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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ART1 Gene

protein-coding   GIFtS: 61
GCID: GC11P003666

ADP-Ribosyltransferase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosyltransferase 11 2     RT62
Mono(ADP-Ribosyl)Transferase 12 3     ADP-Ribosyltransferase 22
ARTC12 3     GPI-Linked NAD(P)(+)--Arginine ADP-Ribosyltransferase 12
ADP-Ribosyltransferase C2 And C3 Toxin-Like 12 3     EC 2.4.2.313
ART22     CD296 Antigen3
CD2962     

External Ids:    HGNC: 7231   Entrez Gene: 4172   Ensembl: ENSG000001297447   OMIM: 6016255   UniProtKB: P529613   

Export aliases for ART1 gene to outside databases

Previous GC identifers: GC11P004241 GC11P003935 GC11P003625 GC11P003630 GC11P003622 GC11P003403


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ART1 Gene:
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a
posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including
cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly
hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored
proteins. This gene was previously designated ART2. (provided by RefSeq, Jul 2008)

GeneCards Summary for ART1 Gene: 
ART1 (ADP-ribosyltransferase 1) is a protein-coding gene. Diseases associated with ART1 include pertussis, and cholera, and among its related super-pathways are Immune System and Beta defensins. GO annotations related to this gene include NAD(P)+-protein-arginine ADP-ribosyltransferase activity and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is ART4.

UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961
Function: Has ADP-ribosyltransferase activity toward GLP1R




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ART1 gene promoter:
         SRF   E2F-4   E2F-3a   E2F-5   FOXF2   SRF (504 AA)   E2F-2   E2F-1   E2F   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidART1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ART1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ART1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

ART1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ART1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P003666:  view genomic region     (about GC identifiers)

Start:
3,666,358 bp from pter      End:
3,685,646 bp from pter
Size:
19,289 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961 (See protein sequence)
Recommended Name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor  
Size: 327 amino acids; 36335 Da
Subcellular location: Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q6NTD2 Q96KT9

Explore the universe of human proteins at neXtProt for ART1: NX_P52961

Explore proteomics data for ART1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52961

  • ART1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ART1 Protein Expression
    REFSEQ proteins: NP_004305.2  
    ENSEMBL proteins: 
     ENSP00000250693  
    Reactome Protein details: P52961
    Human Recombinant Protein Products for ART1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ART1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ART1
    GenScript Custom Purified and Recombinant Proteins Services for ART1
    Novus Biologicals ART1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ART1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS7947688
    GO:0009986cell surface IEA--
    GO:0031225anchored to membrane IEA--
    GO:0033017sarcoplasmic reticulum membrane IEA--

    ART1 for ontologies           About GeneDecksing



    ART1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ART1 Antibody
    Abcam antibodies for ART1
    Cloud-Clone Corp. Antibodies for ART1 
    ThermoFisher Antibodies for ART1
    LSBio Antibodies in human, mouse, rat for ART1 

    Assay Products for ART1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ART1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ART1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ART1 
    Cloud-Clone Corp. CLIAs for ART1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    1 InterPro protein domain:
     IPR000768 ART

    Graphical View of Domain Structure for InterPro Entry P52961

    ProtoNet protein and cluster: P52961

    1 Blocks protein domain: IPB000768 NAD:arginine ADP-ribosyltransferase

    UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961
    Similarity: Belongs to the Arg-specific ADP-ribosyltransferase family


    ART1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAR1_HUMAN, P52961
    Function: Has ADP-ribosyltransferase activity toward GLP1R
    Catalytic activity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
    Catalytic activity: NADP(+) + protein-L-arginine = nicotinamide +
    N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine

         Genatlas biochemistry entry for ART1:
    ADP ribosyltransferase 1,expressed in muscle

         Enzyme Number (IUBMB): EC 2.4.2.311

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA--
         
    ART1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Art1 (no phenotypes)

