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ARRDC3 Gene

protein-coding   GIFtS: 50
GCID: GC05M090664

Arrestin Domain Containing 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arrestin Domain Containing 31 2     KIAA13763 5
TLIMP2 3 5     Arrestin Domain-Containing Protein 32
Alpha-Arrestin 31 2     Thioredoxin-Binding Protein-2-Like Inducible Membrane2
TBP-2-Like Inducible Membrane Protein2 3     

External Ids:    HGNC: 292631   Entrez Gene: 575612   Ensembl: ENSG000001133697   OMIM: 6124645   UniProtKB: Q96B673   

Export aliases for ARRDC3 gene to outside databases

Previous GC identifers: GC00U913741 GC05M090749 GC05M090700 GC05M085876


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARRDC3 Gene:
ARRDC3 (arrestin domain containing 3) is a protein-coding gene. GO annotations related to this gene include beta-3 adrenergic receptor binding. An important paralog of this gene is TXNIP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARRDC3 gene promoter:
         ATF-2   Nkx2-5   Meis-1b   Gfi-1   Egr-2   POU2F1   POU2F1a   c-Jun   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARRDC3 promoter sequence
   Search Chromatin IP Primers for ARRDC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARRDC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.3   Ensembl cytogenetic band:  5q14.3   HGNC cytogenetic band: 5q14.3

ARRDC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARRDC3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M090664:  view genomic region     (about GC identifiers)

Start:
90,664,541 bp from pter      End:
90,679,176 bp from pter
Size:
14,636 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARRD3_HUMAN, Q96B67 (See protein sequence)
Recommended Name: Arrestin domain-containing protein 3  
Size: 414 amino acids; 46395 Da
Subunit: Does not bind TXN (thioredoxin)
Sequence caution: Sequence=BAA92614.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ARRDC3:
4N7H (3D)    
Secondary accessions: A8K6T8 Q9P2H1

Explore the universe of human proteins at neXtProt for ARRDC3: NX_Q96B67

Explore proteomics data for ARRDC3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARRDC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065852.1  
    ENSEMBL proteins: 
     ENSP00000265138  

    ARRDC3 Human Recombinant Protein Products:

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    antibodies-online proteins for ARRDC3 (5 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR011022 Arrestin_C-like
     IPR011021 Arrestin-like_N

    Graphical View of Domain Structure for InterPro Entry Q96B67

    ProtoNet protein and cluster: Q96B67

    UniProtKB/Swiss-Prot: ARRD3_HUMAN, Q96B67
    Similarity: Belongs to the arrestin family


    Find genes that share domains with ARRDC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARRD3_HUMAN, Q96B67
    Induction: By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041
    (a PPARD ligand), by vitamin D3 and, to a lesser extent, by phorbol myristate acetate (PMA) in the promyelocytic
    leukemia HL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0031699beta-3 adrenergic receptor binding IDA--
         
    Find genes that share ontologies with ARRDC3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARRDC3:
     Increased HPV18 LCR reporter a 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arrdc3):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging 

    Find genes that share phenotypes with ARRDC3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARRDC3

    miRNA
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    miRTarBase miRNAs that target ARRDC3:
    hsa-mir-148a-3p (MIRT026009), hsa-let-7a-5p (MIRT052564), hsa-mir-19b-3p (MIRT031205), hsa-mir-335-5p (MIRT017348), hsa-mir-130b-3p (MIRT020215)

    Block miRNA regulation of human, mouse, rat ARRDC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARRDC3 (see all 86):
    hsa-miR-607 hsa-miR-4325 hsa-miR-3622b-3p hsa-miR-4274 hsa-miR-3148 hsa-miR-200b hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidARRDC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARRDC3

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    Addgene plasmids for ARRDC3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARRD3_HUMAN, Q96B67: Cytoplasm. Note=Associated with plasma membrane, as well as with endodomes and lysosomes
    during endocytosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with ARRDC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARRDC3
    Interactions:

