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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARSH Gene

protein-coding   GIFtS: 48
GCID: GC0XP002919

Arylsulfatase Family, Member H

(Previous name: arylsulfatase H)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arylsulfatase Family, Member H1 2     EC 3.1.6.-3
Arylsulfatase H1 2     EC 3.1.68
ASH2 3     EC 3.1.6.28
sulfatase2     

External Ids:    HGNC: 324881   Entrez Gene: 3475272   Ensembl: ENSG000002056677   OMIM: 3005865   UniProtKB: Q5FYA83   

Export aliases for ARSH gene to outside databases

Previous GC identifer: GC0XP000867


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARSH Gene:
Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and
glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of
macromolecules (Sardiello et al., 2005 (PubMed 16174644)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ARSH Gene: 
ARSH (arylsulfatase family, member H) is a protein-coding gene. Diseases associated with ARSH include endometriosis of ovary, and mucopolysaccharidosis vi, and among its related super-pathways are Sphingolipid metabolism and The activation of arylsulfatases. GO annotations related to this gene include arylsulfatase activity and metal ion binding. An important paralog of this gene is ARSF.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARSH gene promoter:
         p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARSH promoter sequence
   Search SABiosciences Chromatin IP Primers for ARSH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARSH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.33

ARSH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARSH gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP002919:  view genomic region     (about GC identifiers)

Start:
2,924,654 bp from pter      End:
2,951,612 bp from pter
Size:
26,959 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARSH_HUMAN, Q5FYA8 (See protein sequence)
Recommended Name: Arylsulfatase H  
Size: 562 amino acids; 63525 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for ARSH: NX_Q5FYA8

Explore proteomics data for ARSH at MOPED 

Post-translational modifications:

  • UniProtKB: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)
  • View neXtProt modification sites for NX_Q5FYA8

  • 4/6 DME Specific Peptides for ARSH (Q5FYA8) (see all 6)
     NGIYKGG  HDPPLLFD  AFLTGRYP  HEFLFHYC 

    ARSH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARSH Protein Expression
    REFSEQ proteins: NP_001011719.1  
    ENSEMBL proteins: 
     ENSP00000370522  
    Reactome Protein details: Q5FYA8
    Human Recombinant Protein Products for ARSH: 
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    Novus Biologicals ARSH Protein
    Novus Biologicals ARSH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARSH 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0016021integral to membrane IEA--

    ARSH for ontologies           About GeneDecksing



    ARSH Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ARSH 

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    Cloud-Clone Corp. CLIAs for ARSH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARS: Arylsulfatase family

    4 InterPro protein domains:
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024607 Sulfatase_CS
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q5FYA8

    ProtoNet protein and cluster: Q5FYA8

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: ARSH_HUMAN, Q5FYA8
    Similarity: Belongs to the sulfatase family


    ARSH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.6.22 EC 3.1.62

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004065arylsulfatase activity TAS16174644
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    ARSH for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARSH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARSH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARSH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARSH 

    miRNA
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARSH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.63
    Glycosphingolipid metabolism0.55
    2PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation0.46
    The activation of arylsulfatases0.46
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for ARSH (see all 8)
        Sphingolipid metabolism
    Glycosphingolipid metabolism
    Metabolism
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    Metabolism of proteins



    ARSH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARSH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ARSH (ENSP000003705224) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSAENSP000002161244STRING: ENSP00000216124
    ARSBENSP000002649144STRING: ENSP00000264914
    ARSDENSP000003705464STRING: ENSP00000370546
    ARSEENSP000003705264STRING: ENSP00000370526
    ARSFENSP000003523194STRING: ENSP00000352319
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    ARSH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARSH for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARSH

