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Aliases for AS3MT Gene

Aliases for AS3MT Gene

  • Arsenite Methyltransferase 2 3
  • CYT19 3 4 6
  • S-Adenosyl-L-Methionine:Arsenic(III) Methyltransferase 3 4
  • Arsenic (+3 Oxidation State) Methyltransferase 2 3
  • Methylarsonite Methyltransferase 3 4
  • S-Adenosylmethionine:Arsenic (III) Methyltransferase 3
  • Methyltransferase Cyt19 3
  • EC 2.1.1.137 4

External Ids for AS3MT Gene

Previous GeneCards Identifiers for AS3MT Gene

  • GC10P104294
  • GC10P104606
  • GC10P104621
  • GC10P104603
  • GC10P104623
  • GC10P104624
  • GC10P098263
  • GC10P104629

Summaries for AS3MT Gene

Entrez Gene Summary for AS3MT Gene

  • AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]

GeneCards Summary for AS3MT Gene

AS3MT (Arsenite Methyltransferase) is a Protein Coding gene. Among its related pathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and arsenate detoxification I (glutaredoxin). GO annotations related to this gene include arsenite methyltransferase activity and methylarsonite methyltransferase activity.

UniProtKB/Swiss-Prot for AS3MT Gene

  • Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).

Gene Wiki entry for AS3MT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AS3MT Gene

Genomics for AS3MT Gene

Regulatory Elements for AS3MT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for AS3MT Gene

Start:
102,869,453 bp from pter
End:
102,901,899 bp from pter
Size:
32,447 bases
Orientation:
Plus strand

Genomic View for AS3MT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AS3MT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AS3MT Gene

Proteins for AS3MT Gene

  • Protein details for AS3MT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBK9-AS3MT_HUMAN
    Recommended name:
    Arsenite methyltransferase
    Protein Accession:
    Q9HBK9
    Secondary Accessions:
    • A6NP79
    • Q0VDK3
    • Q0VDK4
    • Q5PZ02

    Protein attributes for AS3MT Gene

    Size:
    375 amino acids
    Molecular mass:
    41748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG09731.1; Type=Frameshift; Positions=333; Evidence={ECO:0000305};

    Alternative splice isoforms for AS3MT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AS3MT Gene

Proteomics data for AS3MT Gene at MOPED

Post-translational modifications for AS3MT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AS3MT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AS3MT Gene

Domains for AS3MT Gene

Protein Domains for AS3MT Gene

Suggested Antigen Peptide Sequences for AS3MT Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBK9

UniProtKB/Swiss-Prot:

AS3MT_HUMAN :
  • Q9HBK9
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with AS3MT: view

No data available for Gene Families for AS3MT Gene

Function for AS3MT Gene

Molecular function for AS3MT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=4.6 uM for sodium arsenite {ECO:0000269 PubMed:16407288}; KM=11.8 uM for AdoMet {ECO:0000269 PubMed:16407288};
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).

Enzyme Numbers (IUBMB) for AS3MT Gene

Gene Ontology (GO) - Molecular Function for AS3MT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity --
GO:0008168 methyltransferase activity --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IBA --
GO:0030791 arsenite methyltransferase activity ISS --
GO:0030792 methylarsonite methyltransferase activity ISS --
genes like me logo Genes that share ontologies with AS3MT: view

Phenotypes for AS3MT Gene

genes like me logo Genes that share phenotypes with AS3MT: view

Animal Models for AS3MT Gene

MGI Knock Outs for AS3MT:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for AS3MT Gene

Localization for AS3MT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AS3MT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AS3MT Gene COMPARTMENTS Subcellular localization image for AS3MT gene
Compartment Confidence
cytosol 4
extracellular 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for AS3MT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with AS3MT: view

Pathways for AS3MT Gene

genes like me logo Genes that share pathways with AS3MT: view

Pathways by source for AS3MT Gene

1 Qiagen pathway for AS3MT Gene
1 BioSystems pathway for AS3MT Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for AS3MT Gene

Gene Ontology (GO) - Biological Process for AS3MT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0008152 metabolic process --
GO:0009404 toxin metabolic process ISS --
GO:0018872 arsonoacetate metabolic process ISS --
GO:0032259 methylation IBA --
genes like me logo Genes that share ontologies with AS3MT: view

Compounds for AS3MT Gene

(6) HMDB Compounds for AS3MT Gene

Compound Synonyms Cas Number PubMed IDs
Arsenic
  • As
7440-38-2
Arsenite
  • AArsenite (AsO33-)
15502-74-6
Dimethylarsinate
  • dimethylarsinate
15132-04-4
L-Methionine
  • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
63-68-3
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0