        Search GeneGlobe Interaction Network for ARRDC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARRDC3 (Q96B671, 2, 3 ENSP000002651384) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRB2P075502, 3, ENSP000003053724MINT-8430169 MINT-8430222 I2D: score=1 STRING: ENSP00000305372
    ITGB4P161441, 3, ENSP000002001814EBI-2875665,EBI-948678 I2D: score=3 STRING: ENSP00000200181
    NEDD4P469342, 3, ENSP000003455304MINT-8428852 I2D: score=1 STRING: ENSP00000345530
    HGSO149642MINT-8428911 MINT-8429022
    GCH1P307933I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis IEA--
    GO:0031651negative regulation of heat generation IEA--
    GO:0044252negative regulation of multicellular organismal metabolic process IEA--
    GO:0051443positive regulation of ubiquitin-protein ligase activity IPI--
    GO:0060613fat pad development IEA--

    Find genes that share ontologies with ARRDC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARRDC3 (ARRD3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARRDC3 gene: 
    NM_020801.2  

    Unigene Cluster for ARRDC3:

    Arrestin domain containing 3
    Hs.24684  [show with all ESTs]
    Unigene Representative Sequence: NM_020801
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265138(uc003kjz.2) ENST00000511391 ENST00000505631 ENST00000514284
    ENST00000508948 ENST00000503192 ENST00000507075
    miRNA
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    Block miRNA regulation of human, mouse, rat ARRDC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARRDC3 (see all 86):
    hsa-miR-607 hsa-miR-4325 hsa-miR-3622b-3p hsa-miR-4274 hsa-miR-3148 hsa-miR-200b hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidARRDC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARRDC3
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    OriGene ORF clones in mouse, rat for ARRDC3
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    GenScript: all cDNA clones in your preferred vector: ARRDC3 (NM_020801)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARRDC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC3
    Addgene plasmids for ARRDC3 
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    OriGene qPCR primer pairs and template standards for ARRDC3
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      QuantiTect SYBR Green Assays in human, mouse, rat ARRDC3
      QuantiFast Probe-based Assays in human, mouse, rat ARRDC3

    Additional mRNA sequence: 

    AB037797.1 AK025028.1 AK026917.1 AK291753.1 BC015928.2 BC053619.1 

    12 DOTS entries:

    DT.444441  DT.101982388  DT.91664773  DT.92045430  DT.99962199  DT.100799420  DT.429724  DT.100796664 
    DT.100796665  DT.91712127  DT.95356564  DT.40210289 

    Selected AceView cDNA sequences (see all 202):

    AA862534 T07060 AK025028 CA415872 AW613677 AB037797 C01622 BM977436 
    BM893862 AA872631 AL543552 BM467761 AA604775 AV702495 BQ428339 AW572645 
    BC053619 CK300105 AA724014 CK823447 AI475418 CR608314 BM128892 CR596450 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
    SP1:                    -     -     -     -                 -                 -                                             
    SP2:                    -     -     -     -           -     -                 -                                             
    SP3:                          -     -     -                 -                                                               
    SP4:                                                        -                                                               
    SP5:                                      -           -     -                 -                                             


    ECgene alternative splicing isoforms for ARRDC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARRDC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARRDC3 Expression
    About this image


    ARRDC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
     
     Adrenal Gland (Endocrine System)
    ARRDC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARRDC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24684

    UniProtKB/Swiss-Prot: ARRD3_HUMAN, Q96B67
    Tissue specificity: Highly expressed in skeletal muscle, placenta, kidney, adrenal gland, lymph node, mammary
    gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow.
    Strong expression in differentiated adipocytes compared to preadipocytes

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    QuantiFast Probe-based Assays in human, mouse, rat ARRDC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARRDC3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arrdc31 , 5 arrestin domain containing 31, 5 92.67(n)1
    98.07(a)1
      13 (41.95 cM)5
    1051711  NM_001042591.11  NP_001036056.11 
     808833845 
    chicken
    (Gallus gallus)
    Aves ARRDC31 arrestin domain containing 3 87.12(n)
    96.38(a)
      427107  XM_424699.3  XP_424699.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARRDC36
    arrestin domain containing 3
    97(a)
    1 ↔ 1
    2(23370024-23390130)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.178482 Xenopus laevis transcribed sequence with weak similarity more 78.8(n)    48037388 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc21e012 wufc21e01 77.87(n)   324193  CD758474.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vdup16
    Vitamin D[[3]] up-regulated protein 1
    27(a)
    1 → many
    3L(176306-178963)
    worm
    (Caenorhabditis elegans)
    Secernentea arrd-166
    arrd-126
    (see all 3)
    Protein ARRD-12 (arrd-12) mRNA, complete cds
    (see all 3)
    24(a)
    23(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(12484732-12488343) WBGene00013043
    II(13766318-13768403) WBGene00011053


