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Aliases for ARRDC4 Gene

Aliases for ARRDC4 Gene

  • Arrestin Domain Containing 4 2 3

External Ids for ARRDC4 Gene

Previous GeneCards Identifiers for ARRDC4 Gene

  • GC00U913742
  • GC15P096233
  • GC15P096304
  • GC15P098503
  • GC15P074633

Summaries for ARRDC4 Gene

GeneCards Summary for ARRDC4 Gene

ARRDC4 (Arrestin Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC4 Gene

Genomics for ARRDC4 Gene

Regulatory Elements for ARRDC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARRDC4 Gene

97,960,698 bp from pter
97,973,838 bp from pter
13,141 bases
Plus strand

Genomic View for ARRDC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARRDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC4 Gene

Proteins for ARRDC4 Gene

  • Protein details for ARRDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arrestin domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q6NSI9

    Protein attributes for ARRDC4 Gene

    418 amino acids
    Molecular mass:
    45479 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARRDC4 Gene

Proteomics data for ARRDC4 Gene at MOPED

Post-translational modifications for ARRDC4 Gene

  • Ubiquitination at Lys229
  • Modification sites at PhosphoSitePlus

Other Protein References for ARRDC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARRDC4 Gene

Domains for ARRDC4 Gene

Protein Domains for ARRDC4 Gene

Suggested Antigen Peptide Sequences for ARRDC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the arrestin family.
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC4: view

No data available for Gene Families for ARRDC4 Gene

Function for ARRDC4 Gene

Phenotypes for ARRDC4 Gene

GenomeRNAi human phenotypes for ARRDC4:
genes like me logo Genes that share phenotypes with ARRDC4: view

Animal Model Products

miRNA for ARRDC4 Gene

miRTarBase miRNAs that target ARRDC4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARRDC4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ARRDC4 Gene

Localization for ARRDC4 Gene

Subcellular locations from

Jensen Localization Image for ARRDC4 Gene COMPARTMENTS Subcellular localization image for ARRDC4 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARRDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 23236378
GO:0005886 plasma membrane IDA 23236378
genes like me logo Genes that share ontologies with ARRDC4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARRDC4 Gene

Pathways for ARRDC4 Gene

SuperPathways for ARRDC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051443 positive regulation of ubiquitin-protein transferase activity IPI 23236378
genes like me logo Genes that share ontologies with ARRDC4: view

No data available for Pathways by source for ARRDC4 Gene

Transcripts for ARRDC4 Gene

mRNA/cDNA for ARRDC4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARRDC4 Gene

Arrestin domain containing 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARRDC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC4 Gene

No ASD Table

Relevant External Links for ARRDC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARRDC4 Gene

mRNA expression in normal human tissues for ARRDC4 Gene

mRNA differential expression in normal tissues according to GTEx for ARRDC4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.8).

Protein differential expression in normal tissues for ARRDC4 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARRDC4 Gene

SOURCE GeneReport for Unigene cluster for ARRDC4 Gene Hs.6093

genes like me logo Genes that share expressions with ARRDC4: view

Expression partners for ARRDC4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARRDC4 Gene

Orthologs for ARRDC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARRDC4 35
  • 87.91 (n)
  • 93.2 (a)
  • 93 (a)
(Canis familiaris)
Mammalia ARRDC4 35
  • 88.83 (n)
  • 92.7 (a)
  • 93 (a)
(Mus musculus)
Mammalia Arrdc4 35
  • 82.73 (n)
  • 86.75 (a)
Arrdc4 16
Arrdc4 36
  • 87 (a)
(Monodelphis domestica)
Mammalia ARRDC4 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia ARRDC4 36
  • 73 (a)
(Pan troglodytes)
Mammalia ARRDC4 36
  • 98 (a)
(Gallus gallus)
Aves ARRDC4 35
  • 75.06 (n)
  • 76.5 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia ARRDC4 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc4 35
  • 63.54 (n)
  • 61.68 (a)
(Danio rerio)
Actinopterygii arrdc3b 36
  • 48 (a)
si:ch211-130m23.2 36
  • 21 (a)
si:dkey-172m14.2 36
  • 29 (a)
zgc:110353 36
  • 27 (a)
zgc:110626 36
  • 21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vdup1 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea arrd-12 36
  • 22 (a)
arrd-16 36
  • 25 (a)
arrd-6 36
  • 20 (a)
Species with no ortholog for ARRDC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC4 Gene

Gene Tree for ARRDC4 (if available)
Gene Tree for ARRDC4 (if available)

Paralogs for ARRDC4 Gene

Paralogs for ARRDC4 Gene

(3) SIMAP similar genes for ARRDC4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARRDC4: view

Variants for ARRDC4 Gene

Sequence variations from dbSNP and Humsavar for ARRDC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1032351 -- 97,967,182(+) TAGAA(A/T)TGGGA intron-variant
rs1043366 -- 97,972,393(+) TGTTT(A/T)AACTG utr-variant-3-prime
rs1043372 -- 97,972,903(+) AGCAT(C/T)GTGCA utr-variant-3-prime
rs1043374 -- 97,973,392(+) TTGAA(A/C)TGATA utr-variant-3-prime
rs1043382 -- 97,973,522(+) TTGGT(A/C/G/T)ATTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARRDC4 Gene

Variant ID Type Subtype PubMed ID
nsv904538 CNV Loss 21882294

Relevant External Links for ARRDC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC4 Gene

Disorders for ARRDC4 Gene

(1) University of Copenhagen DISEASES for ARRDC4 Gene

Relevant External Links for ARRDC4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ARRDC4: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ARRDC4 Gene

Publications for ARRDC4 Gene

  1. A genome-wide association study of neuroticism in a population-based sample. (PMID: 20634892) Calboli F.C. … Balding D.J. (PLoS ONE 2010) 3 48
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. An anomalous haplotype distribution of the arrestin domain-containing 4 gene (ARRDC4) haplotypes in Caucasians. (PMID: 18307387) Knoll B. … KAPpke K. (Genet. Test. 2008) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ARRDC4 Gene

Sources for ARRDC4 Gene

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