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Aliases for ART5 Gene

Aliases for ART5 Gene

  • ADP-Ribosyltransferase 5 2 3
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 5 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 5 3 4
  • Mono(ADP-Ribosyl)Transferase 5 3 4
  • EC 2.4.2.31 4 64
  • ARTC5 3 4
  • Ecto-ADP-Ribosyltransferase 5 3

External Ids for ART5 Gene

Summaries for ART5 Gene

Entrez Gene Summary for ART5 Gene

  • The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for ART5 Gene

ART5 (ADP-Ribosyltransferase 5) is a Protein Coding gene. Among its related pathways are Nicotinate and nicotinamide metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. An important paralog of this gene is ART1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART5 Gene

Genomics for ART5 Gene

Genomic Location for ART5 Gene

Start:
3,638,503 bp from pter
End:
3,642,316 bp from pter
Size:
3,814 bases
Orientation:
Minus strand

Genomic View for ART5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ART5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART5 Gene

Regulatory Elements for ART5 Gene

Proteins for ART5 Gene

  • Protein details for ART5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L15-NAR5_HUMAN
    Recommended name:
    Ecto-ADP-ribosyltransferase 5
    Protein Accession:
    Q96L15
    Secondary Accessions:
    • C9IYG7
    • Q6UX84
    • Q86W02

    Protein attributes for ART5 Gene

    Size:
    291 amino acids
    Molecular mass:
    32054 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ART5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ART5 Gene

Proteomics data for ART5 Gene at MOPED

Selected DME Specific Peptides for ART5 Gene

Post-translational modifications for ART5 Gene

  • Glycosylation at Asn101, Asn196, and Asn250

Other Protein References for ART5 Gene

Domains for ART5 Gene

Protein Domains for ART5 Gene

UniProtKB/Swiss-Prot:

NAR5_HUMAN
Family:
  • Belongs to the Arg-specific ADP-ribosyltransferase family.:
    • Q96L15
genes like me logo Genes that share domains with ART5: view

No data available for Gene Families for ART5 Gene

Function for ART5 Gene

Molecular function for ART5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine

Enzyme Numbers (IUBMB) for ART5 Gene

Gene Ontology (GO) - Molecular Function for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0003953 NAD+ nucleosidase activity IEA --
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
genes like me logo Genes that share ontologies with ART5: view

Phenotypes for ART5 Gene

GenomeRNAi human phenotypes for ART5:
genes like me logo Genes that share phenotypes with ART5: view

miRNA for ART5 Gene

miRTarBase miRNAs that target ART5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ART5 Gene

Localization for ART5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ART5 Gene COMPARTMENTS Subcellular localization image for ART5 gene
Compartment Confidence
extracellular 3
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ART5: view

Pathways for ART5 Gene

SuperPathways for ART5 Gene

Superpath Contained pathways
1 Nicotinate and nicotinamide metabolism
genes like me logo Genes that share pathways with ART5: view

Pathways by source for ART5 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ART5 Gene

Interacting Proteins for ART5 Gene

Gene Ontology (GO) - Biological Process for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA --
genes like me logo Genes that share ontologies with ART5: view

Compounds for ART5 Gene

(5) HMDB Compounds for ART5 Gene

Compound Synonyms Cas Number PubMed IDs
L-Arginine
  • (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate
74-79-3
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
Niacinamide
  • 3-Carbamoylpyridine
98-92-0
genes like me logo Genes that share compounds with ART5: view

Transcripts for ART5 Gene

Unigene Clusters for ART5 Gene

ADP-ribosyltransferase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ART5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2: -

Relevant External Links for ART5 Gene

GeneLoc Exon Structure for
ART5
ECgene alternative splicing isoforms for
ART5

Expression for ART5 Gene

mRNA expression in normal human tissues for ART5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART5 Gene

This gene is overexpressed in Testis (20.2) and Muscle - Skeletal (5.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ART5 Gene

