Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARSJ Gene

protein-coding   GIFtS: 56
GCID: GC04M114821

Arylsulfatase Family, Member J

(Previous name: arylsulfatase J)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Arylsulfatase Family, Member J1 2
Arylsulfatase J1 2
ASJ2 3
EC 3.1.6.-3
EC 3.1.68
EC 3.1.6.128

External Ids:    HGNC: 262861   Entrez Gene: 796422   Ensembl: ENSG000001808017   OMIM: 6100105   UniProtKB: Q5FYB03   

Export aliases for ARSJ gene to outside databases

Previous GC identifers: GC04M115180 GC04M115040 GC04M110549


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ARSJ Gene:
Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates,
proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and
degradation of macromolecules (Sardiello et al., 2005 (PubMed 16174644)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ARSJ Gene:
ARSJ (arylsulfatase family, member J) is a protein-coding gene. GO annotations related to this gene include arylsulfatase activity. An important paralog of this gene is ARSF.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARSJ gene promoter:
         TBP   LHX3b/Lhx3b   HOXA3   Tal-1   FOXL1   C/EBPalpha   E47   IRF-2   LHX3a/Lhx3a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARSJ promoter sequence
   Search Chromatin IP Primers for ARSJ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARSJ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

ARSJ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARSJ gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M114821:  view genomic region     (about GC identifiers)

Start:
114,821,440 bp from pter      End:
114,900,883 bp from pter
Size:
79,444 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARSJ_HUMAN, Q5FYB0 (See protein sequence)
Recommended Name: Arylsulfatase J precursor  
Size: 599 amino acids; 67235 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Sequence caution: Sequence=AAQ89010.1; Type=Frameshift; Positions=425;
Secondary accessions: A2RUG0 B7ZM45 Q1HA39 Q5FWE4 Q6UWT9

Explore the universe of human proteins at neXtProt for ARSJ: NX_Q5FYB0

Explore proteomics data for ARSJ at MOPED

Post-translational modifications: 

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
  • Glycosylation2 at Asn157, Asn306, Asn318, Asn431, Asn497, Asn527
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ARSJ (Q5FYB0) (see all 8)
     DVGYHGS  QPNCLPLD  KGTYWEGG  PTRRGFDT 


    See ARSJ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078866.3  
    ENSEMBL proteins: 
     ENSP00000320219   ENSP00000421327   ENSP00000438836  
    Reactome Protein details: Q5FYB0

    ARSJ Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ARSJ
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ARSJ
    GenScript Custom Purified and Recombinant Proteins Services for ARSJ
    Novus Biologicals ARSJ Protein
    Novus Biologicals ARSJ Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARSJ

     
    Search eBioscience for Proteins for ARSJ 

    ARSJ Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARSJ
    Novus Biologicals ARSJ Antibody
    Abcam antibodies for ARSJ (Q5FYB0, Q5FYB0 )
    Cloud-Clone Corp. Antibodies for ARSJ
    ThermoFisher Antibody for ARSJ
    LSBio Antibodies in human, mouse, rat for ARSJ

    ARSJ Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARSJ
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARSJ
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARSJ
    Cloud-Clone Corp. CLIAs for ARSJ
    Search eBioscience for ELISAs for ARSJ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ARS: Arylsulfatase family

    4 InterPro protein domains:
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR000917 Sulfatase
     IPR024607 Sulfatase_CS
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q5FYB0

    ProtoNet protein and cluster: Q5FYB0

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: ARSJ_HUMAN, Q5FYB0
    Similarity: Belongs to the sulfatase family


    Find genes that share domains with ARSJ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.6.122 EC 3.1.62

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004065arylsulfatase activity TAS16174644
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ARSJ           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARSJ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARSJ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARSJ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARSJ

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARSJ:
    hsa-mir-98-5p (MIRT027478), hsa-mir-93-5p (MIRT027943)

    Block miRNA regulation of human, mouse, rat ARSJ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARSJ (see all 35):
    hsa-miR-142-5p hsa-miR-520f hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-106a hsa-miR-513a-5p hsa-miR-570 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidARSJ 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARSJ
    Predesigned siRNA for gene silencing in human, mouse, rat ARSJ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARSJ

    Clone
    Products:
         
    OriGene clones in human, mouse for ARSJ (see all 7)
    OriGene ORF clones in mouse, rat for ARSJ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARSJ (NM_024590)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSJ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSJ

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARSJ
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARSJ 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSJ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ARSJ_HUMAN, Q5FYB0: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    extracellular3
    lysosome2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005788endoplasmic reticulum lumen TAS--

