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Aliases for ARSG Gene

Aliases for ARSG Gene

  • Arylsulfatase G 2 3 5
  • ASG 3 4
  • EC 63
  • EC 3.1.6.- 4
  • KIAA1001 4
  • EC 3.1.6 63

External Ids for ARSG Gene

Previous GeneCards Identifiers for ARSG Gene

  • GC17P063767
  • GC17P066255
  • GC17P061641

Summaries for ARSG Gene

Entrez Gene Summary for ARSG Gene

  • The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for ARSG Gene

ARSG (Arylsulfatase G) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is ARSJ.

UniProtKB/Swiss-Prot for ARSG Gene

  • Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSG Gene

Genomics for ARSG Gene

Regulatory Elements for ARSG Gene

Enhancers for ARSG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARSG on UCSC Golden Path with GeneCards custom track

Genomic Location for ARSG Gene

68,257,159 bp from pter
68,450,773 bp from pter
193,615 bases
Plus strand

Genomic View for ARSG Gene

Genes around ARSG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARSG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSG Gene

Proteins for ARSG Gene

  • Protein details for ARSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylsulfatase G
    Protein Accession:
    Secondary Accessions:
    • Q6UXF2
    • Q9Y2K4

    Protein attributes for ARSG Gene

    525 amino acids
    Molecular mass:
    57061 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=BAA76845.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ARSG Gene

Proteomics data for ARSG Gene at MOPED

Selected DME Specific Peptides for ARSG Gene

Post-translational modifications for ARSG Gene

  • Glycosylated.
  • N-glycosylated.
  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn 117, Asn 215, Asn 356, and Asn 497
  • Modification sites at PhosphoSitePlus

Other Protein References for ARSG Gene

Antibody Products

  • R&D Systems Antibodies for ARSG (Arylsulfatase G/ARSG)

Domains & Families for ARSG Gene

Gene Families for ARSG Gene

Protein Domains for ARSG Gene

Suggested Antigen Peptide Sequences for ARSG Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the sulfatase family.
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSG: view

Function for ARSG Gene

Molecular function for ARSG Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.2 mM for p-nitrocatechol sulfate {ECO:0000269 PubMed:18283100}; Vmax=63.5 umol/min/mg enzyme toward p-nitrocatechol sulfate {ECO:0000269 PubMed:18283100}; pH dependence: Optimum pH is 5.4. {ECO:0000269 PubMed:18283100}; Temperature dependence: Most efficient at 45-50 degrees Celsius. {ECO:0000269 PubMed:18283100};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine.
UniProtKB/Swiss-Prot Function:
Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate.

Enzyme Numbers (IUBMB) for ARSG Gene

genes like me logo Genes that share phenotypes with ARSG: view

Animal Models for ARSG Gene

MGI Knock Outs for ARSG:

Animal Model Products

  • Taconic Biosciences Mouse Models for ARSG

miRNA for ARSG Gene

miRTarBase miRNAs that target ARSG

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARSG Gene

Localization for ARSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSG Gene

Lysosome. Note=Previously observed endoplasmic reticulum localization is most likely due to folding/maturation problems for overexpressed proteins.

Subcellular locations from

Jensen Localization Image for ARSG Gene COMPARTMENTS Subcellular localization image for ARSG gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
lysosome 5
vacuole 5
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12461688
genes like me logo Genes that share ontologies with ARSG: view

Pathways & Interactions for ARSG Gene

genes like me logo Genes that share pathways with ARSG: view

Interacting Proteins for ARSG Gene

Gene Ontology (GO) - Biological Process for ARSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006790 sulfur compound metabolic process IDA 18283100
GO:0008152 metabolic process IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ARSG: view

No data available for SIGNOR curated interactions for ARSG Gene

Drugs & Compounds for ARSG Gene

(1) Drugs for ARSG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with ARSG: view

Transcripts for ARSG Gene

Unigene Clusters for ARSG Gene

Arylsulfatase G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARSG Gene

No ASD Table

Relevant External Links for ARSG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARSG Gene

mRNA expression in normal human tissues for ARSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARSG Gene

This gene is overexpressed in Whole Blood (x6.6).

