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Aliases for ART1 Gene

Aliases for ART1 Gene

  • ADP-Ribosyltransferase 1 2 3 5
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 1 3 4
  • Mono(ADP-Ribosyl)Transferase 1 3 4
  • ARTC1 3 4
  • GPI-Linked NAD(P)(+)--Arginine ADP-Ribosyltransferase 1 3
  • ADP-Ribosyltransferase 2 3
  • CD296 Antigen 4
  • EC 4
  • CD296 3
  • ART2 3
  • RT6 3

External Ids for ART1 Gene

Previous GeneCards Identifiers for ART1 Gene

  • GC11P004241
  • GC11P003935
  • GC11P003625
  • GC11P003630
  • GC11P003622
  • GC11P003403

Summaries for ART1 Gene

Entrez Gene Summary for ART1 Gene

  • ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ART1 Gene

ART1 (ADP-Ribosyltransferase 1) is a Protein Coding gene. Among its related pathways are Immune System and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART5.

UniProtKB/Swiss-Prot for ART1 Gene

  • Has ADP-ribosyltransferase activity toward GLP1R.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART1 Gene

Genomics for ART1 Gene

Regulatory Elements for ART1 Gene

Enhancers for ART1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F003614 1.2 FANTOM5 Ensembl ENCODE 12.2 -27.4 -27355 1.8 BCOR SMARCE1 HDAC1 PKNOX1 ZMYM3 MAX ZIC2 RELA MBD2 GATA3 ART1 ART5 LOC101927708 NUP98 RHOG TRPC2
GH11F003830 1.5 FANTOM5 ENCODE 9.7 +194.1 194075 12.5 HDGF PKNOX1 ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RHOG NUP98 RRM1 TRIM68 ENSG00000206976 ART1 ART5 CHRNA10 STIM1 ENSG00000230593
GH11F003824 1.2 Ensembl ENCODE 9.7 +183.9 183922 3.2 HDGF HDAC1 PKNOX1 CBX3 ATF1 ARID4B NFXL1 RAD21 CBX5 GATA2 NUP98 ART1 ART5 CHRNA10 GC11P003826 GC11P003814
GH11F003339 1.1 Ensembl ENCODE 9.7 -302.0 -302042 1.6 HDAC1 CBX3 ESRRA ATF1 JUN RELA ZNF316 FOXK2 NCOR1 TRIM24 ZNF195 TSSC2 ENSG00000224513 MRGPRG MRGPRG-AS1 RNU1-91P NAP1L4 SNORA54 ART1 ART5
GH11F003444 0.9 Ensembl 11.1 -198.0 -198034 0.4 HDGF HDAC1 CBX3 PKNOX1 ATF1 ARNT FEZF1 CHAMP1 EGR2 ZEB2 ART1 ART5 LOC105376525 GC11P003434
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ART1 on UCSC Golden Path with GeneCards custom track

Promoters for ART1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000684709 66 1001 CREB3L1 ARID4B ZNF48 GLIS2 GATA2 SP3 SP5 JUNB KAT8 MEF2D

Genomic Location for ART1 Gene

3,642,234 bp from pter
3,665,075 bp from pter
22,842 bases
Plus strand

Genomic View for ART1 Gene

Genes around ART1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ART1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ART1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART1 Gene

Proteins for ART1 Gene

  • Protein details for ART1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
    Protein Accession:
    Secondary Accessions:
    • Q6NTD2
    • Q96KT9

    Protein attributes for ART1 Gene

    327 amino acids
    Molecular mass:
    36335 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ART1 Gene

Post-translational modifications for ART1 Gene

  • Glycosylation at Asn 65 and Asn 253
  • Modification sites at PhosphoSitePlus

Other Protein References for ART1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ART1 Gene

Domains & Families for ART1 Gene

Gene Families for ART1 Gene

Protein Domains for ART1 Gene

Suggested Antigen Peptide Sequences for ART1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Arg-specific ADP-ribosyltransferase family.
  • Belongs to the Arg-specific ADP-ribosyltransferase family.
genes like me logo Genes that share domains with ART1: view

Function for ART1 Gene

Molecular function for ART1 Gene

GENATLAS Biochemistry:
ADP ribosyltransferase 1,expressed in muscle
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.
UniProtKB/Swiss-Prot Function:
Has ADP-ribosyltransferase activity toward GLP1R.

Enzyme Numbers (IUBMB) for ART1 Gene

Gene Ontology (GO) - Molecular Function for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with ART1: view
genes like me logo Genes that share phenotypes with ART1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ART1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ART1 Gene

Localization for ART1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART1 Gene

Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ART1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
extracellular 3
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7947688
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with ART1: view

Pathways & Interactions for ART1 Gene

genes like me logo Genes that share pathways with ART1: view

Pathways by source for ART1 Gene

4 Reactome pathways for ART1 Gene
1 GeneGo (Thomson Reuters) pathway for ART1 Gene

Interacting Proteins for ART1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000250693 P52961-NAR1_HUMAN for ART1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA,TAS --
genes like me logo Genes that share ontologies with ART1: view

No data available for SIGNOR curated interactions for ART1 Gene

Drugs & Compounds for ART1 Gene

(6) Drugs for ART1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Arginine Approved Nutra Full agonist, Agonist 0
Nicotinamide Approved Nutra 902,906
5-Bromonicotinamide Experimental Pharma Target 0
NAD Pharma Full agonist, Agonist 0
NADH Nutra 0

(4) Additional Compounds for ART1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
genes like me logo Genes that share compounds with ART1: view

Transcripts for ART1 Gene

mRNA/cDNA for ART1 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ART1 Gene

ADP-ribosyltransferase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ART1 Gene

No ASD Table

Relevant External Links for ART1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ART1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ART1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART1 Gene

This gene is overexpressed in Muscle - Skeletal (x47.8).

