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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ART1 Gene

protein-coding   GIFtS: 60
GCID: GC11P003666

ADP-ribosyltransferase 1
 Explore 7 diseases affiliated with
ART1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ART1    

Aliases
for ART1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADP-Ribosyltransferase 11 2     RT62
ART21 2     ADP-Ribosyltransferase 22
CD2961 2     GPI-Linked NAD(P)(+)--Arginine ADP-Ribosyltransferase 12
Mono(ADP-Ribosyl)Transferase 12 3     EC 2.4.2.313
ARTC12 3     CD296 Antigen3
ADP-Ribosyltransferase C2 And C3 Toxin-Like 12 3     

External Ids:    HGNC: 7231   Entrez Gene: 4172   Ensembl: ENSG000001297447   OMIM: 6016255   UniProtKB: P529613   

Export aliases for ART1 gene to outside databases

Previous GC identifers: GC11P004241 GC11P003935 GC11P003625 GC11P003630 GC11P003622 GC11P003403


Summaries
for ART1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ART1:
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a
posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera,
pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N-
and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was
previously designated ART2. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961
Function: Has ADP-ribosyltransferase activity toward GLP1R




Genomic Views
for ART1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ART1 gene promoter:
         SRF   E2F-4   E2F-3a   E2F-5   FOXF2   SRF (504 AA)   E2F-2   E2F-1   E2F   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ART1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ART1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ART1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

ART1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ART1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P003666:  view genomic region     (about GC identifiers)

Start:
 3,666,358 bp from pter      End:
 3,685,646 bp from pter
Size:
 19,289 bases      Orientation:
 plus strand

Proteins
for ART1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961 (See protein sequence)
Recommended Name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor  
Size: 327 amino acids; 36335 Da
Subcellular location: Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q6NTD2 Q96KT9

Explore the universe of human proteins at neXtProt for ART1: NX_P52961

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52961

    • ART1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004305.2  
    ENSEMBL proteins: 
     ENSP00000250693  
    Reactome Protein details: P52961
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ART1
    OriGene Custom Protein Services for ART1 
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    Novus Biologicals ART1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ART1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7947688
    GO:0009986cell surface IEA--
    GO:0031225anchored to membrane IEA--
    GO:0033017sarcoplasmic reticulum membrane IEA--


    ART1 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for ART1

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    Uscn ELISAs and CLIAs for ART1

    Protein Domains /
    Families
    for ART1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ART1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000768 ART

    Graphical View of Domain Structure for InterPro Entry P52961

    ProtoNet protein and cluster: P52961

    1 Blocks protein family: IPB000768 NAD:arginine ADP-ribosyltransferase

    UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961
    Similarity: Belongs to the Arg-specific ADP-ribosyltransferase family


    Function
    for ART1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961
    Function: Has ADP-ribosyltransferase activity toward GLP1R
    Catalytic activity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
    Catalytic activity: NADP(+) + protein-L-arginine = nicotinamide +
    N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine

         Genatlas biochemistry entry for ART1:
    ADP ribosyltransferase 1,expressed in muscle

    Enzyme Number (IUBMB): EC 2.4.2.311

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ART1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ART1:
    hsa-miR-214 hsa-miR-629* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: ART1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ART1 (see all 7)
    OriGene shRNA RFP: ART1
    OriGene siRNA: ART1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ART1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ART1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ART1 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ART1 (NM_004314)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ART1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ART1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ART1
    Search LifeMap BioReagents cell lines for ART1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ART1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA--


    ART1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Art1tm1Lex for ART1
         1 MGI phenotypic allele for Art1 (no phenotypes)

    ART1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ART1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1NAD metabolism
    		NAD metabolism1.00
    		NAD metabolism1.00
    2Immune System
    		Immune System1.00
    		Innate Immune System0.46
    3Alpha-defensins
    		Alpha-defensins1.00
    4Beta defensins
    		Defensins0.80

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ART1
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for ART1
        NAD metabolism

    4        Reactome Pathways for ART1
        Defensins
    Alpha-defensins
    Immune System
    Innate Immune System



    ART1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ART1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ART1 (P529613 ENSP000002506934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDGFBP011273, ENSP000003303824I2D: score=1 STRING: ENSP00000330382
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006471protein ADP-ribosylation IEA--
    GO:0045087innate immune response TAS--


    ART1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ART1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ART1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ART1

    5 HMDB Compounds for ART1    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--

    2 DrugBank Compounds for ART1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-Bromonicotinamide-- 28733-43-9target--17139284 17016423 10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235

    4 Novoseek chemical compound relationships for ART1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpribose 84 1 11498506 (1)
    agmatine 74.1 2 11498506 (1)
    nad+ 63.3 2 10460751 (1), 11498506 (1)
    carbon 43 31 16453289 (6), 15078170 (4), 11587854 (3), 14563321 (2) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about ART1 / NAR1 

    Transcripts
    for ART1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ART1 gene: 
    NM_004314.2  

    Unigene Cluster for ART1:

    ADP-ribosyltransferase 1
    Hs.382188
    Unigene Representative Sequence: NM_004314
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529556 ENST00000250693(uc009yeb.1 uc001lye.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ART1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ART1:
    hsa-miR-214 hsa-miR-629* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: ART1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ART1 (see all 7)
    OriGene shRNA RFP: ART1
    OriGene siRNA: ART1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ART1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ART1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ART1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ART1 (NM_004314)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ART1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ART1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ART1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ART1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ART1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ART1

