Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ASAP3 Gene

Aliases for ASAP3 Gene

  • ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3 2 3 5
  • Development And Differentiation Enhancing Factor-Like 1 2 3
  • Protein Up-Regulated In Liver Cancer 1 3 4
  • Centaurin, Beta 6 2 3
  • DDEFL1 3 4
  • UPLC1 3 4
  • Arf-GAP With SH3 Domain, ANK Repeat And PH Domain-Containing Protein 3 3
  • ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3 1 3
  • Development And Differentiation-Enhancing Factor-Like 1 4
  • Up-Regulated In Liver Cancer 1 (UPLC1) 3
  • ARF6 GTPase-Activating Protein 3
  • CENTB6 3
  • ACAP4 3

External Ids for ASAP3 Gene

Previous HGNC Symbols for ASAP3 Gene

  • DDEFL1

Previous GeneCards Identifiers for ASAP3 Gene

  • GC01M023628
  • GC01M023755
  • GC01M022006

Summaries for ASAP3 Gene

Entrez Gene Summary for ASAP3 Gene

  • This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

GeneCards Summary for ASAP3 Gene

ASAP3 (ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3) is a Protein Coding gene. Among its related pathways are Fc gamma R-mediated phagocytosis and Endocytosis. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ASAP2.

UniProtKB/Swiss-Prot for ASAP3 Gene

  • Promotes cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASAP3 Gene

Genomics for ASAP3 Gene

Regulatory Elements for ASAP3 Gene

Enhancers for ASAP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F023471 1.4 Ensembl ENCODE 33.5 +10.2 10210 4.9 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ASAP3 ZNF436-AS1 ZNF436 TCEA3 GC01P023474 GC01P023475
GH01F023478 1.3 Ensembl ENCODE 34.7 +5.2 5208 1.3 PKNOX1 ATF1 CREB3L1 ARID4B DMAP1 YY1 SP5 NFYC MXD4 NCOA1 ASAP3 ELOA ZBTB40-IT1 GC01M023474
GH01F023420 1 ENCODE 43.2 +61.4 61371 5.1 HDGF ATF1 CREB3L1 MLX ARID4B DMAP1 ZNF2 ZNF48 YY1 ZNF143 ASAP3 ZNF436-AS1 TCEA3 ENSG00000201405 ZNF436 ENSG00000232482
GH01F023451 1.4 Ensembl ENCODE 30.8 +32.2 32216 2.3 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF766 ASAP3 LINC01355 RPL11 PNRC2 GC01P023453 GC01M023439
GH01F023482 1.1 ENCODE 35.4 +0.2 243 2.9 HDGF PKNOX1 ARNT CREB3L1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF766 ASAP3 ZNF436 TCEA3 GC01M023474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ASAP3 on UCSC Golden Path with GeneCards custom track

Promoters for ASAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000280256 568 2401 HDGF PKNOX1 ARNT CREB3L1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF766

Genomic Location for ASAP3 Gene

Chromosome:
1
Start:
23,428,563 bp from pter
End:
23,484,568 bp from pter
Size:
56,006 bases
Orientation:
Minus strand

Genomic View for ASAP3 Gene

Genes around ASAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASAP3 Gene

Proteins for ASAP3 Gene

  • Protein details for ASAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDY4-ASAP3_HUMAN
    Recommended name:
    Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
    Protein Accession:
    Q8TDY4
    Secondary Accessions:
    • B3KRW0
    • B4DHH4
    • Q6P9F4
    • Q86UY1
    • Q9NXK2

    Protein attributes for ASAP3 Gene

    Size:
    903 amino acids
    Molecular mass:
    99155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ASAP3 Gene

    Alternative splice isoforms for ASAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ASAP3 Gene

Post-translational modifications for ASAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ASAP3 Gene

Domains & Families for ASAP3 Gene

Suggested Antigen Peptide Sequences for ASAP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDY4

UniProtKB/Swiss-Prot:

ASAP3_HUMAN :
  • Contains 1 Arf-GAP domain.
  • Contains 2 ANK repeats.
Domain:
  • Contains 1 Arf-GAP domain.
  • Contains 1 PH domain.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with ASAP3: view

Function for ASAP3 Gene

Molecular function for ASAP3 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation.

