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Aliases for ARSJ Gene

Aliases for ARSJ Gene

  • Arylsulfatase Family Member J 2 3 5
  • Arylsulfatase J 2 3
  • ASJ 3 4
  • Arylsulfatase Family, Member J 2
  • EC 61
  • EC 3.1.6.- 4
  • EC 3.1.6 61

External Ids for ARSJ Gene

Previous GeneCards Identifiers for ARSJ Gene

  • GC04M115180
  • GC04M115040
  • GC04M114821
  • GC04M110549

Summaries for ARSJ Gene

Entrez Gene Summary for ARSJ Gene

  • Sulfatases (EC, such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARSJ Gene

ARSJ (Arylsulfatase Family Member J) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is ARSI.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSJ Gene

Genomics for ARSJ Gene

Regulatory Elements for ARSJ Gene

Enhancers for ARSJ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F113957 0.8 Ensembl ENCODE 18.1 +20.8 20805 6.3 TBP INSM2 FEZF1 ZEB1 YY1 ZNF366 FOS CEBPB ZEB2 TSHZ1 ARSJ ENSG00000249304
GH04F113951 0.6 ENCODE 16.3 +29.8 29809 0.8 TCF7L2 ARSJ ENSG00000249304
GH04F114014 0.4 ENCODE 16.3 -34.1 -34051 2.2 JUN CEBPB SIN3A EP300 RAD21 OSR2 JUND STAT3 FOS PRDM1 ARSJ LOC105377376
GH04F114057 0.5 ENCODE 15.2 -76.3 -76327 0.9 CTCF ZNF652 ARSJ GC04P114056 ENSG00000248716
GH04F114004 0.4 Ensembl 12.2 -23.4 -23371 0.4 ARSJ LOC105377376
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARSJ on UCSC Golden Path with GeneCards custom track

Genomic Location for ARSJ Gene

113,900,284 bp from pter
113,981,430 bp from pter
81,147 bases
Minus strand

Genomic View for ARSJ Gene

Genes around ARSJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARSJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARSJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSJ Gene

Proteins for ARSJ Gene

  • Protein details for ARSJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylsulfatase J
    Protein Accession:
    Secondary Accessions:
    • A2RUG0
    • B7ZM45
    • Q1HA39
    • Q5FWE4
    • Q6UWT9

    Protein attributes for ARSJ Gene

    599 amino acids
    Molecular mass:
    67235 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89010.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305};

neXtProt entry for ARSJ Gene

Post-translational modifications for ARSJ Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn 157, Asn 306, Asn 318, Asn 431, Asn 497, and Asn 527
  • Modification sites at PhosphoSitePlus

Domains & Families for ARSJ Gene

Gene Families for ARSJ Gene

Protein Domains for ARSJ Gene

Suggested Antigen Peptide Sequences for ARSJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSJ: view

Function for ARSJ Gene

Enzyme Numbers (IUBMB) for ARSJ Gene

Gene Ontology (GO) - Molecular Function for ARSJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004065 arylsulfatase activity TAS 16174644
GO:0008484 sulfuric ester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARSJ: view
genes like me logo Genes that share phenotypes with ARSJ: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARSJ Gene

Localization for ARSJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSJ Gene


Subcellular locations from

Jensen Localization Image for ARSJ Gene COMPARTMENTS Subcellular localization image for ARSJ gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
lysosome 3
vacuole 3
cytoskeleton 1
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARSJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARSJ: view

Pathways & Interactions for ARSJ Gene

genes like me logo Genes that share pathways with ARSJ: view

Gene Ontology (GO) - Biological Process for ARSJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ARSJ: view

No data available for SIGNOR curated interactions for ARSJ Gene

Drugs & Compounds for ARSJ Gene

(1) Drugs for ARSJ Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ARSJ: view

Transcripts for ARSJ Gene

Unigene Clusters for ARSJ Gene

Arylsulfatase family, member J:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARSJ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: - - -

Relevant External Links for ARSJ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARSJ Gene

mRNA expression in normal human tissues for ARSJ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ARSJ Gene:


SOURCE GeneReport for Unigene cluster for ARSJ Gene:

genes like me logo Genes that share expression patterns with ARSJ: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ARSJ Gene

Orthologs for ARSJ Gene

This gene was present in the common ancestor of animals.

Orthologs for ARSJ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARSJ 34 35
  • 99.11 (n)
(Canis familiaris)
Mammalia ARSJ 34 35
  • 91.92 (n)
(Bos Taurus)
Mammalia ARSJ 34 35
  • 88.46 (n)
(Monodelphis domestica)
Mammalia ARSJ 35
  • 87 (a)
(Rattus norvegicus)
Mammalia Arsj 34
  • 86.71 (n)
(Mus musculus)
Mammalia Arsj 34 16 35
  • 86.32 (n)
(Gallus gallus)
Aves ARSJ 34 35
  • 78.68 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 84 (a)
-- 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arsj 34
  • 72.67 (n)
(Danio rerio)
Actinopterygii ARSJ 35
  • 70 (a)
LOC559800 34
  • 69.19 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7014 34
fruit fly
(Drosophila melanogaster)
Insecta CG8646 35
  • 36 (a)
CG7402 35
  • 32 (a)
CG32191 35
  • 31 (a)
CG7408 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea sul-3 35
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
-- 35
  • 45 (a)
-- 35
  • 38 (a)
CSA.11348 35
  • 34 (a)
Species where no ortholog for ARSJ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARSJ Gene

Gene Tree for ARSJ (if available)
Gene Tree for ARSJ (if available)

Paralogs for ARSJ Gene

Paralogs for ARSJ Gene

(4) SIMAP similar genes for ARSJ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARSJ: view

Variants for ARSJ Gene

Sequence variations from dbSNP and Humsavar for ARSJ Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10001850 -- 113,912,494(+) AGATA(C/T)ATAGA intron-variant
rs10006009 -- 113,924,064(+) atata(A/T)aaata intron-variant
rs10006019 -- 113,924,102(+) ATATA(A/T)ATATA intron-variant
rs10006021 -- 113,924,104(+) ATATA(A/T)ATATA intron-variant
rs10007297 -- 113,919,499(+) AACTG(A/T)TATTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARSJ Gene

Variant ID Type Subtype PubMed ID
esv2320119 CNV deletion 18987734
esv2728163 CNV deletion 23290073
esv2728164 CNV deletion 23290073
esv2728165 CNV deletion 23290073
esv3569667 CNV loss 25503493
nsv524515 CNV gain 19592680
nsv525087 CNV gain 19592680

Variation tolerance for ARSJ Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARSJ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARSJ Gene

Disorders for ARSJ Gene

Relevant External Links for ARSJ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARSJ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARSJ Gene

Publications for ARSJ Gene

  1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PMID: 16174644) Sardiello M. … Ballabio A. (Hum. Mol. Genet. 2005) 2 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
  4. Molecular cloning and initial characterization of three novel human sulfatases. (PMID: 16500042) Obaya A.J. (Gene 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ARSJ Gene

Sources for ARSJ Gene

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