    1 HMDB Compound for ARSH    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/77 Novoseek inferred chemical compound relationships for ARSH gene (see all 77)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    formylglycine 97 61 18305113 (4), 14563551 (3), 9497327 (3), 16399355 (2) (see all 28)
    estrone sulfate 90.3 25 2375600 (2), 8338787 (2), 2298851 (1), 12711003 (1) (see all 19)
    medrogestone 88.7 12 10529001 (2), 12227886 (1), 19179024 (1), 10419004 (1) (see all 11)
    promegestone 88.1 10 12227886 (1), 19179024 (1), 10862262 (1), 19962254 (1) (see all 10)
    p-nitrocatechol sulfate 88 1 8824834 (1)
    estrone 87.8 29 9009236 (3), 9096642 (2), 17064891 (2), 15302278 (1) (see all 22)
    17beta-hydroxysteroid 87.6 30 20204307 (4), 10862262 (2), 15274306 (2), 11384867 (2) (see all 22)
    nomegestrol acetate 86.9 15 16080533 (3), 15748827 (2), 12227886 (1), 19179024 (1) (see all 12)
    4-methylumbelliferyl sulfate 85.2 4 11177574 (2), 8920232 (1)
    1-menaphthyl sulfate 84.7 1 10548067 (1)

    Search CenterWatch for drugs/clinical trials and news about ARSH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARSH gene: 
    NM_001011719.1  

    Unigene Cluster for ARSH:

    Arylsulfatase family, member H
    Hs.351533  [show with all ESTs]
    Unigene Representative Sequence: AY875940
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381130(uc011mhj.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSH
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    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ARSH
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSH

    Additional mRNA sequence: AY875940.1 

    1 DOTS entry:

    DT.95307360 

    6 AceView cDNA sequences:

    CK904764 CK904763 BM069810 AX801696 BM069570 AI868403 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARSH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARSH Expression
    About this image


    See ARSH Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.351533
        SABiosciences Custom PCR Arrays for ARSH
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARSH gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ARSH1 arylsulfatase family, member H 84.67(n)
    88.95(a)
      491720  NM_001048123.1  NP_001041588.1 
    chicken
    (Gallus gallus)
    Aves ARSD1 arylsulfatase D 69.32(n)
    68.66(a)
      418658  XM_416855.2  XP_416855.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    60(a)
    59(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3(113992166-114011589)
    3(114037137-114062932)
    zebrafish
    (Danio rerio)
    Actinopterygii arsh6
    arylsulfatase H
    49(a)
    1 → many
    9(57794391-57813088)
    worm
    (Caenorhabditis elegans)
    Secernentea sul-26
    Protein SUL-2
    30(a)
    1 → many
    V(8157746-8159874)


    ENSEMBL Gene Tree for ARSH (if available)
    TreeFam Gene Tree for ARSH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARSH gene
    ARSF2  ARSI2  ARSJ2  ARSG2  ARSA2  STS2  ARSB2  GALNS2  
    ARSE2  ARSD2  
    5 SIMAP similar genes for ARSH using alignment to 1 protein entry:     ARSH_HUMAN:
    ARSD    ARSE    ARSF    STS    IDS

    ARSH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/595 SNPs in ARSH are shown (see all 595)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59394031,2
    C,A--2922687(+) GTTTCC/TTTTCT 1 -- us2k1 trp30--------
    rs1420190041,2
    C--2922907(+) CACAT-/ACAC  
            
    CACAC
    1 -- us2k10--------
    rs2019067811,2
    --2922924(+) ACACA-/CACC  
            
    CCTAT
    1 -- us2k10--------
    rs1402313981,2
    --2922925(+) CACACA/TCCCCT 1 -- us2k10--------
    rs1411683511,2
    --2923014(+) GGCGCA/GATCTT 1 -- us2k10--------
    rs1837865011,2
    --2923235(+) ACAGGC/TGCGTG 1 -- us2k10--------
    rs1124698151,2
    C,F--2923300(+) TGTCAA/GGCTGG 1 -- us2k12Minor allele frequency- G:0.33NA WA 3
    rs1877512001,2
    --2923375(+) ATGAGA/CCACTG 1 -- us2k10--------
    rs1911178801,2
    --2923377(+) GAGCCA/CCTGTG 1 -- us2k10--------
    rs1113814441,2
    C,F--2923439(+) TGAGAC/G/TAGGGT 1 -- us2k11NA 1