    Find genes that share ontologies with ARSJ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ARSJ About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Glycosphingolipid metabolism0.56
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    The activation of arylsulfatases0.00
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30


    Find genes that share SuperPaths with ARSJ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for ARSJ
        Glycosphingolipid metabolism
    The activation of arylsulfatases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARSJ
    Interactions:

        Search GeneGlobe Interaction Network for ARSJ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ARSJ (ENSP000003202194) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSAENSP000002161244STRING: ENSP00000216124
    ARSBENSP000002649144STRING: ENSP00000264914
    ARSDENSP000003705464STRING: ENSP00000370546
    ARSEENSP000003705264STRING: ENSP00000370526
    ARSFENSP000003523194STRING: ENSP00000352319
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with ARSJ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARSJ

    1 HMDB Compound for ARSJ    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARSJ gene: 
    NM_024590.3  

    Unigene Cluster for ARSJ:

    Arylsulfatase family, member J
    Hs.22895  [show with all ESTs]
    Unigene Representative Sequence: NM_024590
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315366(uc003ibq.1 uc010imu.1) ENST00000509829(uc010imv.1)
    ENST00000503013 ENST00000541197
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARSJ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARSJ (see all 35):
    hsa-miR-142-5p hsa-miR-520f hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-106a hsa-miR-513a-5p hsa-miR-570 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidARSJ 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARSJ
    Predesigned siRNA for gene silencing in human, mouse, rat ARSJ
    Clone
    Products:
         
    OriGene clones in human, mouse for ARSJ (see all 7)
    OriGene ORF clones in mouse, rat for ARSJ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARSJ (NM_024590)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSJ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSJ
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARSJ
    OriGene qSTAR qPCR primer pairs in human, mouse for ARSJ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARSJ
      QuantiTect SYBR Green Assays in human, mouse, rat ARSJ
      QuantiFast Probe-based Assays in human, mouse, rat ARSJ

    Additional mRNA sequence: 

    AK027201.1 AM049401.1 AY358647.1 AY875938.1 BC032010.1 BC033156.1 BC089445.1 BC132879.1 
    BC132881.1 BC142701.1 BC144265.1 BC151213.1 

    4 DOTS entries:

    DT.102829975  DT.40208583  DT.404969  DT.91651535 

    Selected AceView cDNA sequences (see all 26):

    AI087279 CA489050 BC033156 AI867679 AY358647 BQ922785 CB160803 BC032010 
    BG680752 NM_024590 AW470213 BG772761 CF995649 BX475192 BF307503 BQ957093 
    BX475395 BX952792 BF939415 BX486174 AA642619 BE544501 BF696654 BX952793 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ARSJ    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:        -                           
    SP2:              -     -     -         


    ECgene alternative splicing isoforms for ARSJ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARSJ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGAGGGAA
    ARSJ Expression
    About this image


    ARSJ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
    ARSJ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARSJ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22895
        Custom PCR Arrays for ARSJ
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARSJ
    OriGene qSTAR qPCR primer pairs in human, mouse for ARSJ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARSJ
    QuantiTect SYBR Green Assays in human, mouse, rat ARSJ
    QuantiFast Probe-based Assays in human, mouse, rat ARSJ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSJ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ARSJ gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arsj1 , 5 arylsulfatase J1, 5 86.32(n)1
    89.28(a)1
      3 (55.97 cM)5
    2719701  NM_173451.31  NP_775627.11 
     1263638275 
    chicken
    (Gallus gallus)
    Aves ARSJ1 arylsulfatase family, member J 78.68(n)
    86.95(a)
      422687  XM_420639.4  XP_420639.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    84(a)
    84(a)
    1 ↔ many
    1 ↔ many
    5(142267221-142309635)
    AAWZ02036864(19760-21377)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arsj1 arylsulfatase family, member J 72.67(n)
    80.52(a)
      100494972  XM_002934253.2  XP_002934299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5598001 arylsulfatase J-like 69.19(n)
    75.87(a)
      559800  XM_683173.3  XP_688265.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86466
    CG74026
    (see all 4)
    --
    36(a)
    32(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    2R(8543461-8546846)
    3L(17880805-17884504)
    worm
    (Caenorhabditis elegans)
    Secernentea sul-36
    Protein SUL-3, isoform b (sul-3) mRNA, complete cd...
    35(a)
    1 → many
    X(7827085-7834535) WBGene00006310


    ENSEMBL Gene Tree for ARSJ (if available)
    TreeFam Gene Tree for ARSJ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARSJ gene
    ARSF2  ARSI2  ARSG2  ARSA2  STS2  ARSH2  ARSB2  GALNS2  
    ARSE2  ARSD2  
    4 SIMAP similar genes for ARSJ using alignment to 3 protein entries:     ARSJ_HUMAN (see all proteins):
    ARSI    ARSB    ARSE    IDS

    Find genes that share paralogs with ARSJ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARSJ (see all 1718)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359865251,2
    C--114623999(+) GAGGG-/TGATGGG 1 -- int12Minor allele frequency- TG:0.25NA 4
    rs1485943491,2
    --114820950(+) CATTTC/TCAGTA 1 -- int10--------
    rs1429627891,2
    C--114821065(+) AATTTA/GCCTCT 1 -- int10--------
    rs1825534681,2
    --114821162(+) CTAGTC/GCTGTG 1 -- int10--------
    rs68166111,2
    C,F,H--114821256(+) TAAGAT/CTTTAA 1 -- int115Minor allele frequency- C:0.09NS EA CSA WA 2216
    rs1511017661,2
    C--114821524(+) TTTACA/GCTATA 1 -- ut310--------
    rs1876856471,2
    --114821786(+) CAGATC/TACAGT 1 -- ut310--------
    rs68456641,2
    C,F,H--114821980(+) TCCTCA/GTGACG 1 -- ut3110Minor allele frequency- G:0.07NS EA NA WA 1212
    rs1398699881,2
    --114822011(+) GCAAGA/GTTACC 1 -- ut310--------
    rs795169491,2
    C,F--114822073(+) CCACTT/GTGTAT 1 -- ut311Minor allele frequency- G:0.03EA 120

    HapMap Linkage Disequilibrium report for ARSJ (114821440 - 114900883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARSJ:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2320119CNV Deletion18987734
    esv2728165CNV Deletion23290073
    esv2728164CNV Deletion23290073
    esv2728163CNV Deletion23290073
    nsv524515CNV Gain19592680
    nsv525087CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARSJ
    DNA2.0 Custom Variant and Variant Library Synthesis for ARSJ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610010    OMIM disorders: --


    Find genes that share disorders with ARSJ           About GenesLikeMe

    Genetic Association Database (GAD): ARSJ
    Human Genome Epidemiology (HuGE) Navigator: ARSJ (1 document)

    Export disorders for ARSJ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARSJ gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ARSJ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PubMed id 16174644)1, 2, 3 Sardiello M.... Ballabio A. (Hum. Mol. Genet. 2005)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    4. Molecular cloning and initial characterization of three novel human sulfatases. (PubMed id 16500042)1, 2 Obaya A.J. (Gene 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    7. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79642 HGNC: 26286 AceView: FLJ23548 Ensembl:ENSG00000180801 euGenes: HUgn79642
    ECgene: ARSJ H-InvDB: ARSJ

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARSJ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARSJ gene:
    Search GeneIP for patents involving ARSJ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ARSJ  
     OriGene qPCR primer pairs and template standards for ARSJ   OriGene Protein Over-expression Lysate for ARSJ  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARSJ  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARSJ   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARSJ   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARSJ   OriGene Custom Protein Services for ARSJ  

     
     
     Block miRNA regulation of human, mouse, rat ARSJ using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARSJ
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARSJ Predesigned siRNA for gene silencing in human, mouse, rat ARSJ
     QuantiFast Probe-based Assays in human, mouse, rat ARSJ QuantiTect SYBR Green Assays in human, mouse, rat ARSJ
     Custom PCR Arrays for ARSJ Search Chromatin IP Primers for ARSJ
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARSJ  Search GeneGlobe Interaction Network for ARSJ
     Regulatory tfbs in ARSJ promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARSJ GenScript cDNA clones with any tag delivered in your preferred vector for ARSJ
     GenScript Custom Assay Services for ARSJ GenScript Custom overexpressing Cell Line Services for ARSJ
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ARSJ
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARSJ antibodies
     ARSJ proteins
     ARSJ lysates
     Antibodies for ARSJ
     See all of Abcam's Antibodies, Kits and Proteins for ARSJ
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ARSJ
     Antibodies for ARSJ
     ELISAs for ARSJ
     CLIAs for ARSJ



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARSJ
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSJ
     SwitchGear 3'UTR luciferase reporter plasmids for ARSJ
     SwitchGear Promoter luciferase reporter plasmids for ARSJ
     ThermoFisher Antibody for ARSJ
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSJ
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARSJ
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARSJ
     LSBio Antibodies in human, mouse, rat for ARSJ
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ARSJ
      Search eBioscience for proteins for ARSJ
      Search eBioscience for elisas for ARSJ
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARSJ gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4