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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARRDC5 Gene

protein-coding   GIFtS: 31
GCID: GC19M004890

Arrestin Domain Containing 5

  Search for ARRDC5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arrestin Domain Containing 51 2
Arrestin Domain-Containing Protein 52

External Ids:    HGNC: 314071   Entrez Gene: 6454322   Ensembl: ENSG000002057847   UniProtKB: A6NEK13   

Export aliases for ARRDC5 gene to outside databases

Previous GC identifers: GC19M004843 GC19U900462 GC19M004844 GC19M004652


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARRDC5 Gene: 
ARRDC5 (arrestin domain containing 5) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARRDC5 gene promoter:
         Max1   Egr-3   AML1a   MZF-1   PPAR-gamma1   CBF-A   STAT3   PPAR-gamma2   CBF(2)   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ARRDC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARRDC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ARRDC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARRDC5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004890:  view genomic region     (about GC identifiers)

Start:
4,890,449 bp from pter      End:
4,902,879 bp from pter
Size:
12,431 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARRD5_HUMAN, A6NEK1 (See protein sequence)
Recommended Name: Arrestin domain-containing protein 5  
Size: 342 amino acids; 38383 Da
Caution: It is uncertain whether Met-1 or Met-15 is the initiator
Sequence caution: Sequence=EAW69191.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for ARRDC5: NX_A6NEK1

Explore proteomics data for ARRDC5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NEK1

  • ARRDC5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARRDC5 Protein Expression
    REFSEQ proteins: NP_001073992.1  
    ENSEMBL proteins: 
     ENSP00000371200  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR011022 Arrestin_C-like
     IPR011021 Arrestin-like_N

    Graphical View of Domain Structure for InterPro Entry A6NEK1

    ProtoNet protein and cluster: A6NEK1

    UniProtKB/Swiss-Prot: ARRD5_HUMAN, A6NEK1
    Similarity: Belongs to the arrestin family


    ARRDC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARRDC5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARRDC5 (ARRD5)

    Search CenterWatch for drugs/clinical trials and news about ARRDC5 / ARRD5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ARRDC5 gene: 
    NM_001080523.1  

    Unigene Cluster for ARRDC5:

    Arrestin domain containing 5
    Hs.574574  [show with all ESTs]
    Unigene Representative Sequence: NM_001080523
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381781(uc002mbm.3)
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    1 DOTS entry:

    DT.75133665 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARRDC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGAGGAT
    ARRDC5 Expression
    About this image


    See ARRDC5 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.574574
        SABiosciences Custom PCR Arrays for ARRDC5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ARRDC5 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arrdc51 , 5 arrestin domain containing 51, 5 74.68(n)1
    72.44(a)1
      17 (29.26 cM)5
    769201  NM_029799.11  NP_084075.11 
     562941135 


    ENSEMBL Gene Tree for ARRDC5 (if available)
    TreeFam Gene Tree for ARRDC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/414 SNPs in ARRDC5 are shown (see all 414)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs729861041,2
    C--4890102(+) GCACAC/TCATCA 1 -- ds50010--------
    rs1458370321,2
    --4890109(+) ATCACA/GCCTGG 1 -- ds50010--------
    rs1869604871,2
    --4890129(+) CTTTTC/TTTTTT 1 -- ds50010--------
    rs26026941,2
    C,F--4890329(-) TAACAC/TGGTGA 1 -- ds50013Minor allele frequency- T:0.50NA CSA 6
    rs1470647341,2
    --4890365(+) TGATCC/TGCCTG 1 -- ds50010--------
    rs27791751,2
    C,F,A,H--4890433(-) aaagaG/Aaaaaa 1 -- ds50015Minor allele frequency- A:0.28WA NA 244
    rs341641891,2
    C--4890436(+) TTTTT-/TGTAGA 1 -- ds50012Minor allele frequency- T:0.00NA CSA 4
    rs1160286771,2
    C--4890579(+) TGGTAC/TTGTTG 1 -- ut310--------
    rs1918099661,2
    --4890674(+) CCACGA/CCAATA 1 -- ut310--------
    rs1423534201,2
    C--4890677(+) CGCCAA/GTAAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARRDC5 (4890449 - 4902879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARRDC5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv910863CNV Loss21882294
    dgv3682n71CNV Loss21882294
    nsv910860CNV Loss21882294
    nsv910862CNV Loss21882294
    nsv470117CNV Loss18288195
    esv25954CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARRDC5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARRDC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. (PubMed id 12886014)1, 3 Cal S.... Lopez-Otin C. (2003)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 645432 HGNC: 31407 Ensembl:ENSG00000205784 euGenes: HUgn645432 ECgene: ARRDC5
    H-InvDB: ARRDC5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARRDC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARRDC5 gene:
    Search GeneIP for patents involving ARRDC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    transforming growth factor, beta 1
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