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Aliases for ASB1 Gene

Aliases for ASB1 Gene

  • Ankyrin Repeat And SOCS Box Containing 1 2 3 5
  • Ankyrin Repeat And SOCS Box-Containing 1 2 3
  • ASB-1 3 4
  • KIAA1146 4

External Ids for ASB1 Gene

Previous GeneCards Identifiers for ASB1 Gene

  • GC02P237384
  • GC02P238017
  • GC02P239352
  • GC02P239622
  • GC02P239117
  • GC02P239000
  • GC02P231126

Summaries for ASB1 Gene

Entrez Gene Summary for ASB1 Gene

  • The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ASB1 Gene

ASB1 (Ankyrin Repeat And SOCS Box Containing 1) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. An important paralog of this gene is ASB7.

UniProtKB/Swiss-Prot for ASB1 Gene

  • May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for ASB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASB1 Gene

Genomics for ASB1 Gene

Regulatory Elements for ASB1 Gene

Enhancers for ASB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ASB1 on UCSC Golden Path with GeneCards custom track

Promoters for ASB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ASB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ASB1 Gene

Chromosome:
2
Start:
238,426,741 bp from pter
End:
238,452,250 bp from pter
Size:
25,510 bases
Orientation:
Plus strand

Genomic View for ASB1 Gene

Genes around ASB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASB1 Gene

Proteins for ASB1 Gene

  • Protein details for ASB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y576-ASB1_HUMAN
    Recommended name:
    Ankyrin repeat and SOCS box protein 1
    Protein Accession:
    Q9Y576
    Secondary Accessions:
    • A6NL50
    • Q4ZG29
    • Q9ULS4

    Protein attributes for ASB1 Gene

    Size:
    335 amino acids
    Molecular mass:
    37014 Da
    Quaternary structure:
    • Interacts with CUL5 and RNF7.

neXtProt entry for ASB1 Gene

Proteomics data for ASB1 Gene at MOPED

Post-translational modifications for ASB1 Gene

  • Ubiquitination at Lys 21 and Lys 69
  • Modification sites at PhosphoSitePlus

Other Protein References for ASB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ASB1 Gene

Domains & Families for ASB1 Gene

Gene Families for ASB1 Gene

Protein Domains for ASB1 Gene

Suggested Antigen Peptide Sequences for ASB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y576

UniProtKB/Swiss-Prot:

ASB1_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Belongs to the ankyrin SOCS box (ASB) family.
  • Contains 6 ANK repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the ankyrin SOCS box (ASB) family.
Similarity:
  • Contains 6 ANK repeats.
genes like me logo Genes that share domains with ASB1: view

Function for ASB1 Gene

Molecular function for ASB1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with ASB1: view

Animal Models for ASB1 Gene

MGI Knock Outs for ASB1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ASB1 Gene

Localization for ASB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASB1 Gene COMPARTMENTS Subcellular localization image for ASB1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASB1 Gene

Pathways & Interactions for ASB1 Gene

genes like me logo Genes that share pathways with ASB1: view

UniProtKB/Swiss-Prot Q9Y576-ASB1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ASB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042036 negative regulation of cytokine biosynthetic process NAS 11111040
genes like me logo Genes that share ontologies with ASB1: view

No data available for SIGNOR curated interactions for ASB1 Gene

Drugs & Compounds for ASB1 Gene

No Compound Related Data Available

Transcripts for ASB1 Gene

mRNA/cDNA for ASB1 Gene

(10) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ASB1 Gene

Ankyrin repeat and SOCS box containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASB1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7
SP1: -
SP2: - - - -
SP3: -
SP4: - -
SP5:
SP6: - - -

Relevant External Links for ASB1 Gene

GeneLoc Exon Structure for
ASB1
ECgene alternative splicing isoforms for
ASB1

Expression for ASB1 Gene

mRNA expression in normal human tissues for ASB1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASB1 Gene



SOURCE GeneReport for Unigene cluster for ASB1 Gene Hs.516788

genes like me logo Genes that share expression patterns with ASB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ASB1 Gene

Orthologs for ASB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ASB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASB1 35
  • 87.35 (n)
  • 96.08 (a)
ASB1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC486182 35
  • 90.24 (n)
  • 95.64 (a)
ASB1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Asb1 35
  • 86.97 (n)
  • 94.03 (a)
Asb1 16
Asb1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASB1 35
  • 99.5 (n)
  • 100 (a)
ASB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Asb1 35
  • 87.16 (n)
  • 94.63 (a)
oppossum
(Monodelphis domestica)
Mammalia ASB1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASB1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASB1 35
  • 75.32 (n)
  • 81.49 (a)
ASB1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASB1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asb1 35
  • 61.79 (n)
  • 62.62 (a)
zebrafish
(Danio rerio)
Actinopterygii asb1 35
  • 63.67 (n)
  • 60.68 (a)
asb1 36
  • 59 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for ASB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASB1 Gene

ENSEMBL:
Gene Tree for ASB1 (if available)
TreeFam:
Gene Tree for ASB1 (if available)

Paralogs for ASB1 Gene

Paralogs for ASB1 Gene

(2) SIMAP similar genes for ASB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ASB1: view

Variants for ASB1 Gene

Sequence variations from dbSNP and Humsavar for ASB1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs472357 -- 238,446,813(+) GAGGC(C/T)TACTA nc-transcript-variant, utr-variant-3-prime
rs473651 -- 238,426,760(+) AGGCA(A/C)CGGGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs474478 -- 238,426,832(-) TCGCG(A/G)CTAAC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs477041 -- 238,447,354(+) TGCAG(C/G)GAGTC nc-transcript-variant, utr-variant-3-prime
rs479384 -- 238,429,955(-) gtact(C/T)ggttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASB1 Gene

Variant ID Type Subtype PubMed ID
nsv876068 CNV Loss 21882294
nsv876069 CNV Gain 21882294
esv2721767 CNV Deletion 23290073
esv2721768 CNV Deletion 23290073
esv2721769 CNV Deletion 23290073

Variation tolerance for ASB1 Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASB1 Gene

Human Gene Mutation Database (HGMD)
ASB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASB1 Gene

Disorders for ASB1 Gene

Relevant External Links for ASB1

Genetic Association Database (GAD)
ASB1
Human Genome Epidemiology (HuGE) Navigator
ASB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASB1

No disorders were found for ASB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASB1 Gene

Publications for ASB1 Gene

  1. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. (PMID: 11111040) Kile B.T. … Alexander W.S. (Gene 2000) 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3
  4. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for ASB1 Gene

Sources for ASB1 Gene

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