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ART4 Gene

protein-coding   GIFtS: 60
GCID: GC12M014982

ADP-Ribosyltransferase 4 (Dombrock Blood Group)

(Previous names: Dombrock blood group, ADP-ribosyltransferase 4 (DO blood...)
(Previous symbol: DO)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosyltransferase 4 (Dombrock Blood Group)1 2     ADP-Ribosyltransferase 41
DO1 2 3 5     Dombrock Blood Group1
DOK12 3 5     CD2972
ADP-Ribosyltransferase 4 (DO Blood Group)1 2     Ecto-ADP-Ribosyltransferase 42
ARTC42 3     Mono-ADP-Ribosyltransferase 42
ADP-Ribosyltransferase C2 And C3 Toxin-Like 42 3     EC 2.4.2.313
Dombrock Blood Group Carrier Molecule2 3     CD297 Antigen3
NAD(P)(+)--Arginine ADP-Ribosyltransferase 42 3     Mono(ADP-Ribosyl)Transferase 43

External Ids:    HGNC: 7261   Entrez Gene: 4202   Ensembl: ENSG000001113397   OMIM: 1106005   UniProtKB: Q930703   

Export aliases for ART4 gene to outside databases

Previous GC identifers: GC12M014874 GC12M014751


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ART4 Gene:
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the
ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of
the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored
to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ART4 Gene:
ART4 (ADP-ribosyltransferase 4 (Dombrock blood group)) is a protein-coding gene. Diseases associated with ART4 include patellofemoral pain syndrome, and cerebral atherosclerosis. GO annotations related to this gene include NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART5.

Gene Wiki entry for ART4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ART4 gene promoter:
         Nkx3-1   C/EBPbeta   Nkx3-1 v4   CUTL1   Nkx3-1 v1   NF-kappaB   Nkx3-1 v2   SEF-1 (1)   Nkx3-1 v3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidART4 promoter sequence
   Search Chromatin IP Primers for ART4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ART4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13-p12   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12q13.2-q13.3

ART4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ART4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M014982:  view genomic region     (about GC identifiers)

Start:
14,978,503 bp from pter      End:
14,996,429 bp from pter
Size:
17,927 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NAR4_HUMAN, Q93070 (See protein sequence)
Recommended Name: Ecto-ADP-ribosyltransferase 4 precursor  
Size: 314 amino acids; 35878 Da
Secondary accessions: Q9BZ50 Q9BZ51 Q9HB06

Explore the universe of human proteins at neXtProt for ART4: NX_Q93070

Explore proteomics data for ART4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn114, Asn178, Asn222, Asn257, Asn274
  • Modification sites at PhosphoSitePlus

  • See ART4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066549.2  
    ENSEMBL proteins: 
     ENSP00000228936   ENSP00000412735   ENSP00000442877   ENSP00000405689  

    ART4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for ART4
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    Novus Biologicals ART4 Proteins
    Novus Biologicals ART4 Lysates
    Sino Biological Recombinant Protein for ART4
    Sino Biological Cell Lysate for ART4
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ART4

    ART4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ART4 Antibodies
    Abcam antibodies for ART4
    Cloud-Clone Corp. Antibodies for ART4
    ThermoFisher Antibodies for ART4
    LSBio Antibodies in human, mouse, rat for ART4

    ART4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ART4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ART4
    Cloud-Clone Corp. CLIAs for ART4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    bloodgroup: Blood group antigens

    1 InterPro protein domain:
     IPR000768 ART

    Graphical View of Domain Structure for InterPro Entry Q93070

    ProtoNet protein and cluster: Q93070

    1 Blocks protein domain: IPB000768 NAD:arginine ADP-ribosyltransferase

    UniProtKB/Swiss-Prot: NAR4_HUMAN, Q93070
    Similarity: Belongs to the Arg-specific ADP-ribosyltransferase family


    ART4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAR4_HUMAN, Q93070
    Catalytic activity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine

         Genatlas biochemistry entry for ART4:
    ADP-ribosyltransferase 4,expressed in testis

