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Aliases for ARSK Gene

Aliases for ARSK Gene

  • Arylsulfatase Family Member K 2 3 5
  • Telethon Sulfatase 3 4
  • Arylsulfatase K 2 3
  • TSULF 3 4
  • ASK 3 4
  • Arylsulfatase Family, Member K 2
  • EC 3.1.6.- 4
  • EC 3.1.6 61

External Ids for ARSK Gene

Previous GeneCards Identifiers for ARSK Gene

  • GC05P094917
  • GC05P090081

Summaries for ARSK Gene

Entrez Gene Summary for ARSK Gene

  • Sulfatases (EC, such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARSK Gene

ARSK (Arylsulfatase Family Member K) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Metabolism. GO annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is IDS.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSK Gene

Genomics for ARSK Gene

Regulatory Elements for ARSK Gene

Enhancers for ARSK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G095705 0.9 dbSUPER 6.6 +151.6 151596 1.8 ATF1 ZNF133 FEZF1 ZNF766 ZNF202 SP3 ZNF592 CREB3 SMARCA4 GLIS1 SPATA9 ARSK GPR150 RHOBTB3
GH05G095706 0.8 dbSUPER 6.6 +151.3 151281 0.8 ZBTB21 ZNF133 INSM2 FEZF1 CHAMP1 ZEB1 ZNF335 GATA3 ZNF366 GLI2 ARSK SPATA9 RHOBTB3
GH05G095714 1.1 ENCODE dbSUPER 4.6 +160.1 160142 2.4 TBL1XR1 YBX1 BMI1 ZBTB40 ZNF335 FOS ZNF548 ETV6 IKZF2 CEBPB GLRX ARSK RHOBTB3 ENSG00000250240
GH05G095177 1.1 Ensembl ENCODE 4.1 -376.9 -376919 1.6 FEZF1 ZNF2 RAD21 GLIS2 ZSCAN5C KLF7 ZNF263 ZNF654 YY2 OVOL3 MCTP1 ENSG00000249545 ARSK LOC105379085
GH05G095392 0.8 ENCODE 5.1 -162.1 -162055 0.8 BCOR BACH1 ZMYM3 FOSL1 ZNF316 GATA2 ADNP NFE2 MAFK SMARCA5 ARSK LOC105379089 LOC100420911
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARSK on UCSC Golden Path with GeneCards custom track

Promoters for ARSK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ARSK Gene

95,555,074 bp from pter
95,605,102 bp from pter
50,029 bases
Plus strand

Genomic View for ARSK Gene

Genes around ARSK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARSK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARSK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSK Gene

Proteins for ARSK Gene

  • Protein details for ARSK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylsulfatase K
    Protein Accession:
    Secondary Accessions:
    • A2BDE3
    • B4E1I4
    • Q3ZCW3
    • Q8N3Q8

    Protein attributes for ARSK Gene

    536 amino acids
    Molecular mass:
    61450 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=AAH36047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ARSK Gene

Selected DME Specific Peptides for ARSK Gene


Post-translational modifications for ARSK Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at posLast=108108, posLast=166166, Asn193, posLast=262262, posLast=375375, posLast=413413, and Asn498
  • Modification sites at PhosphoSitePlus

Other Protein References for ARSK Gene

Domains & Families for ARSK Gene

Gene Families for ARSK Gene

Protein Domains for ARSK Gene

Suggested Antigen Peptide Sequences for ARSK Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSK: view

Function for ARSK Gene

Enzyme Numbers (IUBMB) for ARSK Gene

Gene Ontology (GO) - Molecular Function for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004065 arylsulfatase activity TAS 16174644
GO:0008484 sulfuric ester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARSK: view
genes like me logo Genes that share phenotypes with ARSK: view

Animal Models for ARSK Gene

MGI Knock Outs for ARSK:
  • Arsk tm1b(KOMP)Wtsi

Animal Model Products

miRNA for ARSK Gene

miRTarBase miRNAs that target ARSK

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARSK Gene

Localization for ARSK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSK Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARSK gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
lysosome 2
plasma membrane 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with ARSK: view

Pathways & Interactions for ARSK Gene

genes like me logo Genes that share pathways with ARSK: view

Gene Ontology (GO) - Biological Process for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ARSK: view

No data available for SIGNOR curated interactions for ARSK Gene

Drugs & Compounds for ARSK Gene

(1) Drugs for ARSK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ARSK: view

Transcripts for ARSK Gene

Unigene Clusters for ARSK Gene

Arylsulfatase family, member K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARSK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for ARSK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARSK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARSK Gene

Protein differential expression in normal tissues from HIPED for ARSK Gene

This gene is overexpressed in CD8 Tcells (30.1) and Ovary (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARSK Gene

NURSA nuclear receptor signaling pathways regulating expression of ARSK Gene:


SOURCE GeneReport for Unigene cluster for ARSK Gene:


Evidence on tissue expression from TISSUES for ARSK Gene

  • Nervous system(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with ARSK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARSK Gene

Orthologs for ARSK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARSK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARSK 34 35
  • 99.07 (n)
(Canis familiaris)
Mammalia ARSK 34 35
  • 89.37 (n)
(Bos Taurus)
Mammalia ARSK 34 35
  • 88.81 (n)
(Mus musculus)
Mammalia Arsk 34 16 35
  • 83.8 (n)
(Rattus norvegicus)
Mammalia Arsk 34
  • 83.55 (n)
(Ornithorhynchus anatinus)
Mammalia ARSK 35
  • 77 (a)
(Monodelphis domestica)
Mammalia ARSK 35
  • 67 (a)
(Gallus gallus)
Aves ARSK 34 35
  • 74.98 (n)
(Anolis carolinensis)
Reptilia ARSK 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arsk 34
  • 68.61 (n)
(Danio rerio)
Actinopterygii arsk 34 35
  • 63.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12014 35
  • 20 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00309g 34
  • 39.68 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08364 34
  • 40.78 (n)
Species where no ortholog for ARSK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARSK Gene

Gene Tree for ARSK (if available)
Gene Tree for ARSK (if available)

Paralogs for ARSK Gene

Paralogs for ARSK Gene

(1) SIMAP similar genes for ARSK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARSK: view

Variants for ARSK Gene

Sequence variations from dbSNP and Humsavar for ARSK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000093461 -- 95,555,405(+) CCTTC(G/T)TAAGT upstream-variant-2KB, splice-donor-variant
rs1000099574 -- 95,588,107(+) TCTGT(A/G)TCTAA intron-variant
rs1000119287 -- 95,585,107(+) AGGGA(A/G)ATGCA intron-variant
rs1000164381 -- 95,561,890(+) TGTGT(G/T)AATTA intron-variant
rs1000213811 -- 95,579,940(+) AAAAA(C/G)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARSK Gene

Variant ID Type Subtype PubMed ID
nsv598955 CNV gain 21841781
nsv830408 CNV loss 17160897

Variation tolerance for ARSK Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARSK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARSK Gene

Disorders for ARSK Gene

Relevant External Links for ARSK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARSK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARSK Gene

Publications for ARSK Gene

  1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PMID: 16174644) Sardiello M. … Ballabio A. (Hum. Mol. Genet. 2005) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  3. Molecular cloning and initial characterization of three novel human sulfatases. (PMID: 16500042) Obaya A.J. (Gene 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for ARSK Gene

Sources for ARSK Gene

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