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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARSD Gene

protein-coding   GIFtS: 57
GCID: GC0XM002818

Arylsulfatase D

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arylsulfatase D1 2
ASD2 3
EC 3.1.6.-3
EC 3.1.6.28

External Ids:    HGNC: 7171   Entrez Gene: 4142   Ensembl: ENSG000000067567   OMIM: 3000025   UniProtKB: P516893   

Export aliases for ARSD gene to outside databases

Previous GC identifers: GC0XM002129 GC0XM001993 GC0XM002353 GC0XM002420 GC0XM000764


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARSD Gene:
The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct
composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to
the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related
pseudogene has been identified in the pseudoautosomal region of chromosome Y. (provided by RefSeq, Jul 2011)

GeneCards Summary for ARSD Gene: 
ARSD (arylsulfatase D) is a protein-coding gene. Diseases associated with ARSD include chondrodysplasia punctata, tibia metacarpal type, and craniometaphyseal dysplasia, and among its related super-pathways are Sphingolipid metabolism and The activation of arylsulfatases. GO annotations related to this gene include arylsulfatase activity and metal ion binding. An important paralog of this gene is ARSF.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARSD
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARSD promoter sequence
   Search SABiosciences Chromatin IP Primers for ARSD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARSD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.3

ARSD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARSD gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM002818:  view genomic region     (about GC identifiers)

Start:
2,822,011 bp from pter      End:
2,847,392 bp from pter
Size:
25,382 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARSD_HUMAN, P51689 (See protein sequence)
Recommended Name: Arylsulfatase D precursor  
Size: 593 amino acids; 64860 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Lysosome (Potential)
Sequence caution: Sequence=CAA58555.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q9UHJ8
Alternative splicing: 3 isoforms:  P51689-1   P51689-2   P51689-3   

Explore the universe of human proteins at neXtProt for ARSD: NX_P51689

Explore proteomics data for ARSD at MOPED 

Post-translational modifications:

  • UniProtKB: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in
    prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51689

  • 3 DME Specific Peptides for ARSD (P51689)
     NGIYKGG  HEFLFHYC  WEGGIRVPG 

    ARSD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARSD Protein Expression
    REFSEQ proteins: NP_001660.2  
    ENSEMBL proteins: 
     ENSP00000370546   ENSP00000409180   ENSP00000453789  
    Reactome Protein details: P51689
    Human Recombinant Protein Products for ARSD: 
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    Novus Biologicals ARSD Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARSD 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IEA--
    GO:0005788endoplasmic reticulum lumen TAS--

    ARSD for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARS: Arylsulfatase family

    4 InterPro protein domains:
     IPR000917 Sulfatase
     IPR017849 Alkaline_Pase-like_a/b/a
     IPR024607 Sulfatase_CS
     IPR017850 Alkaline_phosphatase_core

    Graphical View of Domain Structure for InterPro Entry P51689

    ProtoNet protein and cluster: P51689

    1 Blocks protein domain: IPB000917 Sulfatase

    UniProtKB/Swiss-Prot: ARSD_HUMAN, P51689
    Similarity: Belongs to the sulfatase family


    ARSD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for ARSD:
    arylsulfatase D,X-linked,escaping inactivation,highly homologous to ARSC1 with two alternatively spliced isoforms

         Enzyme Numbers (IUBMB): EC 3.1.6.-1 EC 3.1.6.22

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004065arylsulfatase activity TAS7720070
    GO:0008484sulfuric ester hydrolase activity ----
    GO:0046872metal ion binding IEA--
         
    ARSD for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARSD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARSD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARSD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARSD 

    miRNA
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARSD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.63
    Glycosphingolipid metabolism0.55
    2PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation0.46
    The activation of arylsulfatases0.46
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    5Estrogen metabolism
    Estrogen metabolism0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ARSD
        Estrogen metabolism

    5/8        Reactome Pathways for ARSD (see all 8)
        Sphingolipid metabolism
    Glycosphingolipid metabolism
    Metabolism
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    Metabolism of proteins



