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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARTN Gene

protein-coding   GIFtS: 60
GCID: GC01P044398

artemin

 Explore 19 diseases affiliated with
ARTN via our new
 Human Malady Compendium 
Biological research products
for ARTN
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Artemin1     Neublastin3
EVN1 2 3     Neurotrophic Factor2
ENOVIN1 2     Enovin3
NBN1 2     Neublastin3

External Ids:    HGNC: 7271   Entrez Gene: 90482   Ensembl: ENSG000001174077   OMIM: 6038865   UniProtKB: Q5T4W73   

Export aliases for ARTN gene to outside databases

Previous GC identifers: GC01P044237 GC01P043399 GC01P043828 GC01P043812 GC01P044068 GC01P044171 GC01P042517


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARTN:
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands
which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having
neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown
in culture to support the survival of a number of peripheral neuron populations and at least one population of
dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the
proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor.
Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7
Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex.
Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of
dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the
formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue

Gene Wiki entry for ARTN (Artemin)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARTN gene promoter:
         Egr-2   MZF-1   AP-4   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARTN promoter sequence
   Search SABiosciences Chromatin IP Primers for ARTN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p33-p32   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p33-p32

ARTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARTN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P044398:  view genomic region     (about GC identifiers)

Start:
44,398,992 bp from pter      End:
44,402,913 bp from pter
Size:
3,922 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7 (See protein sequence)
Recommended Name: Artemin precursor  
Size: 220 amino acids; 22878 Da
Subunit: Homodimer; disulfide-linked. Binds to RET (By similarity)
Subcellular location: Secreted (By similarity)
Developmental stage: Expressed during embryogenesis. High level expression seen in fetal kidney and lung while a low
level expression seen in the fetal brain
4 PDB 3D structures from and Proteopedia for ARTN:
2ASK (3D)        2GH0 (3D)        2GYR (3D)        2GYZ (3D)    
Secondary accessions: D3DPY1 D3DPY3 O95441 O96030 Q6P6A3
Alternative splicing: 3 isoforms:  Q5T4W7-1   Q5T4W7-2   Q5T4W7-3   

Explore the universe of human proteins at neXtProt for ARTN: NX_Q5T4W7

ARTN Protein expression data from MOPED and PaxDb:    About this image 
ARTN Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001129687.1  NP_476431.2  NP_476432.2  

ENSEMBL proteins: 
 ENSP00000361434   ENSP00000434784   ENSP00000435804   ENSP00000436727   ENSP00000436149  
 ENSP00000434071   ENSP00000435140   ENSP00000434856   ENSP00000361429   ENSP00000391998  
 ENSP00000387435  
Reactome Protein details: Q5T4W7
Human Recombinant Protein Products for ARTN: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for ARTN (Artemin)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate (see all 3): ARTN
OriGene Custom Protein Services for ARTN 
GenScript Custom Purified and Recombinant Proteins Services for ARTN
Novus Biologicals ARTN Proteins
Novus Biologicals ARTN Lysates
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for ARTN
Uscn Proteins for ARTN

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IEA--

ARTN for ontologies           About GeneDecksing



ARTN Antibody Products: 
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R&D Systems Antibodies for ARTN (Artemin)
OriGene Antibodies: ARTN
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GenScript Superior Antibodies for ARTN
Novus Biologicals ARTN Antibodies
Abcam antibodies for ARTN 
Uscn Antibodies for ARTN
ThermoFisher Antibodies for ARTN

Assay Products for ARTN: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
R&D Systems ELISAs for ARTN (Artemin)         (see all)
GenScript Custom Assay Services for ARTN
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for ARTN


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARTN for domains           About GeneDecksing

1 InterPro domain/family:
 IPR001839 TGF-b_C

Graphical View of Domain Structure for InterPro Entry Q5T4W7

ProtoNet protein and cluster: Q5T4W7

2 Blocks protein families:
IPB001839 Transforming growth factor beta (TGFb)
IPB002400 Growth factor cystine knot superfamily signature


UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7
Similarity: Belongs to the TGF-beta family. GDNF subfamily


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ARTN_HUMAN, Q5T4W7
Function: Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex.
Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of
dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the
formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding TAS9883723
GO:0005515protein binding ----
GO:0008083growth factor activity IEA--
     
ARTN for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for ARTN:
 Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Artn):
 nervous system  vision/eye 

ARTN for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ARTN 

miRNA
Products:
    
OriGene 3'-UTR Clone (see all 5): ARTN
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARTN
2 QIAGEN miScript miRNA Assays for microRNAs that regulate ARTN:
hsa-miR-3121-3p hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidARTN 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARTN (see all 7)
OriGene shRNA RFP: ARTN
OriGene siRNA: ARTN
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARTN
Sirion Biotech Custom design and validation of potent shRNA sequences against ARTN 

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for ARTN
Sirion Biotech Customized adenovirus for overexpression of ARTN 
Sirion Biotech Customized adenovirus for potent knockdown of ARTN

