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GIFtS

ART4 Gene

protein-coding   GIFtS: 56
GCID: GC12M014982

ADP-ribosyltransferase 4 (Dombrock blood group)

(Previous names: ADP-ribosyltransferase 4, Dombrock blood group, ADP-ribosyltransferase...)
(Previous symbol: DO)
 Explore 4 diseases affiliated with
ART4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ART4    

Aliases
for ART4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADP-Ribosyltransferase 4 (Dombrock Blood Group)1 2     Dombrock Blood Group Carrier Molecule2 3
DO1 2 3 5     NAD(P)(+)--Arginine ADP-Ribosyltransferase 42 3
DOK11 2 3 5     ADP-Ribosyltransferase 41
CD2971 2     Dombrock Blood Group1
ADP-Ribosyltransferase 4 (DO Blood Group)1 2     Ecto-ADP-Ribosyltransferase 42
Mono(ADP-Ribosyl)Transferase 42 3     Mono-ADP-Ribosyltransferase 42
ARTC42 3     EC 2.4.2.313
ADP-Ribosyltransferase C2 And C3 Toxin-Like 42 3     CD297 Antigen3

External Ids:    HGNC: 7261   Entrez Gene: 4202   Ensembl: ENSG000001113397   OMIM: 1106005   UniProtKB: Q930703   

Export aliases for ART4 gene to outside databases

Previous GC identifers: GC12M014874 GC12M014751


Summaries
for ART4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ART4:
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the
ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the
Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the
erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. (provided by
RefSeq, Jul 2008)

Gene Wiki entry for ART4


Genomic Views
for ART4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ART4 gene promoter:
         Nkx3-1   C/EBPbeta   Nkx3-1 v4   CUTL1   Nkx3-1 v1   NF-kappaB   Nkx3-1 v2   SEF-1 (1)   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ART4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ART4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ART4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13-p12   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12q13.2-q13.3

ART4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ART4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014982:  view genomic region     (about GC identifiers)

Start:
 14,978,503 bp from pter      End:
 14,996,429 bp from pter
Size:
 17,927 bases      Orientation:
 minus strand

Proteins
for ART4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NAR4_HUMAN, Q93070 (See protein sequence)
Recommended Name: Ecto-ADP-ribosyltransferase 4 precursor  
Size: 314 amino acids; 35878 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q9BZ50 Q9BZ51 Q9HB06

Explore the universe of human proteins at neXtProt for ART4: NX_Q93070

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q93070

    • ART4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066549.2  
    ENSEMBL proteins: 
     ENSP00000228936   ENSP00000412735   ENSP00000442877   ENSP00000405689  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ART4
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    Novus Biologicals ART4 Proteins
    Novus Biologicals ART4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ART4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane NAS9119374
    GO:0031225anchored to membrane IEA--


    ART4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ART4

    Protein Domains /
    Families
    for ART4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ART4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000768 ART

    Graphical View of Domain Structure for InterPro Entry Q93070

    ProtoNet protein and cluster: Q93070

    1 Blocks protein family: IPB000768 NAD:arginine ADP-ribosyltransferase

    UniProtKB/Swiss-Prot: NAR4_HUMAN, Q93070
    Similarity: Belongs to the Arg-specific ADP-ribosyltransferase family


    Function
    for ART4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NAR4_HUMAN, Q93070
    Catalytic activity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
    Catalytic activity: NADP(+) + protein-L-arginine = nicotinamide +
    N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine

         Genatlas biochemistry entry for ART4:
    ADP-ribosyltransferase 4,expressed in testis

    Enzyme Number (IUBMB): EC 2.4.2.311

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ART4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ART4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ART4 (see all 4)
    OriGene shRNA RFP: ART4
    OriGene siRNA: ART4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ART4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ART4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ART4 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ART4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ART4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ART4
    Search LifeMap BioReagents cell lines for ART4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ART4

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity NAS9119374


    ART4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ART4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NAD metabolism
    		NAD metabolism1.00
    		NAD metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ART4
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for ART4
        NAD metabolism



    ART4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ART4

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006471protein ADP-ribosylation NAS9119374
    GO:0006525arginine metabolic process NAS11001920


    ART4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ART4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ART4

    5 HMDB Compounds for ART4    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    Search CenterWatch for drugs/clinical trials and news about ART4 / NAR4 

    Transcripts
    for ART4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ART4 gene: 
    NM_021071.2  

    Unigene Clusters for ART4:

    ADP-ribosyltransferase 4 (Dombrock blood group)
    Hs.591158  [show with all ESTs], Hs.655792  [show with all ESTs], Hs.668803  [show with all ESTs]
    Unigene Representative Sequences: AI149009, AK291662, BX106656
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228936(uc001rcl.1 uc009zid.1 uc009zie.1 uc001rcm.1)
    ENST00000430129 ENST00000544616 ENST00000420600

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ART4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ART4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ART4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ART4 (see all 4)
    OriGene shRNA RFP: ART4
    OriGene siRNA: ART4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ART4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ART4 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ART4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ART4 (NM_021071)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ART4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ART4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ART4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ART4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ART4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ART4

    Additional cDNA sequence: DQ072851.1 

    3 DOTS entries:

    DT.411300  DT.70100710  DT.75179054 

    19 AceView cDNA sequences:

    BX096478 BC074727 W04441 AI190442 NM_021071 AI203531 AF290204 BX501634 
    BU657531 N76036 T70606 N70349 BI760741 W04281 T70872 W04280 
    AW003226 R07939 AW337354 

