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Aliases for ARRDC4 Gene

Aliases for ARRDC4 Gene

  • Arrestin Domain Containing 4 2 3 5

External Ids for ARRDC4 Gene

Previous GeneCards Identifiers for ARRDC4 Gene

  • GC00U913742
  • GC15P096233
  • GC15P096304
  • GC15P098503
  • GC15P074633

Summaries for ARRDC4 Gene

GeneCards Summary for ARRDC4 Gene

ARRDC4 (Arrestin Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is ARRDC3.

UniProtKB/Swiss-Prot for ARRDC4 Gene

  • Adapter protein that may play a role in endocytosis and/or ubiquitination of activated G protein-coupled receptors (GPCRs) (Probable). When overexpressed, inhibits glucose uptake (PubMed:19605364).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC4 Gene

Genomics for ARRDC4 Gene

Regulatory Elements for ARRDC4 Gene

Enhancers for ARRDC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G097959 1.1 ENCODE 50.6 +0.5 509 3.4 PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A FEZF1 ZBTB7B YY1 FOS ARRDC4 LINC02251 ENSG00000259478
GH15G098002 1.4 FANTOM5 ENCODE 37.9 +42.9 42924 2.8 PKNOX1 FOXA2 ARID4B SIN3A GLI4 YBX1 FEZF1 ZNF2 ZNF48 GLIS2 ARRDC4 LINC02251 LOC101927310 LOC105371009
GH15G097976 1.4 FANTOM5 Ensembl ENCODE 28.5 +17.0 17043 2.9 ZBTB40 RAD21 RARA YY1 TCF12 ZNF366 ELK1 GATA2 FOS ZNF263 ARRDC4 LINC02251 LOC101927310 ENSG00000259478
GH15G097991 1.2 Ensembl ENCODE 28.9 +32.3 32285 2.0 HDAC1 PKNOX1 ATF1 TBL1XR1 TCF12 ZNF766 GATA2 FOS ETV6 PCBP1 ARRDC4 LINC02251 ENSG00000259478
GH15G097994 0.8 Ensembl ENCODE 28.4 +35.2 35179 2.0 CTCF L3MBTL2 IKZF1 SMC3 HNF4A RAD21 MGA ARRDC4 ENSG00000259478 LINC02251
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARRDC4 on UCSC Golden Path with GeneCards custom track

Promoters for ARRDC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000081641 302 2401 PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A FEZF1 ZBTB7B YY1 FOS

Genomic Location for ARRDC4 Gene

Chromosome:
15
Start:
97,960,698 bp from pter
End:
97,973,838 bp from pter
Size:
13,141 bases
Orientation:
Plus strand

Genomic View for ARRDC4 Gene

Genes around ARRDC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC4 Gene

Proteins for ARRDC4 Gene

  • Protein details for ARRDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCT1-ARRD4_HUMAN
    Recommended name:
    Arrestin domain-containing protein 4
    Protein Accession:
    Q8NCT1
    Secondary Accessions:
    • Q6NSI9

    Protein attributes for ARRDC4 Gene

    Size:
    418 amino acids
    Molecular mass:
    45479 Da
    Quaternary structure:
    • Interacts with ADRB2 (PubMed:21982743, PubMed:23208550). Interacts (via PPXY motifs) with ITCH, NEDD4L and WWP2 (PubMed:23236378). Interacts with AVPR2. Identified in a complex containing at least ARRDC4, AVPR2 and HGS (PubMed:23236378).

neXtProt entry for ARRDC4 Gene

Post-translational modifications for ARRDC4 Gene

  • Ubiquitination at posLast=229229
  • Modification sites at PhosphoSitePlus

Other Protein References for ARRDC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARRDC4 Gene

Domains & Families for ARRDC4 Gene

Gene Families for ARRDC4 Gene

Protein Domains for ARRDC4 Gene

Suggested Antigen Peptide Sequences for ARRDC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCT1

UniProtKB/Swiss-Prot:

ARRD4_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC4: view

Function for ARRDC4 Gene

Molecular function for ARRDC4 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that may play a role in endocytosis and/or ubiquitination of activated G protein-coupled receptors (GPCRs) (Probable). When overexpressed, inhibits glucose uptake (PubMed:19605364).

Gene Ontology (GO) - Molecular Function for ARRDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23236378
genes like me logo Genes that share ontologies with ARRDC4: view
genes like me logo Genes that share phenotypes with ARRDC4: view

Animal Models for ARRDC4 Gene

MGI Knock Outs for ARRDC4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARRDC4 Gene

Localization for ARRDC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARRDC4 Gene

Early endosome. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARRDC4 gene
Compartment Confidence
plasma membrane 5
endosome 5
mitochondrion 2
cytosol 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARRDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 23236378
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IDA 23236378
GO:0016020 membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ARRDC4: view

Pathways & Interactions for ARRDC4 Gene

SuperPathways for ARRDC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051443 positive regulation of ubiquitin-protein transferase activity IPI 23236378
genes like me logo Genes that share ontologies with ARRDC4: view

No data available for Pathways by source and SIGNOR curated interactions for ARRDC4 Gene

Drugs & Compounds for ARRDC4 Gene

No Compound Related Data Available

Transcripts for ARRDC4 Gene

mRNA/cDNA for ARRDC4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARRDC4 Gene

Arrestin domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC4 Gene

No ASD Table

Relevant External Links for ARRDC4 Gene

GeneLoc Exon Structure for
ARRDC4
ECgene alternative splicing isoforms for
ARRDC4

Expression for ARRDC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARRDC4 Gene

mRNA differential expression in normal tissues according to GTEx for ARRDC4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.8).

Protein differential expression in normal tissues from HIPED for ARRDC4 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARRDC4 Gene



Protein tissue co-expression partners for ARRDC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARRDC4 Gene:

ARRDC4

SOURCE GeneReport for Unigene cluster for ARRDC4 Gene:

Hs.6093

Evidence on tissue expression from TISSUES for ARRDC4 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with ARRDC4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARRDC4 Gene

Orthologs for ARRDC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARRDC4 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARRDC4 34 35
  • 88.83 (n)
cow
(Bos Taurus)
Mammalia ARRDC4 34 35
  • 87.91 (n)
oppossum
(Monodelphis domestica)
Mammalia ARRDC4 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arrdc4 34 16 35
  • 82.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARRDC4 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARRDC4 34 35
  • 75.06 (n)
lizard
(Anolis carolinensis)
Reptilia ARRDC4 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc4 34
  • 63.54 (n)
zebrafish
(Danio rerio)
Actinopterygii arrdc3b 35
  • 48 (a)
ManyToMany
si:dkey-172m14.2 35
  • 29 (a)
ManyToMany
zgc:110353 35
  • 27 (a)
ManyToMany
si:ch211-130m23.2 35
  • 21 (a)
ManyToMany
zgc:110626 35
  • 21 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Vdup1 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arrd-16 35
  • 25 (a)
ManyToMany
arrd-12 35
  • 22 (a)
ManyToMany
arrd-6 35
  • 20 (a)
ManyToMany
Species where no ortholog for ARRDC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC4 Gene

ENSEMBL:
Gene Tree for ARRDC4 (if available)
TreeFam:
Gene Tree for ARRDC4 (if available)

Paralogs for ARRDC4 Gene

Paralogs for ARRDC4 Gene

(3) SIMAP similar genes for ARRDC4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARRDC4: view

Variants for ARRDC4 Gene

Sequence variations from dbSNP and Humsavar for ARRDC4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000098529 -- 97,968,961(+) GCAGT(C/G)AATTT intron-variant
rs1000359411 -- 97,966,661(+) AGGCT(A/G)TAAGT intron-variant
rs1000711304 -- 97,965,425(+) CATAG(-/AC)ACACG intron-variant
rs1000797766 -- 97,963,437(+) CTCAT(A/T)TTAAA intron-variant
rs1001107014 -- 97,970,378(+) CTATA(C/T)CTCAA intron-variant

Variation tolerance for ARRDC4 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.82; 95.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARRDC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARRDC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARRDC4 Gene

Disorders for ARRDC4 Gene

Relevant External Links for ARRDC4

Genetic Association Database (GAD)
ARRDC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARRDC4

No disorders were found for ARRDC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC4 Gene

Publications for ARRDC4 Gene

  1. Mammalian I+ arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with I^ arrestins. (PMID: 23236378) Shea F.F. … Alvarez C.E. (PLoS ONE 2012) 3 4 64
  2. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. (PMID: 21982743) Patwari P. … Lee R.T. (Cell Metab. 2011) 3 4 64
  3. A genome-wide association study of neuroticism in a population-based sample. (PMID: 20634892) Calboli F.C. … Balding D.J. (PLoS ONE 2010) 3 46 64
  4. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. (PMID: 19605364) Patwari P. … Lee R.T. (J. Biol. Chem. 2009) 3 4 64
  5. An anomalous haplotype distribution of the arrestin domain-containing 4 gene (ARRDC4) haplotypes in Caucasians. (PMID: 18307387) Knoll B. … KAPpke K. (Genet. Test. 2008) 3 22 64

Products for ARRDC4 Gene

Sources for ARRDC4 Gene

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