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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ASAP2 Gene

protein-coding   GIFtS: 59
GCID: GC02P009346

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

(Previous name: development and differentiation enhancing factor 2 )
(Previous symbol: DDEF2)
 Explore 6 diseases affiliated with
ASAP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ASAP2    

Aliases
for ASAP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 21 2     Paxillin-Associated Protein With ARF GAP Activity 32 3
DDEF21 2 3 5     Pyk2 C-Terminus-Associated Protein2 3
PAP1 2 3 5     PAG32 3
CENTB31 2     AMAP22
SHAG11 2     Pap-Alpha1
Development And Differentiation Enhancing Factor 21 2     Arf-GAP With SH3 Domain, ANK Repeat And PH Domain-Containing Protein 22
KIAA04001 3     Centaurin, Beta 32
Development And Differentiation-Enhancing Factor 22 3     PYK2 C Terminus-Associated Protein2

External Ids:    HGNC: 27211   Entrez Gene: 88532   Ensembl: ENSG000001516937   OMIM: 6038175   UniProtKB: O431503   

Export aliases for ASAP2 gene to outside databases

Previous GC identifers: GC02P009264 GC02P009193


Summaries
for ASAP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ASAP2:
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif,
followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region,
and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane,
where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2
in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of
PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II
ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed
to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition,
it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation
of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: ASAP2_HUMAN, O43150
Function: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates
constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to
focal contacts and cell migration

Gene Wiki entry for ASAP2 (DDEF2)


Genomic Views
for ASAP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005334.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ASAP2 gene promoter:
         RFX1   FOXD3   CUTL1   STAT5A   POU3F2   NF-kappaB   GATA-1   POU2F1   POU2F1a   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ASAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25|2p24   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p24

ASAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ASAP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P009346:  view genomic region     (about GC identifiers)

Start:
 9,346,894 bp from pter      End:
 9,545,812 bp from pter
Size:
 198,919 bases      Orientation:
 plus strand

Proteins
for ASAP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ASAP2_HUMAN, O43150 (See protein sequence)
Recommended Name: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2  
Size: 1006 amino acids; 111651 Da
Subunit: Binds PXN, ARF1, ARF5, ARF6, PTK2B and SRC
Subcellular location: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane;
Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups
Sequence caution: Sequence=BAA23696.2; Type=Erroneous initiation;
Secondary accessions: D6W4Y8
Alternative splicing: 2 isoforms:  O43150-1   O43150-2   

Explore the universe of human proteins at neXtProt for ASAP2: NX_O43150

Post-translational modifications:

  • Phosphorylated on tyrosine residues by SRC and PTK2B1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43150

    • ASAP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128663.1  NP_003878.1  

    ENSEMBL proteins: 
     ENSP00000281419   ENSP00000316404  

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    Novus Biologicals ASAP2 Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ASAP2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--


    ASAP2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ASAP2

    Protein Domains /
    Families
    for ASAP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ASAP2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR001452 SH3_domain
     IPR020683 Ankyrin_rpt-contain_dom
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O43150

    ProtoNet protein and cluster: O43150

    4 Blocks protein families:
    IPB001164 HIV Rev interacting protein signature
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like
    IPB002110 Ankyrin repeat signature


    UniProtKB/Swiss-Prot: ASAP2_HUMAN, O43150
    Domain: The conserved Arg-464 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and
    is necessary for GTP hydrolysis
    Similarity: Contains 2 ANK repeats
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH3 domain


    Function
    for ASAP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ASAP2_HUMAN, O43150
    Function: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates
    constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to
    focal contacts and cell migration
    Induction: Up-regulated during monocytic maturation

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate ASAP2 (see all 48):
    hsa-miR-520f hsa-miR-300 hsa-miR-4328 hsa-miR-548k hsa-miR-199a-3p hsa-miR-485-3p hsa-miR-29a hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ASAP2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005543phospholipid binding IEA--
    GO:0008047enzyme activator activity TAS9819391
    GO:0008060ARF GTPase activator activity IEA--
    GO:0008270zinc ion binding IEA--


