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ARRDC4 Gene

protein-coding   GIFtS: 49
GCID: GC15P098503

Arrestin Domain Containing 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arrestin Domain Containing 41 2
Arrestin Domain-Containing Protein 42

External Ids:    HGNC: 280871   Entrez Gene: 919472   Ensembl: ENSG000001404507   UniProtKB: Q8NCT13   

Export aliases for ARRDC4 gene to outside databases

Previous GC identifers: GC00U913742 GC15P096233 GC15P096304 GC15P074633


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARRDC4 Gene:
ARRDC4 (arrestin domain containing 4) is a protein-coding gene. Diseases associated with ARRDC4 include congenital diaphragmatic hernia, and lactic acidosis. An important paralog of this gene is TXNIP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARRDC4 gene promoter:
         POU2F2 (Oct-2.1)   E2F-4   E2F-3a   Oct-B1   E2F-5   E2F-2   POU2F2   POU2F2C   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARRDC4 promoter sequence
   Search Chromatin IP Primers for ARRDC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARRDC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.2   HGNC cytogenetic band: 15q26.2

ARRDC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARRDC4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P098503:  view genomic region     (about GC identifiers)

Start:
98,462,784 bp from pter      End:
98,517,068 bp from pter
Size:
54,285 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARRD4_HUMAN, Q8NCT1 (See protein sequence)
Recommended Name: Arrestin domain-containing protein 4  
Size: 418 amino acids; 45479 Da
Secondary accessions: Q6NSI9

Explore the universe of human proteins at neXtProt for ARRDC4: NX_Q8NCT1

Explore proteomics data for ARRDC4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys229
  • Modification sites at PhosphoSitePlus

  • See ARRDC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_899232.2  
    ENSEMBL proteins: 
     ENSP00000268042   ENSP00000443774  

    ARRDC4 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ARRDC4

    ARRDC4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ARRDC4
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    ThermoFisher Antibodies for ARRDC4
    LSBio Antibodies in human, mouse, rat for ARRDC4

    ARRDC4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ARRDC4
    Cloud-Clone Corp. CLIAs for ARRDC4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR011022 Arrestin_C-like
     IPR011021 Arrestin-like_N

    Graphical View of Domain Structure for InterPro Entry Q8NCT1

    ProtoNet protein and cluster: Q8NCT1

    UniProtKB/Swiss-Prot: ARRD4_HUMAN, Q8NCT1
    Similarity: Belongs to the arrestin family


    ARRDC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for ARRDC4:
     Decreased nuclei size in G2M  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARRDC4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARRDC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARRDC4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARRDC4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARRDC4:
    hsa-mir-324-3p (MIRT042875), hsa-let-7d-5p (MIRT032160), hsa-mir-32-5p (MIRT028347)

    Block miRNA regulation of human, mouse, rat ARRDC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARRDC4 (see all 32):
    hsa-let-7d hsa-miR-29a hsa-miR-25 hsa-miR-128 hsa-miR-1273d hsa-let-7g hsa-let-7a hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidARRDC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARRDC4
    Predesigned siRNA for gene silencing in human, mouse, rat ARRDC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARRDC4

    Clone
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    OriGene clones in human, mouse for ARRDC4 (see all 6)
    OriGene ORF clones in mouse, rat for ARRDC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARRDC4 (NM_183376)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARRDC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ARRDC4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA--
    GO:0005886plasma membrane IDA--

    ARRDC4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARRDC4
    Interactions:

        Search GeneGlobe Interaction Network for ARRDC4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ARRDC4 (ENSP000002680424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DUS2ENSP000003517694STRING: ENSP00000351769
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051443positive regulation of ubiquitin-protein ligase activity IPI--

    ARRDC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARRDC4 (ARRD4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARRDC4 gene: 
    NM_183376.2  

    Unigene Cluster for ARRDC4:

    Arrestin domain containing 4
    Hs.6093  [show with all ESTs]
    Unigene Representative Sequence: NM_183376
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268042(uc002bui.4 uc010bom.3) ENST00000538249
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARRDC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARRDC4 (see all 32):
    hsa-let-7d hsa-miR-29a hsa-miR-25 hsa-miR-128 hsa-miR-1273d hsa-let-7g hsa-let-7a hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidARRDC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARRDC4
    Predesigned siRNA for gene silencing in human, mouse, rat ARRDC4
    Clone
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    OriGene clones in human, mouse for ARRDC4 (see all 6)
    OriGene ORF clones in mouse, rat for ARRDC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARRDC4 (NM_183376)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARRDC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARRDC4
    OriGene qSTAR qPCR primer pairs in human, mouse for ARRDC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARRDC4
      QuantiTect SYBR Green Assays in human, mouse, rat ARRDC4
      QuantiFast Probe-based Assays in human, mouse, rat ARRDC4

    Additional mRNA sequence: 

    AK026436.1 AK093364.1 AK290221.1 AK296448.1 AK316280.1 BC028704.2 BC038453.1 BC070100.1 

    4 DOTS entries:

    DT.453161  DT.91790153  DT.100657968  DT.75121542 

    Selected AceView cDNA sequences (see all 125):

