Aliases for ARSB Gene
External Ids for ARSB Gene
Previous GeneCards Identifiers for ARSB Gene
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARSB Gene
ARSB (Arylsulfatase B) is a Protein Coding gene. Diseases associated with ARSB include mucopolysaccharidosis type vi and mucopolysaccharidosis type 6, slowly progressing. Among its related pathways are Disease and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include arylsulfatase activity and N-acetylgalactosamine-4-sulfatase activity. An important paralog of this gene is ARSJ.
UniProtKB/Swiss-Prot for ARSB Gene
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).