    ARSD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARSD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ARSD (ENSP000003705464) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSAENSP000002161244STRING: ENSP00000216124
    ARSBENSP000002649144STRING: ENSP00000264914
    ARSEENSP000003705264STRING: ENSP00000370526
    ARSFENSP000003523194STRING: ENSP00000352319
    ARSHENSP000003705224STRING: ENSP00000370522
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006665sphingolipid metabolic process TAS--
    GO:0006687glycosphingolipid metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    ARSD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARSD

    10/13 HMDB Compounds for ARSD (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-3--
    CalciumCa (see all 2)7440-70-2--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone sulfateConestoral (see all 12)481-97-0--
    Galactosylceramide (d18:1/16:0)Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/18:0)Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/18:1(9Z))Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/20:0)Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/22:0)Galactocerebroside (see all 15)----
    Galactosylceramide (d18:1/24:1(15Z))Galactocerebroside (see all 15)----

    Search CenterWatch for drugs/clinical trials and news about ARSD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARSD gene (2 alternative transcripts): 
    NM_001669.3  NM_009589.2  

    Unigene Cluster for ARSD:

    Arylsulfatase D
    Hs.528631  [show with all ESTs]
    Unigene Representative Sequence: NM_001669
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381154(uc004cqy.3) ENST00000458014 ENST00000495294 ENST00000217890
    ENST00000481340 ENST00000494870(uc004crb.4) ENST00000559324
    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARSD
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARSD
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSD

    Additional mRNA sequence: 

    AF160499.1 AK021472.1 AK055239.1 AK314479.1 BC020229.1 X83572.1 

    7 DOTS entries:

    DT.216075  DT.110587  DT.100019920  DT.95154198  DT.92444601  DT.100846272  DT.121308743 

    24/335 AceView cDNA sequences (see all 335):

    AI683233 BX091647 R64678 AI738924 BQ269749 AU105235 AA693875 BM678192 
    N51378 AI435190 NM_000047 BM855048 AI679510 AW779826 AU099657 AI801393 
    CA436470 AI128344 BF197551 AI474656 BQ001174 N52322 CK821513 AI347771 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ARSD    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                -                       -     -                             -               
    SP2:                                -                                                                           
    SP3:                                                                                                            
    SP4:              -     -     -     -     -     -     -     -     -     -     -     -                           
    SP5:                                                  -                                                         


    ECgene alternative splicing isoforms for ARSD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARSD expression in normal human tissues (normalized intensities)      ARSD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTGTTTCT
    ARSD Expression
    About this image


    ARSD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See ARSD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARSD

    SOURCE GeneReport for Unigene cluster: Hs.528631

    UniProtKB/Swiss-Prot: ARSD_HUMAN, P51689
    Tissue specificity: Expressed in the pancreas, kidney, liver, lung, placenta, brain and heart

        SABiosciences Custom PCR Arrays for ARSD
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARSD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARSD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARSD gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ARSD1 arylsulfatase D 79.53(n)
    81.48(a)
      491718  XM_548838.4  XP_548838.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL886196.22   -- 73.75(n)    AL886196.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003329971 steryl-sulfatase-like 60.78(n)
    54.83(a)
      100332997  XM_003199265.1  XP_003199313.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sul-26
    Protein SUL-2
    30(a)
    1 → many
    V(8157746-8159874)


    ENSEMBL Gene Tree for ARSD (if available)
    TreeFam Gene Tree for ARSD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARSD gene
    ARSF2  ARSI2  ARSJ2  ARSG2  ARSA2  STS2  ARSH2  ARSB2  
    GALNS2  ARSE2  
    4 SIMAP similar genes for ARSD using alignment to 3 protein entries:     ARSD_HUMAN (see all proteins):
    ARSH    ARSE    ARSF    STS

    ARSD for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARSD
    PGOHUM00000233955