(4) Novoseek inferred chemical compound relationships for AS3MT Gene

Compound -log(P) Hits PubMed IDs
arsenicals 87.8 4
arsenite 81.3 11
arsenate 80.6 1
s-adenosylmethionine 64.2 2
genes like me logo Genes that share compounds with AS3MT: view

Transcripts for AS3MT Gene

mRNA/cDNA for AS3MT Gene

Unigene Clusters for AS3MT Gene

Arsenic (+3 oxidation state) methyltransferase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for AS3MT

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for AS3MT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AS3MT Gene

No ASD Table

Relevant External Links for AS3MT Gene

GeneLoc Exon Structure for
AS3MT
ECgene alternative splicing isoforms for
AS3MT

Expression for AS3MT Gene

mRNA expression in normal human tissues for AS3MT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AS3MT Gene

This gene is overexpressed in Adrenal Gland (30.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for AS3MT Gene

SOURCE GeneReport for Unigene cluster for AS3MT Gene Hs.720370

genes like me logo Genes that share expressions with AS3MT: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AS3MT Gene

Orthologs for AS3MT Gene

This gene was present in the common ancestor of chordates.

Orthologs for AS3MT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AS3MT 35
  • 99.29 (n)
  • 98.67 (a)
AS3MT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 71 (a)
OneToMany
AS3MT 35
  • 87.9 (n)
  • 84.14 (a)
AS3MT 36
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia AS3MT 35
  • 88.05 (n)
  • 86.48 (a)
mouse
(Mus musculus)
Mammalia As3mt 35
  • 81.24 (n)
  • 76.8 (a)
As3mt 16
As3mt 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AS3MT 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia As3mt 35
  • 80.49 (n)
  • 77.24 (a)
chicken
(Gallus gallus)
Aves AS3MT 35
  • 63.28 (n)
  • 62.09 (a)
AS3MT 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AS3MT 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia as3mt 35
  • 64.72 (n)
  • 61.84 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9677 35
zebrafish
(Danio rerio)
Actinopterygii as3mt 35
  • 60.98 (n)
  • 53.39 (a)
as3mt 36
  • 52 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12976 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
CSA.5398 36
  • 51 (a)
OneToMany
Species with no ortholog for AS3MT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AS3MT Gene

ENSEMBL:
Gene Tree for AS3MT (if available)
TreeFam:
Gene Tree for AS3MT (if available)

Paralogs for AS3MT Gene

No data available for Paralogs for AS3MT Gene

Variants for AS3MT Gene

Sequence variations from dbSNP and Humsavar for AS3MT Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_027392 -
VAR_027393 -
VAR_027394 -

Structural Variations from Database of Genomic Variants (DGV) for AS3MT Gene

Variant ID Type Subtype PubMed ID
esv2740239 CNV Deletion 23290073
esv2489056 CNV Deletion 19546169
esv2740251 CNV Deletion 23290073
esv1651901 CNV Deletion 17803354

Relevant External Links for AS3MT Gene

HapMap Linkage Disequilibrium report
AS3MT
Human Gene Mutation Database (HGMD)
AS3MT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AS3MT Gene

Disorders for AS3MT Gene

Relevant External Links for AS3MT

Genetic Association Database (GAD)
AS3MT
Human Genome Epidemiology (HuGE) Navigator
AS3MT
genes like me logo Genes that share disorders with AS3MT: view

No data available for UniProtKB/Swiss-Prot for AS3MT Gene

Publications for AS3MT Gene

  1. Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina. (PMID: 17450230) SchlAowicke EngstrAPm K. … Vahter M. (Environ. Health Perspect. 2007) 3 23 48
  2. Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method. (PMID: 17889916) Fujihara J. … Takeshita H. (Toxicol. Appl. Pharmacol. 2007) 3 23 48
  3. Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione S-transferase omega genes. (PMID: 18414634) De Chaudhuri S. … Giri A.K. (Environ. Health Perspect. 2008) 3 23 48
  4. Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies. (PMID: 16407288) Wood T.C. … Weinshilboum R.M. (J. Biol. Chem. 2006) 3 4 23
  5. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PMID: 18682255) SchlAowicke EngstrAPm K. … Broberg K. (Mutat. Res. 2009) 3 23 48

Products for AS3MT Gene

Sources for AS3MT Gene

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