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Aliases for ASAP3 Gene

Aliases for ASAP3 Gene

  • ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3 2 3
  • Development And Differentiation Enhancing Factor-Like 1 2 3
  • Development And Differentiation-Enhancing Factor-Like 1 3 4
  • Protein Up-Regulated In Liver Cancer 1 3 4
  • DDEFL1 3 4
  • UPLC1 3 4
  • ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3 1 3
  • Up-Regulated In Liver Cancer 1 (UPLC1) 3
  • ARF6 GTPase-Activating Protein 3
  • Centaurin, Beta 6 3
  • Centaurin 2
  • Beta 6 2
  • CENTB6 3
  • ACAP4 3

External Ids for ASAP3 Gene

Previous HGNC Symbols for ASAP3 Gene

  • DDEFL1

Previous GeneCards Identifiers for ASAP3 Gene

  • GC01M023628
  • GC01M023755
  • GC01M022006

Summaries for ASAP3 Gene

Entrez Gene Summary for ASAP3 Gene

  • This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for ASAP3 Gene

ASAP3 (ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3) is a Protein Coding gene. Among its related pathways are Endocytosis and Fc gamma R-mediated phagocytosis. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is AGAP2.

UniProtKB/Swiss-Prot for ASAP3 Gene

  • Promotes cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASAP3 Gene

Genomics for ASAP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ASAP3 Gene

Chromosome:
1
Start:
23,428,563 bp from pter
End:
23,484,568 bp from pter
Size:
56,006 bases
Orientation:
Minus strand

Genomic View for ASAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASAP3 Gene

No data available for Regulatory Elements for ASAP3 Gene

Proteins for ASAP3 Gene

  • Protein details for ASAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDY4-ASAP3_HUMAN
    Recommended name:
    Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
    Protein Accession:
    Q8TDY4
    Secondary Accessions:
    • B3KRW0
    • B4DHH4
    • Q6P9F4
    • Q86UY1
    • Q9NXK2

    Protein attributes for ASAP3 Gene

    Size:
    903 amino acids
    Molecular mass:
    99155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ASAP3 Gene

    Alternative splice isoforms for ASAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASAP3 Gene

Proteomics data for ASAP3 Gene at MOPED

Post-translational modifications for ASAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ASAP3 Gene

Domains & Families for ASAP3 Gene

Suggested Antigen Peptide Sequences for ASAP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDY4

UniProtKB/Swiss-Prot:

ASAP3_HUMAN :
  • Contains 1 Arf-GAP domain.
  • Contains 2 ANK repeats.
Domain:
  • Contains 1 Arf-GAP domain.
  • Contains 1 PH domain.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with ASAP3: view

Function for ASAP3 Gene

Molecular function for ASAP3 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation.

Gene Ontology (GO) - Molecular Function for ASAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 18400762
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ASAP3: view
genes like me logo Genes that share phenotypes with ASAP3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ASAP3 Gene

Localization for ASAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASAP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ASAP3 Gene COMPARTMENTS Subcellular localization image for ASAP3 gene
Compartment Confidence
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ASAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 18400762
GO:0005737 cytoplasm IEA --
GO:0005925 focal adhesion IDA 18400762
genes like me logo Genes that share ontologies with ASAP3: view

Pathways & Interactions for ASAP3 Gene

genes like me logo Genes that share pathways with ASAP3: view

Pathways by source for ASAP3 Gene

2 KEGG pathways for ASAP3 Gene

Gene Ontology (GO) - Biological Process for ASAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IMP 18400762
GO:0043547 positive regulation of GTPase activity IDA 18400762
GO:0051492 regulation of stress fiber assembly IMP 18400762
genes like me logo Genes that share ontologies with ASAP3: view

No data available for SIGNOR curated interactions for ASAP3 Gene

Drugs & Compounds for ASAP3 Gene

No Compound Related Data Available

Transcripts for ASAP3 Gene

Unigene Clusters for ASAP3 Gene

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ASAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASAP3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 19b · 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27
SP1: - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: - - -

