Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARTN Gene

protein-coding   GIFtS: 65
GCID: GC01P044398

Artemin

  See ARTN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
artemin1 2     ENOVIN2
neublastin1 2     NBN2
Neurotrophic Factor1 2     Enovin3
EVN2 3     Neublastin3

External Ids:    HGNC: 7271   Entrez Gene: 90482   Ensembl: ENSG000001174077   OMIM: 6038865   UniProtKB: Q5T4W73   

Export aliases for ARTN gene to outside databases

Previous GC identifers: GC01P044237 GC01P043399 GC01P043828 GC01P043812 GC01P044068 GC01P044171 GC01P042517


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ARTN Gene:
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of
ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in
having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has
been shown in culture to support the survival of a number of peripheral neuron populations and at least one
population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression
pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as
a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Oct 2008)

GeneCards Summary for ARTN Gene:
ARTN (artemin) is a protein-coding gene. Diseases associated with ARTN include spinal cord injury, and hirschsprung's disease. GO annotations related to this gene include growth factor activity and receptor binding. An important paralog of this gene is GDNF.

UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7
Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor
complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the
survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus
promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue

Gene Wiki entry for ARTN (Artemin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARTN gene promoter:
         Egr-2   MZF-1   AP-4   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARTN promoter sequence
   Search Chromatin IP Primers for ARTN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p33-p32

ARTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARTN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P044398:  view genomic region     (about GC identifiers)

Start:
44,398,992 bp from pter      End:
44,402,913 bp from pter
Size:
3,922 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7 (See protein sequence)
Recommended Name: Artemin precursor  
Size: 220 amino acids; 22878 Da
Subunit: Homodimer; disulfide-linked. Binds to RET (By similarity)
Developmental stage: Expressed during embryogenesis. High level expression seen in fetal kidney and lung while a
low level expression seen in the fetal brain
4 PDB 3D structures from and Proteopedia for ARTN:
2ASK (3D)        2GH0 (3D)        2GYR (3D)        2GYZ (3D)    
Secondary accessions: D3DPY1 D3DPY3 O95441 O96030 Q6P6A3
Alternative splicing: 3 isoforms:  Q5T4W7-1   Q5T4W7-2   Q5T4W7-3   

Explore the universe of human proteins at neXtProt for ARTN: NX_Q5T4W7

Explore proteomics data for ARTN at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser60, Asn202
  • Modification sites at PhosphoSitePlus

  • See ARTN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129687.1  NP_476431.2  NP_476432.2  

    ENSEMBL proteins: 
     ENSP00000361434   ENSP00000434784   ENSP00000435804   ENSP00000436727   ENSP00000436149  
     ENSP00000434071   ENSP00000435140   ENSP00000434856   ENSP00000361429   ENSP00000391998  
     ENSP00000387435  
    Reactome Protein details: Q5T4W7

    ARTN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ARTN (Artemin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ARTN
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ARTN
    GenScript Custom Purified and Recombinant Proteins Services for ARTN
    Novus Biologicals ARTN Proteins
    Novus Biologicals ARTN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ARTN
    Cloud-Clone Corp. Proteins for ARTN

     
    Search eBioscience for Proteins for ARTN 

    ARTN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ARTN (Artemin)
    OriGene Antibodies for ARTN
    OriGene Custom Antibody Services for ARTN
    Novus Biologicals ARTN Antibodies
    Abcam antibodies for ARTN
    Cloud-Clone Corp. Antibodies for ARTN
    ThermoFisher Antibodies for ARTN
    LSBio Antibodies in human, mouse, rat for ARTN

    ARTN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARTN
    R&D Systems ELISAs for ARTN (Artemin)         (see all)
    GenScript Custom Assay Services for ARTN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARTN
    Cloud-Clone Corp. CLIAs for ARTN
    Search eBioscience for ELISAs for ARTN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR001839 TGF-b_C