    ASAP2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ASAP2:
     Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for ASAP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Arf6 trafficking events
    		Arf6 trafficking events1.00
    2Endocytosis
    		Endocytosis1.00
    3Fc gamma R-mediated phagocytosis
    		Fc gamma R-mediated phagocytosis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for ASAP2 
        Arf6 trafficking events


    2         Kegg Pathways  (Kegg details for ASAP2):
        Endocytosis
    Fc gamma R-mediated phagocytosis


    ASAP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ASAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for ASAP2 (O431501, 2, 3 ENSP000002814194) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741, 2, 3, ENSP000002440074EBI-310968,EBI-79387 MINT-8112435 I2D: score=3 STRING: ENSP00000244007
    PIK3R1P279862, 3, ENSP000002743354MINT-8111811 I2D: score=3 STRING: ENSP00000274335
    SH3KBP1Q96B972, 3, ENSP000003809214MINT-4300058 I2D: score=3 STRING: ENSP00000380921
    CBLBQ131912, 3, ENSP000002641224MINT-4300041 I2D: score=1 STRING: ENSP00000264122
    UBCP0CG482, 3, ENSP000003448184MINT-4299964 MINT-4299995 I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032312regulation of ARF GTPase activity IEA--
    GO:0043085positive regulation of catalytic activity TAS9819391


    ASAP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ASAP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ASAP2

    1 HMDB Compound for ASAP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about ASAP2 

    Transcripts
    for ASAP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ASAP2 gene (2 alternative transcripts): 
    NM_001135191.1  NM_003887.2  

    Unigene Cluster for ASAP2:

    ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
    Hs.555902  [show with all ESTs]
    Unigene Representative Sequence: NM_003887
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281419(uc002qzh.2) ENST00000471687 ENST00000491413 ENST00000484590
    ENST00000315273(uc002qzi.2)

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate ASAP2 (see all 48):
    hsa-miR-520f hsa-miR-300 hsa-miR-4328 hsa-miR-548k hsa-miR-199a-3p hsa-miR-485-3p hsa-miR-29a hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ASAP2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB007860.1 AK091121.1 AK123185.1 AK124900.1 BC063308.1 

    12 DOTS entries:

    DT.216312  DT.87007471  DT.100774013  DT.40213623  DT.91728245  DT.100774010  DT.92059657  DT.100774015 
    DT.121022109  DT.121022199  DT.70101858  DT.95206773 

    24/186 AceView cDNA sequences (see all 186):

    AA886715 BM054841 AW451462 AI143427 CB160529 BM054657 AW083020 AB007860 
    F11743 AI708030 BU172421 BU628454 AA343776 F06551 T06154 BM978959 
    BM676090 CD673250 BG925617 F04059 BQ002724 Z39513 BQ423127 AA709068 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ASAP2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                                -                 -                                                         
    SP2:                                                                                -                 -                                                     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28
    SP1:        -                           
    SP2:        -                           
    SP3:                                    
    SP4:                                    


    ECgene alternative splicing isoforms for ASAP2

    Expression
    for ASAP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ASAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ASAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ASAP2

    SOURCE GeneReport for Unigene cluster: Hs.555902

    UniProtKB/Swiss-Prot: ASAP2_HUMAN, O43150
    Tissue specificity: Detected in heart, brain, placenta, kidney, monocytes and pancreas

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    In Situ
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    Orthologs
    for ASAP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ASAP2 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ASAP21 ArfGAP with SH3 domain, ankyrin repeat and PH domain more 78.98(n)
    90.32(a)    		   768599  XM_001231631.2  XP_001231632.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ASAP26
    		 --
    		 87(a)
    		 1 ↔ 1
    		 1(148510641-148610871)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BG554458.12   -- 73.93(n)    BG554458.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.239322 Transcribed sequence with moderate similarity to protein more 72.17(n)    CD760178.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Asap16
    		 ArfGAP with SH3 domain, ankyrin repeat and PH doma...
    		 38(a)
    		 possible ortholog
    		 2R(4001791-4010357)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AGD26
    AGD46
    (see all 4)    		 ADP-ribosylation factor GTPase-activating protein ...
    ADP-ribosylation factor GTPase-activating protein ...
    (see all 4)    		 19(a)
    18(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 1(22400927-22407777)
    1(3616610-3623758)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 ARF GTPase-activating domain-containing protein, p...
    ARF GTPase-activating domain-containing protein, p...
    (see all 3)    		 18(a)
    18(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 9(19823228-19830851)
    2(25323314-25336072)


