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Aliases for ARSK Gene

Aliases for ARSK Gene

  • Arylsulfatase Family Member K 2 3 5
  • Telethon Sulfatase 3 4
  • Arylsulfatase K 2 3
  • TSULF 3 4
  • ASK 3 4
  • Arylsulfatase Family, Member K 2
  • EC 3.1.6.- 4
  • EC 3.1.6 58

External Ids for ARSK Gene

Previous GeneCards Identifiers for ARSK Gene

  • GC05P094917
  • GC05P090081

Summaries for ARSK Gene

Entrez Gene Summary for ARSK Gene

  • Sulfatases (EC, such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARSK Gene

ARSK (Arylsulfatase Family Member K) is a Protein Coding gene. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Metabolism. GO annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is IDS.

Additional gene information for ARSK Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSK Gene

Genomics for ARSK Gene

Regulatory Elements for ARSK Gene

Enhancers for ARSK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H095724 2 FANTOM5 Ensembl ENCODE dbSUPER 21.1 +175.2 175203 11.6 FEZF1 DMAP1 YY1 ZNF143 SP3 MEF2D GLIS1 NBN NR2C1 KDM1A ARSK TTC37 LOC105379096 ENSG00000249545 SPATA9 GLRX RHOBTB3 ELL2 ENSG00000250240
GH05H095705 0.9 dbSUPER 25.9 +151.6 151602 1.8 HDAC1 ATF1 NFRKB CHAMP1 ZNF766 ZNF202 SP3 ZBTB2 CEBPB ZEB2 ARSK TTC37 SPATA9 GPR150 RHOBTB3
GH05H095707 0.9 ENCODE 21.1 +152.6 152598 0.2 HDAC1 ATF1 NFRKB TCF12 ZNF766 CAVIN1 ZBTB2 ZBTB11 CEBPB ZEB2 ARSK TTC37 RHOBTB3 SPATA9
GH05H096197 1.4 Ensembl ENCODE dbSUPER 9.9 +644.1 644069 3.9 FOXA2 ATF1 DMAP1 RAD21 RARA ZNF121 SCRT2 CREM MIXL1 SP5 RIOK2 ARSK PCSK1 GC05M096211 RNU6-524P MIR583
GH05H096431 0.9 Ensembl 9.9 +876.6 876635 0.6 KLF17 ZEB1 GLIS2 EGR1 ZNF366 KLF7 EGR2 ZNF362 OVOL3 TSHZ1 RIOK2 ARSK GC05P096433 ENSG00000250158
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARSK on UCSC Golden Path with GeneCards custom track

Promoters for ARSK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ARSK Gene

Genomic Locations for ARSK Gene
50,029 bases
Plus strand

Genomic View for ARSK Gene

Genes around ARSK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARSK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARSK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSK Gene

Proteins for ARSK Gene

  • Protein details for ARSK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylsulfatase K
    Protein Accession:
    Secondary Accessions:
    • A2BDE3
    • B4E1I4
    • Q3ZCW3
    • Q8N3Q8

    Protein attributes for ARSK Gene

    536 amino acids
    Molecular mass:
    61450 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=AAH36047.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ARSK Gene

Selected DME Specific Peptides for ARSK Gene


Post-translational modifications for ARSK Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at posLast=108108, posLast=166166, Asn193, posLast=262262, posLast=375375, posLast=413413, and posLast=498498
  • Modification sites at PhosphoSitePlus

Other Protein References for ARSK Gene

Domains & Families for ARSK Gene

Gene Families for ARSK Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for ARSK Gene

Suggested Antigen Peptide Sequences for ARSK Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSK: view

Function for ARSK Gene

Enzyme Numbers (IUBMB) for ARSK Gene

Gene Ontology (GO) - Molecular Function for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004065 arylsulfatase activity TAS 16174644
GO:0008484 sulfuric ester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARSK: view
genes like me logo Genes that share phenotypes with ARSK: view

Animal Models for ARSK Gene

MGI Knock Outs for ARSK:
  • Arsk tm1b(KOMP)Wtsi

Animal Model Products

miRNA for ARSK Gene

miRTarBase miRNAs that target ARSK

Inhibitory RNA Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARSK Gene

Localization for ARSK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSK Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARSK gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
lysosome 2
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with ARSK: view

Pathways & Interactions for ARSK Gene

genes like me logo Genes that share pathways with ARSK: view

Gene Ontology (GO) - Biological Process for ARSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ARSK: view

No data available for SIGNOR curated interactions for ARSK Gene

Drugs & Compounds for ARSK Gene

(1) Drugs for ARSK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ARSK: view

Transcripts for ARSK Gene

Unigene Clusters for ARSK Gene

Arylsulfatase family, member K:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARSK Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for ARSK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARSK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARSK Gene

Protein differential expression in normal tissues from HIPED for ARSK Gene

This gene is overexpressed in CD8 Tcells (30.1) and Ovary (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARSK Gene

NURSA nuclear receptor signaling pathways regulating expression of ARSK Gene:


SOURCE GeneReport for Unigene cluster for ARSK Gene:


Evidence on tissue expression from TISSUES for ARSK Gene

  • Nervous system(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with ARSK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARSK Gene

Orthologs for ARSK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARSK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARSK 33 34
  • 99.07 (n)
(Canis familiaris)
Mammalia ARSK 33 34
  • 89.37 (n)
(Bos Taurus)
Mammalia ARSK 33 34
  • 88.81 (n)
(Mus musculus)
Mammalia Arsk 33 16 34
  • 83.8 (n)
(Rattus norvegicus)
Mammalia Arsk 33
  • 83.55 (n)
(Ornithorhynchus anatinus)
Mammalia ARSK 34
  • 77 (a)
(Monodelphis domestica)
Mammalia ARSK 34
  • 67 (a)
(Gallus gallus)
Aves ARSK 33 34
  • 74.98 (n)
(Anolis carolinensis)
Reptilia ARSK 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arsk 33
  • 68.61 (n)
(Danio rerio)
Actinopterygii arsk 33 34
  • 63.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12014 34
  • 20 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00309g 33
  • 39.68 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08364 33
  • 40.78 (n)
Species where no ortholog for ARSK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARSK Gene

Gene Tree for ARSK (if available)
Gene Tree for ARSK (if available)

Paralogs for ARSK Gene

Paralogs for ARSK Gene

(1) SIMAP similar genes for ARSK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARSK: view

Variants for ARSK Gene

Sequence variations from dbSNP and Humsavar for ARSK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000093461 -- 95,555,405(+) CCTTC(G/T)TAAGT upstream-variant-2KB, splice-donor-variant
rs1000099574 -- 95,588,107(+) TCTGT(A/G)TCTAA intron-variant
rs1000119287 -- 95,585,107(+) AGGGA(A/G)ATGCA intron-variant
rs1000164381 -- 95,561,890(+) TGTGT(G/T)AATTA intron-variant
rs1000213811 -- 95,579,940(+) AAAAA(C/G)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARSK Gene

Variant ID Type Subtype PubMed ID
nsv830408 CNV loss 17160897
nsv598955 CNV gain 21841781

Variation tolerance for ARSK Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARSK Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARSK Gene

Disorders for ARSK Gene

Relevant External Links for ARSK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARSK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARSK Gene

Publications for ARSK Gene

  1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PMID: 16174644) Sardiello M … Ballabio A (Human molecular genetics 2005) 2 3 4 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  3. Molecular cloning and initial characterization of three novel human sulfatases. (PMID: 16500042) Obaya AJ (Gene 2006) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for ARSK Gene

Sources for ARSK Gene

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