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Aliases for ARTN Gene

Aliases for ARTN Gene

  • Artemin 2 3
  • Neublastin 2 3 4
  • Neurotrophic Factor 2 3
  • ENOVIN 3 4
  • EVN 3 4
  • NBN 3

External Ids for ARTN Gene

Summaries for ARTN Gene

Entrez Gene Summary for ARTN Gene

  • The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ARTN Gene

ARTN (Artemin) is a Protein Coding gene. Diseases associated with ARTN include pancreatic cancer and spinal cord injury. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is PSPN.

UniProtKB/Swiss-Prot for ARTN Gene

  • Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyers patch-like structures, a major component of the gut-associated lymphoid tissue.

Gene Wiki entry for ARTN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARTN Gene

Genomics for ARTN Gene

Genomic Location for ARTN Gene

Start:
43,933,320 bp from pter
End:
43,937,241 bp from pter
Size:
3,922 bases
Orientation:
Plus strand

Genomic View for ARTN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARTN Gene

Regulatory Elements for ARTN Gene

Proteins for ARTN Gene

  • Protein details for ARTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4W7-ARTN_HUMAN
    Recommended name:
    Artemin
    Protein Accession:
    Q5T4W7
    Secondary Accessions:
    • D3DPY1
    • D3DPY3
    • O95441
    • O96030
    • Q6P6A3

    Protein attributes for ARTN Gene

    Size:
    220 amino acids
    Molecular mass:
    22878 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Binds to RET (By similarity).

    Three dimensional structures from OCA and Proteopedia for ARTN Gene

    Alternative splice isoforms for ARTN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARTN Gene

Proteomics data for ARTN Gene at MOPED

Post-translational modifications for ARTN Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser60 and Asn202

No data available for DME Specific Peptides for ARTN Gene

Domains for ARTN Gene

Gene Families for ARTN Gene

HGNC:

UniProtKB/Swiss-Prot:

ARTN_HUMAN
Family:
  • Belongs to the TGF-beta family. GDNF subfamily.:
    • Q5T4W7
genes like me logo Genes that share domains with ARTN: view

Function for ARTN Gene

Molecular function for ARTN Gene

UniProtKB/Swiss-Prot Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyers patch-like structures, a major component of the gut-associated lymphoid tissue.

Gene Ontology (GO) - Molecular Function for ARTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9883723
GO:0005515 protein binding --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with ARTN: view
genes like me logo Genes that share phenotypes with ARTN: view

miRNA for ARTN Gene

miRTarBase miRNAs that target ARTN

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARTN Gene

Localization for ARTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARTN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARTN Gene COMPARTMENTS Subcellular localization image for ARTN gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with ARTN: view

Pathways for ARTN Gene

genes like me logo Genes that share pathways with ARTN: view

Gene Ontology (GO) - Biological Process for ARTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9883723
GO:0007405 neuroblast proliferation TAS 9883723
GO:0007411 axon guidance TAS --
GO:0007422 peripheral nervous system development IEA --
GO:0050930 induction of positive chemotaxis IEA --
genes like me logo Genes that share ontologies with ARTN: view

Compounds for ARTN Gene

(4) Novoseek inferred chemical compound relationships for ARTN Gene

Compound -log(P) Hits PubMed IDs
tyrosine 48.4 4
6-hydroxydopamine 30.5 1
heparan sulfate 28.2 2
dopamine 11.8 2
genes like me logo Genes that share compounds with ARTN: view

Transcripts for ARTN Gene

Unigene Clusters for ARTN Gene

Artemin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARTN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for ARTN Gene

GeneLoc Exon Structure for
ARTN
ECgene alternative splicing isoforms for
ARTN

Expression for ARTN Gene

mRNA expression in normal human tissues for ARTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARTN Gene

This gene is overexpressed in Prostate (4.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ARTN Gene

SOURCE GeneReport for Unigene cluster for ARTN Gene Hs.632404

mRNA Expression by UniProt/SwissProt for ARTN Gene

Q5T4W7-ARTN_HUMAN
Tissue specificity: Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain.
genes like me logo Genes that share expressions with ARTN: view

Orthologs for ARTN Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARTN 36
  • 99.42 (n)
  • 98.68 (a)
ARTN 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARTN 36
  • 88.58 (n)
  • 87.64 (a)
ARTN 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARTN 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Artn 36
  • 80.15 (n)
  • 75.91 (a)
Artn 16
Artn 37
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARTN 37
  • 27 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARTN 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Artn 36
  • 80.76 (n)
  • 78.18 (a)
lizard
(Anolis carolinensis)
Reptilia ARTN 37
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii artna 37
  • 48 (a)
OneToOne
Species with no ortholog for ARTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARTN Gene

ENSEMBL:
Gene Tree for ARTN (if available)
TreeFam:
Gene Tree for ARTN (if available)

Paralogs for ARTN Gene

Paralogs for ARTN Gene

Selected SIMAP similar genes for ARTN Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARTN: view

Variants for ARTN Gene

Sequence variations from dbSNP and Humsavar for ARTN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1548634 -- 43,933,936(+) CGCTC(C/T)TGGGC intron-variant, upstream-variant-2KB
rs1766968 -- 43,937,370(-) CGAAG(A/G)TCCAG downstream-variant-500B
rs1859727 -- 43,932,709(+) GGAGC(C/T)GGGAT upstream-variant-2KB
rs2242637 - 43,935,712(+) TAGGC(A/G)GCAGG reference, missense, upstream-variant-2KB, utr-variant-5-prime
rs2428958 -- 43,933,504(-) TAGAC(A/T)CGCGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ARTN Gene

Variant ID Type Subtype PubMed ID
nsv870942 CNV Loss 21882294

Relevant External Links for ARTN Gene

HapMap Linkage Disequilibrium report
ARTN

Disorders for ARTN Gene

(1) University of Copenhagen DISEASES for ARTN Gene

(6) Novoseek inferred disease relationships for ARTN Gene

Disease -log(P) Hits PubMed IDs
hirschsprung disease 62.3 1
neurodegenerative diseases 26.1 2
parkinson disease 25.1 1
pancreatic cancer 12.5 2
tumors 0 4

Relevant External Links for ARTN

Genetic Association Database (GAD)
ARTN
Human Genome Epidemiology (HuGE) Navigator
ARTN
genes like me logo Genes that share disorders with ARTN: view

No data available for UniProtKB/Swiss-Prot for ARTN Gene

Publications for ARTN Gene

  1. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. (PMID: 9883723) Baloh R.H. … Milbrandt J. (Neuron 1998) 2 3 4 23
  2. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. (PMID: 16765900) Wang X. … Garcia K.C. (Structure 2006) 3 4 23
  3. In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. (PMID: 10673327) Rosenblad C. … Johansen T.E. (Mol. Cell. Neurosci. 2000) 3 4 23
  4. Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants. (PMID: 10583383) Masure S. … Gordon R.D. (Eur. J. Biochem. 1999) 3 4 23
  5. Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease. (PMID: 18970938) Fernandez R.M. … Borrego S. (J. Pediatr. Surg. 2008) 3 23 49

Products for ARTN Gene

Sources for ARTN Gene

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