Relevant External Links for ASAP3 Gene

GeneLoc Exon Structure for
ASAP3
ECgene alternative splicing isoforms for
ASAP3

Expression for ASAP3 Gene

mRNA expression in normal human tissues for ASAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ASAP3 Gene

This gene is overexpressed in Placenta (12.8), Urine (7.9), Pancreas (7.6), and Fetal testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ASAP3 Gene



SOURCE GeneReport for Unigene cluster for ASAP3 Gene Hs.437379

mRNA Expression by UniProt/SwissProt for ASAP3 Gene

Q8TDY4-ASAP3_HUMAN
Tissue specificity: Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.
genes like me logo Genes that share expression patterns with ASAP3: view

Protein tissue co-expression partners for ASAP3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ASAP3 Gene

Orthologs for ASAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASAP3 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Asap3 36
  • 82 (a)
OneToOne
Asap3 16
Asap3 35
  • 82.54 (n)
  • 81.35 (a)
dog
(Canis familiaris)
Mammalia ASAP3 36
  • 96 (a)
OneToOne
ASAP3 35
  • 88.32 (n)
  • 86.68 (a)
cow
(Bos Taurus)
Mammalia ASAP3 36
  • 88 (a)
OneToOne
ASAP3 35
  • 90.31 (n)
  • 92.77 (a)
rat
(Rattus norvegicus)
Mammalia LOC684122 35
  • 81.84 (n)
  • 79.3 (a)
chimpanzee
(Pan troglodytes)
Mammalia ASAP3 35
  • 98.9 (n)
  • 99.2 (a)
chicken
(Gallus gallus)
Aves ASAP3 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASAP3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asap3 35
  • 58.34 (n)
  • 54.66 (a)
zebrafish
(Danio rerio)
Actinopterygii asap3 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Asap1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5006 36
  • 29 (a)
OneToMany
Species with no ortholog for ASAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASAP3 Gene

ENSEMBL:
Gene Tree for ASAP3 (if available)
TreeFam:
Gene Tree for ASAP3 (if available)

Paralogs for ASAP3 Gene

(4) SIMAP similar genes for ASAP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ASAP3: view

Variants for ASAP3 Gene

Sequence variations from dbSNP and Humsavar for ASAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs112044381 -- 23,459,478(+) TAAAC(-/CAAT)CAGAT intron-variant
rs111915263 -- 23,456,331(+) GGAAC(G/T)TATCC intron-variant
rs111826031 -- 23,485,369(+) AAAAG(-/A)AAAAG upstream-variant-2KB
rs111798250 -- 23,483,174(+) GAAGG(A/G)TGGAA intron-variant
rs111756457 -- 23,454,200(+) TTTTT(G/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASAP3 Gene

Variant ID Type Subtype PubMed ID
nsv834435 CNV Loss 17160897
nsv819574 CNV Gain 19587683

Variation tolerance for ASAP3 Gene

Residual Variation Intolerance Score: 46.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASAP3 Gene

HapMap Linkage Disequilibrium report
ASAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASAP3 Gene

Disorders for ASAP3 Gene

Relevant External Links for ASAP3

Genetic Association Database (GAD)
ASAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASAP3
genes like me logo Genes that share disorders with ASAP3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASAP3 Gene

Publications for ASAP3 Gene

  1. Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas. (PMID: 14654939) Okabe H. … Nakamura Y. (Int. J. Oncol. 2004) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. ASAP3 expression in non-small cell lung cancer: association with cancer development and patients' clinical outcome. (PMID: 24078447) Fan C. … Wang E. (Tumour Biol. 2014) 67
  4. Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration. (PMID: 24284654) Luo Y. … Yang J.Y. (Mol Med Rep 2014) 67
  5. Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation. (PMID: 23776207) Zhao X. … Yao X. (Proc. Natl. Acad. Sci. U.S.A. 2013) 67

Products for ASAP3 Gene

Sources for ASAP3 Gene

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