


ECgene alternative splicing isoforms for ASB10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ASB10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ASB10 Expression
About this image

ASB10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ASB10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.647081

UniProtKB/Swiss-Prot: ASB10_HUMAN, Q8WXI3
Tissue specificity: Expressed in the eye. The highest expression is observed in the iris, with moderate levels in
the trabecular meshwork (TM), the lamina, and the optic nerve; slightly lower levels in the ciliary body, retina,
and choroid; and very low levels in the lens

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASB10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ASB10 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Asb101 , 5 ankyrin repeat and SOCS box-containing 101, 5 84.3(n)1
83.94(a)1
  5 (11.93 cM)5
1175901  NM_080444.41  NP_536692.11 
 245326975 
chicken
(Gallus gallus)
Aves ASB106
ankyrin repeat and SOCS box containing 10
45(a)
1 ↔ 1
2(153467-159923)
zebrafish
(Danio rerio)
Actinopterygii asb106
ankyrin repeat and SOCS box containing 10
45(a)
1 ↔ 1
24(35444283-35465953) ENSDARG00000071419


ENSEMBL Gene Tree for ASB10 (if available)
TreeFam Gene Tree for ASB10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ASB10 gene
ASB162  ASB182  ASB42  
5 SIMAP similar genes for ASB10 using alignment to 4 protein entries:     ASB10_HUMAN (see all proteins):
PPP1R12A    ASB18    GABPB1    ASB16    ASB4

ASB10 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ASB10 (see all 401)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1048864861,2
C,Funtested1154325398(-) AGGTCG/ACTGCA 6 /S syn13Minor allele frequency- A:0.01NA EU 4945
rs1513446121,2
Cuntested1154330118(-) CGTCCA/GTGTCT 6 H R mis10--------
rs1048864841,2
Cuntested1154330119(-) CCGTCC/TGTGTC 6 R C mis11Minor allele frequency- T:0.00NA 3136
rs1048864831,2
Cuntested1154330151(-) GCACGC/TGGTTC 6 A V mis10--------
rs617344071,2
C,Funtested1154330173(+) GGCCAG/AGGCTG 6 /L syn13Minor allele frequency- A:0.00NS NA EU 4559
rs1048864811,2
C,Funtested1154330211(-) ACACAC/TGCCCC 6 T M mis12Minor allele frequency- T:0.00NA EU 5095
rs1513446101,2
Cuntested1154330239(-) TCAGCA/GCCAAC 6 T A mis10--------
rs617351301,2
C,Funtested1154330287(+) GCCACG/AGCGGC 6 /R /C mis13Minor allele frequency- A:0.00NS NA EU 4743
rs1513446091,2
Cuntested1154330313(-) CAAGCA/TGCGAC 6 Q L mis10--------
rs1406029731,2
Cuntested1154330382(+) GGCAGC/TGGGCG 6 H R mis11Minor allele frequency- T:0.00NA 4154

HapMap Linkage Disequilibrium report for ASB10 (150872785 - 150884919 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for ASB10:    About this table    
Variant IDTypeSubtypePubMed ID
nsv831188CNV Loss17160897
dgv7545n71CNV Loss21882294
nsv889476CNV Loss21882294

Human Gene Mutation Database (HGMD): ASB10
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing ASB10
DNA2.0 Custom Variant and Variant Library Synthesis for ASB10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 615054   
OMIM disorders: 603383  
UniProtKB/Swiss-Prot: ASB10_HUMAN, Q8WXI3
  • Glaucoma 1, open angle, F (GLC1F) [MIM:603383]: A form of primary open angle glaucoma (POAG). POAG is
    characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of
    the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any
    intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and
    irreversible optic nerve damage has already taken place. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 4 diseases for ASB10:    
    About MalaCards
    glaucoma 1, open angle, f    open-angle glaucoma    primary open angle glaucoma    glaucoma

    1 disease from the University of Copenhagen DISEASES database for ASB10:
    Primary open angle glaucoma

    ASB10 for disorders           About GeneDecksing


    Export disorders for ASB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASB10 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ASB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variants in ASB10 are associated with open-angle glaucoma. (PubMed id 22156576)1, 2, 3 Pasutto F....Wirtz M.K. (Hum. Mol. Genet. 2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    5. Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells. (PubMed id 23901248)1 Keller K.E....Wirtz M.K. (Mol. Vis. 2013)
    6. Analysis of ASB10 variants in open angle glaucoma. (PubMed id 22798626)1 Fingert J.H....Alward W.L. (Hum. Mol. Genet. 2012)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PubMed id 16325183)1 Kohroki J.... Masuho Y. (FEBS Lett. 2005)
    10. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (Science 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 136371 HGNC: 17185 AceView: ASB10 Ensembl:ENSG00000146926 euGenes: HUgn136371
    ECgene: ASB10 H-InvDB: ASB10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASB10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASB10 gene:
    Search GeneIP for patents involving ASB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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