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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ASAP3 Gene

protein-coding GIFtS: 49
GCID: GC01M023755

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

(Previous name: development and differentiation enhancing factor-like 1...)
(Previous symbol: DDEFL1)

Explore 4 diseases affiliated with
ASAP3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3¹ ²		FLJ20199¹
DDEFL1¹ ² ³		ACAP4²
UPLC1¹ ² ³		Arf-GAP With SH3 Domain, ANK Repeat And PH Domain-Containing Protein 3²
CENTB6¹ ²		ARF6 GTPase-Activating Protein²
Development And Differentiation Enhancing Factor-Like 1¹ ²		ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3 1²
Development And Differentiation-Enhancing Factor-Like 1² ³		Centaurin, Beta 6²
Protein Up-Regulated In Liver Cancer 1² ³		Up-Regulated In Liver Cancer 1 (UPLC1)²

External Ids:	HGNC: 14987¹	Entrez Gene: 55616²	Ensembl: ENSG00000088280⁷	UniProtKB: Q8TDY4³

Export aliases for ASAP3 gene to outside databases

Previous GC identifers: GC01M023628 GC01M022006

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ASAP3:

This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain

additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis

of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated

in cancer cell invasion. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: ASAP3_HUMAN, Q8TDY4

Function: Promotes cell proliferation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for ASAP3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ASAP3 promoter sequence

Search SABiosciences Chromatin IP Primers for ASAP3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASAP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.13

ASAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASAP3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M023755: view genomic region (about GC identifiers)

Start:	23,755,055 bp from pter	End:	23,810,750 bp from pter
Size:	55,696 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ASAP3_HUMAN, Q8TDY4 (See protein sequence)

Recommended Name: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Size: 903 amino acids; 99155 Da

Subcellular location: Cytoplasm

3 PDB 3D structures from and Proteopedia for ASAP3:

2B0O (3D)

3LVQ (3D)

3LVR (3D)

Secondary accessions: B3KRW0 B4DHH4 Q6P9F4 Q86UY1 Q9NXK2

Alternative splicing: 3 isoforms: Q8TDY4-1 Q8TDY4-2 Q8TDY4-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASAP3: NX_Q8TDY4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TDY4

ASAP3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001137250.1 NP_060177.2

ENSEMBL proteins:

ENSP00000431715 ENSP00000436150 ENSP00000338769 ENSP00000435394 ENSP00000435858

ENSP00000408826 ENSP00000434897 ENSP00000436439

Human Recombinant Protein Products for ASAP3:

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	Novus Biologicals ASAP3 Protein Novus Biologicals ASAP3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

ASAP3 for ontologies About GeneDecksing

ASAP3 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ASAP3 for domains About GeneDecksing

5 InterPro domains/families:

IPR001849 Pleckstrin_homology

IPR001164 ArfGAP

IPR020683 Ankyrin_rpt-contain_dom

IPR011993 PH_like_dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q8TDY4

ProtoNet protein and cluster: Q8TDY4

3 Blocks protein families:

IPB001164 HIV Rev interacting protein signature

IPB001849 Pleckstrin-like

IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: ASAP3_HUMAN, Q8TDY4

Similarity: Contains 2 ANK repeats

Similarity: Contains 1 Arf-GAP domain

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ASAP3_HUMAN, Q8TDY4

Function: Promotes cell proliferation

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005543	phospholipid binding	IEA	--
GO:0008060	ARF GTPase activator activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0019904	protein domain specific binding	IEA	--

ASAP3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ASAP3:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ASAP3

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ASAP3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASAP3
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ASAP3 (see all 10):
		hsa-miR-219-1-3p hsa-miR-200c* hsa-miR-3918 hsa-miR-550a* hsa-miR-3667-3p hsa-miR-146a* hsa-miR-1184 hsa-miR-550b

		SwitchGear 3'UTR luciferase reporter plasmid: ASAP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASAP3 OriGene shRNA RFP: ASAP3 OriGene siRNA: ASAP3
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ASAP3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ASAP3
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASAP3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASAP3 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASAP3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Endocytosis

