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ART1 Gene

protein-coding   GIFtS: 62
GCID: GC11P003666

ADP-Ribosyltransferase 1

  See ART1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
ADP-Ribosyltransferase 11 2     RT62
Mono(ADP-Ribosyl)Transferase 12 3     ADP-Ribosyltransferase 22
ARTC12 3     GPI-Linked NAD(P)(+)--Arginine ADP-Ribosyltransferase 12
ADP-Ribosyltransferase C2 And C3 Toxin-Like 12 3     EC 2.4.2.313
ART22     CD296 Antigen3
CD2962     

External Ids:    HGNC: 7231   Entrez Gene: 4172   Ensembl: ENSG000001297447   OMIM: 6016255   UniProtKB: P529613   
ORGUL members:         

Export aliases for ART1 gene to outside databases

Previous GC identifers: GC11P004241 GC11P003935 GC11P003625 GC11P003630 GC11P003622 GC11P003403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ART1 Gene:
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a
posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including
cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly
hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored
proteins. This gene was previously designated ART2. (provided by RefSeq, Jul 2008)

GeneCards Summary for ART1 Gene:
ART1 (ADP-ribosyltransferase 1) is a protein-coding gene. Diseases associated with ART1 include pertussis, and cholera. GO annotations related to this gene include NAD(P)+-protein-arginine ADP-ribosyltransferase activity and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is ART4.

UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961
Function: Has ADP-ribosyltransferase activity toward GLP1R




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ART1 gene promoter:
         SRF   E2F-4   E2F-3a   E2F-5   FOXF2   SRF (504 AA)   E2F-2   E2F-1   E2F   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidART1 promoter sequence
   Search Chromatin IP Primers for ART1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ART1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

ART1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ART1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P003666:  view genomic region     (about GC identifiers)

Start:
3,666,358 bp from pter      End:
3,685,646 bp from pter
Size:
19,289 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961 (See protein sequence)
Recommended Name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor  
Size: 327 amino acids; 36335 Da
Secondary accessions: Q6NTD2 Q96KT9

Explore the universe of human proteins at neXtProt for ART1: NX_P52961

Explore proteomics data for ART1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn253
  • Modification sites at PhosphoSitePlus

  • See ART1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004305.2  
    ENSEMBL proteins: 
     ENSP00000250693  
    Reactome Protein details: P52961

    ART1 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ART1

     
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    antibodies-online proteins for ART1 

     
    antibodies-online peptides for ART1

    ART1 Antibody Products:

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    antibodies-online antibodies for ART1 (20 products) 

    ART1 Assay Products:

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    antibodies-online kits for ART1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    1 InterPro protein domain:
     IPR000768 ART

    Graphical View of Domain Structure for InterPro Entry P52961

    ProtoNet protein and cluster: P52961

    1 Blocks protein domain: IPB000768 NAD:arginine ADP-ribosyltransferase

    UniProtKB/Swiss-Prot: NAR1_HUMAN, P52961
    Similarity: Belongs to the Arg-specific ADP-ribosyltransferase family


    Find genes that share domains with ART1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAR1_HUMAN, P52961
    Function: Has ADP-ribosyltransferase activity toward GLP1R
    Catalytic activity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine

         Genatlas biochemistry entry for ART1:
    ADP ribosyltransferase 1,expressed in muscle

         Enzyme Number (IUBMB): EC 2.4.2.311

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity IEA--
    GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA--
         
    Find genes that share ontologies with ART1           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Art1 (no phenotypes)

    Find genes that share phenotypes with ART1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Art1tm1Lex for ART1

       genOway: Develop your customized and physiologically relevant rodent model for ART1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ART1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ART1:
    hsa-miR-214 hsa-miR-629* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidART1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ART1
    Predesigned siRNA for gene silencing in human, mouse, rat ART1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ART1 (see all 6)
    OriGene ORF clones in mouse, rat for ART1
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    GenScript: all cDNA clones in your preferred vector: ART1 (NM_004314)
    Sino Biological Human cDNA Clone for ART1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ART1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ART1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ART1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAR1_HUMAN, P52961: Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane4
    extracellular2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7947688
    GO:0009986cell surface IEA--
    GO:0031225anchored component of membrane IEA--
    GO:0033017sarcoplasmic reticulum membrane IEA--

