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Aliases for ART4 Gene

Aliases for ART4 Gene

  • ADP-Ribosyltransferase 4 (Dombrock Blood Group) 2 3 5
  • NAD(+)--Protein-Arginine ADP-Ribosyltransferase 4 2 3
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 4 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 4 3 4
  • ADP-Ribosyltransferase 4 (DO Blood Group) 2 3
  • Dombrock Blood Group Carrier Molecule 3 4
  • ARTC4 3 4
  • DOK1 3 4
  • DO 3 4
  • Mono(ADP-Ribosyl)Transferase 4 4
  • Ecto-ADP-Ribosyltransferase 4 3
  • Mono-ADP-Ribosyltransferase 4 3
  • ADP-Ribosyltransferase 4 2
  • Dombrock Blood Group 2
  • CD297 Antigen 4
  • EC 2.4.2.31 4
  • CD297 3

External Ids for ART4 Gene

Previous HGNC Symbols for ART4 Gene

  • DO

Previous GeneCards Identifiers for ART4 Gene

  • GC12M014874
  • GC12M014982
  • GC12M014751

Summaries for ART4 Gene

Entrez Gene Summary for ART4 Gene

  • This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ART4 Gene

ART4 (ADP-Ribosyltransferase 4 (Dombrock Blood Group)) is a Protein Coding gene. Diseases associated with ART4 include Arts Syndrome. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Metabolism of proteins. GO annotations related to this gene include NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART1.

Gene Wiki entry for ART4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART4 Gene

Genomics for ART4 Gene

Regulatory Elements for ART4 Gene

Enhancers for ART4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G014945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -111.8 -111819 19.1 HDGF PKNOX1 ATF1 FOXA2 WRNIP1 SIN3A YBX1 YY1 ZNF766 GATA2 ARHGDIB ERP27 PDE6H WBP11 ART4 H2AFJ HIST4H4 SMCO3 C12orf60 ENSG00000256339
GH12G014980 1.1 Ensembl ENCODE dbSUPER 11.2 -139.0 -138992 3.4 MTA2 IKZF1 MAX RELB IKZF2 MYC RELA ART4 ENSG00000256339 ERP27 WBP11 C12orf60 HIST4H4 H2AFJ SMCO3 ARHGDIB PDE6H
GH12G014883 1 Ensembl ENCODE 11.5 -41.5 -41477 3.2 PKNOX1 NFIB CTBP1 GATA3 GATA2 CBX5 POLR2A RCOR1 IKZF2 MTA2 ENSG00000256339 ERP27 PDE6H ART4 SMCO3 ARHGDIB HIST4H4 H2AFJ WBP11 C12orf60
GH12G014896 1 Ensembl ENCODE 11.4 -53.2 -53218 1.3 TAL1 FOSL1 TCF12 ZNF316 GATA2 NCOR1 FOS NFE2 TRIM24 CEBPB ERP27 ART4 SMCO3 ENSG00000256339 PDE6H GC12M014889 GC12M014903
GH12G014892 0.7 Ensembl ENCODE 12.2 -49.9 -49936 1.9 CTCF RAD21 ERP27 ART4 ENSG00000256339 SMCO3 GC12M014889 GC12M014903
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ART4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ART4 Gene

Chromosome:
12
Start:
14,825,569 bp from pter
End:
14,843,495 bp from pter
Size:
17,927 bases
Orientation:
Minus strand

Genomic View for ART4 Gene

Genes around ART4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ART4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ART4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART4 Gene

Proteins for ART4 Gene

  • Protein details for ART4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93070-NAR4_HUMAN
    Recommended name:
    Ecto-ADP-ribosyltransferase 4
    Protein Accession:
    Q93070
    Secondary Accessions:
    • Q9BZ50
    • Q9BZ51
    • Q9HB06

    Protein attributes for ART4 Gene

    Size:
    314 amino acids
    Molecular mass:
    35878 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ART4 Gene

Post-translational modifications for ART4 Gene

  • Glycosylation at posLast=114114, posLast=178178, posLast=222222, Asn257, and posLast=274274
  • Modification sites at PhosphoSitePlus

Other Protein References for ART4 Gene

No data available for DME Specific Peptides for ART4 Gene

Domains & Families for ART4 Gene

Gene Families for ART4 Gene

Protein Domains for ART4 Gene

Graphical View of Domain Structure for InterPro Entry

Q93070

UniProtKB/Swiss-Prot:

NAR4_HUMAN :
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
Family:
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART4: view

Function for ART4 Gene

Molecular function for ART4 Gene

GENATLAS Biochemistry:
ADP-ribosyltransferase 4,expressed in testis
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Enzyme Numbers (IUBMB) for ART4 Gene

Gene Ontology (GO) - Molecular Function for ART4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity NAS 9119374
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ART4: view
genes like me logo Genes that share phenotypes with ART4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ART4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ART4 Gene

Localization for ART4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART4 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ART4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ART4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane NAS 9119374
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ART4: view

Pathways & Interactions for ART4 Gene

genes like me logo Genes that share pathways with ART4: view

Pathways by source for ART4 Gene

Interacting Proteins for ART4 Gene

Selected Interacting proteins: Q93070-NAR4_HUMAN for ART4 Gene via IID

Gene Ontology (GO) - Biological Process for ART4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation NAS,IEA 9119374
GO:0006501 C-terminal protein lipidation TAS --
GO:0006525 arginine metabolic process NAS 11001920
genes like me logo Genes that share ontologies with ART4: view