    Graphical View of Domain Structure for InterPro Entry Q5T4W7

    ProtoNet protein and cluster: Q5T4W7

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7
    Similarity: Belongs to the TGF-beta family. GDNF subfamily


    Find genes that share domains with ARTN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARTN_HUMAN, Q5T4W7
    Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor
    complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the
    survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus
    promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9883723
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with ARTN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARTN:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Artn):
     nervous system  vision/eye 

    Find genes that share phenotypes with ARTN           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARTN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARTN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARTN

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARTN:
    hsa-mir-223-3p (MIRT006682)

    Block miRNA regulation of human, mouse, rat ARTN using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ARTN:
    hsa-miR-3121-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidARTN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARTN
    Predesigned siRNA for gene silencing in human, mouse, rat ARTN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARTN

    Clone
    Products:
         
    OriGene clones in human, mouse for ARTN (see all 24)
    OriGene ORF clones in mouse, rat for ARTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARTN (NM_057090)
    Sino Biological Human cDNA Clone for ARTN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARTN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARTN
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARTN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARTN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ARTN_HUMAN, Q5T4W7: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with ARTN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ARTN About    
    See pathways by source

    SuperPathContained pathways About
    1Development EGFR signaling pathway
    Development GDNF family signaling0.45
    GDNF-Family Ligands and Receptor Interactions0.41
    2L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    3NCAM signaling for neurite out-growth
    NCAM1 interactions0.59
    NCAM signaling for neurite out-growth0.59


    Find genes that share SuperPaths with ARTN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ARTN
        GDNF-Family Ligands and Receptor Interactions

    1 GeneGo (Thomson Reuters) Pathway for ARTN
        Development GDNF family signaling


    1 Reactome Pathway for ARTN
        NCAM1 interactions


        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARTN: 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ARTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARTN (Q5T4W73 ENSP000003919984) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFRA3O606093, ENSP000002747214I2D: score=2 STRING: ENSP00000274721
    ENSG00000235925ENSP000004094284STRING: ENSP00000409428
    GDNFENSP000003171454STRING: ENSP00000317145
    GFRA1ENSP000003937254STRING: ENSP00000393725
    IRS1ENSP000003048954STRING: ENSP00000304895
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9883723
    GO:0007405neuroblast proliferation TAS9883723
    GO:0007411axon guidance TAS--
    GO:0007422peripheral nervous system development IEA--
    GO:0050930induction of positive chemotaxis IEA--

    Find genes that share ontologies with ARTN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARTN

    4 Novoseek inferred chemical compound relationships for ARTN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 48.4 4 16734417 (1), 10484767 (1), 11222636 (1), 11544105 (1)
    6-hydroxydopamine 30.5 1 11043566 (1)
    heparan sulfate 28.2 2 16734417 (1), 16709187 (1)
    dopamine 11.8 3 10673327 (1), 12953054 (1)



    Find genes that share compounds with ARTN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARTN gene (5 alternative transcripts): 
    NM_001136215.1  NM_057090.2  NM_057091.2  NM_003976.3  NM_057160.2  

    Unigene Cluster for ARTN:

    Artemin
    Hs.632404  [show with all ESTs]
    Unigene Representative Sequence: NM_057090
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372359(uc001cks.3) ENST00000477048 ENST00000471394 ENST00000498139(uc001cku.3 uc001ckw.3)
    ENST00000491846 ENST00000479128 ENST00000472435 ENST00000474592 ENST00000372354
    ENST00000438616 ENST00000414809(uc001ckv.3 uc001ckt.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARTN using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate ARTN:
    hsa-miR-3121-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidARTN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARTN
    Predesigned siRNA for gene silencing in human, mouse, rat ARTN
    Clone
    Products:
         
    OriGene clones in human, mouse for ARTN (see all 24)
    OriGene ORF clones in mouse, rat for ARTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARTN (NM_057090)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARTN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARTN
    OriGene qSTAR qPCR primer pairs in human, mouse for ARTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARTN
      QuantiTect SYBR Green Assays in human, mouse, rat ARTN
      QuantiFast Probe-based Assays in human, mouse, rat ARTN

