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Aliases for ART5 Gene

Aliases for ART5 Gene

  • ADP-Ribosyltransferase 5 2 3 5
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 5 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 5 3 4
  • Mono(ADP-Ribosyl)Transferase 5 3 4
  • EC 2.4.2.31 4 58
  • ARTC5 3 4
  • Ecto-ADP-Ribosyltransferase 5 3

External Ids for ART5 Gene

Previous GeneCards Identifiers for ART5 Gene

  • GC11M004234
  • GC11M003929
  • GC11M003621
  • GC11M003624
  • GC11M003616
  • GC11M003659
  • GC11M003397

Summaries for ART5 Gene

Entrez Gene Summary for ART5 Gene

  • The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for ART5 Gene

ART5 (ADP-Ribosyltransferase 5) is a Protein Coding gene. Among its related pathways are NAD metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. An important paralog of this gene is ART1.

Additional gene information for ART5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART5 Gene

Genomics for ART5 Gene

Regulatory Elements for ART5 Gene

Enhancers for ART5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H003641 1 ENCODE 38 -0.2 -189 1.9 FOXA2 ARID4B TCF12 GLIS2 KLF7 ATF7 SP3 SP5 KAT8 MEF2D ART5 GC11M003663 ENSG00000201279
GH11H003830 1.8 FANTOM5 ENCODE dbSUPER 9.7 -194.0 -193993 12.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 ZNF143 RHOG NUP98 RRM1 ENSG00000206976 ART1 ART5 CHRNA10 STIM1 PPIAP40 ENSG00000236710
GH11H003614 1.3 FANTOM5 Ensembl ENCODE 12.2 +27.4 27409 1.7 BCOR HDAC1 PKNOX1 ZMYM3 MAX ZIC2 RELA GATA3 CTBP1 GATA2 ART1 ART5 LOC101927708 NUP98 RHOG TRPC2
GH11H003783 1.4 Ensembl ENCODE dbSUPER 8.4 -143.7 -143678 4.4 HDGF PKNOX1 ATF1 BMI1 BATF ZNF143 ATF7 RUNX3 CREM IKZF2 ART5 GC11P003781 GC11P003794
GH11H003824 1.2 ENCODE dbSUPER 9.8 -183.8 -183840 3.2 HDAC1 HNRNPUL1 ATF1 RB1 ARNT ARID4B RAD21 ZNF766 CBX5 GATA2 NUP98 OSBPL5 RRM1 ART1 ART5 CHRNA10 GC11P003826 GC11P003814
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ART5 on UCSC Golden Path with GeneCards custom track

Promoters for ART5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036097 116 801 ARID4B GLIS2 ATF7 SP3 SP5 KAT8 ATF4 ZNF610 SMARCA4 GLIS1

Genomic Locations for ART5 Gene

Genomic Locations for ART5 Gene
chr11:3,638,503-3,642,316
(GRCh38/hg38)
Size:
3,814 bases
Orientation:
Minus strand
chr11:3,659,733-3,663,546
(GRCh37/hg19)

Genomic View for ART5 Gene

Genes around ART5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ART5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ART5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART5 Gene

Proteins for ART5 Gene

  • Protein details for ART5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L15-NAR5_HUMAN
    Recommended name:
    Ecto-ADP-ribosyltransferase 5
    Protein Accession:
    Q96L15
    Secondary Accessions:
    • C9IYG7
    • Q6UX84
    • Q86W02

    Protein attributes for ART5 Gene

    Size:
    291 amino acids
    Molecular mass:
    32054 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ART5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ART5 Gene

Selected DME Specific Peptides for ART5 Gene

Q96L15:
  • EEMEEKA
  • CSHFNCAYLG

Post-translational modifications for ART5 Gene

  • Glycosylation at posLast=101101, Asn196, and posLast=250250
  • Modification sites at PhosphoSitePlus

Domains & Families for ART5 Gene

Gene Families for ART5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ART5 Gene

Suggested Antigen Peptide Sequences for ART5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96L15

UniProtKB/Swiss-Prot:

NAR5_HUMAN :
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
Family:
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART5: view

Function for ART5 Gene

Molecular function for ART5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Enzyme Numbers (IUBMB) for ART5 Gene

Gene Ontology (GO) - Molecular Function for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0003953 NAD+ nucleosidase activity IEA --
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ART5: view
genes like me logo Genes that share phenotypes with ART5: view

Animal Model Products

CRISPR Products

miRNA for ART5 Gene

miRTarBase miRNAs that target ART5

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ART5 Gene

Localization for ART5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ART5 gene
Compartment Confidence
extracellular 4
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ART5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ART5 Gene

Pathways & Interactions for ART5 Gene

SuperPathway Contained pathways
1 NAD metabolism
genes like me logo Genes that share pathways with ART5: view

