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ASAP3 Gene

protein-coding   GIFtS: 51
GCID: GC01M023755

ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3

(Previous name: development and differentiation enhancing factor-like 1)
(Previous symbol: DDEFL1)
  Search for ASAP3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 31 2     ACAP42
DDEFL11 2 3     CENTB62
Development And Differentiation Enhancing Factor-Like 11 2     Arf-GAP With SH3 Domain, ANK Repeat And PH Domain-Containing Protein 32
Development And Differentiation-Enhancing Factor-Like 12 3     ARF6 GTPase-Activating Protein2
Protein Up-Regulated In Liver Cancer 12 3     ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 3 12
UPLC12 3     Centaurin, Beta 62
Beta 61     Up-Regulated In Liver Cancer 1 (UPLC1)2
centaurin1     

External Ids:    HGNC: 149871   Entrez Gene: 556162   Ensembl: ENSG000000882807   UniProtKB: Q8TDY43   

Export aliases for ASAP3 gene to outside databases

Previous GC identifers: GC01M023628 GC01M022006


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ASAP3 Gene:
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain
additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the
hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has
been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. (provided
by RefSeq, Jan 2009)

GeneCards Summary for ASAP3 Gene:
ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and ARF GTPase activator activity. An important paralog of this gene is AGAP5.

UniProtKB/Swiss-Prot: ASAP3_HUMAN, Q8TDY4
Function: Promotes cell proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ASAP3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidASAP3 promoter sequence
   Search Chromatin IP Primers for ASAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ASAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.13

ASAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASAP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M023755:  view genomic region     (about GC identifiers)

Start:
23,755,056 bp from pter      End:
23,811,061 bp from pter
Size:
56,006 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ASAP3_HUMAN, Q8TDY4 (See protein sequence)
Recommended Name: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3  
Size: 903 amino acids; 99155 Da
3 PDB 3D structures from and Proteopedia for ASAP3:
2B0O (3D)        3LVQ (3D)        3LVR (3D)    
Secondary accessions: B3KRW0 B4DHH4 Q6P9F4 Q86UY1 Q9NXK2
Alternative splicing: 3 isoforms:  Q8TDY4-1   Q8TDY4-2   Q8TDY4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ASAP3: NX_Q8TDY4

Explore proteomics data for ASAP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ASAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137250.1  NP_060177.2  

    ENSEMBL proteins: 
     ENSP00000436150   ENSP00000338769   ENSP00000435394   ENSP00000435858   ENSP00000408826  
     ENSP00000434897   ENSP00000436439   ENSP00000476400  

    ASAP3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals ASAP3 Protein
    Novus Biologicals ASAP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ASAP3 

    ASAP3 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ASAP3

    ASAP3 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ASAP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ANKRD: Ankyrin repeat domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    Selected InterPro protein domains (see all 7):
     IPR027267 AH/BAR-dom
     IPR028775 ASAP3
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TDY4

    ProtoNet protein and cluster: Q8TDY4

    3 Blocks protein domains:
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ASAP3_HUMAN, Q8TDY4
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 1 PH domain


    Find genes that share domains with ASAP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ASAP3_HUMAN, Q8TDY4
    Function: Promotes cell proliferation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008060ARF GTPase activator activity IDA18400762
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ASAP3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ASAP3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ASAP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ASAP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ASAP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ASAP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ASAP3:
    hsa-mir-335-5p (MIRT018191)

    Block miRNA regulation of human, mouse, rat ASAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ASAP3 (see all 10):
    hsa-miR-219-1-3p hsa-miR-200c* hsa-miR-3918 hsa-miR-550a* hsa-miR-3667-3p hsa-miR-146a* hsa-miR-1184 hsa-miR-550b
    SwitchGear 3'UTR luciferase reporter plasmidASAP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ASAP3
    Predesigned siRNA for gene silencing in human, mouse, rat ASAP3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): ASAP3 (NM_017707)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASAP3
    Addgene plasmids for ASAP3 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASAP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ASAP3_HUMAN, Q8TDY4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IDA18400762
    GO:0005737cytoplasm IEA--
    GO:0005925focal adhesion IDA18400762

    Find genes that share ontologies with ASAP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ASAP3 About    
    See pathways by source

    SuperPathContained pathways About
    1Fc gamma R-mediated phagocytosis
    Fc gamma R-mediated phagocytosis
    2Endocytosis
    Endocytosis


