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Aliases for ART5 Gene

Aliases for ART5 Gene

  • ADP-Ribosyltransferase 5 2 3 5
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 5 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 5 3 4
  • Mono(ADP-Ribosyl)Transferase 5 3 4
  • EC 2.4.2.31 4 61
  • ARTC5 3 4
  • Ecto-ADP-Ribosyltransferase 5 3

External Ids for ART5 Gene

Previous GeneCards Identifiers for ART5 Gene

  • GC11M004234
  • GC11M003929
  • GC11M003621
  • GC11M003624
  • GC11M003616
  • GC11M003659
  • GC11M003397

Summaries for ART5 Gene

Entrez Gene Summary for ART5 Gene

  • The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for ART5 Gene

ART5 (ADP-Ribosyltransferase 5) is a Protein Coding gene. Among its related pathways are NAD metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. An important paralog of this gene is ART1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART5 Gene

Genomics for ART5 Gene

Regulatory Elements for ART5 Gene

Enhancers for ART5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G003641 1 ENCODE 38 -0.2 -189 1.9 FOXA2 CREB3L1 ARID4B E2F7 ZNF48 TCF12 GLIS2 GATA2 KLF7 SP3 ART5 ENSG00000201279 GC11M003663
GH11G003830 1.8 FANTOM5 ENCODE dbSUPER 9.7 -194.0 -193993 12.5 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC MEF2D RHOG NUP98 RRM1 ENSG00000206976 ART1 ART5 CHRNA10 STIM1 ENSG00000230593 ENSG00000236710
GH11G003614 1.3 FANTOM5 Ensembl ENCODE 12.3 +27.4 27409 1.7 BCOR HDAC1 PKNOX1 ZMYM3 MAX ZIC2 RELA GATA3 GATA2 HES1 ART1 ART5 LOC101927708 NUP98 RHOG TRPC2
GH11G003783 1.5 Ensembl ENCODE dbSUPER 8.4 -143.7 -143678 4.4 HDGF PKNOX1 ATF1 ARNT CREB3L1 ARID4B SIN3A ZNF48 YY1 GLIS2 ART5 GC11P003781 GC11P003794
GH11G003824 1.2 ENCODE dbSUPER 9.7 -183.8 -183840 3.2 HDGF HNRNPUL1 ATF1 CREB3L1 ARNT AGO1 ARID4B ZNF766 CBX5 GATA2 NUP98 ART1 ART5 CHRNA10 GC11P003826 GC11P003814
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ART5 on UCSC Golden Path with GeneCards custom track

Promoters for ART5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036097 116 801 CREB3L1 ARID4B ZNF48 GLIS2 GATA2 SP3 SP5 JUNB KAT8 ATF4

Genomic Location for ART5 Gene

Chromosome:
11
Start:
3,638,503 bp from pter
End:
3,642,316 bp from pter
Size:
3,814 bases
Orientation:
Minus strand

Genomic View for ART5 Gene

Genes around ART5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ART5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ART5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART5 Gene

Proteins for ART5 Gene

  • Protein details for ART5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L15-NAR5_HUMAN
    Recommended name:
    Ecto-ADP-ribosyltransferase 5
    Protein Accession:
    Q96L15
    Secondary Accessions:
    • C9IYG7
    • Q6UX84
    • Q86W02

    Protein attributes for ART5 Gene

    Size:
    291 amino acids
    Molecular mass:
    32054 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ART5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ART5 Gene

Selected DME Specific Peptides for ART5 Gene

Q96L15:
  • EEMEEKA
  • CSHFNCAYLG

Post-translational modifications for ART5 Gene

  • Glycosylation at posLast=101101, posLast=196196, and posLast=250250
  • Modification sites at PhosphoSitePlus

Domains & Families for ART5 Gene

Protein Domains for ART5 Gene

Suggested Antigen Peptide Sequences for ART5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96L15

UniProtKB/Swiss-Prot:

NAR5_HUMAN :
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
Family:
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART5: view

No data available for Gene Families for ART5 Gene

Function for ART5 Gene

Molecular function for ART5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Enzyme Numbers (IUBMB) for ART5 Gene

Gene Ontology (GO) - Molecular Function for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0003953 NAD+ nucleosidase activity IEA --
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ART5: view
genes like me logo Genes that share phenotypes with ART5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ART5

CRISPR Products

miRNA for ART5 Gene

miRTarBase miRNAs that target ART5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ART5 Gene

Localization for ART5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ART5 gene
Compartment Confidence
extracellular 4
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ART5: view

Pathways & Interactions for ART5 Gene

SuperPathway Contained pathways
1 NAD metabolism
genes like me logo Genes that share pathways with ART5: view