    BU630296 BX501397 BX284073 AA149653 BM450159 Z45082 AA345595 CA424243 
    AA361701 BF439394 CK819123 AI831098 AI377076 AA937448 CK819122 AI753503 
    AK093364 AI332879 BG698137 AI867993 BI770251 CB850502 AI831425 AX748078 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARRDC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGGTGCA
    ARRDC4 Expression
    About this image

    ARRDC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARRDC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6093
        Custom PCR Arrays for ARRDC4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARRDC4
    OriGene qSTAR qPCR primer pairs in human, mouse for ARRDC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARRDC4
    QuantiTect SYBR Green Assays in human, mouse, rat ARRDC4
    QuantiFast Probe-based Assays in human, mouse, rat ARRDC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARRDC4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arrdc41 , 5 arrestin domain containing 41, 5 82.73(n)1
    86.75(a)1
      7 (37.81 cM)5
    664121  NM_001042592.21  NP_001036057.11 
     687370455 
    chicken
    (Gallus gallus)
    Aves ARRDC41 arrestin domain containing 4 75.06(n)
    76.5(a)
      415509  XM_413881.4  XP_413881.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARRDC46
    arrestin domain containing 4
    69(a)
    1 ↔ 1
    GL343363.1(942808-961857)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arrdc41 arrestin domain containing 4 63.54(n)
    61.68(a)
      100135736  NM_001114260.1  NP_001107732.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arrdc3b6
    si:dkey-172m14.26
    (see all 5)
    si:dkey-172m14.2
    (see all 5)
    48(a)
    29(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    10(45263620-45273587) ENSDARG00000036028
    5(50789967-50794703) ENSDARG00000067664
    fruit fly
    (Drosophila melanogaster)
    Insecta Vdup16
    Vitamin D[[3]] up-regulated protein 1
    27(a)
    1 → many
    3L(176306-178963)
    worm
    (Caenorhabditis elegans)
    Secernentea arrd-166
    arrd-126
    (see all 3)
    Protein ARRD-12 (arrd-12) mRNA, complete cds
    (see all 3)
    25(a)
    22(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(12484732-12488343) WBGene00013043
    II(13766318-13768403) WBGene00011053


    ENSEMBL Gene Tree for ARRDC4 (if available)
    TreeFam Gene Tree for ARRDC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARRDC4 gene
    TXNIP2  ARRDC12  ARRDC32  ARRDC22  
    3 SIMAP similar genes for ARRDC4 using alignment to 2 protein entries:     ARRD4_HUMAN (see all proteins):
    ARRDC3    TXNIP    ARRDC2

    ARRDC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARRDC4 (see all 455)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs96730981,2
    C,F,H--98501987(+) CACTGC/AAAACC 1 -- us2k17Minor allele frequency- A:0.23NA WA CSA 13
    rs346306101,2
    C,F--98501994(+) AACCTC/TCGCCT 1 -- us2k13Minor allele frequency- T:0.33NA 6
    rs1813543901,2
    --98502004(+) TCCCGC/GGTTCA 1 -- us2k10--------
    rs1854391741,2
    --98502160(+) GCCTCA/GGCCTC 1 -- us2k10--------
    rs1898531961,2
    --98502288(+) TTGTCC/TTTTCA 1 -- us2k10--------
    rs1392589261,2
    --98502298(+) ATTACA/CGTTAG 1 -- us2k10--------
    rs785876661,2
    C--98502299(+) TTACCG/TTTAGG 1 -- us2k10--------
    rs1824950891,2
    --98502332(+) CCCAGA/CCACTT 1 -- us2k10--------
    rs1891506961,2
    --98502379(+) TTTAGC/TAGAGT 1 -- us2k10--------
    rs1158872351,2
    F--98502443(+) GATACA/GTCATT 1 -- us2k11Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for ARRDC4 (98462784 - 98517068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARRDC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904538CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARRDC4
    DNA2.0 Custom Variant and Variant Library Synthesis for ARRDC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for ARRDC4:    
    About MalaCards
    congenital diaphragmatic hernia    lactic acidosis    type 1 diabetes    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for ARRDC4:
    Congenital diaphragmatic hernia

    ARRDC4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARRDC4

    Export disorders for ARRDC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARRDC4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ARRDC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of neuroticism in a population-based sample. (PubMed id 20634892)1, 4 Calboli F.C....Balding D.J. (PLoS ONE 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. An anomalous haplotype distribution of the arrestin domain-containing 4 gene (ARRDC4) haplotypes in Caucasians. (PubMed id 18307387)1, 9 Knoll B....KAPpke K. (Genet. Test. 2008)
    5. Mammalian I+ arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with I^ arrestins. (PubMed id 23236378)1 Shea F.F....Alvarez C.E. (PLoS ONE 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. (PubMed id 21897333)1 Irvin M.R....Arnett D.K. (Pharmacogenet. Genomics 2011)
    8. Genome-wide population-based association study of extremely overweight young adults--the GOYA study. (PubMed id 21935397)4 Paternoster L....rensen T.I. (PLoS ONE 2011)
    9. A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. (PubMed id 19875614)4 Paterson A.D....Bull S.B. (Diabetes 2010)
    10. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. (PubMed id 19605364)1 Patwari P....Lee R.T. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91947 HGNC: 28087 AceView: ARRDC4 Ensembl:ENSG00000140450 euGenes: HUgn91947
    ECgene: ARRDC4 H-InvDB: ARRDC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARRDC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARRDC4 gene:
    Search GeneIP for patents involving ARRDC4

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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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