ARRDC3 Gene
protein-coding GIFtS: 46
GCID: GC05M090700
|
|
arrestin domain containing 3
| |
Aliases for ARRDC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Arrestin Domain Containing 31 2 | | KIAA13761 3 5 | | TLIMP2 3 5 | | TBP-2-Like Inducible Membrane Protein2 3 | | Arrestin Domain-Containing Protein 32 | | Thioredoxin-Binding Protein-2-Like Inducible Membrane2 |
Export aliases for ARRDC3 gene to outside databasesPrevious GC identifers: GC00U913741 GC05M090749 GC05M085876 |
Summaries for ARRDC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for ARRDC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARRDC3 gene promoter: ATF-2 Nkx2-5 Meis-1b Gfi-1 Egr-2 POU2F1 POU2F1a c-Jun Meis-1a Meis-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for ARRDC3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARRDC3 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q14.3 Ensembl cytogenetic band: 5q14.3 HGNC cytogenetic band: 5q14.3ARRDC3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M090700: view genomic region
(about GC identifiers)
Start:
|
90,664,541 bp from pter |
End:
|
90,679,176 bp from pter |
Size:
|
14,636 bases |
Orientation:
|
minus strand |
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Proteins for ARRDC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ARRD3_HUMAN, Q96B67 (See
protein sequence)Recommended Name: Arrestin domain-containing protein 3 Size: 414 amino acids; 46395 Da
Subunit: Does not bind TXN (thioredoxin)
Subcellular location: Cytoplasm. Note=Associated with plasma membrane, as well as with endodomes and lysosomes duringendocytosis
Sequence caution: Sequence=BAA92614.1; Type=Erroneous initiation;
Secondary accessions: A8K6T8 Q9P2H1Explore the universe of human proteins at neXtProt for ARRDC3: NX_Q96B67
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96B67 ARRDC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065852.1 ENSEMBL proteins: ENSP00000265138 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
ARRDC3 for ontologies About GeneDecksing
ARRDC3 Antibody Products: Assay Products for ARRDC3: |
Protein
Domains / Families for ARRDC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARRDC3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96B67ProtoNet protein and cluster: Q96B67 UniProtKB/Swiss-Prot: ARRD3_HUMAN, Q96B67Similarity: Belongs to the arrestin family |
Function for ARRDC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ARRD3_HUMAN, Q96B67Induction: By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041 (aPPARD ligand), by vitamin D3 and, to a lesser extent, by phorbol myristate acetate (PMA) in the promyelocytic leukemiaHL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARRDC3 (NM_020801) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARRDC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC3  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0031699 | beta-3 adrenergic receptor binding |
IDA | -- |
ARRDC3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ARRDC3: Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Arrdc3):
ARRDC3 for phenotypes About GeneDecksing
|
Pathways & Interactions for ARRDC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARRDC3
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
 5/7 Interacting proteins for ARRDC3 (Q96B671, 3 ENSP000002651384) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001659 | temperature homeostasis |
IEA | -- | | GO:0007165 | signal transduction |
-- | -- | | GO:0031651 | negative regulation of heat generation |
IEA | -- | | GO:0044252 | negative regulation of multicellular organismal metabolic process |
IEA | -- | | GO:0060613 | fat pad development |
IEA | -- |
ARRDC3 for ontologies About GeneDecksing
|
Drugs & Compounds for ARRDC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ARRDC3 Search CenterWatch for drugs/clinical trials and news about ARRDC3 / ARRD3 
|
Transcripts for ARRDC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ARRDC3 gene: NM_020801.2 Unigene Cluster for ARRDC3: Arrestin domain containing 3 Hs.24684 [show with all ESTs]Unigene Representative Sequence: NM_0208017 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000265138(uc003kjz.2) ENST00000511391 ENST00000505631 ENST00000514284 ENST00000508948 ENST00000503192 ENST00000507075
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARRDC3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARRDC3 (NM_020801) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARRDC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC3  |
