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Aliases for ARRDC3 Gene

Aliases for ARRDC3 Gene

  • Arrestin Domain Containing 3 2 3 5
  • TBP-2-Like Inducible Membrane Protein 2 3 4
  • Alpha-Arrestin 3 2 3
  • TLIMP 3 4
  • Arrestin Domain-Containing Protein 3 3
  • KIAA1376 4

External Ids for ARRDC3 Gene

Previous GeneCards Identifiers for ARRDC3 Gene

  • GC00U913741
  • GC05M090749
  • GC05M090700
  • GC05M085876
  • GC05M090664

Summaries for ARRDC3 Gene

Entrez Gene Summary for ARRDC3 Gene

  • This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016]

GeneCards Summary for ARRDC3 Gene

ARRDC3 (Arrestin Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include beta-3 adrenergic receptor binding. An important paralog of this gene is ARRDC2.

UniProtKB/Swiss-Prot for ARRDC3 Gene

  • Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARRDC3 Gene

Genomics for ARRDC3 Gene

Regulatory Elements for ARRDC3 Gene

Enhancers for ARRDC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARRDC3 on UCSC Golden Path with GeneCards custom track

Promoters for ARRDC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ARRDC3 Gene

Chromosome:
5
Start:
91,368,724 bp from pter
End:
91,383,359 bp from pter
Size:
14,636 bases
Orientation:
Minus strand

Genomic View for ARRDC3 Gene

Genes around ARRDC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARRDC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARRDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARRDC3 Gene

Proteins for ARRDC3 Gene

  • Protein details for ARRDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B67-ARRD3_HUMAN
    Recommended name:
    Arrestin domain-containing protein 3
    Protein Accession:
    Q96B67
    Secondary Accessions:
    • A8K6T8
    • Q9P2H1

    Protein attributes for ARRDC3 Gene

    Size:
    414 amino acids
    Molecular mass:
    46395 Da
    Quaternary structure:
    • Interacts (via PPXY motifs) with NEDD4 (via WW domains) (PubMed:20559325, PubMed:23208550, PubMed:24379409). Interacts with ADRB2 (PubMed:20559325, PubMed:21982743, PubMed:25220262). Interacts with ADRB3 (PubMed:21982743). Interacts with HGS (via PPXY motifs) (PubMed:23208550). Does not bind TXN (thioredoxin) (PubMed:16269462).
    SequenceCaution:
    • Sequence=BAA92614.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARRDC3 Gene

neXtProt entry for ARRDC3 Gene

Post-translational modifications for ARRDC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARRDC3 Gene

No data available for DME Specific Peptides for ARRDC3 Gene

Domains & Families for ARRDC3 Gene

Gene Families for ARRDC3 Gene

Protein Domains for ARRDC3 Gene

Suggested Antigen Peptide Sequences for ARRDC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B67

UniProtKB/Swiss-Prot:

ARRD3_HUMAN :
  • Belongs to the arrestin family.
Family:
  • Belongs to the arrestin family.
genes like me logo Genes that share domains with ARRDC3: view

Function for ARRDC3 Gene

Molecular function for ARRDC3 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550).
UniProtKB/Swiss-Prot Induction:
By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041 (a PPARD ligand), by vitamin D3 and, to a lesser extent, by phorbol myristate acetate (PMA) in the promyelocytic leukemia HL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist) (PubMed:16269462). Up-regulated by fasting (PubMed:21982743).

Gene Ontology (GO) - Molecular Function for ARRDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20603614
GO:0031699 beta-3 adrenergic receptor binding IDA 21982743
genes like me logo Genes that share ontologies with ARRDC3: view
genes like me logo Genes that share phenotypes with ARRDC3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARRDC3 Gene

Localization for ARRDC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARRDC3 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome. Endosome. Early endosome. Note=Associated with plasma membrane, as well as with endosomes and lysosomes during endocytosis (PubMed:16269462, PubMed:23208550, PubMed:20559325). {ECO:0000269 PubMed:16269462, ECO:0000269 PubMed:20559325, ECO:0000269 PubMed:23208550}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARRDC3 Gene COMPARTMENTS Subcellular localization image for ARRDC3 gene
Compartment Confidence
endosome 5
plasma membrane 5
lysosome 4
vacuole 4
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARRDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005768 endosome IDA 23236378
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane IDA 23236378
genes like me logo Genes that share ontologies with ARRDC3: view

Pathways & Interactions for ARRDC3 Gene

SuperPathways for ARRDC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARRDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0031651 negative regulation of heat generation IEA --
GO:0043588 skin development IEA --
GO:0044252 negative regulation of multicellular organismal metabolic process IEA --
GO:0051443 positive regulation of ubiquitin-protein transferase activity IPI 23236378
genes like me logo Genes that share ontologies with ARRDC3: view

