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Aliases for ARRDC3 Gene

Aliases for ARRDC3 Gene

  • Arrestin Domain Containing 3 2 3
  • TBP-2-Like Inducible Membrane Protein 3 4
  • Alpha-Arrestin 3 2 3
  • TLIMP 3 4
  • Thioredoxin-Binding Protein-2-Like Inducible Membrane 3
  • KIAA1376 4

External Ids for ARRDC3 Gene

Previous GeneCards Identifiers for ARRDC3 Gene

  • GC00U913741
  • GC05M090749
  • GC05M090700
  • GC05M085876
  • GC05M090664

Summaries for ARRDC3 Gene

GeneCards Summary for ARRDC3 Gene

ARRDC3 (Arrestin Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include beta-3 adrenergic receptor binding. An important paralog of this gene is ARRDC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC3 Gene

Genomics for ARRDC3 Gene

Regulatory Elements for ARRDC3 Gene

Genomic Location for ARRDC3 Gene

91,368,724 bp from pter
91,383,359 bp from pter
14,636 bases
Minus strand

Genomic View for ARRDC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARRDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC3 Gene

Proteins for ARRDC3 Gene

  • Protein details for ARRDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arrestin domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K6T8
    • Q9P2H1

    Protein attributes for ARRDC3 Gene

    414 amino acids
    Molecular mass:
    46395 Da
    Quaternary structure:
    • Does not bind TXN (thioredoxin)
    • Sequence=BAA92614.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARRDC3 Gene

neXtProt entry for ARRDC3 Gene

Proteomics data for ARRDC3 Gene at MOPED

Post-translational modifications for ARRDC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARRDC3 Gene

Domains & Families for ARRDC3 Gene

Protein Domains for ARRDC3 Gene

Suggested Antigen Peptide Sequences for ARRDC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the arrestin family.
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC3: view

No data available for Gene Families for ARRDC3 Gene

Function for ARRDC3 Gene

Molecular function for ARRDC3 Gene

UniProtKB/Swiss-Prot Induction:
By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041 (a PPARD ligand), by vitamin D3 and, to a lesser extent, by phorbol myristate acetate (PMA) in the promyelocytic leukemia HL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist).

Gene Ontology (GO) - Molecular Function for ARRDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20603614
GO:0031699 beta-3 adrenergic receptor binding IDA 21982743
genes like me logo Genes that share ontologies with ARRDC3: view
genes like me logo Genes that share phenotypes with ARRDC3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARRDC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARRDC3 Gene

Localization for ARRDC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARRDC3 Gene

Cytoplasm. Note=Associated with plasma membrane, as well as with endodomes and lysosomes during endocytosis.

Subcellular locations from

Jensen Localization Image for ARRDC3 Gene COMPARTMENTS Subcellular localization image for ARRDC3 gene
Compartment Confidence
endosome 5
plasma membrane 5
lysosome 1

Gene Ontology (GO) - Cellular Components for ARRDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 23236378
GO:0005886 plasma membrane IDA 23236378
genes like me logo Genes that share ontologies with ARRDC3: view

Pathways & Interactions for ARRDC3 Gene

SuperPathways for ARRDC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0031651 negative regulation of heat generation IEA --
GO:0043588 skin development IEA --
GO:0044252 negative regulation of multicellular organismal metabolic process IEA --
GO:0051443 positive regulation of ubiquitin-protein transferase activity IPI 23236378
genes like me logo Genes that share ontologies with ARRDC3: view

No data available for Pathways by source and SIGNOR curated interactions for ARRDC3 Gene

Drugs & Compounds for ARRDC3 Gene

No Compound Related Data Available

Transcripts for ARRDC3 Gene

Unigene Clusters for ARRDC3 Gene

Arrestin domain containing 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARRDC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -
SP6: - - - -

Relevant External Links for ARRDC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARRDC3 Gene

mRNA expression in normal human tissues for ARRDC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARRDC3 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARRDC3 Gene

SOURCE GeneReport for Unigene cluster for ARRDC3 Gene Hs.24684

mRNA Expression by UniProt/SwissProt for ARRDC3 Gene

Tissue specificity: Highly expressed in skeletal muscle, placenta, kidney, adrenal gland, lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes.
genes like me logo Genes that share expression patterns with ARRDC3: view

Protein tissue co-expression partners for ARRDC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARRDC3 Gene

Orthologs for ARRDC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARRDC3 35
  • 96.62 (n)
  • 98.79 (a)
  • 99 (a)
(Canis familiaris)
Mammalia ARRDC3 35
  • 96.78 (n)
  • 99.03 (a)
  • 99 (a)
(Mus musculus)
Mammalia Arrdc3 35
  • 92.67 (n)
  • 98.07 (a)
Arrdc3 16
Arrdc3 36
  • 98 (a)
(Pan troglodytes)
Mammalia ARRDC3 35
  • 99.92 (n)
  • 99.76 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arrdc3 35
  • 93.56 (n)
  • 98.07 (a)
(Monodelphis domestica)
Mammalia ARRDC3 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia ARRDC3 36
  • 95 (a)
(Gallus gallus)
Aves ARRDC3 35
  • 87.12 (n)
  • 96.38 (a)
  • 94 (a)
(Anolis carolinensis)
Reptilia ARRDC3 36
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc3 35
  • 83.58 (n)
  • 92.48 (a)
Str.3902 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17848 35
(Danio rerio)
Actinopterygii arrdc3a 35
  • 77.4 (n)
  • 87.07 (a)
wufc21e01 35
arrdc3a 36
  • 86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5882 35
fruit fly
(Drosophila melanogaster)
Insecta Vdup1 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea arrd-12 36
  • 23 (a)
arrd-16 36
  • 24 (a)
arrd-6 36
  • 21 (a)
Species with no ortholog for ARRDC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC3 Gene

Gene Tree for ARRDC3 (if available)
Gene Tree for ARRDC3 (if available)

Paralogs for ARRDC3 Gene

Paralogs for ARRDC3 Gene

(3) SIMAP similar genes for ARRDC3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARRDC3: view

Variants for ARRDC3 Gene

Variation tolerance for ARRDC3 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARRDC3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for ARRDC3 Gene

Disorders for ARRDC3 Gene

Relevant External Links for ARRDC3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARRDC3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC3 Gene

Publications for ARRDC3 Gene

  1. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. (PMID: 19605364) Patwari P. … Lee R.T. (J. Biol. Chem. 2009) 2 67
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  3. Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). (PMID: 24379409) Qi S. … Hurley J.H. (J. Biol. Chem. 2014) 67
  4. Insights into I^2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. (PMID: 25220262) Qi S. … Hurley J.H. (Protein Sci. 2014) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for ARRDC3 Gene

Sources for ARRDC3 Gene

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