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARTN (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARTN (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 3): ARTN (NM_057090)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARTN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARTN 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for ARTN
Search LifeMap BioReagents cell lines for ARTN
Sirion Biotech Customized stable knockdown cell line services for ARTN 
Sirion Biotech Customized inducible knockdown cell line services for ARTN
Sirion Biotech Customized stable overexpressing cell line services for ARTN
Sirion Biotech Customized inducible overexpressing cell line services for ARTN

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARTN


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Development EGFR signaling pathway
Development GDNF family signaling0.45
GDNF-Family Ligands and Receptor Interactions0.21
Development_GDNF family signaling0.45
2NCAM signaling for neurite out-growth
NCAM signaling for neurite out-growth1.00
NCAM1 interactions0.62
3Axon guidance
Axon guidance1.00
Developmental Biology0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ARTN
    Development GDNF family signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ARTN
    GDNF-Family Ligands and Receptor Interactions

1 GeneGo (Thomson Reuters) Pathway for ARTN
    Development GDNF family signaling

4        Reactome Pathways for ARTN
    Developmental Biology
NCAM1 interactions
NCAM signaling for neurite out-growth
Axon guidance



ARTN for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARTN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/67 Interacting proteins for ARTN (Q5T4W73 ENSP000003919984) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
InteractantInteraction Details
GeneCardExternal ID(s)
GFRA3O606093, ENSP000002747214I2D: score=2 STRING: ENSP00000274721
GDNFENSP000003171454STRING: ENSP00000317145
GFRA1ENSP000003937254STRING: ENSP00000393725
IRS1ENSP000003048954STRING: ENSP00000304895
NCAM1ENSP000003184724STRING: ENSP00000318472
About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction TAS9883723
GO:0007405neuroblast proliferation TAS9883723
GO:0007411axon guidance TAS--
GO:0007422peripheral nervous system development IEA--
GO:0050930induction of positive chemotaxis IEA--

ARTN for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ARTN for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARTN
4 Novoseek chemical compound relationships for ARTN gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 48.4 4 16734417 (1), 10484767 (1), 11222636 (1), 11544105 (1)
6-hydroxydopamine 30.5 1 11043566 (1)
heparan sulfate 28.2 2 16734417 (1), 16709187 (1)
dopamine 11.8 3 10673327 (1), 12953054 (1)

Search CenterWatch for drugs/clinical trials and news about ARTN 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARTN gene (5 alternative transcripts): 
NM_001136215.1  NM_057090.2  NM_057091.2  NM_003976.3  NM_057160.2  

Unigene Cluster for ARTN:

Artemin
Hs.632404  [show with all ESTs]
Unigene Representative Sequence: NM_057090
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000372359(uc001cks.3) ENST00000477048 ENST00000471394 ENST00000498139(uc001cku.3 uc001ckw.3)
ENST00000491846 ENST00000479128 ENST00000472435 ENST00000474592 ENST00000372354
ENST00000438616 ENST00000414809(uc001ckv.3 uc001ckt.3)

miRNA
Products:
     
OriGene 3'-UTR Clone (see all 5): ARTN
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARTN
2 QIAGEN miScript miRNA Assays for microRNAs that regulate ARTN:
hsa-miR-3121-3p hsa-miR-4267
SwitchGear 3'UTR luciferase reporter plasmidARTN 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARTN (see all 7)
OriGene shRNA RFP: ARTN
OriGene siRNA: ARTN
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARTN
Sirion Biotech Custom design and validation of potent shRNA sequences against ARTN 
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARTN (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARTN (see all 6)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 3): ARTN (NM_057090)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARTN
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARTN 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARTN
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARTN
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARTN
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARTN

Additional cDNA sequence: 

AF109401.1 AF120274.1 BC062375.1 

6 DOTS entries:

DT.101980137  DT.40216700  DT.91699435  DT.95158250  DT.40233398  DT.75101766 

24/38 AceView cDNA sequences (see all 38):

AW137020 BF063378 BC062375 AI935302 AF109401 AW203993 NM_057160 BM981370 
AF120274 NM_003976 BP353368 NM_057090 AI768514 BQ129389 AW206576 AI225050 
AI695822 AW207099 BQ129248 AW293171 AW134909 BF507803 AI424604 AW138964 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ARTN    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1:                          -     -           -         
SP2:                    -     -     -                     
SP3:                                                      
SP4:                                            -         


ECgene alternative splicing isoforms for ARTN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGCTGGCC
ARTN Expression
About this image

ARTN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
BoneMandibular ProcessBone
CartilageLumbar Intervertebral DiscCartilage
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells 
NameCategory
PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

See ARTN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARTN

SOURCE GeneReport for Unigene cluster: Hs.632404

UniProtKB/Swiss-Prot: ARTN_HUMAN, Q5T4W7
Tissue specificity: Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas,
heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain

    SABiosciences Expression via Pathway-Focused PCR Arrays including ARTN: 
          Neurogenesis in human mouse rat
          Growth Factors in human mouse rat
          Neurotrophins & Receptors in human mouse rat

Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARTN
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARTN
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARTN
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARTN
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARTN

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ARTN gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves LOC1008579101 uncharacterized LOC100857910 54.27(n)
46.38(a)
  100857910  XM_003641685.1  XP_003641733.1 
lizard
(Anolis carolinensis)
Reptilia ARTN6
--
48(a)
1 ↔ 1
4(108783127-108783909)
zebrafish
(Danio rerio)
Actinopterygii si:ch1073-141i10.16
si:ch1073-141i10.1
45(a)
1 → many
6(3266343-3266657)


ENSEMBL Gene Tree for ARTN (if available)
TreeFam Gene Tree for ARTN (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ARTN gene
GDNF2  PSPN2  NRTN2  
1 SIMAP similar gene for ARTN using alignment to 5 protein entries:     ARTN_HUMAN (see all proteins):
PSPN

ARTN for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/84 NCBI SNPs in ARTN are shown (see all 84    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1388630281,2
--44397366(+) CCCCAA/GCATCC 3 -- us2k10--------
rs1419940531,2
--44397432(+) AGTGAC/GCTTTC 3 -- us2k10--------
rs1877649731,2
--44397480(+) TGGCCA/GGCTCC 3 -- us2k10--------
rs1508194021,2
--44397702(+) CCTCCA/GTTTCT 3 -- us2k10--------
rs1381222431,2
--44397745(+) CCTGCA/CTGGAT 3 -- us2k10--------
rs1170653651,2
F--44397846(+) GCAGCC/TGGTTG 3 -- us2k11Minor allele frequency- T:0.03EA 120
rs1924798581,2
--44397847(+) CAGCCA/GGTTGT 3 -- us2k10--------
rs1493293741,2
--44397881(+) CCCTGC/TTTGGC 3 -- us2k10--------
rs1166934141,2
--44397932(+) CACCAC/ACTCCA 3 -- us2k11Minor allele frequency- A:0.01NA 120
rs1844769911,2
--44397944(+) CAGCAG/TTTCTC 3 -- us2k10--------

HapMap Linkage Disequilibrium report for ARTN (44398992 - 44402913 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ARTN: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARTN
DNA2.0 Custom Variant and Variant Library Synthesis for ARTN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARTN for disorders           About GeneDecksing

OMIM gene information: 603886    OMIM disorders: --

19 diseases for ARTN:    About MalaCards
neurodegenerative disease    spinal cord injury    burning mouth syndrome    neuronitis
hirschsprung's disease    parkinson's disease    pancreatic cancer    endometrial carcinoma
pancreatitis    esophageal carcinoma    thyroid carcinoma    carcinoma
esophagitis    pancreatic carcinoma    lung carcinoma    neuropathy
thyroiditis    adenocarcinoma    prostatitis

1 disease from the University of Copenhagen DISEASES database for ARTN:
Hirschsprung's disease

6 Novoseek disease relationships for ARTN gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hirschsprung disease 62.3 1 18970938 (1)
neurodegenerative diseases 26.1 3 10583383 (1), 10652334 (1)
parkinson disease 25.1 1 17218019 (1)
pancreatic cancer 12.5 2 16269310 (1), 16858191 (1)
tumors 0 8 20118197 (2), 12679485 (1), 19363524 (1)
cancer 0 5 16858191 (4)

Human Genome Epidemiology (HuGE) Navigator: ARTN (1 document)

Export disorders for ARTN gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ARTN gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with ARTN)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. (PubMed id 9883723)1, 2, 3, 9 Baloh R.H....Milbrandt J. (1998)
  2. Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants. (PubMed id 10583383)1, 2, 9 Masure S.... Gordon R.D. (1999)
  3. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. (PubMed id 16765900)1, 2, 9 Wang X.... Garcia K.C. (2006)
  4. In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. (PubMed id 10673327)1, 2, 9 Rosenblad C....Johansen T.E. (2000)
  5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Artemin is estrogen regulated and mediates antiestrog en resistance in mammary carcinoma. (PubMed id 20305694)1, 9 Kang J....Lobie P.E. (2010)
  8. Artemin stimulates oncogenicity and invasiveness of h uman endometrial carcinoma cells. (PubMed id 20118197)1, 9 Pandey V....Lobie P.E. (2010)
  9. Artemin is oncogenic for human mammary carcinoma cells. (PubMed id 19363524)1, 9 Kang J....Lobie P.E. (2009)
  10. [Artemin and GFRalpha3 expressions and their relevance to perineural invasiveness and metastasis of pancreatic carcinoma.] (PubMed id 19304517)1, 9 Zhu D.L....Gao J.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9048 HGNC: 727 AceView: ARTN Ensembl:ENSG00000117407 euGenes: HUgn9048
ECgene: ARTN H-InvDB: ARTN

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ARTN Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ARTN gene:
Search GeneIP for patents involving ARTN

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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