         Enzyme Number (IUBMB): EC 2.4.2.311

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity NAS9119374
         
    ART4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ART4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ART4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ART4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ART4

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ART4
    Predesigned siRNA for gene silencing in human, mouse, rat ART4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ART4

    Clone
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    OriGene clones in human, mouse for ART4 (see all 6)
    OriGene ORF clones in mouse, rat for ART4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ART4 (NM_021071)
    Sino Biological Human cDNA Clone for ART4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ART4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ART4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ART4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ART4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAR4_HUMAN, Q93070: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane NAS9119374
    GO:0031225anchored component of membrane IEA--

    ART4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ART4 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotinate and nicotinamide metabolism
    NAD metabolism0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ART4
        Fc-Gamma-RIIB Signaling in B-Cells
    GDNF-Family Ligands and Receptor Interactions

    1 GeneGo (Thomson Reuters) Pathway for ART4
        NAD metabolism



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ART4
    Interactions:

        GeneGlobe Interaction Network for ART4

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006471protein ADP-ribosylation NAS9119374
    GO:0006525arginine metabolic process NAS11001920

    ART4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ART4 (NAR4)

    5 HMDB Compounds for ART4    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ART4 gene: 
    NM_021071.2  

    Unigene Clusters for ART4:

    ADP-ribosyltransferase 4 (Dombrock blood group)
    Hs.591158  [show with all ESTs], Hs.655792  [show with all ESTs]
    Unigene Representative Sequences: AI149009, AK291662
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228936(uc001rcl.1 uc009zid.1 uc009zie.1 uc001rcm.1)
    ENST00000430129 ENST00000544616 ENST00000420600
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ART4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ART4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ART4
    Predesigned siRNA for gene silencing in human, mouse, rat ART4
    Clone
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    OriGene clones in human, mouse for ART4 (see all 6)
    OriGene ORF clones in mouse, rat for ART4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ART4 (NM_021071)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ART4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ART4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ART4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ART4
      QuantiTect SYBR Green Assays in human, mouse, rat ART4
      QuantiFast Probe-based Assays in human, mouse, rat ART4

    Additional mRNA sequence: 

    AF290204.1 AK291662.1 AY690666.1 AY829431.1 AY829432.1 AY829433.1 AY829434.1 AY829435.1 
    AY829437.1 BC074727.2 

    2 DOTS entries:

    DT.411300  DT.70100710 

    19 AceView cDNA sequences:

    BX096478 BC074727 W04441 AF290204 BU657531 NM_021071 BX501634 AI203531 
    AI190442 N76036 N70349 T70606 BI760741 W04281 T70872 W04280 
    AW003226 R07939 AW337354 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ART4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAACTAGCC
    ART4 Expression
    About this image


    ART4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Eye (Sensory Organs)
             Lens
     
     Spleen (Hematopoietic System)
    ART4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ART4 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.591158 Hs.655792

    UniProtKB/Swiss-Prot: NAR4_HUMAN, Q93070
    Tissue specificity: Expressed in spleen and T-cells

        Custom PCR Arrays for ART4
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    QuantiFast Probe-based Assays in human, mouse, rat ART4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ART4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ART4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Art41 , 5 ADP-ribosyltransferase 41, 5 73.77(n)1
    64.26(a)1
      6 (66.72 cM)5
    1099781  NM_026639.21  NP_080915.11 
     1368484515 
    chicken
    (Gallus gallus)
    Aves ART41 ADP-ribosyltransferase 4 (Dombrock blood group) 58.48(n)
    50.86(a)
      427879  NM_001142255.1  NP_001135727.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    many ↔ many
    GL343834.1(66228-69795)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005375531 NAD(P)(+)--arginine ADP-ribosyltransferase 2-like 47.66(n)
    41.12(a)
      100537553  XM_003198042.2  XP_003198090.2 


    ENSEMBL Gene Tree for ART4 (if available)
    TreeFam Gene Tree for ART4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ART4 gene
    ART52  ART12  ART32  
    3 SIMAP similar genes for ART4 using alignment to 5 protein entries:     NAR4_HUMAN (see all proteins):
    DO    ART5    ART1

