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ARSH Gene

protein-coding   GIFtS: 48
GCID: GC0XP002919

Arylsulfatase Family, Member H

(Previous name: arylsulfatase H)
  See ARSH-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arylsulfatase Family, Member H1 2     EC 3.1.6.-3
Arylsulfatase H1 2     EC 3.1.68
ASH2 3     EC 3.1.6.28
sulfatase2     

External Ids:    HGNC: 324881   Entrez Gene: 3475272   Ensembl: ENSG000002056677   OMIM: 3005865   UniProtKB: Q5FYA83   

Export aliases for ARSH gene to outside databases

Previous GC identifer: GC0XP000867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARSH Gene:
Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and
glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of
macromolecules (Sardiello et al., 2005 (PubMed 16174644)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ARSH Gene:
ARSH (arylsulfatase family, member H) is a protein-coding gene. Diseases associated with ARSH include breast cyst, and ovarian endometriosis. GO annotations related to this gene include arylsulfatase activity. An important paralog of this gene is ARSF.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARSH gene promoter:
         p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARSH promoter sequence
   Search Chromatin IP Primers for ARSH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARSH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.33

ARSH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARSH gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP002919:  view genomic region     (about GC identifiers)

Start:
2,924,654 bp from pter      End:
2,951,612 bp from pter
Size:
26,959 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARSH_HUMAN, Q5FYA8 (See protein sequence)
Recommended Name: Arylsulfatase H  
Size: 562 amino acids; 63525 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)

Explore the universe of human proteins at neXtProt for ARSH: NX_Q5FYA8

Explore proteomics data for ARSH at MOPED

Post-translational modifications: 

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
  • Modification sites at neXtProt
  • Selected DME Specific Peptides for ARSH (Q5FYA8) (see all 6)
     NGIYKGG  HDPPLLFD  AFLTGRYP  HEFLFHYC 


    See ARSH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001011719.1  
    ENSEMBL proteins: 
     ENSP00000370522  
    Reactome Protein details: Q5FYA8

    ARSH Human Recombinant Protein Products:

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    Novus Biologicals ARSH Protein
    Novus Biologicals ARSH Lysate
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for ARSH

     
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    LSBio Antibodies in human, mouse, rat for ARSH

    ARSH Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARSH
    Cloud-Clone Corp. CLIAs for ARSH
    Search eBioscience for ELISAs for ARSH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARS: Arylsulfatase family

    4 InterPro protein domains:
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR000917 Sulfatase
     IPR024607 Sulfatase_CS
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q5FYA8

    ProtoNet protein and cluster: Q5FYA8

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: ARSH_HUMAN, Q5FYA8
    Similarity: Belongs to the sulfatase family


    Find genes that share domains with ARSH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.6.22 EC 3.1.62

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004065arylsulfatase activity TAS16174644
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ARSH           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARSH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARSH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARSH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARSH

    miRNA
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    Block miRNA regulation of human, mouse, rat ARSH using miScript Target Protectors
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    OriGene RNAi products in human, mouse, rat for ARSH
    Predesigned siRNA for gene silencing in human, mouse, rat ARSH

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSH

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARSH_HUMAN, Q5FYA8: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    lysosome3
    plasma membrane3
    cytosol2
    extracellular2
    golgi apparatus2
    vacuole2
    endosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ARSH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARSH About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Glycosphingolipid metabolism0.56
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    The activation of arylsulfatases0.00
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30


    Find genes that share SuperPaths with ARSH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for ARSH
        Glycosphingolipid metabolism
    The activation of arylsulfatases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARSH
    Interactions:

        GeneGlobe Interaction Network for ARSH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ARSH (ENSP000003705224) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSAENSP000002161244STRING: ENSP00000216124
    ARSBENSP000002649144STRING: ENSP00000264914
    ARSDENSP000003705464STRING: ENSP00000370546
    ARSEENSP000003705264STRING: ENSP00000370526
    ARSFENSP000003523194STRING: ENSP00000352319
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with ARSH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARSH

    1 HMDB Compound for ARSH    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for ARSH gene (see all 77)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    formylglycine 97 61 18305113 (4), 14563551 (3), 9497327 (3), 16399355 (2) (see all 28)
    estrone sulfate 90.3 25 2375600 (2), 8338787 (2), 2298851 (1), 12711003 (1) (see all 19)
    medrogestone 88.7 12 10529001 (2), 12227886 (1), 19179024 (1), 10419004 (1) (see all 11)
    promegestone 88.1 10 12227886 (1), 19179024 (1), 10862262 (1), 19962254 (1) (see all 10)
    p-nitrocatechol sulfate 88 1 8824834 (1)
    estrone 87.8 29 9009236 (3), 9096642 (2), 17064891 (2), 15302278 (1) (see all 22)
    17beta-hydroxysteroid 87.6 30 20204307 (4), 10862262 (2), 15274306 (2), 11384867 (2) (see all 22)
    nomegestrol acetate 86.9 15 16080533 (3), 15748827 (2), 12227886 (1), 19179024 (1) (see all 12)
    4-methylumbelliferyl sulfate 85.2 4 11177574 (2), 8920232 (1)
    1-menaphthyl sulfate 84.7 1 10548067 (1)



    Find genes that share compounds with ARSH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARSH gene: 
    NM_001011719.1  

    Unigene Cluster for ARSH:

    Arylsulfatase family, member H
    Hs.351533  [show with all ESTs]
    Unigene Representative Sequence: AY875940
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381130(uc011mhj.2)
    miRNA
    Products:
         
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat ARSH
    Clone
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    GenScript: all cDNA clones in your preferred vector: ARSH (NM_001011719)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ARSH
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ARSH
      QuantiTect SYBR Green Assays in human, mouse, rat ARSH
      QuantiFast Probe-based Assays in human, mouse, rat ARSH

    Additional mRNA sequence: AY875940.1 

    1 DOTS entry:

    DT.95307360 

    6 AceView cDNA sequences:

    CK904763 CK904764 AX801696 BM069810 BM069570 AI868403 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARSH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARSH Expression
    About this image

    ARSH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARSH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351533
        Custom PCR Arrays for ARSH
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARSH gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ARSH1 arylsulfatase family, member H 84.67(n)
    88.95(a)
      491720  NM_001048123.1  NP_001041588.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    many ↔ many
    3(114037137-114062932)
    zebrafish
    (Danio rerio)
    Actinopterygii arsh6
    arylsulfatase H
    49(a)
    1 → many
    9(57794391-57813088) ENSDARG00000002299
    worm
    (Caenorhabditis elegans)
    Secernentea sul-26
    Protein SUL-2 (sul-2) mRNA, complete cds
    30(a)
    1 → many
    V(8157746-8159874) WBGene00006309


    ENSEMBL Gene Tree for ARSH (if available)
    TreeFam Gene Tree for ARSH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARSH gene
    ARSF2  ARSI2  ARSJ2  ARSG2  ARSA2  STS2  ARSB2  GALNS2  
    ARSE2  ARSD2  
    5 SIMAP similar genes for ARSH using alignment to 1 protein entry:     ARSH_HUMAN:
    ARSD    ARSE    ARSF    STS    IDS

    Find genes that share paralogs with ARSH           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARSH (see all 595)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59394031,2
    C,A--2922687(+) GTTTCC/TTTTCT 1 -- us2k1 trp30--------
    rs1420190041,2
    C--2922907(+) CACAT-/ACAC  
            
    CACAC
    1 -- us2k10--------
    rs2019067811,2
    --2922924(+) ACACA-/CACC  
            
    CCTAT
    1 -- us2k10--------
    rs1402313981,2
    --2922925(+) CACACA/TCCCCT 1 -- us2k10--------
    rs1411683511,2
    --2923014(+) GGCGCA/GATCTT 1 -- us2k10--------
    rs1837865011,2
    --2923235(+) ACAGGC/TGCGTG 1 -- us2k10--------
    rs1124698151,2
    C,F--2923300(+) TGTCAA/GGCTGG 1 -- us2k12Minor allele frequency- G:0.33NA WA 3
    rs1877512001,2
    --2923375(+) ATGAGA/CCACTG 1 -- us2k10--------
    rs1911178801,2
    --2923377(+) GAGCCA/CCTGTG 1 -- us2k10--------
    rs1113814441,2
    C,F--2923439(+) TGAGAC/G/TAGGGT 1 -- us2k11NA 1