    Find genes that share SuperPaths with ASAP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for ASAP3):
        Endocytosis
    Fc gamma R-mediated phagocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ASAP3
    Interactions:

        Search GeneGlobe Interaction Network for ASAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ASAP3 (Q8TDY43 ENSP000003387694) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    ARF6P623303, ENSP000002983164I2D: score=1 STRING: ENSP00000298316
    FA2HENSP000002193684STRING: ENSP00000219368
    ARFGAP1ENSP000003146154STRING: ENSP00000314615
    SACM1LENSP000003737134STRING: ENSP00000373713
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016477cell migration IMP18400762
    GO:0032312regulation of ARF GTPase activity ----
    GO:0032850positive regulation of ARF GTPase activity IDA18400762
    GO:0051492regulation of stress fiber assembly IMP18400762

    Find genes that share ontologies with ASAP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ASAP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ASAP3 gene (2 alternative transcripts): 
    NM_001143778.1  NM_017707.3  

    Unigene Cluster for ASAP3:

    ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
    Hs.437379  [show with all ESTs]
    Unigene Representative Sequence: NM_017707
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495646(uc001bgy.1) ENST00000336689(uc010odz.1 uc001bha.2 uc010oea.1)
    ENST00000465372 ENST00000492982 ENST00000437606 ENST00000484418 ENST00000475814
    ENST00000530874 ENST00000478858 ENST00000608765 ENST00000449467
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ASAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ASAP3 (see all 10):
    hsa-miR-219-1-3p hsa-miR-200c* hsa-miR-3918 hsa-miR-550a* hsa-miR-3667-3p hsa-miR-146a* hsa-miR-1184 hsa-miR-550b
    SwitchGear 3'UTR luciferase reporter plasmidASAP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ASAP3
    Predesigned siRNA for gene silencing in human, mouse, rat ASAP3
    Clone
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    OriGene ORF clones in mouse, rat for ASAP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ASAP3 (NM_017707)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ASAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ASAP3
    Addgene plasmids for ASAP3 
    Primer
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    OriGene qPCR primer pairs and template standards for ASAP3
    OriGene qSTAR qPCR primer pairs in human, mouse for ASAP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ASAP3
      QuantiTect SYBR Green Assays in human, mouse, rat ASAP3
      QuantiFast Probe-based Assays in human, mouse, rat ASAP3

    Additional mRNA sequence: 

    AB056749.1 AK000206.1 AK000253.1 AK074319.1 AK092291.1 AK295100.1 AK299359.1 BC052305.1 
    BC060786.1 

    11 DOTS entries:

    DT.455364  DT.102830236  DT.100787644  DT.121446283  DT.100787645  DT.100787642  DT.100787643  DT.121446274 
    DT.121446306  DT.91884185  DT.95150905 

    Selected AceView cDNA sequences (see all 126):

    BM977407 BQ942741 AK092291 BX479307 BC023519 AI197864 BQ934512 BX482605 
    AB056749 BI829043 NM_017707 AI223205 BG911880 CD655321 AX747456 F01775 
    Z39902 CR609624 BF725242 BQ887741 BM795773 F05509 BX119884 BP350892 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ASAP3 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
    SP1:                                                                                                  -                                                         
    SP2:        -     -                                               -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP3:                                                                                            -     -                                                         
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 19b · 19c ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27
    SP1:  -     -                                   -     -                                       
    SP2:  -     -     -     -     -     -     -     -     -     -     -     -                     
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:  -     -                                                                                 


    ECgene alternative splicing isoforms for ASAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ASAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ASAP3 Expression
    About this image


    ASAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
    ASAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ASAP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437379

    UniProtKB/Swiss-Prot: ASAP3_HUMAN, Q8TDY4
    Tissue specificity: Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes

