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Aliases for ARSJ Gene

Aliases for ARSJ Gene

  • Arylsulfatase Family, Member J 2 3
  • Arylsulfatase J 2 3
  • ASJ 3 4
  • EC 3.1.6.12 63
  • EC 3.1.6.- 4
  • EC 3.1.6 63

External Ids for ARSJ Gene

Previous GeneCards Identifiers for ARSJ Gene

  • GC04M115180
  • GC04M115040
  • GC04M114821
  • GC04M110549

Summaries for ARSJ Gene

Entrez Gene Summary for ARSJ Gene

  • Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARSJ Gene

ARSJ (Arylsulfatase Family, Member J) is a Protein Coding gene. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include arylsulfatase activity. An important paralog of this gene is ARSA.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSJ Gene

Genomics for ARSJ Gene

Regulatory Elements for ARSJ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARSJ Gene

Start:
113,900,284 bp from pter
End:
113,980,125 bp from pter
Size:
79,842 bases
Orientation:
Minus strand

Genomic View for ARSJ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARSJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSJ Gene

Proteins for ARSJ Gene

  • Protein details for ARSJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5FYB0-ARSJ_HUMAN
    Recommended name:
    Arylsulfatase J
    Protein Accession:
    Q5FYB0
    Secondary Accessions:
    • A2RUG0
    • B7ZM45
    • Q1HA39
    • Q5FWE4
    • Q6UWT9

    Protein attributes for ARSJ Gene

    Size:
    599 amino acids
    Molecular mass:
    67235 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89010.1; Type=Frameshift; Positions=425; Evidence={ECO:0000305};

neXtProt entry for ARSJ Gene

Proteomics data for ARSJ Gene at MOPED

Post-translational modifications for ARSJ Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn157, Asn306, Asn318, Asn431, Asn497, and Asn527
  • Modification sites at PhosphoSitePlus

Other Protein References for ARSJ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ARSJ Gene

Gene Families for ARSJ Gene

HGNC:
  • ARS :Arylsulfatase family

Protein Domains for ARSJ Gene

Suggested Antigen Peptide Sequences for ARSJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5FYB0

UniProtKB/Swiss-Prot:

ARSJ_HUMAN :
  • Q5FYB0
Family:
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSJ: view

Function for ARSJ Gene

Enzyme Numbers (IUBMB) for ARSJ Gene

Gene Ontology (GO) - Molecular Function for ARSJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004065 arylsulfatase activity TAS 16174644
GO:0008484 sulfuric ester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARSJ: view

miRNA for ARSJ Gene

miRTarBase miRNAs that target ARSJ

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARSJ

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARSJ Gene

Localization for ARSJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSJ Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARSJ Gene COMPARTMENTS Subcellular localization image for ARSJ gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
lysosome 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARSJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with ARSJ: view

Pathways for ARSJ Gene

genes like me logo Genes that share pathways with ARSJ: view

Interacting Proteins for ARSJ Gene

Gene Ontology (GO) - Biological Process for ARSJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0008152 metabolic process --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with ARSJ: view

Compounds for ARSJ Gene

(1) HMDB Compounds for ARSJ Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with ARSJ: view

Transcripts for ARSJ Gene

Unigene Clusters for ARSJ Gene

Arylsulfatase family, member J:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARSJ

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARSJ Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: - - -

Relevant External Links for ARSJ Gene

GeneLoc Exon Structure for
ARSJ
ECgene alternative splicing isoforms for
ARSJ

Expression for ARSJ Gene

mRNA expression in normal human tissues for ARSJ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ARSJ Gene Hs.22895

genes like me logo Genes that share expressions with ARSJ: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ARSJ Gene

Orthologs for ARSJ Gene

This gene was present in the common ancestor of animals.

Orthologs for ARSJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARSJ 35
  • 99.11 (n)
  • 99.16 (a)
ARSJ 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARSJ 35
  • 88.46 (n)
  • 92.81 (a)
ARSJ 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARSJ 35
  • 91.92 (n)
  • 96.62 (a)
ARSJ 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arsj 35
  • 86.32 (n)
  • 89.28 (a)
Arsj 16
Arsj 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARSJ 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arsj 35
  • 86.71 (n)
  • 90.28 (a)
chicken
(Gallus gallus)
Aves ARSJ 35
  • 78.68 (n)
  • 86.95 (a)
ARSJ 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arsj 35
  • 72.67 (n)
  • 80.52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7014 35
zebrafish
(Danio rerio)
Actinopterygii ARSJ 36
  • 70 (a)
OneToOne
LOC559800 35
  • 69.19 (n)
  • 75.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32191 36
  • 31 (a)
ManyToMany
CG7402 36
  • 32 (a)
ManyToMany
CG7408 36
  • 31 (a)
ManyToMany
CG8646 36
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea sul-3 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
CSA.11348 36
  • 34 (a)
ManyToMany
Species with no ortholog for ARSJ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARSJ Gene

ENSEMBL:
Gene Tree for ARSJ (if available)
TreeFam:
Gene Tree for ARSJ (if available)

Paralogs for ARSJ Gene

Paralogs for ARSJ Gene

Selected SIMAP similar genes for ARSJ Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARSJ: view

Variants for ARSJ Gene

Sequence variations from dbSNP and Humsavar for ARSJ Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs448392 -- 113,937,779(+) gaact(A/C)ccatt intron-variant
rs454420 -- 113,937,762(+) agagc(C/G)aaatc intron-variant
rs766182 -- 113,943,320(-) GTGTC(A/G)CAGGA intron-variant
rs766183 -- 113,943,176(-) AAACA(A/G)GAGCA intron-variant
rs766184 -- 113,943,085(-) ATGTA(C/G)TTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARSJ Gene

Variant ID Type Subtype PubMed ID
nsv525087 CNV Gain 19592680
esv2728163 CNV Deletion 23290073
esv2320119 CNV Deletion 18987734
esv2728164 CNV Deletion 23290073
esv2728165 CNV Deletion 23290073
nsv524515 CNV Gain 19592680

Relevant External Links for ARSJ Gene

HapMap Linkage Disequilibrium report
ARSJ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARSJ Gene

Disorders for ARSJ Gene

Relevant External Links for ARSJ

Genetic Association Database (GAD)
ARSJ
Human Genome Epidemiology (HuGE) Navigator
ARSJ
genes like me logo Genes that share disorders with ARSJ: view

No data available for UniProtKB/Swiss-Prot for ARSJ Gene

Publications for ARSJ Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PMID: 16174644) Sardiello M. … Ballabio A. (Hum. Mol. Genet. 2005) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Molecular cloning and initial characterization of three novel human sulfatases. (PMID: 16500042) Obaya A.J. (Gene 2006) 3 4
  5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 48

Products for ARSJ Gene

Sources for ARSJ Gene

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