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Aliases for ARV1 Gene

Aliases for ARV1 Gene

  • ARV1 Homolog, Fatty Acid Homeostasis Modulator 2 3
  • HARV1 3 4
  • ARV1 Homolog, Fatty Acid Homeostatsis Modulator 3
  • ARV1 Fatty Acid Homeostatsis Modulator 3
  • ARV1 Homolog (S. Cerevisiae) 2
  • ARV1 Homolog (Yeast) 2

External Ids for ARV1 Gene

Previous GeneCards Identifiers for ARV1 Gene

  • GC01P229604
  • GC01P226843
  • GC01P227587
  • GC01P228149
  • GC01P227421
  • GC01P229181
  • GC01P231114
  • GC01P201599

Summaries for ARV1 Gene

GeneCards Summary for ARV1 Gene

ARV1 (ARV1 Homolog, Fatty Acid Homeostasis Modulator) is a Protein Coding gene. Among its related pathways are Metabolism and Terpenoid backbone biosynthesis.

UniProtKB/Swiss-Prot for ARV1 Gene

  • May act as a mediator of sterol homeostasis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARV1 Gene

Genomics for ARV1 Gene

Regulatory Elements for ARV1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARV1 Gene

Chromosome:
1
Start:
230,978,981 bp from pter
End:
231,000,733 bp from pter
Size:
21,753 bases
Orientation:
Plus strand

Genomic View for ARV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARV1 Gene

Proteins for ARV1 Gene

  • Protein details for ARV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2C2-ARV1_HUMAN
    Recommended name:
    Protein ARV1
    Protein Accession:
    Q9H2C2
    Secondary Accessions:
    • A8KAI4
    • Q5VSN7
    • Q5VSN8
    • Q5VSN9
    • Q5VSP0
    • Q5VSP2
    • Q9H2H2
    • Q9H5V6
    • Q9UFF5

    Protein attributes for ARV1 Gene

    Size:
    271 amino acids
    Molecular mass:
    31052 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • When transfected in S.cerevisiae, it can complement the absence of yeast of ARV1 protein, suggesting a conserved role in sphingolipid metabolism
    SequenceCaution:
    • Sequence=BAB15513.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAH73699.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73700.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH73701.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15334.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15335.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ARV1 Gene

Proteomics data for ARV1 Gene at MOPED

Post-translational modifications for ARV1 Gene

  • Ubiquitination at Lys 42 and Lys 136
  • Modification sites at PhosphoSitePlus

Other Protein References for ARV1 Gene

No data available for DME Specific Peptides for ARV1 Gene

Domains & Families for ARV1 Gene

Protein Domains for ARV1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARV1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2C2

UniProtKB/Swiss-Prot:

ARV1_HUMAN :
  • Belongs to the ARV1 family.
Family:
  • Belongs to the ARV1 family.
genes like me logo Genes that share domains with ARV1: view

No data available for Gene Families for ARV1 Gene

Function for ARV1 Gene

Molecular function for ARV1 Gene

UniProtKB/Swiss-Prot Function:
May act as a mediator of sterol homeostasis.

Phenotypes for ARV1 Gene

GenomeRNAi human phenotypes for ARV1:
genes like me logo Genes that share phenotypes with ARV1: view

Animal Model Products

miRNA for ARV1 Gene

miRTarBase miRNAs that target ARV1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARV1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ARV1 Gene

Localization for ARV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARV1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARV1 Gene COMPARTMENTS Subcellular localization image for ARV1 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IBA --
GO:0016021 integral component of membrane IEA --
GO:0032541 cortical endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with ARV1: view

Pathways & Interactions for ARV1 Gene

genes like me logo Genes that share pathways with ARV1: view

Pathways by source for ARV1 Gene

Gene Ontology (GO) - Biological Process for ARV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process IBA --
GO:0006695 cholesterol biosynthetic process TAS --
GO:0008206 bile acid metabolic process IEA --
GO:0016125 sterol metabolic process IBA --
GO:0030301 cholesterol transport IEA --
genes like me logo Genes that share ontologies with ARV1: view