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/827 SNPs in ARSD are shown (see all 827)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs780347361,2
    C,Funtested12809151(+) AAACAG/TCTTCC 2 D A mis12Minor allele frequency- T:0.50CSA 4
    rs1836672561,2
    --2794870(+) CTGACA/TTCCTT 1 -- ds50010--------
    rs1488543441,2
    C--2794879(+) TTCAGC/TTAACT 1 -- ds50010--------
    rs1479883461,2
    --2795071(+) AAGGCA/GTTCTT 1 -- ds50010--------
    rs1895495631,2
    --2795086(+) CCAGTC/TGCCCT 1 -- ds50010--------
    rs173351211,2
    C,F--2795157(+) CAGAAC/TGGGGG 1 -- ds50019Minor allele frequency- N:0.01NA EA WA CSA 223
    rs1472289851,2
    --2795193(+) CATGAA/GTAGTG 1 -- ds50010--------
    rs41412101,2
    C,A,H--2795267(+) GATTGC/AGGATG 1 -- ds50012Minor allele frequency- A:0.00NA 6
    rs41412111,2
    C,F,A,H--2795268(+) ATTGAG/TGATGG 1 -- ds50017Minor allele frequency- T:0.02NS EA NA 382
    rs2016922301,2
    C--2795281(+) AATAA-/AAAC  
            
    AAACA
    1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ARSD (2822011 - 2847392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARSD:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv32931CNV Loss17666407
    nsv526612CNV Loss19592680
    esv34985CNV Gain17911159
    essv3621CNV CNV17122850
    essv21575CNV CNV17122850
    dgv2432e1CNV Complex17122850


    Locus Specific Mutation Databases (LSDB): ARSD
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300002    OMIM disorders: --

    13 diseases for ARSD:    About MalaCards
    chondrodysplasia punctata, tibia metacarpal type    craniometaphyseal dysplasia    gastric dilatation    spondylocostal dysostosis
    dysostosis    metachromatic leukodystrophy    spinal stenosis    leukodystrophy
    chondrodysplasia    mucopolysaccharidosis    tuberculosis    chronic lymphocytic leukemia
    leukemia

    4 diseases from the University of Copenhagen DISEASES database for ARSD:
    Metachromatic leukodystrophy     Mucosulfatidosis     Mucopolysaccharidosis VI     Gastric dilatation

    ARSD for disorders           About GeneDecksing


    Export disorders for ARSD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARSD gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ARSD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy. (PubMed id 7720070)1, 2, 3 Franco B.... Ballabio A. (1995)
    2. Arylsulfatase D gene in Xp22.3 encodes two protein isoforms. (PubMed id 11177574)1, 2, 9 Urbitsch P.... Vogt P.H. (2000)
    3. Identification by shotgun sequencing, genomic organization, and functional analysis of a fourth arylsulfatase gene (ARSF) from the Xp22.3 region. (PubMed id 9192838)1, 9 Puca A.A.... Franco B. (1997)
    4. Characterization of a cluster of sulfatase genes on Xp22.3 suggests gene duplications in an ancestral pseudoautosomal region. (PubMed id 8845834)1, 9 Meroni G....Ballabio A. (1996)
    5. Longterm follow-up in chondrodysplasia punctata, tibia-metacarpal type, demonstrating natural history. (PubMed id 14699613)1, 9 Savarirayan R....Sheffield L.J. (2004)
    6. Expression profiling of human sulfotransferase and sulfatase gene superfamilies in epithelial tissues and cultured cells. (PubMed id 11027669)1, 9 Dooley T.P....Wilborn T.W. (2000)
    7. Comparative mapping of Xp22 genes in hominoids--evolutionary linear instability of their Y homologues. (PubMed id 9246409)1, 9 Glaser B....Schempp W. (1997)
    8. Gene expression profiling identifies ARSD as a new mar ker of disease progression and the sphingolipid metabolism as a potential novel metabolism in chronic lymphocytic leukemia. (PubMed id 22820137)1 Trojani A....Morra E. (2011-2012)
    9. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 414 HGNC: 717 AceView: ARSEandARSD Ensembl:ENSG00000006756 euGenes: HUgn414
    ECgene: ARSD H-InvDB: ARSD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARSD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARSD gene:
    Search GeneIP for patents involving ARSD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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