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Aliases for ART4 Gene

Aliases for ART4 Gene

  • ADP-Ribosyltransferase 4 (Dombrock Blood Group) 2 3 5
  • NAD(+)--Protein-Arginine ADP-Ribosyltransferase 4 2 3
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 4 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 4 3 4
  • ADP-Ribosyltransferase 4 (DO Blood Group) 2 3
  • Dombrock Blood Group Carrier Molecule 3 4
  • ARTC4 3 4
  • DOK1 3 4
  • DO 3 4
  • Mono(ADP-Ribosyl)Transferase 4 4
  • Mono-ADP-Ribosyltransferase 4 3
  • ADP-Ribosyltransferase 4 2
  • Dombrock Blood Group 2
  • CD297 Antigen 4
  • EC 4
  • CD297 3

External Ids for ART4 Gene

Previous HGNC Symbols for ART4 Gene

  • DO

Previous GeneCards Identifiers for ART4 Gene

  • GC12M014874
  • GC12M014982
  • GC12M014751

Summaries for ART4 Gene

Entrez Gene Summary for ART4 Gene

  • This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ART4 Gene

ART4 (ADP-Ribosyltransferase 4 (Dombrock Blood Group)) is a Protein Coding gene. Among its related pathways are NAD metabolism. GO annotations related to this gene include NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART1.

Gene Wiki entry for ART4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART4 Gene

Genomics for ART4 Gene

Regulatory Elements for ART4 Gene

Enhancers for ART4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ART4 on UCSC Golden Path with GeneCards custom track

Promoters for ART4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ART4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ART4 Gene

14,825,569 bp from pter
14,843,495 bp from pter
17,927 bases
Minus strand

Genomic View for ART4 Gene

Genes around ART4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ART4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ART4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART4 Gene

Proteins for ART4 Gene

  • Protein details for ART4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ecto-ADP-ribosyltransferase 4
    Protein Accession:
    Secondary Accessions:
    • Q9BZ50
    • Q9BZ51
    • Q9HB06

    Protein attributes for ART4 Gene

    314 amino acids
    Molecular mass:
    35878 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ART4 Gene

Proteomics data for ART4 Gene at MOPED

Post-translational modifications for ART4 Gene

  • Glycosylation at Asn 114, Asn 178, Asn 222, Asn 257, and Asn 274
  • Modification sites at PhosphoSitePlus

Other Protein References for ART4 Gene

No data available for DME Specific Peptides for ART4 Gene

Domains & Families for ART4 Gene

Gene Families for ART4 Gene

Protein Domains for ART4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Arg-specific ADP-ribosyltransferase family.
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART4: view

Function for ART4 Gene

Molecular function for ART4 Gene

GENATLAS Biochemistry:
ADP-ribosyltransferase 4,expressed in testis
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Enzyme Numbers (IUBMB) for ART4 Gene

genes like me logo Genes that share phenotypes with ART4: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ART4 Gene

Localization for ART4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART4 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for ART4 Gene COMPARTMENTS Subcellular localization image for ART4 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ART4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane NAS 9119374
genes like me logo Genes that share ontologies with ART4: view

Pathways & Interactions for ART4 Gene

SuperPathways for ART4 Gene

Superpath Contained pathways
1 NAD metabolism
genes like me logo Genes that share pathways with ART4: view

Pathways by source for ART4 Gene

1 GeneGo (Thomson Reuters) pathway for ART4 Gene

Interacting Proteins for ART4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000228936 for ART4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ART4 Gene


No data available for SIGNOR curated interactions for ART4 Gene

Drugs & Compounds for ART4 Gene

(4) Drugs for ART4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist 0
Nicotinamide Experimental Nutra 850,854
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(1) Additional Compounds for ART4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
genes like me logo Genes that share compounds with ART4: view

Transcripts for ART4 Gene

mRNA/cDNA for ART4 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ART4 Gene

ADP-ribosyltransferase 4 (Dombrock blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ART4 Gene

No ASD Table

Relevant External Links for ART4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ART4 Gene

mRNA expression in normal human tissues for ART4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART4 Gene

This gene is overexpressed in Liver (x8.6), Heart - Atrial Appendage (x6.8), Artery - Coronary (x6.0), Artery - Aorta (x5.6), and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for ART4 Gene