Pathways by source for ART5 Gene

1 GeneGo (Thomson Reuters) pathway for ART5 Gene

Interacting Proteins for ART5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352992%0d%0a9606.ENSP00000264606%0d%0a
Selected Interacting proteins: ENSP00000352992 Q96L15-NAR5_HUMAN for ART5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ART5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA --
genes like me logo Genes that share ontologies with ART5: view

No data available for SIGNOR curated interactions for ART5 Gene

Drugs & Compounds for ART5 Gene

(4) Drugs for ART5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist 0
Nicotinamide Approved Nutra 919,923
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(1) Additional Compounds for ART5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with ART5: view

Transcripts for ART5 Gene

Unigene Clusters for ART5 Gene

ADP-ribosyltransferase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ART5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2: -

Relevant External Links for ART5 Gene

GeneLoc Exon Structure for
ART5
ECgene alternative splicing isoforms for
ART5

Expression for ART5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ART5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART5 Gene

This gene is overexpressed in Testis (x20.2) and Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for ART5 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ART5 Gene



Protein tissue co-expression partners for ART5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ART5 Gene:

ART5

SOURCE GeneReport for Unigene cluster for ART5 Gene:

Hs.125680

Evidence on tissue expression from TISSUES for ART5 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ART5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ART5 Gene

Orthologs for ART5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ART5 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia ART5 34 35
  • 89.4 (n)
mouse
(Mus musculus)
Mammalia Art5 34 16 35
  • 84.19 (n)
rat
(Rattus norvegicus)
Mammalia Art5 34
  • 83.46 (n)
cow
(Bos Taurus)
Mammalia ART5 34
  • 79.23 (n)
-- 35
  • 68 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 61 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ART5 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 30 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490227 34
  • 51.05 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01019905.1 35
  • 36 (a)
ManyToMany
CR846080.5 35
  • 35 (a)
ManyToMany
CABZ01019905.2 35
  • 34 (a)
ManyToMany
CR846080.3 35
  • 34 (a)
ManyToMany
si:ch211-51i16.3 35
  • 32 (a)
ManyToMany
CABZ01064699.1 35
  • 30 (a)
ManyToMany
si:ch73-379f5.5 35
  • 30 (a)
ManyToMany
art4 35
  • 29 (a)
ManyToMany
BX908804.1 35
  • 28 (a)
ManyToMany
CABZ01019904.1 35
  • 28 (a)
ManyToMany
si:ch211-51i16.1 35
  • 28 (a)
ManyToMany
CR846080.4 35
  • 27 (a)
ManyToMany
si:ch211-163m16.7 35
  • 25 (a)
ManyToMany
Species where no ortholog for ART5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART5 Gene

ENSEMBL:
Gene Tree for ART5 (if available)
TreeFam:
Gene Tree for ART5 (if available)

Paralogs for ART5 Gene

Paralogs for ART5 Gene

(4) SIMAP similar genes for ART5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ART5 Gene

genes like me logo Genes that share paralogs with ART5: view

Variants for ART5 Gene

Sequence variations from dbSNP and Humsavar for ART5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000176092 -- 3,640,829(+) CTCTG(C/T)CTCCC intron-variant
rs1000611646 -- 3,641,035(+) ACCGC(A/G)CGCAG intron-variant
rs1001035551 -- 3,638,999(+) GCAAC(C/T)CACCT intron-variant
rs1001514578 -- 3,643,931(+) CTGTA(A/T)TCCCA upstream-variant-2KB
rs1001559551 -- 3,643,645(+) CTACC(A/G)TTTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ART5 Gene

Variant ID Type Subtype PubMed ID
esv2658889 CNV deletion 23128226
esv2759796 CNV gain+loss 17122850
esv2760179 CNV loss 21179565
esv2760300 CNV gain 21179565
esv28322 CNV gain+loss 19812545
esv3625147 CNV gain 21293372
esv3625148 CNV gain 21293372
esv3625152 CNV loss 21293372
nsv1046356 CNV gain 25217958
nsv428247 CNV loss 18775914
nsv467660 CNV gain 19166990
nsv509385 CNV insertion 20534489
nsv526441 CNV gain 19592680
nsv553140 CNV gain 21841781
nsv832051 CNV gain 17160897
nsv832052 CNV loss 17160897
nsv8775 CNV loss 18304495

Variation tolerance for ART5 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ART5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ART5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART5 Gene

Disorders for ART5 Gene

Relevant External Links for ART5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ART5

No disorders were found for ART5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ART5 Gene

Publications for ART5 Gene

  1. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. (PMID: 11587854) Glowacki G. … Koch-Nolte F. (Gene 2001) 2 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. (PMID: 12070318) Glowacki G. … Koch-Nolte F. (Protein Sci. 2002) 3 4 64
  5. Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. (PMID: 10448534) Okazaki I.J. … Moss J. (Annu. Rev. Nutr. 1999) 2 3 64

Products for ART5 Gene

Sources for ART5 Gene

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