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Aliases for ART1 Gene

Aliases for ART1 Gene

  • ADP-Ribosyltransferase 1 2 3
  • ADP-Ribosyltransferase C2 And C3 Toxin-Like 1 3 4
  • Mono(ADP-Ribosyl)Transferase 1 3 4
  • ARTC1 3 4
  • GPI-Linked NAD(P)(+)--Arginine ADP-Ribosyltransferase 1 3
  • ADP-Ribosyltransferase 2 3
  • CD296 Antigen 4
  • EC 2.4.2.31 4
  • CD296 3
  • ART2 3
  • RT6 3

External Ids for ART1 Gene

Summaries for ART1 Gene

Entrez Gene Summary for ART1 Gene

  • ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ART1 Gene

ART1 (ADP-Ribosyltransferase 1) is a Protein Coding gene. Diseases associated with ART1 include pertussis and cholera. Among its related pathways are Nicotinate and nicotinamide metabolism and Defensins. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD(P)+-protein-arginine ADP-ribosyltransferase activity. An important paralog of this gene is ART4.

UniProtKB/Swiss-Prot for ART1 Gene

  • Has ADP-ribosyltransferase activity toward GLP1R.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ART1 Gene

Genomics for ART1 Gene

Genomic Location for ART1 Gene

Start:
3,645,128 bp from pter
End:
3,684,772 bp from pter
Size:
39,645 bases
Orientation:
Plus strand

Genomic View for ART1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ART1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ART1 Gene

Regulatory Elements for ART1 Gene

Proteins for ART1 Gene

  • Protein details for ART1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52961-NAR1_HUMAN
    Recommended name:
    GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
    Protein Accession:
    P52961
    Secondary Accessions:
    • Q6NTD2
    • Q96KT9

    Protein attributes for ART1 Gene

    Size:
    327 amino acids
    Molecular mass:
    36335 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ART1 Gene

Proteomics data for ART1 Gene at MOPED

Post-translational modifications for ART1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn65 and Asn253

Other Protein References for ART1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ART1 Gene

Domains for ART1 Gene

Gene Families for ART1 Gene

HGNC:
  • CD :CD molecules

Protein Domains for ART1 Gene

Suggested Antigen Peptide Sequences for ART1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52961

UniProtKB/Swiss-Prot:

NAR1_HUMAN
Family:
  • Belongs to the Arg-specific ADP-ribosyltransferase family.:
    • P52961
genes like me logo Genes that share domains with ART1: view

Function for ART1 Gene

Molecular function for ART1 Gene

GENATLAS Biochemistry: ADP ribosyltransferase 1,expressed in muscle
UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
UniProtKB/Swiss-Prot Function: Has ADP-ribosyltransferase activity toward GLP1R.

Enzyme Numbers (IUBMB) for ART1 Gene

Gene Ontology (GO) - Molecular Function for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA --
genes like me logo Genes that share ontologies with ART1: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ART1 Gene

Localization for ART1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ART1 Gene

Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ART1 Gene COMPARTMENTS Subcellular localization image for ART1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
extracellular 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7947688
GO:0009986 cell surface IEA --
GO:0016529 sarcoplasmic reticulum --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with ART1: view

Pathways for ART1 Gene

genes like me logo Genes that share pathways with ART1: view

Pathways by source for ART1 Gene

1 GeneGo (Thomson Reuters) pathway for ART1 Gene
2 Reactome pathways for ART1 Gene

Interacting Proteins for ART1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000250693%0d%0a9606.ENSP00000330382%0d%0a
Selected Interacting proteins: ENSP00000250693 P52961-NAR1_HUMAN for ART1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ART1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 protein ADP-ribosylation IEA --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with ART1: view

Compounds for ART1 Gene

(5) HMDB Compounds for ART1 Gene

Compound Synonyms Cas Number PubMed IDs
L-Arginine
  • (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate
74-79-3
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
Niacinamide
  • 3-Carbamoylpyridine
98-92-0

(2) Drugbank Compounds for ART1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
5-Bromonicotinamide
28733-43-9 target
Nicotinamide-Adenine-Dinucleotide
53-84-9 target

(4) Novoseek inferred chemical compound relationships for ART1 Gene

Compound -log(P) Hits PubMed IDs
adpribose 84 1
agmatine 74.1 1
nad+ 63.3 2
carbon 43 18
genes like me logo Genes that share compounds with ART1: view

Transcripts for ART1 Gene

mRNA/cDNA for ART1 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ART1 Gene

ADP-ribosyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ART1 Gene

No ASD Table

Relevant External Links for ART1 Gene

GeneLoc Exon Structure for
ART1
ECgene alternative splicing isoforms for
ART1

Expression for ART1 Gene

mRNA expression in normal human tissues for ART1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ART1 Gene

This gene is overexpressed in Muscle - Skeletal (47.8).