    Additional mRNA sequence: 

    AF109401.1 AF120274.1 BC062375.1 

    6 DOTS entries:

    DT.101980137  DT.40216700  DT.91699435  DT.95158250  DT.40233398  DT.75101766 

    Selected AceView cDNA sequences (see all 38):

    AF109401 BF063378 AW203993 NM_057160 AI935302 BC062375 AW137020 AW207099 
    AF120274 AW206576 AI695822 AI225050 AW611702 BM981370 AW138964 AI424604 
    BQ129389 NM_057091 AW293171 BP353368 AI829054 BQ129248 BF507803 AI768514 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARTN    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:                          -     -           -         
    SP2:                    -     -     -                     
    SP3:                                                      
    SP4:                                            -         


    ECgene alternative splicing isoforms for ARTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCTGGCC
    ARTN Expression
    About this image


    ARTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Eye (Sensory Organs)
             Retina
     
     Dermis (Integumentary System)
    ARTN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARTN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632404

    UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7
    Tissue specificity: Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta,
    pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARTN: 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARTN
    OriGene qSTAR qPCR primer pairs in human, mouse for ARTN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARTN
    QuantiTect SYBR Green Assays in human, mouse, rat ARTN
    QuantiFast Probe-based Assays in human, mouse, rat ARTN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ARTN gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Artn1 , 5 artemin1, 5 80.15(n)1
    75.91(a)1
      4 (53.83 cM)5
    118761  NM_009711.41  NP_033841.11 
     1179261625 
    lizard
    (Anolis carolinensis)
    Reptilia ARTN6
    artemin
    46(a)
    1 ↔ 1
    4(108783127-108783909)
    zebrafish
    (Danio rerio)
    Actinopterygii artna6
    artemin a
    48(a)
    1 ↔ 1
    6(3266343-3266657) ENSDARG00000096252


    ENSEMBL Gene Tree for ARTN (if available)
    TreeFam Gene Tree for ARTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARTN gene
    GDNF2  PSPN2  NRTN2  
    1 SIMAP similar gene for ARTN using alignment to 5 protein entries:     ARTN_HUMAN (see all proteins):
    PSPN

    Find genes that share paralogs with ARTN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARTN (see all 112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388630281,2
    --44397366(+) CCCCAA/GCATCC 3 -- us2k10--------
    rs1419940531,2
    --44397432(+) AGTGAC/GCTTTC 3 -- us2k10--------
    rs1877649731,2
    --44397480(+) TGGCCA/GGCTCC 3 -- us2k10--------
    rs1508194021,2
    --44397702(+) CCTCCA/GTTTCT 3 -- us2k10--------
    rs1381222431,2
    --44397745(+) CCTGCA/CTGGAT 3 -- us2k10--------
    rs1170653651,2
    F--44397846(+) GCAGCC/TGGTTG 3 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1924798581,2
    --44397847(+) CAGCCA/GGTTGT 3 -- us2k10--------
    rs1493293741,2
    --44397881(+) CCCTGC/TTTGGC 3 -- us2k10--------
    rs1166934141,2
    F--44397932(+) CACCAC/ACTCCA 3 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1844769911,2
    --44397944(+) CAGCAG/TTTCTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARTN (44398992 - 44402913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARTN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870942CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARTN
    DNA2.0 Custom Variant and Variant Library Synthesis for ARTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603886    OMIM disorders: --

    4 diseases for ARTN:    
    About MalaCards
    spinal cord injury    hirschsprung's disease    non-small cell lung carcinoma    pancreatic cancer

    1 disease from the University of Copenhagen DISEASES database for ARTN:
    Hirschsprung's disease

