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Aliases for AS3MT Gene

Aliases for AS3MT Gene

  • Arsenite Methyltransferase 2 3 5
  • S-Adenosyl-L-Methionine:Arsenic(III) Methyltransferase 3 4
  • Arsenic (+3 Oxidation State) Methyltransferase 2 3
  • Methylarsonite Methyltransferase 3 4
  • CYT19 3 4
  • S-Adenosylmethionine:Arsenic (III) Methyltransferase 3
  • Methyltransferase Cyt19 3
  • EC 2.1.1.137 4

External Ids for AS3MT Gene

Previous GeneCards Identifiers for AS3MT Gene

  • GC10P104294
  • GC10P104606
  • GC10P104621
  • GC10P104603
  • GC10P104623
  • GC10P104624
  • GC10P098263
  • GC10P104629

Summaries for AS3MT Gene

Entrez Gene Summary for AS3MT Gene

  • AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]

GeneCards Summary for AS3MT Gene

AS3MT (Arsenite Methyltransferase) is a Protein Coding gene. Among its related pathways are Phase II conjugation and Metabolism. GO annotations related to this gene include methyltransferase activity and protein-L-isoaspartate (D-aspartate) O-methyltransferase activity.

UniProtKB/Swiss-Prot for AS3MT Gene

  • Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).

Gene Wiki entry for AS3MT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AS3MT Gene

Genomics for AS3MT Gene

Regulatory Elements for AS3MT Gene

Enhancers for AS3MT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around AS3MT on UCSC Golden Path with GeneCards custom track

Promoters for AS3MT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for AS3MT Gene

Chromosome:
10
Start:
102,869,453 bp from pter
End:
102,901,899 bp from pter
Size:
32,447 bases
Orientation:
Plus strand

Genomic View for AS3MT Gene

Genes around AS3MT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AS3MT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AS3MT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AS3MT Gene

Proteins for AS3MT Gene

  • Protein details for AS3MT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBK9-AS3MT_HUMAN
    Recommended name:
    Arsenite methyltransferase
    Protein Accession:
    Q9HBK9
    Secondary Accessions:
    • A6NP79
    • Q0VDK3
    • Q0VDK4
    • Q5PZ02

    Protein attributes for AS3MT Gene

    Size:
    375 amino acids
    Molecular mass:
    41748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG09731.1; Type=Frameshift; Positions=333; Evidence={ECO:0000305};

    Alternative splice isoforms for AS3MT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AS3MT Gene

Post-translational modifications for AS3MT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AS3MT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AS3MT Gene

Domains & Families for AS3MT Gene

Protein Domains for AS3MT Gene

Suggested Antigen Peptide Sequences for AS3MT Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBK9

UniProtKB/Swiss-Prot:

AS3MT_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with AS3MT: view

No data available for Gene Families for AS3MT Gene

Function for AS3MT Gene

Molecular function for AS3MT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.6 uM for sodium arsenite {ECO:0000269 PubMed:16407288}; KM=11.8 uM for AdoMet {ECO:0000269 PubMed:16407288};
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).

Enzyme Numbers (IUBMB) for AS3MT Gene

Gene Ontology (GO) - Molecular Function for AS3MT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IBA --
GO:0030791 arsenite methyltransferase activity TAS --
GO:0030792 methylarsonite methyltransferase activity ISS --
genes like me logo Genes that share ontologies with AS3MT: view
genes like me logo Genes that share phenotypes with AS3MT: view

Animal Models for AS3MT Gene

MGI Knock Outs for AS3MT:

Animal Model Products

  • Taconic Biosciences Mouse Models for AS3MT

CRISPR Products

miRNA for AS3MT Gene

miRTarBase miRNAs that target AS3MT

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AS3MT Gene

Localization for AS3MT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AS3MT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AS3MT Gene COMPARTMENTS Subcellular localization image for AS3MT gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for AS3MT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with AS3MT: view

Pathways & Interactions for AS3MT Gene

genes like me logo Genes that share pathways with AS3MT: view

Pathways by source for AS3MT Gene

1 BioSystems pathway for AS3MT Gene
1 Qiagen pathway for AS3MT Gene

Interacting Proteins for AS3MT Gene

Selected Interacting proteins: Q9HBK9-AS3MT_HUMAN for AS3MT Gene via IID

Gene Ontology (GO) - Biological Process for AS3MT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009404 toxin metabolic process ISS --
GO:0018872 arsonoacetate metabolic process ISS --
GO:0032259 methylation TAS --
genes like me logo Genes that share ontologies with AS3MT: view

No data available for SIGNOR curated interactions for AS3MT Gene

Drugs & Compounds for AS3MT Gene

(3) Drugs for AS3MT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
L-Methionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0