    ART4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    NAR4_HUMAN, Q93070: DO is responsible for the Dombrock blood group system. The molecular basis of the Do(a)/Do(b) blood
    group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is
    also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)]


    Selected SNPs for ART4 (see all 353)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112761,2,,4
    C,F,O,A,Hpathogenic114862266(-) GAGGAA/GACTGG 2 N D mis1 ese336Minor allele frequency- N:0.00MN NA NS EA WA EU 9337
    rs563408441,2
    Cpathogenic114862617(-) CTCCAC/TAGCAG 2 Q * stg10--------
    rs576829791,2
    --14753084(+) ATATAC/TACAGT 1 -- int10--------
    rs1879004991,2
    --14850967(+) TAAATA/GTCCAT 1 -- ds50010--------
    rs1931476271,2
    C--14851044(+) GATTTC/GTTTAT 1 -- ut310--------
    rs30881901,2,,4
    C,F,H--14851093(+) GGAGAG/CAGATG 2 /L /V mis1 ese3 trp327Minor allele frequency- C:0.10MN NS EA NA CSA WA EU 8797
    rs1997816901,2
    C--14851120(+) AGGGAG/TGCATT 2 I L mis10--------
    rs1856451331,2
    --14851261(+) TAGCTA/GCTTAA 1 -- int10--------
    rs1174789611,2
    F--14851359(+) GGTAAC/TCCAGC 1 -- int11Minor allele frequency- T:0.01NA 120
    rs118353631,2
    C,F,A,H--14851441(+) CATCTT/CAATTA 1 -- int121Minor allele frequency- C:0.20NS EA NA WA 2346

    HapMap Linkage Disequilibrium report for ART4 (14978503 - 14996429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ART4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898817CNV Gain21882294
    esv259518OTHER Complex20981092

    Human Gene Mutation Database (HGMD): ART4
    Locus Specific Mutation Databases (LSDB): ART4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ART4
    DNA2.0 Custom Variant and Variant Library Synthesis for ART4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 110600    OMIM disorders: --

    6 diseases for ART4:    
    About MalaCards
    patellofemoral pain syndrome    cerebral atherosclerosis    acute chest syndrome    paine syndrome
    atherosclerosis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for ART4:
    Acute chest syndrome

    ART4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ART4
    Human Genome Epidemiology (HuGE) Navigator: ART4 (3 documents)

    Export disorders for ART4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ART4 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with ART4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. (PubMed id 9119374)1, 2, 3 Koch-Nolte F.... Thiele H.-G. (Genomics 1997)
    2. Introduction of a real-time-based blood-group genotyping approach. (PubMed id 18510579)1, 4 Polin H....Gabriel C. (Vox Sang. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Insights into the Holley- and Joseph- phenotypes. (PubMed id 11896313)1, 2 Rios M.... Reid M.E. (Transfusion 2002)
    5. Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors. (PubMed id 11520417)1, 2 Wu G.-G.... Zhao T.-M. (Vox Sang. 2001)
    6. Identification of the Dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family. (PubMed id 11001920)1, 2 Gubin A.N....Miller J.L. (Blood 2000)
    7. Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements. (PubMed id 16140404)1, 9 Grahnert A.... Hauschildt S. (Biochim. Biophys. Acta 2005)
    8. Analysis of the 3' UTR of the ART3 and ART4 gene by 3' inverse RACE- PCR. (PubMed id 16040347)1, 9 Friedrich M.... Hauschildt S. (DNA Seq. 2005)
    9. The production, serologic evaluation, and epitope mapping of ten murine monoclonal Dombrock antibodies. (PubMed id 23421541)1 Grodecka M....Lisowska E. (Immunohematology 2012)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 420 HGNC: 726 AceView: DO Ensembl:ENSG00000111339 euGenes: HUgn420
    ECgene: ART4 H-InvDB: ART4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ART4 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=dombrock
    SeattleSNPshttp://pga.gs.washington.edu/data/do/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ART4 gene:
    Search GeneIP for patents involving ART4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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