ARRDC4 Gene
protein-coding GIFtS: 44
GCID: GC15P098503
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arrestin domain containing 4
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Aliases for ARRDC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Arrestin Domain Containing 41 2 | | FLJ360451 | | Arrestin Domain-Containing Protein 42 |
Export aliases for ARRDC4 gene to outside databasesPrevious GC identifers: GC00U913742 GC15P096233 GC15P096304 GC15P074633 |
Summaries for ARRDC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for ARRDC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010274.17
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARRDC4 gene promoter: POU2F2 (Oct-2.1) E2F-4 E2F-3a Oct-B1 E2F-5 E2F-2 POU2F2 POU2F2C E2F E2F-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ARRDC4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARRDC4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q26.3 Ensembl cytogenetic band: 15q26.2 HGNC cytogenetic band: 15q26.2ARRDC4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P098503: view genomic region
(about GC identifiers)
Start:
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98,462,784 bp from pter |
End:
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98,517,068 bp from pter |
Size:
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54,285 bases |
Orientation:
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plus strand |
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Proteins for ARRDC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ARRD4_HUMAN, Q8NCT1 (See
protein sequence)Recommended Name: Arrestin domain-containing protein 4 Size: 418 amino acids; 45479 Da
Secondary accessions: Q6NSI9Explore the universe of human proteins at neXtProt for ARRDC4: NX_Q8NCT1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCT1 ARRDC4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_899232.2 ENSEMBL proteins: ENSP00000268042 ENSP00000443774 Human Recombinant Protein Products:
ARRDC4 Antibody Products: Assay Products for ARRDC4: |
Protein
Domains / Families for ARRDC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARRDC4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NCT1ProtoNet protein and cluster: Q8NCT1 UniProtKB/Swiss-Prot: ARRD4_HUMAN, Q8NCT1Similarity: Belongs to the arrestin family |
Function for ARRDC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARRDC4 (NM_183376) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARRDC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC4 |
2 GenomeRNAi human phenotypes for ARRDC4:
|
Pathways & Interactions for ARRDC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARRDC4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
-- | -- |
ARRDC4 for ontologies About GeneDecksing
|
Drugs & Compounds for ARRDC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ARRDC4 Search CenterWatch for drugs/clinical trials and news about ARRDC4 / ARRD4 
|
Transcripts for ARRDC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ARRDC4 gene: NM_183376.2 Unigene Cluster for ARRDC4: Arrestin domain containing 4 Hs.6093 [show with all ESTs]Unigene Representative Sequence: NM_1833762 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000268042(uc002bui.4 uc010bom.3) ENST00000538249
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARRDC4 (NM_183376) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARRDC4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC4  |
Additional cDNA sequence: AK026436.1 AK093364.1 AK290221.1 AK296448.1 AK316280.1 BC028704.2 BC038453.1 BC070100.1 4 DOTS entries: DT.453161 DT.91790153 DT.100657968 DT.75121542 24/125 AceView cDNA sequences (see all 125): AA149653 Z45082 BX284073 BX501397 BU630296 AA345595 BM450159 CA424243 AW072445 BI917361 AI753503 BQ003246 BG698137 F08889 BC028704 CA448584 BM128224 BI770249 CB850502 BV179995 T26993 AI804017 AI332879 NM_183376 GeneLoc Exon Structure
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Expression for ARRDC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARRDC4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTTTGGTGCA
About this image See ARRDC4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARRDC4
SOURCE GeneReport for Unigene cluster: Hs.6093 SABiosciences Custom PCR Arrays for ARRDC4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARRDC4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARRDC4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARRDC4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARRDC4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC4 |
Orthologs for ARRDC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARRDC4 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for ARRDC4 (if available) TreeFam Gene Tree for ARRDC4 (if available)  |
Paralogs for ARRDC4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ARRDC4 gene
- TXNIP2 ARRDC32 ARRDC12 ARRDC22
3 SIMAP similar genes for ARRDC4 using alignment to 2 protein entries: ARRD4_HUMAN (see all proteins):ARRDC3 TXNIP ARRDC2
ARRDC4 for paralogs About GeneDecksing
|
Genomic Variants for ARRDC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 15 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for ARRDC4 (98462784 - 98517068 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ARRDC4: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARRDC4 |
|
Disorders
/ Diseases for ARRDC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARRDC4 for disorders About GeneDecksing
3 diseases for ARRDC4: About MalaCardscongenital diaphragmatic hernia lactic acidosis hernia 1 disease from the University of Copenhagen DISEASES database for ARRDC4:Congenital diaphragmatic hernia Export disorders for ARRDC4 gene to outside databases
|
Publications for ARRDC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARRDC4 gene integrated from 9 sources: (articles sorted by number of sources associating them with ARRDC4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- An anomalous haplotype distribution of the arrestin domain-containing 4 gene (ARRDC4) haplotypes in Caucasians. (PubMed id 18307387)1, 9 Knoll B....Kopke K. (2008)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A genome-wide association study of neuroticism in a p opulation-based sample. (PubMed id 20634892)1 Calboli F.C....Balding D.J. (2010)
- Thioredoxin-independent regulation of metabolism by t he alpha-arrestin proteins. (PubMed id 19605364)1 Patwari P....Lee R.T. (2009)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for ARRDC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing ARRDC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARRDC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARRDC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ARRDC4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARRDC4 gene: Search GeneIP for patents involving ARRDC4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ARRDC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for ARRDC4 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARRDC4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARRDC4 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for ARRDC4 | | OriGene 3'-UTR Clone for ARRDC4 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC4 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARRDC4 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARRDC4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARRDC4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARRDC4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARRDC4 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARRDC4 |
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 |  |  |  | |
| | | Search Tocris compounds for ARRDC4 |
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 | | ARRDC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC4 |
|  |  |  | | | ThermoFisher Antibodies for ARRDC4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC4 |
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