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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARSI Gene

protein-coding   GIFtS: 53
GCID: GC05M149657

arylsulfatase family, member I

(Previous name: arylsulfatase I )
 Explore 7 diseases affiliated with
ARSI via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARSI    

Aliases
for ARSI gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Arylsulfatase Family, Member I1 2     EC 3.1.6.-3
Arylsulfatase I1 2     EC 3.1.68
ASI2 3     EC 3.1.6.128
FLJ160691     

External Ids:    HGNC: 325211   Entrez Gene: 3400752   Ensembl: ENSG000001838767   OMIM: 6100095   UniProtKB: Q5FYB13   

Export aliases for ARSI gene to outside databases

Previous GC identifer: GC05M144823


Summaries
for ARSI gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARSI:
Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans,
and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of
macromolecules (Sardiello et al., 2005 (PubMed 16174644)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ARSI_HUMAN, Q5FYB1
Function: Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is
measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts




Genomic Views
for ARSI gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARSI gene promoter:
         HOXA9B   HOXA9   Pax-5   Nkx2-5   Tal-1beta   Meis-1b   ITF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARSI promoter sequence
   Search SABiosciences Chromatin IP Primers for ARSI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARSI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

ARSI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARSI gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M149657:  view genomic region     (about GC identifiers)

Start:
 149,675,906 bp from pter      End:
 149,718,870 bp from pter
Size:
 42,965 bases      Orientation:
 minus strand

Proteins
for ARSI gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARSI_HUMAN, Q5FYB1 (See protein sequence)
Recommended Name: Arylsulfatase I precursor  
Size: 569 amino acids; 64030 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Secreted. Endoplasmic reticulum. Note=Localized in the intracellular granular structures
Caution: According to PubMed:16500042, has no arylsulfatase activity
Secondary accessions: A1L3B0 B3KV22 B7XD03
Alternative splicing: 2 isoforms:  Q5FYB1-1   Q5FYB1-2   

Explore the universe of human proteins at neXtProt for ARSI: NX_Q5FYB1

Post-translational modifications:

  • The oxidation of Cys-93 residue to 3-oxoalanine (also known as C(alpha)-formylglycine) by SUMF1/Sulfatase-modifying
    • factor 1, seems critical for catalytic activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5FYB1

    • 4/11 DME Specific Peptides for ARSI (Q5FYB1) (see all 11)
     DVGYHGS  QPNCLPLD  KGTYWEGG  PTRRGFDT 

    ARSI Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001012301.1  
    ENSEMBL proteins: 
     ENSP00000333395   ENSP00000426879   ENSP00000420955  
    Reactome Protein details: Q5FYB1
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ARSI
    OriGene Custom Protein Services for ARSI 
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    Novus Biologicals ARSI Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARSI

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005788endoplasmic reticulum lumen TAS--


    ARSI for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for ARSI

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    Uscn ELISAs and CLIAs for ARSI

    Protein Domains /
    Families
    for ARSI gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARSI for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024607 Sulfatase_CS
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q5FYB1

    ProtoNet protein and cluster: Q5FYB1

    1 Blocks protein family: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: ARSI_HUMAN, Q5FYB1
    Similarity: Belongs to the sulfatase family


    Function
    for ARSI gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARSI_HUMAN, Q5FYB1
    Function: Displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1; arylsulfatase activity is
    measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts

    Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.6.122 EC 3.1.62

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARSI
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ARSI (see all 10):
    hsa-miR-4283 hsa-miR-4324 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-4268 hsa-miR-125b hsa-miR-3622b-3p hsa-miR-1286
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARSI (see all 7)
    OriGene shRNA RFP: ARSI
    OriGene siRNA: ARSI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARSI

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARSI

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARSI (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARSI
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSI 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ARSI
    Search LifeMap BioReagents cell lines for ARSI

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSI

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004065arylsulfatase activity TAS16174644
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--


    ARSI for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ARSI:
     Decreased Salmonella enterica   Decreased Salmonella enterica  

    Animal Models:
         Mouse knock-out Arsitm1Anjm for ARSI
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Arsi):
     hematopoietic system 

    ARSI for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARSI gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sphingolipid metabolism
    		Sphingolipid metabolism1.00
    		Glycosphingolipid metabolism0.54
    2PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    		PTM: gamma carboxylation, hypusine formation and arylsulfatase activation1.00
    		The activation of arylsulfatases0.46
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    4Asparagine N-linked glycosylation
    		Post-translational protein modification0.44
    		Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for ARSI (see all 8)
        Sphingolipid metabolism
    Glycosphingolipid metabolism
    Metabolism
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    Metabolism of proteins



    ARSI for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARSI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ARSI (ENSP000003333954) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSAENSP000002161244STRING: ENSP00000216124
    ARSBENSP000002649144STRING: ENSP00000264914
    ARSDENSP000003705464STRING: ENSP00000370546
    ARSEENSP000003705264STRING: ENSP00000370526
    ARSFENSP000003523194STRING: ENSP00000352319
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    ARSI for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARSI gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARSI

    1 HMDB Compound for ARSI    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about ARSI 

    Transcripts
    for ARSI gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARSI gene: 
    NM_001012301.2  

    Unigene Cluster for ARSI:

    Arylsulfatase family, member I
    Hs.591252  [show with all ESTs]
    Unigene Representative Sequence: NM_001012301
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328668(uc003lrv.2) ENST00000515301 ENST00000509146

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate ARSI (see all 10):
    hsa-miR-4283 hsa-miR-4324 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-4268 hsa-miR-125b hsa-miR-3622b-3p hsa-miR-1286
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARSI (see all 7)
    OriGene shRNA RFP: ARSI
    OriGene siRNA: ARSI
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARSI
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARSI (NM_001012301)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSI 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARSI
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSI

    Additional cDNA sequence: 

    AB448735.1 AK122641.1 AY875937.1 BC111002.1 BC129995.1 BC129996.1 

    1 DOTS entry:

    DT.309933 

    24/28 AceView cDNA sequences (see all 28):

    BM670894 BM705410 BM693832 CR621346 AI445977 BU741038 AA622043 BU845825 
    AA428117 CA428531 BU681900 BX358614 AA358883 AI420538 AK122641 BM674324 
    AI187269 CA417016 CD673311 AI376957 BM704986 BU734778 AA568238 AA234540 

    GeneLoc Exon Structure


    Expression
    for ARSI gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARSI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGCTCTGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARSI expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See ARSI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARSI

    SOURCE GeneReport for Unigene cluster: Hs.591252

    UniProtKB/Swiss-Prot: ARSI_HUMAN, Q5FYB1
    Tissue specificity: Expressed in placenta, in embryonic stem cells, fetal eyes and lens

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSI

    Orthologs
    for ARSI gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARSI gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Arsi1 , 5 arylsulfatase i1, 5 87.87(n)1
    95.96(a)1    		   18 (34.41 cM)5
    5452601  NM_001038499.11  NP_001033588.11 
     609117805 
    chicken
    (Gallus gallus)    		 Aves ARSI1 arylsulfatase family, member I 79.19(n)
    84.13(a)    		   427639  XM_425212.1  XP_425212.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARSI6
    		 --
    		 76(a)
    		 1 ↔ 1
    		 2(139028674-139036258)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5637831 arylsulfatase I-like 65.66(n)
    69.55(a)    		   563783  XM_687145.4  XP_692237.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG321911 CG32191 47.26(n)
    38.1(a)    		   317903  NM_168750.3  NP_730304.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea sul-36
    		 SULfatase domain protein family member (sul-3)
    		 26(a)
    		 possible ortholog
    		 X(7827034-7834484)


    ENSEMBL Gene Tree for ARSI (if available)
    TreeFam Gene Tree for ARSI (if available) 

    Paralogs
    for ARSI gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARSI gene
    ARSF2  ARSJ2  ARSG2  ARSA2  ARSH2  STS2  ARSB2  GALNS2  
    ARSE2  ARSD2  
    3 SIMAP similar genes for ARSI using alignment to 2 protein entries:     ARSI_HUMAN (see all proteins):
    ARSJ    ARSB    IDS

    ARSI for paralogs           About GeneDecksing



    Genomic Variants
    for ARSI gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/185 NCBI SNPs in ARSI are shown (see all 185)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs728059211,2
    		C,--149675783(+) CCACCG/TCCTAG 1 -- int16Minor allele frequency- T:0.13CSA WA NA EA 362
    rs1452545621,2
    		--149675880(+) GCTCAC/TAGTCA 1 -- int10--------
    rs1449870901,2
    		--149675962(+) CCAGTC/TTTCCA 1 -- ut310--------
    rs728059221,2
    		C,--149675998(+) GGGCTG/AGCATC 1 -- ut315Minor allele frequency- A:0.13CSA WA NA EA 361
    rs1394991111,2
    		--149676259(+) GTCAA-/CCCCCC 1 -- ut310--------
    rs623826741,2
    		--149676293(+) CGCTTG/AGGGGT 1 -- ut313Minor allele frequency- A:0.06NA EA 242
    rs171111181,2
    		C,F,H,--149676297(+) TGGGGG/TTCCCT 1 -- ut3118Minor allele frequency- T:0.10NA NS EA CSA WA 2171
    rs1163674371,2
    		F,--149676363(+) CCAGGC/GAACTC 1 -- ut311Minor allele frequency- G:0.04WA 118
    rs1486460531,2
    		--149676463(+) CCAGGA/CTCCAG 1 -- ut310--------
    rs1421069961,2
    		--149676466(+) GGCTCC/TAGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARSI (149675906 - 149718870 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARSI: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARSI
    DNA2.0 Custom Variant and Variant Library Synthesis for ARSI

    Disorders / Diseases
    for ARSI gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARSI for disorders           About GeneDecksing

    OMIM gene information: 610009    OMIM disorders: --

    7 diseases for ARSI:    About MalaCards
    louse-borne relapsing fever    relapsing fever    xerophthalmia    mucopolysaccharidosis
    retinitis    tuberculosis    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for ARSI:
    Xerophthalmia     Relapsing fever

    Export disorders for ARSI gene to outside databases

    Publications
    for ARSI gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARSI gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARSI)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PubMed id 16174644)1, 2, 3 Sardiello M....Ballabio A. (2005)
    2. Characterization of the arylsulfatase I (ARSI) gene preferentially expressed in the human retinal pigment epithelium cell line ARPE-19. (PubMed id 19262745)1, 2, 9 Oshikawa M.... Kato S. (2009)
    3. Molecular cloning and initial characterization of three novel human sulfatases. (PubMed id 16500042)1, 2 Obaya A.J. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Expression patterns of sulfatase genes in the develop ing mouse embryo. (PubMed id 20503373)9 Ratzka A....Vortkamp A. (2010)

    External Searches for ARSI gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing ARSI gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340075 HGNC: 32521 AceView: LOC340075 Ensembl:ENSG00000183876 euGenes: HUgn340075
    ECgene: ARSI H-InvDB: ARSI

    Other Databases showing ARSI gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARSI gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARSI Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARSI gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARSI gene:
    Search GeneIP for patents involving ARSI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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