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ARSK Gene

protein-coding   GIFtS: 52
GCID: GC05P094917

Arylsulfatase Family, Member K

(Previous name: arylsulfatase K)
  Search for ARSK
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arylsulfatase Family, Member K1 2     TSULF2 3
Arylsulfatase K1 2     EC 3.1.6.-3
Telethon Sulfatase2 3     EC 3.1.68
ASK2 3     

External Ids:    HGNC: 252391   Entrez Gene: 1536422   Ensembl: ENSG000001642917   OMIM: 6100115   UniProtKB: Q6UWY03   

Export aliases for ARSK gene to outside databases

Previous GC identifer: GC05P090081


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARSK Gene:
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates,
proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and
degradation of macromolecules (Sardiello et al., 2005 (PubMed 16174644)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ARSK Gene:
ARSK (arylsulfatase family, member K) is a protein-coding gene. GO annotations related to this gene include arylsulfatase activity. An important paralog of this gene is ENSG00000241489.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARSK gene promoter:
         E2F-4   TBP   E2F-5   GATA-3   Lmo2   GATA-1   GATA-2   PPAR-alpha   HFH-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARSK promoter sequence
   Search Chromatin IP Primers for ARSK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARSK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

ARSK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARSK gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P094917:  view genomic region     (about GC identifiers)

Start:
94,890,778 bp from pter      End:
94,940,806 bp from pter
Size:
50,029 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARSK_HUMAN, Q6UWY0 (See protein sequence)
Recommended Name: Arylsulfatase K precursor  
Size: 536 amino acids; 61450 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Sequence caution: Sequence=AAH36047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2BDE3 B4E1I4 Q3ZCW3 Q8N3Q8

Explore the universe of human proteins at neXtProt for ARSK: NX_Q6UWY0

Explore proteomics data for ARSK at MOPED

Post-translational modifications: 

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
  • Glycosylation2 at Asn108, Asn166, Asn193, Asn262, Asn375, Asn413, Asn498
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ARSK (Q6UWY0) (see all 17)
     DPDELTN  YNKEQFI  YYAMCAE  NASTYML 


    See ARSK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_937793.1  
    ENSEMBL proteins: 
     ENSP00000369346   ENSP00000422608   ENSP00000422126   ENSP00000423636   ENSP00000424018  
    Reactome Protein details: Q6UWY0

    ARSK Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ARSK
    OriGene Custom MassSpec
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    Novus Biologicals ARSK Protein
    Novus Biologicals ARSK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARSK

    ARSK Antibody Products:

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    Abcam antibodies for ARSK
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    Search ThermoFisher Antibodies for ARSK
    LSBio Antibodies in human, mouse, rat for ARSK

    ARSK Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARSK
    Cloud-Clone Corp. CLIAs for ARSK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARS: Arylsulfatase family

    3 InterPro protein domains:
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR000917 Sulfatase
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q6UWY0

    ProtoNet protein and cluster: Q6UWY0

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: ARSK_HUMAN, Q6UWY0
    Similarity: Belongs to the sulfatase family


    ARSK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.62

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004065arylsulfatase activity TAS16174644
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    ARSK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARSK:
     Increased S DNA content 

         1 MGI phenotypic allele for Arsk (no phenotypes)

    ARSK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARSK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARSK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARSK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARSK

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ARSK using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ARSK:
    hsa-miR-2116*
    SwitchGear 3'UTR luciferase reporter plasmidARSK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARSK
    Predesigned siRNA for gene silencing in human, mouse, rat ARSK

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ARSK (NM_198150)
    Sino Biological Human cDNA Clone for ARSK
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSK

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ARSK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARSK_HUMAN, Q6UWY0: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    extracellular3
    golgi apparatus1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005788endoplasmic reticulum lumen TAS--

    ARSK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARSK About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Glycosphingolipid metabolism0.56
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    The activation of arylsulfatases0.00
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for ARSK
        Glycosphingolipid metabolism
    The activation of arylsulfatases



    ARSK for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARSK
    Interactions:

        Search GeneGlobe Interaction Network for ARSK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ARSK (ENSP000003693464) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSAENSP000002161244STRING: ENSP00000216124
    ARSBENSP000002649144STRING: ENSP00000264914
    ARSDENSP000003705464STRING: ENSP00000370546
    ARSEENSP000003705264STRING: ENSP00000370526
    ARSFENSP000003523194STRING: ENSP00000352319
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    ARSK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARSK

    1 HMDB Compound for ARSK    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARSK gene: 
    NM_198150.2  

    Unigene Cluster for ARSK:

