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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARSG Gene

protein-coding   GIFtS: 53
GCID: GC17P066255

arylsulfatase G
 Explore 8 diseases affiliated with
ARSG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARSG    

Aliases
for ARSG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Arylsulfatase G1 2
KIAA10011 3 5
ASG2 3
EC 3.1.6.-3
EC 3.1.68
EC 3.1.6.48

External Ids:    HGNC: 241021   Entrez Gene: 229012   Ensembl: ENSG000001413377   OMIM: 6100085   UniProtKB: Q96EG13   

Export aliases for ARSG gene to outside databases

Previous GC identifers: GC17P063767 GC17P061641


Summaries
for ARSG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARSG:
The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from
sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis,
modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at
acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively
spliced transcript variants have been found for this gene. (provided by RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: ARSG_HUMAN, Q96EG1
Function: Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also,
but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate




Genomic Views
for ARSG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARSG gene promoter:
         SRF   C/EBPbeta   p53   ATF-2   SRF (504 AA)   Pax-6   AREB6   Max   c-Myc   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARSG promoter sequence
   Search SABiosciences Chromatin IP Primers for ARSG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARSG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q24.2   Ensembl cytogenetic band:  17q24.2   HGNC cytogenetic band: 17q24

ARSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARSG gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P066255:  view genomic region     (about GC identifiers)

Start:
 66,255,323 bp from pter      End:
 66,418,872 bp from pter
Size:
 163,550 bases      Orientation:
 plus strand

Proteins
for ARSG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARSG_HUMAN, Q96EG1 (See protein sequence)
Recommended Name: Arylsulfatase G precursor  
Size: 525 amino acids; 57061 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Lysosome. Note=Previously observed endoplasmic reticulum localization is most likely due to
folding/maturation problems for overexpressed proteins
Sequence caution: Sequence=BAA76845.2; Type=Erroneous initiation;
Secondary accessions: Q6UXF2 Q9Y2K4

Explore the universe of human proteins at neXtProt for ARSG: NX_Q96EG1

Post-translational modifications:

  • N-glycosylated1
  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes
    • and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
  • Glycosylated1
  • View neXtProt modification sites for NX_Q96EG1

    • 4 DME Specific Peptides for ARSG (Q96EG1)
     DDMGWGDLG  GLPLNETTLA  GDNGPWAQKCELAGS  KQTTWEGGHRVPALAYWPGRVP 

    ARSG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001254656.1  NP_055775.2  

    ENSEMBL proteins: 
     ENSP00000407193   ENSP00000462306   ENSP00000413953  
    Reactome Protein details: Q96EG1
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: ARSG
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    Novus Biologicals ARSG Protein
    Novus Biologicals ARSG Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARSG

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA18283100
    GO:0005764lysosome IDA18283100
    GO:0005783endoplasmic reticulum IDA12461688
    GO:0005788endoplasmic reticulum lumen TAS--


    ARSG for ontologies           About GeneDecksing



    ARSG Antibody Products: 
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    Search ThermoFisher Antibodies for ARSG

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    Uscn ELISAs and CLIAs for ARSG

    Protein Domains /
    Families
    for ARSG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARSG for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024607 Sulfatase_CS
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry Q96EG1

    ProtoNet protein and cluster: Q96EG1

    1 Blocks protein family: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: ARSG_HUMAN, Q96EG1
    Similarity: Belongs to the sulfatase family


    Function
    for ARSG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARSG_HUMAN, Q96EG1
    Function: Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also,
    but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate
    Enzyme regulation: Inhibited by phosphate. The phosphate forms a covalent bond with the active site 3-oxoalanine
    Biophysicochemical properties: Kinetic parameters: KM=4.2 mM for p-nitrocatechol sulfate; Vmax=63.5 umol/min/mg enzyme
    toward p-nitrocatechol sulfate; pH dependence: Optimum pH is 5.4; Temperature dependence: Most efficient at 45-50
    degrees Celsius;

    Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.62 EC 3.1.6.42

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ARSG
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARSG
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ARSG
    SwitchGear 3'UTR luciferase reporter plasmid: ARSG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARSG (see all 7)
    OriGene shRNA RFP: ARSG
    OriGene siRNA: ARSG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARSG

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARSG

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARSG (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARSG (NM_014960)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSG 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ARSG
    Search LifeMap BioReagents cell lines for ARSG

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSG

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004065arylsulfatase activity TAS16174644
    GO:0046872metal ion binding IEA--


    ARSG for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ARSG:
     Increased cell number in G2M,  

    Animal Models:
         Mouse knock-out Arsgtm1Tdi for ARSG
         9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Arsg):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  nervous system  renal/urinary system 

    ARSG for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARSG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sphingolipid metabolism
    		Sphingolipid metabolism1.00
    		Glycosphingolipid metabolism0.54
    2PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    		PTM: gamma carboxylation, hypusine formation and arylsulfatase activation1.00
    		The activation of arylsulfatases0.46
    3Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    4Asparagine N-linked glycosylation
    		Post-translational protein modification0.44
    		Metabolism of proteins0.15
    5Lysosome
    		Lysosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for ARSG (see all 8)
        Sphingolipid metabolism
    Glycosphingolipid metabolism
    Metabolism
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    Metabolism of proteins


    1         Kegg Pathway  (Kegg details for ARSG):
        Lysosome


    ARSG for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARSG

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0006790sulfur compound metabolic process IDA18283100
    GO:0043687post-translational protein modification TAS--


    ARSG for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARSG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARSG

    1 HMDB Compound for ARSG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about ARSG 

    Transcripts
    for ARSG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARSG gene (2 alternative transcripts): 
    NM_001267727.1  NM_014960.4  

    Unigene Cluster for ARSG:

    Arylsulfatase G
    Hs.437249  [show with all ESTs]
    Unigene Representative Sequence: NM_014960
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448504(uc002jhc.2) ENST00000578726 ENST00000581639 ENST00000452479
    ENST00000582154 ENST00000581032 ENST00000578554(uc010dex.1) ENST00000590690


    miRNA
    Products:             		 OriGene 3'-UTR Clone: ARSG
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARSG
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ARSG
    SwitchGear 3'UTR luciferase reporter plasmid: ARSG 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARSG (see all 7)
    OriGene shRNA RFP: ARSG
    OriGene siRNA: ARSG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARSG
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARSG
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    GenScript: all cDNA clones in your preferred vector: ARSG (NM_014960)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSG 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARSG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARSG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSG

    Additional cDNA sequence: 

    AK311327.1 AY358380.1 BC012375.1 

    9 DOTS entries:

    DT.408467  DT.121009751  DT.100771720  DT.40110154  DT.100016235  DT.75125514  DT.95345368  DT.95365674 
    DT.91729779 

    24/78 AceView cDNA sequences (see all 78):

    Z28591 CA308403 AU185991 CR593524 CA436442 BQ052348 AI419226 NM_014960 
    BF588559 CB049237 BU621299 AI184471 AA928517 AI423178 AW015018 BC012375 
    AI268878 BX095687 BI254574 BF924594 AA234538 AA232239 BI553569 BU844715 

    GeneLoc Exon Structure


    Expression
    for ARSG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARSG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAATGCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARSG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusBrain
    BrainFourth VentricleBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARSG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARSG

    SOURCE GeneReport for Unigene cluster: Hs.437249

    UniProtKB/Swiss-Prot: ARSG_HUMAN, Q96EG1
    Tissue specificity: Widely expressed, with very low expression in brain, lung, heart and skeletal muscle

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSG

    Orthologs
    for ARSG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ARSG gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARSG1 arylsulfatase G 68.21(n)
    67.87(a)    		   427811  XM_425382.2  XP_425382.2 
    lizard
    (Anolis carolinensis)    		 Reptilia ARSG6
    --
    		 --
    		 67(a)
    43(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343260.1(1514906-1625236)
    GL344984.1(10385-13196)
    zebrafish
    (Danio rerio)    		 Actinopterygii arsg1 arylsulfatase G 59.46(n)
    58.42(a)    		   564790  NM_001089405.1  NP_001082874.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea sul-26
    		 SULfatase domain protein family member (sul-2)
    		 24(a)
    		 possible ortholog
    		 V(8157726-8159854)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria aslA6
    ydeN6
    		 conserved protein
    		 17(a)
    16(a)
    		 1 ↔ many
    possible ortholog
    		 Chromosome(3982375-3984030)
    Chromosome(1578866-1580548)