    GeneLoc Exon Structure


    Expression
    for ART4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ART4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAACTAGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ART4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ART4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ART4

    SOURCE GeneReport for Unigene clusters: Hs.591158 Hs.655792 Hs.668803

    UniProtKB/Swiss-Prot: NAR4_HUMAN, Q93070
    Tissue specificity: Expressed in spleen and T-cells

        SABiosciences Custom PCR Arrays for ART4
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ART4

    Orthologs
    for ART4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ART4 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ART41 ADP-ribosyltransferase 4 (Dombrock blood group) 57.68(n)
    50(a)    		   427879  NM_001142255.1  NP_001135727.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ART36
    		 --
    		 31(a)
    		 possible ortholog
    		 GL343253.1(1869943-1871782)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003341641 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase more 49.66(n)
    42.35(a)    		   100334164  XM_002664165.2  XP_002664211.2 


    ENSEMBL Gene Tree for ART4 (if available)
    TreeFam Gene Tree for ART4 (if available) 

    Paralogs
    for ART4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ART4 gene
    ART52  ART12  ART32  
    3 SIMAP similar genes for ART4 using alignment to 5 protein entries:     NAR4_HUMAN (see all proteins):
    DO    ART5    ART1

    ART4 for paralogs           About GeneDecksing



    Genomic Variants
    for ART4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: NAR4_HUMAN, Q93070
    Polymorphism: DO is responsible for the Dombrock blood group system. The molecular basis of the Do(a)/Do(b) blood group
    antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also
    responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)]


    10/298 NCBI SNPs in ART4 are shown (see all 298)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs563408441,2
    		Cpathogenic14763242(-) CTCCAC/TAGCAG 2 Q * stg10--------
    rs112761,2
    		C,F,O,A,H,pathogenic14993439(-) GAGGAA/GACTGG 2 N D mis1 ese336Minor allele frequency- N:0.00MN NA NS EA WA EU 9337
    rs562948351,2
    		--14752799(-) TCCTCA/C/GCAGAA 1 -- int10--------
    rs796931281,2
    		F,--14752876(+) AAATAC/TATTTC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1119572811,2
    		--14752882(+) ATTTCT/CACTAT 1 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs576829791,2
    		--14753084(+) ATATAC/TACAGT 1 -- int10--------
    rs582697751,2
    		C,--14753103(+) TCTTA-/TTTTTT 1 -- int10--------
    rs745985501,2
    		--14753557(+) TTATGA/GTAGTG 1 -- int10--------
    rs283628041,2
    		C,F,--14754402(-) GTGGTA/GGAGTG 1 -- int15Minor allele frequency- G:0.08NS NA WA 216
    rs562511911,2
    		C,--14754480(+) TATCCC/TCTACT 1 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for ART4 (14978503 - 14996429 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ART4: --
    Human Gene Mutation Database (HGMD): ART4

    Locus Specific Mutation Databases (LSDB): ART4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ART4
    DNA2.0 Custom Variant and Variant Library Synthesis for ART4

    Disorders / Diseases
    for ART4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ART4 for disorders           About GeneDecksing

    OMIM gene information: 110600    OMIM disorders: --

    4 diseases for ART4:    About MalaCards
    acute chest syndrome    cerebral atherosclerosis    atherosclerosis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for ART4:
    Patellofemoral pain syndrome
    Human Genome Epidemiology (HuGE) Navigator: ART4 (3 documents)

    Export disorders for ART4 gene to outside databases

    Publications
    for ART4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ART4 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with ART4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. (PubMed id 9119374)1, 2, 3 Koch-Nolte F.... Thiele H.-G. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Insights into the Holley- and Joseph- phenotypes. (PubMed id 11896313)1, 2 Rios M.... Reid M.E. (2002)
    4. Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors. (PubMed id 11520417)1, 2 Wu G.-G.... Zhao T.-M. (2001)
    5. Identification of the Dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family. (PubMed id 11001920)1, 2 Gubin A.N....Miller J.L. (2000)
    6. Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements. (PubMed id 16140404)1, 9 Grahnert A.... Hauschildt S. (2005)
    7. Analysis of the 3' UTR of the ART3 and ART4 gene by 3' inverse RACE-PCR. (PubMed id 16040347)1, 9 Friedrich M....Hauschildt S. (2005)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Single PCR multiplex SNaPshot reaction for detection of eleven blood group nucleotide polymorphisms: optimization, validation, and o ne year of routine clinical use. (PubMed id 20431033)1 Di Cristofaro J....Bailly P. (2010)
    10. The Dombrock blood group system: a review. (PubMed id 20932078)1 Lomas-Francis C. and Reid M.E. (2010)

    External Searches for ART4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing ART4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 420 HGNC: 726 AceView: DO Ensembl:ENSG00000111339 euGenes: HUgn420
    ECgene: ART4 H-InvDB: ART4

    Other Databases showing ART4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ART4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ART4 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=dombrock
    SeattleSNPshttp://pga.gs.washington.edu/data/do/

    Intellectual Property
    for ART4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ART4 gene:
    Search GeneIP for patents involving ART4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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     Regulatory tfbs in ART4 promoter
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