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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARSG Gene

protein-coding   GIFtS: 58
GCID: GC17P066255

Arylsulfatase G

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arylsulfatase G1 2
ASG2 3
KIAA10013 5
EC 3.1.6.-3
EC 3.1.68
EC 3.1.6.48

External Ids:    HGNC: 241021   Entrez Gene: 229012   Ensembl: ENSG000001413377   OMIM: 6100085   UniProtKB: Q96EG13   

Export aliases for ARSG gene to outside databases

Previous GC identifers: GC17P063767 GC17P061641


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARSG Gene:
The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from
sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis,
modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at
acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively
spliced transcript variants have been found for this gene. (provided by RefSeq, Jun 2012)

GeneCards Summary for ARSG Gene: 
ARSG (arylsulfatase G) is a protein-coding gene. Diseases associated with ARSG include metachromatic leukodystrophy, and leukodystrophy, and among its related super-pathways are Sphingolipid metabolism and The activation of arylsulfatases. GO annotations related to this gene include arylsulfatase activity and metal ion binding. An important paralog of this gene is ARSF.

UniProtKB/Swiss-Prot: ARSG_HUMAN, Q96EG1
Function: Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and
also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARSG gene promoter:
         SRF   C/EBPbeta   p53   ATF-2   SRF (504 AA)   Pax-6   AREB6   Max   c-Myc   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARSG promoter sequence
   Search SABiosciences Chromatin IP Primers for ARSG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARSG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24.2

ARSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARSG gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P066255:  view genomic region     (about GC identifiers)

Start:
66,255,323 bp from pter      End:
66,418,872 bp from pter
Size:
163,550 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARSG_HUMAN, Q96EG1 (See protein sequence)
Recommended Name: Arylsulfatase G precursor  
Size: 525 amino acids; 57061 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Lysosome. Note=Previously observed endoplasmic reticulum localization is most likely due to
folding/maturation problems for overexpressed proteins
Sequence caution: Sequence=BAA76845.2; Type=Erroneous initiation;
Secondary accessions: Q6UXF2 Q9Y2K4

Explore the universe of human proteins at neXtProt for ARSG: NX_Q96EG1

Explore proteomics data for ARSG at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • UniProtKB: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)
  • UniProtKB: Glycosylated
  • View neXtProt modification sites for NX_Q96EG1

  • 4 DME Specific Peptides for ARSG (Q96EG1)
     DDMGWGDLG  GLPLNETTLA  GDNGPWAQKCELAGS  KQTTWEGGHRVPALAYWPGRVP 

    ARSG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARSG Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001254656.1  NP_055775.2  

    ENSEMBL proteins: 
     ENSP00000407193   ENSP00000462306   ENSP00000413953  
    Reactome Protein details: Q96EG1
    Human Recombinant Protein Products for ARSG: 
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    Novus Biologicals ARSG Proteins
    Novus Biologicals ARSG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ARSG
    Cloud-Clone Corp. Proteins for ARSG 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA18283100
    GO:0005764lysosome IDA18283100
    GO:0005783endoplasmic reticulum IDA12461688
    GO:0005788endoplasmic reticulum lumen TAS--

    ARSG for ontologies           About GeneDecksing



    ARSG Antibody Products: 
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    Cloud-Clone Corp. CLIAs for ARSG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARS: Arylsulfatase family

    4 InterPro protein domains:
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024607 Sulfatase_CS
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q96EG1

    ProtoNet protein and cluster: Q96EG1

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: ARSG_HUMAN, Q96EG1
    Similarity: Belongs to the sulfatase family


    ARSG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARSG_HUMAN, Q96EG1
    Function: Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and
    also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate
    Enzyme regulation: Inhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine
    Biophysicochemical properties: Kinetic parameters: KM=4.2 mM for p-nitrocatechol sulfate; Vmax=63.5 umol/min/mg
    enzyme toward p-nitrocatechol sulfate; pH dependence: Optimum pH is 5.4; Temperature dependence: Most efficient
    at 45-50 degrees Celsius;

         Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.62 EC 3.1.6.42

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004065arylsulfatase activity TAS16174644
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    ARSG for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARSG:
     Increased cell number in G2M,  

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arsg):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  nervous system  renal/urinary system 

    ARSG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arsgtm1Tdi for ARSG

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARSG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARSG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARSG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARSG 

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    Inhib. RNA
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    Clone
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    Sino Biological Human cDNA Clone for ARSG
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                         Customized lentivirus expression plasmids for stable overexpression of ARSG 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARSG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.63
    Glycosphingolipid metabolism0.55
    2PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation0.46
    The activation of arylsulfatases0.46
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    5Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/8        Reactome Pathways for ARSG (see all 8)
        Sphingolipid metabolism
    Glycosphingolipid metabolism
    Metabolism
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    Metabolism of proteins


    1         Kegg Pathway  (Kegg details for ARSG):
        Lysosome


    ARSG for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARSG

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0006790sulfur compound metabolic process IDA18283100
    GO:0008152metabolic process ----
    GO:0043687post-translational protein modification TAS--

    ARSG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARSG

    1 HMDB Compound for ARSG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about ARSG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARSG gene (2 alternative transcripts): 
    NM_001267727.1  NM_014960.4  

    Unigene Cluster for ARSG:

    Arylsulfatase G
    Hs.437249  [show with all ESTs]
    Unigene Representative Sequence: NM_014960
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448504(uc002jhc.2) ENST00000578726 ENST00000581639 ENST00000452479
    ENST00000582154 ENST00000581032 ENST00000578554(uc010dex.1) ENST00000590690