    ENSEMBL Gene Tree for ARSG (if available)
    TreeFam Gene Tree for ARSG (if available) 

    Paralogs
    for ARSG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARSG gene
    ARSF2  ARSJ2  ARSI2  ARSA2  ARSH2  STS2  ARSB2  GALNS2  
    ARSE2  ARSD2  
    3 SIMAP similar genes for ARSG using alignment to 3 protein entries:     ARSG_HUMAN (see all proteins):
    GALNS    ARSA    DKFZp686G12235

    ARSG for paralogs           About GeneDecksing



    Genomic Variants
    for ARSG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2521 NCBI SNPs in ARSG are shown (see all 2521)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1396556141,2
    		--66253407(+) AGTAAA/GTAACT 7 -- ds5001 us2k10--------
    rs1821115901,2
    		--66253425(+) GAACCA/GTTCAA 7 -- ds5001 us2k10--------
    rs1853152331,2
    		--66253489(+) GAGCCA/GCTCCC 7 -- us2k1 ds50010--------
    rs720823391,2
    		C,--66253545(+) CTGAT-/CACCACAG 7 -- ds5001 us2k10--------
    rs1114497611,2
    		--66253677(+) AAATAT/CGACCT 7 -- us2k1 ds50013Minor allele frequency- C:0.06CSA WA 121
    rs98927761,2
    		C,F,A,H,--66253696(+) TATTTA/GCAAGT 7 -- us2k1 ds50015Minor allele frequency- G:0.40NA 10
    rs1450036321,2
    		--66253727(+) CACTAC/GCACAA 7 -- ds5001 us2k10--------
    rs1909063131,2
    		--66253787(+) TTATGA/GGGGAT 7 -- ds5001 us2k10--------
    rs1833270571,2
    		--66253794(+) GGATCC/TTACAA 7 -- us2k1 ds50010--------
    rs99049341,2
    		C,--66253820(+) ATTTAC/TATTTG 1 -- us2k1 tfbs31Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for ARSG (66255323 - 66418872 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARSG: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARSG
    DNA2.0 Custom Variant and Variant Library Synthesis for ARSG

    Disorders / Diseases
    for ARSG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARSG for disorders           About GeneDecksing

    OMIM gene information: 610008    OMIM disorders: --

    8 diseases for ARSG:    About MalaCards
    ceroid lipofuscinosis    neuronal ceroid-lipofuscinosis    metachromatic leukodystrophy    leukodystrophy
    hypertension    tuberculosis    neuronitis    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: ARSG (2 documents)

    Export disorders for ARSG gene to outside databases

    Publications
    for ARSG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARSG gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARSG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular and biochemical characterisation of a novel sulphatase gene: arylsulfatase G (ARSG). (PubMed id 12461688)1, 2, 3, 9 Ferrante P.... Ballabio A. (2002)
    2. Arylsulfatase G, a novel lysosomal sulfatase. (PubMed id 18283100)1, 2, 9 Frese M.A.... Dierks T. (2008)
    3. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. (PubMed id 16174644)1, 3 Sardiello M....Ballabio A. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    7. Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loc i are related to blood pressure and/or hypertension in two Korean cohorts. (PubMed id 19960030)1 Hong K.W....Oh B. (2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Expression patterns of sulfatase genes in the develop ing mouse embryo. (PubMed id 20503373)9 Ratzka A....Vortkamp A. (2010)

    External Searches for ARSG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ARSG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22901 HGNC: 24102 AceView: KIAA1001 Ensembl:ENSG00000141337 euGenes: HUgn22901
    ECgene: ARSG Kegg: 22901 H-InvDB: ARSG

    Other Databases showing ARSG gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1001

    Specialized Databases showing ARSG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARSG Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARSG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARSG gene:
    Search GeneIP for patents involving ARSG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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