    HapMap Linkage Disequilibrium report for ARSH (2924654 - 2951612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARSH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674359CNV Deletion23128226
    esv33241CNV Loss17666407
    esv34985CNV Gain17911159
    dgv13n29CNV Gain16826518
    essv3621CNV CNV17122850
    dgv2432e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ARSH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARSH
    DNA2.0 Custom Variant and Variant Library Synthesis for ARSH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300586    OMIM disorders: --

    16 diseases for ARSH:    
    About MalaCards
    breast cyst    ovarian endometriosis    breast fibroadenoma    mucopolysaccharidosis vi
    autonomic dysfunction    mucosulfatidosis    metachromatic leukodystrophy    mucolipidosis ii
    mucolipidosis    beta-ketothiolase deficiency    endometriosis    ketothiolase deficiency
    x-linked ichthyosis    gaucher's disease    pancreatic cancer    breast cancer

    5 diseases from the University of Copenhagen DISEASES database for ARSH:
    Mucopolysaccharidosis     Metachromatic leukodystrophy     X-linked ichthyosis     Mucosulfatidosis
    Breast cancer

    Find genes that share disorders with ARSH           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ARSH gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple sulfatase deficiency 98.2 118 9336808 (4), 9880143 (4), 2127527 (3), 11315200 (3) (see all 50)
    leukodystrophy metachromatic 82.2 7 15446395 (1), 16600651 (1), 1687673 (1), 7584110 (1) (see all 6)
    mucopolysaccharidosis 78.1 8 12649064 (2), 2127527 (1), 11737681 (1), 10082381 (1) (see all 7)
    ichthyosis x-linked 77.8 2 1840419 (1), 18157819 (1)
    morquios syndrome 71.2 2 2127527 (1), 16133273 (1)
    maroteaux-lamy syndrome 71.2 4 2127527 (1), 1687673 (1), 8541342 (1)
    mps iiia 70 3 2127527 (1), 10561464 (1), 16600651 (1)
    chondrodysplasia punctata 69.2 3 17206939 (1), 15246527 (1)
    lysosomal storage diseases 69 9 1348358 (1), 17360554 (1), 14563551 (1), 10561464 (1) (see all 6)
    hunters syndrome 68.3 2 17206939 (1)


    Export disorders for ARSH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARSH gene, integrated from 10 sources (see all 307):
    (articles sorted by number of sources associating them with ARSH)
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    1. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PubMed id 16174644)1, 2, 3, 9 Sardiello M.... Ballabio A. (Hum. Mol. Genet. 2005)
    2. SUMF1 enhances sulfatase activities in vivo in five sulfatase deficiencies. (PubMed id 17206939)9 Fraldi A....Cosma M.P. (Biochem. J. 2007)
    3. Estrone sulfatase activity in patients with advanced ovarian cancer. (PubMed id 18947862)9 Chura J.C....Argenta P.A. (Gynecol. Oncol. 2009)
    4. Multiple sulfatase deficiency: catalytically inactive sulfatases are expressed from retrovirally introduced sulfatase cDNAs. (PubMed id 1348358)9 Rommerskirch W. and von Figura K. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    5. A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency. (PubMed id 7628016)9 Schmidt B.... von Figura K. (Cell 1995)
    6. Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency. (PubMed id 17360554)9 Settembre C....Ballabio A. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    7. Multiple sulfatase deficiency is due to hypomorphic mutations of the SUMF1 gene. (PubMed id 17657823)9 Annunziata I....Ballabio A. (Hum. Mutat. 2007)
    8. A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes. (PubMed id 16766528)9 Berteau O....Rabot S. (J. Biol. Chem. 2006)
    9. Molecular and functional analysis of SUMF1 mutations in multiple sulfatase deficiency. (PubMed id 15146462)9 Cosma M.P.... Ballabio A. (Hum. Mutat. 2004)
    10. Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility. (PubMed id 15493058)9 Hanson S.R....Wong C.H. (Angew. Chem. Int. Ed. Engl. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347527 HGNC: 32488 AceView: LOC347527 Ensembl:ENSG00000205667 euGenes: HUgn347527
    ECgene: ARSH H-InvDB: ARSH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARSH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARSH gene:
    Search GeneIP for patents involving ARSH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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