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Aliases for ARRDC4 Gene

Aliases for ARRDC4 Gene

  • Arrestin Domain Containing 4 2 3 5

External Ids for ARRDC4 Gene

Previous GeneCards Identifiers for ARRDC4 Gene

  • GC00U913742
  • GC15P096233
  • GC15P096304
  • GC15P098503
  • GC15P074633

Summaries for ARRDC4 Gene

GeneCards Summary for ARRDC4 Gene

ARRDC4 (Arrestin Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

UniProtKB/Swiss-Prot for ARRDC4 Gene

  • Adapter protein that may play a role in endocytosis and/or ubiquitination of activated G protein-coupled receptors (GPCRs) (Probable). When overexpressed, inhibits glucose uptake (PubMed:19605364).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC4 Gene

Genomics for ARRDC4 Gene

Regulatory Elements for ARRDC4 Gene

Enhancers for ARRDC4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARRDC4 on UCSC Golden Path with GeneCards custom track

Promoters for ARRDC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARRDC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARRDC4 Gene

97,960,698 bp from pter
97,973,838 bp from pter
13,141 bases
Plus strand

Genomic View for ARRDC4 Gene

Genes around ARRDC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC4 Gene

Proteins for ARRDC4 Gene

  • Protein details for ARRDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arrestin domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q6NSI9

    Protein attributes for ARRDC4 Gene

    418 amino acids
    Molecular mass:
    45479 Da
    Quaternary structure:
    • Interacts with ADRB2 (PubMed:21982743, PubMed:23208550). Interacts (via PPXY motifs) with ITCH, NEDD4L and WWP2 (PubMed:23236378). Interacts with AVPR2. Identified in a complex containing at least ARRDC4, AVPR2 and HGS (PubMed:23236378).

neXtProt entry for ARRDC4 Gene

Proteomics data for ARRDC4 Gene at MOPED

Post-translational modifications for ARRDC4 Gene

  • Ubiquitination at Lys 229
  • Modification sites at PhosphoSitePlus

Other Protein References for ARRDC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARRDC4 Gene

Domains & Families for ARRDC4 Gene

Protein Domains for ARRDC4 Gene

Suggested Antigen Peptide Sequences for ARRDC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the arrestin family.
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC4: view

No data available for Gene Families for ARRDC4 Gene

Function for ARRDC4 Gene

Molecular function for ARRDC4 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that may play a role in endocytosis and/or ubiquitination of activated G protein-coupled receptors (GPCRs) (Probable). When overexpressed, inhibits glucose uptake (PubMed:19605364).
genes like me logo Genes that share phenotypes with ARRDC4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARRDC4 Gene

Localization for ARRDC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARRDC4 Gene

Early endosome. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle.

Subcellular locations from

Jensen Localization Image for ARRDC4 Gene COMPARTMENTS Subcellular localization image for ARRDC4 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARRDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IDA 23236378
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with ARRDC4: view

Pathways & Interactions for ARRDC4 Gene

SuperPathways for ARRDC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARRDC4 Gene

Drugs & Compounds for ARRDC4 Gene

No Compound Related Data Available

Transcripts for ARRDC4 Gene

mRNA/cDNA for ARRDC4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARRDC4 Gene

Arrestin domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC4 Gene

No ASD Table

Relevant External Links for ARRDC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARRDC4 Gene

mRNA expression in normal human tissues for ARRDC4 Gene

mRNA differential expression in normal tissues according to GTEx for ARRDC4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.8).

Protein differential expression in normal tissues from HIPED for ARRDC4 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARRDC4 Gene

SOURCE GeneReport for Unigene cluster for ARRDC4 Gene Hs.6093

genes like me logo Genes that share expression patterns with ARRDC4: view

Protein tissue co-expression partners for ARRDC4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARRDC4 Gene

Orthologs for ARRDC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARRDC4 35
  • 87.91 (n)
  • 93.2 (a)
  • 93 (a)
(Canis familiaris)
Mammalia ARRDC4 35
  • 88.83 (n)
  • 92.7 (a)
  • 93 (a)
(Mus musculus)
Mammalia Arrdc4 35
  • 82.73 (n)
  • 86.75 (a)
Arrdc4 16
Arrdc4 36
  • 87 (a)
(Monodelphis domestica)
Mammalia ARRDC4 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia ARRDC4 36
  • 73 (a)
(Pan troglodytes)
Mammalia ARRDC4 36
  • 98 (a)
(Gallus gallus)
Aves ARRDC4 35
  • 75.06 (n)
  • 76.5 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia ARRDC4 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc4 35
  • 63.54 (n)
  • 61.68 (a)
(Danio rerio)
Actinopterygii arrdc3b 36
  • 48 (a)
si:ch211-130m23.2 36
  • 21 (a)
si:dkey-172m14.2 36
  • 29 (a)
zgc:110353 36
  • 27 (a)
zgc:110626 36
  • 21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vdup1 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea arrd-12 36
  • 22 (a)
arrd-16 36
  • 25 (a)
arrd-6 36
  • 20 (a)
Species with no ortholog for ARRDC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC4 Gene

Gene Tree for ARRDC4 (if available)
Gene Tree for ARRDC4 (if available)

Paralogs for ARRDC4 Gene

Paralogs for ARRDC4 Gene

(3) SIMAP similar genes for ARRDC4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARRDC4: view

Variants for ARRDC4 Gene

Sequence variations from dbSNP and Humsavar for ARRDC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs12101554 - 97,961,096(+) CCAGC(A/G)CCGCG reference, missense
rs17856817 - 97,970,039(+) AGCAG(C/T)CTGAA reference, missense
rs2130882 - 97,970,615(+) TGGTA(C/T)CAGAG reference, missense
rs4965046 -- 97,960,870(+) GGCGG(C/G)GAGGC reference, synonymous-codon
rs5814833 -- 97,969,393(+) AGCTC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARRDC4 Gene

Variant ID Type Subtype PubMed ID
nsv904538 CNV Loss 21882294

Variation tolerance for ARRDC4 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.82; 95.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARRDC4 Gene

Disorders for ARRDC4 Gene

Relevant External Links for ARRDC4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARRDC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC4 Gene

Publications for ARRDC4 Gene

  1. Mammalian I+ arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with I^ arrestins. (PMID: 23236378) Shea F.F. … Alvarez C.E. (PLoS ONE 2012) 3 4 67
  2. An anomalous haplotype distribution of the arrestin domain-containing 4 gene (ARRDC4) haplotypes in Caucasians. (PMID: 18307387) Knoll B. … KAPpke K. (Genet. Test. 2008) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. (PMID: 21897333) Irvin M.R. … Arnett D.K. (Pharmacogenet. Genomics 2011) 3
  5. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. (PMID: 21982743) Patwari P. … Lee R.T. (Cell Metab. 2011) 3

Products for ARRDC4 Gene

Sources for ARRDC4 Gene