Aliases for ARSB Gene
External Ids for ARSB Gene
Previous GeneCards Identifiers for ARSB Gene
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targeted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2016]
GeneCards Summary for ARSB Gene
ARSB (Arylsulfatase B) is a Protein Coding gene. Diseases associated with ARSB include Mucopolysaccharidosis Type Vi and Mucopolysaccharidosis Type 6, Slowly Progressing. Among its related pathways are Glycosaminoglycan metabolism and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include sulfuric ester hydrolase activity and N-acetylgalactosamine-4-sulfatase activity. An important paralog of this gene is ARSJ.
UniProtKB/Swiss-Prot for ARSB Gene
Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).