ASAH2C Gene
protein-coding GIFtS: 31
GCID: GC10M047999
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N-acylsphingosine amidohydrolase (non-lysosomal ceramidase)...
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Aliases
for ASAH2C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2C1 2 | | BA98I6.31 | | EC 3.5.1.233 8 | | N-Acylsphingosine Amidohydrolase 2C3 | | Non-Lysosomal Ceramidase C3 | | ASAH2L5 |
Export aliases for ASAH2C gene to outside databasesPrevious GC identifers: GC10U900475 GC10M047523 GC10M045947 |
Summaries
for ASAH2C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ASA2C_HUMAN, P0C7U2Function: May hydrolyze the sphingolipid ceramide into sphingosine and free fatty acid (By similarity)
 summary
for ASAH2C: Ceramidases (EC 3.5.1.23) are a group of enzymes which catalyze the hydrolysis of ceramides to produce
sphingosine, which subsequently undergoes phosphorylation to generate sphingosine-1-phosphate (S1P).
Ceramide and its downstream products, sphingosine and S1P, are bioactive lipids that mediate various
cellular processes including cell growth arrest, differentiation and apoptosis. The expression of ceramides
increases in response to stressful stimuli, such as proapoptotic cytokines, cancer chemotherapeutic agents,
UV and ionizing radiation, vitamins such as retinoic acid, and serum deprivation.
Gene Wiki entry for ASAH2C
|
Genomic Views
for ASAH2C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASAH2C gene promoter:
ER-alpha STAT1 HOXA3 Evi-1 NF-AT NF-AT4 FOXC1 NF-AT2 NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASAH2C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASAH2C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.22 Ensembl cytogenetic band: 10q11.22 HGNC cytogenetic band: 10q11.22ASAH2C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M047999: view genomic region
(about GC identifiers)
Start:
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47,999,324 bp from pter |
End:
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48,055,018 bp from pter |
Size:
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55,695 bases |
Orientation:
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minus strand |
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Proteins
for ASAH2C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: ASA2C_HUMAN, P0C7U2 (See
protein sequence)Recommended Name: Putative neutral ceramidase C Size: 622 amino acids; 68749 Da
Caution: In contrast to other mammalian members of the family, ASAH2C has no predicted transmembrane domainExplore the universe of human proteins at neXtProt for ASAH2C: NX_P0C7U2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0C7U2
4/11 DME Specific Peptides for ASAH2C (P0C7U2) (see all 11)
ASAH2C Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000392320 ENSP00000399947
Human Recombinant Protein Products:
ASAH2C Antibody Products:
Assay Products for ASAH2C: |
Protein
Domains /
Families
for ASAH2C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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ASAH2C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0C7U2ProtoNet protein and cluster: P0C7U2 UniProtKB/Swiss-Prot: ASA2C_HUMAN, P0C7U2Similarity: Belongs to the neutral ceramidase family |
Function
for ASAH2C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: ASA2C_HUMAN, P0C7U2Function: May hydrolyze the sphingolipid ceramide into sphingosine and free fatty acid (By similarity)Catalytic activity: N-acylsphingosine + H(2)O = a carboxylate + sphingosineEnzyme Number (IUBMB): EC 3.5.1.231 2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0017040 | ceramidase activity |
IEA | -- |
ASAH2C for ontologies About GeneDecksing
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Pathways & Interactions
for ASAH2C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASAH2C
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ASAH2C (ENSP000003999474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006665 | sphingolipid metabolic process |
IEA | -- |
ASAH2C for ontologies About GeneDecksing
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Drugs & Compounds
for ASAH2C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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Compounds for ASAH2C available from Tocris Bioscience About this table
| Compound | Action |
CAS
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| Ceranib 1 | Ceramidase inhibitor; antiproliferative | [328076-61-5] | | Oleylethanolamide | GPR55 agonist. Also PPARalpha agonist | [111-58-0] |
10/119 HMDB Compounds for ASAH2C (see all 119) About this table
Search CenterWatch for drugs/clinical trials and news about ASAH2C / ASA2C 
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Transcripts
for ASAH2C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000420079 ENST00000426610
GeneLoc Exon Structure
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Expression
for ASAH2C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASAH2C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ASAH2C Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for ASAH2C
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ASAH2C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASAH2C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASAH2C |
Orthologs
for ASAH2C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for ASAH2C gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for ASAH2C (if available)
TreeFam Gene Tree for ASAH2C (if available) |
Paralogs
for ASAH2C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ASAH2C gene
- ASAH2B2 ASAH22
2 SIMAP similar genes for ASAH2C using alignment to 1 protein entry: ASA2C_HUMAN:ASAH2 ASAH2B
ASAH2C for paralogs About GeneDecksing
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Genomic Variants
for ASAH2C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for ASAH2C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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ASAH2C for disorders About GeneDecksing
OMIM gene information: 610987
OMIM disorders: --
3  diseases for ASAH2C: About MalaCardsalzheimer's disease tuberculosis mycobacterium tuberculosis
Export disorders for ASAH2C gene to outside databases
|
Publications
for ASAH2C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for ASAH2C gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASAH2C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease. (PubMed id 17334805)3 Avramopoulos D.... Bassett S.S. (2007)
- Identification of a novel amidase motif in neutral ceramidase. (PubMed id 16229686)1 Galadari S.... Hannun Y.A. (2006)
- Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. (PubMed id 16061940)1 Tani M.... Igarashi Y. (2005)
- Subcellular localization of human neutral ceramidase expressed in HEK293 cells. (PubMed id 15845354)1 Hwang Y.H.... Ito M. (2005)
- Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. (PubMed id 15946935)1 Osawa Y....Brenner D.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Neutral ceramidase gene: role in regulating ceramide-induced apoptosis. (PubMed id 14557071)1 Choi M.S....Mukherjee A.B. (2003)
- Molecular cloning and characterization of a human mitochondrial ceramidase. (PubMed id 10781606)1 El Bawab S....Hannun Y.A. (2000)
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External Searches for ASAH2C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ASAH2C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing ASAH2C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASAH2C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASAH2C | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ASAH2C gene:
Search GeneIP for patents involving ASAH2C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASAH2C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASAH2C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASAH2C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASAH2C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASAH2C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASAH2C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASAH2C |
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 | | | ASAH2C Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ASAH2C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ASAH2C |
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