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Aliases for ARSH Gene

Aliases for ARSH Gene

  • Arylsulfatase Family, Member H 2 3
  • Arylsulfatase H 2 3
  • ASH 3 4
  • EC 63
  • EC 3.1.6.- 4
  • Sulfatase 3
  • EC 3.1.6 63

External Ids for ARSH Gene

Previous GeneCards Identifiers for ARSH Gene

  • GC0XP002919
  • GC0XP000867

Summaries for ARSH Gene

Entrez Gene Summary for ARSH Gene

  • Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARSH Gene

ARSH (Arylsulfatase Family, Member H) is a Protein Coding gene. Diseases associated with ARSH include breast cyst and multiple sulfatase deficiency. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include arylsulfatase activity. An important paralog of this gene is ARSJ.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSH Gene

Genomics for ARSH Gene

Regulatory Elements for ARSH Gene

Transcription factor binding sites by QIAGEN in the ARSH gene promoter:

Genomic Location for ARSH Gene

3,006,613 bp from pter
3,033,571 bp from pter
26,959 bases
Plus strand

Genomic View for ARSH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARSH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSH Gene

Proteins for ARSH Gene

  • Protein details for ARSH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylsulfatase H
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ARSH Gene

    562 amino acids
    Molecular mass:
    63525 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for ARSH Gene

Proteomics data for ARSH Gene at MOPED

Selected DME Specific Peptides for ARSH Gene

Post-translational modifications for ARSH Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARSH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ARSH Gene

Gene Families for ARSH Gene

  • ARS :Arylsulfatase family

Protein Domains for ARSH Gene

Suggested Antigen Peptide Sequences for ARSH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5FYA8
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSH: view

Function for ARSH Gene

Enzyme Numbers (IUBMB) for ARSH Gene

Gene Ontology (GO) - Molecular Function for ARSH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004065 arylsulfatase activity TAS 16174644
GO:0008484 sulfuric ester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARSH: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARSH

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARSH Gene

Localization for ARSH Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSH Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ARSH Gene COMPARTMENTS Subcellular localization image for ARSH gene
Compartment Confidence
endoplasmic reticulum 4
lysosome 3
plasma membrane 3
cytosol 2
extracellular 2
golgi apparatus 2
vacuole 2
endosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARSH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARSH: view

Pathways for ARSH Gene

genes like me logo Genes that share pathways with ARSH: view

Interacting Proteins for ARSH Gene

Gene Ontology (GO) - Biological Process for ARSH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0008152 metabolic process --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with ARSH: view

Compounds for ARSH Gene

(1) HMDB Compounds for ARSH Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(77) Novoseek inferred chemical compound relationships for ARSH Gene

Compound -log(P) Hits PubMed IDs
formylglycine 97 45
estrone sulfate 90.3 21
medrogestone 88.7 12
promegestone 88.1 10
p-nitrocatechol sulfate 88 1
genes like me logo Genes that share compounds with ARSH: view

Transcripts for ARSH Gene

mRNA/cDNA for ARSH Gene

(6) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARSH Gene

Arylsulfatase family, member H:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARSH

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARSH Gene

No ASD Table

Relevant External Links for ARSH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARSH Gene

mRNA expression in normal human tissues for ARSH Gene

mRNA differential expression in normal tissues according to GTEx for ARSH Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (12.3), Esophagus - Mucosa (9.1), and Minor Salivary Gland (5.5).

Protein differential expression in normal tissues for ARSH Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARSH Gene

SOURCE GeneReport for Unigene cluster for ARSH Gene Hs.351533

genes like me logo Genes that share expressions with ARSH: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARSH Gene

Orthologs for ARSH Gene

This gene was present in the common ancestor of animals.

Orthologs for ARSH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARSH 35
  • 77.54 (n)
  • 81.28 (a)
  • 81 (a)
(Canis familiaris)
Mammalia ARSH 35
  • 84.67 (n)
  • 88.95 (a)
  • 89 (a)
(Pan troglodytes)
Mammalia ARSH 35
  • 98.99 (n)
  • 98.22 (a)
  • 98 (a)
(Monodelphis domestica)
Mammalia ARSH 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia ARSH 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
(Danio rerio)
Actinopterygii arsh 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea sul-2 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for ARSH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARSH Gene

Gene Tree for ARSH (if available)
Gene Tree for ARSH (if available)

Paralogs for ARSH Gene

Paralogs for ARSH Gene

Selected SIMAP similar genes for ARSH Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARSH: view

Variants for ARSH Gene

Sequence variations from dbSNP and Humsavar for ARSH Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs768941 -- 3,025,843(-) CTCAT(A/G)Caatt intron-variant
rs768942 -- 3,025,770(-) CACTT(C/T)GTTAG intron-variant
rs1454502 -- 3,013,603(-) CCCCC(C/G)GCCCC intron-variant
rs1454503 -- 3,013,503(-) AGTTT(C/T)CCATT intron-variant
rs1470938 -- 3,012,320(-) CCTCA(A/C)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARSH Gene

Variant ID Type Subtype PubMed ID
dgv2432e1 CNV Complex 17122850
esv34985 CNV Gain 17911159
essv3621 CNV CNV 17122850
esv33241 CNV Loss 17666407
esv2674359 CNV Deletion 23128226
dgv13n29 CNV Gain 16826518

Relevant External Links for ARSH Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARSH Gene

Disorders for ARSH Gene

(33) Novoseek inferred disease relationships for ARSH Gene

Disease -log(P) Hits PubMed IDs
multiple sulfatase deficiency 98.2 86
leukodystrophy metachromatic 82.2 6
mucopolysaccharidosis 78.1 8
ichthyosis x-linked 77.8 2
morquios syndrome 71.2 2
genes like me logo Genes that share disorders with ARSH: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for ARSH Gene

Publications for ARSH Gene

  1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PMID: 16174644) Sardiello M. … Ballabio A. (Hum. Mol. Genet. 2005) 2 3 4 23
  2. Pharmacokinetics and pharmacodynamics in clinical use of scopolamine. (PMID: 16175141) Renner U.D. … Kirch W. (Ther Drug Monit 2005) 23
  3. Expression analysis of estrogen-metabolizing enzymes in human endometrial cancer. (PMID: 16337331) Smuc T. … Rizner T.L. (Mol. Cell. Endocrinol. 2006) 23
  4. A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme. (PMID: 16368756) Roeser D. … Rudolph M.G. (Proc. Natl. Acad. Sci. U.S.A. 2006) 23
  5. Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2. (PMID: 16377625) Ai X. … Emerson C.P. (J. Biol. Chem. 2006) 23

Products for ARSH Gene

Sources for ARSH Gene

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