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AS3MT Gene

protein-coding   GIFtS: 51
GCID: GC10P104629

Arsenic (+3 Oxidation State) Methyltransferase

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arsenic (+3 Oxidation State) Methyltransferase1 2     Arsenite Methyltransferase2
CYT192 3 5     Methyltransferase Cyt192
Methylarsonite Methyltransferase2 3     S-Adenosylmethionine:Arsenic (III) Methyltransferase2
S-Adenosyl-L-Methionine:Arsenic(III) Methyltransferase2 3     EC 2.1.1.1373

External Ids:    HGNC: 174521   Entrez Gene: 574122   Ensembl: ENSG000002144357   OMIM: 6118065   UniProtKB: Q9HBK93   

Export aliases for AS3MT gene to outside databases

Previous GC identifers: GC10P104294 GC10P104606 GC10P104621 GC10P104603 GC10P104623 GC10P104624 GC10P098263


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for AS3MT Gene:
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and
may play a role in arsenic metabolism (Lin et al., 2002 (PubMed 11790780)).(supplied by OMIM, Mar 2008)

GeneCards Summary for AS3MT Gene:
AS3MT (arsenic (+3 oxidation state) methyltransferase) is a protein-coding gene. Diseases associated with AS3MT include alzheimer's disease, and schizophrenia. GO annotations related to this gene include methylarsonite methyltransferase activity and arsenite methyltransferase activity.

UniProtKB/Swiss-Prot: AS3MT_HUMAN, Q9HBK9
Function: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and
dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by
methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted
into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)

Gene Wiki entry for AS3MT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the AS3MT gene promoter:
         E2F-4   E2F-3a   E2F-5   C/EBPbeta   FOXO3   E2F-2   C/EBPalpha   E2F   E2F-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidAS3MT promoter sequence
   Search Chromatin IP Primers for AS3MT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat AS3MT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.33

AS3MT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
AS3MT gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104629:  view genomic region     (about GC identifiers)

Start:
104,629,210 bp from pter      End:
104,661,656 bp from pter
Size:
32,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AS3MT_HUMAN, Q9HBK9 (See protein sequence)
Recommended Name: Arsenite methyltransferase  
Size: 375 amino acids; 41748 Da
Sequence caution: Sequence=AAG09731.1; Type=Frameshift; Positions=333;
Secondary accessions: A6NP79 Q0VDK3 Q0VDK4 Q5PZ02
Alternative splicing: 2 isoforms:  Q9HBK9-1   Q9HBK9-2   (Devoid of methyltransferase activity)

Explore the universe of human proteins at neXtProt for AS3MT: NX_Q9HBK9

Explore proteomics data for AS3MT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See AS3MT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065733.2  
    ENSEMBL proteins: 
     ENSP00000358896  

    AS3MT Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR025714 Methyltranfer_dom
     IPR026669 Arsenite_MeTrfase

    Graphical View of Domain Structure for InterPro Entry Q9HBK9

    ProtoNet protein and cluster: Q9HBK9

    1 Blocks protein domain: IPB013216 Methyltransferase type 11

    UniProtKB/Swiss-Prot: AS3MT_HUMAN, Q9HBK9
    Similarity: Belongs to the methyltransferase superfamily


    AS3MT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AS3MT_HUMAN, Q9HBK9
    Function: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and
    dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by
    methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted
    into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate
    Catalytic activity: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate
    Biophysicochemical properties: Kinetic parameters: KM=4.6 uM for sodium arsenite; KM=11.8 uM for AdoMet;

         Enzyme Number (IUBMB): EC 2.1.1.1371

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004719protein-L-isoaspartate (D-aspartate) O-methyltransferase activity ----
    GO:0008168methyltransferase activity ----
    GO:0030791arsenite methyltransferase activity ISS--
    GO:0030792methylarsonite methyltransferase activity ISS--
         
    AS3MT for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for As3mt):
     homeostasis/metabolism  liver/biliary system 

    AS3MT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out As3mttm1Djth for AS3MT

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for AS3MT
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for AS3MT