No data available for SIGNOR curated interactions for ARV1 Gene

Drugs & Compounds for ARV1 Gene

No Compound Related Data Available

Transcripts for ARV1 Gene

Unigene Clusters for ARV1 Gene

ARV1 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARV1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARV1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - -
SP2: -
SP3: -
SP4: -
SP5:
SP6: - - -
SP7: - - -

Relevant External Links for ARV1 Gene

GeneLoc Exon Structure for
ARV1
ECgene alternative splicing isoforms for
ARV1

Expression for ARV1 Gene

mRNA expression in normal human tissues for ARV1 Gene

Protein differential expression in normal tissues from HIPED for ARV1 Gene

This gene is overexpressed in Testis (33.5), Placenta (19.0), and Islet of Langerhans (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ARV1 Gene



SOURCE GeneReport for Unigene cluster for ARV1 Gene Hs.275736

genes like me logo Genes that share expression patterns with ARV1: view

Protein tissue co-expression partners for ARV1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARV1 Gene

Orthologs for ARV1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARV1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARV1 35
  • 86.96 (n)
  • 85.98 (a)
ARV1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARV1 35
  • 88.44 (n)
  • 87.45 (a)
ARV1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arv1 35
  • 80.33 (n)
  • 79.7 (a)
Arv1 16
Arv1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARV1 35
  • 99.26 (n)
  • 99.55 (a)
ARV1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arv1 35
  • 78.15 (n)
  • 80.15 (a)
oppossum
(Monodelphis domestica)
Mammalia ARV1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARV1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARV1 35
  • 75.88 (n)
  • 76.32 (a)
ARV1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARV1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arv1 35
  • 71.08 (n)
  • 75.8 (a)
Str.3754 35
zebrafish
(Danio rerio)
Actinopterygii arv1 35
  • 63.07 (n)
  • 67.14 (a)
Dr.11447 35
arv1 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7932 35
fruit fly
(Drosophila melanogaster)
Insecta CG32442 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R05H5.5 36
  • 25 (a)
OneToOne
Species with no ortholog for ARV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARV1 Gene

ENSEMBL:
Gene Tree for ARV1 (if available)
TreeFam:
Gene Tree for ARV1 (if available)

Paralogs for ARV1 Gene

(5) SIMAP similar genes for ARV1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARV1: view

No data available for Paralogs for ARV1 Gene

Variants for ARV1 Gene

Sequence variations from dbSNP and Humsavar for ARV1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3206802 -- 230,995,536(+) TGTTT(C/G)TGAAA intron-variant
rs4846889 -- 230,993,685(+) AGCTC(A/G)GAAGT intron-variant
rs5781616 -- 230,985,921(+) CAGAA(-/T/TT/TTT)TTTTT intron-variant
rs6419490 -- 230,982,518(+) CACTT(A/C)CCCCC intron-variant
rs6541248 -- 230,989,228(+) CTACC(C/T)CCTGG intron-variant

Variation tolerance for ARV1 Gene

Residual Variation Intolerance Score: 28.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARV1 Gene

HapMap Linkage Disequilibrium report
ARV1
Human Gene Mutation Database (HGMD)
ARV1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARV1 Gene

Disorders for ARV1 Gene

Relevant External Links for ARV1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARV1
genes like me logo Genes that share disorders with ARV1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARV1 Gene

Publications for ARV1 Gene

  1. Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. (PMID: 20663892) Tong F. … Rader D.J. (J. Biol. Chem. 2010) 2 67
  2. Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. (PMID: 12145310) Swain E. … Nickels J.T. Jr. (J. Biol. Chem. 2002) 2 67
  3. Mutations in yeast ARV1 alter intracellular sterol distribution and are complemented by human ARV1. (PMID: 11063737) Tinkelenberg A.H. … Sturley S.L. (J. Biol. Chem. 2000) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance. (PMID: 24273168) Ruggles K.V. … Sturley S.L. (J. Biol. Chem. 2014) 67

Products for ARV1 Gene

Sources for ARV1 Gene

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