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Aliases for ARRDC5 Gene

Aliases for ARRDC5 Gene

  • Arrestin Domain Containing 5 2 3 5

External Ids for ARRDC5 Gene

Previous GeneCards Identifiers for ARRDC5 Gene

  • GC19M004843
  • GC19U900462
  • GC19M004844
  • GC19M004652

Summaries for ARRDC5 Gene

GeneCards Summary for ARRDC5 Gene

ARRDC5 (Arrestin Domain Containing 5) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC5 Gene

Genomics for ARRDC5 Gene

Regulatory Elements for ARRDC5 Gene

Enhancers for ARRDC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARRDC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARRDC5 Gene

4,890,437 bp from pter
4,916,820 bp from pter
26,384 bases
Minus strand

Genomic View for ARRDC5 Gene

Genes around ARRDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC5 Gene

Proteins for ARRDC5 Gene

  • Protein details for ARRDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arrestin domain-containing protein 5
    Protein Accession:

    Protein attributes for ARRDC5 Gene

    342 amino acids
    Molecular mass:
    38383 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAW69191.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ARRDC5 Gene

Post-translational modifications for ARRDC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARRDC5 Gene

Domains & Families for ARRDC5 Gene

Gene Families for ARRDC5 Gene

Protein Domains for ARRDC5 Gene

Suggested Antigen Peptide Sequences for ARRDC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the arrestin family.
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC5: view

Function for ARRDC5 Gene

Phenotypes for ARRDC5 Gene

GenomeRNAi human phenotypes for ARRDC5:
genes like me logo Genes that share phenotypes with ARRDC5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARRDC5 Gene

Localization for ARRDC5 Gene

Subcellular locations from

Jensen Localization Image for ARRDC5 Gene COMPARTMENTS Subcellular localization image for ARRDC5 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARRDC5 Gene

Pathways & Interactions for ARRDC5 Gene

SuperPathways for ARRDC5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC5 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARRDC5 Gene

Drugs & Compounds for ARRDC5 Gene

No Compound Related Data Available

Transcripts for ARRDC5 Gene

mRNA/cDNA for ARRDC5 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARRDC5 Gene

Arrestin domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC5 Gene

No ASD Table

Relevant External Links for ARRDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARRDC5 Gene

mRNA expression in normal human tissues for ARRDC5 Gene

mRNA differential expression in normal tissues according to GTEx for ARRDC5 Gene

This gene is overexpressed in Testis (x28.7) and Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for ARRDC5 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARRDC5 Gene

Protein tissue co-expression partners for ARRDC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARRDC5 Gene:


SOURCE GeneReport for Unigene cluster for ARRDC5 Gene:

genes like me logo Genes that share expression patterns with ARRDC5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARRDC5 Gene

Orthologs for ARRDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARRDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARRDC5 34
  • 84.56 (n)
  • 81.9 (a)
  • 80 (a)
(Canis familiaris)
Mammalia ARRDC5 34
  • 84.56 (n)
  • 81.82 (a)
  • 78 (a)
(Mus musculus)
Mammalia Arrdc5 34
  • 74.68 (n)
  • 72.44 (a)
Arrdc5 16
Arrdc5 35
  • 70 (a)
(Pan troglodytes)
Mammalia ARRDC5 34
  • 98.93 (n)
  • 97.95 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Arrdc5 34
  • 75 (n)
  • 74.68 (a)
(Gallus gallus)
Aves LOC101752017 34
  • 58.04 (n)
  • 49.65 (a)
Species where no ortholog for ARRDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARRDC5 Gene

Gene Tree for ARRDC5 (if available)
Gene Tree for ARRDC5 (if available)

Paralogs for ARRDC5 Gene

No data available for Paralogs for ARRDC5 Gene

Variants for ARRDC5 Gene

Sequence variations from dbSNP and Humsavar for ARRDC5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs28374313 -- 4,895,444(+) AAAAA(A/G)AAAGA intron-variant
rs28526006 -- 4,900,395(+) TAACA(C/G)GTGTG intron-variant
rs11451900 -- 4,895,117(+) TTTTT(-/T)AATAG intron-variant
rs28668455 -- 4,890,488(+) CCTGG(G/T)CTCAA utr-variant-3-prime
rs33946883 -- 4,891,968(+) AAAAA(-/A/AA)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARRDC5 Gene

Variant ID Type Subtype PubMed ID
esv25954 CNV gain 19812545
esv3893158 CNV loss 25118596
nsv1065556 CNV loss 25217958
nsv1141946 OTHER inversion 24896259
nsv470117 CNV loss 18288195

Variation tolerance for ARRDC5 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARRDC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC5 Gene

Disorders for ARRDC5 Gene

Relevant External Links for ARRDC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARRDC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC5 Gene

Publications for ARRDC5 Gene

  1. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. (PMID: 12886014) Cal S. … Lopez-Otin C. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 65
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 65

Products for ARRDC5 Gene

Sources for ARRDC5 Gene

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