(7) Additional Compounds for AS3MT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
Arsenic
  • Arsen
  • Arsen [german,polish]
  • Arsenic black
  • Arsenic elemental
  • Arsenowodor [polish]
7440-38-2
Dimethylarsinate
  • Ansar
  • Arsan
  • Bolate
  • Bolls
  • Cacodylate
15132-04-4
Methylarsonate
  • Dsma (jmaf)
  • Kyselina methylarsonova
  • Kyselina methylarsonova [czech]
  • MAA
  • MeAsO(OH)2
124-58-3
Methylarsonite
  • MeAs(OH)2
  • Methanearsonous acid
  • Methyl Arsonous acid
  • Methylarsonous acid
  • Mma(III)
25400-23-1
genes like me logo Genes that share compounds with AS3MT: view

Transcripts for AS3MT Gene

mRNA/cDNA for AS3MT Gene

Unigene Clusters for AS3MT Gene

Arsenic (+3 oxidation state) methyltransferase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AS3MT Gene

No ASD Table

Relevant External Links for AS3MT Gene

GeneLoc Exon Structure for
AS3MT
ECgene alternative splicing isoforms for
AS3MT

Expression for AS3MT Gene

mRNA expression in normal human tissues for AS3MT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AS3MT Gene

This gene is overexpressed in Adrenal Gland (x30.7).

Protein differential expression in normal tissues from HIPED for AS3MT Gene

This gene is overexpressed in Adrenal (40.6), Cerebrospinal fluid (7.3), Fetal testis (6.8), and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AS3MT Gene



NURSA nuclear receptor signaling pathways regulating expression of AS3MT Gene:

AS3MT

SOURCE GeneReport for Unigene cluster for AS3MT Gene:

Hs.720370
genes like me logo Genes that share expression patterns with AS3MT: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for AS3MT Gene

Orthologs for AS3MT Gene

This gene was present in the common ancestor of chordates.

Orthologs for AS3MT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AS3MT 34
  • 87.9 (n)
  • 84.14 (a)
-- 35
  • 71 (a)
OneToMany
AS3MT 35
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia AS3MT 34
  • 88.05 (n)
  • 86.48 (a)
mouse
(Mus musculus)
Mammalia As3mt 34
  • 81.24 (n)
  • 76.8 (a)
As3mt 16
As3mt 35
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AS3MT 34
  • 99.29 (n)
  • 98.67 (a)
AS3MT 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia As3mt 34
  • 80.49 (n)
  • 77.24 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia AS3MT 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves AS3MT 34
  • 63.28 (n)
  • 62.09 (a)
AS3MT 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AS3MT 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia as3mt 34
  • 64.72 (n)
  • 61.84 (a)
zebrafish
(Danio rerio)
Actinopterygii as3mt 34
  • 60.98 (n)
  • 53.39 (a)
as3mt 35
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9677 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
CSA.5398 35
  • 51 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12976 34
Species where no ortholog for AS3MT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AS3MT Gene

ENSEMBL:
Gene Tree for AS3MT (if available)
TreeFam:
Gene Tree for AS3MT (if available)

Paralogs for AS3MT Gene

No data available for Paralogs for AS3MT Gene

Variants for AS3MT Gene

Sequence variations from dbSNP and Humsavar for AS3MT Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_027392 -
VAR_027393 -
VAR_027394 -

Structural Variations from Database of Genomic Variants (DGV) for AS3MT Gene

Variant ID Type Subtype PubMed ID
esv1651901 CNV deletion 17803354
esv2489056 CNV deletion 19546169
esv2740239 CNV deletion 23290073
esv2740251 CNV deletion 23290073
esv3546767 CNV deletion 23714750
esv3624404 CNV loss 21293372
nsv1069070 CNV deletion 25765185
nsv1147211 CNV deletion 26484159
nsv948172 CNV duplication 23825009

Variation tolerance for AS3MT Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AS3MT Gene

Human Gene Mutation Database (HGMD)
AS3MT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
AS3MT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AS3MT Gene

Disorders for AS3MT Gene

Relevant External Links for AS3MT

Genetic Association Database (GAD)
AS3MT
Human Genome Epidemiology (HuGE) Navigator
AS3MT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AS3MT

No disorders were found for AS3MT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AS3MT Gene

Publications for AS3MT Gene

  1. Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic. (PMID: 19896490) EngstrAPm K.S. … Broberg K. (Mutat. Res. 2010) 3 22 46 65
  2. Global analysis of genetic variation in human arsenic (+3 oxidation state) methyltransferase (AS3MT). (PMID: 19932709) Fujihara J. … Takeshita H. (Toxicol. Appl. Pharmacol. 2010) 3 22 46 65
  3. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PMID: 18682255) SchlAowicke EngstrAPm K. … Broberg K. (Mutat. Res. 2009) 3 22 46 65
  4. Ethnic differences in five intronic polymorphisms associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene. (PMID: 18976679) Fujihara J. … Takeshita H. (Toxicol. Appl. Pharmacol. 2009) 3 22 46 65
  5. Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions. (PMID: 19538983) Valenzuela O.L. … Del Razo L.M. (Toxicol. Appl. Pharmacol. 2009) 3 22 46 65

Products for AS3MT Gene

Sources for AS3MT Gene

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