This gene is overexpressed in Pancreas (62.8) and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ART4 Gene

SOURCE GeneReport for Unigene cluster for ART4 Gene Hs.591158

mRNA Expression by UniProt/SwissProt for ART4 Gene

Tissue specificity: Expressed in spleen and T-cells.
genes like me logo Genes that share expression patterns with ART4: view

Protein tissue co-expression partners for ART4 Gene

Primer Products

Orthologs for ART4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ART4 35
  • 77.7 (n)
  • 66.56 (a)
ART4 36
  • 61 (a)
(Canis familiaris)
Mammalia ART4 35
  • 79.38 (n)
  • 66.99 (a)
ART4 36
  • 65 (a)
(Mus musculus)
Mammalia Art4 35
  • 73.77 (n)
  • 64.26 (a)
Art4 16
Art4 36
  • 62 (a)
(Pan troglodytes)
Mammalia ART4 35
  • 99.68 (n)
  • 99.36 (a)
ART4 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Art4 35
  • 73.9 (n)
  • 64.71 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
(Gallus gallus)
Aves ART4 35
  • 58.48 (n)
  • 50.86 (a)
ART4 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
(Danio rerio)
Actinopterygii LOC100537553 35
  • 47.66 (n)
  • 41.12 (a)
art4 36
  • 29 (a)
BX908804.1 36
  • 30 (a)
CABZ01019904.1 36
  • 25 (a)
CABZ01019905.1 36
  • 38 (a)
CABZ01019905.2 36
  • 35 (a)
CABZ01064699.1 36
  • 26 (a)
CR846080.3 36
  • 33 (a)
CR846080.4 36
  • 28 (a)
CR846080.5 36
  • 35 (a)
si:ch211-163m16.7 36
  • 26 (a)
si:ch211-51i16.1 36
  • 31 (a)
si:ch211-51i16.3 36
  • 33 (a)
si:ch73-379f5.5 36
  • 29 (a)
Species with no ortholog for ART4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART4 Gene

Gene Tree for ART4 (if available)
Gene Tree for ART4 (if available)

Paralogs for ART4 Gene

Paralogs for ART4 Gene

(3) SIMAP similar genes for ART4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ART4: view

Variants for ART4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ART4 Gene

DO is responsible for the Dombrock blood group system [MIM:616060]. The molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)].

Sequence variations from dbSNP and Humsavar for ART4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs28362797 - 14,840,975(-) CCAAG(G/T)AAAAG reference, missense
rs28362798 - 14,840,948(-) GACTA(A/C/T)CACAC reference, missense
rs11276 - 14,840,505(-) GAGGA(A/G)ACTGG reference, missense
rs3088190 - 14,829,418(+) GGAGA(C/G)AGATG reference, missense
rs28362799 - 14,840,893(-) TCTGA(A/C)TTTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ART4 Gene

Variant ID Type Subtype PubMed ID
nsv898817 CNV Gain 21882294
esv259518 OTHER Complex 20981092

Variation tolerance for ART4 Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ART4 Gene

Human Gene Mutation Database (HGMD)

Disorders for ART4 Gene

Relevant External Links for ART4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ART4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ART4 Gene

Publications for ART4 Gene

  1. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. (PMID: 9119374) Koch-Nolte F. … Thiele H.-G. (Genomics 1997) 2 3 4 67
  2. Analysis of the 3' UTR of the ART3 and ART4 gene by 3' inverse RACE- PCR. (PMID: 16040347) Friedrich M. … Hauschildt S. (DNA Seq. 2005) 3 23
  3. Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements. (PMID: 16140404) Grahnert A. … Hauschildt S. (Biochim. Biophys. Acta 2005) 3 23
  4. Sequencing of the ART4 gene in sub-Saharan cohorts reveals ethnic differences and two new DO alleles: DO*B-Ile5Thr and DO*B-Trp266Arg. (PMID: 25988428) Durousseau de Coulgeans C. … Chapel-Fernandes S. (Transfusion 2015) 3
  5. The production, serologic evaluation, and epitope mapping of ten murine monoclonal Dombrock antibodies. (PMID: 23421541) Grodecka M. … Lisowska E. (Immunohematology 2012) 3

Products for ART4 Gene

Sources for ART4 Gene