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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARTN Gene

protein-coding   GIFtS: 64
GCID: GC01P044398

Artemin

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
artemin1 2     ENOVIN2
neublastin1 2     NBN2
Neurotrophic Factor1 2     Enovin3
EVN2 3     Neublastin3

External Ids:    HGNC: 7271   Entrez Gene: 90482   Ensembl: ENSG000001174077   OMIM: 6038865   UniProtKB: Q5T4W73   

Export aliases for ARTN gene to outside databases

Previous GC identifers: GC01P044237 GC01P043399 GC01P043828 GC01P043812 GC01P044068 GC01P044171 GC01P042517


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARTN Gene:
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of
ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in
having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has
been shown in culture to support the survival of a number of peripheral neuron populations and at least one
population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression
pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as
a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Oct 2008)

GeneCards Summary for ARTN Gene: 
ARTN (artemin) is a protein-coding gene. Diseases associated with ARTN include burning mouth syndrome, and spinal cord injury, and among its related super-pathways are Development EGFR signaling pathway and Axon guidance. GO annotations related to this gene include growth factor activity and receptor binding. An important paralog of this gene is GDNF.

UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7
Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor
complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the
survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus
promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue

Gene Wiki entry for ARTN (Artemin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARTN gene promoter:
         Egr-2   MZF-1   AP-4   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARTN promoter sequence
   Search SABiosciences Chromatin IP Primers for ARTN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p33-p32

ARTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARTN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P044398:  view genomic region     (about GC identifiers)

Start:
44,398,992 bp from pter      End:
44,402,913 bp from pter
Size:
3,922 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7 (See protein sequence)
Recommended Name: Artemin precursor  
Size: 220 amino acids; 22878 Da
Subunit: Homodimer; disulfide-linked. Binds to RET (By similarity)
Subcellular location: Secreted (By similarity)
Developmental stage: Expressed during embryogenesis. High level expression seen in fetal kidney and lung while a
low level expression seen in the fetal brain
4 PDB 3D structures from and Proteopedia for ARTN:
2ASK (3D)        2GH0 (3D)        2GYR (3D)        2GYZ (3D)    
Secondary accessions: D3DPY1 D3DPY3 O95441 O96030 Q6P6A3
Alternative splicing: 3 isoforms:  Q5T4W7-1   Q5T4W7-2   Q5T4W7-3   

Explore the universe of human proteins at neXtProt for ARTN: NX_Q5T4W7

Explore proteomics data for ARTN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T4W7

  • ARTN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARTN Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001129687.1  NP_476431.2  NP_476432.2  

    ENSEMBL proteins: 
     ENSP00000361434   ENSP00000434784   ENSP00000435804   ENSP00000436727   ENSP00000436149  
     ENSP00000434071   ENSP00000435140   ENSP00000434856   ENSP00000361429   ENSP00000391998  
     ENSP00000387435  
    Reactome Protein details: Q5T4W7
    Human Recombinant Protein Products for ARTN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ARTN (Artemin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ARTN
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ARTN
    GenScript Custom Purified and Recombinant Proteins Services for ARTN
    Novus Biologicals ARTN Proteins
    Novus Biologicals ARTN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ARTN
    Cloud-Clone Corp. Proteins for ARTN 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    ARTN for ontologies           About GeneDecksing



    ARTN Antibody Products: 
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    Novus Biologicals ARTN Antibodies
    Abcam antibodies for ARTN
    Cloud-Clone Corp. Antibodies for ARTN 
    ThermoFisher Antibodies for ARTN
    LSBio Antibodies in human, mouse, rat for ARTN 

    Assay Products for ARTN: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for ARTN (Artemin)         (see all)
    GenScript Custom Assay Services for ARTN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARTN 
    Cloud-Clone Corp. CLIAs for ARTN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001839 TGF-b_C

    Graphical View of Domain Structure for InterPro Entry Q5T4W7

    ProtoNet protein and cluster: Q5T4W7

    2 Blocks protein domains:
    IPB001839 Transforming growth factor beta (TGFb)
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7
    Similarity: Belongs to the TGF-beta family. GDNF subfamily


    ARTN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARTN_HUMAN, Q5T4W7
    Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor
    complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the
    survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus
    promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9883723
    GO:0005515protein binding ----
    GO:0008083growth factor activity IEA--
         
    ARTN for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARTN:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Artn):
     nervous system  vision/eye 

    ARTN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARTN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARTN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARTN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARTN
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ARTN:
    hsa-miR-3121-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidARTN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARTN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARTN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARTN
    Sirion Biotech Customized adenovirus for overexpression of ARTN