        Custom PCR Arrays for ASAP3
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    QuantiFast Probe-based Assays in human, mouse, rat ASAP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ASAP3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Asap31 , 5 ArfGAP with SH3 domain, ankyrin repeat and PH domain more1, 5 82.54(n)1
    81.35(a)1
      4 (68.34 cM)5
    2308371  NM_001008232.21  NP_001008233.11 
     1362063655 
    chicken
    (Gallus gallus)
    Aves ASAP36
    ArfGAP with SH3 domain, ankyrin repeat and PH doma...
    68(a)
    1 ↔ 1
    23(2140634-2150231)
    lizard
    (Anolis carolinensis)
    Reptilia ASAP36
    ArfGAP with SH3 domain, ankyrin repeat and PH doma...
    65(a)
    1 ↔ 1
    GL343904.1(3647-37167)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia asap31 ArfGAP with SH3 domain, ankyrin repeat and PH domain more 58.34(n)
    54.66(a)
      100491007  XM_002939360.2  XP_002939406.2 
    zebrafish
    (Danio rerio)
    Actinopterygii asap36
    ArfGAP with SH3 domain, ankyrin repeat and PH doma...
    47(a)
    1 ↔ 1
    17(27033011-27077487) ENSDARG00000021896
    fruit fly
    (Drosophila melanogaster)
    Insecta Asap16
    ArfGAP with SH3 domain, ankyrin repeat and PH doma...
    29(a)
    1 → many
    2R(4001791-4010357)


    ENSEMBL Gene Tree for ASAP3 (if available)
    TreeFam Gene Tree for ASAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ASAP3 gene
    AGAP52  AGAP62  ASAP12  ARAP32  ACAP22  ACAP32  ASAP22  ARAP12  
    AGAP32  ARAP22  AGAP22  AGAP42  AGAP12  AGAP82  ACAP12  AGAP72  
    AGAP102  AGAP92  
    4 SIMAP similar genes for ASAP3 using alignment to 7 protein entries:     ASAP3_HUMAN (see all proteins):
    DDEF2    ASAP1    ASAP2    ARFGAP1

    Find genes that share paralogs with ASAP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ASAP3 (see all 1172)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356124
    A colorectal cancer sample4--see VAR_0356122 A T mis40--------
    rs1437030961,2
    C--23754576(+) CTTTCC/TGTTTC 2 -- ds50010--------
    rs1131969781,2
    C,F--23754741(+) TTCCAG/AGGTTT 2 -- ds50014Minor allele frequency- A:0.07WA CSA 124
    rs75200381,2
    C,F,H--23754822(+) AGGATG/ATTTAG 2 -- ds500115Minor allele frequency- A:0.12NS EA NA 1932
    rs1132398221,2
    F--23754917(+) TTCCCC/TGGGGC 2 -- ds50012Minor allele frequency- T:0.04CSA WA 120
    rs1126955301,2
    C,F--23755036(+) AGATCA/GCATAA 2 -- ds50012Minor allele frequency- G:0.04CSA NA 122
    rs358719631,2
    C,F--23755095(+) AAATAA/GCAAGT 2 -- ut311Minor allele frequency- G:0.03WA 118
    rs1150060581,2
    F--23755269(+) CCTGCC/TAGGGC 2 -- ut311Minor allele frequency- T:0.01WA 118
    rs762544561,2
    C,F--23755293(+) ACTGGC/TAAGTT 2 -- ut311Minor allele frequency- T:0.03WA 118
    rs1903629601,2
    C--23755344(+) TCTCAC/TTGGGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ASAP3 (23755056 - 23811061 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ASAP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834435CNV Loss17160897
    nsv819574CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ASAP3
    DNA2.0 Custom Variant and Variant Library Synthesis for ASAP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ASAP3           About GenesLikeMe

    Genetic Association Database (GAD): ASAP3

    Export disorders for ASAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ASAP3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ASAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas. (PubMed id 14654939)1, 2, 3 Okabe H.... Nakamura Y. (Int. J. Oncol. 2004)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation. (PubMed id 23776207)1 Zhao X....Yao X. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    6. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin I^1 recycling in cell migration. (PubMed id 22027826)1 Yu X....Yao X. (J. Biol. Chem. 2011)
    7. The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism. (PubMed id 20510928)1 Ismail S.A....Wittinghofer A. (Cell 2010)
    8. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    9. Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome. (PubMed id 18685082)1 Inoue H....Randazzo P.A. (Mol. Biol. Cell 2008)
    10. ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. (PubMed id 18400762)1 Ha V.L....Randazzo P.A. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55616 HGNC: 14987 AceView: UPLC1 Ensembl:ENSG00000088280 euGenes: HUgn55616
    ECgene: ASAP3 Kegg: 55616 H-InvDB: ASAP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ASAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ASAP3 gene:
    Search GeneIP for patents involving ASAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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