Endocytosis

1.00

Fc gamma R-mediated phagocytosis

Fc gamma R-mediated phagocytosis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Kegg Pathways (Kegg details for ASAP3):

	Endocytosis
	Fc gamma R-mediated phagocytosis

ASAP3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ASAP3

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ASAP3 (Q8TDY4³ ENSP00000338769⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CRK	P46108³, ENSP00000300574⁴	I2D: score=1 STRING: ENSP00000300574
ARF6	P62330³, ENSP00000298316⁴	I2D: score=1 STRING: ENSP00000298316

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032312	regulation of ARF GTPase activity	IEA	--

ASAP3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ASAP3
Search CenterWatch for drugs/clinical trials and news about ASAP3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ASAP3 gene (2 alternative transcripts):

NM_001143778.1 NM_017707.3

Unigene Cluster for ASAP3:

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

Hs.437379 [show with all ESTs]

Unigene Representative Sequence: NM_017707

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000485644(uc001bhc.1) ENST00000495646(uc001bgy.1) ENST00000484906

ENST00000336689(uc010odz.1 uc001bha.2 uc010oea.1) ENST00000465372

ENST00000492982 ENST00000437606 ENST00000484418 ENST00000475814 ENST00000530874

ENST00000478858 ENST00000449467

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ASAP3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ASAP3
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ASAP3 (see all 10):
		hsa-miR-219-1-3p hsa-miR-200c* hsa-miR-3918 hsa-miR-550a* hsa-miR-3667-3p hsa-miR-146a* hsa-miR-1184 hsa-miR-550b

		SwitchGear 3'UTR luciferase reporter plasmid: ASAP3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASAP3 OriGene shRNA RFP: ASAP3 OriGene siRNA: ASAP3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASAP3
		Sirion Biotech Custom design and validation of potent shRNA sequences against ASAP3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASAP3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASAP3 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AB056749.1 AK000206.1 AK000253.1 AK074319.1 AK092291.1 AK295100.1 AK299359.1 BC052305.1

BC060786.1

11 DOTS entries:

DT.455364 DT.102830236 DT.100787644 DT.121446283 DT.100787645 DT.100787642 DT.100787643 DT.121446274

DT.121446306 DT.91884185 DT.95150905

24/126 AceView cDNA sequences (see all 126):

CD655321 AX747456 NM_017707 BG911880 AI223205 BX479307 BQ934512 AI197864

BX482605 AK092291 BC023519 F01775 Z39902 BF725242 BM977407 BQ942741

BQ887741 CR609624 AB056749 BI829043 BQ646678 CB216506 BQ772467 BQ893008

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ASAP3 (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19a	·
SP1:																																	-
SP2:			-		-																-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:																															-		-
SP4:									-
SP5:

ExUns:	19b	·	19c	^	20	^	21	^	22a	·	22b	^	23a	·	23b	·	23c	^	24a	·	24b	^	25a	·	25b	^	26	^	27
SP1:	-		-												-		-
SP2:	-		-		-		-		-		-		-		-		-		-		-		-
SP3:
SP4:
SP5:	-		-

ECgene alternative splicing isoforms for ASAP3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ASAP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ASAP3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ASAP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASAP3

