ARSJ Gene
protein-coding GIFtS : 53
GCID: GC04 M114821
arylsulfatase family, member J (Previous name: arylsulfatase J )
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Aliasesfor ARSJ gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Arylsulfatase Family, Member J 1 2 EC 3.1.6.-3 Arylsulfatase J1 2 EC 3.1.68 ASJ2 3 EC 3.1.6.128 FLJ235481
Export aliases for ARSJ gene to outside databases Previous GC identifers: GC04M115180 GC04M115040 GC04M110549
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Summariesfor ARSJ gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ARSJ : Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 (PubMed 16174644)).(supplied by OMIM, Mar 2008)
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Genomic Viewsfor ARSJ gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARSJ gene promoter: TBP LHX3b/Lhx3b HOXA3 Tal-1 FOXL1 C/EBPalpha E47 IRF-2 LHX3a/Lhx3a En-1 Other transcription factors Search SABiosciences Chromatin IP Primers for ARSJ Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ARSJ
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q26 Ensembl cytogenetic band: 4q26 HGNC cytogenetic band: 4q26 ARSJ Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M114821: view genomic region
(about GC identifiers )
Start:
114,821,440 bp from pter
End:
114,900,883 bp from pter
Size:
79,444 bases
Orientation:
minus strand
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Proteinsfor ARSJ gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ARSJ_HUMAN, Q5FYB0 (See
protein sequence )Recommended Name: Arylsulfatase J precursor Size : 599 amino acids; 67235 Da
Cofactor : Binds 1 calcium ion per subunit (By similarity)
Subcellular location : Secreted (Potential)
Sequence caution : Sequence=AAQ89010.1; Type=Frameshift; Positions=425;
Secondary accessions : A2RUG0 B7ZM45 Q1HA39 Q5FWE4 Q6UWT9Explore the universe of human proteins at neXtProt for ARSJ: NX_Q5FYB0 Post-translational modifications:
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5FYB0 4/8 DME Specific Peptides for ARSJ (Q5FYB0 ) (see all 8 )ARSJ Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_078866.3 ENSEMBL proteins: ENSP00000320219 ENSP00000421327 ENSP00000438836 Reactome Protein details: Q5FYB0 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA -- GO:0005788 endoplasmic reticulum lumen
TAS --
ARSJ for ontologies About GeneDecksing ARSJ Antibody Products: Assay Products for ARSJ:
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Protein
Domains / Familiesfor ARSJ gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ARSJ for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q5FYB0 ProtoNet protein and cluster: Q5FYB0
1 Blocks protein family : IPB000917 Sulfatase UniProtKB/Swiss-Prot: ARSJ_HUMAN, Q5FYB0 Similarity : Belongs to the sulfatase family
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Functionfor ARSJ gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Enzyme Numbers (IUBMB): EC 3.1.6.- 1 EC 3.1.6.12 2 EC 3.1.6 2 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARSJ (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARSJ (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARSJ (NM_024590 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARSJ Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARSJ
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSJ
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
ARSJ for ontologies About GeneDecksing
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Pathways & Interactionsfor ARSJ gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Sphingolipid metabolism 2 PTM: gamma carboxylation, hypusine formation and arylsulfatase activation 3 Metabolism 4 Asparagine N-linked glycosylation
Pathway sources See GeneCards unified pathways Show all pathways 5/8
Reactome Pathways for ARSJ (see all 8 )
ARSJ for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARSJ STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)5/11 Interacting proteins for ARSJ (ENSP00000320219 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 11 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006644 phospholipid metabolic process
TAS -- GO:0006665 sphingolipid metabolic process
TAS -- GO:0006687 glycosphingolipid metabolic process
TAS -- GO:0043687 post-translational protein modification
TAS -- GO:0044267 cellular protein metabolic process
TAS --
ARSJ for ontologies About GeneDecksing
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Drugs & Compoundsfor ARSJ gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ARSJ 1 HMDB Compound for ARSJ About this table Search CenterWatch for drugs/clinical trials and news about ARSJ
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Transcriptsfor ARSJ gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ARSJ gene: NM_024590.3 Unigene Cluster for ARSJ:
Arylsulfatase family, member J Hs.22895 [show with all ESTs ] Unigene Representative Sequence: NM_024590 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000315366 (uc003ibq.1 uc010imu.1 ) ENST00000509829 (uc010imv.1 )ENST00000503013 ENST00000541197 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARSJ (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARSJ (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ARSJ (NM_024590 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARSJ Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARSJ
Additional cDNA sequence: AK027201.1 AM049401.1 AY358647.1 AY875938.1 BC032010.1 BC033156.1 BC089445.1 BC132879.1 BC132881.1 BC142701.1 BC144265.1 BC151213.1
4 DOTS entries : DT.102829975 DT.40208583
DT.404969 DT.91651535 24/26 AceView cDNA sequences (see all 26 ):
AI087279 AI867679 BC033156 CA489050 BQ922785 AW470213 BG680752 CB160803 AY358647 CF995649 BX475192 BC032010 BG772761 BF307503 NM_024590 BQ957093 BX475395 AA642619 BF939415 BX952792 BX486174 BG178749 BE544501 BX952793 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for ARSJ About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 SP1 :   -           SP2 :     -   -   -    
ECgene alternative splicing isoforms for ARSJ
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Expression for ARSJ gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ARSJ expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CGTGAGGGAA
About this image ARSJ expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ARSJ Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARSJ SOURCE GeneReport for Unigene cluster: Hs.22895 SABiosciences Custom PCR Arrays for ARSJ Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARSJBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ARSJ QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARSJ QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARSJ In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSJ
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Orthologsfor ARSJ gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ARSJ gene from 5/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for ARSJ (if available)TreeFam Gene Tree for ARSJ (if available)
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Paralogsfor ARSJ gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ARSJ gene ARSF 2 ARSI 2 ARSG 2 ARSA 2 ARSH 2 STS 2 ARSB 2 GALNS 2 ARSE 2 ARSD 2 4 SIMAP similar genes for ARSJ using alignment to 3 protein entries: ARSJ_HUMAN (see all proteins ):ARSI ARSB ARSE IDS
ARSJ for paralogs About GeneDecksing
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Genomic Variantsfor ARSJ gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARSJ
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Disorders
/ Diseasesfor ARSJ gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ARSJ for disorders About GeneDecksing
OMIM gene information: 610010
OMIM disorders : --5 diseases for ARSJ : About MalaCards alcohol dependence mucopolysaccharidosis alcoholism tuberculosis mycobacterium tuberculosis Human Genome Epidemiology (HuGE) Navigator: ARSJ (1 document)Export disorders for ARSJ gene to outside databases
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Publicationsfor ARSJ gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ARSJ gene integrated from 9 sources : (articles sorted by number of sources associating them with ARSJ) Utopia : connect your pdf to the dynamic world of online information
Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PubMed id 16174644) 1 , 2 , 3 Sardiello M....Ballabio A. (2005) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 , 3 Clark H.F.... Gray A.M. (2003) Molecular cloning and initial characterization of three novel human sulfatases. (PubMed id 16500042) 1 , 2 Obaya A.J. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099) 1 Kalsi G....Riley B.P. (2010) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Expression patterns of sulfatase genes in the develop ing mouse embryo. (PubMed id 20503373) 9 Ratzka A....Vortkamp A. (2010)
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External Searches for ARSJ gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ARSJ gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ARSJ gene
(According to HUGE )
About This Section --
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Specialized Databases showing ARSJ gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ARSJ Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ARSJ gene: Search GeneIP for patents involving ARSJ GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ARSJ gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ARSJ OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ARSJ OriGene Protein Over-expression Lysate for ARSJ Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ARSJ Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ARSJ OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ARSJ Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ARSJ OriGene Custom Protein Services for ARSJ OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARSJ QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ARSJ QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ARSJ QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ARSJ QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ARSJ QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ARSJ
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ARSJ Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSJ
ThermoFisher Antibody for ARSJ
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ARSJ
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