Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARSK Gene

protein-coding   GIFtS: 50
GCID: GC05P094917

arylsulfatase family, member K

(Previous name: arylsulfatase K )
  Search for ARSK
in our new
 Human Malady Compendium 
Biological research products
for ARSK
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Arylsulfatase Family, Member K1 2     ASK2 3
TSULF1 2 3     DKFZp313G17351
Arylsulfatase K1 2     EC 3.1.6.-3
Telethon Sulfatase2 3     EC 3.1.68

External Ids:    HGNC: 252391   Entrez Gene: 1536422   Ensembl: ENSG000001642917   OMIM: 6100115   UniProtKB: Q6UWY03   

Export aliases for ARSK gene to outside databases

Previous GC identifer: GC05P090081


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARSK:
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans,
and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of
macromolecules (Sardiello et al., 2005 (PubMed 16174644)).(supplied by OMIM, Mar 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARSK gene promoter:
         E2F-4   TBP   E2F-5   GATA-3   Lmo2   GATA-1   GATA-2   PPAR-alpha   HFH-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARSK promoter sequence
   Search SABiosciences Chromatin IP Primers for ARSK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARSK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q15

ARSK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARSK gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P094917:  view genomic region     (about GC identifiers)

Start:
94,890,778 bp from pter      End:
94,940,806 bp from pter
Size:
50,029 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARSK_HUMAN, Q6UWY0 (See protein sequence)
Recommended Name: Arylsulfatase K precursor  
Size: 536 amino acids; 61450 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=AAH36047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2BDE3 B4E1I4 Q3ZCW3 Q8N3Q8

Explore the universe of human proteins at neXtProt for ARSK: NX_Q6UWY0

Post-translational modifications:

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes
  • and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6UWY0

  • 4/17 DME Specific Peptides for ARSK (Q6UWY0) (see all 17)
     DPDELTN  YNKEQFI  YYAMCAE  NASTYML 

    ARSK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_937793.1  
    ENSEMBL proteins: 
     ENSP00000369346   ENSP00000422608   ENSP00000422126   ENSP00000423636   ENSP00000424018  
    Reactome Protein details: Q6UWY0
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ARSK
    OriGene Custom Protein Services for ARSK 
    GenScript Custom Purified and Recombinant Proteins Services for ARSK
    Novus Biologicals ARSK Protein
    Novus Biologicals ARSK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARSK

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005788endoplasmic reticulum lumen TAS--


    ARSK for ontologies           About GeneDecksing



    ARSK Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARSK 
    GenScript Custom Superior Antibodies Services for ARSK
    Novus Biologicals ARSK Antibodies
    Search for Antibodies for ARSK at Abcam  
    Uscn Antibodies for ARSK
    Search ThermoFisher Antibodies for ARSK

    Assay Products for ARSK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARSK
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ARSK


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ARSK for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q6UWY0

    ProtoNet protein and cluster: Q6UWY0

    1 Blocks protein family: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: ARSK_HUMAN, Q6UWY0
    Similarity: Belongs to the sulfatase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.62

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: ARSK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARSK
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ARSK:
    hsa-miR-2116*
    SwitchGear 3'UTR luciferase reporter plasmidARSK 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARSK (see all 7)
    OriGene shRNA RFP: ARSK
    OriGene siRNA: ARSK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARSK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARSK

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARSK (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARSK
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARSK (NM_198150)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSK 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARSK
    Search LifeMap BioReagents cell lines for ARSK

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSK

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004065arylsulfatase activity TAS16174644
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--


    ARSK for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ARSK:
     Increased S DNA content 

    Animal Models:
         1 MGI phenotypic allele for Arsk (no phenotypes)

    ARSK for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sphingolipid metabolism
    Sphingolipid metabolism1.00
    Glycosphingolipid metabolism0.54
    2PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation1.00
    The activation of arylsulfatases0.46
    3Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34
    4Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for ARSK (see all 8)
        Sphingolipid metabolism
    Glycosphingolipid metabolism
    Metabolism
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    Metabolism of proteins



    ARSK for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARSK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ARSK (ENSP000003693464) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSAENSP000002161244STRING: ENSP00000216124
    ARSBENSP000002649144STRING: ENSP00000264914
    ARSDENSP000003705464STRING: ENSP00000370546
    ARSEENSP000003705264STRING: ENSP00000370526
    ARSFENSP000003523194STRING: ENSP00000352319
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    ARSK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARSK

    1 HMDB Compound for ARSK    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about ARSK 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARSK gene: 
    NM_198150.2  

    Unigene Cluster for ARSK:

    Arylsulfatase family, member K
    Hs.585051  [show with all ESTs]
    Unigene Representative Sequence: NM_198150
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380009(uc003kld.3 uc010jbg.3 uc011cum.2) ENST00000513814
    ENST00000504763(uc003klc.3) ENST00000504873 ENST00000512106

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: ARSK
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARSK
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ARSK:
    hsa-miR-2116*
    SwitchGear 3'UTR luciferase reporter plasmidARSK 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARSK (see all 7)
    OriGene shRNA RFP: ARSK
    OriGene siRNA: ARSK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARSK
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARSK (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARSK
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARSK (NM_198150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSK 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARSK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARSK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARSK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSK

    Additional cDNA sequence: 

    AK303855.1 AK316253.1 AL832711.1 AY358596.1 AY875939.1 BC015723.2 BC036047.1 BC050392.1 
    BC080567.1 BC130329.1 BC144160.1 BC144161.1 