SOURCE GeneReport for Unigene cluster: Hs.437379

UniProtKB/Swiss-Prot: ASAP3_HUMAN, Q8TDY4

Tissue specificity: Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes

SABiosciences Custom PCR Arrays for ASAP3

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASAP3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASAP3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ASAP3 gene from 5/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ASAP3⁶	--	65(a)	1 ↔ 1	GL343904.1(3647-37167)
zebrafish (Danio rerio)	Actinopterygii	asap3⁶	ArfGAP with SH3 domain, ankyrin repeat and PH doma...	48(a)	1 ↔ 1	17(27033011-27077487)
fruit fly (Drosophila melanogaster)	Insecta	Asap1⁶	ArfGAP with SH3 domain, ankyrin repeat and PH doma...	27(a)	possible ortholog	2R(4001791-4010357)
thale cress (Arabidopsis thaliana)	eudicotyledons	SFC⁶ AGD2⁶ (see all 4)	ADP-ribosylation factor GTPase-activating protein ... ADP-ribosylation factor GTPase-activating protein ... (see all 4)	18(a) 17(a) (see all 4)	many ↔ many many ↔ many (see all 4)	5(4255601-4262314) 1(22400927-22407777)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	SFC, putative, expressed (see all 3)	17(a) 16(a) (see all 3)	many ↔ many many ↔ many (see all 3)	9(19823228-19830851) 8(26868563-26877272)

ENSEMBL Gene Tree for ASAP3 (if available)
TreeFam Gene Tree for ASAP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ASAP3 gene

AGAP5² AGAP6² ASAP1² ACAP2² ARAP3² GIT2² ACAP3² ARAP1²

ASAP2² AGAP3² GIT1² ARAP2² AGAP2² AGAP4² AGAP1² AGAP8²

ACAP1² AGAP7² AGAP10² AGAP9²

4 SIMAP similar genes for ASAP3 using alignment to 6 protein entries: ASAP3_HUMAN (see all proteins):

DDEF2 ASAP1 ASAP2 ARFGAP1

ASAP3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143703096^1,2		--	23754576(+)	`CTTTCC/TGTTTC`	2	--	ds500¹		0	--	--	--	--
rs113196978^1,2	C,F	--	23754741(+)	`TTCCAG/AGGTTT`	2	--	ds500¹		4		WA CSA	124
rs7520038^1,2	C,F,H	--	23754822(+)	`AGGATG/ATTTAG`	2	--	ds500¹		15		NS EA NA	1932
rs113239822^1,2		--	23754917(+)	`TTCCCC/TGGGGC`	2	--	ds500¹		2		CSA WA	120
rs112695530^1,2		--	23755036(+)	`AGATCA/GCATAA`	2	--	ds500¹		2		CSA NA	122
rs35871963^1,2	F	--	23755095(+)	`AAATAA/GCAAGT`	2	--	ut3¹		1		WA	118
rs115006058^1,2		--	23755269(+)	`CCTGCC/TAGGGC`	2	--	ut3¹		1		WA	118
rs76254456^1,2	C,F	--	23755293(+)	`ACTGGC/TAAGTT`	2	--	ut3¹		1		WA	118
rs190362960^1,2		--	23755344(+)	`TCTCAC/TTGGGG`	2	--	ut3¹		0	--	--	--	--
rs182941290^1,2		--	23755416(+)	`TTCTAC/TTACTC`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ASAP3 (23755055 - 23810750 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ASAP3
1 CNV: 58372

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASAP3

DNA2.0 Custom Variant and Variant Library Synthesis for ASAP3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ASAP3 for disorders About GeneDecksing

4 diseases for ASAP3: About MalaCards

liver cancer hepatocellular carcinoma carcinoma malaria

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ASAP3 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ASAP3)

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Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas. (PubMed id 14654939)^{1, 2, 3} Okabe H.... Nakamura Y. (2004)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
ACAP4 protein cooperates with Grb2 protein to orchestr ate epidermal growth factor-stimulated integrin b1 recycling in cell migration. (PubMed id 22027826)¹ Yu X....Yao X. (2011)
The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism. (PubMed id 20510928)¹ Ismail S.A....Wittinghofer A. (2010)
Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)¹ Brehme M....Superti-Furga G. (2009)
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome. (PubMed id 18685082)¹ Inoue H....Randazzo P.A. (2008)
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. (PubMed id 18400762)¹ Ha V.L....Randazzo P.A. (2008)
Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4. (PubMed id 16737952)¹ Fang Z....Yao X. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55616	HGNC: 14987	AceView: UPLC1	Ensembl:ENSG00000088280	euGenes: HUgn55616
ECgene: ASAP3	Kegg: 55616	H-InvDB: ASAP3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ASAP3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ASAP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ASAP3 gene:
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ASAP3 Gene

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

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ASAP3 Gene

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

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