    Find genes that share disorders with ARTN           About GenesLikeMe

    6 Novoseek inferred disease relationships for ARTN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hirschsprung disease 62.3 1 18970938 (1)
    neurodegenerative diseases 26.1 3 10583383 (1), 10652334 (1)
    parkinson disease 25.1 1 17218019 (1)
    pancreatic cancer 12.5 2 16269310 (1), 16858191 (1)
    tumors 0 8 20118197 (2), 12679485 (1), 19363524 (1)
    cancer 0 5 16858191 (4)

    Genetic Association Database (GAD): ARTN
    Human Genome Epidemiology (HuGE) Navigator: ARTN (1 document)

    Export disorders for ARTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARTN gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with ARTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. (PubMed id 9883723)1, 2, 3, 9 Baloh R.H....Milbrandt J. (Neuron 1998)
    2. Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants. (PubMed id 10583383)1, 2, 9 Masure S.... Gordon R.D. (Eur. J. Biochem. 1999)
    3. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. (PubMed id 16765900)1, 2, 9 Wang X.... Garcia K.C. (Structure 2006)
    4. In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. (PubMed id 10673327)1, 2, 9 Rosenblad C....Johansen T.E. (Mol. Cell. Neurosci. 2000)
    5. Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease. (PubMed id 18970938)1, 4, 9 Fernandez R.M....Borrego S. (J. Pediatr. Surg. 2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Artemin is estrogen regulated and mediates antiestrogen resistance in mammary carcinoma. (PubMed id 20305694)1, 9 Kang J....Lobie P.E. (Oncogene 2010)
    9. Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells. (PubMed id 20118197)1, 9 Pandey V....Lobie P.E. (Endocrinology 2010)
    10. Artemin is oncogenic for human mammary carcinoma cells. (PubMed id 19363524)1, 9 Kang J....Lobie P.E. (Oncogene 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9048 HGNC: 727 AceView: ARTN Ensembl:ENSG00000117407 euGenes: HUgn9048
    ECgene: ARTN H-InvDB: ARTN

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARTN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARTN gene:
    Search GeneIP for patents involving ARTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for ARTN (Artemin)   Browse Cell Culture Products  
     ELISAs for ARTN (Artemin)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for ARTN (Artemin)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for ARTN (Artemin)  
     OriGene Antibodies for ARTN   OriGene RNAi products in human, mouse, rat for ARTN  
     OriGene qPCR primer pairs and template standards for ARTN   OriGene Protein Over-expression Lysate for ARTN  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARTN  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARTN   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARTN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARTN   OriGene Custom Protein Services for ARTN  

     
     
     Block miRNA regulation of human, mouse, rat ARTN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARTN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARTN Predesigned siRNA for gene silencing in human, mouse, rat ARTN
     QuantiFast Probe-based Assays in human, mouse, rat ARTN QuantiTect SYBR Green Assays in human, mouse, rat ARTN
     PCR Arrays including human, mouse, rat ARTN Search Chromatin IP Primers for ARTN
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARTN  Search GeneGlobe Interaction Network for ARTN
     Regulatory tfbs in ARTN promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARTN GenScript cDNA clones with any tag delivered in your preferred vector for ARTN
     GenScript Custom Assay Services for ARTN GenScript Custom overexpressing Cell Line Services for ARTN
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ARTN
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ARTN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARTN antibodies
     ARTN proteins
     ARTN lysates
     Antibodies for ARTN
     See all of Abcam's Antibodies, Kits and Proteins for ARTN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ARTN
     Proteins for ARTN
     Antibodies for ARTN
     ELISAs for ARTN
     CLIAs for ARTN



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARTN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARTN
     SwitchGear 3'UTR luciferase reporter plasmids for ARTN
     SwitchGear Promoter luciferase reporter plasmids for ARTN
     ThermoFisher Antibodies for ARTN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARTN
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARTN
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARTN
     LSBio Antibodies in human, mouse, rat for ARTN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ARTN
      Search eBioscience for proteins for ARTN
      Search eBioscience for elisas for ARTN
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARTN gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4