    HapMap Linkage Disequilibrium report for ARSH (2924654 - 2951612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARSH:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674359CNV Deletion23128226
    esv33241CNV Loss17666407
    esv34985CNV Gain17911159
    dgv13n29CNV Gain16826518
    essv3621CNV CNV17122850
    dgv2432e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): ARSH
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARSH
    DNA2.0 Custom Variant and Variant Library Synthesis for ARSH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300586    OMIM disorders: --

    20/46 diseases for ARSH (see all 46):    About MalaCards
    endometriosis of ovary    mucopolysaccharidosis vi    mucolipidosis ii    ovarian endometriosis
    beta-ketothiolase deficiency    breast fibroadenoma    ketothiolase deficiency    mucopolysaccharidosis
    mucolipidosis    metachromatic leukodystrophy    endometriosis    x-linked ichthyosis
    estrogen-receptor positive breast cancer    leukodystrophy    breast cyst    lysosomal storage disease
    autonomic dysfunction    gaucher's disease    gangliosidosis    gynecomastia

    5 diseases from the University of Copenhagen DISEASES database for ARSH:
    Mucopolysaccharidosis     Metachromatic leukodystrophy     X-linked ichthyosis     Mucosulfatidosis
    Breast cancer

    ARSH for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/33 Novoseek inferred disease relationships for ARSH gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple sulfatase deficiency 98.2 118 9336808 (4), 9880143 (4), 2127527 (3), 11315200 (3) (see all 50)
    leukodystrophy metachromatic 82.2 7 15446395 (1), 16600651 (1), 1687673 (1), 7584110 (1) (see all 6)
    mucopolysaccharidosis 78.1 8 12649064 (2), 2127527 (1), 11737681 (1), 10082381 (1) (see all 7)
    ichthyosis x-linked 77.8 2 1840419 (1), 18157819 (1)
    morquios syndrome 71.2 2 2127527 (1), 16133273 (1)
    maroteaux-lamy syndrome 71.2 4 2127527 (1), 1687673 (1), 8541342 (1)
    mps iiia 70 3 2127527 (1), 10561464 (1), 16600651 (1)
    chondrodysplasia punctata 69.2 3 17206939 (1), 15246527 (1)
    lysosomal storage diseases 69 9 1348358 (1), 17360554 (1), 14563551 (1), 10561464 (1) (see all 6)
    hunters syndrome 68.3 2 17206939 (1)


    Export disorders for ARSH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARSH gene, integrated from 9 sources (see all 307):
    (articles sorted by number of sources associating them with ARSH)
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    1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PubMed id 16174644)1, 2, 3, 9 Sardiello M....Ballabio A. (2005)
    2. SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies. (PubMed id 17206939)9 Fraldi A....Cosma M.P. (2007)
    3. Estrone sulfatase activity in patients with advanced ovarian cancer. (PubMed id 18947862)9 Chura J.C....Argenta P.A. (2009)
    4. Multiple sulfatase deficiency: catalytically inactive sulfatases are expressed from retrovirally introduced sulfatase cDNAs. (PubMed id 1348358)9 Rommerskirch W. and von Figura K. (1992)
    5. A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency. (PubMed id 7628016)9 Schmidt B.... von Figura K. (1995)
    6. Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency. (PubMed id 17360554)9 Settembre C....Ballabio A. (2007)
    7. Multiple sulfatase deficiency is due to hypomorphic mutations of the SUMF1 gene. (PubMed id 17657823)9 Annunziata I....Ballabio A. (2007)
    8. A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes. (PubMed id 16766528)9 Berteau O....Rabot S. (2006)
    9. Molecular and functional analysis of SUMF1 mutations in multiple sulfatase deficiency. (PubMed id 15146462)9 Cosma M.P.... Ballabio A. (2004)
    10. Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility. (PubMed id 15493058)9 Hanson S.R....Wong C.H. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 347527 HGNC: 32488 AceView: LOC347527 Ensembl:ENSG00000205667 euGenes: HUgn347527
    ECgene: ARSH H-InvDB: ARSH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARSH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARSH gene:
    Search GeneIP for patents involving ARSH

    GeneCards and IP:
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