    ENSEMBL Gene Tree for ASAP2 (if available)
    TreeFam Gene Tree for ASAP2 (if available) 

    Paralogs
    for ASAP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ASAP2 gene
    AGAP52  AGAP62  ASAP12  ACAP22  ARAP32  GIT22  ACAP32  ARAP12  
    AGAP32  GIT12  ARAP22  AGAP22  AGAP42  AGAP12  AGAP82  ACAP12  
    AGAP72  AGAP102  AGAP92  ASAP32  
    4 SIMAP similar genes for ASAP2 using alignment to 1 protein entry:     ASAP2_HUMAN:
    DDEF2    ASAP1    ASAP3    ARFGAP1

    ASAP2 for paralogs           About GeneDecksing



    Genomic Variants
    for ASAP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3667 NCBI SNPs in ASAP2 are shown (see all 3667)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs67479461,2
    		C,F,A,H,--9191985(+) CCTCAT/CGTCAA 1 -- ds5001 tfbs39Minor allele frequency- C:0.07NS EA NA WA CSA 548
    rs18582681,2
    		C,--9194195(-) CAAGCT/CTCTTC 1 -- us2k13Minor allele frequency- C:0.07MN WA 304
    rs744781951,2
    		--9194235(+) CAGAGT/CCTGTG 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs344634221,2
    		C,F,--9194310(+) ACCCAT/CCAAAC 1 -- us2k15Minor allele frequency- C:0.27NA WA CSA 244
    rs731519011,2
    		C,F,--9194529(+) TGGGTG/TGGGGG 1 -- us2k13Minor allele frequency- T:0.13WA CSA 122
    rs751010121,2
    		C,F,--9194909(+) GATGGG/TTGAAT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1136001351,2
    		--9344991(+) GTAGGC/AAAGTT 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1906711711,2
    		--9345124(+) CAGCTA/TTGCAA 3 -- ds5001 us2k10--------
    rs1403239001,2
    		--9345274(+) TTAATC/GCTGTA 3 -- us2k1 ds50010--------
    rs1440900821,2
    		--9345275(+) TAATGC/TTGTAC 3 -- ds5001 us2k10--------

    HapMap Linkage Disequilibrium report for ASAP2 (9346894 - 9545812 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for ASAP2
         12 CNVs: 78419 78416 97763 78418 89467 89466 89464 78414 78417 72592 89465 78415
         2 Indels: 72588 97762

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    Disorders / Diseases
    for ASAP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ASAP2 for disorders           About GeneDecksing

    OMIM gene information: 603817    OMIM disorders: --

    6 diseases for ASAP2:    About MalaCards
    cri-du-chat syndrome    multiple sclerosis    breast cancer    malaria
    pancreatic cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for ASAP2:
    Cri-Du-Chat syndrome
    Human Genome Epidemiology (HuGE) Navigator: ASAP2 (1 document)

    Export disorders for ASAP2 gene to outside databases

    Publications
    for ASAP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ASAP2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with ASAP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new Pyk2 target protein with Arf-GAP activity. (PubMed id 10022920)1, 2, 3, 9 Andreev J.... Schlessinger J. (1999)
    2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
    3. A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. (PubMed id 10749932)1, 2, 9 Kondo A.... Sabe H. (2000)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP- ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages. (PubMed id 11304556)1, 2 Uchida H.... Sabe H. (2001)
    7. A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function. (PubMed id 15231847)1, 9 Hashimoto S....Sabe H. (2004)
    8. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    External Searches for ASAP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing ASAP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8853 HGNC: 2721 AceView: DDEF2 Ensembl:ENSG00000151693 euGenes: HUgn8853
    ECgene: ASAP2 Kegg: 8853 H-InvDB: ASAP2

    Other Databases showing ASAP2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0400

    Specialized Databases showing ASAP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ASAP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ASAP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ASAP2 gene:
    Search GeneIP for patents involving ASAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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