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Aliases for ART3 Gene

Aliases for ART3 Gene

  • ADP-Ribosyltransferase 3 2 3
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 3 3 4
  • NAD(P)(+)--Arginine ADP-Ribosyltransferase 3 3 4
  • Mono(ADP-Ribosyl)Transferase 3 3 4
  • ARTC3 3 4
  • Mono-ADP-Ribosyltransferase 3
  • EC 4
  • TMART 4

External Ids for ART3 Gene

Previous GeneCards Identifiers for ART3 Gene

  • GC04P076891
  • GC04P077186
  • GC04P077325
  • GC04P077454
  • GC04P077353
  • GC04P076932
  • GC04P072684

Summaries for ART3 Gene

Entrez Gene Summary for ART3 Gene

  • This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for ART3 Gene

ART3 (ADP-Ribosyltransferase 3) is a Protein Coding gene. Among its related pathways are NAD metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART1.

Gene Wiki entry for ART3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART3 Gene

Genomics for ART3 Gene

Regulatory Elements for ART3 Gene

Genomic Location for ART3 Gene

76,011,180 bp from pter
76,112,802 bp from pter
101,623 bases
Plus strand

Genomic View for ART3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ART3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART3 Gene

Proteins for ART3 Gene

  • Protein details for ART3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ecto-ADP-ribosyltransferase 3
    Protein Accession:
    Secondary Accessions:
    • Q53XW3
    • Q6FHT7
    • Q8WVJ7
    • Q93069
    • Q96HL1

    Protein attributes for ART3 Gene

    389 amino acids
    Molecular mass:
    43923 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ART3 Gene


neXtProt entry for ART3 Gene

Proteomics data for ART3 Gene at MOPED

Post-translational modifications for ART3 Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Asn 248 and Thr 346
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ART3 Gene

Domains & Families for ART3 Gene

Protein Domains for ART3 Gene

Suggested Antigen Peptide Sequences for ART3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Arg-specific ADP-ribosyltransferase family.
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART3: view

No data available for Gene Families for ART3 Gene

Function for ART3 Gene

Molecular function for ART3 Gene

GENATLAS Biochemistry:
ADP-ribosyltransferase 3,expressed in testis
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine

Enzyme Numbers (IUBMB) for ART3 Gene

Gene Ontology (GO) - Molecular Function for ART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity TAS 9119374
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
genes like me logo Genes that share ontologies with ART3: view
genes like me logo Genes that share phenotypes with ART3: view

Animal Model Products

miRNA for ART3 Gene

miRTarBase miRNAs that target ART3

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ART3 Gene

Localization for ART3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART3 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for ART3 Gene COMPARTMENTS Subcellular localization image for ART3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9119374
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ART3: view

Pathways & Interactions for ART3 Gene

SuperPathways for ART3 Gene

Superpath Contained pathways
1 NAD metabolism
genes like me logo Genes that share pathways with ART3: view

Pathways by source for ART3 Gene

1 GeneGo (Thomson Reuters) pathway for ART3 Gene

Interacting Proteins for ART3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000348064 for ART3 Gene via STRING

Gene Ontology (GO) - Biological Process for ART3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA --
genes like me logo Genes that share ontologies with ART3: view

No data available for SIGNOR curated interactions for ART3 Gene

Drugs & Compounds for ART3 Gene

(5) Drugs for ART3 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist 0
Nicotinamide Experimental Nutra 332,340
NAD Pharma Agonist, Activator 0
NADH Nutra 0
arginine Nutra 346

(4) Additional Compounds for ART3 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with ART3: view

Transcripts for ART3 Gene

Unigene Clusters for ART3 Gene

ADP-ribosyltransferase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ART3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ART3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP2: - -

Relevant External Links for ART3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ART3 Gene

mRNA expression in normal human tissues for ART3 Gene

mRNA differential expression in normal tissues according to GTEx for ART3 Gene

This gene is overexpressed in Muscle - Skeletal (x18.2), Heart - Left Ventricle (x7.5), Heart - Atrial Appendage (x6.0), and Testis (x5.4).