NURSA nuclear receptor signaling pathways regulating expression of ART1 Gene:


SOURCE GeneReport for Unigene cluster for ART1 Gene:

genes like me logo Genes that share expression patterns with ART1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ART1 Gene

Orthologs for ART1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ART1 34 35
  • 98.67 (n)
(Canis familiaris)
Mammalia ART1 34 35
  • 86.71 (n)
(Bos Taurus)
Mammalia -- 35
  • 84 (a)
ART1 34 35
  • 83.74 (n)
(Mus musculus)
Mammalia Art1 34 16 35
  • 81.68 (n)
(Rattus norvegicus)
Mammalia Art1 34
  • 80.04 (n)
(Monodelphis domestica)
Mammalia ART1 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia ART1 35
  • 58 (a)
(Gallus gallus)
Aves ART7B 34 35
  • 58.52 (n)
-- 35
  • 45 (a)
  • 45 (a)
ART1 35
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
-- 35
  • 48 (a)
-- 35
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia art1 34
  • 55.31 (n)
(Danio rerio)
Actinopterygii CABZ01019905.1 35
  • 38 (a)
CR846080.3 35
  • 33 (a)
si:ch211-51i16.3 35
  • 33 (a)
CABZ01019905.2 35
  • 32 (a)
CR846080.5 35
  • 31 (a)
si:ch211-51i16.1 35
  • 31 (a)
art4 35
  • 30 (a)
BX908804.1 35
  • 30 (a)
si:ch73-379f5.5 35
  • 30 (a)
CABZ01064699.1 35
  • 29 (a)
CR846080.4 35
  • 27 (a)
CABZ01019904.1 35
  • 26 (a)
si:ch211-163m16.7 35
  • 26 (a)
Species where no ortholog for ART1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART1 Gene

Gene Tree for ART1 (if available)
Gene Tree for ART1 (if available)

Paralogs for ART1 Gene

Paralogs for ART1 Gene

(3) SIMAP similar genes for ART1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ART1: view

Variants for ART1 Gene

Sequence variations from dbSNP and Humsavar for ART1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10767394 -- 3,643,526(+) AAAAA(A/G)AAAAA upstream-variant-2KB
rs10767404 -- 3,648,285(+) GTGGT(C/G)TCTTC intron-variant
rs10834744 -- 3,660,620(+) AACGC(A/G)GCGGT intron-variant
rs10834761 -- 3,664,991(+) AGTCC(C/T)GAGGC utr-variant-3-prime
rs11028736 -- 3,644,054(+) tggca(A/G)gcgcc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ART1 Gene

Variant ID Type Subtype PubMed ID
dgv1580n54 CNV loss 21841781
dgv1581n54 CNV loss 21841781
dgv555e59 CNV duplication 20981092
dgv577n106 CNV tandem duplication 24896259
esv2744039 CNV deletion 23290073
esv2744040 CNV deletion 23290073
esv2744041 CNV deletion 23290073
esv2744043 CNV deletion 23290073
esv2744044 CNV deletion 23290073
esv2744045 CNV deletion 23290073
esv2744046 CNV deletion 23290073
esv2759796 CNV gain+loss 17122850
esv2760179 CNV loss 21179565
esv2760300 CNV gain 21179565
esv28322 CNV gain+loss 19812545
esv3625147 CNV gain 21293372
esv3625148 CNV gain 21293372
esv995807 CNV loss 20482838
nsv1046356 CNV gain 25217958
nsv1134083 CNV deletion 24896259
nsv428247 CNV loss 18775914
nsv509385 CNV insertion 20534489
nsv526441 CNV gain 19592680
nsv553142 CNV loss 21841781
nsv553150 CNV loss 21841781
nsv821603 CNV duplication 20802225
nsv832051 CNV gain 17160897
nsv832052 CNV loss 17160897
nsv8776 CNV gain+loss 18304495

Variation tolerance for ART1 Gene

Residual Variation Intolerance Score: 69.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ART1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART1 Gene

Disorders for ART1 Gene

Relevant External Links for ART1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ART1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ART1 Gene

Publications for ART1 Gene

  1. ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (PMID: 16627471) Paone G. … Moss J. (J. Biol. Chem. 2006) 3 22 64
  2. Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase. (PMID: 11498506) Saxty B.A. … MacDermot J. (Br. J. Pharmacol. 2001) 3 22 64
  3. Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs. (PMID: 10092875) Kefalas P. … MacDermot J. (Eur. J. Biochem. 1999) 3 22 64
  4. Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7. (PMID: 8812442) Koch-Nolte F. … Thiele H.G. (Genomics 1996) 2 3 64
  5. Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. (PMID: 7947688) Okazaki I.J. … Moss J. (Biochemistry 1994) 3 4 64

Products for ART1 Gene

Sources for ART1 Gene

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