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Aliases for ARSJ Gene

Aliases for ARSJ Gene

  • Arylsulfatase Family Member J 2 3 5
  • Arylsulfatase J 2 3
  • ASJ 3 4
  • Arylsulfatase Family, Member J 2
  • EC 3.1.6.12 58
  • EC 3.1.6.- 4
  • EC 3.1.6 58

External Ids for ARSJ Gene

Previous GeneCards Identifiers for ARSJ Gene

  • GC04M115180
  • GC04M115040
  • GC04M114821
  • GC04M110549

Summaries for ARSJ Gene

Entrez Gene Summary for ARSJ Gene

  • Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARSJ Gene

ARSJ (Arylsulfatase Family Member J) is a Protein Coding gene. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Metabolism. GO annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is ARSI.

Additional gene information for ARSJ Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSJ Gene

Genomics for ARSJ Gene

Regulatory Elements for ARSJ Gene

Enhancers for ARSJ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H113957 1.4 Ensembl ENCODE dbSUPER 18.1 +20.8 20805 6 TBP FOXA2 ZSCAN4 INSM2 FEZF1 BATF ZEB1 YY1 ZNF366 ZSCAN5C ARSJ ENSG00000249304
GH04H114014 0.9 Ensembl ENCODE 16.3 -34.1 -34051 2 JUN CHD1 CEBPB EP300 OSR2 JUND PRDM6 POLR2A ZSCAN5C STAT3 ARSJ LOC105377376
GH04H113951 0.6 ENCODE dbSUPER 16.3 +29.8 29809 0 JUND ARSJ ENSG00000249304
GH04H113975 1.1 ENCODE dbSUPER 7.7 +3.1 3095 5 CTCF ZNF146 FEZF1 EBF1 GLIS2 ZBTB48 ZNF366 POLR2A SCRT2 PRDM10 ARSJ ENSG00000249304
GH04H114057 0.5 ENCODE 15.2 -76.3 -76327 0 JUND HNF4A REST RAD21 ARSJ GC04P114056 ENSG00000248716
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARSJ on UCSC Golden Path with GeneCards custom track

Genomic Location for ARSJ Gene

Chromosome:
4
Start:
113,900,284 bp from pter
End:
113,981,430 bp from pter
Size:
81,147 bases
Orientation:
Minus strand

Genomic View for ARSJ Gene

Genes around ARSJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARSJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARSJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSJ Gene

Proteins for ARSJ Gene

  • Protein details for ARSJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5FYB0-ARSJ_HUMAN
    Recommended name:
    Arylsulfatase J
    Protein Accession:
    Q5FYB0
    Secondary Accessions:
    • A2RUG0
    • B7ZM45
    • Q1HA39
    • Q5FWE4
    • Q6UWT9

    Protein attributes for ARSJ Gene

    Size:
    599 amino acids
    Molecular mass:
    67235 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89010.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305};

neXtProt entry for ARSJ Gene

Selected DME Specific Peptides for ARSJ Gene

Q5FYB0:
  • QPNCLPLD
  • THMVGKWHLG
  • GFVHSPLLK
  • KGTYWEGG
  • GYSTHMVGKWHLGFYRK
  • PTRRGFDT
  • YQIHTGLQHSIIRP
  • DVGYHGS

Post-translational modifications for ARSJ Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn157, posLast=306306, posLast=318318, posLast=431431, Asn497, and Asn527
  • Modification sites at PhosphoSitePlus

Domains & Families for ARSJ Gene

Gene Families for ARSJ Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARSJ Gene

Suggested Antigen Peptide Sequences for ARSJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5FYB0

UniProtKB/Swiss-Prot:

ARSJ_HUMAN :
  • Belongs to the sulfatase family.
Family:
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSJ: view

Function for ARSJ Gene

Enzyme Numbers (IUBMB) for ARSJ Gene

Phenotypes From GWAS Catalog for ARSJ Gene

Gene Ontology (GO) - Molecular Function for ARSJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004065 arylsulfatase activity TAS 16174644
GO:0008484 sulfuric ester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARSJ: view
genes like me logo Genes that share phenotypes with ARSJ: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARSJ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARSJ Gene