    Clone
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    OriGene clones in human, mouse for ARTN (see all 20)
    OriGene ORF clones in mouse, rat for ARTN
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    GenScript: all cDNA clones in your preferred vector (see all 3): ARTN (NM_057090)
    Sino Biological Human cDNA Clone for ARTN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARTN
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                         Customized lentivirus expression plasmids for stable overexpression of ARTN 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARTN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARTN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development EGFR signaling pathway
    Development GDNF family signaling0.45
    GDNF-Family Ligands and Receptor Interactions0.41
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3NCAM signaling for neurite out-growth
    NCAM signaling for neurite out-growth0.62
    NCAM1 interactions0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ARTN
        Development GDNF family signaling

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ARTN
        GDNF-Family Ligands and Receptor Interactions

    1 GeneGo (Thomson Reuters) Pathway for ARTN
        Development GDNF family signaling


    4        Reactome Pathways for ARTN
        Developmental Biology
    NCAM1 interactions
    NCAM signaling for neurite out-growth
    Axon guidance



    ARTN for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for ARTN (Q5T4W73 ENSP000003919984) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFRA3O606093, ENSP000002747214I2D: score=2 STRING: ENSP00000274721
    GDNFENSP000003171454STRING: ENSP00000317145
    GFRA1ENSP000003937254STRING: ENSP00000393725
    IRS1ENSP000003048954STRING: ENSP00000304895
    NCAM1ENSP000003184724STRING: ENSP00000318472
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9883723
    GO:0007405neuroblast proliferation TAS9883723
    GO:0007411axon guidance TAS--
    GO:0007422peripheral nervous system development IEA--
    GO:0050930induction of positive chemotaxis IEA--

    ARTN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARTN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARTN

    4 Novoseek inferred chemical compound relationships for ARTN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 48.4 4 16734417 (1), 10484767 (1), 11222636 (1), 11544105 (1)
    6-hydroxydopamine 30.5 1 11043566 (1)
    heparan sulfate 28.2 2 16734417 (1), 16709187 (1)
    dopamine 11.8 3 10673327 (1), 12953054 (1)

    Search CenterWatch for drugs/clinical trials and news about ARTN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARTN gene (5 alternative transcripts): 
    NM_001136215.1  NM_057090.2  NM_057091.2  NM_003976.3  NM_057160.2  

    Unigene Cluster for ARTN:

    Artemin
    Hs.632404  [show with all ESTs]
    Unigene Representative Sequence: NM_057090
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372359(uc001cks.3) ENST00000477048 ENST00000471394 ENST00000498139(uc001cku.3 uc001ckw.3)
    ENST00000491846 ENST00000479128 ENST00000472435 ENST00000474592 ENST00000372354
    ENST00000438616 ENST00000414809(uc001ckv.3 uc001ckt.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARTN
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ARTN:
    hsa-miR-3121-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidARTN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARTN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARTN
    Clone
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    OriGene clones in human, mouse for ARTN (see all 20)
    OriGene ORF clones in mouse, rat for ARTN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARTN (NM_057090)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARTN
    Sirion Biotech Customized lentivirus for stable overexpression of ARTN 
                         Customized lentivirus expression plasmids for stable overexpression of ARTN 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARTN
    OriGene qSTAR qPCR primer pairs in human, mouse for ARTN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARTN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARTN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARTN

    Additional mRNA sequence: 

    AF109401.1 AF120274.1 BC062375.1 

    6 DOTS entries:

    DT.101980137  DT.40216700  DT.91699435  DT.95158250  DT.40233398  DT.75101766 

    24/38 AceView cDNA sequences (see all 38):

    BC062375 AF109401 AW137020 NM_057160 AI935302 AW203993 BF063378 BP353368 
    AW138964 NM_057091 AW293171 AI695822 BF507803 BX091939 AI225050 AW206576 
    AW207099 NM_057090 AI829054 AI768514 BM981370 BQ129248 NM_003976 BQ129389 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARTN    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:                          -     -           -         
    SP2:                    -     -     -                     
    SP3:                                                      
    SP4:                                            -         


    ECgene alternative splicing isoforms for ARTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARTN expression in normal human tissues (normalized intensities)      ARTN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCTGGCC
    ARTN Expression
    About this image


    ARTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Epidermis (Integumentary System)
             Human EpiDermal Keratinocytes (HEK)   
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Blood (Extraembryonic Tissues)
             umbilical cord reticulocytes   