Protein differential expression in normal tissues from HIPED for ARSG Gene

This gene is overexpressed in Serum (47.7) and Urine (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARSG Gene

SOURCE GeneReport for Unigene cluster for ARSG Gene Hs.437249

mRNA Expression by UniProt/SwissProt for ARSG Gene

Tissue specificity: Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.
genes like me logo Genes that share expression patterns with ARSG: view

Protein tissue co-expression partners for ARSG Gene

Primer Products

Orthologs for ARSG Gene

This gene was present in the common ancestor of animals.

Orthologs for ARSG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARSG 35
  • 75.33 (n)
  • 80 (a)
  • 85 (a)
(Canis familiaris)
Mammalia ARSG 35
  • 85.81 (n)
  • 86.83 (a)
  • 85 (a)
(Mus musculus)
Mammalia Arsg 35
  • 81.9 (n)
  • 82.79 (a)
Arsg 16
Arsg 36
  • 82 (a)
(Pan troglodytes)
Mammalia ARSG 35
  • 99.43 (n)
  • 99.62 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arsg 35
  • 82.09 (n)
  • 83.94 (a)
(Monodelphis domestica)
Mammalia ARSG 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
(Gallus gallus)
Aves ARSG 35
  • 67.93 (n)
  • 67.53 (a)
  • 60 (a)
(Anolis carolinensis)
Reptilia ARSG 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arsg 35
  • 61.92 (n)
  • 60.68 (a)
(Danio rerio)
Actinopterygii arsg 35
  • 58.76 (n)
  • 57.06 (a)
arsg 36
  • 55 (a)
(Caenorhabditis elegans)
Secernentea sul-2 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for ARSG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARSG Gene

Gene Tree for ARSG (if available)
Gene Tree for ARSG (if available)

Paralogs for ARSG Gene

Paralogs for ARSG Gene

(3) SIMAP similar genes for ARSG Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARSG: view

Variants for ARSG Gene

Sequence variations from dbSNP and Humsavar for ARSG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8074806 - 68,307,525(+) GTTGG(C/T)GGGAG nc-transcript-variant, reference, missense
rs1558876 - 68,368,550(+) CAGCA(C/G)CAGCG nc-transcript-variant, reference, missense, splice-acceptor-variant, utr-variant-5-prime
rs1558878 - 68,368,663(+) GGCTC(C/T)GGGAG nc-transcript-variant, reference, missense
rs9972951 - 68,395,135(+) ACGGC(A/G)CTTTG intron-variant, nc-transcript-variant, reference, missense
VAR_074038 -

Structural Variations from Database of Genomic Variants (DGV) for ARSG Gene

Variant ID Type Subtype PubMed ID
nsv908692 CNV Loss 21882294
esv2673940 CNV Deletion 23128226
nsv833523 CNV Gain 17160897

Variation tolerance for ARSG Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.88; 93.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARSG Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARSG Gene

Disorders for ARSG Gene

Relevant External Links for ARSG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARSG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARSG Gene

Publications for ARSG Gene

  1. Molecular and biochemical characterisation of a novel sulphatase gene: arylsulfatase G (ARSG). (PMID: 12461688) Ferrante P. … Ballabio A. (Eur. J. Hum. Genet. 2002) 2 3 4 23 67
  2. Arylsulfatase G, a novel lysosomal sulfatase. (PMID: 18283100) Frese M.A. … Dierks T. (J. Biol. Chem. 2008) 3 23
  3. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PMID: 16174644) Sardiello M. … Ballabio A. (Hum. Mol. Genet. 2005) 2 3
  4. Accumulation of rare variants in the arylsulfatase G (ARSG) gene in task-specific dystonia. (PMID: 25825126) Nibbeling E. … Lohmann K. (J. Neurol. 2015) 3
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3

Products for ARSG Gene

Sources for ARSG Gene