    ART1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Art1tm1Lex for ART1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ART1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ART1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ART1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ART1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ART1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ART1:
    hsa-miR-214 hsa-miR-629* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidART1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ART1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ART1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ART1
    Sirion Biotech Customized adenovirus for overexpression of ART1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ART1 (see all 6)
    OriGene ORF clones in mouse, rat for ART1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ART1 (NM_004314)
    Sino Biological Human cDNA Clone for ART1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ART1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ART1
    Sirion Biotech Customized lentivirus for stable overexpression of ART1 
                         Customized lentivirus expression plasmids for stable overexpression of ART1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ART1
    Search LifeMap BioReagents cell lines for ART1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ART1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ART1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Innate Immune System0.50
    2Beta defensins
    Defensins0.80
    3NAD metabolism
    NAD metabolism0.43
    4Alpha-defensins
    Alpha-defensins

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ART1
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for ART1
        NAD metabolism


    4        Reactome Pathways for ART1
        Defensins
    Alpha-defensins
    Immune System
    Innate Immune System



    ART1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ART1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ART1 (P529613 ENSP000002506934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDGFBP011273, ENSP000003303824I2D: score=1 STRING: ENSP00000330382
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006471protein ADP-ribosylation IEA--
    GO:0045087innate immune response TAS--

    ART1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ART1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ART1 (NAR1)

    5 HMDB Compounds for ART1    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--

    2 DrugBank Compounds for ART1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-Bromonicotinamide-- 28733-43-9target--17139284 17016423 10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235

    4 Novoseek inferred chemical compound relationships for ART1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpribose 84 1 11498506 (1)
    agmatine 74.1 2 11498506 (1)
    nad+ 63.3 2 10460751 (1), 11498506 (1)
    carbon 43 31 16453289 (6), 15078170 (4), 11587854 (3), 14563321 (2) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about ART1 / NAR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ART1 gene: 
    NM_004314.2  

    Unigene Cluster for ART1:

    ADP-ribosyltransferase 1
    Hs.382188
    Unigene Representative Sequence: NM_004314
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529556 ENST00000250693(uc009yeb.1 uc001lye.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ART1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ART1:
    hsa-miR-214 hsa-miR-629* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidART1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ART1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ART1
    Clone
    Products:
         
    OriGene clones in human, mouse for ART1 (see all 6)
    OriGene ORF clones in mouse, rat for ART1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ART1 (NM_004314)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ART1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ART1
    Sirion Biotech Customized lentivirus for stable overexpression of ART1 
                         Customized lentivirus expression plasmids for stable overexpression of ART1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ART1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ART1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ART1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ART1

    Additional mRNA sequence: 

    AJ291430.1 BC017828.1 BC069102.1 BC069828.1 BC111729.1 S74683.1 

    2 DOTS entries:

    DT.91749828  DT.91997175 

    7 AceView cDNA sequences:

    AJ291430 BC069828 BC069102 S74683 NM_004314 BC017828 BF790114 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ART1 expression in normal human tissues (normalized intensities)      ART1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCTTCAG
    ART1 Expression
    About this image


    ART1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 8 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
             limb/hindlimb   
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             visceral organ   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             cavities and their linings/intraembryonic coelom/diaphragm   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Retina
             sensory organ/eye/skeletal muscle   

    See ART1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ART1

    SOURCE GeneReport for Unigene cluster: Hs.382188
        SABiosciences Custom PCR Arrays for ART1
    Primer
    Products:
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ART1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ART1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ART1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Art11 , 5 ADP-ribosyltransferase 11, 5 81.09(n)1
    79.94(a)1
      7 (54.71 cM)5
    118701  NM_009710.41  NP_033840.21 
     1021017435 
    chicken
    (Gallus gallus)
    Aves --
    MADPRT6
    (see all 5)
    --
    erythroblast NAD(P)(+)--arginine ADP-ribosyltransf...
    (see all 5)
    45(a)
    44(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    1(193916659-193917770)
    1(193347495-193349021)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 7)
    --
    50(a)
    50(a)
    (see all 7)
    1 ↔ many
    1 ↔ many
    (see all 7)
    AAWZ02040529(65-2852)
    GL344444.1(28723-33060)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01019905.16
    CABZ01019905.36
    (see all 15)
    Uncharacterized protein
    (see all 15)
    35(a)
    31(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    3(7938826-7939488)
    3(7944095-7948418)