Additional cDNA sequence: AB037797.1 AK025028.1 AK026917.1 AK291753.1 BC015928.2 BC053619.1 12 DOTS entries: DT.444441 DT.101982388 DT.91664773 DT.92045430 DT.99962199 DT.100799420 DT.429724 DT.100796664 DT.100796665 DT.91712127 DT.95356564 DT.40210289 24/202 AceView cDNA sequences (see all 202): BQ230954 AI561022 AA604775 BM467761 AV702495 AL543552 AA872631 BM893862 BU507427 CR624187 AB037797 CK823448 AI049901 AA862532 AA862534 CR608314 AW157029 AA411082 CA415872 BM675230 AW613677 AI140725 AW572645 AA505270 GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ARRDC3 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | |
| SP1: | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ARRDC3
|
Expression for ARRDC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARRDC3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See ARRDC3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARRDC3
SOURCE GeneReport for Unigene cluster: Hs.24684 UniProtKB/Swiss-Prot: ARRD3_HUMAN, Q96B67Tissue specificity: Highly expressed in skeletal muscle, placenta, kidney, adrenal gland, lymph node, mammary gland,thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strongexpression in differentiated adipocytes compared to preadipocytes SABiosciences Custom PCR Arrays for ARRDC3
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARRDC3 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARRDC3 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARRDC3 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARRDC3 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC3 |
Orthologs for ARRDC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARRDC3 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for ARRDC3 (if available) TreeFam Gene Tree for ARRDC3 (if available)  |
Paralogs for ARRDC3 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ARRDC3 gene
- TXNIP2 ARRDC12 ARRDC22 ARRDC42
3 SIMAP similar genes for ARRDC3 using alignment to 1 protein entry: ARRD3_HUMAN:ARRDC4 ARRDC2 TXNIP
ARRDC3 for paralogs About GeneDecksing
|
Genomic Variants for ARRDC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 5 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ARRDC3 (90664541 - 90679176 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ARRDC3: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARRDC3 |
|
Disorders
/ Diseases for ARRDC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARRDC3 for disorders About GeneDecksing
OMIM gene information: 612464
OMIM disorders: --
3 diseases for ARRDC3: About MalaCardsbreast cancer thyroiditis leukemia Human Genome Epidemiology (HuGE) Navigator: ARRDC3 (2 documents) Export disorders for ARRDC3 gene to outside databases
|
Publications for ARRDC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARRDC3 gene, integrated from 9 sources (see all 15): (articles sorted by number of sources associating them with ARRDC3) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling. (PubMed id 16269462)1, 2 Oka S....Yodoi J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Genetic polymorphisms in androgen receptor-binding sit es predict survival in prostate cancer patients receiving androgen-deprivation t herapy. (PubMed id 21652578)1 Huang C.N....Bao B.Y. (2012)
- Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding. (PubMed id 21191027)1 Rauch S. and Martin-Serrano J. (2011)
- The arrestin domain-containing 3 protein regulates bod y mass and energy expenditure. (PubMed id 21982743)1 Patwari P....Lee R.T. (2011)
- ARRDC3 suppresses breast cancer progression by negati vely regulating integrin beta4. (PubMed id 20603614)1 Draheim K.M....Lyle S. (2010)
- A Three-Stage Genome-Wide Association Study of Genera l Cognitive Ability: Hunting the Small Effects. (PubMed id 20306291)1 Davis O.S....Plomin R. (2010)
- Arrestin domain-containing protein 3 recruits the NED D4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor. (PubMed id 20559325)1 Nabhan J.F....Lu Q. (2010)
|
External Searches for ARRDC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ARRDC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARRDC3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ARRDC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ARRDC3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARRDC3 gene: Search GeneIP for patents involving ARRDC3
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ARRDC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | ARRDC3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARRDC3 |
|  |  |  | | | Search ThermoFisher Antibodies for ARRDC3 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARRDC3 |
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