Aliases for ARSI Gene
External Ids for ARSI Gene
Previous GeneCards Identifiers for ARSI Gene
Sulfatases (EC 22.214.171.124), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ARSI Gene
ARSI (Arylsulfatase Family Member I) is a Protein Coding gene. Diseases associated with ARSI include Autosomal Recessive Spastic Paraplegia Type 66 and Spastic Paraplegia 66. Among its related pathways are Sphingolipid metabolism and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is ARSJ.
UniProtKB/Swiss-Prot for ARSI Gene
Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts.