Aliases for ASB1 Gene
External Ids for ASB1 Gene
Previous GeneCards Identifiers for ASB1 Gene
The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016]
GeneCards Summary for ASB1 Gene
ASB1 (Ankyrin Repeat And SOCS Box Containing 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ASB12.
UniProtKB/Swiss-Prot for ASB1 Gene
May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.