    ENSEMBL Gene Tree for ARRDC3 (if available)
    TreeFam Gene Tree for ARRDC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARRDC3 gene
    TXNIP2  ARRDC12  ARRDC22  ARRDC42  
    3 SIMAP similar genes for ARRDC3 using alignment to 1 protein entry:     ARRD3_HUMAN:
    ARRDC4    ARRDC2    TXNIP

    Find genes that share paralogs with ARRDC3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARRDC3 (see all 183)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1135773321,2
    C--90664060(+) AAAAC-/TATGT 
            
    TATGT
    1 -- int11Minor allele frequency- TATGT:0.00CSA 2
    rs1396968171,2
    --90664077(+) ATGTAC/TTCTTG 1 -- int10--------
    rs1810753331,2
    --90664146(+) ATTTTA/GCCTGG 1 -- int10--------
    rs100690321,2
    C,F--90664320(+) AAATTA/CGGTGG 1 -- int16Minor allele frequency- C:0.23NA WA EA 364
    rs68690481,2
    C,F,A--90664322(+) ATTAGG/CTGGGT 1 -- int16Minor allele frequency- C:0.46NA WA CSA EA 363
    rs1151056821,2
    C,F--90664360(+) TACTTC/TGGAGG 1 -- int11Minor allele frequency- T:0.04WA 118
    rs1429303311,2
    --90664399(+) GAGTTC/GGTCAG 1 -- int10--------
    rs1156464321,2
    C,F--90664441(+) TCTTAC/TCCAGA 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1855073231,2
    --90664629(+) TTTTCC/TTAAAA 1 -- ut310--------
    rs2013027871,2
    C--90664684(+) AAAGAA/GAAATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARRDC3 (90664541 - 90679176 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARRDC3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARRDC3
    DNA2.0 Custom Variant and Variant Library Synthesis for ARRDC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612464    OMIM disorders: --


    Find genes that share disorders with ARRDC3           About GenesLikeMe

    Genetic Association Database (GAD): ARRDC3
    Human Genome Epidemiology (HuGE) Navigator: ARRDC3 (2 documents)

    Export disorders for ARRDC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARRDC3 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ARRDC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins. (PubMed id 19605364)1, 3 Patwari P....Lee R.T. (J. Biol. Chem. 2009)
    3. Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling. (PubMed id 16269462)1, 2 Oka S....Yodoi J. (Endocrinology 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Distinct roles for I^-arrestin2 and arrestin-domain-containing proteins in I^2 adrenergic receptor trafficking. (PubMed id 23208550)1 Han S.O....Shenoy S.K. (EMBO Rep. 2013)
    6. Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. (PubMed id 23319801)1 Rafiq S....Eccles D. (Cancer Res. 2013)
    7. Mammalian I+ arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with I^ arrestins. (PubMed id 23236378)1 Shea F.F....Alvarez C.E. (PLoS ONE 2012)
    8. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    9. Genetic polymorphisms in androgen receptor-binding sites predict survival in prostate cancer patients receiving androgen-deprivation therapy. (PubMed id 21652578)1 Huang C.N....Bao B.Y. (Ann. Oncol. 2012)
    10. Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding. (PubMed id 21191027)1 Rauch S. and Martin-Serrano J. (J. Virol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57561 HGNC: 29263 AceView: ARRDC3 Ensembl:ENSG00000113369 euGenes: HUgn57561
    ECgene: ARRDC3 H-InvDB: ARRDC3

    (According to HUGE)
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    HUGE: KIAA1376

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARRDC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARRDC3 gene:
    Search GeneIP for patents involving ARRDC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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