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Aliases for ART5 Gene

Aliases for ART5 Gene

  • ADP-Ribosyltransferase 5 2 3
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 5 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 5 3 4
  • Mono(ADP-Ribosyl)Transferase 5 3 4
  • EC 4 63
  • ARTC5 3 4
  • Ecto-ADP-Ribosyltransferase 5 3

External Ids for ART5 Gene

Previous GeneCards Identifiers for ART5 Gene

  • GC11M004234
  • GC11M003929
  • GC11M003621
  • GC11M003624
  • GC11M003616
  • GC11M003659
  • GC11M003397

Summaries for ART5 Gene

Entrez Gene Summary for ART5 Gene

  • The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for ART5 Gene

ART5 (ADP-Ribosyltransferase 5) is a Protein Coding gene. Among its related pathways are Nicotinate and nicotinamide metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. An important paralog of this gene is ART1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART5 Gene

Genomics for ART5 Gene

Regulatory Elements for ART5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ART5 Gene

3,638,503 bp from pter
3,642,316 bp from pter
3,814 bases
Minus strand

Genomic View for ART5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ART5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART5 Gene

Proteins for ART5 Gene

  • Protein details for ART5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ecto-ADP-ribosyltransferase 5
    Protein Accession:
    Secondary Accessions:
    • C9IYG7
    • Q6UX84
    • Q86W02

    Protein attributes for ART5 Gene

    291 amino acids
    Molecular mass:
    32054 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ART5 Gene


neXtProt entry for ART5 Gene

Proteomics data for ART5 Gene at MOPED

Selected DME Specific Peptides for ART5 Gene

Post-translational modifications for ART5 Gene

  • Glycosylation at Asn101, Asn196, and Asn250

Other Protein References for ART5 Gene

Antibody Products

Domains for ART5 Gene

Protein Domains for ART5 Gene

Suggested Antigen Peptide Sequences for ART5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Arg-specific ADP-ribosyltransferase family.
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART5: view

No data available for Gene Families for ART5 Gene

Function for ART5 Gene

Molecular function for ART5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine

Enzyme Numbers (IUBMB) for ART5 Gene

Gene Ontology (GO) - Molecular Function for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0003953 NAD+ nucleosidase activity IEA --
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
genes like me logo Genes that share ontologies with ART5: view

Phenotypes for ART5 Gene

GenomeRNAi human phenotypes for ART5:
genes like me logo Genes that share phenotypes with ART5: view

Animal Model Products

miRNA for ART5 Gene

miRTarBase miRNAs that target ART5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ART5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ART5 Gene

Localization for ART5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART5 Gene


Subcellular locations from

Jensen Localization Image for ART5 Gene COMPARTMENTS Subcellular localization image for ART5 gene
Compartment Confidence
extracellular 3
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ART5: view

Pathways for ART5 Gene

SuperPathways for ART5 Gene

Superpath Contained pathways
1 Nicotinate and nicotinamide metabolism
genes like me logo Genes that share pathways with ART5: view

Pathways by source for ART5 Gene

1 GeneGo (Thomson Reuters) pathway for ART5 Gene

Interacting Proteins for ART5 Gene

Gene Ontology (GO) - Biological Process for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA --
genes like me logo Genes that share ontologies with ART5: view

Drugs for ART5 Gene

(5) HMDB Compounds for ART5 Gene

Compound Synonyms Cas Number PubMed IDs
  • (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoate
  • 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate inner salt
  • 1,4-Dihydronicotinamide adenine dinucleotide
  • Adenine-nicotinamide dinucleotide phosphate
  • 3-Carbamoylpyridine
genes like me logo Genes that share compounds with ART5: view

Transcripts for ART5 Gene

Unigene Clusters for ART5 Gene

ADP-ribosyltransferase 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ART5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ART5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP2: -

Relevant External Links for ART5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ART5 Gene

mRNA expression in normal human tissues for ART5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART5 Gene

This gene is overexpressed in Testis (20.2) and Muscle - Skeletal (5.6).