    See ARTN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARTN

    SOURCE GeneReport for Unigene cluster: Hs.632404

    UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7
    Tissue specificity: Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta,
    pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including ARTN: 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ARTN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARTN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARTN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARTN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ARTN gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Artn1 , 5 artemin1, 5 81.06(n)1
    77.27(a)1
      4 (53.83 cM)5
    118761  NM_009711.31  NP_033841.11 
     1179261625 
    chicken
    (Gallus gallus)
    Aves LOC1008579101 uncharacterized LOC100857910 54.27(n)
    46.38(a)
      100857910  XM_003641685.1  XP_003641733.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARTN6
    Uncharacterized protein
    46(a)
    1 ↔ 1
    4(108783127-108783909)
    zebrafish
    (Danio rerio)
    Actinopterygii artna6
    artemin a
    47(a)
    1 ↔ 1
    6(3266343-3266657)


    ENSEMBL Gene Tree for ARTN (if available)
    TreeFam Gene Tree for ARTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARTN gene
    GDNF2  PSPN2  NRTN2  
    1 SIMAP similar gene for ARTN using alignment to 5 protein entries:     ARTN_HUMAN (see all proteins):
    PSPN

    ARTN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/112 SNPs in ARTN are shown (see all 112)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388630281,2
    --44397366(+) CCCCAA/GCATCC 3 -- us2k10--------
    rs1419940531,2
    --44397432(+) AGTGAC/GCTTTC 3 -- us2k10--------
    rs1877649731,2
    --44397480(+) TGGCCA/GGCTCC 3 -- us2k10--------
    rs1508194021,2
    --44397702(+) CCTCCA/GTTTCT 3 -- us2k10--------
    rs1381222431,2
    --44397745(+) CCTGCA/CTGGAT 3 -- us2k10--------
    rs1170653651,2
    F--44397846(+) GCAGCC/TGGTTG 3 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1924798581,2
    --44397847(+) CAGCCA/GGTTGT 3 -- us2k10--------
    rs1493293741,2
    --44397881(+) CCCTGC/TTTGGC 3 -- us2k10--------
    rs1166934141,2
    F--44397932(+) CACCAC/ACTCCA 3 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1844769911,2
    --44397944(+) CAGCAG/TTTCTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARTN (44398992 - 44402913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARTN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv870942CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603886    OMIM disorders: --

    16 diseases for ARTN:    About MalaCards
    burning mouth syndrome    spinal cord injury    hirschsprung's disease    pancreatic cancer
    parkinson's disease    neuronitis    endometrial carcinoma    pancreatitis
    esophagitis    atopic dermatitis    neuropathy    dermatitis
    thyroiditis    endotheliitis    adenocarcinoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ARTN:
    Hirschsprung's disease

    ARTN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for ARTN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hirschsprung disease 62.3 1 18970938 (1)
    neurodegenerative diseases 26.1 3 10583383 (1), 10652334 (1)
    parkinson disease 25.1 1 17218019 (1)
    pancreatic cancer 12.5 2 16269310 (1), 16858191 (1)
    tumors 0 8 20118197 (2), 12679485 (1), 19363524 (1)
    cancer 0 5 16858191 (4)

    Genetic Association Database (GAD): ARTN
    Human Genome Epidemiology (HuGE) Navigator: ARTN (1 document)

    Export disorders for ARTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARTN gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with ARTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. (PubMed id 9883723)1, 2, 3, 9 Baloh R.H....Milbrandt J. (1998)
    2. Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants. (PubMed id 10583383)1, 2, 9 Masure S.... Gordon R.D. (1999)
    3. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. (PubMed id 16765900)1, 2, 9 Wang X.... Garcia K.C. (2006)
    4. In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. (PubMed id 10673327)1, 2, 9 Rosenblad C....Johansen T.E. (2000)
    5. Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease. (PubMed id 18970938)1, 4, 9 Fernandez R.M....Borrego S. (2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Artemin is estrogen regulated and mediates antiestrog en resistance in mammary carcinoma. (PubMed id 20305694)1, 9 Kang J....Lobie P.E. (2010)
    9. Artemin stimulates oncogenicity and invasiveness of h uman endometrial carcinoma cells. (PubMed id 20118197)1, 9 Pandey V....Lobie P.E. (2010)
    10. Artemin is oncogenic for human mammary carcinoma cells. (PubMed id 19363524)1, 9 Kang J....Lobie P.E. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9048 HGNC: 727 AceView: ARTN Ensembl:ENSG00000117407 euGenes: HUgn9048
    ECgene: ARTN H-InvDB: ARTN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARTN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARTN gene:
    Search GeneIP for patents involving ARTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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