Localization for ARSJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSJ Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARSJ gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
lysosome 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARSJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARSJ: view

Pathways & Interactions for ARSJ Gene

genes like me logo Genes that share pathways with ARSJ: view

Gene Ontology (GO) - Biological Process for ARSJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ARSJ: view

No data available for SIGNOR curated interactions for ARSJ Gene

Drugs & Compounds for ARSJ Gene

(1) Drugs for ARSJ Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ARSJ: view

Transcripts for ARSJ Gene

Unigene Clusters for ARSJ Gene

Arylsulfatase family, member J:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARSJ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARSJ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: - - -

Relevant External Links for ARSJ Gene

GeneLoc Exon Structure for
ARSJ
ECgene alternative splicing isoforms for
ARSJ

Expression for ARSJ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARSJ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ARSJ Gene:

ARSJ

SOURCE GeneReport for Unigene cluster for ARSJ Gene:

Hs.22895
genes like me logo Genes that share expression patterns with ARSJ: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARSJ Gene

Orthologs for ARSJ Gene

This gene was present in the common ancestor of animals.

Orthologs for ARSJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARSJ 33 34
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia ARSJ 33 34
  • 91.92 (n)
cow
(Bos Taurus)
Mammalia ARSJ 33 34
  • 88.46 (n)
oppossum
(Monodelphis domestica)
Mammalia ARSJ 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arsj 33
  • 86.71 (n)
mouse
(Mus musculus)
Mammalia Arsj 16 34 33
  • 86.32 (n)
chicken
(Gallus gallus)
Aves ARSJ 33 34
  • 78.68 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 84 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arsj 33
  • 72.67 (n)
zebrafish
(Danio rerio)
Actinopterygii ARSJ 34
  • 70 (a)
OneToOne
LOC559800 33
  • 69.19 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7014 33
fruit fly
(Drosophila melanogaster)
Insecta CG8646 34
  • 36 (a)
ManyToMany
CG7402 34
  • 32 (a)
ManyToMany
CG32191 34
  • 31 (a)
ManyToMany
CG7408 34
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea sul-3 34
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
CSA.11348 34
  • 34 (a)
ManyToMany
Species where no ortholog for ARSJ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARSJ Gene

ENSEMBL:
Gene Tree for ARSJ (if available)
TreeFam:
Gene Tree for ARSJ (if available)

Paralogs for ARSJ Gene

Paralogs for ARSJ Gene

(4) SIMAP similar genes for ARSJ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARSJ: view

Variants for ARSJ Gene

Sequence variations from dbSNP and Humsavar for ARSJ Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000002387 -- 113,922,737(+) TTTTG(C/T)TTGGT intron-variant
rs1000118461 -- 113,922,485(+) CCCCA(A/G)ATATA intron-variant
rs1000125629 -- 113,970,005(+) CTCAT(C/T)GTTGA intron-variant
rs10001850 -- 113,912,494(+) AGATA(C/T)ATAGA intron-variant
rs1000215898 -- 113,945,079(+) ATAGT(A/G)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARSJ Gene

Variant ID Type Subtype PubMed ID
esv2320119 CNV deletion 18987734
esv2728163 CNV deletion 23290073
esv2728164 CNV deletion 23290073
esv2728165 CNV deletion 23290073
esv3569667 CNV loss 25503493
nsv524515 CNV gain 19592680
nsv525087 CNV gain 19592680

Variation tolerance for ARSJ Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARSJ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARSJ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARSJ Gene

Disorders for ARSJ Gene

Relevant External Links for ARSJ

Genetic Association Database (GAD)
ARSJ
Human Genome Epidemiology (HuGE) Navigator
ARSJ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARSJ

No disorders were found for ARSJ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARSJ Gene

Publications for ARSJ Gene

  1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PMID: 16174644) Sardiello M … Ballabio A (Human molecular genetics 2005) 2 3 4 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  3. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 45 60
  4. Molecular cloning and initial characterization of three novel human sulfatases. (PMID: 16500042) Obaya AJ (Gene 2006) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for ARSJ Gene

Sources for ARSJ Gene

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