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    7 qRT-PCR Assays for microRNAs that regulate AS3MT:
    hsa-miR-708 hsa-miR-182 hsa-miR-593* hsa-miR-28-5p hsa-miR-1252 hsa-miR-3139 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidAS3MT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat AS3MT

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat AS3MT

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for AS3MT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AS3MT_HUMAN, Q9HBK9: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    mitochondrion2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol ISS--

    AS3MT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for AS3MT About    
    See pathways by source

    SuperPathContained pathways About
    1arsenate detoxification I (glutaredoxin)
    arsenate detoxification I (glutaredoxin)

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for AS3MT
        Aldosterone Signaling in Epithelial Cells

    1 BioSystems Pathway for AS3MT
        arsenate detoxification I (glutaredoxin)



        Pathway & Disease-focused RT2 Profiler PCR Array including AS3MT: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for AS3MT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for AS3MT (ENSP000003588964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSTO1ENSP000003587274STRING: ENSP00000358727
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process ----
    GO:0008152metabolic process ----
    GO:0009404toxin metabolic process ISS--
    GO:0018872arsonoacetate metabolic process ISS--

    AS3MT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for AS3MT

    6 HMDB Compounds for AS3MT    About this table
    CompoundSynonyms CAS #PubMed Ids
    ArsenicAs (see all 9)7440-38-2--
    ArseniteAArsenite (AsO33-) (see all 16)15502-74-6--
    Dimethylarsinatedimethylarsinate (see all 17)15132-04-4--
    L-Methionine(2S)-2-amino-4-(methylsulfanyl)butanoic acid (see all 54)63-68-3--
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    4 Novoseek inferred chemical compound relationships for AS3MT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arsenicals 87.8 4 19538983 (1), 19691357 (1), 15276411 (1), 15526190 (1)
    arsenite 81.3 19 11684318 (2), 19411561 (2), 16102566 (1), 19932709 (1) (see all 9)
    arsenate 80.6 1 10328340 (1)
    s-adenosylmethionine 64.2 2 19538983 (1), 15526190 (1)



    AS3MT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for AS3MT gene: 
    NM_020682.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369880(uc001kwj.3 uc009xxh.3 uc001kwk.3)

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate AS3MT:
    hsa-miR-708 hsa-miR-182 hsa-miR-593* hsa-miR-28-5p hsa-miR-1252 hsa-miR-3139 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidAS3MT 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat AS3MT

    Selected AceView cDNA sequences (see all 261):

    BU189046 CA952522 BU074588 CA777536 AI868325 W04252 AA234980 AI628634 
    AI652047 AW161513 CA444341 BX279728 BF196047 BQ028789 AK098071 BQ186811 
    BF056533 AI216455 AW301647 AV650273 AA976545 AI675080 AI126419 AI580507 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    AS3MT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGGTAGGA
    AS3MT Expression
    About this image


    AS3MT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Kidney (Urinary System)
    AS3MT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    AS3MT Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including AS3MT: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for AS3MT gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia As3mt1 , 5 arsenic (+3 oxidation state) methyltransferase1, 5 81.24(n)1
    76.8(a)1
      19 (38.97 cM)5
    573441  NM_020577.21  NP_065602.21 
     467074435 
    chicken
    (Gallus gallus)
    Aves AS3MT1 arsenic (+3 oxidation state) methyltransferase 63.28(n)
    62.09(a)
      423870  XM_421735.4  XP_421735.3 
    lizard
    (Anolis carolinensis)
    Reptilia AS3MT6
    arsenic (+3 oxidation state) methyltransferase
    63(a)
    1 ↔ 1
    3(40291565-40326315)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia as3mt1 arsenic (+3 oxidation state) methyltransferase 64.72(n)
    61.84(a)
      100216291  NM_001142242.1  NP_001135714.1 
    zebrafish
    (Danio rerio)
    Actinopterygii as3mt1 arsenic (+3 oxidation state) methyltransferase 60.98(n)
    53.39(a)
      664699  NM_001039839.1  NP_001034928.1 