Pathways by source for ART5 Gene

1 GeneGo (Thomson Reuters) pathway for ART5 Gene

Interacting Proteins for ART5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352992%0d%0a9606.ENSP00000264606%0d%0a
Selected Interacting proteins: Q96L15-NAR5_HUMAN ENSP00000352992 for ART5 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA --
genes like me logo Genes that share ontologies with ART5: view

No data available for SIGNOR curated interactions for ART5 Gene

Drugs & Compounds for ART5 Gene

(4) Drugs for ART5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist 0
Nicotinamide Approved Nutra 937,941
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(1) Additional Compounds for ART5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with ART5: view

Transcripts for ART5 Gene

Unigene Clusters for ART5 Gene

ADP-ribosyltransferase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ART5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2: -

Relevant External Links for ART5 Gene

GeneLoc Exon Structure for
ART5
ECgene alternative splicing isoforms for
ART5

Expression for ART5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ART5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART5 Gene

This gene is overexpressed in Testis (x20.2) and Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for ART5 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ART5 Gene



Protein tissue co-expression partners for ART5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ART5 Gene:

ART5

SOURCE GeneReport for Unigene cluster for ART5 Gene:

Hs.125680

Evidence on tissue expression from TISSUES for ART5 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ART5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ART5 Gene

Orthologs for ART5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ART5 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia ART5 33 34
  • 89.4 (n)
mouse
(Mus musculus)
Mammalia Art5 33 16 34
  • 84.19 (n)
rat
(Rattus norvegicus)
Mammalia Art5 33
  • 83.46 (n)
cow
(Bos Taurus)
Mammalia ART5 33
  • 79.23 (n)
-- 34
  • 68 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
-- 34
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ART5 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490227 33
  • 51.05 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01019905.1 34
  • 36 (a)
ManyToMany
CR846080.5 34
  • 35 (a)
ManyToMany
CABZ01019905.2 34
  • 34 (a)
ManyToMany
CR846080.3 34
  • 34 (a)
ManyToMany
si:ch211-51i16.3 34
  • 32 (a)
ManyToMany
CABZ01064699.1 34
  • 30 (a)
ManyToMany
si:ch73-379f5.5 34
  • 30 (a)
ManyToMany
art4 34
  • 29 (a)
ManyToMany
BX908804.1 34
  • 28 (a)
ManyToMany
CABZ01019904.1 34
  • 28 (a)
ManyToMany
si:ch211-51i16.1 34
  • 28 (a)
ManyToMany
CR846080.4 34
  • 27 (a)
ManyToMany
si:ch211-163m16.7 34
  • 25 (a)
ManyToMany
Species where no ortholog for ART5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART5 Gene

ENSEMBL:
Gene Tree for ART5 (if available)
TreeFam:
Gene Tree for ART5 (if available)

Paralogs for ART5 Gene

Paralogs for ART5 Gene

(4) SIMAP similar genes for ART5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ART5 Gene

genes like me logo Genes that share paralogs with ART5: view

Variants for ART5 Gene

Sequence variations from dbSNP and Humsavar for ART5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000176092 -- 3,640,829(+) CTCTG(C/T)CTCCC intron-variant
rs1000611646 -- 3,641,035(+) ACCGC(A/G)CGCAG intron-variant
rs1001035551 -- 3,638,999(+) GCAAC(C/T)CACCT intron-variant
rs1001514578 -- 3,643,931(+) CTGTA(A/T)TCCCA upstream-variant-2KB
rs1001559551 -- 3,643,645(+) CTACC(A/G)TTTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ART5 Gene

Variant ID Type Subtype PubMed ID
nsv8775 CNV loss 18304495
nsv832052 CNV loss 17160897
nsv832051 CNV gain 17160897
nsv553140 CNV gain 21841781
nsv526441 CNV gain 19592680
nsv509385 CNV insertion 20534489
nsv467660 CNV gain 19166990
nsv428247 CNV loss 18775914
nsv1046356 CNV gain 25217958
esv3625152 CNV loss 21293372
esv3625148 CNV gain 21293372
esv3625147 CNV gain 21293372
esv28322 CNV gain+loss 19812545
esv2760300 CNV gain 21179565
esv2760179 CNV loss 21179565
esv2759796 CNV gain+loss 17122850
esv2658889 CNV deletion 23128226

Variation tolerance for ART5 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ART5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ART5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART5 Gene

Disorders for ART5 Gene

Relevant External Links for ART5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ART5

No disorders were found for ART5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ART5 Gene

Publications for ART5 Gene

  1. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. (PMID: 11587854) Glowacki G … Koch-Nolte F (Gene 2001) 2 3 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G … Koch-Nolte F (Protein science : a publication of the Protein Society 2002) 3 4 60
  5. Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. (PMID: 10448534) Okazaki IJ … Moss J (Annual review of nutrition 1999) 2 3 60

Products for ART5 Gene

Sources for ART5 Gene

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