Protein differential expression in normal tissues from HIPED for ART3 Gene

This gene is overexpressed in Ovary (29.3), Testis (25.4), and Serum (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ART3 Gene

SOURCE GeneReport for Unigene cluster for ART3 Gene Hs.24976

mRNA Expression by UniProt/SwissProt for ART3 Gene

Tissue specificity: Testis specific
genes like me logo Genes that share expression patterns with ART3: view

Protein tissue co-expression partners for ART3 Gene

Primer Products

In Situ Assay Products

Orthologs for ART3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ART3 35
  • 83.07 (n)
  • 74.33 (a)
ART3 36
  • 72 (a)
(Canis familiaris)
Mammalia ART3 35
  • 84.68 (n)
  • 74.55 (a)
ART3 36
  • 73 (a)
(Mus musculus)
Mammalia Art3 35
  • 72.39 (n)
  • 64.79 (a)
Art3 16
Art3 36
  • 63 (a)
(Pan troglodytes)
Mammalia ART3 35
  • 98.18 (n)
  • 97.55 (a)
ART3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Art3 35
  • 69.61 (n)
  • 58.82 (a)
(Monodelphis domestica)
Mammalia ART3 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia ART3 36
  • 31 (a)
(Gallus gallus)
Aves -- 36
  • 36 (a)
-- 36
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia art5 35
  • 51 (n)
  • 39.76 (a)
(Danio rerio)
Actinopterygii art4 36
  • 23 (a)
BX908804.1 36
  • 24 (a)
CABZ01019904.1 36
  • 21 (a)
CABZ01019905.1 36
  • 30 (a)
CABZ01019905.2 36
  • 27 (a)
CABZ01064699.1 36
  • 25 (a)
CR846080.3 36
  • 30 (a)
CR846080.4 36
  • 23 (a)
CR846080.5 36
  • 27 (a)
si:ch211-163m16.7 36
  • 21 (a)
si:ch211-51i16.1 36
  • 23 (a)
si:ch211-51i16.3 36
  • 27 (a)
si:ch73-379f5.5 36
  • 24 (a)
Species with no ortholog for ART3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART3 Gene

Gene Tree for ART3 (if available)
Gene Tree for ART3 (if available)

Paralogs for ART3 Gene

Paralogs for ART3 Gene

(1) SIMAP similar genes for ART3 Gene using alignment to 8 proteins: Pseudogenes for ART3 Gene

genes like me logo Genes that share paralogs with ART3: view

Variants for ART3 Gene

Sequence variations from dbSNP and Humsavar for ART3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_060072 -

Structural Variations from Database of Genomic Variants (DGV) for ART3 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
esv2662680 CNV Deletion 23128226
esv1621359 CNV Insertion 17803354
nsv293489 CNV Insertion 16902084
esv2427313 CNV Deletion 19546169
esv2225549 CNV Deletion 18987734
nsv821336 CNV Deletion 20802225
esv27112 CNV Gain 19812545
nsv292553 CNV Loss 16902084
esv2727841 CNV Deletion 23290073
esv2660008 CNV Deletion 23128226
nsv513139 CNV Loss 21212237
esv2727842 CNV Deletion 23290073
esv272627 CNV Insertion 20981092
esv2676154 CNV Deletion 23128226
esv269359 CNV Insertion 20981092
nsv470047 CNV Gain 18288195
nsv461558 CNV Gain 19166990

Variation tolerance for ART3 Gene

Residual Variation Intolerance Score: 60.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ART3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART3 Gene

Disorders for ART3 Gene

Relevant External Links for ART3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ART3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ART3 Gene

Publications for ART3 Gene

  1. LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma. (PMID: 20419844) Huang G.L. … Wang H.Y. (World J. Gastroenterol. 2010) 23 67
  2. Pharmacological manipulations of CNS sirtuins: potential effects on metabolic homeostasis. (PMID: 20138996) Ramadori G. … Coppari R. (Pharmacol. Res. 2010) 23 67
  3. NAD+ and vitamin B3: from metabolism to therapies. (PMID: 18165311) Sauve A.A. (J. Pharmacol. Exp. Ther. 2008) 23 67
  4. Conserved metabolic regulatory functions of sirtuins. (PMID: 18249170) Schwer B. … Verdin E. (Cell Metab. 2008) 23 67
  5. Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. (PMID: 18266473) Okada H. … Inoue I. (PLoS Genet. 2008) 23 67

Products for ART3 Gene

Sources for ART3 Gene

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