    Arylsulfatase family, member K
    Hs.585051  [show with all ESTs]
    Unigene Representative Sequence: NM_198150
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380009(uc003kld.3 uc010jbg.3 uc011cum.2) ENST00000513814
    ENST00000504763(uc003klc.3) ENST00000504873 ENST00000512106
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARSK using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ARSK:
    hsa-miR-2116*
    SwitchGear 3'UTR luciferase reporter plasmidARSK 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARSK
    Predesigned siRNA for gene silencing in human, mouse, rat ARSK
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARSK (NM_198150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSK
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ARSK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARSK
      QuantiTect SYBR Green Assays in human, mouse, rat ARSK
      QuantiFast Probe-based Assays in human, mouse, rat ARSK

    Additional mRNA sequence: 

    AK303855.1 AK316253.1 AL832711.1 AY358596.1 AY875939.1 BC015723.2 BC036047.1 BC050392.1 
    BC080567.1 BC130329.1 BC144160.1 BC144161.1 

    4 DOTS entries:

    DT.40238437  DT.428830  DT.97832036  DT.97832037 

    Selected AceView cDNA sequences (see all 57):

    AW069167 BC050392 AA314107 BC080567 AA565548 BM923547 BF478009 AA548225 
    BU630043 NM_198150 CA397780 BX109484 CA442752 BU527024 AI421965 BE295686 
    AY358596 AA883670 AI243677 BE891525 BG428776 AV702415 BM835092 BC015723 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARSK    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                          -                                                               
    SP2:                          -                 -                                             
    SP3:                          -           -     -                                             
    SP4:                                                                                          


    ECgene alternative splicing isoforms for ARSK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARSK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCTTCTTT
    ARSK Expression
    About this image

    ARSK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARSK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585051
        Custom PCR Arrays for ARSK
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARSK gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arsk1 , 5 arylsulfatase K1, 5 83.8(n)1
    82.55(a)1
      13 (40.95 cM)5
    770411  NM_029847.41  NP_084123.21 
     760604225 
    chicken
    (Gallus gallus)
    Aves ARSK1 arylsulfatase family, member K 74.98(n)
    76.45(a)
      427116  NM_001031415.1  NP_001026586.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARSK6
    arylsulfatase family, member K
    67(a)
    1 ↔ 1
    2(25875005-25896480)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arsk1 arylsulfatase family, member K 68.61(n)
    67.4(a)
      100485065  XM_002933439.2  XP_002933485.2 
    zebrafish
    (Danio rerio)
    Actinopterygii arsk1 arylsulfatase family, member K 63.15(n)
    62.47(a)
      562412  NM_001077157.1  NP_001070625.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120146
    --
    20(a)
    1 → many
    3L(3378268-3380083)
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0E00309g1 KLLA0E00309g 39.68(n)
    23.53(a)
      2894062  XM_453961.1  XP_453961.1 


    ENSEMBL Gene Tree for ARSK (if available)
    TreeFam Gene Tree for ARSK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARSK gene
    ENSG000002414892  IDS2  
    1 SIMAP similar gene for ARSK using alignment to 6 protein entries:     ARSK_HUMAN (see all proteins):
    SULF1

    ARSK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARSK (see all 882)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100442051,2
    C,F,H--94892862(+) cccatC/Tcccat 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1881569561,2
    --94892944(+) GAGACC/TACAGT 1 -- int10--------
    rs772810771,2
    F--94893023(+) TAGAAT/AGAGAA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1453709601,2
    --94893350(+) TGATTA/GTACCA 1 -- int10--------
    rs1491955791,2
    --94893412(+) CTGCAA/GGCTAA 1 -- int10--------
    rs1425475031,2
    --94893458(+) GAAAAC/TAGCAA 1 -- int10--------
    rs1509575331,2
    --94893511(+) TCAACC/TCCCAA 1 -- int10--------
    rs1144285971,2
    C,F--94893555(+) AAACTA/GTACAT 1 -- int11Minor allele frequency- G:0.04NA 120
    rs1927160531,2
    --94893568(+) AAACTA/GTTAAA 1 -- int10--------
    rs1419183261,2
    --94893629(+) ATGAAC/GAAACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ARSK (94890778 - 94940806 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARSK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882388CNV Loss21882294
    nsv830408CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARSK
    DNA2.0 Custom Variant and Variant Library Synthesis for ARSK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610011    OMIM disorders: --


    ARSK for disorders           About GeneDecksing


    Export disorders for ARSK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARSK gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ARSK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PubMed id 16174644)1, 2, 3 Sardiello M.... Ballabio A. (Hum. Mol. Genet. 2005)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Molecular cloning and initial characterization of three novel human sulfatases. (PubMed id 16500042)1, 2 Obaya A.J. (Gene 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Arylsulfatase K, a novel lysosomal sulfatase. (PubMed id 23986440)1 Wiegmann E.M....Dierks T. (J. Biol. Chem. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 153642 HGNC: 25239 AceView: DKFZp313G1735 Ensembl:ENSG00000164291 euGenes: HUgn153642
    ECgene: ARSK H-InvDB: ARSK

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARSK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARSK gene:
    Search GeneIP for patents involving ARSK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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