Protein differential expression in normal tissues for ART5 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ART5 Gene

SOURCE GeneReport for Unigene cluster for ART5 Gene Hs.125680

genes like me logo Genes that share expressions with ART5: view

Expression partners for ART5 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ART5 Gene

Orthologs for ART5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ART5 35
  • 79.23 (n)
  • 71.04 (a)
-- 36
  • 63 (a)
-- 36
  • 67 (a)
-- 36
  • 68 (a)
(Canis familiaris)
Mammalia ART5 35
  • 89.4 (n)
  • 90.04 (a)
ART5 36
  • 81 (a)
(Mus musculus)
Mammalia Art5 35
  • 84.19 (n)
  • 83.82 (a)
Art5 16
Art5 36
  • 75 (a)
(Pan troglodytes)
Mammalia ART5 35
  • 99.43 (n)
  • 98.97 (a)
ART5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Art5 35
  • 83.46 (n)
  • 82.72 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
-- 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia ART5 36
  • 56 (a)
(Gallus gallus)
Aves -- 36
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
-- 36
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490227 35
  • 51.05 (n)
  • 42.62 (a)
(Danio rerio)
Actinopterygii art4 36
  • 29 (a)
BX908804.1 36
  • 28 (a)
CABZ01019904.1 36
  • 28 (a)
CABZ01019905.1 36
  • 36 (a)
CABZ01019905.2 36
  • 34 (a)
CABZ01064699.1 36
  • 30 (a)
CR846080.3 36
  • 34 (a)
CR846080.4 36
  • 27 (a)
CR846080.5 36
  • 35 (a)
si:ch211-163m16.7 36
  • 25 (a)
si:ch211-51i16.1 36
  • 28 (a)
si:ch211-51i16.3 36
  • 32 (a)
si:ch73-379f5.5 36
  • 30 (a)
Species with no ortholog for ART5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART5 Gene

Gene Tree for ART5 (if available)
Gene Tree for ART5 (if available)

Paralogs for ART5 Gene

Paralogs for ART5 Gene

(4) SIMAP similar genes for ART5 Gene using alignment to 3 proteins: Pseudogenes for ART5 Gene

genes like me logo Genes that share paralogs with ART5: view

Variants for ART5 Gene

Sequence variations from dbSNP and Humsavar for ART5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs908161 -- 3,641,245(+) CAAGC(A/G)CTTTT intron-variant
rs908162 -- 3,641,252(+) TTTTC(C/T)GGCTG intron-variant
rs932097 -- 3,641,781(+) TTGGG(A/G)CTAGG intron-variant
rs1567921 -- 3,642,179(+) CCACT(C/T)GAAGG utr-variant-5-prime, nc-transcript-variant, upstream-variant-2KB
rs1996208 -- 3,639,065(+) CTCCG(C/T)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ART5 Gene

Variant ID Type Subtype PubMed ID
dgv336e1 CNV Complex 17122850
esv28322 CNV Gain+Loss 19812545
nsv832051 CNV Gain 17160897
essv2992 CNV CNV 17122850
nsv467660 CNV Gain 19166990
dgv337e1 CNV Complex 17122850
nsv428247 CNV Loss 18775914
nsv832052 CNV Loss 17160897
nsv526441 CNV Gain 19592680
esv2658889 CNV Deletion 23128226
nsv509385 CNV Insertion 20534489
nsv8775 CNV Loss 18304495

Relevant External Links for ART5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART5 Gene

Disorders for ART5 Gene

No disorders were found for ART5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ART5 Gene

Publications for ART5 Gene

  1. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. (PMID: 11587854) Glowacki G. … Koch-Nolte F. (Gene 2001) 2 3 23
  2. Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. (PMID: 10448534) Okazaki I.J. … Moss J. (Annu. Rev. Nutr. 1999) 2 3
  3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G. … Koch-Nolte F. (Protein Sci. 2002) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ART5 Gene

Sources for ART5 Gene

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