No data available for Pathways by source and SIGNOR curated interactions for ARRDC3 Gene

Drugs & Compounds for ARRDC3 Gene

No Compound Related Data Available

Transcripts for ARRDC3 Gene

Unigene Clusters for ARRDC3 Gene

Arrestin domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: -
SP5: - - - -
SP6: - - - -
SP7:

Relevant External Links for ARRDC3 Gene

GeneLoc Exon Structure for
ARRDC3
ECgene alternative splicing isoforms for
ARRDC3

Expression for ARRDC3 Gene

mRNA expression in normal human tissues for ARRDC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARRDC3 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARRDC3 Gene



Protein tissue co-expression partners for ARRDC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARRDC3 Gene:

ARRDC3

SOURCE GeneReport for Unigene cluster for ARRDC3 Gene:

Hs.24684

mRNA Expression by UniProt/SwissProt for ARRDC3 Gene:

Q96B67-ARRD3_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow (PubMed:16269462). Strong expression in differentiated adipocytes compared to preadipocytes (PubMed:16269462). Detected in omental fat and subcutaneous fat tissue (PubMed:21982743).
genes like me logo Genes that share expression patterns with ARRDC3: view

Primer Products

No data available for mRNA differential expression in normal tissues for ARRDC3 Gene

Orthologs for ARRDC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARRDC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARRDC3 34
  • 96.62 (n)
  • 98.79 (a)
ARRDC3 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARRDC3 34
  • 96.78 (n)
  • 99.03 (a)
ARRDC3 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arrdc3 34
  • 92.67 (n)
  • 98.07 (a)
Arrdc3 16
Arrdc3 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARRDC3 34
  • 99.92 (n)
  • 99.76 (a)
ARRDC3 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arrdc3 34
  • 93.56 (n)
  • 98.07 (a)
oppossum
(Monodelphis domestica)
Mammalia ARRDC3 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARRDC3 35
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARRDC3 34
  • 87.12 (n)
  • 96.38 (a)
ARRDC3 35
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARRDC3 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arrdc3 34
  • 83.58 (n)
  • 92.48 (a)
Str.3902 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.17848 34
zebrafish
(Danio rerio)
Actinopterygii arrdc3a 34
  • 77.4 (n)
  • 87.07 (a)
wufc21e01 34
arrdc3a 35
  • 86 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5882 34
fruit fly
(Drosophila melanogaster)
Insecta Vdup1 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arrd-12 35
  • 23 (a)
ManyToMany
arrd-16 35
  • 24 (a)
ManyToMany
arrd-6 35
  • 21 (a)
ManyToMany
Species where no ortholog for ARRDC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARRDC3 Gene

ENSEMBL:
Gene Tree for ARRDC3 (if available)
TreeFam:
Gene Tree for ARRDC3 (if available)

Paralogs for ARRDC3 Gene

Paralogs for ARRDC3 Gene

(3) SIMAP similar genes for ARRDC3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARRDC3: view

Variants for ARRDC3 Gene

Sequence variations from dbSNP and Humsavar for ARRDC3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs12188429 -- 91,378,020(+) TTTTT(A/T)AAAAA intron-variant
rs2303130 -- 91,373,954(-) AGTTT(C/T)GATCA intron-variant
rs17638113 -- 91,369,208(+) GACAA(A/G)TATTC nc-transcript-variant, utr-variant-3-prime
rs17638138 -- 91,369,656(+) TGGGG(C/T)TAAAT nc-transcript-variant, utr-variant-3-prime
rs10067708 -- 91,376,509(+) AATTT(A/T)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARRDC3 Gene

Variant ID Type Subtype PubMed ID
nsv1145067 CNV deletion 24896259
nsv475213 CNV novel sequence insertion 20440878

Variation tolerance for ARRDC3 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARRDC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARRDC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARRDC3 Gene

Disorders for ARRDC3 Gene

Relevant External Links for ARRDC3

Genetic Association Database (GAD)
ARRDC3
Human Genome Epidemiology (HuGE) Navigator
ARRDC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARRDC3

No disorders were found for ARRDC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARRDC3 Gene

Publications for ARRDC3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 65
  2. Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). (PMID: 24379409) Qi S. … Hurley J.H. (J. Biol. Chem. 2014) 3 4 65
  3. Insights into I^2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. (PMID: 25220262) Qi S. … Hurley J.H. (Protein Sci. 2014) 3 4 65
  4. Distinct roles for I^-arrestin2 and arrestin-domain-containing proteins in I^2 adrenergic receptor trafficking. (PMID: 23208550) Han S.O. … Shenoy S.K. (EMBO Rep. 2013) 3 4 65
  5. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. (PMID: 21982743) Patwari P. … Lee R.T. (Cell Metab. 2011) 3 4 65

Products for ARRDC3 Gene

Sources for ARRDC3 Gene

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