    Find genes that share ontologies with ART1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ART1 About    
    See pathways by source

    SuperPathContained pathways About
    1Defensins
    Defensins0.80
    Alpha-defensins0.00
    2Nicotinate and nicotinamide metabolism
    NAD metabolism0.43


    Find genes that share SuperPaths with ART1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ART1
        NAD metabolism


    1 Reactome Pathway for ART1
        Alpha-defensins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ART1
    Interactions:

        Search GeneGlobe Interaction Network for ART1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ART1 (P529613 ENSP000002506934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDGFBP011273, ENSP000003303824I2D: score=1 STRING: ENSP00000330382
    H2AFXENSP000003643104STRING: ENSP00000364310
    TAL1ENSP000002943394STRING: ENSP00000294339
    H2AFJENSP000003737304STRING: ENSP00000373730
    HIST2H2ABENSP000003327904STRING: ENSP00000332790
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006471protein ADP-ribosylation IEA--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with ART1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ART1 (NAR1)

    5 HMDB Compounds for ART1    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--

    2 DrugBank Compounds for ART1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-Bromonicotinamide-- 28733-43-9target--17139284 17016423 10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235

    4 Novoseek inferred chemical compound relationships for ART1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpribose 84 1 11498506 (1)
    agmatine 74.1 2 11498506 (1)
    nad+ 63.3 2 10460751 (1), 11498506 (1)
    carbon 43 31 16453289 (6), 15078170 (4), 11587854 (3), 14563321 (2) (see all 7)



    Find genes that share compounds with ART1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ART1 gene: 
    NM_004314.2  

    Unigene Cluster for ART1:

    ADP-ribosyltransferase 1
    Hs.382188
    Unigene Representative Sequence: NM_004314
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529556 ENST00000250693(uc009yeb.1 uc001lye.1)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate ART1:
    hsa-miR-214 hsa-miR-629* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidART1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ART1
    Predesigned siRNA for gene silencing in human, mouse, rat ART1
    Clone
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    GenScript: all cDNA clones in your preferred vector: ART1 (NM_004314)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ART1
      QuantiTect SYBR Green Assays in human, mouse, rat ART1
      QuantiFast Probe-based Assays in human, mouse, rat ART1

    Additional mRNA sequence: 

    AJ291430.1 BC017828.1 BC069102.1 BC069828.1 BC111729.1 S74683.1 

    2 DOTS entries:

    DT.91749828  DT.91997175 

    7 AceView cDNA sequences:

    AJ291430 BC069828 BC069102 NM_004314 S74683 BC017828 BF790114 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ART1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGCTTCAG
    ART1 Expression
    About this image


    ART1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
    ART1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ART1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.382188
        Custom PCR Arrays for ART1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ART1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Art11 , 5 ADP-ribosyltransferase 11, 5 81.68(n)1
    81.57(a)1
      7 (54.71 cM)5
    118701  NM_009710.41  NP_033840.21 
     1021017435 
    chicken
    (Gallus gallus)
    Aves ART7B1 GPI-anchored ADP-ribosyltransferase 58.52(n)
    50.76(a)
      428124  NM_001114504.1  NP_001107976.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    48(a)
    48(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL344444.1(28723-33060)
    AAWZ02040529(65-2852)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia art11 ADP-ribosyltransferase 1 55.31(n)
    46.52(a)
      780139  NM_001079214.1  NP_001072682.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01019905.16
    si:ch211-51i16.36
    (see all 13)
    si:ch211-51i16.3
    (see all 13)
    38(a)
    33(a)
    (see all 13)
    many ↔ many
    many ↔ many
    (see all 13)
    3(7938826-7939488) ENSDARG00000040229
    3(7944095-7952874) ENSDARG00000091149


