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ARRDC5 Gene

protein-coding   GIFtS: 33
GCID: GC19M004890

Arrestin Domain Containing 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arrestin Domain Containing 51 2
Arrestin Domain-Containing Protein 52

External Ids:    HGNC: 314071   Entrez Gene: 6454322   Ensembl: ENSG000002057847   UniProtKB: A6NEK13   

Export aliases for ARRDC5 gene to outside databases

Previous GC identifers: GC19M004843 GC19U900462 GC19M004844 GC19M004652


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARRDC5 Gene:
ARRDC5 (arrestin domain containing 5) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARRDC5 gene promoter:
         Max1   Egr-3   AML1a   MZF-1   PPAR-gamma1   CBF-A   STAT3   PPAR-gamma2   CBF(2)   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ARRDC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARRDC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ARRDC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARRDC5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004890:  view genomic region     (about GC identifiers)

Start:
4,890,449 bp from pter      End:
4,902,879 bp from pter
Size:
12,431 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARRD5_HUMAN, A6NEK1 (See protein sequence)
Recommended Name: Arrestin domain-containing protein 5  
Size: 342 amino acids; 38383 Da
Caution: It is uncertain whether Met-1 or Met-15 is the initiator
Sequence caution: Sequence=EAW69191.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for ARRDC5: NX_A6NEK1

Explore proteomics data for ARRDC5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARRDC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073992.1  
    ENSEMBL proteins: 
     ENSP00000371200  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR011022 Arrestin_C-like
     IPR011021 Arrestin-like_N

    Graphical View of Domain Structure for InterPro Entry A6NEK1

    ProtoNet protein and cluster: A6NEK1

    UniProtKB/Swiss-Prot: ARRD5_HUMAN, A6NEK1
    Similarity: Belongs to the arrestin family


    Find genes that share domains with ARRDC5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARRDC5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARRDC5
    Interactions:

        Search GeneGlobe Interaction Network for ARRDC5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ARRDC5 (ENSP000003712004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DUS2ENSP000003517694STRING: ENSP00000351769
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARRDC5 (ARRD5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARRDC5 gene: 
    NM_001080523.1  

    Unigene Cluster for ARRDC5:

    Arrestin domain containing 5
    Hs.574574  [show with all ESTs]
    Unigene Representative Sequence: NM_001080523
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381781(uc002mbm.3)
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    1 DOTS entry:

    DT.75133665 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARRDC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGAGGAT
    ARRDC5 Expression
    About this image

    ARRDC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARRDC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.574574
        Custom PCR Arrays for ARRDC5
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ARRDC5 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arrdc51 , 5 arrestin domain containing 51, 5 74.68(n)1
    72.44(a)1
      17 (29.26 cM)5
    769201  NM_029799.11  NP_084075.11 
     562941135 
    chicken
    (Gallus gallus)
    Aves LOC1017520171 arrestin domain-containing protein 5-like 58.04(n)
    49.65(a)
      101752017  XM_004937609.1  XP_004937666.1 


    ENSEMBL Gene Tree for ARRDC5 (if available)
    TreeFam Gene Tree for ARRDC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARRDC5 (see all 414)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729861041,2
    C--4890102(+) GCACAC/TCATCA 1 -- ds50010--------
    rs1458370321,2
    --4890109(+) ATCACA/GCCTGG 1 -- ds50010--------
    rs1869604871,2
    --4890129(+) CTTTTC/TTTTTT 1 -- ds50010--------
    rs26026941,2
    C,F--4890329(-) TAACAC/TGGTGA 1 -- ds50013Minor allele frequency- T:0.50NA CSA 6
    rs1470647341,2
    --4890365(+) TGATCC/TGCCTG 1 -- ds50010--------
    rs27791751,2
    C,F,A,H--4890433(-) aaagaG/Aaaaaa 1 -- ds50015Minor allele frequency- A:0.28WA NA 244
    rs341641891,2
    C--4890436(+) TTTTT-/TGTAGA 1 -- ds50012Minor allele frequency- T:0.00NA CSA 4
    rs1160286771,2
    C--4890579(+) TGGTAC/TTGTTG 1 -- ut310--------
    rs1918099661,2
    --4890674(+) CCACGA/CCAATA 1 -- ut310--------
    rs1423534201,2
    C--4890677(+) CGCCAA/GTAAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARRDC5 (4890449 - 4902879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARRDC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910863CNV Loss21882294
    dgv3682n71CNV Loss21882294
    nsv910860CNV Loss21882294
    nsv910862CNV Loss21882294
    nsv470117CNV Loss18288195
    esv25954CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARRDC5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ARRDC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. (PubMed id 12886014)1, 3 Cal S.... Lopez-Otin C. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 645432 HGNC: 31407 Ensembl:ENSG00000205784 euGenes: HUgn645432 ECgene: ARRDC5
    H-InvDB: ARRDC5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARRDC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARRDC5 gene:
    Search GeneIP for patents involving ARRDC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     antibodies-online peptides for ARRDC5
     antibodies-online proteins for ARRDC5 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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