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ARSG
    SwitchGear 3'UTR luciferase reporter plasmidARSG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARSG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARSG
    Clone
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    OriGene ORF clones in mouse, rat for ARSG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARSG (NM_014960)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSG
    Sirion Biotech Customized lentivirus for stable overexpression of ARSG 
                         Customized lentivirus expression plasmids for stable overexpression of ARSG 
    Primer
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    OriGene qPCR primer pairs and template standards for ARSG
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARSG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARSG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSG

    Additional mRNA sequence: 

    AK311327.1 AY358380.1 BC012375.1 

    9 DOTS entries:

    DT.408467  DT.121009751  DT.100771720  DT.40110154  DT.100016235  DT.75125514  DT.95345368  DT.95365674 
    DT.91729779 

    24/78 AceView cDNA sequences (see all 78):

    AU185991 BF588559 BC012375 AI419226 NM_014960 BQ052348 CR593524 AI184471 
    CB049237 AA928517 Z28591 BU621299 AI268878 AI423178 CA436442 CA308403 
    AW015018 CO250133 BI259988 H41712 AW014241 BQ640672 BX095687 BQ052805 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARSG expression in normal human tissues (normalized intensities)      ARSG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATGCCTG
    ARSG Expression
    About this image


    ARSG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Fourth Ventricle
             brain/forebrain/telencephalon   
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule

    See ARSG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARSG

    SOURCE GeneReport for Unigene cluster: Hs.437249

    UniProtKB/Swiss-Prot: ARSG_HUMAN, Q96EG1
    Tissue specificity: Widely expressed, with very low expression in brain, lung, heart and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARSG gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arsg1 , 5 arylsulfatase G1, 5 81.9(n)1
    82.79(a)1
      11 (71.98 cM)5
    740081  NM_028710.31  NP_082986.31 
     1094733745 
    chicken
    (Gallus gallus)
    Aves ARSG1 arylsulfatase G 68.21(n)
    67.87(a)
      427811  XM_425382.2  XP_425382.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARSG6
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL343260.1(1477246-1625236)
    zebrafish
    (Danio rerio)
    Actinopterygii arsg1 arylsulfatase G 59.46(n)
    58.42(a)
      564790  NM_001089405.1  NP_001082874.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sul-26
    Protein SUL-2
    25(a)
    1 → many
    V(8157746-8159874)


    ENSEMBL Gene Tree for ARSG (if available)
    TreeFam Gene Tree for ARSG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARSG gene
    ARSF2  ARSI2  ARSJ2  ARSA2  STS2  ARSH2  ARSB2  GALNS2  
    ARSE2  ARSD2  
    3 SIMAP similar genes for ARSG using alignment to 3 protein entries:     ARSG_HUMAN (see all proteins):
    GALNS    ARSA    DKFZp686G12235

    ARSG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3559 SNPs in ARSG are shown (see all 3559)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs354460891,2
    C--66258312(+) CAAAC-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs2003457471,2
    C--66258312(+) CAAAC-/AA/C  
            
    AAAAA
    1 -- int10--------
    rs58216481,2
    C,F--66259382(+) TCATTA/-ACGAG 1 -- int13Minor allele frequency- -:0.33NA CSA 6
    rs1137822091,2
    C,F--66260824(+) CCACCC/TGCCTT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1129516161,2
    C--66261250(+) AGATCG/ACGCCA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1136527911,2
    F--66261383(+) TAATCG/CCAGCA 1 -- int12Minor allele frequency- C:0.50CSA 4
    rs1116638031,2
    F--66261414(+) CAGATC/AACTTG 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs113680111,2
    C--66261854(+) CACTGT/-TTTTT 1 -- int1 trp31Minor allele frequency- -:0.50NA 2
    rs563556261,2
    C--66261907(+) TTTTT-/T/TT  
            
    AACAT
    1 -- int10--------
    rs105664091,2
    C--66264568(+) CAAGT-/TATATAT 1 -- int11Minor allele frequency- TA:0.00NA 2

    HapMap Linkage Disequilibrium report for ARSG (66255323 - 66418872 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARSG:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673940CNV Deletion23128226
    nsv908692CNV Loss21882294
    nsv833523CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610008    OMIM disorders: --

    5 diseases for ARSG:    About MalaCards
    metachromatic leukodystrophy    leukodystrophy    neuronal ceroid lipofuscinosis    tuberculosis
    neuronitis


    ARSG for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARSG
    Human Genome Epidemiology (HuGE) Navigator: ARSG (2 documents)

    Export disorders for ARSG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARSG gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ARSG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular and biochemical characterisation of a novel sulphatase gene: arylsulfatase G (ARSG). (PubMed id 12461688)1, 2, 3, 9 Ferrante P.... Ballabio A. (2002)
    2. Arylsulfatase G, a novel lysosomal sulfatase. (PubMed id 18283100)1, 2, 9 Frese M.A.... Dierks T. (2008)
    3. Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loc i are related to blood pressure and/or hypertension in two Korean cohorts. (PubMed id 19960030)1, 4 Hong K.W....Oh B. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PubMed id 16174644)1, 3 Sardiello M....Ballabio A. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    9. A genome-wide association study of sporadic ALS in a homogenous Irish population. (PubMed id 18057069)4 Cronin S....Hardiman O. (2008)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22901 HGNC: 24102 AceView: KIAA1001 Ensembl:ENSG00000141337 euGenes: HUgn22901
    ECgene: ARSG Kegg: 22901 H-InvDB: ARSG

    (According to HUGE)
    About This Section
    HUGE: KIAA1001

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARSG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARSG gene:
    Search GeneIP for patents involving ARSG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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