SOURCE GeneReport for Unigene cluster for ART5 Gene Hs.125680

genes like me logo Genes that share expressions with ART5: view

Orthologs for ART5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ART5 36
  • 99.43 (n)
  • 98.97 (a)
ART5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 63 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
ART5 36
  • 79.23 (n)
  • 71.04 (a)
dog
(Canis familiaris)
Mammalia ART5 36
  • 89.4 (n)
  • 90.04 (a)
ART5 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Art5 36
  • 84.19 (n)
  • 83.82 (a)
Art5 16
Art5 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 51 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ART5 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Art5 36
  • 83.46 (n)
  • 82.72 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 31 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490227 36
  • 51.05 (n)
  • 42.62 (a)
zebrafish
(Danio rerio)
Actinopterygii art4 37
  • 29 (a)
ManyToMany
BX908804.1 37
  • 28 (a)
ManyToMany
CABZ01019904.1 37
  • 28 (a)
ManyToMany
CABZ01019905.1 37
  • 36 (a)
ManyToMany
CABZ01019905.2 37
  • 34 (a)
ManyToMany
CABZ01064699.1 37
  • 30 (a)
ManyToMany
CR846080.3 37
  • 34 (a)
ManyToMany
CR846080.4 37
  • 27 (a)
ManyToMany
CR846080.5 37
  • 35 (a)
ManyToMany
si:ch211-163m16.7 37
  • 25 (a)
ManyToMany
si:ch211-51i16.1 37
  • 28 (a)
ManyToMany
si:ch211-51i16.3 37
  • 32 (a)
ManyToMany
si:ch73-379f5.5 37
  • 30 (a)
ManyToMany
Species with no ortholog for ART5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART5 Gene

ENSEMBL:
Gene Tree for ART5 (if available)
TreeFam:
Gene Tree for ART5 (if available)

Paralogs for ART5 Gene

Paralogs for ART5 Gene

Selected SIMAP similar genes for ART5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ART5 Gene

genes like me logo Genes that share paralogs with ART5: view

Variants for ART5 Gene

Sequence variations from dbSNP and Humsavar for ART5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs908161 -- 3,641,245(+) CAAGC(A/G)CTTTT intron-variant
rs908162 -- 3,641,252(+) TTTTC(C/T)GGCTG intron-variant
rs932097 -- 3,641,781(+) TTGGG(A/G)CTAGG intron-variant
rs1567921 -- 3,642,179(+) CCACT(C/T)GAAGG utr-variant-5-prime, nc-transcript-variant, upstream-variant-2KB
rs1996208 -- 3,639,065(+) CTCCG(C/T)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ART5 Gene

Variant ID Type Subtype PubMed ID
dgv336e1 CNV Complex 17122850
esv28322 CNV Gain+Loss 19812545
nsv832051 CNV Gain 17160897
essv2992 CNV CNV 17122850
nsv467660 CNV Gain 19166990
dgv337e1 CNV Complex 17122850
nsv428247 CNV Loss 18775914
nsv832052 CNV Loss 17160897
nsv526441 CNV Gain 19592680
esv2658889 CNV Deletion 23128226
nsv509385 CNV Insertion 20534489
nsv8775 CNV Loss 18304495

Relevant External Links for ART5 Gene

HapMap Linkage Disequilibrium report
ART5

Disorders for ART5 Gene

No disorders were found for ART5 Gene.

No data available for UniProtKB/Swiss-Prot for ART5 Gene

Publications for ART5 Gene

  1. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. (PMID: 11587854) Glowacki G. … Koch-Nolte F. (Gene 2001) 2 3 23
  2. Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. (PMID: 10448534) Okazaki I.J. … Moss J. (Annu. Rev. Nutr. 1999) 2 3
  3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G. … Koch-Nolte F. (Protein Sci. 2002) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ART5 Gene

Sources for ART5 Gene

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