Gene Ontology (GO) - Molecular Function for ASAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA,IDA 18400762
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ASAP3: view
genes like me logo Genes that share phenotypes with ASAP3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ASAP3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASAP3 Gene

Localization for ASAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ASAP3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ASAP3 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ASAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 18400762
GO:0005737 cytoplasm IEA --
GO:0005925 focal adhesion IEA,IDA 18400762
genes like me logo Genes that share ontologies with ASAP3: view

Pathways & Interactions for ASAP3 Gene

genes like me logo Genes that share pathways with ASAP3: view

Pathways by source for ASAP3 Gene

2 KEGG pathways for ASAP3 Gene

Gene Ontology (GO) - Biological Process for ASAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IEA,IMP 18400762
GO:0043547 positive regulation of GTPase activity IEA,IDA 18400762
GO:0051492 regulation of stress fiber assembly IMP 18400762
genes like me logo Genes that share ontologies with ASAP3: view

No data available for SIGNOR curated interactions for ASAP3 Gene

Transcripts for ASAP3 Gene

Unigene Clusters for ASAP3 Gene

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ASAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ASAP3 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 19b · 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27
SP1: - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: - - -

Relevant External Links for ASAP3 Gene

GeneLoc Exon Structure for
ASAP3
ECgene alternative splicing isoforms for
ASAP3

Expression for ASAP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ASAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ASAP3 Gene

This gene is overexpressed in Placenta (12.8), Urine (7.9), Pancreas (7.6), and Fetal testis (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ASAP3 Gene



Protein tissue co-expression partners for ASAP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ASAP3 Gene:

ASAP3

SOURCE GeneReport for Unigene cluster for ASAP3 Gene:

Hs.437379

mRNA Expression by UniProt/SwissProt for ASAP3 Gene:

Q8TDY4-ASAP3_HUMAN
Tissue specificity: Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes.
genes like me logo Genes that share expression patterns with ASAP3: view

Primer Products

No data available for mRNA differential expression in normal tissues for ASAP3 Gene

Orthologs for ASAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ASAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ASAP3 34
  • 98.9 (n)
cow
(Bos Taurus)
Mammalia ASAP3 34 35
  • 90.31 (n)
dog
(Canis familiaris)
Mammalia ASAP3 34 35
  • 88.32 (n)
mouse
(Mus musculus)
Mammalia Asap3 34 16 35
  • 82.54 (n)
rat
(Rattus norvegicus)
Mammalia LOC684122 34
  • 81.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ASAP3 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASAP3 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia asap3 34
  • 58.34 (n)
zebrafish
(Danio rerio)
Actinopterygii asap3 35
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Asap1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5006 35
  • 29 (a)
OneToMany
Species where no ortholog for ASAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ASAP3 Gene

ENSEMBL:
Gene Tree for ASAP3 (if available)
TreeFam:
Gene Tree for ASAP3 (if available)

Paralogs for ASAP3 Gene

(4) SIMAP similar genes for ASAP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ASAP3: view

Variants for ASAP3 Gene

Sequence variations from dbSNP and Humsavar for ASAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035612 A colorectal cancer sample
rs10157661 -- 23,464,739(+) AGTCA(A/G)Agatt intron-variant
rs10157662 -- 23,464,741(+) Tcaga(A/G)attct intron-variant
rs10157666 -- 23,464,796(+) tgtta(A/G)aaaag intron-variant
rs10157667 -- 23,464,822(+) aatca(A/G)aaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ASAP3 Gene

Variant ID Type Subtype PubMed ID
nsv834435 CNV loss 17160897
nsv819574 CNV gain 19587683
nsv1130950 CNV deletion 24896259
nsv1075332 CNV deletion 25765185
esv3585483 CNV loss 21293372
esv3326511 CNV duplication 20981092

Variation tolerance for ASAP3 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ASAP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ASAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ASAP3 Gene

Disorders for ASAP3 Gene

Relevant External Links for ASAP3

Genetic Association Database (GAD)
ASAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ASAP3

No disorders were found for ASAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASAP3 Gene

Publications for ASAP3 Gene

  1. Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas. (PMID: 14654939) Okabe H. … Nakamura Y. (Int. J. Oncol. 2004) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ASAP3 Gene

Sources for ASAP3 Gene

Content
Loading form....