    ENSEMBL Gene Tree for ART1 (if available)
    TreeFam Gene Tree for ART1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ART1 gene
    ART42  ART52  ART32  
    3 SIMAP similar genes for ART1 using alignment to 1 protein entry:     NAR1_HUMAN:
    ART5    ART4    DO

    ART1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/730 SNPs in ART1 are shown (see all 730)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71237101,2
    C,F,H--3665604(+) AGGTCA/G/TGGGTG 1 -- us2k19NS NA WA 1260
    rs1491426411,2
    --3665649(+) GACCAC/GAGTAC 1 -- us2k10--------
    rs1809281581,2
    --3665761(+) TAGCAC/GGAAGA 1 -- us2k10--------
    rs1849985361,2
    C--3665915(+) GGTCCA/GCGTGA 1 -- us2k10--------
    rs1172933611,2
    C,F--3665934(+) TGATCG/AATTGA 1 -- us2k11Minor allele frequency- A:0.07EA 120
    rs1886859471,2
    C--3666033(+) TACAAA/TTAACC 1 -- us2k10--------
    rs1812383421,2
    --3666224(+) GCAGAA/GGCTGG 1 -- us2k10--------
    rs560063931,2
    C,F--3666277(+) GTGTCA/GCGTTT 1 -- us2k17Minor allele frequency- G:0.19NA CSA WA EA 364
    rs759239191,2
    F--3666307(+) AGGTTC/TAAGGG 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1123591291,2
    C,F--3666391(+) TTCCCC/TACCCA 1 -- ut511Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for ART1 (3666358 - 3685646 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for ART1 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744044CNV Deletion23290073
    esv2744046CNV Deletion23290073
    esv2744041CNV Deletion23290073
    esv2744043CNV Deletion23290073
    esv2744040CNV Deletion23290073
    esv2744039CNV Deletion23290073
    esv2744045CNV Deletion23290073
    nsv821603CNV Duplication20802225
    nsv509385CNV Insertion20534489
    esv995807CNV Loss20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601625    OMIM disorders: --

    6 diseases for ART1:    About MalaCards
    pertussis    cholera    squamous cell carcinoma of the head and neck    lymphopenia
    diphtheria    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for ART1:
    Cholera

    ART1 for disorders           About GeneDecksing


    Export disorders for ART1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ART1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with ART1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7. (PubMed id 8812442)1, 3 Koch-Nolte F....Thiele H.G. (1996)
    2. Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. (PubMed id 7947688)1, 2 Okazaki I.J.... Moss J. (1994)
    3. ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (PubMed id 16627471)1, 9 Paone G....Moss J. (2006)
    4. Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs. (PubMed id 10092875)1, 9 Kefalas P....MacDermot J. (1999)
    5. Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase. (PubMed id 11498506)1, 9 Saxty B.A....MacDermot J. (2001)
    6. Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase. (PubMed id 21901419)2 Dezelak M. and Bavec A. (2011)
    7. Toward a unified nomenclature for mammalian ADP- ribosyltransferases. (PubMed id 20106667)2 Hottiger M.O.... Koch-Nolte F. (2010)
    8. Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. (PubMed id 17614107)1 Li C....Wei Q. (2007)
    9. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 417 HGNC: 723 AceView: ART1 Ensembl:ENSG00000129744 euGenes: HUgn417
    ECgene: ART1 H-InvDB: ART1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ART1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ART1 gene:
    Search GeneIP for patents involving ART1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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