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Aliases for ART1 Gene

Aliases for ART1 Gene

  • ADP-Ribosyltransferase 1 2 3
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 1 3 4
  • Mono(ADP-Ribosyl)Transferase 1 3 4
  • ARTC1 3 4
  • ADP-Ribosyltransferase 2 3
  • CD296 Antigen 4
  • EC 4
  • CD296 3
  • ART2 3
  • RT6 3

External Ids for ART1 Gene

Previous GeneCards Identifiers for ART1 Gene

  • GC11P004241
  • GC11P003935
  • GC11P003625
  • GC11P003630
  • GC11P003622
  • GC11P003403

Summaries for ART1 Gene

Entrez Gene Summary for ART1 Gene

  • ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ART1 Gene

ART1 (ADP-Ribosyltransferase 1) is a Protein Coding gene. Among its related pathways are Immune System and NAD metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART4.

UniProtKB/Swiss-Prot for ART1 Gene

  • Has ADP-ribosyltransferase activity toward GLP1R.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART1 Gene

Genomics for ART1 Gene

Regulatory Elements for ART1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ART1 Gene

3,642,234 bp from pter
3,665,075 bp from pter
22,842 bases
Plus strand

Genomic View for ART1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ART1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART1 Gene

Proteins for ART1 Gene

  • Protein details for ART1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • Q6NTD2
    • Q96KT9

    Protein attributes for ART1 Gene

    327 amino acids
    Molecular mass:
    36335 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ART1 Gene

Proteomics data for ART1 Gene at MOPED

Post-translational modifications for ART1 Gene

  • Glycosylation at Asn 65 and Asn 253
  • Modification sites at PhosphoSitePlus

Other Protein References for ART1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ART1 Gene

Domains & Families for ART1 Gene

Gene Families for ART1 Gene

Protein Domains for ART1 Gene

Suggested Antigen Peptide Sequences for ART1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Arg-specific ADP-ribosyltransferase family.
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART1: view

Function for ART1 Gene

Molecular function for ART1 Gene

GENATLAS Biochemistry:
ADP ribosyltransferase 1,expressed in muscle
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
UniProtKB/Swiss-Prot Function:
Has ADP-ribosyltransferase activity toward GLP1R.

Enzyme Numbers (IUBMB) for ART1 Gene

Gene Ontology (GO) - Molecular Function for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
genes like me logo Genes that share ontologies with ART1: view

Phenotypes for ART1 Gene

GenomeRNAi human phenotypes for ART1:
genes like me logo Genes that share phenotypes with ART1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ART1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ART1 Gene

Localization for ART1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART1 Gene

Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for ART1 Gene COMPARTMENTS Subcellular localization image for ART1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
extracellular 1

Gene Ontology (GO) - Cellular Components for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7947688
GO:0009986 cell surface IEA --
GO:0031225 anchored component of membrane IEA --
GO:0033017 sarcoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with ART1: view

Pathways & Interactions for ART1 Gene

genes like me logo Genes that share pathways with ART1: view

Pathways by source for ART1 Gene

4 Reactome pathways for ART1 Gene
1 GeneGo (Thomson Reuters) pathway for ART1 Gene

Interacting Proteins for ART1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: P52961-NAR1_HUMAN ENSP00000250693 for ART1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with ART1: view

No data available for SIGNOR curated interactions for ART1 Gene

Drugs & Compounds for ART1 Gene

(6) Drugs for ART1 Gene - From: HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist 0
5-Bromonicotinamide Experimental Pharma Target 0
Nicotinamide Experimental Nutra 332,340
agmatine Experimental, Investigational Pharma Activator 0
NAD Pharma Agonist, Activator 0

(4) Additional Compounds for ART1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
genes like me logo Genes that share compounds with ART1: view

Transcripts for ART1 Gene

mRNA/cDNA for ART1 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ART1 Gene

ADP-ribosyltransferase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ART1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ART1 Gene

No ASD Table

Relevant External Links for ART1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ART1 Gene

mRNA expression in normal human tissues for ART1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART1 Gene

This gene is overexpressed in Muscle - Skeletal (x47.8).