    Additional cDNA sequence: 

    AJ291430.1 BC017828.1 BC069102.1 BC069828.1 BC111729.1 S74683.1 

    2 DOTS entries:

    DT.91749828  DT.91997175 

    7 AceView cDNA sequences:

    AJ291430 BC069102 BC069828 S74683 NM_004314 BC017828 BF790114 

    GeneLoc Exon Structure


    Expression
    for ART1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ART1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGCTTCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ART1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    BoneZeugopod Long BoneBone
    LimbAutopodLimb
    LimbZeugopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ART1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ART1

    SOURCE GeneReport for Unigene cluster: Hs.382188
        SABiosciences Custom PCR Arrays for ART1
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ART1

    Orthologs
    for ART1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ART1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MADPRT6
    --
    (see all 7)    		 Uncharacterized protein
    (see all 7)    		 46(a)
    44(a)
    (see all 7)    		 1 ↔ many
    1 ↔ many
    (see all 7)    		 1(199097429-199100420)
    3(17836877-17838678)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 7)    		 --
    		 48(a)
    48(a)
    (see all 7)    		 1 ↔ many
    1 ↔ many
    (see all 7)    		 GL344444.1(28723-32849)
    AAWZ02040529(161-2852)
    zebrafish
    (Danio rerio)    		 Actinopterygii CABZ01019905.16
    CR846080.46
    (see all 14)    		 --
    		 37(a)
    34(a)
    (see all 14)    		 many ↔ many
    many ↔ many
    (see all 14)    		 3(7938826-7939488)
    3(10211463-10212240)


    ENSEMBL Gene Tree for ART1 (if available)
    TreeFam Gene Tree for ART1 (if available) 

    Paralogs
    for ART1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ART1 gene
    ART42  ART52  ART32  
    3 SIMAP similar genes for ART1 using alignment to 1 protein entry:     NAR1_HUMAN:
    ART5    ART4    DO

    ART1 for paralogs           About GeneDecksing



    Genomic Variants
    for ART1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/637 NCBI SNPs in ART1 are shown (see all 637)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs728443271,2
    		C,--3664407(+) CTGTAG/CACCAA 3 -- us2k13Minor allele frequency- C:0.07CSA WA NA 240
    rs1924622691,2
    		--3664408(+) TGTAGA/GCCAAA 3 -- us2k10--------
    rs65784101,2
    		C,F,A,H,--3664427(+) CATACG/TGTGGG 3 -- us2k126Minor allele frequency- T:0.23NS EA NA WA CSA 2622
    rs1512926091,2
    		C,--3664457(+) GGGGA-/GGGAGG 3 -- us2k10--------
    rs1838472711,2
    		--3664528(+) AATCCC/TAGCAC 3 -- us2k10--------
    rs1876984641,2
    		--3664544(+) GAGGCC/TGAAGT 3 -- us2k10--------
    rs1420416811,2
    		--3664563(+) CACGAC/GGTCAG 3 -- us2k10--------
    rs1511744751,2
    		--3664604(+) TAGCCA/GGGCGT 3 -- us2k10--------
    rs1914633891,2
    		--3664620(+) CAGGGA/GCCTGT 3 -- us2k10--------
    rs1836517091,2
    		--3664692(+) CAGTGA/GGCTGA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ART1 (3666358 - 3685646 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for ART1
         3 CNVs: 3833 71243 71242
         2 Indels: 33234 33535

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ART1
    DNA2.0 Custom Variant and Variant Library Synthesis for ART1

    Disorders / Diseases
    for ART1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ART1 for disorders           About GeneDecksing

    OMIM gene information: 601625    OMIM disorders: --

    7 diseases for ART1:    About MalaCards
    pertussis    cholera    squamous cell carcinoma of the head and neck    squamous cell carcinoma
    lymphopenia    diphtheria    carcinoma

    1 disease from the University of Copenhagen DISEASES database for ART1:
    Cholera

    Export disorders for ART1 gene to outside databases

    Publications
    for ART1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ART1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with ART1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7. (PubMed id 8812442)1, 3 Koch-Nolte F....Thiele H.G. (1996)
    2. Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. (PubMed id 7947688)1, 2 Okazaki I.J.... Moss J. (1994)
    3. ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (PubMed id 16627471)1, 9 Paone G....Moss J. (2006)
    4. Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs. (PubMed id 10092875)1, 9 Kefalas P....MacDermot J. (1999)
    5. Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase. (PubMed id 11498506)1, 9 Saxty B.A....MacDermot J. (2001)
    6. Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase. (PubMed id 21901419)2 Dezelak M. and Bavec A. (2011)
    7. Toward a unified nomenclature for mammalian ADP- ribosyltransferases. (PubMed id 20106667)2 Hottiger M.O.... Koch-Nolte F. (2010)
    8. Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. (PubMed id 17614107)1 Li C....Wei Q. (2007)
    9. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)

    External Searches for ART1 gene

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    Genome Databases showing ART1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 417 HGNC: 723 AceView: ART1 Ensembl:ENSG00000129744 euGenes: HUgn417
    ECgene: ART1 H-InvDB: ART1

    Other Databases showing ART1 gene

    (According to HUGE)
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    Specialized Databases showing ART1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ART1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ART1 gene

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    About This Section
    		Patent Information for ART1 gene:
    Search GeneIP for patents involving ART1

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