Aliases for ASB1 Gene
External Ids for ASB1 Gene
Previous GeneCards Identifiers for ASB1 Gene
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ASB1 Gene
ASB1 (Ankyrin Repeat And SOCS Box Containing 1) is a Protein Coding gene. Diseases associated with ASB1 include cellulitis. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is ASB5.
UniProtKB/Swiss-Prot for ASB1 Gene
May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.