SOURCE GeneReport for Unigene cluster for ART1 Gene Hs.382188

genes like me logo Genes that share expression patterns with ART1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ART1 Gene

Orthologs for ART1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ART1 35
  • 83.74 (n)
  • 77.61 (a)
-- 36
  • 84 (a)
ART1 36
  • 76 (a)
(Canis familiaris)
Mammalia ART1 35
  • 86.71 (n)
  • 86.29 (a)
ART1 36
  • 80 (a)
(Mus musculus)
Mammalia Art1 35
  • 81.68 (n)
  • 81.57 (a)
Art1 16
Art1 36
  • 77 (a)
(Pan troglodytes)
Mammalia ART1 35
  • 98.67 (n)
  • 98.78 (a)
ART1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Art1 35
  • 80.04 (n)
  • 80.25 (a)
(Monodelphis domestica)
Mammalia ART1 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia ART1 36
  • 58 (a)
(Gallus gallus)
Aves ART7B 35
  • 58.52 (n)
  • 50.76 (a)
-- 36
  • 45 (a)
ART1 36
  • 42 (a)
ART7B 36
  • 45 (a)
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
-- 36
  • 41 (a)
-- 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia art1 35
  • 55.31 (n)
  • 46.52 (a)
(Danio rerio)
Actinopterygii art4 36
  • 30 (a)
BX908804.1 36
  • 30 (a)
CABZ01019904.1 36
  • 26 (a)
CABZ01019905.1 36
  • 38 (a)
CABZ01019905.2 36
  • 32 (a)
CABZ01064699.1 36
  • 29 (a)
CR846080.3 36
  • 33 (a)
CR846080.4 36
  • 27 (a)
CR846080.5 36
  • 31 (a)
si:ch211-163m16.7 36
  • 26 (a)
si:ch211-51i16.1 36
  • 31 (a)
si:ch211-51i16.3 36
  • 33 (a)
si:ch73-379f5.5 36
  • 30 (a)
Species with no ortholog for ART1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART1 Gene

Gene Tree for ART1 (if available)
Gene Tree for ART1 (if available)

Paralogs for ART1 Gene

Paralogs for ART1 Gene

(3) SIMAP similar genes for ART1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ART1: view

Variants for ART1 Gene

Sequence variations from dbSNP and Humsavar for ART1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs149229160 -- 3,660,065(+) GTGCA(C/T)GGCCT reference, synonymous-codon
rs149222587 -- 3,654,504(+) CTGCC(A/G)TTCTC intron-variant
rs149142641 -- 3,644,419(+) GACCA(C/G)AGTAC upstream-variant-2KB, intron-variant
rs149037111 -- 3,654,965(+) CTGGC(C/T)CAGTG intron-variant
rs148871422 -- 3,653,896(+) CAAGT(A/C)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ART1 Gene

Variant ID Type Subtype PubMed ID
dgv336e1 CNV Complex 17122850
esv28322 CNV Gain+Loss 19812545
nsv832051 CNV Gain 17160897
essv2992 CNV CNV 17122850
dgv337e1 CNV Complex 17122850
nsv428247 CNV Loss 18775914
nsv832052 CNV Loss 17160897
nsv526441 CNV Gain 19592680
nsv509385 CNV Insertion 20534489
nsv8776 CNV Gain+Loss 18304495
nsv821603 CNV Duplication 20802225
esv2744039 CNV Deletion 23290073
esv995807 CNV Loss 20482838
esv2744040 CNV Deletion 23290073
esv2744041 CNV Deletion 23290073
esv2744043 CNV Deletion 23290073
esv2744044 CNV Deletion 23290073
esv2744045 CNV Deletion 23290073
esv2744046 CNV Deletion 23290073

Variation tolerance for ART1 Gene

Residual Variation Intolerance Score: 69.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ART1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART1 Gene

Disorders for ART1 Gene

Relevant External Links for ART1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ART1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ART1 Gene

Publications for ART1 Gene

  1. Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. (PMID: 20353610) Prasad P. … Thelma B.K. (BMC Med. Genet. 2010) 23 67
  2. Expression and selective up-regulation of toxin-related mono ADP-ribosyltransferases by pathogen-associated molecular patterns in alveolar epithelial cells. (PMID: 17707376) Balducci E. … Rappuoli R. (FEBS Lett. 2007) 23 67
  3. ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (PMID: 16627471) Paone G. … Moss J. (J. Biol. Chem. 2006) 23 67
  4. Substrate specificity of soluble and membrane-associated ADP-ribosyltransferase ART2.1. (PMID: 16453289) Zheng X. … Bortell R. (J. Cell. Biochem. 2006) 23 67
  5. Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation. (PMID: 16271711) Koch-Nolte F. … Haag F. (Cell. Immunol. 2005) 23 67

Products for ART1 Gene

Sources for ART1 Gene

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