    ENSEMBL Gene Tree for AS3MT (if available)
    TreeFam Gene Tree for AS3MT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for AS3MT (see all 17)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs667919241,2
    C--104629366(-) GCGCC-/CAGGGCGCGCACTCACT
    GTCTCCTCGGCCTGCGACT
    CAGGG
    1 -- cds11Minor allele frequency- CAGGGCGCGCACTCACTGTCTCCTCGGCCTGCGACT:0.00NA 2
    rs38326851,2
    C--104629793(-) AAGAG-/GAGCTGTG 1 -- cds10--------
    rs1397923281,2
    C--104631485(+) GTCTC-/AAAC  
      AAAACA
    AAACA
    1 -- int10--------
    rs178797811,2
    C--104633053(+) TTATTTTT/-GAGAT 1 -- cds11Minor allele frequency- -:0.00NA 2
    rs340062631,2
    C--104639667(+) TATAT-/A/AT  
            
    TTATT
    1 -- int11NA 2
    rs1473552451,2
    C--104646089(+) TTTTT-/TGAGAG 1 -- int10--------
    rs3740240941,2
    C--104648628(+) ATATA-/ATAT  
     ATATATA
    TATAT
    1 -- int10--------
    rs346436071,2
    C--104652815(+) AAAAAA/-CTGTA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs352328871,2,4
    ----see VAR_0273922 mis40--------
    rs345564381,2,4
    ----see VAR_0273942 mis40--------

    HapMap Linkage Disequilibrium report for AS3MT (104629210 - 104661656 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for AS3MT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740239CNV Deletion23290073
    esv1651901CNV Deletion17803354
    esv2740251CNV Deletion23290073
    esv2489056CNV Deletion19546169

    Human Gene Mutation Database (HGMD): AS3MT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing AS3MT
    DNA2.0 Custom Variant and Variant Library Synthesis for AS3MT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611806    OMIM disorders: --

    4 diseases for AS3MT:    
    About MalaCards
    alzheimer's disease    schizophrenia    prostate cancer    prostatitis


    AS3MT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): AS3MT
    Human Genome Epidemiology (HuGE) Navigator: AS3MT (23 documents)

    Export disorders for AS3MT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for AS3MT gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with AS3MT)
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    1. High arsenic metabolic efficiency in AS3MT287Thr allele carriers. (PubMed id 18334919)1, 2, 4 Hernandez A.... Marcos R. (Pharmacogenet. Genomics 2008)
    2. Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions. (PubMed id 19538983)1, 4, 9 Valenzuela O.L....Del Razo L.M. (Toxicol. Appl. Pharmacol. 2009)
    3. Global analysis of genetic variation in human arsenic (+3 oxidation state) methyltransferase (AS3MT). (PubMed id 19932709)1, 4, 9 Fujihara J....Takeshita H. (Toxicol. Appl. Pharmacol. 2010)
    4. Ethnic differences in five intronic polymorphisms associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene. (PubMed id 18976679)1, 4, 9 Fujihara J....Takeshita H. (Toxicol. Appl. Pharmacol. 2009)
    5. Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies. (PubMed id 16407288)1, 2, 9 Wood T.C....Weinshilboum R.M. (J. Biol. Chem. 2006)
    6. Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method. (PubMed id 17889916)1, 4, 9 Fujihara J....Takeshita H. (Toxicol. Appl. Pharmacol. 2007)
    7. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PubMed id 18682255)1, 4, 9 SchlAowicke EngstrAPm K....Broberg K. (Mutat. Res. 2009)
    8. Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione S-transferase omega genes. (PubMed id 18414634)1, 4, 9 De Chaudhuri S....Giri A.K. (Environ. Health Perspect. 2008)
    9. Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina. (PubMed id 17450230)1, 4, 9 SchlAowicke EngstrAPm K....Vahter M. (Environ. Health Perspect. 2007)
    10. Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic. (PubMed id 19896490)1, 4, 9 EngstrAPm K.S....Broberg K. (Mutat. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57412 HGNC: 17452 AceView: AS3MTandC10orf32 Ensembl:ENSG00000214435 euGenes: HUgn57412
    ECgene: AS3MT H-InvDB: AS3MT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for AS3MT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for AS3MT gene:
    Search GeneIP for patents involving AS3MT

    GeneCards and IP:
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