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Aliases for ARSF Gene

Aliases for ARSF Gene

  • Arylsulfatase F 2 3
  • ASF 3 4
  • EC 3.1.6.2 63
  • EC 3.1.6.- 4
  • EC 3.1.6 63

External Ids for ARSF Gene

Previous GeneCards Identifiers for ARSF Gene

  • GC0XP002264
  • GC0XP002158
  • GC0XP002514
  • GC0XP002579
  • GC0XP002978
  • GC0XP000927

Summaries for ARSF Gene

Entrez Gene Summary for ARSF Gene

  • This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of the subfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting that they are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone and cartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jan 2011]

GeneCards Summary for ARSF Gene

ARSF (Arylsulfatase F) is a Protein Coding gene. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include arylsulfatase activity. An important paralog of this gene is ARSJ.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARSF Gene

Genomics for ARSF Gene

Genomic Location for ARSF Gene

Start:
3,040,234 bp from pter
End:
3,112,729 bp from pter
Size:
72,496 bases
Orientation:
Plus strand

Genomic View for ARSF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARSF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARSF Gene

No data available for Regulatory Elements for ARSF Gene

Proteins for ARSF Gene

  • Protein details for ARSF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54793-ARSF_HUMAN
    Recommended name:
    Arylsulfatase F
    Protein Accession:
    P54793
    Secondary Accessions:
    • Q8TCC5

    Protein attributes for ARSF Gene

    Size:
    590 amino acids
    Molecular mass:
    65940 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for ARSF Gene

Proteomics data for ARSF Gene at MOPED

Selected DME Specific Peptides for ARSF Gene

Post-translational modifications for ARSF Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn50, Asn117, and Asn336
  • Modification sites at PhosphoSitePlus

Other Protein References for ARSF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ARSF Gene

Gene Families for ARSF Gene

HGNC:
  • ARS :Arylsulfatase family

Protein Domains for ARSF Gene

Suggested Antigen Peptide Sequences for ARSF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54793

UniProtKB/Swiss-Prot:

ARSF_HUMAN :
  • P54793
Family:
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with ARSF: view

Function for ARSF Gene

Molecular function for ARSF Gene

GENATLAS Biochemistry: arylsulfatase F,X-linked,escaping inactivation,highly homologous to ARSC1,heat labile,not inhibited by warfarin
UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 8.;
UniProtKB/Swiss-Prot EnzymeRegulation: Not inhibited by DHEAS or warfarin

Enzyme Numbers (IUBMB) for ARSF Gene

Gene Ontology (GO) - Molecular Function for ARSF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004065 arylsulfatase activity TAS 9192838
GO:0008484 sulfuric ester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARSF: view

Phenotypes for ARSF Gene

genes like me logo Genes that share phenotypes with ARSF: view

miRNA for ARSF Gene

miRTarBase miRNAs that target ARSF

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ARSF Gene

Localization for ARSF Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARSF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARSF Gene COMPARTMENTS Subcellular localization image for ARSF gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 3
lysosome 3
plasma membrane 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARSF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARSF: view

Pathways for ARSF Gene

genes like me logo Genes that share pathways with ARSF: view

Gene Ontology (GO) - Biological Process for ARSF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0008152 metabolic process --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with ARSF: view

Compounds for ARSF Gene

(1) HMDB Compounds for ARSF Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with ARSF: view

Transcripts for ARSF Gene

mRNA/cDNA for ARSF Gene

(18) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(6) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARSF Gene

Arylsulfatase F:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARSF

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARSF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -

Relevant External Links for ARSF Gene

GeneLoc Exon Structure for
ARSF
ECgene alternative splicing isoforms for
ARSF

Expression for ARSF Gene

mRNA expression in normal human tissues for ARSF Gene

mRNA differential expression in normal tissues according to GTEx for ARSF Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (6.9), Brain - Putamen (basal ganglia) (4.8), Skin - Sun Exposed (Lower leg) (4.7), and Brain - Caudate (basal ganglia) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARSF Gene

SOURCE GeneReport for Unigene cluster for ARSF Gene Hs.101674

genes like me logo Genes that share expressions with ARSF: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARSF Gene

Orthologs for ARSF Gene

This gene was present in the common ancestor of animals.

Orthologs for ARSF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARSF 35
  • 99.34 (n)
  • 98.25 (a)
ARSF 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARSF 35
  • 78.14 (n)
  • 75.17 (a)
ARSF 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARSF 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARSF 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii arsh 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sul-2 35
  • 47.26 (n)
  • 41.01 (a)
sul-2 36
  • 33 (a)
OneToMany
D1014.1 37
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
Species with no ortholog for ARSF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARSF Gene

ENSEMBL:
Gene Tree for ARSF (if available)
TreeFam:
Gene Tree for ARSF (if available)

Paralogs for ARSF Gene

Paralogs for ARSF Gene

Selected SIMAP similar genes for ARSF Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ARSF Gene

genes like me logo Genes that share paralogs with ARSF: view

Variants for ARSF Gene

Sequence variations from dbSNP and Humsavar for ARSF Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs719547 -- 3,101,743(-) ATTTA(C/G)TCCAC intron-variant
rs936050 -- 3,094,364(+) GCCCC(A/G)TTAGA intron-variant
rs960372 -- 3,071,249(-) tgcag(C/T)tgcaa intron-variant
rs1010041 -- 3,101,424(-) ACATA(A/C)ATGGC intron-variant
rs1052638 - 3,112,362(+) CCCTC(C/T)ATGAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ARSF Gene

Variant ID Type Subtype PubMed ID
dgv2432e1 CNV Complex 17122850
esv34985 CNV Gain 17911159
essv3621 CNV CNV 17122850
dgv13n29 CNV Gain 16826518
esv2752320 CNV Gain 17911159

Relevant External Links for ARSF Gene

HapMap Linkage Disequilibrium report
ARSF
Human Gene Mutation Database (HGMD)
ARSF
Locus Specific Mutation Databases (LSDB)
ARSF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARSF Gene

Disorders for ARSF Gene

No disorders were found for ARSF Gene.

No data available for UniProtKB/Swiss-Prot for ARSF Gene

Publications for ARSF Gene

  1. A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy. (PMID: 7720070) Franco B. … Ballabio A. (Cell 1995) 2 3 4
  2. Identification by shotgun sequencing, genomic organization, and functional analysis of a fourth arylsulfatase gene (ARSF) from the Xp22.3 region. (PMID: 9192838) Puca A.A. … Franco B. (Genomics 1997) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ARSF Gene

Sources for ARSF Gene

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