Aliases for ARRDC3 Gene
External Ids for ARRDC3 Gene
Previous GeneCards Identifiers for ARRDC3 Gene
GeneCards Summary for ARRDC3 Gene
ARRDC3 (Arrestin Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include beta-3 adrenergic receptor binding. An important paralog of this gene is ARRDC1.
UniProtKB/Swiss-Prot for ARRDC3 Gene
Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550).