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Aliases for ASB1 Gene

Aliases for ASB1 Gene

  • Ankyrin Repeat And SOCS Box Containing 1 2 3
  • Ankyrin Repeat And SOCS Box-Containing 1 2 3
  • ASB-1 3 4
  • Ankyrin Repeat And SOCS Box Protein 1 3
  • KIAA1146 4

External Ids for ASB1 Gene

Summaries for ASB1 Gene

Entrez Gene Summary for ASB1 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASB1 Gene

ASB1 (Ankyrin Repeat And SOCS Box Containing 1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB5.

UniProtKB/Swiss-Prot for ASB1 Gene

  • May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for ASB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB1 Gene

Genomics for ASB1 Gene

Genomic Location for ASB1 Gene

Start:
238,426,741 bp from pter
End:
238,452,250 bp from pter
Size:
25,510 bases
Orientation:
Plus strand

Genomic View for ASB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB1 Gene

Regulatory Elements for ASB1 Gene

Proteins for ASB1 Gene

  • Protein details for ASB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y576-ASB1_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 1
    Protein Accession:
    Q9Y576
    Secondary Accessions:
    • A6NL50
    • Q4ZG29
    • Q9ULS4

    Protein attributes for ASB1 Gene

    Size:
    335 amino acids
    Molecular mass:
    37014 Da
    Quaternary structure:
    • Interacts with CUL5 and RNF7.

neXtProt entry for ASB1 Gene

Proteomics data for ASB1 Gene at MOPED

Post-translational modifications for ASB1 Gene

  • Ubiquitination at Lys21 and Lys69

Other Protein References for ASB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB1 Gene

Domains for ASB1 Gene

Gene Families for ASB1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for ASB1 Gene

Suggested Antigen Peptide Sequences for ASB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y576

UniProtKB/Swiss-Prot:

ASB1_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.:
    • Q9Y576
  • Contains 1 SOCS box domain.:
    • Q9Y576
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.:
    • Q9Y576
Similarity:
  • Contains 6 ANK repeats.:
    • Q9Y576
genes like me logo Genes that share domains with ASB1: view

Function for ASB1 Gene

Molecular function for ASB1 Gene

UniProtKB/Swiss-Prot Function: May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for ASB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ASB1: view
genes like me logo Genes that share phenotypes with ASB1: view

miRNA for ASB1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ASB1 Gene

Localization for ASB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB1 Gene COMPARTMENTS Subcellular localization image for ASB1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ASB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IC 11111040
genes like me logo Genes that share ontologies with ASB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ASB1 Gene

Pathways for ASB1 Gene

genes like me logo Genes that share pathways with ASB1: view

UniProtKB/Swiss-Prot Q9Y576-ASB1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ASB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0030539 male genitalia development IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0042036 negative regulation of cytokine biosynthetic process NAS 11111040
genes like me logo Genes that share ontologies with ASB1: view

Transcripts for ASB1 Gene

mRNA/cDNA for ASB1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB1 Gene

Ankyrin repeat and SOCS box containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7
SP1: -
SP2: - - - -
SP3: -
SP4: - -
SP5:
SP6: - - -

Relevant External Links for ASB1 Gene

GeneLoc Exon Structure for
ASB1
ECgene alternative splicing isoforms for
ASB1

Expression for ASB1 Gene

mRNA expression in normal human tissues for ASB1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASB1 Gene

SOURCE GeneReport for Unigene cluster for ASB1 Gene Hs.516788

genes like me logo Genes that share expressions with ASB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ASB1 Gene

Orthologs for ASB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASB1 35
  • 99.5 (n)
  • 100 (a)
ASB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ASB1 35
  • 87.35 (n)
  • 96.08 (a)
ASB1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASB1 36
  • 96 (a)
OneToOne
LOC486182 35
  • 90.24 (n)
  • 95.64 (a)
mouse
(Mus musculus)
Mammalia Asb1 35
  • 86.97 (n)
  • 94.03 (a)
Asb1 16
Asb1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASB1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb1 35
  • 87.16 (n)
  • 94.63 (a)
chicken
(Gallus gallus)
Aves ASB1 35
  • 75.32 (n)
  • 81.49 (a)
ASB1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb1 35
  • 61.79 (n)
  • 62.62 (a)
zebrafish
(Danio rerio)
Actinopterygii asb1 35
  • 63.67 (n)
  • 60.68 (a)
asb1 36
  • 59 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for ASB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB1 Gene

ENSEMBL:
Gene Tree for ASB1 (if available)
TreeFam:
Gene Tree for ASB1 (if available)

Paralogs for ASB1 Gene

Paralogs for ASB1 Gene

Selected SIMAP similar genes for ASB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ASB1: view

Variants for ASB1 Gene

Sequence variations from dbSNP and Humsavar for ASB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9057 -- 238,435,779(+) GGCCA(C/T)TGCAG reference, missense, intron-variant, nc-transcript-variant
rs9941 -- 238,452,091(+) TGTTC(C/T)GTGGG utr-variant-3-prime, nc-transcript-variant
rs472357 -- 238,446,813(+) GAGGC(C/T)TACTA utr-variant-3-prime, nc-transcript-variant
rs473651 -- 238,426,760(+) AGGCA(A/C)CGGGC upstream-variant-2KB, utr-variant-5-prime, nc-transcript-variant
rs474478 -- 238,426,832(-) TCGCG(A/G)CTAAC upstream-variant-2KB, utr-variant-5-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB1 Gene

Variant ID Type Subtype PubMed ID
nsv876068 CNV Loss 21882294
nsv876069 CNV Gain 21882294
esv2721767 CNV Deletion 23290073
esv2721768 CNV Deletion 23290073
esv2721769 CNV Deletion 23290073

Relevant External Links for ASB1 Gene

HapMap Linkage Disequilibrium report
ASB1
Human Gene Mutation Database (HGMD)
ASB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB1 Gene

Disorders for ASB1 Gene

Relevant External Links for ASB1

Genetic Association Database (GAD)
ASB1
Human Genome Epidemiology (HuGE) Navigator
ASB1
genes like me logo Genes that share disorders with ASB1: view

No data available for UniProtKB/Swiss-Prot for ASB1 Gene

Publications for ASB1 Gene

  1. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PMID: 11111040) Kile B.T. … Alexander W.S. (Gene 2000) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. (PMID: 16325183) Kohroki J. … Masuho Y. (FEBS Lett. 2005) 3 4
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  5. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3 48

Products for ASB1 Gene

Sources for ASB1 Gene

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