SOURCE GeneReport for Unigene cluster for ART1 Gene Hs.382188

genes like me logo Genes that share expressions with ART1: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for ART1 Gene

Orthologs for ART1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ART1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ART1 35
  • 98.67 (n)
  • 98.78 (a)
ART1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 84 (a)
OneToMany
ART1 35
  • 83.74 (n)
  • 77.61 (a)
ART1 36
  • 76 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ART1 35
  • 86.71 (n)
  • 86.29 (a)
ART1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Art1 35
  • 81.68 (n)
  • 81.57 (a)
Art1 16
Art1 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ART1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ART1 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Art1 35
  • 80.04 (n)
  • 80.25 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
ART1 36
  • 42 (a)
OneToMany
ART7B 35
  • 58.52 (n)
  • 50.76 (a)
ART7B 36
  • 45 (a)
OneToMany
MADPRT 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia art1 35
  • 55.31 (n)
  • 46.52 (a)
zebrafish
(Danio rerio)
Actinopterygii art4 36
  • 30 (a)
ManyToMany
BX908804.1 36
  • 30 (a)
ManyToMany
CABZ01019904.1 36
  • 26 (a)
ManyToMany
CABZ01019905.1 36
  • 38 (a)
ManyToMany
CABZ01019905.2 36
  • 32 (a)
ManyToMany
CABZ01064699.1 36
  • 29 (a)
ManyToMany
CR846080.3 36
  • 33 (a)
ManyToMany
CR846080.4 36
  • 27 (a)
ManyToMany
CR846080.5 36
  • 31 (a)
ManyToMany
si:ch211-163m16.7 36
  • 26 (a)
ManyToMany
si:ch211-51i16.1 36
  • 31 (a)
ManyToMany
si:ch211-51i16.3 36
  • 33 (a)
ManyToMany
si:ch73-379f5.5 36
  • 30 (a)
ManyToMany
Species with no ortholog for ART1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ART1 Gene

ENSEMBL:
Gene Tree for ART1 (if available)
TreeFam:
Gene Tree for ART1 (if available)

Paralogs for ART1 Gene

Paralogs for ART1 Gene

Selected SIMAP similar genes for ART1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ART1: view

Variants for ART1 Gene

Sequence variations from dbSNP and Humsavar for ART1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs925696 -- 3,658,428(+) CACTT(C/T)GGGCA intron-variant
rs925697 -- 3,658,581(+) GGAAG(C/T)ACCGA intron-variant
rs2048730 -- 3,653,645(+) GAGGA(A/G)CTTCG intron-variant, upstream-variant-2KB
rs2271582 -- 3,664,213(+) GCCTC(A/G)CCTGC utr-variant-3-prime, intron-variant
rs2271583 -- 3,664,425(+) GTGGC(A/G)GGTAC downstream-variant-500B, intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ART1 Gene

Variant ID Type Subtype PubMed ID
dgv336e1 CNV Complex 17122850
esv28322 CNV Gain+Loss 19812545
nsv832051 CNV Gain 17160897
essv2992 CNV CNV 17122850
dgv337e1 CNV Complex 17122850
nsv428247 CNV Loss 18775914
nsv832052 CNV Loss 17160897
nsv526441 CNV Gain 19592680
nsv509385 CNV Insertion 20534489
nsv8776 CNV Gain+Loss 18304495
nsv821603 CNV Duplication 20802225
esv2744039 CNV Deletion 23290073
esv995807 CNV Loss 20482838
esv2744040 CNV Deletion 23290073
esv2744041 CNV Deletion 23290073
esv2744043 CNV Deletion 23290073
esv2744044 CNV Deletion 23290073
esv2744045 CNV Deletion 23290073
esv2744046 CNV Deletion 23290073

Relevant External Links for ART1 Gene

HapMap Linkage Disequilibrium report
ART1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ART1 Gene

Disorders for ART1 Gene

(2) MalaCards Diseases for ART1 Gene

Search for ART1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ART1 Gene

genes like me logo Genes that share disorders with ART1: view

No data available for UniProtKB/Swiss-Prot for ART1 Gene

Publications for ART1 Gene

  1. Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs. (PMID: 10092875) Kefalas P. … MacDermot J. (Eur. J. Biochem. 1999) 3 23
  2. Inactivation of platelet-derived growth factor-BB following modification by ADP-ribosyltransferase. (PMID: 11498506) Saxty B.A. … MacDermot J. (Br. J. Pharmacol. 2001) 3 23
  3. Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. (PMID: 7947688) Okazaki I.J. … Moss J. (Biochemistry 1994) 3 4
  4. Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7. (PMID: 8812442) Koch-Nolte F. … Thiele H.G. (Genomics 1996) 2 3
  5. ADP-ribosyltransferase-specific modification of human neutrophil peptide-1. (PMID: 16627471) Paone G. … Moss J. (J. Biol. Chem. 2006) 3 23

Products for ART1 Gene

Sources for ART1 Gene

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