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Aliases for ARSK Gene

Aliases for ARSK Gene

  • Arylsulfatase Family Member K 2 3 5
  • Arylsulfatase Family, Member K 2 3
  • Telethon Sulfatase 3 4
  • TSULF 3 4
  • ASK 3 4
  • Arylsulfatase K 2
  • EC 3.1.6.- 4
  • EC 3.1.6 63

External Ids for ARSK Gene

Previous GeneCards Identifiers for ARSK Gene

  • GC05P094917
  • GC05P090081

Summaries for ARSK Gene

Entrez Gene Summary for ARSK Gene

  • Sulfatases (EC, such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARSK Gene

ARSK (Arylsulfatase Family Member K) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is IDS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSK Gene

Genomics for ARSK Gene

Regulatory Elements for ARSK Gene

Enhancers for ARSK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARSK on UCSC Golden Path with GeneCards custom track

Promoters for ARSK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARSK on UCSC Golden Path with GeneCards custom track

Genomic Location for ARSK Gene

95,555,074 bp from pter
95,605,102 bp from pter
50,029 bases
Plus strand

Genomic View for ARSK Gene

Genes around ARSK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARSK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARSK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSK Gene

Proteins for ARSK Gene

  • Protein details for ARSK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylsulfatase K
    Protein Accession:
    Secondary Accessions:
    • A2BDE3
    • B4E1I4
    • Q3ZCW3
    • Q8N3Q8

    Protein attributes for ARSK Gene

    536 amino acids
    Molecular mass:
    61450 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=AAH36047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ARSK Gene

Proteomics data for ARSK Gene at MOPED

Post-translational modifications for ARSK Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn 108, Asn 166, Asn 193, Asn 262, Asn 375, Asn 413, and Asn 498
  • Modification sites at PhosphoSitePlus

Other Protein References for ARSK Gene

Domains & Families for ARSK Gene

Gene Families for ARSK Gene

Protein Domains for ARSK Gene

Suggested Antigen Peptide Sequences for ARSK Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSK: view

Function for ARSK Gene

Enzyme Numbers (IUBMB) for ARSK Gene

genes like me logo Genes that share phenotypes with ARSK: view

Animal Models for ARSK Gene

MGI Knock Outs for ARSK:
  • Arsk tm1b(KOMP)Wtsi

Animal Model Products

miRNA for ARSK Gene

miRTarBase miRNAs that target ARSK

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARSK Gene

Localization for ARSK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSK Gene


Subcellular locations from

Jensen Localization Image for ARSK Gene COMPARTMENTS Subcellular localization image for ARSK gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
golgi apparatus 1
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ARSK Gene

Pathways & Interactions for ARSK Gene

genes like me logo Genes that share pathways with ARSK: view

Interacting Proteins for ARSK Gene

Gene Ontology (GO) - Biological Process for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ARSK: view

No data available for SIGNOR curated interactions for ARSK Gene

Drugs & Compounds for ARSK Gene

(1) Drugs for ARSK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ARSK: view

Transcripts for ARSK Gene

Unigene Clusters for ARSK Gene

Arylsulfatase family, member K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARSK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for ARSK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARSK Gene

mRNA expression in normal human tissues for ARSK Gene

Protein differential expression in normal tissues from HIPED for ARSK Gene

This gene is overexpressed in CD8 Tcells (30.1) and Ovary (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARSK Gene

SOURCE GeneReport for Unigene cluster for ARSK Gene Hs.585051

genes like me logo Genes that share expression patterns with ARSK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ARSK Gene

Orthologs for ARSK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARSK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARSK 35
  • 88.81 (n)
  • 88.79 (a)
  • 88 (a)
(Canis familiaris)
Mammalia ARSK 35
  • 89.37 (n)
  • 89.75 (a)
  • 89 (a)
(Mus musculus)
Mammalia Arsk 35
  • 83.8 (n)
  • 82.55 (a)
Arsk 16
Arsk 36
  • 79 (a)
(Pan troglodytes)
Mammalia ARSK 35
  • 99.07 (n)
  • 98.69 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Arsk 35
  • 83.55 (n)
  • 82.49 (a)
(Monodelphis domestica)
Mammalia ARSK 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia ARSK 36
  • 77 (a)
(Gallus gallus)
Aves ARSK 35
  • 74.98 (n)
  • 76.45 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia ARSK 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arsk 35
  • 68.61 (n)
  • 67.4 (a)
(Danio rerio)
Actinopterygii arsk 35
  • 63.15 (n)
  • 62.47 (a)
arsk 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12014 36
  • 20 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00309g 35
  • 39.68 (n)
  • 23.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08364 35
  • 40.78 (n)
  • 29.78 (a)
Species with no ortholog for ARSK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARSK Gene

Gene Tree for ARSK (if available)
Gene Tree for ARSK (if available)

Paralogs for ARSK Gene

Paralogs for ARSK Gene

(1) SIMAP similar genes for ARSK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARSK: view

Variants for ARSK Gene

Sequence variations from dbSNP and Humsavar for ARSK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs17084927 - 95,603,489(+) TGATC(A/G)GTGGC reference, missense
rs972390 -- 95,568,403(+) GTCAG(C/T)TCTCT intron-variant
rs2881976 -- 95,582,328(+) TAAAT(C/G)AGTAA intron-variant
rs6859414 -- 95,568,632(+) TGTAT(C/G)AATAA intron-variant
rs6864167 -- 95,566,142(+) TCCTT(A/G)ATATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARSK Gene

Variant ID Type Subtype PubMed ID
nsv882388 CNV Loss 21882294
nsv830408 CNV Loss 17160897

Variation tolerance for ARSK Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARSK Gene

Disorders for ARSK Gene

Relevant External Links for ARSK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARSK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARSK Gene

Publications for ARSK Gene

  1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PMID: 16174644) Sardiello M. … Ballabio A. (Hum. Mol. Genet. 2005) 2 3 4 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Arylsulfatase K, a novel lysosomal sulfatase. (PMID: 23986440) Wiegmann E.M. … Dierks T. (J. Biol. Chem. 2013) 3
  5. Molecular cloning and initial characterization of three novel human sulfatases. (PMID: 16500042) Obaya A.J. (Gene 2006) 3

Products for ARSK Gene

Sources for ARSK Gene