ASAH2B Gene
protein-coding GIFtS: 40
GCID: GC10P052499
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N-acylsphingosine amidohydrolase (non-lysosomal ceramidase)...
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Aliases
for ASAH2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2B1 2 | | ASAH2-Like Protein2 3 | | ASAH2L1 2 3 5 | | ASAH2C2 5 | | BA449O16.31 | | Putative Inactive Neutral Ceramidase B2 | | Putative Inactive N-Acylsphingosine Amidohydrolase 2B2 3 | | EC 3.5.1.238 | | Putative Inactive Non-Lysosomal Ceramidase B2 3 | | |
Export aliases for ASAH2B gene to outside databasesPrevious GC identifers: GC00U914492 GC10U900594 GC10P052169 GC10P046471 |
Summaries
for ASAH2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for ASAH2B
|
Genomic Views
for ASAH2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ASAH2B gene promoter:
Pbx1a Tal-1 AML1a POU6F1 (c2) Tal-1beta E47 Max Sox9 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ASAH2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASAH2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC cytogenetic band: 10q11.23ASAH2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P052499: view genomic region
(about GC identifiers)
Start:
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52,499,078 bp from pter |
End:
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52,576,255 bp from pter |
Size:
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77,178 bases |
Orientation:
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plus strand |
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Proteins
for ASAH2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ASA2B_HUMAN, P0C7U1 (See
protein sequence)Recommended Name: Putative inactive neutral ceramidase B Size: 165 amino acids; 19025 Da
Miscellaneous: ASAH2B/ASAH2L is a partial paralog of ASAH2, resulting from a partial duplication of ASAH2 on chromosome10. It has a polymorphic start codon with a single nucleotide change of the original ASAH2 sequence plus otherputative translation start site that might lead to several potential ORFs
Caution: In contrast to other members of the family, ASAH2B has no predicted transmembrane domain, and lacks the activesite, suggesting that it may be catalytically inactiveExplore the universe of human proteins at neXtProt for ASAH2B: NX_P0C7U1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0C7U1
2 DME Specific Peptides for ASAH2B (P0C7U1)
ASAH2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001072984.1
ENSEMBL proteins: ENSP00000363119 ENSP00000363118 ENSP00000185907
Human Recombinant Protein Products:
ASAH2B Antibody Products:
Assay Products for ASAH2B: |
Protein
Domains /
Families
for ASAH2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ASAH2B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0C7U1ProtoNet protein and cluster: P0C7U1 UniProtKB/Swiss-Prot: ASA2B_HUMAN, P0C7U1Similarity: Belongs to the neutral ceramidase family |
Function
for ASAH2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.5.1.232
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASAH2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASAH2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ASAH2B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ASAH2B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASAH2B |
|
Pathways & Interactions
for ASAH2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | sphingosine and sphingosine-1-phosphate metabolism | | | 2 | ceramide degradation | |
2  BioSystems Pathways for ASAH2B
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ASAH2B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ASAH2B (ENSP000001859074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for ASAH2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Compounds for ASAH2B available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Ceranib 1 | Ceramidase inhibitor; antiproliferative | [328076-61-5] | | Oleylethanolamide | GPR55 agonist. Also PPARalpha agonist | [111-58-0] |
Search CenterWatch for drugs/clinical trials and news about ASAH2B / ASA2B
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Transcripts
for ASAH2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ASAH2B gene: NM_001079516.2 Unigene Cluster for ASAH2B: N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B Hs.710005 [show with all ESTs]Unigene Representative Sequence: AK2943694 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374007 ENST00000374006(uc001jjg.3) ENST00000483649 ENST00000185907(uc010qhm.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASAH2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASAH2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ASAH2B (NM_001079516) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ASAH2B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ASAH2B |
Additional cDNA sequence: AK294369.1 4 DOTS entries: DT.101960569 DT.40299275 DT.121268974 DT.95368087
GeneLoc Exon Structure
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Expression
for ASAH2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ASAH2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ASAH2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ASAH2B
SOURCE GeneReport for Unigene cluster: Hs.710005
UniProtKB/Swiss-Prot: ASA2B_HUMAN, P0C7U1Tissue specificity: Ubiquitous. Expression is reduced with increasing age and in late-onset Alzheimer disease (LOAD)patients. This reduction is even more pronounced in patients with an affected mother
SABiosciences Custom PCR Arrays for ASAH2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASAH2B
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ASAH2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASAH2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASAH2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASAH2B |
Orthologs
for ASAH2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for ASAH2B gene from 6/19 species (see all 19) About this table
Species with no ortholog for ASAH2B
ENSEMBL Gene Tree for ASAH2B (if available)
TreeFam Gene Tree for ASAH2B (if available) |
Paralogs
for ASAH2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ASAH2B gene
- ASAH2C2 ASAH22
2 SIMAP similar genes for ASAH2B using alignment to 2 protein entries: ASA2B_HUMAN (see all proteins):ASAH2 ASAH2C
ASAH2B for paralogs About GeneDecksing
|
Genomic Variants
for ASAH2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ASAH2B (52499078 - 52576255 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ASAH2B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASAH2B |
|
Disorders
/ Diseases
for ASAH2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ASAH2B for disorders About GeneDecksing
OMIM gene information: 610987
OMIM disorders: --
3  diseases for ASAH2B: About MalaCardsalzheimer's disease tuberculosis mycobacterium tuberculosis
Export disorders for ASAH2B gene to outside databases
|
Publications
for ASAH2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ASAH2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ASAH2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease. (PubMed id 17334805)1, 2, 3 Avramopoulos D.... Bassett S.S. (2007)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
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External Searches for ASAH2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ASAH2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ASAH2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ASAH2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ASAH2B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ASAH2B gene:
Search GeneIP for patents involving ASAH2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ASAH2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ASAH2B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ASAH2B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ASAH2B | | | OriGene Protein Over-expression Lysate for ASAH2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ASAH2B | | OriGene 3'-UTR Clone for ASAH2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ASAH2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ASAH2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ASAH2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ASAH2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ASAH2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ASAH2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ASAH2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ASAH2B |
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 | | | ASAH2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ASAH2B |
|  |  |  | | | | Search ThermoFisher Antibodies for ASAH2B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ASAH2B |
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