ARSF Gene
protein-coding GIFtS: 59
GCID: GC0XP002978
|
|
arylsulfatase F
| |
Aliases
for ARSF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Arylsulfatase F1 2 | | ASF2 3 | | EC 3.1.6.-3 | | EC 3.1.68 | | EC 3.1.6.28 |
Export aliases for ARSF gene to outside databasesPrevious GC identifers: GC0XP002264 GC0XP002158 GC0XP002514 GC0XP002579 GC0XP000927 |
Summaries
for ARSF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARSF:
This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of thesubfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting thatthey are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone andcartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiplealternatively spliced variants, encoding the same protein, have been identified.(provided by RefSeq, Jan 2011)
|
Genomic Views
for ARSF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ARSF
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARSF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARSF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.3 Ensembl cytogenetic band: Xp22.33 HGNC cytogenetic band: Xp22.3ARSF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP002978: view genomic region
(about GC identifiers)
Start:
|
2,959,512 bp from pter |
End:
|
3,030,767 bp from pter |
Size:
|
71,256 bases |
Orientation:
|
plus strand |
|
Proteins
for ARSF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARSF_HUMAN, P54793 (See
protein sequence)Recommended Name: Arylsulfatase F precursor Size: 590 amino acids; 65940 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Secreted (Potential)
Secondary accessions: Q8TCC5Explore the universe of human proteins at neXtProt for ARSF: NX_P54793
Post-translational modifications:
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotesand of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P54793
4/6 DME Specific Peptides for ARSF (P54793) (see all 6)
ARSF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001188467.1 NP_001188468.1 NP_004033.2
ENSEMBL proteins: ENSP00000370519 ENSP00000352319 ENSP00000445594 Reactome Protein details: P54793
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005788 | endoplasmic reticulum lumen |
TAS | -- |
ARSF for ontologies About GeneDecksing
ARSF Antibody Products:
Assay Products for ARSF: |
Protein
Domains /
Families
for ARSF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARSF for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P54793ProtoNet protein and cluster: P54793 1 Blocks protein family: IPB000917 Sulfatase
UniProtKB/Swiss-Prot: ARSF_HUMAN, P54793Similarity: Belongs to the sulfatase family |
Function
for ARSF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARSF_HUMAN, P54793Enzyme regulation: Not inhibited by DHEAS or warfarinBiophysicochemical properties: pH dependence: Optimum pH is 8; Genatlas biochemistry entry for ARSF:arylsulfatase F,X-linked,escaping inactivation,highly homologous to ARSC1,heat labile,not inhibited by warfarin
Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.6.22 EC 3.1.62
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARSF (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSF |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ARSF for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ARSF:
|
Pathways & Interactions
for ARSF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Sphingolipid metabolism | | | 2 | PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | | | 3 | Metabolism | | | 4 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for ARSF (see all 8)
ARSF for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARSF
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/13 Interacting proteins for ARSF (P547933 ENSP000003523194) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006644 | phospholipid metabolic process |
TAS | -- | | GO:0006665 | sphingolipid metabolic process |
TAS | -- | | GO:0006687 | glycosphingolipid metabolic process |
TAS | -- | | GO:0043687 | post-translational protein modification |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
ARSF for ontologies About GeneDecksing
|
Drugs & Compounds
for ARSF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARSF
1 HMDB Compound for ARSF About this table
Search CenterWatch for drugs/clinical trials and news about ARSF
|
Transcripts
for ARSF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARSF gene (3 alternative transcripts): NM_001201538.1 NM_001201539.1 NM_004042.4 Unigene Cluster for ARSF: Arylsulfatase F Hs.101674 [show with all ESTs]Unigene Representative Sequence: BC0223893 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381127(uc022brz.1 uc004cre.2) ENST00000359361(uc004crf.2)
ENST00000537104
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARSF
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARSF (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ARSF (NM_001201538) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARSF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSF |
Additional cDNA sequence: BC022389.1 X97868.1 3 DOTS entries: DT.40120125 DT.40120126 DT.100744166 18 AceView cDNA sequences: BQ228278 BC022389 CD557574 NM_004042 BV183280 BI758861 BX107362 AI796044 X97868 AI471853 AI651169 BG432126 AW612447 AI675063 H08174 AI245163 H08273 AW301236
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ARSF About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARSF
|
Expression
for ARSF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARSF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTTCTTTT
About this image
See ARSF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARSF
SOURCE GeneReport for Unigene cluster: Hs.101674
SABiosciences Custom PCR Arrays for ARSF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARSF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ARSF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARSF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSF |
Orthologs
for ARSF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for ARSF gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for ARSF (if available)
TreeFam Gene Tree for ARSF (if available) |
Paralogs
for ARSF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARSF gene
- ARSJ2 ARSI2 ARSG2 ARSA2 ARSH2 STS2 ARSB2 GALNS2
- ARSE2 ARSD2
5 SIMAP similar genes for ARSF using alignment to 1 protein entry: ARSF_HUMAN:ARSD ARSE ARSH STS IDS
ARSF for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ARSF
PGOHUM00000233745
|
Genomic Variants
for ARSF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARSF (2959512 - 3030767 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ARSF
4 CNVs: 8294 3260 8293 4142
Human Gene Mutation Database (HGMD): ARSF
Locus Specific Mutation Databases (LSDB): ARSF
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARSF |
|
Disorders
/ Diseases
for ARSF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARSF for disorders About GeneDecksing
OMIM gene information: 300003
OMIM disorders: --
4  diseases for ARSF: About MalaCardschondrodysplasia punctata chondrodysplasia tuberculosis mycobacterium tuberculosis
Export disorders for ARSF gene to outside databases
|
Publications
for ARSF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARSF gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ARSF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy. (PubMed id 7720070)1, 2, 3 Franco B.... Ballabio A. (1995)
- Identification by shotgun sequencing, genomic organization, and functional analysis of a fourth arylsulfatase gene (ARSF) from the Xp22.3 region. (PubMed id 9192838)1, 2, 9 Puca A.A.... Franco B. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding. (PubMed id 9685421)1 Cao W. and Garcia-Blanco M.A. (1998)
- The sulfatase gene family. (PubMed id 9229115)1 Parenti G....Ballabio A. (1997)
|
External Searches for ARSF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARSF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARSF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARSF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARSF | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARSF gene:
Search GeneIP for patents involving ARSF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARSF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARSF | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARSF | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARSF | | | OriGene Protein Over-expression Lysate for ARSF | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARSF | | OriGene 3'-UTR Clone for ARSF | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARSF | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARSF | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARSF | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSF |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARSF |
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