    ENSEMBL Gene Tree for ART1 (if available)
    TreeFam Gene Tree for ART1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ART1 gene
    ART42  ART52  ART32  
    3 SIMAP similar genes for ART1 using alignment to 1 protein entry:     NAR1_HUMAN:
    ART5    ART4    DO

    Find genes that share paralogs with ART1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ART1 (see all 730)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71237101,2
    C,F,H--3665604(+) AGGTCA/G/TGGGTG 1 -- us2k19NS NA WA 1260
    rs1491426411,2
    --3665649(+) GACCAC/GAGTAC 1 -- us2k10--------
    rs1809281581,2
    --3665761(+) TAGCAC/GGAAGA 1 -- us2k10--------
    rs1849985361,2
    C--3665915(+) GGTCCA/GCGTGA 1 -- us2k10--------
    rs1172933611,2
    C,F--3665934(+) TGATCG/AATTGA 1 -- us2k11Minor allele frequency- A:0.07EA 120
    rs1886859471,2
    C--3666033(+) TACAAA/TTAACC 1 -- us2k10--------
    rs1812383421,2
    --3666224(+) GCAGAA/GGCTGG 1 -- us2k10--------
    rs560063931,2
    C,F--3666277(+) GTGTCA/GCGTTT 1 -- us2k17Minor allele frequency- G:0.19NA CSA WA EA 364
    rs759239191,2
    F--3666307(+) AGGTTC/TAAGGG 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1123591291,2
    C,F--3666391(+) TTCCCC/TACCCA 1 -- ut511Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for ART1 (3666358 - 3685646 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ART1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744044CNV Deletion23290073
    esv2744046CNV Deletion23290073
    esv2744041CNV Deletion23290073
    esv2744043CNV Deletion23290073
    esv2744040CNV Deletion23290073
    esv2744039CNV Deletion23290073
    esv2744045CNV Deletion23290073
    nsv821603CNV Duplication20802225
    nsv509385CNV Insertion20534489
    esv995807CNV Loss20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601625    OMIM disorders: --

    3 diseases for ART1:    
    About MalaCards
    pertussis    cholera    squamous cell carcinoma of the head and neck

    1 disease from the University of Copenhagen DISEASES database for ART1:
    Cholera

    Find genes that share disorders with ART1           About GenesLikeMe


    Export disorders for ART1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ART1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with ART1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7. (PubMed id 8812442)1, 3 Koch-Nolte F....Thiele H.G. (Genomics 1996)
    2. Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. (PubMed id 7947688)1, 2 Okazaki I.J.... Moss J. (Biochemistry 1994)
    3. ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (PubMed id 16627471)1, 9 Paone G....Moss J. (J. Biol. Chem. 2006)
    4. Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs. (PubMed id 10092875)1, 9 Kefalas P....MacDermot J. (Eur. J. Biochem. 1999)
    5. Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase. (PubMed id 11498506)1, 9 Saxty B.A....MacDermot J. (Br. J. Pharmacol. 2001)
    6. Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase. (PubMed id 21901419)2 Dezelak M. and Bavec A. (Mol. Biol. Rep. 2012)
    7. Toward a unified nomenclature for mammalian ADP- ribosyltransferases. (PubMed id 20106667)2 Hottiger M.O.... Koch-Nolte F. (Trends Biochem. Sci. 2010)
    8. Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck. (PubMed id 17614107)1 Li C....Wei Q. (Cancer 2007)
    9. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 417 HGNC: 723 AceView: ART1 Ensembl:ENSG00000129744 euGenes: HUgn417
    ECgene: ART1 H-InvDB: ART1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ART1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ART1 gene:
    Search GeneIP for patents involving ART1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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