    4 DOTS entries:

    DT.40238437  DT.428830  DT.97832036  DT.97832037 

    24/57 AceView cDNA sequences (see all 57):

    BU630043 BX109484 NM_198150 AI243677 AA883670 AA314107 BC080567 BE295686 
    AI421965 BU527024 AW069167 BM923547 CA397780 CA442752 AA565548 AA548225 
    AY358596 BF478009 BC050392 AK126218 BF437866 AL832711 BG035392 BX107909 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARSK    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                          -                                                               
    SP2:                          -                 -                                             
    SP3:                          -           -     -                                             
    SP4:                                                                                          


    ECgene alternative splicing isoforms for ARSK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARSK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGCTTCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ARSK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARSK

    SOURCE GeneReport for Unigene cluster: Hs.585051
        SABiosciences Custom PCR Arrays for ARSK
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARSK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARSK
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARSK
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ARSK gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arsk1 , 5 arylsulfatase K1, 5 83.8(n)1
    82.55(a)1
      13 (40.95 cM)5
    770411  NM_029847.41  NP_084123.21 
     760604225 
    chicken
    (Gallus gallus)
    Aves ARSK1 arylsulfatase family, member K 73.78(n)
    74.42(a)
      427116  NM_001031415.1  NP_001026586.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARSK6
    --
    67(a)
    1 ↔ 1
    2(25875005-25896480)
    zebrafish
    (Danio rerio)
    Actinopterygii arsk1 arylsulfatase family, member K 63.15(n)
    62.47(a)
      562412  NM_001077157.1  NP_001070625.1 
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0E00309g1 hypothetical protein 40.73(n)
    25(a)
      2894062  XM_453961.1  XP_453961.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria yidJ6
    predicted sulfatase/phosphatase
    19(a)
    possible ortholog
    Chromosome(3854934-3856427)


    ENSEMBL Gene Tree for ARSK (if available)
    TreeFam Gene Tree for ARSK (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARSK gene
    SULF12  GNS2  SULF22  
    1 SIMAP similar gene for ARSK using alignment to 6 protein entries:     ARSK_HUMAN (see all proteins):
    SULF1

    ARSK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/740 NCBI SNPs in ARSK are shown (see all 740    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs100442051,2
    C,H,--94892862(+) cccatC/Tcccat 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs1881569561,2
    --94892944(+) GAGACC/TACAGT 1 -- int10--------
    rs772810771,2
    F,--94893023(+) TAGAAT/AGAGAA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1453709601,2
    --94893350(+) TGATTA/GTACCA 1 -- int10--------
    rs1491955791,2
    --94893412(+) CTGCAA/GGCTAA 1 -- int10--------
    rs1425475031,2
    --94893458(+) GAAAAC/TAGCAA 1 -- int10--------
    rs1509575331,2
    --94893511(+) TCAACC/TCCCAA 1 -- int10--------
    rs1144285971,2
    F,--94893555(+) AAACTA/GTACAT 1 -- int11Minor allele frequency- G:0.04NA 120
    rs1927160531,2
    --94893568(+) AAACTA/GTTAAA 1 -- int10--------
    rs1419183261,2
    --94893629(+) ATGAAC/GAAACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ARSK (94890778 - 94940806 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ARSK
         1 CNV: 4465

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARSK
    DNA2.0 Custom Variant and Variant Library Synthesis for ARSK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARSK for disorders           About MalaCards

    ARSK for disorders           About GeneDecksing

    OMIM gene information: 610011    OMIM disorders: --


    Export disorders for ARSK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARSK gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARSK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PubMed id 16174644)1, 2, 3 Sardiello M....Ballabio A. (2005)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    3. Molecular cloning and initial characterization of three novel human sulfatases. (PubMed id 16500042)1, 2 Obaya A.J. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 153642 HGNC: 25239 AceView: DKFZp313G1735 Ensembl:ENSG00000164291 euGenes: HUgn153642
    ECgene: ARSK H-InvDB: ARSK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARSK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARSK gene:
    Search GeneIP for patents involving ARSK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ARSK  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARSK   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARSK  
     OriGene Protein Over-expression Lysate for ARSK   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ARSK   OriGene 3'-UTR Clone for ARSK  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARSK   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARSK  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARSK   OriGene Custom Protein Services for ARSK  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARSK
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARSK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARSK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARSK
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSK
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARSK
     GenScript Custom Purified and Recombinant Proteins Services for ARSK GenScript cDNA clones with any tag delivered in your preferred vector for ARSK
     GenScript Custom Assay Services for ARSK GenScript Custom Superior Antibodies Services for ARSK
     GenScript Custom overexpressing Cell Line Services for ARSK CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARSK promoter
     Search Chromatin IP Primers for ARSK
     RT2 qPCR Primer Assay in human, mouse, rat ARSK
     Search GNC Networks for ARSK
     SABiosciences Custom PCR Arrays for ARSK
     Search Tocris compounds for ARSK
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARSK antibodies
     ARSK proteins
     ARSK lysates
     Search for Antibodies for ARSK at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ARSK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ARSK Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ARSK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSK
     SwitchGear 3'UTR luciferase reporter plasmids for ARSK
     SwitchGear Promoter luciferase reporter plasmids for ARSK
     Search ThermoFisher Antibodies for ARSK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSK
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARSK gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4