No data available for SIGNOR curated interactions for ART4 Gene

Drugs & Compounds for ART4 Gene

(4) Drugs for ART4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist 0
Nicotinamide Approved Nutra 919,923
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(1) Additional Compounds for ART4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
genes like me logo Genes that share compounds with ART4: view

Transcripts for ART4 Gene

mRNA/cDNA for ART4 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ART4 Gene

ADP-ribosyltransferase 4 (Dombrock blood group):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ART4

Alternative Splicing Database (ASD) splice patterns (SP) for ART4 Gene

No ASD Table

Relevant External Links for ART4 Gene

GeneLoc Exon Structure for
ART4
ECgene alternative splicing isoforms for
ART4

Expression for ART4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ART4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART4 Gene

This gene is overexpressed in Liver (x8.6), Heart - Atrial Appendage (x6.8), Artery - Coronary (x6.0), Artery - Aorta (x5.6), and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for ART4 Gene

This gene is overexpressed in Pancreas (62.8) and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ART4 Gene



Protein tissue co-expression partners for ART4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ART4 Gene:

ART4

SOURCE GeneReport for Unigene cluster for ART4 Gene:

Hs.591158

mRNA Expression by UniProt/SwissProt for ART4 Gene:

Q93070-NAR4_HUMAN
Tissue specificity: Expressed in spleen and T-cells.

Evidence on tissue expression from TISSUES for ART4 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ART4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ART4 Gene

Orthologs for ART4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ART4 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia ART4 34 35
  • 79.38 (n)
cow
(Bos Taurus)
Mammalia ART4 34 35
  • 77.7 (n)
rat
(Rattus norvegicus)
Mammalia Art4 34
  • 73.9 (n)
mouse
(Mus musculus)
Mammalia Art4 34 16 35
  • 73.77 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 32 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ART4 34 35
  • 58.48 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100537553 34
  • 47.66 (n)
CABZ01019905.1 35
  • 38 (a)
ManyToMany
CABZ01019905.2 35
  • 35 (a)
ManyToMany
CR846080.5 35
  • 35 (a)
ManyToMany
CR846080.3 35
  • 33 (a)
ManyToMany
si:ch211-51i16.3 35
  • 33 (a)
ManyToMany
si:ch211-51i16.1 35
  • 31 (a)
ManyToMany
BX908804.1 35
  • 30 (a)
ManyToMany
art4 35
  • 29 (a)
ManyToMany
si:ch73-379f5.5 35
  • 29 (a)
ManyToMany
CR846080.4 35
  • 28 (a)
ManyToMany
CABZ01064699.1 35
  • 26 (a)
ManyToMany
si:ch211-163m16.7 35
  • 26 (a)
ManyToMany
CABZ01019904.1 35
  • 25 (a)
ManyToMany
Species where no ortholog for ART4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART4 Gene

ENSEMBL:
Gene Tree for ART4 (if available)
TreeFam:
Gene Tree for ART4 (if available)

Paralogs for ART4 Gene

Paralogs for ART4 Gene

(3) SIMAP similar genes for ART4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ART4: view

Variants for ART4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ART4 Gene

NAR4_HUMAN-Q93070
DO is responsible for the Dombrock blood group system [MIM:616060]. The molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)].

Sequence variations from dbSNP and Humsavar for ART4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11276 other 14,840,505(-) GAGGA(A/G)ACTGG reference, missense
rs56340844 other 14,840,856(-) CTCCA(C/T)AGCAG reference, stop-gained
rs587777831 other 14,841,155(-) TTTAC(A/G)GGTTG splice-acceptor-variant
rs587777832 other 14,840,948(-) AGAAC(-/ATGACTAC)CACAC reference, frameshift-variant
rs587777833 other 14,842,968(-) TGAGG(C/T)AGGGG splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for ART4 Gene

Variant ID Type Subtype PubMed ID
esv3302544 CNV tandem duplication 20981092
esv3437825 CNV duplication 20981092

Variation tolerance for ART4 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ART4 Gene

Human Gene Mutation Database (HGMD)
ART4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ART4

Disorders for ART4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ART4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
arts syndrome
  • arts
- elite association - COSMIC cancer census association via MalaCards
Search ART4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ART4

Genetic Association Database (GAD)
ART4
Human Genome Epidemiology (HuGE) Navigator
ART4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ART4
genes like me logo Genes that share disorders with ART4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ART4 Gene

Publications for ART4 Gene

  1. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. (PMID: 9119374) Koch-Nolte F. … Thiele H.-G. (Genomics 1997) 2 3 4 64
  2. Introduction of a real-time-based blood-group genotyping approach. (PMID: 18510579) Polin H. … Gabriel C. (Vox Sang. 2008) 3 46 64
  3. Analysis of the 3' UTR of the ART3 and ART4 gene by 3' inverse RACE- PCR. (PMID: 16040347) Friedrich M. … Hauschildt S. (DNA Seq. 2005) 3 22 64
  4. Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements. (PMID: 16140404) Grahnert A. … Hauschildt S. (Biochim. Biophys. Acta 2005) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ART4 Gene

  • Addgene plasmids for ART4

Sources for ART4 Gene

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