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Aliases for ARSG Gene

Aliases for ARSG Gene

  • Arylsulfatase G 2 3
  • KIAA1001 4 6
  • ASG 3 4
  • EC 3.1.6.4 64
  • EC 3.1.6.- 4
  • EC 3.1.6 64

External Ids for ARSG Gene

Summaries for ARSG Gene

Entrez Gene Summary for ARSG Gene

  • The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for ARSG Gene

ARSG (Arylsulfatase G) is a Protein Coding gene. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include arylsulfatase activity. An important paralog of this gene is ARSJ.

UniProtKB/Swiss-Prot for ARSG Gene

  • Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSG Gene

Genomics for ARSG Gene

Genomic Location for ARSG Gene

Start:
68,259,182 bp from pter
End:
68,440,769 bp from pter
Size:
181,588 bases
Orientation:
Plus strand

Genomic View for ARSG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSG Gene

Regulatory Elements for ARSG Gene

Proteins for ARSG Gene

  • Protein details for ARSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EG1-ARSG_HUMAN
    Recommended name:
    Arylsulfatase G
    Protein Accession:
    Q96EG1
    Secondary Accessions:
    • Q6UXF2
    • Q9Y2K4

    Protein attributes for ARSG Gene

    Size:
    525 amino acids
    Molecular mass:
    57061 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76845.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ARSG Gene

Proteomics data for ARSG Gene at MOPED

Selected DME Specific Peptides for ARSG Gene

Post-translational modifications for ARSG Gene

  • Glycosylated
  • N-glycosylated
  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn117, Asn215, Asn356, and Asn497

Other Protein References for ARSG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ARSG Gene

Gene Families for ARSG Gene

HGNC:
  • ARS :Arylsulfatase family

Protein Domains for ARSG Gene

UniProtKB/Swiss-Prot:

ARSG_HUMAN
Family:
  • Belongs to the sulfatase family.:
    • Q96EG1
genes like me logo Genes that share domains with ARSG: view

Function for ARSG Gene

Molecular function for ARSG Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=4.2 mM for p-nitrocatechol sulfate {ECO:0000269 PubMed:18283100}; Vmax=63.5 umol/min/mg enzyme toward p-nitrocatechol sulfate {ECO:0000269 PubMed:18283100}; pH dependence: Optimum pH is 5.4. {ECO:0000269 PubMed:18283100}; Temperature dependence: Most efficient at 45-50 degrees Celsius. {ECO:0000269 PubMed:18283100};
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine
UniProtKB/Swiss-Prot Function: Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate.

Enzyme Numbers (IUBMB) for ARSG Gene

Gene Ontology (GO) - Molecular Function for ARSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004065 arylsulfatase activity TAS 16174644
GO:0008484 sulfuric ester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARSG: view
genes like me logo Genes that share phenotypes with ARSG: view

Animal Models for ARSG Gene

MGI Knock Outs for ARSG:

miRNA for ARSG Gene

miRTarBase miRNAs that target ARSG

No data available for Transcription Factor Targeting and HOMER Transcription for ARSG Gene

Localization for ARSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSG Gene

Lysosome. Note=Previously observed endoplasmic reticulum localization is most likely due to folding/maturation problems for overexpressed proteins.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARSG Gene COMPARTMENTS Subcellular localization image for ARSG gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
endoplasmic reticulum 4
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18283100
GO:0005764 lysosome IDA 18283100
GO:0005783 endoplasmic reticulum IDA 12461688
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with ARSG: view

Pathways for ARSG Gene

genes like me logo Genes that share pathways with ARSG: view

Interacting Proteins for ARSG Gene

Gene Ontology (GO) - Biological Process for ARSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0006790 sulfur compound metabolic process IDA 18283100
GO:0008152 metabolic process --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ARSG: view

Compounds for ARSG Gene

(1) HMDB Compounds for ARSG Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with ARSG: view

Transcripts for ARSG Gene

Unigene Clusters for ARSG Gene

Arylsulfatase G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARSG Gene

No ASD Table

Relevant External Links for ARSG Gene

GeneLoc Exon Structure for
ARSG
ECgene alternative splicing isoforms for
ARSG

Expression for ARSG Gene

mRNA expression in normal human tissues for ARSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARSG Gene

This gene is overexpressed in Whole Blood (6.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ARSG Gene

SOURCE GeneReport for Unigene cluster for ARSG Gene Hs.437249

mRNA Expression by UniProt/SwissProt for ARSG Gene

Q96EG1-ARSG_HUMAN
Tissue specificity: Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.
genes like me logo Genes that share expressions with ARSG: view

Orthologs for ARSG Gene

This gene was present in the common ancestor of animals.

Orthologs for ARSG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARSG 36
  • 99.43 (n)
  • 99.62 (a)
ARSG 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARSG 36
  • 75.33 (n)
  • 80 (a)
ARSG 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARSG 36
  • 85.81 (n)
  • 86.83 (a)
ARSG 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arsg 36
  • 81.9 (n)
  • 82.79 (a)
Arsg 16
Arsg 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARSG 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 29 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Arsg 36
  • 82.09 (n)
  • 83.94 (a)
chicken
(Gallus gallus)
Aves ARSG 36
  • 67.93 (n)
  • 67.53 (a)
ARSG 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARSG 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arsg 36
  • 61.92 (n)
  • 60.68 (a)
zebrafish
(Danio rerio)
Actinopterygii arsg 36
  • 58.76 (n)
  • 57.06 (a)
arsg 37
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sul-2 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToOne
Species with no ortholog for ARSG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARSG Gene

ENSEMBL:
Gene Tree for ARSG (if available)
TreeFam:
Gene Tree for ARSG (if available)

Paralogs for ARSG Gene

Paralogs for ARSG Gene

Selected SIMAP similar genes for ARSG Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARSG: view

Variants for ARSG Gene

Sequence variations from dbSNP and Humsavar for ARSG Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs740452 -- 68,316,097(-) aaaca(C/T)gtgca intron-variant
rs740453 -- 68,315,963(-) TCAAC(C/G)ATTTT intron-variant
rs758151 -- 68,316,045(-) TAGGC(A/G)GGATA intron-variant
rs758152 -- 68,315,191(-) CCCCA(A/G)TTCTG intron-variant
rs1007041 -- 68,388,413(+) cagac(A/T)gtgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARSG Gene

Variant ID Type Subtype PubMed ID
nsv908692 CNV Loss 21882294
esv2673940 CNV Deletion 23128226
nsv833523 CNV Gain 17160897

Relevant External Links for ARSG Gene

HapMap Linkage Disequilibrium report
ARSG

Disorders for ARSG Gene

Relevant External Links for ARSG

Genetic Association Database (GAD)
ARSG
Human Genome Epidemiology (HuGE) Navigator
ARSG
genes like me logo Genes that share disorders with ARSG: view

No data available for UniProtKB/Swiss-Prot for ARSG Gene

Publications for ARSG Gene

  1. Molecular and biochemical characterisation of a novel sulphatase gene: arylsulfatase G (ARSG). (PMID: 12461688) Ferrante P. … Ballabio A. (Eur. J. Hum. Genet. 2002) 2 3 4 23
  2. Arylsulfatase G, a novel lysosomal sulfatase. (PMID: 18283100) Frese M.A. … Dierks T. (J. Biol. Chem. 2008) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARSG Gene

  • Addgene plasmids for ARSG

Sources for ARSG Gene

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