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Aliases & Descriptions for NAAA
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ASAHL 2 , 3 EC 3.5.1.- 3 PLT 2 , 3
Descriptions ASAH-like protein 2 , 3 Acid ceramidase-like protein 2 , 3 N-acylethanolamine acid amidase 2 N-acylethanolamine-hydrolyzing acid amidase 2 N-acylsphingosine amidohydrolase (acid ceramidase)-like 1 , 2 N-acylsphingosine amidohydrolase-like 3
Search outside databases for aliases for NAAA gene
Summaries for NAAA (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
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EntrezGene summary for NAAA : This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acidceramidase. Multiple transcript variants encoding different isoforms have been found for thisgene. [provided by RefSeq] UniProtKB/Swiss-Prot: NAAA_HUMAN, Q02083 Function : Degrades bioactive fatty acid amides to their corresponding acids, with the followingpreference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine =N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weakhydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine
Gene Wiki entry for NAAA (ASAHL)
Genomic Location for NAAA
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
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Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q21.1 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21.1 NAAA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M077050:
(about GC identifiers )
Start:
77,050,832 bp from pter
End:
77,081,190 bp from pter
Size:
30,359 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000004.10 NT_016354.18 Proteins for NAAA
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
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Abcam ,
Biochemical Assays by
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Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
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Cell Signaling Technology ,
Abcam ,
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UniProtKB/Swiss-Prot: NAAA_HUMAN, Q02083 (See
protein sequence )Recommended Name: N-acylethanolamine-hydrolyzing acid amidase precursor Size : 359 amino acids; 40066 Da
Subcellular location : Lysosome (Probable)
Secondary accessions : Q5KTF2 Q96EY2 Q9BRA8Alternative splicing : 3 isoforms : Q02083-1 Q02083-2 Q02083-3
Post-translational modifications:
N-glycosylated. Tunicamycin treatment causes a reduction in specific activity againstN-palmitoylethanolamine1
REFSEQ proteins (2 alternative transcripts):
NP_001035861.1 NP_055250.2 ENSEMBL proteins: ENSP00000382413 ENSP00000382420 ENSP00000286733 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for NAAA: Assays for NAAA:
Protein
Domains/ Families for NAAA(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q02083 ProtoNet protein and cluster: Q02083
1 Blocks protein family : IPB003199 Choloylglycine hydrolase UniProtKB/Swiss-Prot: NAAA_HUMAN, Q02083 Similarity : Belongs to the acid ceramidase family
Gene Function for NAAA
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001042402 Applied Biosystems Silencer ® siRNAs for NAAA Sigma-Aldrich siRNA for NAAA Sigma-Aldrich shRNA for NAAA Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001042402                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001042402                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001042402  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014435 UniProtKB/Swiss-Prot: NAAA_HUMAN, Q02083 Function : Degrades bioactive fatty acid amides to their corresponding acids, with the followingpreference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine =N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weakhydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine Enzyme regulation : Stimulated by DTT and Nonidet P-40Biophysicochemical properties : Kinetic parameters: KM=97 uM for N-palmitoylethanolamine; pHdependence: Optimum pH is 4.5 with N-palmitoylethanolamine as substrate; Enzyme Number (IUBMB): EC 3.5.1.-
2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND -- GO:0016787 hydrolase activity
IEA --
About this table
Pathways & Interactions for NAAA
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for NAAA 5/19 Interacting proteins for NAAA (ENSP00000286733 3 ) via UniProtKB, MINT, and/or STRING (see all 19
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006629 lipid metabolic process
IEA -- GO:0008150 biological_process
ND --
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Drugs & Compounds for NAAA (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for NAAA
Transcripts for NAAA(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
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ESTs according to GeneTide ,
exon structure from GeneLoc ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001042402 Sigma-Aldrich siRNA for NAAA Sigma-Aldrich shRNA for NAAA Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001042402 NM_014435
REFSEQ mRNAs for NAAA gene (2 alternative transcripts): NM_001042402.1 NM_014435.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001042402 NM_014435
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001042402                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001042402                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001042402  
Additional cDNA sequence: AB161353.1 AK024677.1 AK301132.1 AK309271.1 M92449.1
16 DOTS entries : DT.86857920 DT.109510 DT.91816216 DT.91959761 DT.211615 DT.40111879 DT.100738484 DT.121268169 DT.92426440 DT.95229006 DT.121268102 DT.95182109 DT.95288709 DT.95288708 DT.97840369 DT.99944948
24/140 AceView cDNA sequences (see all 140
):CA942081 AA426329 BM725506 AW518659 AI685903 AI348673 BM682907 AA995567 CK300406 BM847445 BM719630 AI697736 AA974051 BM726877 R09660 AI088304 BM682921 BQ430901 AI241573 BM678138 BE503233 BF725211 BQ051465 BM763257
Unigene Cluster for NAAA: N-acylethanolamine acid amidase Hs.437365 [show with all ESTs ] Unigene Representative Sequence: NM_014435 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NAAA (see all 7
) ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c SP1 :   -     -                               SP2 :   -     -                   -             SP3 :   -     -       -             -             SP4 :                         -   -           SP5 :                           -          
About this scheme ECgene alternative splicing isoforms for NAAA 3 Ensembl transcripts including schematic representations : ENST00000399490
ENST00000399497
ENST00000286733
Expression for NAAA
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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NAAA expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for NAAA 1 / 2
15 probe-sets matching NAAA gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TAATGGGAGTSOURCE GeneReport for Unigene cluster: Hs.437365 UniProtKB/Swiss-Prot: NAAA_HUMAN, Q02083 Tissue specificity : Expressed in numerous tissues, with highest levels in liver and kidney,followed by pancreas
Orthologs for NAAA
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for NAAA gene from 5/7 species (see all 7
)
About this table Species with no ortholog for NAAA ENSEMBL Gene Tree for NAAA Paralogs for NAAA (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for NAAA gene ASAH1 2
SNPs/Variants for NAAA (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for NAAA (up to first 250kb)
Disorders & Mutations for NAAA
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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and/or TGDB .)
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OMIM: 607469 Human Genome Epidemiology Navigator: NAAA (1 document)
Medical News for NAAA (Possibly Related Articles in
Doctor's Guide )
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--
Publications for NAAA (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/18 PubMed articles for NAAA gene (see all 18
): Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein. (PubMed id 10610717) 1, 2, 3, 4 Hong S.-B.... Schuchman E.H. (1999) A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta. (PubMed id 1446826) 2, 3, 4 Goodchild N.L....Mager D.L. (1992) Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. (PubMed id 15655246) 1, 3, 4 Tsuboi K.... Ueda N. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism. (PubMed id 17980170) 1, 3 Zhao L.Y....Ueda N. (2007) Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. (PubMed id 19014633) 1, 3 Muller T.D....Hinney A. (2008) Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells. (PubMed id 18806270) 1, 3 Wang J....Ueda N. (2008) Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218) 4 Chen R.... Zou H. (2009) Overexpression and mass spectrometry analysis of mature human acid ceramidase. (PubMed id 18020949) 3 Schulze H....Sandhoff K. (2007) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 3 Oh J.H....Kim N.S. (2005)
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Genome Databases showing NAAA
(According to
Entrez Gene ,
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Other Databases showing NAAA
(According to HUGE )
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Specialized Databases showing NAAA (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for NAAA (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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