External Ids for ARTN Gene
Previous GeneCards Identifiers for ARTN Gene
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for ARTN Gene
ARTN (Artemin) is a Protein Coding gene. Diseases associated with ARTN include hirschsprung disease 1 and parkinson disease, late-onset. Among its related pathways are Developmental Biology and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is PSPN.
UniProtKB/Swiss-Prot for ARTN Gene
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyers patch-like structures, a major component of the gut-associated lymphoid tissue.